clozapine
| SMILES | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 |
| InChIKey | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 0 |
| Molecular weight (Da) | 326.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.8 | 6.85 | 6.9 | Guide to Pharmacology |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| 5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.6 | 8.3 | 9.0 | Guide to Pharmacology |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.0 | 8.4 | 8.8 | Guide to Pharmacology |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.25 | 6.5 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.8 | 7.95 | 8.1 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.5 | 7.8 | Guide to Pharmacology |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
| D1 | DRD1 | Human | Dopamine | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.8 | 6.35 | 6.9 | Guide to Pharmacology |
| D3 | DRD3 | Human | Dopamine | A | pKi | 5.2 | 5.75 | 6.3 | Guide to Pharmacology |
| D4 | DRD4 | Human | Dopamine | A | pKi | 7.5 | 7.5 | 7.5 | Guide to Pharmacology |
| D5 | DRD5 | Human | Dopamine | A | pKi | 6.6 | 6.6 | 6.6 | Guide to Pharmacology |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.2 | 6.45 | 6.7 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 7.5 | 7.95 | 8.4 | Guide to Pharmacology |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 5.7 | 5.7 | 5.7 | Guide to Pharmacology |
| H4 | HRH4 | Mouse | Histamine | A | pKi | 5.5 | 5.5 | 5.5 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| H3 | HRH3 | Rat | Histamine | A | pKi | 5.8 | 5.8 | 5.8 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.7 | 8.2 | Guide to Pharmacology |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| 5-HT5A | 5HT5A | Mouse | 5-Hydroxytryptamine | A | pKi | 5.3 | 5.3 | 5.3 | Guide to Pharmacology |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 7.0 | 7.36 | 7.72 | ChEMBL |
| H1 | HRH1 | Rat | Histamine | A | pKi | 7.85 | 8.23 | 8.54 | ChEMBL |
| D4 | DRD4 | Rat | Dopamine | A | pKi | 7.5 | 7.7 | 8.05 | ChEMBL |
| D1 | DRD1 | Pig | Dopamine | A | pKi | 6.38 | 6.38 | 6.38 | ChEMBL |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 6.38 | 6.38 | 6.38 | ChEMBL |
| β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 4.58 | 4.58 | 4.58 | ChEMBL |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 6.16 | 6.16 | 6.16 | ChEMBL |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.77 | 8.2 | ChEMBL |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 6.3 | 6.56 | 6.79 | ChEMBL |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.38 | 7.75 | 8.1 | ChEMBL |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| D5 | DRD5 | Human | Dopamine | A | pKi | 6.0 | 6.36 | 6.7 | ChEMBL |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 6.27 | 6.65 | 7.37 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 7.91 | 8.14 | 8.42 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 6.02 | 6.02 | 6.02 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 7.54 | 7.88 | 8.45 | ChEMBL |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.0 | 8.0 | 8.0 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.0 | 7.48 | 7.96 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.66 | 7.74 | 7.82 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.26 | 7.74 | 8.68 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.0 | 8.16 | 8.94 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.72 | 7.81 | 8.0 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKd | 7.43 | 7.43 | 7.43 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.3 | 6.58 | 6.75 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKd | 7.15 | 7.65 | 7.92 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 5.45 | 5.45 | 5.45 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.77 | 7.77 | 7.77 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.0 | 7.51 | 8.02 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.64 | 8.26 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.0 | 6.96 | 7.62 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.0 | 7.7 | 8.2 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.77 | 8.64 | 9.24 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKd | 8.51 | 8.51 | 8.51 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.0 | 7.38 | 7.77 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.32 | 8.5 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.77 | 6.88 | 7.0 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 6.0 | 7.04 | 8.12 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pKi | 5.05 | 7.58 | 8.05 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 6.1 | 6.89 | 7.47 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKi | 6.2 | 6.2 | 6.2 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.19 | 6.79 | 7.42 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.0 | 8.38 | 9.01 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 8.1 | 8.4 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.91 | 8.54 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.87 | 8.2 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 6.64 | 8.06 | 8.92 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 6.0 | 6.41 | 7.06 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 6.0 | 7.0 | 8.15 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.09 | 8.18 | 9.26 | PDSP Ki database |
| 5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pKi | 7.79 | 7.79 | 7.79 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 7.51 | 8.02 | 8.4 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.21 | 7.68 | 8.2 | PDSP Ki database |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 6.06 | 6.61 | 7.28 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.83 | 6.84 | 8.06 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.16 | 7.88 | 8.88 | PDSP Ki database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 6.27 | 6.67 | 7.05 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 6.37 | 6.89 | 7.55 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 6.02 | 6.61 | 7.57 | PDSP Ki database |
