JNJ-10191584
| SMILES | CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl |
| InChIKey | MOIWSUQWIOVGRH-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 1 |
| Molecular weight (Da) | 278.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H4 | HRH4 | Human | Histamine | A | pKi | 7.1 | 7.44 | 7.7 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKd | 7.7 | 7.7 | 7.7 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKi | 4.7 | 4.98 | 5.4 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKi | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H4 | HRH4 | Human | Histamine | A | pIC50 | 6.28 | 6.57 | 6.86 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pEC50 | 5.5 | 5.5 | 5.5 | ChEMBL |