CHEMBL224820


SMILES COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
InChIKey HNLISXDOJMLKAY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 435.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKd 8.02 8.02 8.02 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.58 7.58 7.58 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.58 7.58 7.58 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pEC50 5.2 5.2 5.2 ChEMBL