CHEMBL2312639


SMILES O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1
InChIKey AROYESYOAIFFDX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 492.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.25 7.25 7.25 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.34 6.34 6.34 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.46 7.46 7.46 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.47 7.47 7.47 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.77 7.77 7.77 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 5.25 5.25 5.25 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 4.81 4.81 4.81 ChEMBL