ArrestinDb

clemastine

Agent/drug
Bioactivity

clemastine

SMILES	CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1
InChIKey	YNNUSGIPVFPVBX-NHCUHLMSSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	343.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.68	7.68	7.68	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.39	7.39	7.39	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.82	7.82	7.82	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.77	6.96	7.16	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.32	6.58	6.85	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.65	7.25	7.85	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.66	6.66	6.66	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.04	8.04	8.04	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.64	7.64	7.64	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.44	7.44	7.44	ChEMBL

Showing 1 to 20 of 42 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.28	7.28	7.28	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.14	8.14	8.14	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.13	7.13	7.13	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.50	7.50	7.50	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.74	6.74	6.74	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.51	6.51	6.51	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.02	7.02	7.02	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	6.45	6.45	6.45	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.50	7.50	7.50	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.44	7.44	7.44	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.00	7.00	7.00	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.11	7.11	7.11	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.81	5.81	5.81	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.87	6.87	6.87	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	8.13	8.13	8.13	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	9.38	9.38	9.38	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	6.43	6.43	6.43	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	6.55	6.90	7.25	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	7.41	7.41	7.41	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	7.70	7.70	7.70	ChEMBL

Showing 1 to 20 of 22 entries

clemastine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 3

Phase III 1

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	R06A, D04A	0.605	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A, D04A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A, D04A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A, D04A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Idiopathic angioedema	EB04	R06A, D04A	0.537	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Multiple sclerosis, unspecified	8A40.Z	R06A, D04A	0.543	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Optic neuritis, unspecified	9C40.1Z	R06A, D04A	0.074	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other specified multiple sclerosis	8A40.Y	R06A, D04A	0.272	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Relapsing-remitting multiple sclerosis	8A40.0	R06A, D04A	0.394	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A, D04A	0.606	4	Yes

Showing 1 to 10 of 10 entries