Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 LogP

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 DOI
CHEMBL5093342 222343 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095971 222343 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
11329254 91991 0 None - 1 Guinea pig 5.0 pEC50 = 5 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 450 9 1 5 4.5 O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL225571 91991 0 None - 1 Guinea pig 5.0 pEC50 = 5 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 450 9 1 5 4.5 O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL5093342 222343 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095971 222343 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
5202 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
CHEMBL39 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
DB08839 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
134138168 154469 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
5202 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
CHEMBL39 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
DB08839 6927 72 None -9 27 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
135367816 171614 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367816 171614 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
134138168 154469 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
23643870 99639 0 None - 1 Guinea pig 5.9 pEC50 = 5.9 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243955 99639 0 None - 1 Guinea pig 5.9 pEC50 = 5.9 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL5081379 221525 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5081379 221525 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
135367820 171600 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367820 171600 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL5094493 222278 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5094493 222278 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
92042876 158115 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8014553
5202 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8014553
CHEMBL39 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8014553
DB08839 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8014553
92042876 158115 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
67268994 170747 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
67268994 170747 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367405 170975 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367405 170975 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
5 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm500880c
5202 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm500880c
CHEMBL39 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm500880c
DB08839 6927 72 None -9 27 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm500880c
11385992 91443 0 None - 1 Guinea pig 4.8 pEC50 = 4.8 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 439 8 1 3 5.2 O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL222477 91443 0 None - 1 Guinea pig 4.8 pEC50 = 4.8 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 439 8 1 3 5.2 O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
23643664 9129 8 None - 1 Guinea pig 5.8 pEC50 = 5.8 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
8434 9129 8 None - 1 Guinea pig 5.8 pEC50 = 5.8 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
CHEMBL243954 9129 8 None - 1 Guinea pig 5.8 pEC50 = 5.8 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
CHEMBL5094234 222352 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096019 222352 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5094234 222352 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096019 222352 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
11785183 91488 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222755 91488 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
124247485 170848 8 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL5084249 221684 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
124247485 170848 8 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL5084249 221684 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
24825775 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
24825775 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
102364516 120320 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321794 120320 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
11282296 150093 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL389718 150093 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
11224758 9132 5 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
8435 9132 5 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
CHEMBL225284 9132 5 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
5 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2021.113243
5202 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2021.113243
CHEMBL39 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2021.113243
DB08839 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2021.113243
25107520 194372 0 None - 1 Guinea pig 6.5 pEC50 = 6.5 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1021/jm800615e
CHEMBL494709 194372 0 None - 1 Guinea pig 6.5 pEC50 = 6.5 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1021/jm800615e
42625440 177592 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm8014553
CHEMBL445334 177592 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm8014553
92042877 155954 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3943658 155954 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
92042877 155954 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3943658 155954 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
5 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
5202 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
CHEMBL39 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
DB08839 6927 72 None -9 27 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
135367857 171383 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367857 171383 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
92042876 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
92042876 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
5202 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
CHEMBL39 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
DB08839 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
134138168 154469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
5202 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
CHEMBL39 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
DB08839 6927 72 None -9 27 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.8b00642
134138168 154469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
25107648 194002 0 None - 1 Guinea pig 6.3 pEC50 = 6.3 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 10.1021/jm800615e
CHEMBL492480 194002 0 None - 1 Guinea pig 6.3 pEC50 = 6.3 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 10.1021/jm800615e
1809 6922 32 None -194 8 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112709
4 6922 32 None -194 8 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112709
CHEMBL18840 6922 32 None -194 8 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112709
5 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
5202 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
CHEMBL39 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
DB08839 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
5 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
5202 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
CHEMBL39 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
DB08839 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
92042876 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3961059 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
92042876 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3961059 158115 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL5074190 221093 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5074190 221093 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5083607 221652 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
135453290 140384 33 None -2818 7 Human 5.3 pEC50 = 5.3 Functional
Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
CHEMBL371300 140384 33 None -2818 7 Human 5.3 pEC50 = 5.3 Functional
Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
CHEMBL5083607 221652 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
118709756 120324 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321798 120324 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
25107716 9130 43 None - 1 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
8436 9130 43 None - 1 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
CHEMBL522691 9130 43 None - 1 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
1809 6922 32 None -194 8 Human 6.2 pEC50 = 6.2 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
4 6922 32 None -194 8 Human 6.2 pEC50 = 6.2 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
CHEMBL18840 6922 32 None -194 8 Human 6.2 pEC50 = 6.2 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
1809 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
4 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
CHEMBL18840 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
1809 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
4 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
CHEMBL18840 6922 32 None -2137 8 Guinea pig 6.2 pEC50 = 6.2 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
11432177 91897 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL224820 91897 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL5083607 221652 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5083607 221652 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2018.04.059
5202 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2018.04.059
CHEMBL39 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2018.04.059
DB08839 6927 72 None -9 27 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2018.04.059
5 6927 72 None -9 27 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2020.115578
5202 6927 72 None -9 27 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2020.115578
CHEMBL39 6927 72 None -9 27 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2020.115578
DB08839 6927 72 None -9 27 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2020.115578
CHEMBL5091373 222346 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5091373 222346 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5091373 222346 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5091373 222346 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5077293 221270 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5077293 221270 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5074880 221118 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5074880 221118 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
11431530 91400 0 None - 1 Guinea pig 5.1 pEC50 = 5.1 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 405 8 1 3 4.6 O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL222188 91400 0 None - 1 Guinea pig 5.1 pEC50 = 5.1 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 405 8 1 3 4.6 O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
24825775 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
24825775 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL5074190 221093 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5074190 221093 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
5 6927 72 None -9 27 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
5202 6927 72 None -9 27 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
CHEMBL39 6927 72 None -9 27 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
DB08839 6927 72 None -9 27 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00110
23643663 99619 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243744 99619 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
ChEMBL 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL5077293 221270 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5077293 221270 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
3233 10285 44 None 8511 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3247 10285 44 None 8511 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
6604889 10285 44 None 8511 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
CHEMBL282199 10285 44 None 8511 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
DB13988 10285 44 None 8511 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
4106 9280 22 None -7 7 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2019.126703
5358812 9280 22 None -7 7 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2019.126703
89 9280 22 None -7 7 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2019.126703
CHEMBL93240 9280 22 None -7 7 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2019.126703
3233 10285 44 None 8511 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3247 10285 44 None 8511 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
6604889 10285 44 None 8511 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
CHEMBL282199 10285 44 None 8511 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
DB13988 10285 44 None 8511 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3233 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2018.04.059
3247 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2018.04.059
6604889 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2018.04.059
CHEMBL282199 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2018.04.059
DB13988 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2018.04.059
3233 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3247 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
6604889 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
CHEMBL282199 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
DB13988 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3233 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3247 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
6604889 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
CHEMBL282199 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
DB13988 10285 44 None 8511 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
4106 9280 22 None -7 7 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
5358812 9280 22 None -7 7 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
89 9280 22 None -7 7 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
CHEMBL93240 9280 22 None -7 7 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
164609529 191243 0 None -36 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
CHEMBL4846823 191243 0 None -36 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
11391654 187304 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4753511 187304 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
127028798 144962 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 454 6 2 5 2.4 Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
CHEMBL3769612 144962 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 454 6 2 5 2.4 Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
142601335 193200 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
145946966 174376 0 None -144 3 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4209888 174376 0 None -144 3 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4300899 174376 0 None -144 3 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
142601335 193200 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
4106 9280 22 None -7 7 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112709
5358812 9280 22 None -7 7 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112709
89 9280 22 None -7 7 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112709
CHEMBL93240 9280 22 None -7 7 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112709
117209912 192116 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4859827 192116 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
117209912 192116 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4859827 192116 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
135339817 188263 0 None -1 5 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 437 6 0 5 4.2 CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O 10.1016/j.ejmech.2020.112709
CHEMBL4764679 188263 0 None -1 5 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
ChEMBL 437 6 0 5 4.2 CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O 10.1016/j.ejmech.2020.112709
206 9271 16 None -97 3 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm8014553
68848 9271 16 None -97 3 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm8014553
CHEMBL12314 9271 16 None -97 3 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm8014553
156013673 184040 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 293 1 2 2 2.9 CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4636148 184040 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 293 1 2 2 2.9 CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 10.1016/j.bmc.2020.115578
127028797 145111 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3771309 145111 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
11536844 121900 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343672 121900 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
213046 9164 59 None 1 17 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2021.113243
4168 9164 59 None 1 17 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2021.113243
7461 9164 59 None 1 17 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2021.113243
CHEMBL1237021 9164 59 None 1 17 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2021.113243
DB08815 9164 59 None 1 17 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2021.113243
142601318 192324 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863036 192324 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601318 192324 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863036 192324 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
11500509 127359 0 None 3 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343670 127359 0 None 3 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3545812 127359 0 None 3 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
117209962 191648 1 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4852622 191648 1 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
117209962 191648 1 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4852622 191648 1 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601343 192382 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863868 192382 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601343 192382 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863868 192382 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
127029652 145106 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3771222 145106 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
145947937 174502 0 None -32 4 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4207653 174502 0 None -32 4 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4302655 174502 0 None -32 4 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
134141985 153954 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3927929 153954 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
134141985 153954 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3927929 153954 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
44348383 23075 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 205 3 1 2 2.7 CSc1ccc2c(c1)C(CCN)=CC2 10.1016/j.ejmech.2012.11.042
CHEMBL122536 23075 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 205 3 1 2 2.7 CSc1ccc2c(c1)C(CCN)=CC2 10.1016/j.ejmech.2012.11.042
4106 9280 22 None -7 7 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2016.02.024
5358812 9280 22 None -7 7 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2016.02.024
89 9280 22 None -7 7 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2016.02.024
CHEMBL93240 9280 22 None -7 7 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2016.02.024
102364516 120320 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321794 120320 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
134157289 160860 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
CHEMBL3984812 160860 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
118709756 120324 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321798 120324 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
134157289 160860 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
CHEMBL3984812 160860 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
117209857 191917 1 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4856702 191917 1 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
142601328 191782 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
145946714 174337 0 None -30 4 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4213352 174337 0 None -30 4 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4300399 174337 0 None -30 4 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
142601328 191782 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
117209857 191917 1 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4856702 191917 1 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
127029650 145044 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770581 145044 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
142601333 192542 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4866412 192542 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
142601328 191782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
135367820 171600 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
142601333 192542 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4866412 192542 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
142601328 191782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
135367820 171600 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367405 170975 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367405 170975 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
156010865 183910 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4633786 183910 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
71574210 93058 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312934 93058 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
206 9271 16 None -97 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm500880c
68848 9271 16 None -97 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm500880c
CHEMBL12314 9271 16 None -97 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm500880c
3233 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
3247 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
6604889 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
CHEMBL282199 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
DB13988 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
3233 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
3247 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
6604889 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
CHEMBL282199 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
DB13988 10285 44 None 8511 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
2470 10425 50 None -5128 23 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2020.115578
3300 10425 50 None -5128 23 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2020.115578
5265 10425 50 None -5128 23 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2020.115578
99 10425 50 None -5128 23 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2020.115578
CHEMBL267930 10425 50 None -5128 23 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2020.115578
127028473 145051 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 451 6 2 6 1.6 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770639 145051 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 451 6 2 6 1.6 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2016.02.024
86288948 119403 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
CHEMBL3233679 119403 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
CHEMBL3302600 119403 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
71574302 93039 0 None -4 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312637 93039 0 None -4 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
142601323 192620 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4867560 192620 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
135367816 171614 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
117209971 193264 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4877051 193264 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
135367816 171614 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
142601323 192620 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4867560 192620 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
117209971 193264 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4877051 193264 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
117209918 193189 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4876036 193189 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
117209918 193189 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4876036 193189 1 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
11536843 121901 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343673 121901 0 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
22001618 88588 10 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL2164336 88588 10 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
59511191 192302 3 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4862745 192302 3 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
59511191 192302 3 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4862745 192302 3 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
2737389 194365 28 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL494675 194365 28 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
90656694 117772 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation
ChEMBL 339 7 1 4 3.4 CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262428 117772 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation
ChEMBL 339 7 1 4 3.4 CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
117209911 193108 1 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4874854 193108 1 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
117209911 193108 1 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4874854 193108 1 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
134154531 159507 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
CHEMBL3973160 159507 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
71574306 93041 0 None 2 2 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 10.1016/j.ejmech.2012.11.042
CHEMBL2312639 93041 0 None 2 2 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 10.1016/j.ejmech.2012.11.042
134154531 159507 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
CHEMBL3973160 159507 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
145947560 174487 0 None -19 4 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
CHEMBL4212812 174487 0 None -19 4 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
CHEMBL4302457 174487 0 None -19 4 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
11694810 127317 0 None -1 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3310123 127317 0 None -1 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3545474 127317 0 None -1 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
127028153 144941 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 456 7 2 6 1.8 COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
CHEMBL3769441 144941 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 456 7 2 6 1.8 COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
142601325 192648 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4868035 192648 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601325 192648 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4868035 192648 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
117209964 192913 1 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4871980 192913 1 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
134137104 149470 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
CHEMBL3892079 149470 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
134137104 149470 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
CHEMBL3892079 149470 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
117209964 192913 1 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4871980 192913 1 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
155510732 176299 0 None 1 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 430 6 1 1 6.9 Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.bmcl.2019.126703
CHEMBL4434876 176299 0 None 1 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
ChEMBL 430 6 1 1 6.9 Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.bmcl.2019.126703
142601329 193296 5 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4877603 193296 5 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
142601329 193296 5 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4877603 193296 5 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
124247485 170848 8 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
124247485 170848 8 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
142601337 192749 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4869695 192749 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601337 192749 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4869695 192749 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601335 193200 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
142601335 193200 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
67268994 170747 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
67268994 170747 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
71574212 93059 0 None -4 2 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312935 93059 0 None -4 2 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 10.1016/j.ejmech.2012.11.042
127028472 144949 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
CHEMBL3769534 144949 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
ChEMBL 470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
71574204 93042 0 None 18 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 10.1016/j.ejmech.2012.11.042
CHEMBL2312640 93042 0 None 18 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 10.1016/j.ejmech.2012.11.042
135367857 171383 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
135367857 171383 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
117209864 192813 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4870675 192813 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
117209864 192813 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4870675 192813 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
117209965 192026 1 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4858338 192026 1 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601341 192151 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4860503 192151 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
117209965 192026 1 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4858338 192026 1 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601341 192151 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4860503 192151 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
117209858 191333 1 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4848305 191333 1 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
117209858 191333 1 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4848305 191333 1 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
3233 10285 44 None - 2 Guinea pig 8.0 pKd = 8.0 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3247 10285 44 None - 2 Guinea pig 8.0 pKd = 8.0 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
6604889 10285 44 None - 2 Guinea pig 8.0 pKd = 8.0 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
CHEMBL282199 10285 44 None - 2 Guinea pig 8.0 pKd = 8.0 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
DB13988 10285 44 None - 2 Guinea pig 8.0 pKd = 8.0 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3233 10285 44 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3247 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
6604889 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
CHEMBL282199 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
DB13988 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3233 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3247 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
6604889 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
CHEMBL282199 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
DB13988 10285 44 None - 2 Guinea pig 7.8 pKd = 7.8 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
24768520 99782 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction
ChEMBL 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL244161 99782 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction
ChEMBL 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3247 10285 44 None - 2 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
6604889 10285 44 None - 2 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
CHEMBL282199 10285 44 None - 2 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
DB13988 10285 44 None - 2 Guinea pig 7.7 pKd = 7.7 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3233 10285 44 None - 2 Guinea pig 8.4 pKd = 8.4 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 8.4 pKd = 8.4 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 8.4 pKd = 8.4 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 8.4 pKd = 8.4 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 8.4 pKd = 8.4 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3247 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
6604889 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
CHEMBL282199 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
DB13988 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm800615e
3233 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 7.5 pKd = 7.5 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 8.2 pKd = 8.2 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 8.2 pKd = 8.2 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 8.2 pKd = 8.2 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 8.2 pKd = 8.2 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 8.2 pKd = 8.2 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3233 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
3247 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
6604889 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
CHEMBL282199 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
DB13988 10285 44 None - 2 Guinea pig 8.1 pKd = 8.1 Functional
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm070487n
118731356 124970 0 None - 0 Human 7.7 pKi = 7.7 Functional
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409039 124970 0 None - 0 Human 7.7 pKi = 7.7 Functional
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
4806 10780 88 None - 3 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
7351 10780 88 None - 3 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
9966051 10780 88 None - 3 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
CHEMBL2104993 10780 88 None - 3 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
DB09068 10780 88 None - 3 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
118731351 124966 0 None - 0 Human 8.2 pKi = 8.2 Functional
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409035 124966 0 None - 0 Human 8.2 pKi = 8.2 Functional
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
118731356 124970 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409039 124970 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
118731351 124966 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409035 124966 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
240 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
2769 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
44279790 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
660 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL1729 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL560739 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
DB00604 7731 43 None -1 23 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
4223 10764 94 None -562 15 Rat 8.3 pIC50 = 8.3 Functional
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
6918314 10764 94 None -562 15 Rat 8.3 pIC50 = 8.3 Functional
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
7427 10764 94 None -562 15 Rat 8.3 pIC50 = 8.3 Functional
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
CHEMBL439849 10764 94 None -562 15 Rat 8.3 pIC50 = 8.3 Functional
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
DB06684 10764 94 None -562 15 Rat 8.3 pIC50 = 8.3 Functional
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
135398737 7745 93 None -13 90 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
38 7745 93 None -13 90 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
722 7745 93 None -13 90 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL42 7745 93 None -13 90 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
DB00363 7745 93 None -13 90 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
3158 63041 27 None - 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1628227 63041 27 None - 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
2585 7590 103 None - 22 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 7590 103 None - 22 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 7590 103 None - 22 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 7590 103 None - 22 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 7590 103 None - 22 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2247 7293 81 None - 42 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 7293 81 None - 42 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 7293 81 None - 42 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 7293 81 None - 42 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 7293 81 None - 42 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2284 9956 33 None - 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
4926 9956 33 None - 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
7281 9956 33 None - 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL564 9956 33 None - 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00420 9956 33 None - 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
2337 10030 77 None -28 62 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
50 10030 77 None -28 62 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
5002 10030 77 None -28 62 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL716 10030 77 None -28 62 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
DB01224 10030 77 None -28 62 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
1890 9535 49 None - 16 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 9535 49 None - 16 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 9535 49 None - 16 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 9535 49 None - 16 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 9535 49 None - 16 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
212 10578 47 None -7 25 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 10578 47 None -7 25 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 10578 47 None -7 25 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 10578 47 None -7 25 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 10578 47 None -7 25 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2389 10104 118 None -8 66 Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
5073 10104 118 None -8 66 Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
96 10104 118 None -8 66 Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
CHEMBL85 10104 118 None -8 66 Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
DB00734 10104 118 None -8 66 Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
135 9310 43 None -83 56 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
1796 9310 43 None -83 56 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
4184 9310 43 None -83 56 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
CHEMBL6437 9310 43 None -83 56 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
DB06148 9310 43 None -83 56 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
2543 10479 68 None -93 32 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
5358 10479 68 None -93 32 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
54 10479 68 None -93 32 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
CHEMBL128 10479 68 None -93 32 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
DB00669 10479 68 None -93 32 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
191 7191 98 None -41 29 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 7191 98 None -41 29 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 7191 98 None -41 29 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 7191 98 None -41 29 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 7191 98 None -41 29 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
135398745 9688 112 None -95 65 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
47 9688 112 None -95 65 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
CHEMBL715 9688 112 None -95 65 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
DB00334 9688 112 None -95 65 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
1400 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
3658 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
7199 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
91513 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL896 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
DB00557 8738 70 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
2726 7706 68 None -13 72 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
621 7706 68 None -13 72 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
83 7706 68 None -13 72 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL71 7706 68 None -13 72 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB00477 7706 68 None -13 72 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1613 9127 53 None -23 44 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 9127 53 None -23 44 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 9127 53 None -23 44 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 9127 53 None -23 44 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 9127 53 None -23 44 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
135409453 10545 41 None - 2 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 10545 41 None - 2 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 10545 41 None - 2 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
1353 8692 93 None -263 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 8692 93 None -263 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 8692 93 None -263 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 8692 93 None -263 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 8692 93 None -263 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
392622 63086 95 None - 4 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 63086 95 None - 4 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
4106 9280 22 None -4 33 Human 9.2 pEC50 = 9.2 Binding
Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/np058114h
5358812 9280 22 None -4 33 Human 9.2 pEC50 = 9.2 Binding
Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/np058114h
89 9280 22 None -4 33 Human 9.2 pEC50 = 9.2 Binding
Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/np058114h
CHEMBL93240 9280 22 None -4 33 Human 9.2 pEC50 = 9.2 Binding
Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/np058114h
