mesoridazine


SMILES CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C
InChIKey SLVMESMUVMCQIY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 386.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.98 6.98 6.98 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.26 7.26 7.26 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.39 6.39 6.39 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 6.99 6.99 6.99 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.66 8.66 8.66 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.64 7.64 7.64 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.93 8.15 8.32 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.14 7.14 7.14 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.42 6.42 6.42 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 7.87 7.87 7.87 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.1 8.2 8.3 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.8 7.0 7.1 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.72 7.94 8.37 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.74 8.74 8.74 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.05 7.05 7.05 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.17 7.5 7.82 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.72 7.72 7.72 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.22 7.22 7.22 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.59 8.59 8.59 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.04 8.04 8.04 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.14 7.14 7.14 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.8 7.9 8.0 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 7.05 7.05 7.05 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.11 8.11 8.11 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.11 8.11 8.11 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
D1 DRD1 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D4 DRD4 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
H1 HRH1 Human Histamine A pKi 8.06 8.06 8.06 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Human Dopamine A pKi 8.11 8.11 8.11 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database