CHEMBL2376803


SMILES CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1
InChIKey HTLDHQKBLGJBRF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 298.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKi 7.71 7.71 7.71 ChEMBL
H4 HRH4 Rat Histamine A pKi 7.56 7.56 7.56 ChEMBL
H4 HRH4 Human Histamine A pKd 7.99 7.99 7.99 ChEMBL
H4 HRH4 Human Histamine A pKi 8.19 8.19 8.19 ChEMBL
H2 HRH2 Human Histamine A pKi 5.55 5.55 5.55 ChEMBL
H1 HRH1 Human Histamine A pKi 4.78 4.78 4.78 ChEMBL
H3 HRH3 Human Histamine A pKi 6.82 6.82 6.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 7.01 7.01 7.01 ChEMBL