5 6927 72 None -3 53 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
5202 6927 72 None -3 53 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
CHEMBL39 6927 72 None -3 53 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
DB08839 6927 72 None -3 53 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
5 6927 72 None -3 53 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
5202 6927 72 None -3 53 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
CHEMBL39 6927 72 None -3 53 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
DB08839 6927 72 None -3 53 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2019.07.046
5 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.03.006
5202 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.03.006
CHEMBL39 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.03.006
DB08839 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.03.006
5 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.11.014
5202 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.11.014
CHEMBL39 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.11.014
DB08839 6927 72 None -3 53 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2016.11.014
5 6927 72 None -3 53 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
5202 6927 72 None -3 53 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
CHEMBL39 6927 72 None -3 53 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
DB08839 6927 72 None -3 53 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
72548703 168346 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 168346 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
5 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
5202 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
CHEMBL39 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
DB08839 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
5 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2013.03.016
5202 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2013.03.016
CHEMBL39 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2013.03.016
DB08839 6927 72 None -3 53 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2013.03.016
5 6927 72 None -3 53 Human 9.2 pIC50 = 9.2 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
5202 6927 72 None -3 53 Human 9.2 pIC50 = 9.2 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
CHEMBL39 6927 72 None -3 53 Human 9.2 pIC50 = 9.2 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
DB08839 6927 72 None -3 53 Human 9.2 pIC50 = 9.2 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
5 6927 72 None -3 53 Human 8.8 pIC50 = 8.8 Binding
Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm701575k
5202 6927 72 None -3 53 Human 8.8 pIC50 = 8.8 Binding
Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm701575k
CHEMBL39 6927 72 None -3 53 Human 8.8 pIC50 = 8.8 Binding
Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm701575k
DB08839 6927 72 None -3 53 Human 8.8 pIC50 = 8.8 Binding
Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm701575k
11430418 25558 12 None - 1 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 432 6 1 7 2.5 Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 10.1021/jm1002292
CHEMBL1278088 25558 12 None - 1 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 432 6 1 7 2.5 Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 10.1021/jm1002292
44452114 167582 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL411442 167582 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452114 167582 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL411442 167582 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
72197486 109280 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL2393245 109280 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL3040361 109280 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
49864602 22436 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 373 5 0 4 3.0 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2010.06.150
CHEMBL1222138 22436 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 373 5 0 4 3.0 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2010.06.150
44576978 194051 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.5 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL492793 194051 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.5 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
72197485 109266 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 348 4 2 4 3.6 Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL2393244 109266 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 348 4 2 4 3.6 Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL3040288 109266 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 348 4 2 4 3.6 Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
42635388 194477 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 471 8 1 5 3.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL495250 194477 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 471 8 1 5 3.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
44452277 102854 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260073 102854 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452245 102921 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260514 102921 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
44452251 103010 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
CHEMBL260901 103010 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
44452219 168016 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL411868 168016 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
54576142 73269 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 485 7 1 5 4.7 Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
CHEMBL1852341 73269 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 485 7 1 5 4.7 Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
CHEMBL3216098 73269 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 485 7 1 5 4.7 Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
24882509 103014 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260907 103014 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44452277 102854 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260073 102854 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452245 102921 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260514 102921 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
46232586 207701 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 473 9 0 4 4.6 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL601659 207701 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 473 9 0 4 4.6 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
44452251 103010 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
CHEMBL260901 103010 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
44452219 168016 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL411868 168016 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
135 9310 43 None -83 56 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(01)00721-1
1796 9310 43 None -83 56 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(01)00721-1
4184 9310 43 None -83 56 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(01)00721-1
CHEMBL6437 9310 43 None -83 56 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(01)00721-1
DB06148 9310 43 None -83 56 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(01)00721-1
46232818 207760 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 9 0 4 4.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL602060 207760 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 9 0 4 4.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
11113605 17279 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL116735 17279 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
44451927 102802 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL259776 102802 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44452038 103016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260969 103016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
155561990 182490 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 557 11 1 7 4.5 CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2019.111705
CHEMBL4582321 182490 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 557 11 1 7 4.5 CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2019.111705
24882509 103014 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260907 103014 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
42635204 194538 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL495678 194538 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
46232860 207840 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 494 10 0 6 3.9 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2009.12.067
CHEMBL602677 207840 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 494 10 0 6 3.9 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2009.12.067
44451927 102802 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL259776 102802 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452038 103016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260969 103016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
46232771 207634 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 443 10 0 5 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601249 207634 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 443 10 0 5 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
10067306 205645 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 363 5 0 5 3.1 CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 10.1016/j.bmc.2009.05.055
CHEMBL584046 205645 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 363 5 0 5 3.1 CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 10.1016/j.bmc.2009.05.055
46232622 207496 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 505 9 0 4 5.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL600012 207496 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 505 9 0 4 5.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
42635387 194471 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.6 O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL495212 194471 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.6 O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
46232773 207730 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 511 10 0 5 4.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601855 207730 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 511 10 0 5 4.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
44452278 102855 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260074 102855 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452039 103017 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260970 103017 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452278 102855 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260074 102855 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452039 103017 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260970 103017 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44451930 102538 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL258524 102538 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2007.11.049
44451930 102538 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL258524 102538 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.ejmech.2008.09.050
10472158 203604 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 335 4 1 5 2.5 NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 10.1016/j.bmc.2009.05.055
CHEMBL565745 203604 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 335 4 1 5 2.5 NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 10.1016/j.bmc.2009.05.055
44452223 102766 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
CHEMBL259625 102766 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
42388965 194314 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL494428 194314 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
44452223 102766 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
CHEMBL259625 102766 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
53320009 63437 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 435 3 0 5 3.4 CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 10.1016/j.bmcl.2010.12.007
CHEMBL1642116 63437 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 435 3 0 5 3.4 CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 10.1016/j.bmcl.2010.12.007
169713 86936 20 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 309 3 2 2 2.6 CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1 10.1016/j.bmcl.2009.09.002
CHEMBL21343 86936 20 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 309 3 2 2 2.6 CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1 10.1016/j.bmcl.2009.09.002
11047568 16828 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 396 9 0 4 4.0 CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 10.1021/jm010878g
CHEMBL115249 16828 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 396 9 0 4 4.0 CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 10.1021/jm010878g
10885636 117793 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL326263 117793 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
46232732 207704 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 431 9 0 4 3.4 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL601673 207704 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 431 9 0 4 3.4 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
44452276 166713 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
CHEMBL410722 166713 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
44452276 166713 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
CHEMBL410722 166713 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
12 8335 17 None -13 7 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1016/j.bmcl.2005.06.067
6918513 8335 17 None -13 7 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1016/j.bmcl.2005.06.067
CHEMBL267615 8335 17 None -13 7 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1016/j.bmcl.2005.06.067
46232653 207798 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 523 9 0 4 5.8 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL602284 207798 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 523 9 0 4 5.8 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
46232730 207670 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 9 0 4 4.5 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL601457 207670 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 9 0 4 4.5 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
72197484 109271 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 10.1016/j.ejmech.2013.02.020
CHEMBL2393243 109271 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 10.1016/j.ejmech.2013.02.020
CHEMBL3040324 109271 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 10.1016/j.ejmech.2013.02.020
18180076 22374 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 381 4 1 4 3.4 CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
CHEMBL1221497 22374 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 381 4 1 4 3.4 CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
44452247 102962 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260706 102962 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452115 103153 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL261742 103153 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
44451980 162800 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL406221 162800 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
44452115 103153 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL261742 103153 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
44451980 162800 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL406221 162800 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
44452247 102962 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260706 102962 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
46232690 207739 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 574 9 0 5 6.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL601886 207739 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 574 9 0 5 6.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
155568606 182887 0 None -3 2 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4591601 182887 0 None -3 2 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
155568606 182887 0 None -3 2 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4591601 182887 0 None -3 2 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
11957735 206800 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 350 4 1 5 4.0 CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1 10.1016/j.bmc.2009.07.007
CHEMBL595449 206800 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 350 4 1 5 4.0 CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1 10.1016/j.bmc.2009.07.007
46232589 207592 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 515 11 0 6 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL600822 207592 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 515 11 0 6 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
19426635 212372 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 280 2 1 3 3.1 CNCC1CC2c3ccccc3Cc3ccccc3N2O1 10.1016/s0960-894x(01)00721-1
CHEMBL81485 212372 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
ChEMBL 280 2 1 3 3.1 CNCC1CC2c3ccccc3Cc3ccccc3N2O1 10.1016/s0960-894x(01)00721-1
73351903 96470 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 360 3 2 4 3.1 Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
CHEMBL2376484 96470 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 360 3 2 4 3.1 Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
46232819 207933 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 493 10 0 5 4.5 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
CHEMBL603272 207933 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 493 10 0 5 4.5 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
44452166 102584 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL258785 102584 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452166 102584 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL258785 102584 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44452005 102720 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 10.1016/j.bmc.2007.11.049
CHEMBL259407 102720 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 10.1016/j.bmc.2007.11.049
44451954 167154 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL411105 167154 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452005 102720 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL259407 102720 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 10.1016/j.ejmech.2008.09.050
44451954 167154 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL411105 167154 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
46232559 207873 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 505 9 0 4 5.6 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL602882 207873 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 505 9 0 4 5.6 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
44452196 102804 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
CHEMBL259827 102804 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
44451953 103054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
CHEMBL261149 103054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
44452080 162556 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL405892 162556 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452144 103075 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL261232 103075 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
5 6927 72 None -3 53 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/np0205102
5202 6927 72 None -3 53 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/np0205102
CHEMBL39 6927 72 None -3 53 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/np0205102
DB08839 6927 72 None -3 53 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/np0205102
3233 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
3247 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
6604889 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
CHEMBL282199 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
DB13988 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
3233 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
3247 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
6604889 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
CHEMBL282199 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
DB13988 10285 44 None 2 12 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2019.07.046
42388639 194833 0 None -4 5 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2008.04.023
CHEMBL497749 194833 0 None -4 5 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2008.04.023
44452170 173768 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL428781 173768 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44452196 102804 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
CHEMBL259827 102804 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
44451953 103054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
CHEMBL261149 103054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
44452080 162556 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL405892 162556 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452144 103075 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL261232 103075 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
51003551 63444 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 449 3 0 5 3.8 CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.12.007
CHEMBL1642123 63444 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 449 3 0 5 3.8 CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.12.007
10907460 16600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 16600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
49864292 22367 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 471 6 0 4 5.0 CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
CHEMBL1221452 22367 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 471 6 0 4 5.0 CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
49864724 22464 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 409 5 0 4 3.8 CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.06.150
CHEMBL1222364 22464 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 409 5 0 4 3.8 CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.06.150
44452274 103011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260902 103011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
44452170 173768 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL428781 173768 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452274 103011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260902 103011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
11730467 17800 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL117537 17800 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
155531753 178425 0 None -1 2 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4465959 178425 0 None -1 2 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
155531753 178425 0 None -1 2 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4465959 178425 0 None -1 2 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
44451929 102838 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260003 102838 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44451929 102838 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260003 102838 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
42635570 194150 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1 10.1016/j.bmc.2008.04.023
CHEMBL493416 194150 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1 10.1016/j.bmc.2008.04.023
46232729 208235 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 574 9 0 5 6.3 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL604952 208235 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 574 9 0 5 6.3 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
44452139 102985 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 10.1016/j.bmc.2007.11.049
CHEMBL260804 102985 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 10.1016/j.bmc.2007.11.049
44452139 102985 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 10.1016/j.ejmech.2008.09.050
CHEMBL260804 102985 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 10.1016/j.ejmech.2008.09.050
44452302 103046 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261100 103046 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
46232689 207738 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 536 10 0 6 5.0 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2009.12.067
CHEMBL601885 207738 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 536 10 0 6 5.0 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2009.12.067
44452302 103046 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261100 103046 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44451957 165275 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL409107 165275 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44451957 165275 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL409107 165275 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
11304851 161384 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 426 4 3 8 3.7 O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2 10.1016/j.bmcl.2007.05.011
CHEMBL399203 161384 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 426 4 3 8 3.7 O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2 10.1016/j.bmcl.2007.05.011
44452143 103074 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL261231 103074 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452143 103074 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL261231 103074 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44451952 167152 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
CHEMBL411104 167152 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
44451952 167152 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
CHEMBL411104 167152 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
44452006 164280 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL407966 164280 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452006 164280 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL407966 164280 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452037 102972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260756 102972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
44452273 164916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL408717 164916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
46866711 22442 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 423 5 0 4 4.2 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12 10.1016/j.bmcl.2010.06.150
CHEMBL1222234 22442 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 423 5 0 4 4.2 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12 10.1016/j.bmcl.2010.06.150
42388975 199500 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL522006 199500 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1 10.1016/j.bmc.2008.04.023
44452037 102972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260756 102972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
44452273 164916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
CHEMBL408717 164916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
4106 9280 22 None -4 33 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2007.11.049
5358812 9280 22 None -4 33 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2007.11.049
89 9280 22 None -4 33 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2007.11.049
CHEMBL93240 9280 22 None -4 33 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2007.11.049
4223 10764 94 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1021/jm040793q
6918314 10764 94 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1021/jm040793q
7427 10764 94 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1021/jm040793q
CHEMBL439849 10764 94 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1021/jm040793q
DB06684 10764 94 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1021/jm040793q
10131112 8334 25 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 1 2 1 3.5 Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C 10.1016/j.bmcl.2005.06.067
8428 8334 25 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 1 2 1 3.5 Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C 10.1016/j.bmcl.2005.06.067
CHEMBL364005 8334 25 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 246 1 2 1 3.5 Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C 10.1016/j.bmcl.2005.06.067
49864289 22364 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 435 6 0 4 4.2 CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
CHEMBL1221449 22364 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 435 6 0 4 4.2 CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
73347306 96469 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 230 1 2 1 3.0 Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
CHEMBL2376483 96469 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 230 1 2 1 3.0 Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
46232772 207636 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 473 11 0 6 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601250 207636 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 473 11 0 6 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
46232977 207975 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 453 8 1 5 3.7 COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
CHEMBL603499 207975 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 453 8 1 5 3.7 COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
42389293 194313 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL494427 194313 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 439 8 1 5 3.3 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1 10.1016/j.bmc.2008.04.023
45278805 14222 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 484 7 1 4 5.2 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C 10.1016/j.bmcl.2010.01.093
CHEMBL1086754 14222 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 484 7 1 4 5.2 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C 10.1016/j.bmcl.2010.01.093
46232731 207671 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 481 9 0 4 4.3 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL601458 207671 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 481 9 0 4 4.3 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
42635029 194212 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL493810 194212 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
46232820 207631 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 531 9 0 4 5.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL601220 207631 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 531 9 0 4 5.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
44452357 102681 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL259236 102681 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
44452118 103128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261573 103128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
46232975 207876 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 482 9 0 5 4.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL602889 207876 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 482 9 0 5 4.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
44452357 102681 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL259236 102681 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44452118 103128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261573 103128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
46232978 207898 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 491 7 1 4 4.7 CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
CHEMBL603093 207898 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 491 7 1 4 4.7 CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
44451931 102539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL258525 102539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
11166042 173148 0 None 2 3 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL427518 173148 0 None 2 3 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2008.04.023
44451931 102539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL258525 102539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
73351905 96477 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 288 2 2 1 4.5 Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
CHEMBL2376491 96477 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 288 2 2 1 4.5 Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
42635571 194539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 421 8 1 5 2.7 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL495685 194539 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 421 8 1 5 2.7 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
42635572 194576 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 403 8 1 5 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL495890 194576 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 403 8 1 5 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2008.04.023
42635028 199994 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL523519 199994 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
49864723 22463 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 423 6 0 4 4.2 CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.06.150
CHEMBL1222363 22463 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 423 6 0 4 4.2 CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2010.06.150
44452329 165517 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL409358 165517 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452329 165517 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL409358 165517 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
45278882 14224 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 512 9 1 4 6.1 CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C 10.1016/j.bmcl.2010.01.093
CHEMBL1086756 14224 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 512 9 1 4 6.1 CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C 10.1016/j.bmcl.2010.01.093
46232654 207799 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 506 9 0 5 5.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL602285 207799 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 506 9 0 5 5.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
44452197 102848 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
CHEMBL260029 102848 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
44452081 102951 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260648 102951 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452008 102721 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL259408 102721 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452197 102848 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
CHEMBL260029 102848 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
44452081 102951 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260648 102951 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452171 175476 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL436700 175476 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
46232691 207740 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 524 9 0 5 5.2 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL601887 207740 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 524 9 0 5 5.2 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
11761059 16823 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 394 4 1 8 3.1 O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2 10.1021/jm010878g
CHEMBL115229 16823 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 394 4 1 8 3.1 O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2 10.1021/jm010878g
49864722 22462 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 395 4 0 4 3.4 CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
CHEMBL1222362 22462 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
ChEMBL 395 4 0 4 3.4 CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 10.1016/j.bmcl.2010.06.150
44452328 102856 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260076 102856 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452249 165329 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL409157 165329 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452171 175476 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL436700 175476 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452328 102856 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260076 102856 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452249 165329 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL409157 165329 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
46232560 207796 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 523 9 0 4 5.5 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL602274 207796 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 523 9 0 4 5.5 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
45109862 14206 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 470 7 2 3 5.2 Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2010.01.093
CHEMBL1086626 14206 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 470 7 2 3 5.2 Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2010.01.093
44452222 102724 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
CHEMBL259415 102724 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
44452222 102724 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
CHEMBL259415 102724 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
44452117 103127 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261572 103127 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
42389467 194215 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL493816 194215 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
44452217 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL259001 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
44452117 103127 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261572 103127 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
36418162 194341 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 423 8 1 4 3.3 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL494573 194341 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 423 8 1 4 3.3 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
637308 190687 37 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 314 6 2 5 2.9 COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O 10.1021/np050301s
CHEMBL481245 190687 37 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 314 6 2 5 2.9 COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O 10.1021/np050301s
10337743 10848 18 None - 1 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 347 5 0 5 2.6 CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C 10.1016/j.bmc.2009.05.055
8429 10848 18 None - 1 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 347 5 0 5 2.6 CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C 10.1016/j.bmc.2009.05.055
CHEMBL571858 10848 18 None - 1 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 347 5 0 5 2.6 CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C 10.1016/j.bmc.2009.05.055
44452217 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
CHEMBL259001 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
44452007 102673 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL259199 102673 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.ejmech.2008.09.050
73354882 96468 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 290 1 2 1 3.6 Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
CHEMBL2376482 96468 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 290 1 2 1 3.6 Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
44452007 102673 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL259199 102673 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 10.1016/j.bmc.2007.11.049
46232858 207562 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 481 9 0 4 4.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL600606 207562 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 481 9 0 4 4.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
45278883 14421 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 553 8 1 5 5.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1 10.1016/j.bmcl.2010.01.093
CHEMBL1088313 14421 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 553 8 1 5 5.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1 10.1016/j.bmcl.2010.01.093
72197668 109272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 360 5 2 5 3.5 COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL2393246 109272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 360 5 2 5 3.5 COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
CHEMBL3040325 109272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
ChEMBL 360 5 2 5 3.5 COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 10.1016/j.ejmech.2013.02.020
44451959 103055 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL261151 103055 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2007.11.049
44451984 103139 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
CHEMBL261653 103139 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
46232623 207518 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 535 10 0 5 5.6 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
CHEMBL600210 207518 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 535 10 0 5 5.6 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmc.2009.12.067
46232770 207620 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 458 10 0 6 3.2 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601037 207620 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 458 10 0 6 3.2 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
44451959 103055 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL261151 103055 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 10.1016/j.ejmech.2008.09.050
44451984 103139 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
CHEMBL261653 103139 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
44451986 166143 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL410042 166143 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44451986 166143 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL410042 166143 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
10407367 203572 0 None - 1 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 379 5 0 5 3.6 CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21 10.1016/j.bmc.2009.05.055
CHEMBL565552 203572 0 None - 1 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
ChEMBL 379 5 0 5 3.6 CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21 10.1016/j.bmc.2009.05.055
44452008 102721 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL259408 102721 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
45278886 14422 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 564 8 1 4 6.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2010.01.093
CHEMBL1088314 14422 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 564 8 1 4 6.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2010.01.093
46233014 207797 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 441 7 1 4 3.9 CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
CHEMBL602279 207797 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 441 7 1 4 3.9 CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
42389457 194512 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL495445 194512 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
44452193 102845 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260022 102845 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
44451982 103100 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
CHEMBL261434 103100 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
