ArrestinDb

BETAHISTINE

Agent/drug
Bioactivity

BETAHISTINE

SMILES	CNCCc1ccccn1
InChIKey	UUQMNUMQCIQDMZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	136.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Rat	Histamine	A	pKi	5.69	5.69	5.69	ChEMBL
H₃	HRH3	Rat	Histamine	A	pKi	8.24	8.24	8.24	Drug Central

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Human	Histamine	A	pEC50	8.02	8.02	8.02	Drug Central
TA₁	TAAR1	Human	Trace amine	A	pIC50	5.22	5.22	5.22	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.91	5.91	5.91	ChEMBL

Showing 1 to 3 of 3 entries

BETAHISTINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 2

Phase II 4

Phase III 0

Approved Yes

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z		0.037	1	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Excessive weight gain	MG43.6		0.037	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Meniere disease	AB31.0		0.439	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3		0.084	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Vertigo, unspecified	MB48.0Z		0.577	4	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z		0.114	1	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Excessive weight gain	MG43.6		0.037	2	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Meniere disease	AB31.0		0.438	4	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3		0.074	2	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Vertigo, unspecified	MB48.0Z		0.370	4	Yes

Showing 1 to 10 of 10 entries