| D4 | DRD4 | Human | Dopamine | A | pKi | 7.26 | 7.77 | 8.8 | PDSP Ki database |
| D5 | DRD5 | Human | Dopamine | A | pKi | 6.55 | 6.62 | 6.7 | PDSP Ki database |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.77 | 8.0 | 8.4 | PDSP Ki database |
| D4 | DRD4 | Rat | Dopamine | A | pKi | 7.49 | 7.68 | 8.02 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.41 | 7.89 | 8.3 | PDSP Ki database |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.99 | 8.2 | 8.46 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.47 | 7.89 | 8.54 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.85 | 7.17 | 7.62 | PDSP Ki database |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 7.08 | 7.62 | 8.16 | PDSP Ki database |
| 5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 6.83 | 7.08 | 7.32 | PDSP Ki database |
| 5-HT6 | 5HT6R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.4 | 7.7 | 8.19 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 7.28 | 7.75 | PDSP Ki database |
| D2 | A0A287B0Q7 | Pig | Dopamine | A | pKi | 5.92 | 6.58 | 7.01 | PDSP Ki database |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 6.19 | 6.55 | 7.08 | PDSP Ki database |
| H3 | HRH3 | Rat | Histamine | A | pKi | 5.52 | 5.64 | 5.76 | PDSP Ki database |
| H3 | HRH3 | Human | Histamine | A | pKi | 5.0 | 5.25 | 6.0 | PDSP Ki database |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.4 | 7.59 | 7.68 | PDSP Ki database |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.48 | 5.72 | 5.92 | PDSP Ki database |
| 5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 7.89 | 8.16 | 8.54 | PDSP Ki database |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 5.68 | 6.17 | 6.41 | PDSP Ki database |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 5.67 | 6.28 | 6.89 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 7.64 | 8.46 | 8.91 | PDSP Ki database |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.57 | 7.6 | 7.66 | PDSP Ki database |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 5.0 | 5.15 | 5.3 | PDSP Ki database |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 5.0 | 5.39 | 5.78 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 6.7 | 8.73 | 9.64 | PDSP Ki database |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.77 | 6.42 | 6.82 | PDSP Ki database |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.07 | 6.34 | 6.7 | PDSP Ki database |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.55 | 5.67 | 5.72 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 7.39 | 7.79 | 8.54 | PDSP Ki database |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.96 | 7.59 | 8.15 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.51 | 8.36 | 8.85 | PDSP Ki database |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.69 | 7.16 | 7.85 | PDSP Ki database |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.03 | 7.79 | 8.3 | PDSP Ki database |
| α1B | A0A4X1U0M4 | Pig | Adrenoceptors | A | pKi | 7.4 | 7.4 | 7.4 | PDSP Ki database |
| α1A | Q9TSW7 | Pig | Adrenoceptors | A | pKi | 6.2 | 7.63 | 8.5 | PDSP Ki database |
| β2 | ADRB2 | Rat | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 6.92 | 7.06 | 7.19 | PDSP Ki database |
| AT1 | AGTR1 | Human | Angiotensin | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT4 | 5HT4R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | PDSP Ki database |
| A1 | AA1R | Rat | Adenosine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.51 | 8.51 | 8.51 | PDSP Ki database |
| 5-HT1D | F1MMU1 | Bovine | 5-Hydroxytryptamine | A | pKi | 5.8 | 5.99 | 6.15 | PDSP Ki database |
| D3 | F1N454 | Bovine | Dopamine | A | pKi | 6.06 | 6.23 | 6.4 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.59 | 6.86 | 6.98 | PDSP Ki database |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.8 | 6.37 | PDSP Ki database |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 5.41 | 5.71 | 6.0 | PDSP Ki database |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.54 | 7.85 | 8.22 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.72 | 8.58 | 8.8 | PDSP Ki database |
| EP3 | PE2R3 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| EP4 | PE2R4 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| CB1 | CNR1 | Rat | Cannabinoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| H3 | HRH3 | Guinea pig | Histamine | A | pKi | 5.2 | 5.2 | 5.2 | PDSP Ki database |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.26 | 8.0 | 8.72 | PDSP Ki database |
| M4 | ACM4 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.74 | 7.74 | 7.74 | PDSP Ki database |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.0 | 8.0 | 8.0 | PDSP Ki database |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.59 | 7.76 | 7.85 | PDSP Ki database |
| D1 | DRD1 | Mouse | Dopamine | A | pKi | 7.26 | 7.26 | 7.26 | PDSP Ki database |
| μ | OPRM | Rat | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| CCK2 | GASR | Rat | Cholecystokinin | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| PAF | PTAFR | Human | Platelet-activating factor | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| TP | TA2R | Human | Prostanoid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| δ | OPRD | Mouse | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| κ | OPRK | Guinea pig | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.15 | 8.15 | 8.15 | PDSP Ki database |
| D1 | DRD1 | Pig | Dopamine | A | pKi | 6.58 | 6.58 | 6.58 | PDSP Ki database |