16 9033 8 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells
ChEMBL 462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9910021
9847194 9033 8 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells
ChEMBL 462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9910021
CHEMBL313714 9033 8 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells
ChEMBL 462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9910021
44452193 102845 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260022 102845 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
44451982 103100 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
CHEMBL261434 103100 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
46700867 182769 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins
ChEMBL 377 14 1 4 5.0 CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 10.1016/j.ejmech.2019.04.009
CHEMBL4588956 182769 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins
ChEMBL 377 14 1 4 5.0 CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 10.1016/j.ejmech.2019.04.009
42635205 194574 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL495884 194574 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
46232588 207736 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 485 10 0 5 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601872 207736 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 485 10 0 5 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
42635389 194148 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 433 9 1 6 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL493402 194148 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 433 9 1 6 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2008.04.023
44452275 103012 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
CHEMBL260903 103012 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.bmc.2007.11.049
44452298 103087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL261337 103087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44452275 103012 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
CHEMBL260903 103012 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C 10.1016/j.ejmech.2008.09.050
44452298 103087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL261337 103087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
46232861 207872 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 532 9 0 5 4.9 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL602878 207872 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 532 9 0 5 4.9 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
54577891 73349 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 471 6 1 5 4.3 Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
CHEMBL1852516 73349 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 471 6 1 5 4.3 Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
CHEMBL3216758 73349 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
ChEMBL 471 6 1 5 4.3 Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 10.1021/jm200682b
44451979 103099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
CHEMBL261433 103099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
72198754 97655 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor
ChEMBL 443 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 10.1016/j.ejmech.2013.01.044
CHEMBL2392349 97655 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor
ChEMBL 443 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 10.1016/j.ejmech.2013.01.044
53320010 63438 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 435 3 0 5 3.4 CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmcl.2010.12.007
CHEMBL1642117 63438 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
ChEMBL 435 3 0 5 3.4 CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmcl.2010.12.007
44451979 103099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
CHEMBL261433 103099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
185617 193333 86 None - 0 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 462 4 7 11 -0.2 O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O 10.1021/np0205102
CHEMBL487805 193333 86 None - 0 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 462 4 7 11 -0.2 O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O 10.1021/np0205102
44452279 168067 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
CHEMBL412153 168067 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
44452279 168067 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
CHEMBL412153 168067 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
44452331 102882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260249 102882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452331 102882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260249 102882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
46232976 207897 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 423 7 1 4 3.7 CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
CHEMBL603092 207897 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 423 7 1 4 3.7 CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmc.2009.12.067
10949380 170802 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 399 3 1 6 4.3 Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1 10.1021/jm010878g
CHEMBL420863 170802 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 399 3 1 6 4.3 Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1 10.1021/jm010878g
46232620 207615 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 553 10 0 5 5.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601022 207615 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 553 10 0 5 5.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
44452010 102765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.bmc.2007.11.049
CHEMBL259619 102765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.bmc.2007.11.049
44452141 103027 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL261018 103027 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44452010 102765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL259619 102765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.ejmech.2008.09.050
44452141 103027 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL261018 103027 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
42389129 199890 2 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 409 7 1 4 3.3 O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
CHEMBL522694 199890 2 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 409 7 1 4 3.3 O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2008.04.023
73356443 96476 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 294 2 2 2 4.6 Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
CHEMBL2376490 96476 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 294 2 2 2 4.6 Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 10.1016/j.ejmech.2013.03.006
44452221 102723 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
CHEMBL259414 102723 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
44452221 102723 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
CHEMBL259414 102723 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
44452199 102846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL260023 102846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
44452199 102846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL260023 102846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
11071079 117370 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL325516 117370 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
44452332 102883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL260250 102883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
44452362 103284 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL262589 103284 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.ejmech.2008.09.050
44452324 103013 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260906 103013 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452332 102883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL260250 102883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44452362 103284 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.bmc.2007.11.049
CHEMBL262589 103284 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 10.1016/j.bmc.2007.11.049
44452324 103013 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260906 103013 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452327 103047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
CHEMBL261102 103047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
46232859 207563 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 464 9 0 5 3.8 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
CHEMBL600607 207563 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 464 9 0 5 3.8 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 10.1016/j.bmc.2009.12.067
44452327 103047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
CHEMBL261102 103047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
10937901 16682 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 385 3 1 6 4.0 Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1 10.1021/jm010878g
CHEMBL114379 16682 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 385 3 1 6 4.0 Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1 10.1021/jm010878g
44452040 103018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL260971 103018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452041 103062 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261187 103062 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452040 103018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL260971 103018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452041 103062 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261187 103062 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452243 165327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
CHEMBL409156 165327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.bmc.2007.11.049
44452243 165327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL409156 165327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 10.1016/j.ejmech.2008.09.050
44452224 102767 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL259626 102767 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44452224 102767 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL259626 102767 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
44452246 102961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL260705 102961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.ejmech.2008.09.050
44342270 16702 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 355 3 1 4 4.5 Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 10.1021/jm010878g
CHEMBL114484 16702 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 355 3 1 4 4.5 Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 10.1021/jm010878g
44452246 102961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL260705 102961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 10.1016/j.bmc.2007.11.049
46232587 208363 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 500 10 0 6 4.4 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL605582 208363 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 500 10 0 6 4.4 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
46232652 207769 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 573 9 0 4 6.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
CHEMBL602087 207769 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 573 9 0 4 6.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 10.1016/j.bmc.2009.12.067
42635027 194176 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL493625 194176 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmc.2008.04.023
44452042 166943 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL410922 166943 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2008.09.050
44452167 102625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
CHEMBL258995 102625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.ejmech.2008.09.050
44452042 166943 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
CHEMBL410922 166943 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2007.11.049
44452167 102625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
CHEMBL258995 102625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 10.1016/j.bmc.2007.11.049
44452142 103028 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261019 103028 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
44452142 103028 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261019 103028 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452359 166145 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
CHEMBL410043 166145 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.bmc.2007.11.049
44452359 166145 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
CHEMBL410043 166145 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 10.1016/j.ejmech.2008.09.050
44452082 166179 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL410075 166179 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
46232817 207734 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 461 10 0 5 3.4 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL601859 207734 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 461 10 0 5 3.4 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1 10.1016/j.bmc.2009.12.067
44452082 166179 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL410075 166179 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
42389303 194213 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
CHEMBL493811 194213 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 419 9 1 6 2.2 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1 10.1016/j.bmc.2008.04.023
44452301 103045 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
CHEMBL261099 103045 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.ejmech.2008.09.050
44451985 103140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
CHEMBL261654 103140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.ejmech.2008.09.050
44452301 103045 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
CHEMBL261099 103045 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 10.1016/j.bmc.2007.11.049
44451985 103140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
CHEMBL261654 103140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 10.1016/j.bmc.2007.11.049
14748689 194052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 373 8 1 4 2.2 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 10.1016/j.bmc.2008.04.023
CHEMBL492794 194052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
ChEMBL 373 8 1 4 2.2 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 10.1016/j.bmc.2008.04.023
44452305 103084 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
CHEMBL261291 103084 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.bmc.2007.11.049
44452305 103084 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
CHEMBL261291 103084 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C 10.1016/j.ejmech.2008.09.050
44452078 102614 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 10.1016/j.bmc.2007.11.049
CHEMBL258956 102614 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 10.1016/j.bmc.2007.11.049
44452078 102614 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 10.1016/j.ejmech.2008.09.050
CHEMBL258956 102614 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 10.1016/j.ejmech.2008.09.050
44452195 163846 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 10.1016/j.ejmech.2008.09.050
CHEMBL407411 163846 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
ChEMBL 541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 10.1016/j.ejmech.2008.09.050
44452195 163846 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 10.1016/j.bmc.2007.11.049
CHEMBL407411 163846 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
ChEMBL 541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 10.1016/j.bmc.2007.11.049
46232621 208391 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 503 10 0 5 4.6 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
CHEMBL605787 208391 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 503 10 0 5 4.6 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1 10.1016/j.bmc.2009.12.067
3066250 77061 2 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 242 2 2 2 2.9 COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 10.1016/j.bmcl.2005.06.067
CHEMBL194305 77061 2 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
ChEMBL 242 2 2 2 2.9 COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 10.1016/j.bmcl.2005.06.067
11005810 17238 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL116463 17238 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
71061887 99893 0 None 66 2 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442996 99893 0 None 66 2 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
11785183 91488 0 None -1 4 Human 7.8 pKd = 7.8 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222755 91488 0 None -1 4 Human 7.8 pKd = 7.8 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
11224758 9132 5 None -4 6 Human 7.7 pKd = 7.7 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
8435 9132 5 None -4 6 Human 7.7 pKd = 7.7 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
CHEMBL225284 9132 5 None -4 6 Human 7.7 pKd = 7.7 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
11282296 150093 0 None -6 4 Human 7.6 pKd = 7.6 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL389718 150093 0 None -6 4 Human 7.6 pKd = 7.6 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
5 6927 72 None -3 53 Human 8.4 pKd = 8.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.08.023
5202 6927 72 None -3 53 Human 8.4 pKd = 8.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.08.023
CHEMBL39 6927 72 None -3 53 Human 8.4 pKd = 8.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.08.023
DB08839 6927 72 None -3 53 Human 8.4 pKd = 8.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.08.023
1809 6922 32 None -7 37 Human 7.5 pKd = 7.5 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
4 6922 32 None -7 37 Human 7.5 pKd = 7.5 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
CHEMBL18840 6922 32 None -7 37 Human 7.5 pKd = 7.5 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
11191128 91985 0 None -5 4 Human 7.2 pKd = 7.2 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL225512 91985 0 None -5 4 Human 7.2 pKd = 7.2 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
11432177 91897 0 None -1 4 Human 8.0 pKd = 8.0 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL224820 91897 0 None -1 4 Human 8.0 pKd = 8.0 Binding
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
3233 10285 44 None 2 12 Human 8.0 pKd = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2011.05.010
3247 10285 44 None 2 12 Human 8.0 pKd = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2011.05.010
6604889 10285 44 None 2 12 Human 8.0 pKd = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2011.05.010
CHEMBL282199 10285 44 None 2 12 Human 8.0 pKd = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2011.05.010
DB13988 10285 44 None 2 12 Human 8.0 pKd = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2011.05.010
1809 6922 32 None -2 37 Rat 10.5 pKi = 10.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm9911433
4 6922 32 None -2 37 Rat 10.5 pKi = 10.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm9911433
CHEMBL18840 6922 32 None -2 37 Rat 10.5 pKi = 10.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm9911433
56944082 118855 0 None 169 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 466 8 1 6 3.5 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3289972 118855 0 None 169 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 466 8 1 6 3.5 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
5 6927 72 None -3 53 Human 10.0 pKi = 10.0 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
5202 6927 72 None -3 53 Human 10.0 pKi = 10.0 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
CHEMBL39 6927 72 None -3 53 Human 10.0 pKi = 10.0 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
DB08839 6927 72 None -3 53 Human 10.0 pKi = 10.0 Binding
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2013.01.044
1809 6922 32 None -2 37 Rat 9.9 pKi = 9.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030826m
4 6922 32 None -2 37 Rat 9.9 pKi = 9.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030826m
CHEMBL18840 6922 32 None -2 37 Rat 9.9 pKi = 9.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030826m
5 6927 72 None -3 53 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm2006782
5202 6927 72 None -3 53 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm2006782
CHEMBL39 6927 72 None -3 53 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm2006782
DB08839 6927 72 None -3 53 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm2006782
23643664 9129 8 None -1 5 Rat 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
8434 9129 8 None -1 5 Rat 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
CHEMBL243954 9129 8 None -1 5 Rat 9.9 pKi = 9.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm070487n
42631003 206397 13 None 2 8 Human 9.8 pKi = 9.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1016/j.ejmech.2022.114464
CHEMBL592752 206397 13 None 2 8 Human 9.8 pKi = 9.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1016/j.ejmech.2022.114464
42631003 206397 13 None 2 8 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1021/acs.jmedchem.7b01898
CHEMBL592752 206397 13 None 2 8 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1021/acs.jmedchem.7b01898
168271260 197295 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 432 7 0 5 3.0 O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5179460 197295 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 432 7 0 5 3.0 O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1 10.1021/acs.jmedchem.2c00633
5 6927 72 None -3 53 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
5202 6927 72 None -3 53 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
CHEMBL39 6927 72 None -3 53 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
DB08839 6927 72 None -3 53 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.6b01422
10450593 131043 0 None 75 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2010.03.012
CHEMBL363452 131043 0 None 75 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2010.03.012
10450593 131043 0 None 75 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL363452 131043 0 None 75 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
66801551 118900 0 None 3 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 519 8 1 6 5.6 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3290016 118900 0 None 3 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 519 8 1 6 5.6 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
46224879 208326 3 None 1 7 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 302 2 0 2 4.6 Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
CHEMBL605405 208326 3 None 1 7 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 302 2 0 2 4.6 Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
168287666 198439 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 465 7 0 4 4.2 O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5196234 198439 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 465 7 0 4 4.2 O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.2c00633
11224758 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.03.005
8435 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.03.005
CHEMBL225284 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.03.005
11224758 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.12.041
8435 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.12.041
CHEMBL225284 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.12.041
11224758 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.08.023
8435 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.08.023
CHEMBL225284 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1016/j.ejmech.2014.08.023
11224758 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.5b00982
8435 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.5b00982
CHEMBL225284 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.5b00982
11224758 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.7b01898
8435 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.7b01898
CHEMBL225284 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/acs.jmedchem.7b01898
11224758 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
8435 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
CHEMBL225284 9132 5 None 4 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 10.1021/jm049702f
5 6927 72 None -3 53 Human 9.7 pKi = 9.7 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
5202 6927 72 None -3 53 Human 9.7 pKi = 9.7 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
CHEMBL39 6927 72 None -3 53 Human 9.7 pKi = 9.7 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
DB08839 6927 72 None -3 53 Human 9.7 pKi = 9.7 Binding
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm8007618
10402615 209296 0 None 20 3 Rat 9.6 pKi = 9.6 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 301 2 0 1 4.9 CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1021/jm030826m
CHEMBL611472 209296 0 None 20 3 Rat 9.6 pKi = 9.6 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 301 2 0 1 4.9 CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1021/jm030826m
42631003 206397 13 None 2 8 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
CHEMBL592752 206397 13 None 2 8 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
145989143 173965 0 None 2 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 399 5 1 2 5.3 Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2017.12.063
CHEMBL4291322 173965 0 None 2 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 399 5 1 2 5.3 Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2017.12.063
44393091 72131 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182923 72131 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393169 72370 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL183277 72370 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
71454999 88197 0 None 169 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 420 8 1 4 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159465 88197 0 None 169 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 420 8 1 4 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2012.07.043
1809 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm3003679
4 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm3003679
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm3003679
46233450 207022 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 357 6 0 1 6.5 CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2010.01.035
CHEMBL596959 207022 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 357 6 0 1 6.5 CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2010.01.035
10413595 168620 0 None -1 11 Human 9.5 pKi = 9.5 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
ChEMBL 499 4 1 5 2.5 COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
CHEMBL414628 168620 0 None -1 11 Human 9.5 pKi = 9.5 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
ChEMBL 499 4 1 5 2.5 COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
168283786 197649 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 465 7 0 4 4.2 O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5184712 197649 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 465 7 0 4 4.2 O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.2c00633
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.1c01093
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.07.029
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2016.01.043
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2014.07.026
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2014.07.026
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2014.07.026
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2014.07.026
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2014.07.026
3233 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
3247 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
6604889 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
CHEMBL282199 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
DB13988 10285 44 None 2 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.8b00642
1809 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112395
4 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112395
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2020.112395
11524413 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL261719 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
11589069 103022 0 None 10 8 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm070279v
CHEMBL260994 103022 0 None 10 8 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm070279v
11524413 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL261719 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
11524413 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL261719 103150 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
44126269 208263 5 None 2 6 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 318 3 0 2 4.5 Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 10.1016/j.bmcl.2009.11.037
CHEMBL605081 208263 5 None 2 6 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 318 3 0 2 4.5 Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 10.1016/j.bmcl.2009.11.037
1809 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0341204
4 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0341204
CHEMBL18840 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0341204
44393073 71237 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL181356 71237 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393092 71354 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL181605 71354 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393193 72415 0 None 32 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL183423 72415 0 None 32 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393192 73027 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL184607 73027 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
2389 10104 118 None -8 66 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2018.01.002
5073 10104 118 None -8 66 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2018.01.002
96 10104 118 None -8 66 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2018.01.002
CHEMBL85 10104 118 None -8 66 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2018.01.002
DB00734 10104 118 None -8 66 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2018.01.002
145985050 172469 0 None -3 5 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4245263 172469 0 None -3 5 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
1809 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2013.09.018
4 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2013.09.018
CHEMBL18840 6922 32 None -7 37 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.ejmech.2013.09.018
24854273 165151 0 None 112 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL408976 165151 0 None 112 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
56944763 118888 0 None 4 4 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3290004 118888 0 None 4 4 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
44266163 103830 1 None 4 2 Human 9.4 pKi = 9.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 387 4 1 2 4.4 O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL267062 103830 1 None 4 2 Human 9.4 pKi = 9.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 387 4 1 2 4.4 O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/s0960-894x(03)00077-5
24854273 165151 0 None 112 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL408976 165151 0 None 112 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
24854187 103002 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL260872 103002 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
24854187 103002 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL260872 103002 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
132578545 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3898250 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3991133 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
25192947 171445 0 None - 1 Human 9.3 pKi = 9.3 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 10.1016/j.ejmech.2019.111705
CHEMBL4216782 171445 0 None - 1 Human 9.3 pKi = 9.3 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 10.1016/j.ejmech.2019.111705
25192947 171445 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 10.1021/acs.jmedchem.7b01898
CHEMBL4216782 171445 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 10.1021/acs.jmedchem.7b01898
1809 6922 32 None -7 37 Human 9.3 pKi = 9.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0104264
4 6922 32 None -7 37 Human 9.3 pKi = 9.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0104264
CHEMBL18840 6922 32 None -7 37 Human 9.3 pKi = 9.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm0104264
11653869 103068 0 None 134 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm200547z
CHEMBL261209 103068 0 None 134 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm200547z
11653869 103068 0 None 134 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm070279v
CHEMBL261209 103068 0 None 134 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm070279v
16362 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1021/jm030030n
2172 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1021/jm030030n
90 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1021/jm030030n
CHEMBL1423 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1021/jm030030n
DB01100 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1021/jm030030n
213046 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2019.111736
4168 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2019.111736
7461 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2019.111736
CHEMBL1237021 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2019.111736
DB08815 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.ejmech.2019.111736
213046 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.bmc.2020.115459
4168 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.bmc.2020.115459
7461 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.bmc.2020.115459
CHEMBL1237021 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.bmc.2020.115459
DB08815 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1016/j.bmc.2020.115459
132578545 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3898250 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3991133 161337 0 None 33 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
66801167 118886 0 None 3 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
CHEMBL3290002 118886 0 None 3 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
1809 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
4 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
CHEMBL18840 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm800615e
1809 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
4 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
CHEMBL18840 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm070487n
44340836 168513 0 None 60 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 471 7 1 4 4.4 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL413707 168513 0 None 60 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 471 7 1 4 4.4 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1 10.1016/s0960-894x(02)00690-x
1809 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm020994z
4 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm020994z
CHEMBL18840 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm020994z
1809 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.bmc.2007.05.010
1809 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
4 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.bmc.2007.05.010
4 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
CHEMBL18840 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1016/j.bmc.2007.05.010
CHEMBL18840 6922 32 None -2 37 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm049702f
4106 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112149
5358812 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112149
89 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112149
CHEMBL93240 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2020.112149
145983405 173217 0 None 32 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4277476 173217 0 None 32 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
44266221 215145 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 405 4 0 3 4.5 O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9951 215145 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 405 4 0 3 4.5 O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
4106 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.1c00497
5358812 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.1c00497
89 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.1c00497
CHEMBL93240 9280 22 None -4 33 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.1c00497
25107716 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
8436 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
CHEMBL522691 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
25107716 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
8436 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
CHEMBL522691 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
25107716 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2014.03.005
8436 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2014.03.005
CHEMBL522691 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2014.03.005
25107716 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2012.07.043
8436 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2012.07.043
CHEMBL522691 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2012.07.043
25107716 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
8436 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
CHEMBL522691 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm800615e
23642275 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
8433 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
CHEMBL2164327 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
9881600 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.ejmech.2019.111705
CHEMBL161765 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.ejmech.2019.111705
44393180 73439 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL185384 73439 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
23642275 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
8433 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
CHEMBL2164327 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
9881600 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.ejmech.2019.111690
CHEMBL161765 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.ejmech.2019.111690
23642275 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2013.02.038
8433 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2013.02.038
CHEMBL2164327 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2013.02.038
9881600 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2003.11.050
CHEMBL161765 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2003.11.050
66803474 163095 0 None 3 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 429 6 2 3 4.2 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4065568 163095 0 None 3 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 429 6 2 3 4.2 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
11681111 127362 0 None 7 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 309 3 2 2 2.4 CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3343666 127362 0 None 7 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 309 3 2 2 2.4 CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3545815 127362 0 None 7 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 309 3 2 2 2.4 CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
4431 9506 25 None -20 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2014.08.023
73 9506 25 None -20 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2014.08.023
CHEMBL8618 9506 25 None -20 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2014.08.023
9881600 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmc.2010.01.035
CHEMBL161765 61971 4 None 8 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmc.2010.01.035
24854371 102650 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL259087 102650 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
23642275 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
8433 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
CHEMBL2164327 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
56933434 118874 0 None 6 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 431 7 1 5 3.8 Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289991 118874 0 None 6 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 431 7 1 5 3.8 Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
25107716 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1039/C8MD00313K
8436 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1039/C8MD00313K
CHEMBL522691 9130 43 None -3 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1039/C8MD00313K
24853955 162972 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL406414 162972 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
5 6927 72 None -5 53 Rat 9.2 pKi = 9.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030826m
5202 6927 72 None -5 53 Rat 9.2 pKi = 9.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030826m
CHEMBL39 6927 72 None -5 53 Rat 9.2 pKi = 9.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030826m
DB08839 6927 72 None -5 53 Rat 9.2 pKi = 9.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030826m
44437334 157277 0 None - 1 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 694 18 0 9 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL395444 157277 0 None - 1 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 694 18 0 9 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
24854371 102650 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL259087 102650 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
24854037 102649 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 7 1 3 5.2 CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL259086 102649 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 7 1 3 5.2 CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
24854041 102754 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm070279v
CHEMBL259549 102754 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm070279v
9934709 174603 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL430706 174603 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/s0960-894x(02)00690-x
9934709 174603 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/j.bmcl.2010.03.012
CHEMBL430706 174603 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/j.bmcl.2010.03.012
102364516 120320 0 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1016/j.ejmech.2019.111705
CHEMBL3321794 120320 0 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1016/j.ejmech.2019.111705
10015688 58448 1 None 12 4 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1 10.1016/j.bmcl.2003.11.050
CHEMBL158402 58448 1 None 12 4 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1 10.1016/j.bmcl.2003.11.050
10015688 58448 1 None 12 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1 10.1016/j.bmc.2010.01.035
CHEMBL158402 58448 1 None 12 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1 10.1016/j.bmc.2010.01.035
102364516 120320 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321794 120320 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 10.1021/jm500880c
66801263 118853 0 None 14 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 482 8 1 6 4.0 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289970 118853 0 None 14 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 482 8 1 6 4.0 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
