L-tryptophan


SMILES OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N
InChIKey QIVBCDIJIAJPQS-VIFPVBQESA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 3
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 7DTU 7M3E 7DTV 7DD6 7DD5 7M3F 7DD7 7M3G

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR139 GP139 Human A orphans A pKi 3.13 3.13 3.13 Guide to Pharmacology
CaS CASR Human Calcium-sensing C pKd 2.6 3.5 4.4 Guide to Pharmacology
CaS CASR Human Calcium-sensing C pKd 8.36 8.36 8.36 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR139 GP139 Human A orphans A pEC50 3.66 3.66 3.66 Guide to Pharmacology
GPR139 GP139 Human A orphans A pIC50 4.59 4.59 4.59 Guide to Pharmacology
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL
GPR139 GP139 Human A orphans A pIC50 8.34 8.34 8.34 Drug Central