| D1 | DRD1 | Rhesus macaque | Dopamine | A | pKi | 6.39 | 6.39 | 6.39 | PDSP Ki database |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| D5 | DRD5 | Human | Dopamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| H2 | HRH2 | Human | Histamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| H4 | HRH4 | Human | Histamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| H4 | HRH4 | Mouse | Histamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 8.2 | 8.2 | 8.2 | Drug Central |
| D1 | DRD1 | Pig | Dopamine | A | pKi | 8.2 | 8.2 | 8.2 | Drug Central |
| H4 | HRH4 | Rat | Histamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| H3 | HRH3 | Rat | Histamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| D2 | DRD2 | Green monkey | Dopamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| D3 | DRD3 | Green monkey | Dopamine | A | pKi | 8.2 | 8.2 | 8.2 | Drug Central |
| D4 | DRD4 | Rat | Dopamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT5A | 5HT5A | Mouse | 5-Hydroxytryptamine | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 6.89 | 6.89 | 6.89 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.4 | 8.05 | 8.7 | Guide to Pharmacology |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.8 | 9.2 | 9.6 | Guide to Pharmacology |
| H2 | HRH2 | Human | Histamine | A | pKi | 6.82 | 6.82 | 6.82 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.34 | 7.34 | 7.34 | ChEMBL |
| D2 | DRD2 | Mouse | Dopamine | A | pKi | 7.05 | 7.05 | 7.05 | PDSP Ki database |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| H4 | HRH4 | Rat | Histamine | A | pKi | 5.7 | 5.7 | 5.7 | Guide to Pharmacology |
| H1 | HRH1 | Rat | Histamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| D2 | DRD2 | Green monkey | Dopamine | A | pKi | 6.59 | 6.59 | 6.59 | ChEMBL |
| D3 | DRD3 | Green monkey | Dopamine | A | pKi | 6.33 | 6.33 | 6.33 | ChEMBL |
| 5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKd | 6.77 | 6.83 | 6.9 | ChEMBL |
| 5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKi | 7.5 | 7.5 | 7.5 | PDSP Ki database |
| β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 8.34 | 8.34 | 8.34 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.9 | 7.9 | 7.9 | Guide to Pharmacology |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
| 5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pIC50 | 8.52 | 8.52 | 8.52 | ChEMBL |
| 5-HT1A | 5HT1A | Mouse | 5-Hydroxytryptamine | A | pIC50 | 5.7 | 5.7 | 5.7 | ChEMBL |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 7.64 | 7.78 | 8.05 | ChEMBL |
| D2 | DRD2 | Bovine | Dopamine | A | pIC50 | 6.35 | 6.6 | 6.85 | ChEMBL |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pIC50 | 7.96 | 7.96 | 7.96 | ChEMBL |
| D1 | DRD1 | Rat | Dopamine | A | pIC50 | 6.72 | 6.82 | 6.89 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.6 | 5.64 | 5.68 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 8.19 | 8.19 | 8.19 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.64 | 7.64 | 7.64 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 7.42 | 7.42 | 7.42 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 7.0 | 7.25 | 7.5 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 8.1 | 8.1 | 8.1 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pIC50 | 5.44 | 5.44 | 5.44 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 7.46 | 7.46 | 7.46 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.89 | 7.89 | 7.89 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 7.05 | 7.05 | 7.05 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.35 | 7.35 | 7.35 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 8.31 | 8.31 | 8.31 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pEC50 | 9.4 | 9.4 | 9.4 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.11 | 7.11 | 7.11 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 7.96 | 7.96 | 7.96 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pEC50 | 7.7 | 7.7 | 7.7 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.32 | 6.32 | 6.32 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.97 | 6.97 | 6.97 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pIC50 | 6.78 | 7.21 | 7.77 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 5.56 | 6.35 | 7.42 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.7 | 6.05 | 6.57 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.0 | 8.02 | 8.03 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 7.69 | 7.78 | 7.96 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 8.0 | 8.11 | 8.22 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pEC50 | 6.6 | 6.6 | 6.6 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pIC50 | 6.82 | 6.82 | 6.82 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 7.92 | 8.15 | 8.38 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 6.35 | 6.47 | 6.59 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 6.41 | 6.86 | 8.05 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.09 | 8.09 | 8.09 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pEC50 | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.25 | 8.25 | 8.25 | Drug Central |
| D2 | DRD2 | Mouse | Dopamine | A | pIC50 | 8.18 | 8.18 | 8.18 | Drug Central |
| 5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pIC50 | 8.07 | 8.07 | 8.07 | Drug Central |
| 5-HT1A | 5HT1A | Mouse | 5-Hydroxytryptamine | A | pIC50 | 8.24 | 8.24 | 8.24 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pIC50 | 8.17 | 8.17 | 8.17 | Drug Central |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.5 | 4.5 | 4.5 | ChEMBL |
| A3 | AA3R | Human | Adenosine | A | pIC50 | 8.17 | 8.17 | 8.17 | Drug Central |
| D2 | DRD2 | Mouse | Dopamine | A | pIC50 | 6.54 | 6.54 | 6.54 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pIC50 | 6.8 | 6.8 | 6.8 | ChEMBL |