66801210 118901 0 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 535 8 1 6 6.1 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12 10.1021/jm401895u
CHEMBL3290017 118901 0 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 535 8 1 6 6.1 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12 10.1021/jm401895u
44340854 16831 0 None 61 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 493 6 2 6 4.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL115262 16831 0 None 61 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 493 6 2 6 4.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(02)00690-x
3233 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2016.06.080
3247 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2016.06.080
6604889 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2016.06.080
CHEMBL282199 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2016.06.080
DB13988 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2016.06.080
3233 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.12.039
3247 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.12.039
6604889 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.12.039
CHEMBL282199 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.12.039
DB13988 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.12.039
3233 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2015.02.042
3247 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2015.02.042
6604889 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2015.02.042
CHEMBL282199 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2015.02.042
DB13988 10285 44 None 2 12 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2015.02.042
168297777 199683 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins
ChEMBL 398 8 0 4 3.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5184185 199683 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins
ChEMBL 398 8 0 4 3.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5222088 199683 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins
ChEMBL 398 8 0 4 3.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 10.1021/acs.jmedchem.2c00633
145974165 171367 0 None 8 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 410 5 0 2 6.0 Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl 10.1016/j.bmcl.2017.11.007
CHEMBL4215605 171367 0 None 8 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 410 5 0 2 6.0 Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl 10.1016/j.bmcl.2017.11.007
118717217 127354 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 325 4 2 3 1.6 COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3343667 127354 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 325 4 2 3 1.6 COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3545762 127354 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 325 4 2 3 1.6 COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
24829343 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1016/j.ejmech.2019.111705
CHEMBL409662 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1016/j.ejmech.2019.111705
24829343 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm200547z
CHEMBL409662 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm200547z
24829343 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm070279v
CHEMBL409662 165800 0 None 24 9 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 10.1021/jm070279v
145991084 173649 0 None 7 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 417 5 1 2 5.5 Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4285796 173649 0 None 7 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 417 5 1 2 5.5 Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
44340835 17180 0 None 117 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 499 7 1 4 5.0 O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL116292 17180 0 None 117 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 499 7 1 4 5.0 O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
155568606 182887 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4591601 182887 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
5 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.12.045
5202 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.12.045
CHEMBL39 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.12.045
DB08839 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.12.045
5 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm401895u
5202 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm401895u
CHEMBL39 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm401895u
DB08839 6927 72 None -3 53 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm401895u
66801158 118861 0 None -1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 464 8 1 6 3.9 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3289978 118861 0 None -1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 464 8 1 6 3.9 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
56944665 118887 0 None -1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
CHEMBL3290003 118887 0 None -1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
56944668 118889 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3290005 118889 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
25107518 194063 0 None 20 4 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 10.1021/jm800615e
CHEMBL492871 194063 0 None 20 4 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 10.1021/jm800615e
9971032 208984 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 282 2 1 1 4.0 Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C 10.1021/jm030826m
CHEMBL609675 208984 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 282 2 1 1 4.0 Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C 10.1021/jm030826m
44340850 16674 0 None 22 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 483 7 1 4 4.4 O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL114345 16674 0 None 22 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 483 7 1 4 4.4 O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
155516399 176850 0 None 47 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 368 6 1 5 3.1 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
CHEMBL4443201 176850 0 None 47 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 368 6 1 5 3.1 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
10069973 59173 0 None 4 4 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 407 9 0 6 4.4 COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1021/jm020994z
CHEMBL159022 59173 0 None 4 4 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 407 9 0 6 4.4 COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1021/jm020994z
155552188 180843 0 None 7 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 421 6 2 3 4.6 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1 10.1016/j.bmcl.2019.126703
CHEMBL4544153 180843 0 None 7 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 421 6 2 3 4.6 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1 10.1016/j.bmcl.2019.126703
1809 6922 32 None -7 37 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030030n
4 6922 32 None -7 37 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030030n
CHEMBL18840 6922 32 None -7 37 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm030030n
4106 9280 22 None -4 33 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
5358812 9280 22 None -4 33 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
89 9280 22 None -4 33 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
CHEMBL93240 9280 22 None -4 33 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm401895u
66801234 118878 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 469 7 1 5 4.3 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3289995 118878 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 469 7 1 5 4.3 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
66801271 118882 0 None 5 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 423 7 1 6 3.6 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3289999 118882 0 None 5 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 423 7 1 6 3.6 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 10.1021/jm401895u
66801139 118893 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 6 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 10.1021/jm401895u
CHEMBL3290009 118893 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 6 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 10.1021/jm401895u
23643870 99639 0 None 35 3 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243955 99639 0 None 35 3 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
44437328 97757 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 678 17 0 8 6.7 COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239656 97757 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 678 17 0 8 6.7 COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
1809 6922 32 None -7 37 Human 9.0 pKi = 9.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/acs.jmedchem.7b01898
4 6922 32 None -7 37 Human 9.0 pKi = 9.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/acs.jmedchem.7b01898
CHEMBL18840 6922 32 None -7 37 Human 9.0 pKi = 9.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/acs.jmedchem.7b01898
107 6929 121 None -1 31 Rat 9.0 pKi = 9.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030826m
1833 6929 121 None -1 31 Rat 9.0 pKi = 9.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030826m
CHEMBL8165 6929 121 None -1 31 Rat 9.0 pKi = 9.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030826m
25107520 194372 0 None 70 3 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1021/jm800615e
CHEMBL494709 194372 0 None 70 3 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1021/jm800615e
141745651 182125 0 None 1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 380 4 1 4 4.3 Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1 10.1016/j.bmcl.2019.126703
CHEMBL4574299 182125 0 None 1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 380 4 1 4 4.3 Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1 10.1016/j.bmcl.2019.126703
118713589 121151 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 6 0 5 4.0 Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331258 121151 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 6 0 5 4.0 Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
44393134 71623 0 None 39 2 Human 9.0 pKi = 9 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182071 71623 0 None 39 2 Human 9.0 pKi = 9 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
4184551 199440 9 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 352 5 1 4 2.7 CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 10.1016/j.bmcl.2021.128275
CHEMBL5218527 199440 9 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 352 5 1 4 2.7 CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 10.1016/j.bmcl.2021.128275
3233 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2010.11.078
3247 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2010.11.078
6604889 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2010.11.078
CHEMBL282199 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2010.11.078
DB13988 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2010.11.078
7059581 173824 3 None -1 2 Rat 9.0 pKi = 9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1016/s0960-894x(00)00166-9
CHEMBL428892 173824 3 None -1 2 Rat 9.0 pKi = 9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1016/s0960-894x(00)00166-9
3233 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00438-9
3247 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00438-9
6604889 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00438-9
CHEMBL282199 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00438-9
DB13988 10285 44 None 2 12 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00438-9
11725453 105856 0 None 1 6 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1016/s0960-894x(02)00438-9
CHEMBL28056 105856 0 None 1 6 Human 9.0 pKi = 9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1016/s0960-894x(02)00438-9
3233 10285 44 None -2 12 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm049743b
3247 10285 44 None -2 12 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm049743b
6604889 10285 44 None -2 12 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm049743b
CHEMBL282199 10285 44 None -2 12 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm049743b
DB13988 10285 44 None -2 12 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm049743b
7059581 173824 3 None -1 2 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm049743b
CHEMBL428892 173824 3 None -1 2 Rat 9.0 pKi = 9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm049743b
127025243 144521 0 None 60 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759205 144521 0 None 60 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1 10.1016/j.ejmech.2015.11.040
145985692 172223 0 None -3 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4239091 172223 0 None -3 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
118626161 172378 0 None -1 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4242858 172378 0 None -1 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
118626129 172421 0 None 3 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4243848 172421 0 None 3 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
156021386 184869 0 None 7 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
CHEMBL4647808 184869 0 None 7 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
4106 9280 22 None -4 33 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.7b00839
5358812 9280 22 None -4 33 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.7b00839
89 9280 22 None -4 33 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.7b00839
CHEMBL93240 9280 22 None -4 33 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/acs.jmedchem.7b00839
66803595 166507 0 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 431 6 3 4 3.6 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4104622 166507 0 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 431 6 3 4 3.6 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
155531753 178425 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4465959 178425 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
19605739 176791 14 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 204 3 3 2 1.4 NCCc1c[nH]c2ccc(C(=O)O)cc12 10.1016/j.ejmech.2019.111705
CHEMBL4442472 176791 14 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 204 3 3 2 1.4 NCCc1c[nH]c2ccc(C(=O)O)cc12 10.1016/j.ejmech.2019.111705
2389 10104 118 None -8 66 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm070516u
5073 10104 118 None -8 66 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm070516u
96 10104 118 None -8 66 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm070516u
CHEMBL85 10104 118 None -8 66 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm070516u
DB00734 10104 118 None -8 66 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm070516u
16006607 102447 4 None 10 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 219 2 2 4 2.1 CC(C)Oc1cccc2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
CHEMBL258075 102447 4 None 10 5 Human 9.0 pKi = 9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 219 2 2 4 2.1 CC(C)Oc1cccc2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
7059581 173824 3 None 1 2 Human 9.0 pKi = 9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm030841r
CHEMBL428892 173824 3 None 1 2 Human 9.0 pKi = 9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm030841r
11661471 166307 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 408 7 1 2 5.9 CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL410226 166307 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 408 7 1 2 5.9 CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
10346043 53894 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)
ChEMBL 503 5 2 5 3.4 COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
CHEMBL154274 53894 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)
ChEMBL 503 5 2 5 3.4 COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
10379532 106051 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1016/j.bmcl.2010.03.012
CHEMBL281923 106051 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1016/j.bmcl.2010.03.012
10062885 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm060959i
CHEMBL281924 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm060959i
78108787 198746 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant
ChEMBL 363 6 1 3 4.0 Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1 10.1021/acs.jmedchem.2c00633
CHEMBL5201016 198746 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant
ChEMBL 363 6 1 3 4.0 Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1 10.1021/acs.jmedchem.2c00633
10379532 106051 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm030030n
CHEMBL281923 106051 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm030030n
10062885 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm030030n
CHEMBL281924 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm030030n
10062885 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1016/j.bmc.2020.115578
CHEMBL281924 106052 0 None 1 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1016/j.bmc.2020.115578
10379532 106051 0 None -1 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL281923 106051 0 None -1 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
10062885 106052 0 None -1 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL281924 106052 0 None -1 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
24854044 104074 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm200547z
CHEMBL269083 104074 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm200547z
56944664 118850 0 None 23 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 428 8 1 6 3.0 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289968 118850 0 None 23 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 428 8 1 6 3.0 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 10.1021/jm401895u
56944764 118873 0 None 3 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 417 6 1 5 3.4 Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289990 118873 0 None 3 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 417 6 1 5 3.4 Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
23643663 99619 0 None 13 3 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243744 99619 0 None 13 3 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
145981875 173300 0 None 7 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 431 6 1 2 5.9 Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4278933 173300 0 None 7 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 431 6 1 2 5.9 Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
145992877 173675 0 None 11 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 413 6 1 2 5.7 Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2017.12.063
CHEMBL4286174 173675 0 None 11 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 413 6 1 2 5.7 Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2017.12.063
3044582 199192 2 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2 10.1016/j.ejmech.2022.114218
CHEMBL5208064 199192 2 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2 10.1016/j.ejmech.2022.114218
11524003 166306 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL410225 166306 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2009.06.038
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2009.06.038
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2009.06.038
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2009.06.038
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmcl.2009.06.038
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2011.09.044
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2011.09.044
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2011.09.044
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2011.09.044
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2011.09.044
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2012.07.043
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2012.07.043
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2012.07.043
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2012.07.043
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2012.07.043
118717211 127356 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 3 2 1.7 CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3343663 127356 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 3 2 1.7 CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3545801 127356 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 3 2 1.7 CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
11524003 166306 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL410225 166306 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
66801346 118876 0 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 485 7 1 5 4.8 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289993 118876 0 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 485 7 1 5 4.8 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
24854181 103207 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL262068 103207 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111705
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111705
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111705
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111705
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111705
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00690-x
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00690-x
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00690-x
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00690-x
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/s0960-894x(02)00690-x
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm991151j
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm991151j
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm991151j
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm991151j
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm991151j
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2013.02.038
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2013.02.038
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2013.02.038
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2013.02.038
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2013.02.038
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.7b01898
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.7b01898
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.7b01898
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.7b01898
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/acs.jmedchem.7b01898
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2014.08.023
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2014.08.023
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2014.08.023
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2014.08.023
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2014.08.023
3233 10285 44 None -2 12 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm0108505
3247 10285 44 None -2 12 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm0108505
6604889 10285 44 None -2 12 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm0108505
CHEMBL282199 10285 44 None -2 12 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm0108505
DB13988 10285 44 None -2 12 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm0108505
24825775 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030030n
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030030n
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030030n
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030030n
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030030n
15803947 59128 1 None 13 4 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 161 3 0 2 2.1 CN(C)CCSC(C)(C)C 10.1016/j.bmcl.2003.11.050
CHEMBL158973 59128 1 None 13 4 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 161 3 0 2 2.1 CN(C)CCSC(C)(C)C 10.1016/j.bmcl.2003.11.050
24825775 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3929 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
CHEMBL4205349 8305 14 None 346 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.1c00110
3233 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
3247 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
6604889 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
DB13988 10285 44 None 2 12 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.bmc.2016.09.019
118717223 127360 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 321 1 2 2 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343671 127360 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 321 1 2 2 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3545813 127360 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 321 1 2 2 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
56944859 118885 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
CHEMBL3290001 118885 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 10.1021/jm401895u
56944384 118898 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 521 8 1 6 5.8 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3290014 118898 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 521 8 1 6 5.8 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
66801565 118904 0 None 7 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 474 7 1 7 4.1 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3290020 118904 0 None 7 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 474 7 1 7 4.1 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
2389 10104 118 None -7 66 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm030030n
5073 10104 118 None -7 66 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm030030n
96 10104 118 None -7 66 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm030030n
CHEMBL85 10104 118 None -7 66 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm030030n
DB00734 10104 118 None -7 66 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm030030n
60196080 88582 2 None 12 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 252 2 1 2 3.1 Cc1ccccc1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
CHEMBL2164330 88582 2 None 12 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 252 2 1 2 3.1 Cc1ccccc1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
2737389 194365 28 None 53 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL494675 194365 28 None 53 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
11637931 127361 0 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 2 2 2.0 COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3343665 127361 0 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 2 2 2.0 COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3545814 127361 0 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 295 2 2 2 2.0 COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
5 6927 72 None -3 53 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.04.034
5202 6927 72 None -3 53 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.04.034
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.04.034
DB08839 6927 72 None -3 53 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2014.04.034
56944666 118890 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3290006 118890 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
2737389 194365 28 None 53 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1039/C8MD00313K
CHEMBL494675 194365 28 None 53 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
ChEMBL 238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1039/C8MD00313K
162643494 188428 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 437 7 1 5 3.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 10.1016/j.ejmech.2020.112149
CHEMBL4775997 188428 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 437 7 1 5 3.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 10.1016/j.ejmech.2020.112149
24854111 102534 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL258496 102534 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
66801229 118834 0 None -1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 452 6 1 6 3.6 O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3289952 118834 0 None -1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 452 6 1 6 3.6 O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
66800939 118835 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 466 7 1 6 3.9 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3289953 118835 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 466 7 1 6 3.9 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
56944667 118875 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 445 8 1 5 4.2 Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289992 118875 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 445 8 1 5 4.2 Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 10.1021/jm401895u
24854183 102677 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 413 7 1 3 4.6 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
CHEMBL259216 102677 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 413 7 1 3 4.6 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
CHEMBL5094234 222352 0 None 2 8 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096019 222352 0 None 2 8 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
134155116 157747 0 None 12 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3958215 157747 0 None 12 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL5091373 222346 0 None 1 9 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None 1 9 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
134155116 157747 0 None 12 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3958215 157747 0 None 12 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
132525570 170424 0 None 6 5 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes
ChEMBL 300 5 0 5 2.8 CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 10.1021/acs.jmedchem.7b01898
CHEMBL4204059 170424 0 None 6 5 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes
ChEMBL 300 5 0 5 2.8 CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 10.1021/acs.jmedchem.7b01898
56944565 118826 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 444 8 1 6 3.5 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289944 118826 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 444 8 1 6 3.5 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
56944383 118896 0 None -3 12 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3290012 118896 0 None -3 12 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
44437330 158968 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 706 19 0 8 7.5 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396844 158968 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 706 19 0 8 7.5 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
44266268 214576 0 None 10 2 Human 8.8 pKi = 8.8 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 394 5 0 3 3.8 O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9616 214576 0 None 10 2 Human 8.8 pKi = 8.8 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 394 5 0 3 3.8 O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
162652285 187054 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 399 7 1 5 3.1 Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1 10.1016/j.ejmech.2020.112149
CHEMBL4750664 187054 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 399 7 1 5 3.1 Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1 10.1016/j.ejmech.2020.112149
162654074 187358 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 10.1016/j.ejmech.2020.112149
CHEMBL4754138 187358 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 10.1016/j.ejmech.2020.112149
11500509 127359 0 None 3 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343670 127359 0 None 3 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3545812 127359 0 None 3 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
66801107 118823 0 None -1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 430 7 1 6 3.1 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289709 118823 0 None -1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 430 7 1 6 3.1 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
4106 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2018.04.059
5358812 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2018.04.059
89 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2018.04.059
CHEMBL93240 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2018.04.059
4106 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2023.117256
5358812 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2023.117256
89 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2023.117256
CHEMBL93240 9280 22 None -4 33 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2023.117256
118713592 121155 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 0 5 4.3 O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331261 121155 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 0 5 4.3 O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.08.023
11187960 73004 0 None 6 2 Rat 8.8 pKi = 8.8 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 337 7 0 2 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
CHEMBL184535 73004 0 None 6 2 Rat 8.8 pKi = 8.8 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 337 7 0 2 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
44437329 158379 0 None -8 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 692 18 0 8 7.1 COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396349 158379 0 None -8 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 692 18 0 8 7.1 COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
1809 6922 32 None -2 37 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm400766k
4 6922 32 None -2 37 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm400766k
CHEMBL18840 6922 32 None -2 37 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 10.1021/jm400766k
118717220 127358 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 305 1 2 1 2.9 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343669 127358 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 305 1 2 1 2.9 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3545811 127358 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 305 1 2 1 2.9 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
56944564 118836 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 480 8 1 6 4.3 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3289954 118836 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 480 8 1 6 4.3 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
24854185 164487 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 439 8 1 3 5.6 CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL408191 164487 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 439 8 1 3 5.6 CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
44340834 117002 0 None 169 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 494 6 1 6 4.0 O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL323778 117002 0 None 169 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 494 6 1 6 4.0 O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
155567938 182813 0 None 20 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 386 8 2 5 2.8 NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2019.111690
CHEMBL4590226 182813 0 None 20 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 386 8 2 5 2.8 NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2019.111690
10834268 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm0104264
CHEMBL428494 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm0104264
10834268 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm980519u
CHEMBL428494 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm980519u
168288462 198484 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 461 8 0 5 3.6 COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5196950 198484 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 461 8 0 5 3.6 COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 10.1021/acs.jmedchem.2c00633
60195993 88586 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 266 2 1 2 3.4 Cc1ccc(-c2ccccc2N2CCNCC2)cc1C 10.1021/jm3003679
CHEMBL2164334 88586 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 266 2 1 2 3.4 Cc1ccc(-c2ccccc2N2CCNCC2)cc1C 10.1021/jm3003679
3233 10285 44 None 2 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111690
3247 10285 44 None 2 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111690
6604889 10285 44 None 2 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111690
CHEMBL282199 10285 44 None 2 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111690
DB13988 10285 44 None 2 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1016/j.ejmech.2019.111690
56944383 118896 0 None -3 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3290012 118896 0 None -3 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
24854105 164712 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 401 6 1 3 4.5 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm070279v
CHEMBL408450 164712 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 401 6 1 3 4.5 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm070279v
155542678 179941 0 None 281 2 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 487 7 1 4 4.9 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2019.111705
CHEMBL4521657 179941 0 None 281 2 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 487 7 1 4 4.9 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2019.111705
10028436 10305 5 None 1 12 Rat 8.7 pKi = 8.7 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2004.11.013
3237 10305 5 None 1 12 Rat 8.7 pKi = 8.7 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2004.11.013
CHEMBL95104 10305 5 None 1 12 Rat 8.7 pKi = 8.7 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2004.11.013
44396223 130588 0 None 281 2 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 486 7 0 4 5.0 O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1021/jm0498102
CHEMBL362354 130588 0 None 281 2 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 486 7 0 4 5.0 O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1021/jm0498102
10573876 17234 0 None 199 7 Human 8.7 pKi = 8.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 414 5 0 3 3.7 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 10.1021/jm991151j
CHEMBL116448 17234 0 None 199 7 Human 8.7 pKi = 8.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 414 5 0 3 3.7 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 10.1021/jm991151j
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm991151j
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm991151j
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm991151j
44368731 126469 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 414 5 0 3 3.7 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 10.1021/jm030841r
CHEMBL347286 126469 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 414 5 0 3 3.7 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 10.1021/jm030841r
11047374 25681 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 388 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL12846 25681 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 388 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
10834268 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL428494 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
10834268 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm030841r
CHEMBL428494 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1021/jm030841r
10433930 57863 0 None -1 5 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
ChEMBL 449 5 2 5 3.9 COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
CHEMBL157910 57863 0 None -1 5 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
ChEMBL 449 5 2 5 3.9 COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1 10.1016/s0960-894x(00)00597-7
10028436 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/s0960-894x(02)00690-x
3237 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/s0960-894x(02)00690-x
CHEMBL95104 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/s0960-894x(02)00690-x
46203758 131326 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640556 131326 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 nan
44393072 176055 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 353 8 2 6 3.7 C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL441312 176055 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 353 8 2 6 3.7 C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
2389 10104 118 None -8 66 Human 8.0 pKi = 8 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
5073 10104 118 None -8 66 Human 8.0 pKi = 8 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
96 10104 118 None -8 66 Human 8.0 pKi = 8 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
CHEMBL85 10104 118 None -8 66 Human 8.0 pKi = 8 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
DB00734 10104 118 None -8 66 Human 8.0 pKi = 8 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
10171 6845 18 None -5 6 Rat 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/s0960-894x(00)00166-9
272 6845 18 None -5 6 Rat 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/s0960-894x(00)00166-9
CHEMBL274384 6845 18 None -5 6 Rat 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/s0960-894x(00)00166-9
10499156 120868 1 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm991151j
CHEMBL332701 120868 1 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm991151j
10249573 214372 0 None 1 11 Human 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
CHEMBL94984 214372 0 None 1 11 Human 8.0 pKi = 8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
44368705 52642 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1 10.1021/jm030841r
CHEMBL153156 52642 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1 10.1021/jm030841r
10596321 214243 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
CHEMBL94261 214243 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
44460708 212387 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
CHEMBL81607 212387 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
10249573 214372 0 None 1 11 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030030n
CHEMBL94984 214372 0 None 1 11 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030030n
44461065 212323 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 389 4 0 3 4.4 Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL81022 212323 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 389 4 0 3 4.4 Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
44460708 212387 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL81607 212387 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
10249573 214372 0 None -1 11 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm049743b
CHEMBL94984 214372 0 None -1 11 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm049743b
5 6927 72 None -5 53 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
5202 6927 72 None -5 53 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
CHEMBL39 6927 72 None -5 53 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
DB08839 6927 72 None -5 53 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
9894665 110590 1 None -30 8 Human 8.0 pKi = 8 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL309106 110590 1 None -30 8 Human 8.0 pKi = 8 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
46203758 131326 0 None - 1 Rat 8.0 pKi = 8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640556 131326 0 None - 1 Rat 8.0 pKi = 8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 nan
CHEMBL5074880 221118 0 None 1 9 Human 8.0 pKi = 8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
127028472 144949 0 None 9 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
CHEMBL3769534 144949 0 None 9 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2016.02.024
