CHEMBL2365083


SMILES O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
InChIKey PKCRBWNXYKXDQR-APPZFPTMSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 0
Molecular weight (Da) 256.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.14 7.31 7.48 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.92 7.99 8.05 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.04 7.21 7.39 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 8.0 8.0 8.0 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 8.7 8.85 9.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 7.2 7.6 8.0 ChEMBL