PD123319


SMILES OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C
InChIKey YSTVFDAKLDMYCR-NDEPHWFRSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 508.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT2 AGTR2 Human Angiotensin A pKd 8.7 8.95 9.2 Guide to Pharmacology
AT1 AGTR1 Human Angiotensin A pKi 7.92 7.92 7.92 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT2 AGTR2 Human Angiotensin A pIC50 7.47 7.97 8.16 ChEMBL
AT2 AGTR2 Rat Angiotensin A pIC50 7.47 7.47 7.47 ChEMBL