127038281 143865 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 494 10 0 6 4.0 Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 10.1016/j.bmc.2015.11.041
CHEMBL3747240 143865 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 494 10 0 6 4.0 Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 10.1016/j.bmc.2015.11.041
127041259 143876 0 None 4 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 420 8 0 6 2.7 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747459 143876 0 None 4 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 420 8 0 6 2.7 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1 10.1016/j.bmc.2015.11.041
145985505 172404 0 None -3 5 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4243579 172404 0 None -3 5 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
134145903 155657 0 None 5 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.9 C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL3941529 155657 0 None 5 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.9 C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1016/j.ejmech.2016.05.005
71456781 88203 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 3.8 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159471 88203 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 3.8 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
71458651 88209 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 439 8 1 5 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159477 88209 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 439 8 1 5 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1 10.1016/j.ejmech.2012.07.043
71456784 88224 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159492 88224 0 None 1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
242 7258 124 None -15 51 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2022.114193
34 7258 124 None -15 51 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2022.114193
60795 7258 124 None -15 51 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2022.114193
CHEMBL1112 7258 124 None -15 51 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2022.114193
DB01238 7258 124 None -15 51 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2022.114193
118731352 124967 0 None 2 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 510 9 1 4 4.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409036 124967 0 None 2 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 510 9 1 4 4.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
118731362 124976 0 None 4 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 564 8 0 4 5.6 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409045 124976 0 None 4 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 564 8 0 4 5.6 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
145947590 174484 0 None 8 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 516 7 2 6 2.4 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4170657 174484 0 None 8 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 516 7 2 6 2.4 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4302436 174484 0 None 8 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 516 7 2 6 2.4 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
145947976 174493 0 None 41 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 438 7 2 6 1.6 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4168743 174493 0 None 41 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 438 7 2 6 1.6 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4302539 174493 0 None 41 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 438 7 2 6 1.6 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
56944952 164146 0 None -2 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 447 7 2 3 4.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4077937 164146 0 None -2 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 447 7 2 3 4.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
24854103 102930 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm200547z
CHEMBL260551 102930 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm200547z
127052458 147518 0 None 3 7 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818056 147518 0 None 3 7 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 10.1016/j.bmc.2016.05.053
90644074 118849 0 None 151 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 414 7 1 6 2.6 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289967 118849 0 None 151 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 414 7 1 6 2.6 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1 10.1021/jm401895u
56943695 118899 0 None -4 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 505 7 1 6 5.2 Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3290015 118899 0 None -4 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 505 7 1 6 5.2 Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
10171 6845 18 None -11 6 Human 8.0 pKi = 8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030841r
272 6845 18 None -11 6 Human 8.0 pKi = 8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030841r
CHEMBL274384 6845 18 None -11 6 Human 8.0 pKi = 8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030841r
90656682 117755 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 311 6 2 4 3.0 Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262411 117755 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 311 6 2 4 3.0 Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
11525867 103001 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm070279v
CHEMBL260870 103001 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm070279v
44266289 104939 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 404 4 1 5 3.5 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL273872 104939 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 404 4 1 5 3.5 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
127052458 147518 0 None 3 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818056 147518 0 None 3 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 10.1016/j.bmc.2016.05.053
242 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2021.113243
34 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2021.113243
60795 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2021.113243
CHEMBL1112 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2021.113243
DB01238 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2021.113243
242 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2020.115943
34 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2020.115943
60795 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2020.115943
CHEMBL1112 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2020.115943
DB01238 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2020.115943
242 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2016.05.053
34 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2016.05.053
60795 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2016.05.053
CHEMBL1112 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2016.05.053
DB01238 7258 124 None -15 51 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2016.05.053
10714877 121149 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 6 3.2 COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331256 121149 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 6 3.2 COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
11825614 109387 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 403 6 1 3 4.5 Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL304167 109387 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 403 6 1 3 4.5 Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
46204726 131345 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
CHEMBL3640574 131345 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
46204726 131345 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
CHEMBL3640574 131345 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
134155476 158004 0 None 7 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.9 C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL3960056 158004 0 None 7 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.9 C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1016/j.ejmech.2016.05.005
2726 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
621 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
83 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
CHEMBL71 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
DB00477 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
76336186 113179 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121435 113179 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139448 113179 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
11667458 72773 0 None 5 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 350 6 1 4 3.1 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1 10.1021/jm200547z
CHEMBL1836788 72773 0 None 5 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 350 6 1 4 3.1 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1 10.1021/jm200547z
11407754 104957 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL273982 104957 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
49850870 63163 0 None -794 9 Human 7.0 pKi = 7 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 424 6 1 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1631535 63163 0 None -794 9 Human 7.0 pKi = 7 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 424 6 1 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm100714c
242 7258 124 None -15 51 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
34 7258 124 None -15 51 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
60795 7258 124 None -15 51 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
CHEMBL1112 7258 124 None -15 51 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
DB01238 7258 124 None -15 51 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
135398737 7745 93 None -13 90 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
38 7745 93 None -13 90 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
722 7745 93 None -13 90 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
CHEMBL42 7745 93 None -13 90 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
DB00363 7745 93 None -13 90 Human 7.0 pKi = 7 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
11407754 104957 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
CHEMBL273982 104957 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
44374234 62329 0 None 12 2 Human 7.0 pKi = 7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1ccnc(-c2ccccc2)c1 10.1016/j.bmcl.2003.11.050
CHEMBL162071 62329 0 None 12 2 Human 7.0 pKi = 7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1ccnc(-c2ccccc2)c1 10.1016/j.bmcl.2003.11.050
10737314 104046 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL268921 104046 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
10737314 104046 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
CHEMBL268921 104046 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
11166042 173148 0 None -2 3 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1021/jm049743b
CHEMBL427518 173148 0 None -2 3 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1021/jm049743b
135 9310 43 None -50 56 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
1796 9310 43 None -50 56 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
4184 9310 43 None -50 56 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
CHEMBL6437 9310 43 None -50 56 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
DB06148 9310 43 None -50 56 Rat 7.0 pKi = 7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
CHEMBL5071978 221051 0 None -1 6 Human 7.0 pKi = 7 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
127041874 143825 0 None -2 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 450 8 0 4 4.5 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2015.11.041
CHEMBL3746713 143825 0 None -2 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 450 8 0 4 4.5 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2015.11.041
145975905 170607 0 None 5 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 376 4 1 4 2.4 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4206366 170607 0 None 5 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 376 4 1 4 2.4 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2 10.1016/j.bmcl.2018.06.019
11414582 188117 0 None -16 4 Rat 7.0 pKi = 7 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 271 2 1 3 2.7 Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4762886 188117 0 None -16 4 Rat 7.0 pKi = 7 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 271 2 1 3 2.7 Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
2470 10425 50 None -1258 58 Human 7.0 pKi = 7 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.ejmech.2019.111705
3300 10425 50 None -1258 58 Human 7.0 pKi = 7 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.ejmech.2019.111705
5265 10425 50 None -1258 58 Human 7.0 pKi = 7 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.ejmech.2019.111705
99 10425 50 None -1258 58 Human 7.0 pKi = 7 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.ejmech.2019.111705
CHEMBL267930 10425 50 None -1258 58 Human 7.0 pKi = 7 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.ejmech.2019.111705
44439409 97991 0 None 15 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 322 5 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL240025 97991 0 None 15 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 322 5 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21 10.1016/j.bmcl.2007.01.093
44439404 98560 0 None 15 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 334 3 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL241103 98560 0 None 15 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 334 3 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
21509921 111235 0 None -9 24 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 111235 0 None -9 24 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
11808247 24847 0 None -1 9 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 285 5 0 2 3.7 Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL126667 24847 0 None -1 9 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 285 5 0 2 3.7 Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819366 24847 0 None -1 9 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 285 5 0 2 3.7 Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
9888211 28188 13 None -125 10 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 417 6 1 3 4.5 O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 10.1021/jm070516u
CHEMBL131495 28188 13 None -125 10 Human 7.0 pKi = 7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 417 6 1 3 4.5 O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 10.1021/jm070516u
10317515 106535 2 None -19 3 Rat 7.0 pKi = 7 Binding
Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand
ChEMBL 378 3 0 4 1.8 O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 10.1016/s0960-894x(03)00160-4
CHEMBL285066 106535 2 None -19 3 Rat 7.0 pKi = 7 Binding
Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand
ChEMBL 378 3 0 4 1.8 O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 10.1016/s0960-894x(03)00160-4
46204086 131333 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 nan
CHEMBL3640562 131333 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 nan
11327643 126360 0 None 1 2 Human 6.0 pKi = 6 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL346191 126360 0 None 1 2 Human 6.0 pKi = 6 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2019.06.028
240 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
2769 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
44279790 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
660 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
CHEMBL1729 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
CHEMBL560739 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
DB00604 7731 43 None -199 25 Human 6.0 pKi = 6 Binding
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1016/j.bmcl.2013.05.018
135398745 9688 112 None -95 65 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
47 9688 112 None -95 65 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
CHEMBL715 9688 112 None -95 65 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
DB00334 9688 112 None -95 65 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
2337 10030 77 None -28 62 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
50 10030 77 None -28 62 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
5002 10030 77 None -28 62 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
CHEMBL716 10030 77 None -28 62 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
DB01224 10030 77 None -28 62 Human 6.0 pKi = 6 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
11327643 126360 0 None -1 2 Rat 6.0 pKi = 6 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
CHEMBL346191 126360 0 None -1 2 Rat 6.0 pKi = 6 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
9827938 18543 0 None -39 12 Human 6.0 pKi = 6 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 517 13 1 3 6.3 CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 10.1016/j.bmcl.2005.06.024
CHEMBL1181680 18543 0 None -39 12 Human 6.0 pKi = 6 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 517 13 1 3 6.3 CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 10.1016/j.bmcl.2005.06.024
CHEMBL188486 18543 0 None -39 12 Human 6.0 pKi = 6 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 517 13 1 3 6.3 CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 10.1016/j.bmcl.2005.06.024
46204086 131333 0 None - 1 Rat 6.0 pKi = 6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 nan
CHEMBL3640562 131333 0 None - 1 Rat 6.0 pKi = 6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 nan
10125797 168590 9 None -407 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
CHEMBL41436 168590 9 None -407 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
CHEMBL541621 168590 9 None -407 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
153287574 182026 0 None -13 10 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 266 2 1 2 4.0 CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
CHEMBL4572167 182026 0 None -13 10 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 266 2 1 2 4.0 CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
146709966 182558 0 None -338 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 241 1 1 2 3.4 CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
CHEMBL4583909 182558 0 None -338 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 241 1 1 2 3.4 CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
153287539 182853 0 None -3 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 265 1 1 2 3.6 C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4591008 182853 0 None -3 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 265 1 1 2 3.6 C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
2543 10479 68 None -93 32 Human 6.0 pKi = 6 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1016/j.ejmech.2019.111705
5358 10479 68 None -93 32 Human 6.0 pKi = 6 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1016/j.ejmech.2019.111705
54 10479 68 None -93 32 Human 6.0 pKi = 6 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1016/j.ejmech.2019.111705
CHEMBL128 10479 68 None -93 32 Human 6.0 pKi = 6 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1016/j.ejmech.2019.111705
DB00669 10479 68 None -93 32 Human 6.0 pKi = 6 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1016/j.ejmech.2019.111705
44439403 98559 0 None -5 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 394 5 0 5 4.0 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL241102 98559 0 None -5 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 394 5 0 5 4.0 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2 10.1016/j.bmcl.2007.01.093
76524414 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819434 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819713 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
9913554 107769 0 None -1258 14 Human 6.0 pKi = 6 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 10.1016/s0960-894x(02)00172-5
CHEMBL29433 107769 0 None -1258 14 Human 6.0 pKi = 6 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 10.1016/s0960-894x(02)00172-5
46204732 131349 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 250 3 1 3 2.6 N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 nan
CHEMBL3640578 131349 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 250 3 1 3 2.6 N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 nan
46204734 131352 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 264 3 1 3 2.9 Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 nan
CHEMBL3640580 131352 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 264 3 1 3 2.9 Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 nan
46205044 131357 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 297 5 1 3 3.8 Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 nan
CHEMBL3640585 131357 0 None - 1 Rat 5.0 pKi = 5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 297 5 1 3 3.8 Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 nan
10668422 104941 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 395 6 1 3 4.3 O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL273890 104941 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 395 6 1 3 4.3 O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
10643153 105299 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
CHEMBL276255 105299 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
46204732 131349 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 250 3 1 3 2.6 N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 nan
CHEMBL3640578 131349 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 250 3 1 3 2.6 N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 nan
46204734 131352 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 264 3 1 3 2.9 Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 nan
CHEMBL3640580 131352 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 264 3 1 3 2.9 Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 nan
46205044 131357 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 297 5 1 3 3.8 Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 nan
CHEMBL3640585 131357 0 None - 1 Rat 5.0 pKi = 5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 297 5 1 3 3.8 Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 nan
13149 9323 36 None -165 17 Human 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.1c00726
3034396 9323 36 None -165 17 Human 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.1c00726
CHEMBL299031 9323 36 None -165 17 Human 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.1c00726
11462900 63784 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 372 4 1 3 4.7 FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644270 63784 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 372 4 1 3 4.7 FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
53316608 63790 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 344 3 1 2 5.1 CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644276 63790 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 344 3 1 2 5.1 CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
53316609 63791 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 10.1016/j.bmcl.2010.11.078
CHEMBL1644277 63791 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 10.1016/j.bmcl.2010.11.078
11449570 63795 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 304 3 2 3 3.6 Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644281 63795 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 304 3 2 3 3.6 Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
3251 10844 58 None -33113 12 Human 5.0 pKi = 5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm1009956
5684 10844 58 None -33113 12 Human 5.0 pKi = 5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm1009956
80 10844 58 None -33113 12 Human 5.0 pKi = 5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm1009956
CHEMBL31354 10844 58 None -33113 12 Human 5.0 pKi = 5 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm1009956
44368373 126336 0 None - 1 Human 4.0 pKi = 4 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
CHEMBL345971 126336 0 None - 1 Human 4.0 pKi = 4 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
10668422 104941 0 None - 1 Human 4.0 pKi = 4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 395 6 1 3 4.3 O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 10.1021/jm030841r
CHEMBL273890 104941 0 None - 1 Human 4.0 pKi = 4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 395 6 1 3 4.3 O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 10.1021/jm030841r
CHEMBL5282788 200951 0 None -1 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 422 7 0 5 3.5 O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmc.2023.117256
76524414 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819434 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819713 147647 0 None -77 8 Human 6.0 pKi = 6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 426 6 1 4 5.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
118724647 127384 0 None -5 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 381 6 0 7 1.7 Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3361004 127384 0 None -5 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 381 6 0 7 1.7 Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546104 127384 0 None -5 4 Human 6.0 pKi = 6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 381 6 0 7 1.7 Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
11603887 109367 0 None -3 2 Rat 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 407 10 1 4 3.5 O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 10.1021/jm400766k
CHEMBL2431046 109367 0 None -3 2 Rat 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 407 10 1 4 3.5 O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 10.1021/jm400766k
CHEMBL3040877 109367 0 None -3 2 Rat 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 407 10 1 4 3.5 O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 10.1021/jm400766k
90654670 116868 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 427 9 1 6 2.4 NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235742 116868 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 427 9 1 6 2.4 NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
136180321 124493 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 4 4.1 O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401483 124493 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 4 4.1 O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
11291892 140291 3 None -24 3 Rat 7.0 pKi = 7 Binding
In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes
ChEMBL 378 3 0 4 1.8 O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm048999e
CHEMBL370758 140291 3 None -24 3 Rat 7.0 pKi = 7 Binding
In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes
ChEMBL 378 3 0 4 1.8 O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm048999e
10994400 211900 0 None -109 4 Human 7.0 pKi = 7 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 439 5 1 2 4.4 OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 10.1021/jm0200411
CHEMBL77855 211900 0 None -109 4 Human 7.0 pKi = 7 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 439 5 1 2 4.4 OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 10.1021/jm0200411
2880253 169486 9 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 7 1 2 5.4 CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1 10.1016/j.ejmech.2018.04.010
CHEMBL4170813 169486 9 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 7 1 2 5.4 CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1 10.1016/j.ejmech.2018.04.010
71457409 89737 0 None -3981 6 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 461 5 0 4 4.9 CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 10.1021/jm300943r
CHEMBL2181168 89737 0 None -3981 6 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 461 5 0 4 4.9 CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 10.1021/jm300943r
134147951 156583 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 271 5 0 3 3.4 COc1ccccc1-c1cc(CN(C)C)ccc1OC 10.1016/j.ejmech.2016.07.029
CHEMBL3948597 156583 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 271 5 0 3 3.4 COc1ccccc1-c1cc(CN(C)C)ccc1OC 10.1016/j.ejmech.2016.07.029
10737314 104046 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
CHEMBL268921 104046 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
CHEMBL5076882 221245 0 None -26 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
CHEMBL5083505 221645 0 None -2 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(F)c1 10.1021/acs.jmedchem.1c00497
1534 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
9287 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
CHEMBL30713 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
10314060 175379 0 None -72 6 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 322 4 1 4 2.9 COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 10.1016/s0960-894x(01)00241-4
CHEMBL435949 175379 0 None -72 6 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 322 4 1 4 2.9 COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 10.1016/s0960-894x(01)00241-4
122442272 145126 0 None -40 15 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3769968 145126 0 None -40 15 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3771384 145126 0 None -40 15 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
18137015 171119 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4212558 171119 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
23369457 196294 2 None -2 2 Human 6.0 pKi = 6.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 322 4 1 4 2.2 O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL514058 196294 2 None -2 2 Human 6.0 pKi = 6.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 322 4 1 4 2.2 O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
10754042 106576 0 None 2 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 263 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O 10.1021/jm9911433
CHEMBL285352 106576 0 None 2 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 263 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O 10.1021/jm9911433
1534 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
9287 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
CHEMBL30713 109817 53 None 1 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2013.03.066
134135372 151175 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 295 4 0 2 4.6 COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3906019 151175 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 295 4 0 2 4.6 COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1 10.1016/j.ejmech.2016.07.029
168291659 198817 0 None -14 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 356 8 3 8 1.4 Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5202120 198817 0 None -14 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 356 8 3 8 1.4 Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
135414318 214564 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 298 0 1 5 3.1 CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1 10.1021/jm030030n
CHEMBL96055 214564 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 298 0 1 5 3.1 CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1 10.1021/jm030030n
145978146 170695 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 450 9 2 5 3.1 CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4207310 170695 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 450 9 2 5 3.1 CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
156013326 184273 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 350 4 1 4 3.8 COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4639400 184273 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 350 4 1 4 3.8 COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
124247485 170848 8 None -1 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None -1 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
124247485 170848 8 None -1 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4209274 170848 8 None -1 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
2950739 169742 10 None -4 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 9 1 4 4.6 COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL4174845 169742 10 None -4 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 9 1 4 4.6 COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1 10.1016/j.ejmech.2018.04.010
57403525 76929 0 None -691 10 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 361 6 1 2 4.8 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940402 76929 0 None -691 10 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 361 6 1 2 4.8 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
21533446 76930 0 None -281 10 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940403 76930 0 None -281 10 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
122483264 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763534 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765840 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
71726944 109181 0 None 1 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 342 2 0 4 3.3 CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 10.1016/j.bmcl.2013.05.062
CHEMBL3039669 109181 0 None 1 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 342 2 0 4 3.3 CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 10.1016/j.bmcl.2013.05.062
CHEMBL3215698 109181 0 None 1 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 342 2 0 4 3.3 CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 10.1016/j.bmcl.2013.05.062
44388796 134838 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 415 5 0 4 4.8 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1 10.1016/j.bmcl.2005.05.059
CHEMBL366516 134838 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 415 5 0 4 4.8 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1 10.1016/j.bmcl.2005.05.059
11131952 56128 0 None -1 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 353 8 1 5 3.4 O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL156385 56128 0 None -1 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 353 8 1 5 3.4 O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O 10.1021/jm020994z
156016142 184527 0 None -5 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 506 8 0 6 5.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4642594 184527 0 None -5 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 506 8 0 6 5.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
155554326 181727 0 None -13 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 457 9 0 6 3.2 COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4565558 181727 0 None -13 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 457 9 0 6 3.2 COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
10638372 181165 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 306 4 0 2 3.0 O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1 10.1021/jm8014553
CHEMBL455210 181165 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 306 4 0 2 3.0 O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1 10.1021/jm8014553
145946265 174293 0 None -1 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 396 10 0 4 3.9 Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4203310 174293 0 None -1 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 396 10 0 4 3.9 Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4299892 174293 0 None -1 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 396 10 0 4 3.9 Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
122483264 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763534 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765840 144870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 334 6 0 3 5.1 O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
155536533 178965 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 444 7 1 5 4.8 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12 10.1016/j.ejmech.2019.111690
CHEMBL4473636 178965 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 444 7 1 5 4.8 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12 10.1016/j.ejmech.2019.111690
155547693 180350 0 None -51 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2019.06.022
CHEMBL4532712 180350 0 None -51 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2019.06.022
90654683 116881 0 None 6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 452 8 1 4 2.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235755 116881 0 None 6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 452 8 1 4 2.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
44437860 98011 0 None -48 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 411 6 0 4 3.2 CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C 10.1016/j.bmc.2007.07.029
CHEMBL240110 98011 0 None -48 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 411 6 0 4 3.2 CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C 10.1016/j.bmc.2007.07.029
53325849 63783 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644269 63783 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
54758201 72767 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 451 6 1 3 5.7 O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
CHEMBL1836782 72767 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 451 6 1 3 5.7 O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
60165413 82135 0 None -31 7 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 378 7 0 4 5.5 O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037531 82135 0 None -31 7 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 378 7 0 4 5.5 O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
168288780 198227 0 None -63 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 8 0 6 3.9 O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5193103 198227 0 None -63 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 8 0 6 3.9 O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
122483226 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3763504 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765871 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
122483226 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3763504 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765871 144884 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 377 5 0 4 3.8 CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
90654703 116866 0 None 26 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 399 7 1 6 1.6 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235740 116866 0 None 26 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 399 7 1 6 1.6 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
134147935 156468 0 None 18 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 487 10 1 6 3.6 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3947670 156468 0 None 18 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 487 10 1 6 3.6 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
154956306 186443 0 None -12 6 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 435 6 0 6 4.5 Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O 10.1016/j.ejmech.2020.112709
CHEMBL4743324 186443 0 None -12 6 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 435 6 0 6 4.5 Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O 10.1016/j.ejmech.2020.112709
90656690 117762 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 325 7 2 4 2.8 OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262418 117762 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 325 7 2 4 2.8 OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
118728522 124495 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 390 8 0 5 3.4 O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401485 124495 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 390 8 0 5 3.4 O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmcl.2015.02.042
164616670 191392 0 None -53 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4849077 191392 0 None -53 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
11726532 103801 0 None -141 4 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 0 5 3.5 COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
CHEMBL26677 103801 0 None -141 4 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 0 5 3.5 COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
44460669 212382 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 283 4 0 3 2.9 C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL81576 212382 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 283 4 0 3 2.9 C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
44460724 212399 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 339 4 0 4 4.0 CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL81684 212399 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 339 4 0 4 4.0 CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1 10.1016/s0960-894x(02)00438-9
168289915 198333 0 None -2 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 553 11 4 8 4.9 Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5194614 198333 0 None -2 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 553 11 4 8 4.9 Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
60195992 88585 2 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 256 2 1 2 2.9 Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
CHEMBL2164333 88585 2 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 256 2 1 2 2.9 Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
10938620 210845 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 416 7 1 3 5.2 COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
CHEMBL70048 210845 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 416 7 1 3 5.2 COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
155538236 179150 0 None -40 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 496 7 1 5 5.2 O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4476164 179150 0 None -40 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 496 7 1 5 5.2 O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
155515920 183463 0 None -109 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4442332 183463 0 None -109 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4598348 183463 0 None -109 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 10.1016/j.ejmech.2019.06.001
46203754 131323 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 nan
CHEMBL3640553 131323 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 nan
10024070 73963 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 402 8 0 4 3.5 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm049743b
CHEMBL187764 73963 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 402 8 0 4 3.5 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm049743b
46203754 131323 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 nan
CHEMBL3640553 131323 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 nan
71458652 88210 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 8 1 5 3.0 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159478 88210 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 8 1 5 3.0 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1 10.1016/j.ejmech.2012.07.043
118731353 124890 0 None 5 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 524 10 1 4 4.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3407516 124890 0 None 5 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 524 10 1 4 4.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
145980458 173496 0 None 1 3 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 476 6 2 5 2.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4282860 173496 0 None 1 3 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 476 6 2 5 2.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O 10.1039/C8MD00168E
155526720 177989 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 437 6 1 3 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1 10.1016/j.bmcl.2019.126703
CHEMBL4459410 177989 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 437 6 1 3 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1 10.1016/j.bmcl.2019.126703
155552707 180827 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 421 6 1 3 5.5 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1 10.1016/j.bmcl.2019.126703
CHEMBL4543789 180827 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 421 6 1 3 5.5 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1 10.1016/j.bmcl.2019.126703
2726 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
621 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
83 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
CHEMBL71 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
DB00477 7706 68 None -13 72 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2013.02.038
54758204 72769 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL1836784 72769 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 395 7 1 3 4.4 CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
11393666 199765 0 None -28 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5201983 199765 0 None -28 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5222597 199765 0 None -28 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
42618267 189602 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL479105 189602 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2009.02.008
11683077 72776 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 414 6 1 2 5.7 O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm200547z
CHEMBL1836791 72776 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 414 6 1 2 5.7 O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm200547z
71061887 99893 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442996 99893 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
71061887 99893 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442996 99893 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
44266284 104119 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 377 5 0 3 5.1 Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL269400 104119 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 377 5 0 3 5.1 Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
22273749 214966 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 363 4 0 3 4.7 COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9840 214966 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 363 4 0 3 4.7 COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1 10.1016/s0960-894x(03)00077-5
135398737 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2020.115578
38 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2020.115578
722 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2020.115578
CHEMBL42 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2020.115578
DB00363 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2020.115578
11191128 91985 0 None 2 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/acs.jmedchem.5b00982
CHEMBL225512 91985 0 None 2 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/acs.jmedchem.5b00982
11191128 91985 0 None 2 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL225512 91985 0 None 2 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
134137732 154547 0 None 11 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 485 11 1 4 5.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3932551 154547 0 None 11 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 485 11 1 4 5.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
179 7188 115 None -9 50 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1016/j.bmcl.2021.128275
2159 7188 115 None -9 50 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1016/j.bmcl.2021.128275
963 7188 115 None -9 50 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1016/j.bmcl.2021.128275
CHEMBL243712 7188 115 None -9 50 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1016/j.bmcl.2021.128275
DB06288 7188 115 None -9 50 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1016/j.bmcl.2021.128275
90656711 117745 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 371 4 2 3 4.4 Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262393 117745 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 371 4 2 3 4.4 Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 10.1016/j.ejmech.2014.04.034
90656711 117745 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 371 4 2 3 4.4 Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262393 117745 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 371 4 2 3 4.4 Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 10.1016/j.ejmech.2014.04.034
118713683 121165 0 None -9 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 409 9 0 6 4.0 COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331386 121165 0 None -9 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 409 9 0 6 4.0 COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
44266245 173996 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 398 5 0 3 4.3 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL429202 173996 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 398 5 0 3 4.3 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(03)00077-5
136180320 124492 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 4 4.1 O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401482 124492 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 4 4.1 O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
164622487 192901 0 None -1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 339 4 0 4 2.8 O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4871850 192901 0 None -1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 339 4 0 4 2.8 O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
2470 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
3300 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
5265 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
99 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL267930 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL5071978 221051 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
145976686 170701 0 None 24 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 564 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4207365 170701 0 None 24 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 564 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
56944861 163853 0 None -42 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 8 2 3 5.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4074195 163853 0 None -42 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 8 2 3 5.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
2470 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
3300 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
5265 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
99 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL267930 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
2470 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2016.06.011
3300 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2016.06.011
5265 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2016.06.011
99 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2016.06.011
CHEMBL267930 10425 50 None -1258 58 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmc.2016.06.011
11207101 82719 1 None - 1 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 236 4 0 4 1.5 COc1ccc2c(c1)N(CCN(C)C)CCO2 10.1021/jm049743b
CHEMBL2051975 82719 1 None - 1 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 236 4 0 4 1.5 COc1ccc2c(c1)N(CCN(C)C)CCO2 10.1021/jm049743b
9818448 134258 1 None -17 3 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 318 4 1 2 4.5 COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1 10.1021/jm049743b
CHEMBL366081 134258 1 None -17 3 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 318 4 1 2 4.5 COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1 10.1021/jm049743b
1353 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
3559 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
86 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
CHEMBL54 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
DB00502 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
198914 153481 8 None 79 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 264 1 3 2 3.1 Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL392401 153481 8 None 79 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 264 1 3 2 3.1 Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
71460455 88141 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 9 1 4 4.6 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159314 88141 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 9 1 4 4.6 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1 10.1016/j.ejmech.2012.07.043
71462156 88146 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 445 6 1 4 5.1 O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
CHEMBL2159319 88146 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 445 6 1 4 5.1 O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
90654673 116871 0 None -54 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 494 10 1 5 3.9 CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235745 116871 0 None -54 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 494 10 1 5 3.9 CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
11154555 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
5037 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
7671 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
CHEMBL2028019 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
CHEMBL3085826 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
DB06016 7587 62 None -117 12 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2019.111736
118736376 125726 0 None -5 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 531 7 0 9 3.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.ejmech.2015.04.046
CHEMBL3423340 125726 0 None -5 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 531 7 0 9 3.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.ejmech.2015.04.046
127052487 147578 0 None -6 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 422 6 2 3 5.1 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3818805 147578 0 None -6 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 422 6 2 3 5.1 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 10.1016/j.bmc.2016.06.011
90656681 117757 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 327 6 0 3 3.5 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262413 117757 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 327 6 0 3 3.5 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2014.04.034
155561995 182501 0 None -36 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 532 7 1 5 5.4 O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4582567 182501 0 None -36 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 532 7 1 5 5.4 O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
155522218 177416 0 None -51 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 492 7 1 5 5.3 O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 10.1016/j.ejmech.2019.01.031
CHEMBL4451231 177416 0 None -51 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 492 7 1 5 5.3 O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 10.1016/j.ejmech.2019.01.031
145983018 172296 0 None -125 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
CHEMBL4240910 172296 0 None -125 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
46204083 131329 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 357 4 1 3 4.4 COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640559 131329 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 357 4 1 3 4.4 COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 nan
46204083 131329 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 357 4 1 3 4.4 COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640559 131329 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 357 4 1 3 4.4 COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 nan
118724648 123243 0 None -5 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 515 7 0 10 1.5 Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3361005 123243 0 None -5 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 515 7 0 10 1.5 Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
127052487 147578 0 None -6 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 422 6 2 3 5.1 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3818805 147578 0 None -6 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 422 6 2 3 5.1 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 10.1016/j.bmc.2016.06.011
49756 211091 13 None -14 8 Rat 6.0 pKi = 6.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm030826m
CHEMBL7143 211091 13 None -14 8 Rat 6.0 pKi = 6.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm030826m
1353 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
3559 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
86 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
CHEMBL54 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
DB00502 8692 93 None -263 85 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmc.2016.06.011
134154108 159399 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 309 4 0 2 4.9 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
CHEMBL3972166 159399 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 309 4 0 2 4.9 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
90654701 116864 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 426 7 1 4 2.8 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235738 116864 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 426 7 1 4 2.8 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
57398619 78341 0 None 7 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1949962 78341 0 None 7 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1963099 78341 0 None 7 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
136180318 124490 0 None -14 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 4 3.7 O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401480 124490 0 None -14 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 4 3.7 O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
46204089 131336 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 nan
CHEMBL3640565 131336 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 nan
46204089 131336 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 nan
CHEMBL3640565 131336 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 nan
44286416 148196 0 None -11 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 448 8 0 6 4.3 O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL38409 148196 0 None -11 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 448 8 0 6 4.3 O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
156014787 184324 0 None 3 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 428 6 1 5 3.6 COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4640281 184324 0 None 3 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 428 6 1 5 3.6 COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
15443 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2021.113243
CHEMBL340211 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2021.113243
15443 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL340211 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
162673483 190551 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 396 8 2 5 2.3 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4796251 190551 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 396 8 2 5 2.3 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803945 190551 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 396 8 2 5 2.3 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
71458622 88133 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 376 7 1 5 3.7 CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159306 88133 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 376 7 1 5 3.7 CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1 10.1016/j.ejmech.2012.07.043
71727068 98042 0 None -2 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL2401934 98042 0 None -2 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL2401938 98042 0 None -2 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
155510928 183248 0 None -575 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 368 4 2 6 2.9 COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
CHEMBL4435010 183248 0 None -575 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 368 4 2 6 2.9 COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
CHEMBL4596543 183248 0 None -575 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 368 4 2 6 2.9 COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
13069623 127387 0 None -50 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 396 6 0 8 1.0 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360994 127387 0 None -50 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 396 6 0 8 1.0 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546108 127387 0 None -50 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 396 6 0 8 1.0 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
44456400 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL1188501 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL2436555 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL536539 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
10317139 73850 0 None -758 2 Rat 4.9 pKi = 4.9 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 371 4 0 5 2.3 COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL187270 73850 0 None -758 2 Rat 4.9 pKi = 4.9 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 371 4 0 5 2.3 COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1 10.1016/j.bmcl.2004.09.029
145973438 171302 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.8b00828
CHEMBL4214853 171302 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.8b00828
145971588 171332 0 None -1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4215182 171332 0 None -1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1 10.1021/acs.jmedchem.8b00828
155539483 179641 0 None -162 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 504 7 2 3 5.4 O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2019.111736
CHEMBL4515160 179641 0 None -162 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 504 7 2 3 5.4 O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2019.111736
44456400 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL1188501 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL2436555 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL536539 19606 0 None -4 10 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
122181336 128656 0 None -8 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 432 6 1 4 3.4 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590088 128656 0 None -8 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 432 6 1 4 3.4 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
118731347 124962 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 10 1 4 3.4 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409031 124962 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 10 1 4 3.4 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
44455426 161928 0 None -1 12 Human 6.9 pKi = 6.9 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL402143 161928 0 None -1 12 Human 6.9 pKi = 6.9 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
72198191 96595 0 None -144 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 5 2 3 4.5 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2013.02.033
CHEMBL2377445 96595 0 None -144 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 5 2 3 4.5 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2013.02.033
46205373 131365 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 nan
CHEMBL3640593 131365 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 nan
46205373 131365 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 nan
CHEMBL3640593 131365 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 nan
122181339 128659 0 None -22 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 500 6 1 4 4.4 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590091 128659 0 None -22 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 500 6 1 4 4.4 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
156013203 184261 0 None -3 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 477 8 0 4 4.7 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2020.115459
CHEMBL4639203 184261 0 None -3 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 477 8 0 4 4.7 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2020.115459
156021656 184966 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4649308 184966 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1 10.1016/j.bmc.2019.115262
162647097 186498 0 None -125 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 465 8 1 6 4.0 COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4744007 186498 0 None -125 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 465 8 1 6 4.0 COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 10.1016/j.ejmech.2020.112149
156020908 184810 0 None -2 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 498 8 0 6 5.4 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4646868 184810 0 None -2 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 498 8 0 6 5.4 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
54758298 72782 0 None -4 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL1836857 72782 0 None -4 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.08.023
11207101 82719 1 None - 1 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 236 4 0 4 1.5 COc1ccc2c(c1)N(CCN(C)C)CCO2 10.1021/jm049743b
CHEMBL2051975 82719 1 None - 1 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 236 4 0 4 1.5 COc1ccc2c(c1)N(CCN(C)C)CCO2 10.1021/jm049743b
44263956 211227 1 None -2 2 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 232 4 0 3 2.3 COc1ccc2c(c1)c(CCN(C)C)cn2C 10.1021/jm049743b
CHEMBL7220 211227 1 None -2 2 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 232 4 0 3 2.3 COc1ccc2c(c1)c(CCN(C)C)cn2C 10.1021/jm049743b
90654700 116863 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 390 8 1 4 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235737 116863 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 390 8 1 4 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
71454899 87935 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 10 1 5 4.3 CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158026 87935 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 10 1 5 4.3 CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1 10.1016/j.ejmech.2012.07.043
155526651 177953 0 None -5 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 464 8 0 4 5.7 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4458938 177953 0 None -5 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 464 8 0 4 5.7 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1 10.1016/j.bmcl.2019.06.029
155540823 179319 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 456 7 0 5 3.6 CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4483779 179319 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 456 7 0 5 3.6 CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2016.06.080
2726 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
621 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
83 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
CHEMBL71 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
DB00477 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
11409589 91905 0 None -1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
CHEMBL224883 91905 0 None -1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
127029649 144950 0 None 5 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 462 6 2 5 2.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3769536 144950 0 None 5 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 462 6 2 5 2.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O 10.1016/j.ejmech.2016.02.024
126720403 169389 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 4 1 5 3.2 CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 10.1016/j.ejmech.2017.12.053
CHEMBL4169236 169389 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 4 1 5 3.2 CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 10.1016/j.ejmech.2017.12.053
155542321 179904 0 None -1096 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 356 5 1 7 2.2 Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2019.06.022
CHEMBL4520796 179904 0 None -1096 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 356 5 1 7 2.2 Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2019.06.022
155542321 179904 0 None -1096 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 356 5 1 7 2.2 Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2022.114645
CHEMBL4520796 179904 0 None -1096 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 356 5 1 7 2.2 Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 10.1016/j.ejmech.2022.114645
90654685 116883 0 None -5 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 522 5 1 4 4.4 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 10.1016/j.ejmech.2014.03.005
CHEMBL3235757 116883 0 None -5 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 522 5 1 4 4.4 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 10.1016/j.ejmech.2014.03.005
162670959 190533 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4791316 190533 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803791 190533 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
90654694 116857 0 None -27 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 402 9 1 5 1.9 COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235731 116857 0 None -27 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 402 9 1 5 1.9 COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
10947658 35475 0 None -10 16 Human 7.9 pKi = 7.9 Binding
Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL137781 35475 0 None -10 16 Human 7.9 pKi = 7.9 Binding
Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
46214153 117472 0 None 3 5 Rat 7.9 pKi = 7.9 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 367 5 1 3 4.0 Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1 10.1021/ml500082j
CHEMBL3260334 117472 0 None 3 5 Rat 7.9 pKi = 7.9 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 367 5 1 3 4.0 Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1 10.1021/ml500082j
44374299 126315 2 None 17 3 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1nc(-c2ccccc2)cs1 10.1016/j.bmcl.2003.11.050
CHEMBL345803 126315 2 None 17 3 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1nc(-c2ccccc2)cs1 10.1016/j.bmcl.2003.11.050
11603514 78265 0 None 1 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 390 11 1 5 4.0 O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926760 78265 0 None 1 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 390 11 1 5 4.0 O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962492 78265 0 None 1 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 390 11 1 5 4.0 O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
127026450 144535 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 8 1 4 4.8 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759281 144535 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 8 1 4 4.8 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1 10.1016/j.ejmech.2015.11.040
145985233 172302 0 None -7 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4241050 172302 0 None -7 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
145984737 172358 0 None -23 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4242392 172358 0 None -23 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
145985527 172488 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4245622 172488 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
145985823 172703 0 None -6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4250475 172703 0 None -6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 6 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 10.1016/j.ejmech.2018.01.002
134153716 159263 0 None 9 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 510 11 1 5 5.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3971125 159263 0 None 9 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 510 11 1 5 5.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
71453252 88136 0 None 15 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 476 8 1 5 4.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159309 88136 0 None 15 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 476 8 1 5 4.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
71453282 88223 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 5 4.5 O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159491 88223 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 5 4.5 O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
71574210 93058 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312934 93058 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
118731351 124966 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409035 124966 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
118731365 124979 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 592 10 0 4 6.4 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409048 124979 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 592 10 0 4 6.4 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
145947977 174494 0 None 48 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 433 6 2 6 1.5 CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4162279 174494 0 None 48 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 433 6 2 6 1.5 CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4302540 174494 0 None 48 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 433 6 2 6 1.5 CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
23642275 7270 31 None 60 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2019.115262
8433 7270 31 None 60 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2019.115262
CHEMBL2164327 7270 31 None 60 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 10.1016/j.bmc.2019.115262
71453252 88136 0 None 15 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 476 8 1 5 4.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1039/C5MD00166H
CHEMBL2159309 88136 0 None 15 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 476 8 1 5 4.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1039/C5MD00166H
142601335 193200 0 None 44 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None 44 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
66803497 165290 0 None -2 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4091193 165290 0 None -2 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
145964944 170860 0 None -14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 391 4 0 4 5.0 Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2017.11.007
CHEMBL4209430 170860 0 None -14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 391 4 0 4 5.0 Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2017.11.007
10862787 109814 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 423 6 1 3 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 10.1016/j.bmc.2019.06.028
CHEMBL307101 109814 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 423 6 1 3 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 10.1016/j.bmc.2019.06.028
90656696 117775 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 367 9 1 4 4.2 CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262430 117775 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 367 9 1 4 4.2 CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
44374299 126315 2 None 17 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1nc(-c2ccccc2)cs1 10.1016/j.bmc.2010.01.035
CHEMBL345803 126315 2 None 17 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1nc(-c2ccccc2)cs1 10.1016/j.bmc.2010.01.035
127051844 147625 0 None 1 9 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 322 6 1 3 2.8 NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819427 147625 0 None 1 9 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 322 6 1 3 2.8 NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
145988193 173858 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4289605 173858 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
90656672 117769 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 451 8 1 5 3.8 O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262425 117769 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 451 8 1 5 3.8 O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
155565215 182389 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 433 6 1 7 3.5 Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O 10.1016/j.ejmech.2019.111690
CHEMBL4580230 182389 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 433 6 1 7 3.5 Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O 10.1016/j.ejmech.2019.111690
10862787 109814 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 423 6 1 3 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 10.1021/jm0104264
CHEMBL307101 109814 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 423 6 1 3 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 10.1021/jm0104264
11826723 211022 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 464 6 1 2 5.9 O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0104264
CHEMBL71057 211022 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 464 6 1 2 5.9 O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0104264
142601335 193200 0 None 44 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4876193 193200 0 None 44 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
127051844 147625 0 None 1 9 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 322 6 1 3 2.8 NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819427 147625 0 None 1 9 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 322 6 1 3 2.8 NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
72734860 110734 0 None -6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 251 1 2 1 1.7 NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3092753 110734 0 None -6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 251 1 2 1 1.7 NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2 10.1016/j.bmc.2013.10.010
44456395 102446 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 225 1 2 4 2.0 COc1c(Cl)ccc2c1C(C)NC(N)=N2 10.1016/j.bmcl.2007.10.080
CHEMBL258073 102446 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 225 1 2 4 2.0 COc1c(Cl)ccc2c1C(C)NC(N)=N2 10.1016/j.bmcl.2007.10.080
11302161 74052 0 None -8 2 Rat 7.9 pKi = 7.9 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 337 7 0 2 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1 10.1021/jm0498102
CHEMBL188176 74052 0 None -8 2 Rat 7.9 pKi = 7.9 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 337 7 0 2 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1 10.1021/jm0498102
44319240 113687 0 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 374 6 1 2 4.8 O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL314672 113687 0 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 374 6 1 2 4.8 O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
135398737 7745 93 None -7 90 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/s0960-894x(00)00166-9
38 7745 93 None -7 90 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/s0960-894x(00)00166-9
722 7745 93 None -7 90 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/s0960-894x(00)00166-9
CHEMBL42 7745 93 None -7 90 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/s0960-894x(00)00166-9
DB00363 7745 93 None -7 90 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/s0960-894x(00)00166-9
6540428 191643 1 None -7 3 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/s0960-894x(00)00166-9
CHEMBL3989558 191643 1 None -7 3 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/s0960-894x(00)00166-9
CHEMBL485253 191643 1 None -7 3 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/s0960-894x(00)00166-9
10571274 106235 0 None 42 3 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 371 3 0 3 5.1 COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
CHEMBL283065 106235 0 None 42 3 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 371 3 0 3 5.1 COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
135398737 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030841r
38 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030841r
722 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030841r
CHEMBL42 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030841r
DB00363 7745 93 None -13 90 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030841r
6540428 191643 1 None -19 3 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1021/jm030841r
CHEMBL3989558 191643 1 None -19 3 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1021/jm030841r
CHEMBL485253 191643 1 None -19 3 Human 7.9 pKi = 7.9 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1021/jm030841r
11151958 73745 0 None -9 3 Rat 7.9 pKi = 7.9 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1 10.1021/jm0498102
CHEMBL186758 73745 0 None -9 3 Rat 7.9 pKi = 7.9 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1 10.1021/jm0498102
71062123 99892 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442995 99892 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmc.2014.01.016
71062123 99892 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442995 99892 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
76284453 111783 0 None 67 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 476 10 1 5 4.0 Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1 10.1016/j.bmc.2014.01.016
CHEMBL3113595 111783 0 None 67 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 476 10 1 5 4.0 Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1 10.1016/j.bmc.2014.01.016
90656713 117746 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 385 4 2 3 4.7 Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.04.034
CHEMBL3262394 117746 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 385 4 2 3 4.7 Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.04.034
162662399 188708 0 None -12 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 399 7 1 5 3.1 Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1 10.1016/j.ejmech.2020.112149
CHEMBL4779739 188708 0 None -12 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 399 7 1 5 3.1 Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1 10.1016/j.ejmech.2020.112149
11948707 172946 0 None -158 13 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 373 7 0 8 0.6 COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 10.1021/acs.jmedchem.2c00633
CHEMBL426317 172946 0 None -158 13 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 373 7 0 8 0.6 COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 10.1021/acs.jmedchem.2c00633
21830793 98610 10 None -85 46 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 10.1016/j.bmc.2013.05.050
CHEMBL2413154 98610 10 None -85 46 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 10.1016/j.bmc.2013.05.050
118728524 124497 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 5 4.0 O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401487 124497 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 5 4.0 O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2015.02.042
145990586 173622 0 None -9 11 Human 6.9 pKi = 6.9 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
CHEMBL4285281 173622 0 None -9 11 Human 6.9 pKi = 6.9 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
66801425 163965 0 None -39 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 441 8 2 3 4.5 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4075673 163965 0 None -39 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 441 8 2 3 4.5 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
66801354 118860 0 None -1 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 450 7 1 6 3.5 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
CHEMBL3289977 118860 0 None -1 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 450 7 1 6 3.5 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 10.1021/jm401895u
44437329 158379 0 None -8 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 692 18 0 8 7.1 COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396349 158379 0 None -8 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 692 18 0 8 7.1 COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
46205700 131171 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3639394 131171 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1ccc(-c2ccccc2C2CCNC2)cc1 nan
46204088 131335 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 255 4 1 3 2.7 COc1ccc(-c2ccccc2)cc1OC1CNC1 nan
CHEMBL3640564 131335 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 255 4 1 3 2.7 COc1ccc(-c2ccccc2)cc1OC1CNC1 nan
46205697 131370 2 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 223 2 1 1 3.4 c1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3640598 131370 2 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 223 2 1 1 3.4 c1ccc(-c2ccccc2C2CCNC2)cc1 nan
46206344 131385 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 2 1 1 4.7 Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C nan
CHEMBL3640612 131385 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 2 1 1 4.7 Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C nan
46205700 131171 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3639394 131171 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1ccc(-c2ccccc2C2CCNC2)cc1 nan
46204088 131335 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 255 4 1 3 2.7 COc1ccc(-c2ccccc2)cc1OC1CNC1 nan
CHEMBL3640564 131335 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 255 4 1 3 2.7 COc1ccc(-c2ccccc2)cc1OC1CNC1 nan
46205697 131370 2 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 223 2 1 1 3.4 c1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3640598 131370 2 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 223 2 1 1 3.4 c1ccc(-c2ccccc2C2CCNC2)cc1 nan
46206344 131385 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 2 1 1 4.7 Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C nan
CHEMBL3640612 131385 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 2 1 1 4.7 Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C nan
162662361 188251 0 None -20 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 465 8 1 6 4.0 COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4764557 188251 0 None -20 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 465 8 1 6 4.0 COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 10.1016/j.ejmech.2020.112149
2726 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
621 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
83 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
CHEMBL71 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
DB00477 7706 68 None -13 72 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2013.12.024
15443 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2021.113243
CHEMBL340211 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2021.113243
15443 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL340211 124588 96 None -17 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
44374206 59331 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 248 5 1 4 2.1 CN(C)CCSc1n[nH]c(-c2ccccc2)n1 10.1016/j.bmcl.2003.11.050
CHEMBL159223 59331 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 248 5 1 4 2.1 CN(C)CCSc1n[nH]c(-c2ccccc2)n1 10.1016/j.bmcl.2003.11.050
60364 113171 10 None -19 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 264 4 0 2 3.7 CN(C)CCc1cn(-c2ccccc2)c2ccccc12 10.1016/j.ejmech.2014.01.055
CHEMBL3121413 113171 10 None -19 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 264 4 0 2 3.7 CN(C)CCc1cn(-c2ccccc2)c2ccccc12 10.1016/j.ejmech.2014.01.055
CHEMBL3139439 113171 10 None -19 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 264 4 0 2 3.7 CN(C)CCc1cn(-c2ccccc2)c2ccccc12 10.1016/j.ejmech.2014.01.055
21557475 181668 0 None -6 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 442 8 0 5 4.2 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4564093 181668 0 None -6 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 442 8 0 5 4.2 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
71602639 96456 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376449 96456 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
23661735 97763 0 None -467 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 423 3 0 4 3.7 O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2007.07.029
CHEMBL239681 97763 0 None -467 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 423 3 0 4 3.7 O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2007.07.029
145946271 174296 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 495 7 2 6 2.5 N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4162548 174296 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 495 7 2 6 2.5 N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4299919 174296 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 495 7 2 6 2.5 N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
145965840 170795 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 425 5 1 4 3.8 O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4208468 170795 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 425 5 1 4 3.8 O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
71449642 88208 0 None -1 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 7 1 5 2.8 O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159476 88208 0 None -1 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 7 1 5 2.8 O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
90654842 119421 0 None -2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1 10.1016/j.ejmech.2014.01.065
CHEMBL3233670 119421 0 None -2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1 10.1016/j.ejmech.2014.01.065
CHEMBL3302936 119421 0 None -2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1 10.1016/j.ejmech.2014.01.065
118736374 125724 0 None -13 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 559 8 0 9 4.0 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423338 125724 0 None -13 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 559 8 0 9 4.0 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
11328878 143708 0 None 2 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 469 9 1 4 5.2 COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL374261 143708 0 None 2 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 469 9 1 4 5.2 COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
136118614 99839 0 None -13 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 318 1 3 2 2.3 CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O 10.1016/j.bmc.2013.09.011
CHEMBL2442276 99839 0 None -13 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 318 1 3 2 2.3 CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O 10.1016/j.bmc.2013.09.011
2843443 124710 18 None 1 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 380 2 0 2 5.3 Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1 10.1016/j.bmcl.2015.03.049
CHEMBL3403336 124710 18 None 1 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 380 2 0 2 5.3 Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1 10.1016/j.bmcl.2015.03.049
56850924 78297 0 None -22 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 348 8 1 5 2.8 O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926758 78297 0 None -22 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 348 8 1 5 2.8 O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962806 78297 0 None -22 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 348 8 1 5 2.8 O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
90654850 119423 0 None 2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 502 9 0 4 4.6 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233674 119423 0 None 2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 502 9 0 4 4.6 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3302943 119423 0 None 2 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 502 9 0 4 4.6 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
156015194 184332 0 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 377 4 2 4 3.0 C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4640332 184332 0 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 377 4 2 4 3.0 C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
10313351 17035 23 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 177 1 1 2 1.5 COc1cccc2c1C[C@H](N)CC2 10.1021/jm030826m
CHEMBL1161324 17035 23 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 177 1 1 2 1.5 COc1cccc2c1C[C@H](N)CC2 10.1021/jm030826m
42618253 188086 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 5 0 5 3.6 O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1 10.1016/j.bmcl.2009.02.008
CHEMBL476248 188086 0 None -2 2 Human 5.9 pKi = 5.9 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 5 0 5 3.6 O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1 10.1016/j.bmcl.2009.02.008
135367869 171513 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4217548 171513 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
9419 42696 35 None -616 6 Human 4.9 pKi = 4.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 295 3 0 3 3.0 CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21 10.1016/j.bmcl.2020.127493
CHEMBL1442422 42696 35 None -616 6 Human 4.9 pKi = 4.9 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 295 3 0 3 3.0 CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21 10.1016/j.bmcl.2020.127493
126720440 169805 0 None -2041 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 339 4 1 5 2.6 CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 10.1016/j.ejmech.2017.12.053
CHEMBL4175829 169805 0 None -2041 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 339 4 1 5 2.6 CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 10.1016/j.ejmech.2017.12.053
71574300 93061 0 None -5 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312937 93061 0 None -5 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1 10.1016/j.ejmech.2012.11.042
155554325 183300 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4548353 183300 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4597000 183300 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
118736367 125717 0 None -10 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 479 7 1 10 1.7 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2015.04.046
CHEMBL3423331 125717 0 None -10 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 479 7 1 10 1.7 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2015.04.046
15599151 180718 0 None -1621 5 Human 5.9 pKi = 5.9 Binding
Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)
ChEMBL 379 4 3 8 1.3 O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O 10.1021/acs.jmedchem.8b01662
CHEMBL4541086 180718 0 None -1621 5 Human 5.9 pKi = 5.9 Binding
Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)
ChEMBL 379 4 3 8 1.3 O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O 10.1021/acs.jmedchem.8b01662
135367869 171513 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4217548 171513 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
164614828 192048 0 None -186 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4858771 192048 0 None -186 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
44268087 26966 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
CHEMBL13049 26966 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
44460641 112627 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 271 3 0 3 2.6 Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL312720 112627 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 271 3 0 3 2.6 Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
53370045 173212 7 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 376 6 2 6 0.5 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1 10.1039/C8MD00168E
CHEMBL4277406 173212 7 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 376 6 2 6 0.5 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1 10.1039/C8MD00168E
164614734 192175 0 None -41 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 443 8 0 6 2.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4860754 192175 0 None -41 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 443 8 0 6 2.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
155546595 180322 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 586 10 1 6 5.8 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4531761 180322 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 586 10 1 6 5.8 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
44424662 92555 0 None -8 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 488 9 0 9 2.5 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229366 92555 0 None -8 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 488 9 0 9 2.5 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
11421024 91469 0 None 30 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 446 8 1 5 4.7 O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL222603 91469 0 None 30 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 446 8 1 5 4.7 O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
1346 6871 117 None -147 9 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm030826m
280 6871 117 None -147 9 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm030826m
9899402 6871 117 None -147 9 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm030826m
CHEMBL9666 6871 117 None -147 9 Rat 6.9 pKi = 6.9 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm030826m
49850772 63173 0 None -794 9 Human 6.9 pKi = 6.9 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 397 5 0 5 4.1 Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1631545 63173 0 None -794 9 Human 6.9 pKi = 6.9 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 397 5 0 5 4.1 Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 10.1021/jm100714c
10619437 23344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
CHEMBL12389 23344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
10619437 23344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
CHEMBL12389 23344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
44368683 52325 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
CHEMBL152873 52325 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
134156222 161130 0 None -1 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 334 5 1 3 3.2 O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 10.1016/j.bmc.2016.09.019
CHEMBL3986927 161130 0 None -1 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 334 5 1 3 3.2 O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 10.1016/j.bmc.2016.09.019
CHEMBL5073337 221071 0 None -30 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
CHEMBL5093017 222180 0 None -35 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2ccc(F)c(Cl)c2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
162657622 187916 0 None -48 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 469 7 1 5 4.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4760655 187916 0 None -48 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 469 7 1 5 4.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1 10.1016/j.ejmech.2020.112149
277 8083 62 None -63 50 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/j.ejmech.2019.111705
2913 8083 62 None -63 50 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/j.ejmech.2019.111705
765 8083 62 None -63 50 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/j.ejmech.2019.111705
CHEMBL516 8083 62 None -63 50 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/j.ejmech.2019.111705
DB00434 8083 62 None -63 50 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/j.ejmech.2019.111705
11248705 97070 0 None -50 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL238519 97070 0 None -50 10 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
11178830 154905 0 None -79 9 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL393539 154905 0 None -79 9 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
122483276 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763677 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765878 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
60167451 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL2037520 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
145971527 169896 0 None -7 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 337 7 1 2 5.6 Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL4177293 169896 0 None -7 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 337 7 1 2 5.6 Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1 10.1016/j.ejmech.2018.04.010
57393878 75207 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 4 3.8 O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
CHEMBL1917353 75207 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 4 3.8 O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
164610188 191834 0 None -194 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4855393 191834 0 None -194 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
1574 6869 60 None -13 21 Human 5.9 pKi = 5.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 10.1021/jm030030n
218 6869 60 None -13 21 Human 5.9 pKi = 5.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 10.1021/jm030030n
CHEMBL266591 6869 60 None -13 21 Human 5.9 pKi = 5.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 10.1021/jm030030n
11191906 18539 0 None -25 12 Human 5.9 pKi = 5.9 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 537 12 1 3 7.3 O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 10.1016/j.bmcl.2005.06.024
CHEMBL1181665 18539 0 None -25 12 Human 5.9 pKi = 5.9 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 537 12 1 3 7.3 O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 10.1016/j.bmcl.2005.06.024
CHEMBL187928 18539 0 None -25 12 Human 5.9 pKi = 5.9 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 537 12 1 3 7.3 O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 10.1016/j.bmcl.2005.06.024
71602639 96456 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376449 96456 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
155519891 177172 0 None -5 6 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 249 2 1 4 1.9 COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21 10.1021/acsmedchemlett.9b00225
CHEMBL4447975 177172 0 None -5 6 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 249 2 1 4 1.9 COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21 10.1021/acsmedchemlett.9b00225
153287568 177764 0 None -15 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 217 0 1 2 2.5 Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21 10.1021/acsmedchemlett.9b00225
CHEMBL4456195 177764 0 None -15 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 217 0 1 2 2.5 Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21 10.1021/acsmedchemlett.9b00225
1524 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
197 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
3822 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
88 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
CHEMBL51 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
DB12465 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1016/j.ejmech.2019.111705
52952420 69365 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 377 5 1 5 4.0 N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782808 69365 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 377 5 1 5 4.0 N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
17374371 124704 9 None -2 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 447 5 1 5 4.7 O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1 10.1016/j.bmcl.2015.03.049
CHEMBL3403330 124704 9 None -2 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 447 5 1 5 4.7 O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1 10.1016/j.bmcl.2015.03.049
57399868 78331 0 None 39 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949978 78331 0 None 39 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963032 78331 0 None 39 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
134140472 152799 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 241 4 0 2 3.4 COc1ccccc1-c1cccc(CN(C)C)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3918663 152799 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 241 4 0 2 3.4 COc1ccccc1-c1cccc(CN(C)C)c1 10.1016/j.ejmech.2016.07.029
49756 211091 13 None -5 8 Human 5.9 pKi = 5.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm030030n
CHEMBL7143 211091 13 None -5 8 Human 5.9 pKi = 5.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm030030n
46204731 131348 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 318 3 1 3 3.6 N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640577 131348 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 318 3 1 3 3.6 N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
46204731 131348 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 318 3 1 3 3.6 N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640577 131348 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 318 3 1 3 3.6 N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
134156222 161130 0 None -1 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 334 5 1 3 3.2 O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 10.1016/j.bmc.2016.09.019
CHEMBL3986927 161130 0 None -1 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 334 5 1 3 3.2 O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 10.1016/j.bmc.2016.09.019
122483276 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763677 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765878 144891 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 439 8 0 4 5.8 O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
60167451 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037520 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
60167451 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL2037520 82123 0 None -1 7 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 468 7 1 6 5.3 O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
22425072 124718 7 None -1 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 457 5 0 4 6.5 Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403343 124718 7 None -1 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 457 5 0 4 6.5 Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.03.049
122442272 145126 0 None -40 15 Human 5.9 pKi = 5.9 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3769968 145126 0 None -40 15 Human 5.9 pKi = 5.9 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3771384 145126 0 None -40 15 Human 5.9 pKi = 5.9 Binding
Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
137646281 164585 0 None -295 17 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 423 8 0 7 3.8 COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 10.1021/acs.jmedchem.9b00412
CHEMBL4083252 164585 0 None -295 17 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 423 8 0 7 3.8 COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 10.1021/acs.jmedchem.9b00412
46233350 207079 0 None 7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 286 5 0 3 4.0 Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1 10.1016/j.bmc.2010.01.035
CHEMBL597357 207079 0 None 7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 286 5 0 3 4.0 Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1 10.1016/j.bmc.2010.01.035
4723431 178202 14 None -14 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 316 6 2 2 4.8 c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4462814 178202 14 None -14 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 316 6 2 2 4.8 c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1 10.1016/j.ejmech.2019.111857
122483231 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765208 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765835 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
122483231 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765208 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765835 144865 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 336 8 0 3 5.3 CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
11443608 150508 0 None 1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
CHEMBL390062 150508 0 None 1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
46205695 131368 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 253 3 1 2 3.4 COc1ccc(-c2ccccc2)cc1C1CCNC1 nan
CHEMBL3640596 131368 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 253 3 1 2 3.4 COc1ccc(-c2ccccc2)cc1C1CCNC1 nan
46206025 131383 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 291 2 1 1 4.7 Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1 nan
CHEMBL3640610 131383 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 291 2 1 1 4.7 Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1 nan
46205695 131368 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 253 3 1 2 3.4 COc1ccc(-c2ccccc2)cc1C1CCNC1 nan
CHEMBL3640596 131368 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 253 3 1 2 3.4 COc1ccc(-c2ccccc2)cc1C1CCNC1 nan
46206025 131383 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 291 2 1 1 4.7 Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1 nan
CHEMBL3640610 131383 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 291 2 1 1 4.7 Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1 nan
44393021 71824 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182356 71824 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
154926540 197103 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant
ChEMBL 439 10 1 4 4.6 CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21 10.1021/acs.jmedchem.2c00633
CHEMBL5176380 197103 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant
ChEMBL 439 10 1 4 4.6 CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21 10.1021/acs.jmedchem.2c00633
54764323 75213 0 None 85 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 429 8 0 4 4.5 CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
CHEMBL1917359 75213 0 None 85 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 429 8 0 4 4.5 CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
127040908 143851 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 8 0 4 4.1 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747071 143851 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 8 0 4 4.1 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
71449641 88189 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 468 9 1 4 4.6 O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159458 88189 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 468 9 1 4 4.6 O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
60196073 88590 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 283 3 1 4 2.7 O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
CHEMBL2164339 88590 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 283 3 1 4 2.7 O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
10571274 106235 0 None 42 3 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 371 3 0 3 5.1 COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
CHEMBL283065 106235 0 None 42 3 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 371 3 0 3 5.1 COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
44408816 83353 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 397 8 0 3 5.0 O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL206305 83353 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 397 8 0 3 5.0 O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
54758392 72779 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 398 6 1 2 5.5 O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1 10.1021/jm200547z
CHEMBL1836794 72779 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 398 6 1 2 5.5 O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1 10.1021/jm200547z
66801000 118839 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 472 7 1 7 4.0 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3289957 118839 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 472 7 1 7 4.0 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
56944473 118905 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 488 8 1 7 4.5 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3290021 118905 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 488 8 1 7 4.5 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
9839050 119156 0 None -26 9 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 293 2 0 2 3.8 CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 10.1021/jm049632c
CHEMBL329566 119156 0 None -26 9 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 293 2 0 2 3.8 CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 10.1021/jm049632c
162664534 188881 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 418 9 0 6 4.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4781863 188881 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 418 9 0 6 4.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
90656691 117765 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 323 7 1 4 3.1 O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262421 117765 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 323 7 1 4 3.1 O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
135458394 104467 5 None -2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 243 0 2 3 2.9 CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1 10.1016/j.bmcl.2007.10.080
CHEMBL271298 104467 5 None -2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 243 0 2 3 2.9 CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1 10.1016/j.bmcl.2007.10.080
11173572 136685 0 None -1 2 Rat 7.9 pKi = 7.9 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 281 2 0 2 3.8 Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmcl.2004.11.013
CHEMBL367584 136685 0 None -1 2 Rat 7.9 pKi = 7.9 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 281 2 0 2 3.8 Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmcl.2004.11.013
10706626 105909 0 None 1 6 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N 10.1021/jm030030n
CHEMBL281048 105909 0 None 1 6 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N 10.1021/jm030030n
10706626 105909 0 None -1 6 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N 10.1021/jm9911433
CHEMBL281048 105909 0 None -1 6 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N 10.1021/jm9911433
11173572 136685 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 281 2 0 2 3.8 Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmc.2010.01.035
CHEMBL367584 136685 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 281 2 0 2 3.8 Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmc.2010.01.035
46203760 131327 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
CHEMBL3640557 131327 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
46203760 131327 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
CHEMBL3640557 131327 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
10730269 103878 0 None 1 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 263 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O 10.1021/jm9911433
CHEMBL26751 103878 0 None 1 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 263 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O 10.1021/jm9911433
135895192 178990 0 None 85 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 418 6 1 5 4.3 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4473885 178990 0 None 85 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 418 6 1 5 4.3 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
122181341 128661 0 None -42 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 490 8 1 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590093 128661 0 None -42 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 490 8 1 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1 10.1016/j.bmc.2015.04.026
162672061 190542 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4793191 190542 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803857 190542 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 7 1 4 4.5 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
44424654 92529 0 None 1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 460 7 0 9 1.7 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229123 92529 0 None 1 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 460 7 0 9 1.7 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
9867475 24785 0 None -426 9 Human 5.9 pKi = 5.9 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 432 7 0 5 4.2 CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL126340 24785 0 None -426 9 Human 5.9 pKi = 5.9 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 432 7 0 5 4.2 CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 10.1021/jm010943m
2870750 124708 7 None -2 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 442 4 1 5 6.0 Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12 10.1016/j.bmcl.2015.03.049
CHEMBL3403334 124708 7 None -2 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 442 4 1 5 6.0 Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12 10.1016/j.bmcl.2015.03.049
122483238 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763567 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765853 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
24768524 99977 0 None -4 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 8 1 3 4.7 O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL244577 99977 0 None -4 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 8 1 3 4.7 O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
13069627 127391 0 None -26 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 444 7 0 8 2.1 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3361001 127391 0 None -26 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 444 7 0 8 2.1 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546113 127391 0 None -26 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 444 7 0 8 2.1 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
134136246 149316 0 None -1 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 275 3 0 1 4.1 C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 10.1016/j.bmc.2016.09.019
CHEMBL3890841 149316 0 None -1 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 275 3 0 1 4.1 C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 10.1016/j.bmc.2016.09.019
162663078 188773 0 None -46 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 489 7 1 6 5.0 Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 10.1016/j.ejmech.2020.112149
CHEMBL4780470 188773 0 None -46 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 489 7 1 6 5.0 Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 10.1016/j.ejmech.2020.112149
134130594 149022 0 None -7 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 8 0 5 4.6 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884728 149022 0 None -7 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 8 0 5 4.6 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2016.12.039
16763549 124719 9 None -4 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 342 5 1 5 2.8 COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N 10.1016/j.bmcl.2015.03.049
CHEMBL3403344 124719 9 None -4 4 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 342 5 1 5 2.8 COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N 10.1016/j.bmcl.2015.03.049
90654697 116860 0 None -5 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 406 8 1 4 2.5 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235734 116860 0 None -5 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 406 8 1 4 2.5 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2014.03.005
122483238 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763567 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765853 144882 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 6 0 4 4.3 O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
57397410 75197 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1 10.1016/j.bmc.2011.09.044
CHEMBL1917343 75197 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1 10.1016/j.bmc.2011.09.044
134136246 149316 0 None -1 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 275 3 0 1 4.1 C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 10.1016/j.bmc.2016.09.019
CHEMBL3890841 149316 0 None -1 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 275 3 0 1 4.1 C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 10.1016/j.bmc.2016.09.019
156010584 183858 0 None -17 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 335 2 1 4 4.4 CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4633042 183858 0 None -17 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 335 2 1 4 4.4 CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
56649648 74630 0 None -398 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 474 8 0 5 3.0 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910139 74630 0 None -398 8 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 474 8 0 5 3.0 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
10780842 104680 0 None -1 5 Rat 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 304 1 1 2 3.0 CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL27247 104680 0 None -1 5 Rat 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 304 1 1 2 3.0 CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
134131151 149014 0 None -1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 416 9 0 5 3.9 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884634 149014 0 None -1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 416 9 0 5 3.9 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmc.2016.12.039
155538877 179572 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 382 7 1 5 3.1 O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
CHEMBL4513482 179572 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 382 7 1 5 3.1 O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
1524 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
197 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
3822 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
88 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
CHEMBL51 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
DB12465 8962 96 None -501 51 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1021/jm030030n
164618028 192122 0 None -9 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 352 7 1 4 3.2 CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4859988 192122 0 None -9 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 352 7 1 4 3.2 CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
42618270 97973 0 None -22 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 435 6 0 4 3.8 O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
CHEMBL239897 97973 0 None -22 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 435 6 0 4 3.8 O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
164618028 192122 0 None -9 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 352 7 1 4 3.2 CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4859988 192122 0 None -9 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 352 7 1 4 3.2 CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
162671033 190534 0 None -4 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4793296 190534 0 None -4 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4803797 190534 0 None -4 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
145985958 172389 0 None -112 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
CHEMBL4243036 172389 0 None -112 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
18137017 170307 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4202769 170307 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
164624246 192722 0 None -158 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4869411 192722 0 None -158 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
10042333 170253 1 None -831 3 Human 5.9 pKi = 5.9 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 331 5 1 2 4.0 OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 10.1021/jm0200411
CHEMBL420010 170253 1 None -831 3 Human 5.9 pKi = 5.9 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 331 5 1 2 4.0 OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 10.1021/jm0200411
118731355 124969 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 10 0 5 3.7 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409038 124969 0 None -7 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 10 0 5 3.7 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1 10.1016/j.ejmech.2014.12.041
90654844 119401 0 None -1 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233671 119401 0 None -1 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3302598 119401 0 None -1 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2014.01.065
71727067 98041 0 None -8 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 414 5 0 5 4.3 COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL2401937 98041 0 None -8 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 414 5 0 5 4.3 COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL3217036 98041 0 None -8 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 414 5 0 5 4.3 COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
155524491 177735 0 None -169 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 530 7 1 5 5.8 O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4455658 177735 0 None -169 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 530 7 1 5 5.8 O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
71458648 88190 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 8 1 4 3.0 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159459 88190 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 8 1 4 3.0 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
118736364 125714 0 None -676 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 451 6 1 10 1.0 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423328 125714 0 None -676 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 451 6 1 10 1.0 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
90656706 119387 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 443 11 1 4 5.8 Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262436 119387 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 443 11 1 4 5.8 Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3302236 119387 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 443 11 1 4 5.8 Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1 10.1016/j.ejmech.2014.04.034
155516118 176818 3 None -549 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 351 6 3 4 4.0 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4442855 176818 3 None -549 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 351 6 3 4 4.0 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
134131015 149083 0 None -15 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 9 0 5 5.2 Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1 10.1016/j.bmc.2016.12.039
CHEMBL3885282 149083 0 None -15 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 9 0 5 5.2 Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1 10.1016/j.bmc.2016.12.039
155569396 182917 0 None 10 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 279 2 1 2 4.1 CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4592256 182917 0 None 10 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 279 2 1 2 4.1 CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12 10.1016/j.ejmech.2019.03.017
134144304 161272 0 None -2 9 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3952251 161272 0 None -2 9 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3990525 161272 0 None -2 9 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
168281650 197981 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 467 6 0 7 3.9 COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5189417 197981 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 467 6 0 7 3.9 COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
155533850 178671 0 None -45 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 530 7 1 5 5.8 O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4469633 178671 0 None -45 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 530 7 1 5 5.8 O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
44460701 212044 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 302 4 0 5 2.2 CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL78977 212044 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 302 4 0 5 2.2 CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1 10.1016/s0960-894x(02)00438-9
54758294 72772 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL1836787 72772 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
44424667 92498 0 None -3 2 Rat 4.9 pKi = 4.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 398 5 1 8 -0.1 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
CHEMBL228938 92498 0 None -3 2 Rat 4.9 pKi = 4.9 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 398 5 1 8 -0.1 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
122483254 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764307 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765844 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
10472143 126055 0 None -31 16 Human 7.9 pKi = 7.9 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL343755 126055 0 None -31 16 Human 7.9 pKi = 7.9 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
53324535 63781 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 323 3 1 3 3.9 Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644267 63781 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 323 3 1 3 3.9 Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
242 7258 124 None -15 51 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm030030n
34 7258 124 None -15 51 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm030030n
60795 7258 124 None -15 51 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm030030n
CHEMBL1112 7258 124 None -15 51 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm030030n
DB01238 7258 124 None -15 51 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm030030n
44461070 212416 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 363 4 0 3 3.8 CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL81784 212416 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 363 4 0 3 3.8 CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
137642134 165120 0 None 10 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4089427 165120 0 None 10 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
127028473 145051 0 None 22 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 451 6 2 6 1.6 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770639 145051 0 None 22 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 451 6 2 6 1.6 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2016.02.024
127026451 144541 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 8 1 4 4.8 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
CHEMBL3759342 144541 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 8 1 4 4.8 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
127026752 144573 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 8 1 4 3.0 CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1 10.1016/j.ejmech.2015.11.040
CHEMBL3759577 144573 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 8 1 4 3.0 CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1 10.1016/j.ejmech.2015.11.040
127026133 144599 0 None 6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 8 1 4 5.4 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759819 144599 0 None 6 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 8 1 4 5.4 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
145983128 172604 0 None -2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4248597 172604 0 None -2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
134155645 157852 0 None 7 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.7 C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL3958956 157852 0 None 7 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.7 C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
71458650 88206 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 7 1 5 4.1 O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159474 88206 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 7 1 5 4.1 O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
155566925 182643 0 None 56 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 293 1 1 2 3.5 Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4585956 182643 0 None 56 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 293 1 1 2 3.5 Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12 10.1016/j.ejmech.2019.03.017
66801295 163920 0 None -8 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 447 7 2 3 4.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4075144 163920 0 None -8 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 447 7 2 3 4.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
164621610 192970 0 None 2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4872800 192970 0 None 2 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
118706282 127308 0 None -17 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
CHEMBL3310111 127308 0 None -17 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
CHEMBL3545465 127308 0 None -17 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
66801246 118903 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 471 8 1 7 3.6 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
CHEMBL3290019 118903 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 471 8 1 7 3.6 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
118713681 121163 0 None -3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 379 8 0 5 4.0 O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331384 121163 0 None -3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 379 8 0 5 4.0 O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
44266203 105183 0 None 19 2 Human 7.9 pKi = 7.9 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 389 4 0 5 3.2 O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL275475 105183 0 None 19 2 Human 7.9 pKi = 7.9 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 389 4 0 5 3.2 O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
164621610 192970 0 None 2 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4872800 192970 0 None 2 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
134157769 160838 0 None 10 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 531 14 2 6 4.7 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3984541 160838 0 None 10 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 531 14 2 6 4.7 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
162676611 190253 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 501 9 1 6 5.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4799274 190253 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 501 9 1 6 5.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1 10.1016/j.ejmech.2020.112395
164614709 191988 0 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 6 0 4 4.1 O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4857665 191988 0 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 6 0 4 4.1 O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
69729 176452 73 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 180 4 0 1 3.2 CCCCC(=O)c1ccc(F)cc1 10.1021/jm030030n
CHEMBL443757 176452 73 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 180 4 0 1 3.2 CCCCC(=O)c1ccc(F)cc1 10.1021/jm030030n
45272891 202694 0 None 72 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 459 9 3 5 2.4 COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2009.06.038
CHEMBL559260 202694 0 None 72 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 459 9 3 5 2.4 COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2009.06.038
44460642 212526 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 281 3 0 3 2.3 C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL82708 212526 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 281 3 0 3 2.3 C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
24873261 189973 0 None -2 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 241 2 1 3 2.3 CCn1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4795756 189973 0 None -2 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 241 2 1 3 2.3 CCn1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
56944860 165786 0 None -61 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 8 2 3 5.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
CHEMBL4096479 165786 0 None -61 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 8 2 3 5.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
155520553 183288 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4449590 183288 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4596888 183288 0 None 1 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
599482 209763 9 None -10 5 Human 5.9 pKi = 5.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.09.027
CHEMBL6310 209763 9 None -10 5 Human 5.9 pKi = 5.9 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.09.027
11282743 91409 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
CHEMBL222275 91409 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
42 8844 57 None -251 18 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmcl.2021.128028
56971 8844 57 None -251 18 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmcl.2021.128028
CHEMBL8412 8844 57 None -251 18 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmcl.2021.128028
135367403 171024 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4211303 171024 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
127029650 145044 0 None 5 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770581 145044 0 None 5 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
162672312 190545 0 None -4 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4795807 190545 0 None -4 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803872 190545 0 None -4 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
2921525 61644 14 None -3 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 375 8 1 4 4.7 COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL1379600 61644 14 None -3 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 375 8 1 4 4.7 COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL1613157 61644 14 None -3 3 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 375 8 1 4 4.7 COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1 10.1016/j.ejmech.2018.04.010
10478367 78445 0 None -281 7 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand
ChEMBL 439 5 1 6 2.8 COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 10.1016/j.bmcl.2005.07.024
CHEMBL196370 78445 0 None -281 7 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand
ChEMBL 439 5 1 6 2.8 COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 10.1016/j.bmcl.2005.07.024
CHEMBL430500 78445 0 None -281 7 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand
ChEMBL 439 5 1 6 2.8 COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 10.1016/j.bmcl.2005.07.024
164623862 192784 0 None -79 6 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 351 6 0 5 2.8 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 10.1016/j.ejmech.2021.113243
CHEMBL4870361 192784 0 None -79 6 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 351 6 0 5 2.8 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 10.1016/j.ejmech.2021.113243
122483254 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764307 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765844 144874 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 5 0 3 5.6 CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
135367403 171024 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4211303 171024 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
52952099 69357 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 365 5 1 5 3.9 Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782796 69357 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 365 5 1 5 3.9 Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
18137020 170708 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 360 7 1 4 2.5 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4207433 170708 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 360 7 1 4 2.5 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
137637994 162721 0 None 2 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4061131 162721 0 None 2 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
118626120 172568 0 None -23 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4247770 172568 0 None -23 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
57400829 75206 0 None 3 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 387 6 1 4 3.4 O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917352 75206 0 None 3 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 387 6 1 4 3.4 O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
11256720 8836 79 None -60255 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 3 1 5 2.5 O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1 10.1016/j.ejmech.2017.12.053
9444 8836 79 None -60255 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 3 1 5 2.5 O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1 10.1016/j.ejmech.2017.12.053
CHEMBL1083390 8836 79 None -60255 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 3 1 5 2.5 O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1 10.1016/j.ejmech.2017.12.053
DB12680 8836 79 None -60255 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 353 3 1 5 2.5 O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1 10.1016/j.ejmech.2017.12.053
46233383 205680 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 285 5 0 2 4.6 Cc1cccc(C)c1-c1ccccc1SCCN(C)C 10.1016/j.bmc.2010.01.035
CHEMBL584429 205680 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 285 5 0 2 4.6 Cc1cccc(C)c1-c1ccccc1SCCN(C)C 10.1016/j.bmc.2010.01.035
13069624 127379 0 None -2 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 382 5 0 8 0.6 Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360991 127379 0 None -2 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 382 5 0 8 0.6 Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3545931 127379 0 None -2 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 382 5 0 8 0.6 Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
134130447 149085 0 None -4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 402 9 0 5 4.5 c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1 10.1016/j.bmc.2016.12.039
CHEMBL3885319 149085 0 None -4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 402 9 0 5 4.5 c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1 10.1016/j.bmc.2016.12.039
118728526 124499 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 6 4.1 Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401489 124499 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 6 4.1 Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
135367917 170374 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4203526 170374 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
71458649 88205 0 None -5 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 370 7 1 5 2.3 O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159473 88205 0 None -5 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 370 7 1 5 2.3 O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
134153539 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3971383 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3990611 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
72734865 113092 0 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 268 1 3 3 2.0 NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2 10.1016/j.bmc.2013.10.010
CHEMBL3092756 113092 0 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 268 1 3 3 2.0 NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2 10.1016/j.bmc.2013.10.010
CHEMBL3139103 113092 0 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 268 1 3 3 2.0 NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2 10.1016/j.bmc.2013.10.010
134153539 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3971383 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3990611 161284 0 None -3 9 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 390 5 0 3 6.0 Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
155528967 178171 0 None -31 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 510 7 1 5 5.4 O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 10.1016/j.ejmech.2019.01.031
CHEMBL4462139 178171 0 None -31 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 510 7 1 5 5.4 O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 10.1016/j.ejmech.2019.01.031
155546350 180326 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 263 2 1 2 3.8 CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4531898 180326 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 263 2 1 2 3.8 CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12 10.1016/j.ejmech.2019.03.017
135367917 170374 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4203526 170374 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
168288545 198542 0 None -31 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 372 8 3 9 1.1 COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
CHEMBL5197737 198542 0 None -31 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 372 8 3 9 1.1 COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
44460918 212569 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 299 4 0 3 3.4 CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL83090 212569 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 299 4 0 3 3.4 CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
49756 211091 13 None -5 8 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm990550b
CHEMBL7143 211091 13 None -5 8 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 10.1021/jm990550b
136180316 124488 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 362 6 1 4 3.1 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401478 124488 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 362 6 1 4 3.1 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
57399866 78316 0 None 3 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1949974 78316 0 None 3 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1962960 78316 0 None 3 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
156018141 184700 0 None -36 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 439 9 0 5 3.4 COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1 10.1016/j.bmc.2020.115459
CHEMBL4645292 184700 0 None -36 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 439 9 0 5 3.4 COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1 10.1016/j.bmc.2020.115459
44352308 124265 0 None -177 12 Human 5.8 pKi = 5.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
CHEMBL339980 124265 0 None -177 12 Human 5.8 pKi = 5.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
118728514 124487 0 None -27 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 1 5 4.8 Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401477 124487 0 None -27 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 1 5 4.8 Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
118728511 124484 0 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 8 1 5 3.8 Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1 10.1016/j.bmcl.2015.02.042
CHEMBL3401474 124484 0 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 8 1 5 3.8 Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1 10.1016/j.bmcl.2015.02.042
162671033 190534 0 None -4 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4793296 190534 0 None -4 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4803797 190534 0 None -4 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 4 3.0 O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
11112531 108954 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 1 3 4.8 Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/j.bmc.2019.06.028
CHEMBL302723 108954 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 1 3 4.8 Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/j.bmc.2019.06.028
11112531 108954 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 417 6 1 3 4.8 Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL302723 108954 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 417 6 1 3 4.8 Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
142601318 192324 0 None 6 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863036 192324 0 None 6 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
2853434 124709 15 None 2 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 386 3 1 2 4.9 O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
CHEMBL3403335 124709 15 None 2 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 386 3 1 2 4.9 O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
134145143 157513 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 271 4 1 4 2.8 CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3956286 157513 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 271 4 1 4 2.8 CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2 10.1016/j.ejmech.2016.07.029
11132982 58682 0 None 9 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 8 1 6 4.1 O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL158592 58682 0 None 9 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 8 1 6 4.1 O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O 10.1021/jm020994z
90654674 116872 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 500 6 1 5 3.8 CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235746 116872 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 500 6 1 5 3.8 CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
164619075 192962 0 None -9 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 413 7 0 5 2.8 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4872713 192962 0 None -9 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 413 7 0 5 2.8 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
142601318 192324 0 None 6 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863036 192324 0 None 6 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
25107581 199410 0 None -14 3 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 505 12 1 7 3.7 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
CHEMBL521687 199410 0 None -14 3 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 505 12 1 7 3.7 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
10378785 23542 0 None -5 4 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 277 0 0 3 3.0 CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL124419 23542 0 None -5 4 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 277 0 0 3 3.0 CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
46206345 131386 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.5 COc1ccc(-c2ccccc2)cc1OC1CCNCC1 nan
CHEMBL3640613 131386 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.5 COc1ccc(-c2ccccc2)cc1OC1CCNCC1 nan
46206345 131386 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.5 COc1ccc(-c2ccccc2)cc1OC1CCNCC1 nan
CHEMBL3640613 131386 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.5 COc1ccc(-c2ccccc2)cc1OC1CCNCC1 nan
46233449 208771 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 287 6 0 5 2.3 COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1 10.1016/j.bmc.2010.01.035
CHEMBL608138 208771 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 287 6 0 5 2.3 COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1 10.1016/j.bmc.2010.01.035
164618510 192712 0 None -8 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 481 7 0 5 4.1 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4869198 192712 0 None -8 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 481 7 0 5 4.1 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
49862237 21779 0 None 6 3 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 395 6 0 5 4.3 COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1 10.1016/j.bmcl.2010.06.033
CHEMBL1209157 21779 0 None 6 3 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 395 6 0 5 4.3 COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1 10.1016/j.bmcl.2010.06.033
11783562 61176 0 None -4 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1 10.1021/jm020994z
CHEMBL160906 61176 0 None -4 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1 10.1021/jm020994z
5074 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
97 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
CHEMBL267777 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
DB12693 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
72711488 109362 0 None 2 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 382 9 1 5 2.4 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12 10.1021/jm400766k
CHEMBL2431041 109362 0 None 2 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 382 9 1 5 2.4 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12 10.1021/jm400766k
CHEMBL3040835 109362 0 None 2 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 382 9 1 5 2.4 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12 10.1021/jm400766k
76332577 113055 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 409 5 0 3 6.1 CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121419 113055 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 409 5 0 3 6.1 CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139022 113055 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 409 5 0 3 6.1 CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
71451458 88218 0 None -3 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 426 8 1 5 3.5 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159486 88218 0 None -3 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 426 8 1 5 3.5 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1 10.1016/j.ejmech.2012.07.043
118731358 124972 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 530 10 0 4 5.4 O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409041 124972 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 530 10 0 4 5.4 O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
25107716 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
8436 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
CHEMBL522691 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1021/jm3003679
11393128 189640 0 None -7 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 3.8 CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4791646 189640 0 None -7 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 3.8 CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
25107716 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2016.05.005
8436 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL522691 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.ejmech.2016.05.005
66801344 166201 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 7 2 3 5.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4100951 166201 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 7 2 3 5.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
122178699 128144 0 None 3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 397 7 0 5 4.6 CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1016/j.bmc.2020.115578
CHEMBL3581245 128144 0 None 3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 397 7 0 5 4.6 CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1016/j.bmc.2020.115578
164614709 191988 0 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 6 0 4 4.1 O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4857665 191988 0 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 6 0 4 4.1 O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
164622973 192902 0 None -6 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 397 6 0 4 4.5 CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
CHEMBL4871868 192902 0 None -6 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 397 6 0 4 4.5 CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
25107716 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
8436 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
CHEMBL522691 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmc.2014.01.016
44408630 146086 0 None 100 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 376 7 0 5 3.9 CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
CHEMBL379238 146086 0 None 100 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 376 7 0 5 3.9 CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
71678857 154049 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3928716 154049 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.ejmech.2016.07.029
92042877 155954 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3943658 155954 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
25107716 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmcl.2013.09.025
8436 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmcl.2013.09.025
CHEMBL522691 9130 43 None -3 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs
ChEMBL 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 10.1016/j.bmcl.2013.09.025
56944287 118881 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 515 9 1 6 4.8 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289998 118881 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 515 9 1 6 4.8 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
122178699 128144 0 None 3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 397 7 0 5 4.6 CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581245 128144 0 None 3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 397 7 0 5 4.6 CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
145946966 174376 0 None -7 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4209888 174376 0 None -7 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4300899 174376 0 None -7 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
164622973 192902 0 None -6 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 397 6 0 4 4.5 CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
CHEMBL4871868 192902 0 None -6 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 397 6 0 4 4.5 CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
162670302 189512 0 None 19 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 419 8 1 6 3.8 COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4789865 189512 0 None 19 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 419 8 1 6 3.8 COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
71062035 99891 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442994 99891 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmc.2014.01.016
71062035 99891 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442994 99891 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmcl.2013.09.025
11785183 91488 0 None 1 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/acs.jmedchem.5b00982
CHEMBL222755 91488 0 None 1 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/acs.jmedchem.5b00982
11785183 91488 0 None 1 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222755 91488 0 None 1 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
135458392 104201 5 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 209 0 2 3 2.2 CNC1=Nc2cccc(Cl)c2C(C)N1 10.1016/j.bmcl.2007.10.080
CHEMBL269964 104201 5 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 209 0 2 3 2.2 CNC1=Nc2cccc(Cl)c2C(C)N1 10.1016/j.bmcl.2007.10.080
46204728 131346 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
CHEMBL3640575 131346 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
46204728 131346 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
CHEMBL3640575 131346 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 nan
CHEMBL5084167 221678 0 None -63 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.1c00497
134137560 149483 0 None 6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 485 11 1 4 5.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3892201 149483 0 None 6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 485 11 1 4 5.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
162673308 189888 0 None 25 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 443 8 1 6 3.8 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4794688 189888 0 None 25 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 443 8 1 6 3.8 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1 10.1016/j.ejmech.2020.112395
18377409 212826 0 None - 1 Human 7.8 pKi = 7.8 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 1 3 4.0 O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL85249 212826 0 None - 1 Human 7.8 pKi = 7.8 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 1 3 4.0 O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3 10.1016/s0960-894x(02)00485-7
16006492 104245 7 None -3 6 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 195 0 2 3 2.0 CC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL270177 104245 7 None -3 6 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 195 0 2 3 2.0 CC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
10597140 69819 0 None 25 6 Human 7.8 pKi = 7.8 Binding
Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
CHEMBL1788231 69819 0 None 25 6 Human 7.8 pKi = 7.8 Binding
Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
5074 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1016/s0960-894x(00)00166-9
97 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1016/s0960-894x(00)00166-9
CHEMBL267777 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1016/s0960-894x(00)00166-9
DB12693 10105 80 None -36 30 Rat 7.8 pKi = 7.8 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1016/s0960-894x(00)00166-9
10767321 105045 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 486 6 0 4 4.4 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1 10.1021/jm970519e
CHEMBL274595 105045 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 486 6 0 4 4.4 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1 10.1021/jm970519e
10767321 105045 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 486 6 0 4 4.4 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL274595 105045 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 486 6 0 4 4.4 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1 10.1016/s0960-894x(00)00166-9
10715998 52002 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
CHEMBL152595 52002 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
44368754 53675 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 561 7 0 4 6.9 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1 10.1021/jm030841r
CHEMBL154090 53675 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 561 7 0 4 6.9 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1 10.1021/jm030841r
142601328 191782 0 None 39 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None 39 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
162664339 188907 0 None -14 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 10.1016/j.ejmech.2020.112149
CHEMBL4782149 188907 0 None -14 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 10.1016/j.ejmech.2020.112149
24865727 199892 0 None -10 11 Human 7.8 pKi = 7.8 Binding
Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor
ChEMBL 479 7 0 5 4.4 Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
CHEMBL522708 199892 0 None -10 11 Human 7.8 pKi = 7.8 Binding
Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor
ChEMBL 479 7 0 5 4.4 Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
5074 10105 80 None -69 30 Human 7.8 pKi = 7.8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030841r
97 10105 80 None -69 30 Human 7.8 pKi = 7.8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030841r
CHEMBL267777 10105 80 None -69 30 Human 7.8 pKi = 7.8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030841r
DB12693 10105 80 None -69 30 Human 7.8 pKi = 7.8 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030841r
76284721 111785 0 None 27 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 480 10 1 5 3.9 O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
CHEMBL3113597 111785 0 None 27 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 480 10 1 5 3.9 O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
72550645 120866 0 None -2 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 505 11 1 4 6.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326993 120866 0 None -2 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 505 11 1 4 6.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
16006492 104245 7 None -3 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 195 0 2 3 2.0 CC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.080
CHEMBL270177 104245 7 None -3 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 195 0 2 3 2.0 CC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.080
46205696 131369 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 0 2 3.8 COc1ccc(-c2ccccc2)cc1C1CCN(C)C1 nan
CHEMBL3640597 131369 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 0 2 3.8 COc1ccc(-c2ccccc2)cc1C1CCN(C)C1 nan
71459269 89735 0 None -660 8 Human 6.8 pKi = 6.8 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 555 7 0 4 6.3 Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 10.1021/jm300943r
CHEMBL2181166 89735 0 None -660 8 Human 6.8 pKi = 6.8 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 555 7 0 4 6.3 Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 10.1021/jm300943r
45273816 202560 0 None 79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 428 8 3 3 3.5 Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
CHEMBL557740 202560 0 None 79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 428 8 3 3 3.5 Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
1220 6975 55 None -75 44 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
31 6975 55 None -75 44 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
7 6975 55 None -75 44 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
CHEMBL56 6975 55 None -75 44 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
46205696 131369 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 0 2 3.8 COc1ccc(-c2ccccc2)cc1C1CCN(C)C1 nan
CHEMBL3640597 131369 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 0 2 3.8 COc1ccc(-c2ccccc2)cc1C1CCN(C)C1 nan
24873257 187035 0 None -10 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 289 2 1 3 3.2 c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4750414 187035 0 None -10 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 289 2 1 3 3.2 c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
11312173 188890 0 None -151 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 285 2 1 3 3.1 Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4782005 188890 0 None -151 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 285 2 1 3 3.1 Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
66801430 164493 0 None -2 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 457 7 2 3 4.9 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4081987 164493 0 None -2 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 457 7 2 3 4.9 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
66801625 165064 0 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 7 2 3 5.7 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
CHEMBL4088925 165064 0 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 493 7 2 3 5.7 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
156021073 184945 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 335 2 1 4 4.4 CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 10.1016/j.bmc.2020.115578
CHEMBL4649078 184945 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 335 2 1 4 4.4 CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 10.1016/j.bmc.2020.115578
90644077 118864 0 None -10 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 456 7 1 7 3.5 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3289981 118864 0 None -10 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 456 7 1 7 3.5 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
168279281 197801 0 None -26 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 342 7 3 8 1.1 Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5186821 197801 0 None -26 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 342 7 3 8 1.1 Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
71456677 87936 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 7 1 3 4.8 Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158027 87936 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 7 1 3 4.8 Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1 10.1016/j.ejmech.2012.07.043
155568794 182877 0 None -53 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 336 7 3 4 3.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4591410 182877 0 None -53 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 336 7 3 4 3.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1 10.1016/j.ejmech.2019.111857
122181344 128664 0 None -4 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 460 7 1 4 4.2 O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590096 128664 0 None -4 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 460 7 1 4 4.2 O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
164608896 191199 0 None -223 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4846146 191199 0 None -223 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
162666977 190514 0 None -7 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4787400 190514 0 None -7 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803559 190514 0 None -7 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
122483246 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763582 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765846 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
127049059 147591 0 None -154 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 404 6 1 5 3.6 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3818935 147591 0 None -154 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 404 6 1 5 3.6 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 10.1016/j.bmc.2016.06.011
52952202 69360 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 389 5 0 5 4.6 N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782800 69360 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 389 5 0 5 4.6 N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
155558408 181534 0 None -16 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 1.7 Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4560883 181534 0 None -16 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 1.7 Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
71462776 89738 0 None -125 7 Human 6.8 pKi = 6.8 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 460 5 0 3 5.5 CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 10.1021/jm300943r
CHEMBL2181169 89738 0 None -125 7 Human 6.8 pKi = 6.8 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 460 5 0 3 5.5 CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 10.1021/jm300943r
90654690 116853 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 418 9 1 5 2.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235727 116853 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 418 9 1 5 2.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
53361626 73201 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851948 73201 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216277 73201 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.04.060
122483246 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763582 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765846 144876 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 410 6 0 3 6.5 O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
162662435 190495 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 9 2 5 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4780228 190495 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 9 2 5 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803308 190495 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 9 2 5 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
11260739 91913 0 None 2 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
CHEMBL224929 91913 0 None 2 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
127036186 144192 0 None -4 19 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3753318 144192 0 None -4 19 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 10.1016/j.bmcl.2015.12.053
44324535 19884 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 293 3 2 4 3.2 CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
CHEMBL1190414 19884 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 293 3 2 4 3.2 CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
CHEMBL540821 19884 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 293 3 2 4 3.2 CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
155547197 180374 0 None -758 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 341 6 0 4 3.4 O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4533305 180374 0 None -758 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 341 6 0 4 3.4 O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
6918515 9390 38 None -4 7 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10.1021/jm990550b
71 9390 38 None -4 7 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10.1021/jm990550b
CHEMBL7318 9390 38 None -4 7 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10.1021/jm990550b
55479093 88196 1 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 366 7 1 5 2.6 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159464 88196 1 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 366 7 1 5 2.6 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
46206018 131376 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 265 2 0 1 4.4 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C nan
CHEMBL3640604 131376 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 265 2 0 1 4.4 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C nan
46206018 131376 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 265 2 0 1 4.4 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C nan
CHEMBL3640604 131376 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 265 2 0 1 4.4 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C nan
11739679 176631 0 None -776 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD
ChEMBL 353 3 2 5 2.8 Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1 10.1016/j.bmcl.2004.10.064
CHEMBL444015 176631 0 None -776 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD
ChEMBL 353 3 2 5 2.8 Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1 10.1016/j.bmcl.2004.10.064
168298474 199498 0 None -3 3 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 384 8 0 5 3.9 CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1 10.1016/j.bmcl.2021.128275
CHEMBL5219968 199498 0 None -3 3 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 384 8 0 5 3.9 CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1 10.1016/j.bmcl.2021.128275
57399090 75196 0 None -8 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 440 8 1 6 2.7 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1 10.1016/j.bmc.2011.09.044
CHEMBL1917342 75196 0 None -8 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 440 8 1 6 2.7 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1 10.1016/j.bmc.2011.09.044
168284197 197635 0 None -12 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 515 12 4 9 3.6 COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2021.113931
CHEMBL5184538 197635 0 None -12 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 515 12 4 9 3.6 COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2021.113931
888197 83510 4 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 241 5 0 2 3.3 CN(C)CCOc1ccccc1-c1ccccc1 10.1016/j.bmc.2010.01.035
CHEMBL20666 83510 4 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 241 5 0 2 3.3 CN(C)CCOc1ccccc1-c1ccccc1 10.1016/j.bmc.2010.01.035
10430623 25447 24 None -1412 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 392 3 2 5 3.0 O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12 10.1021/jm1007825
CHEMBL1277105 25447 24 None -1412 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 392 3 2 5 3.0 O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12 10.1021/jm1007825
162669046 190522 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4789585 190522 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803681 190522 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
86288950 119420 0 None -52 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3233666 119420 0 None -52 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3302931 119420 0 None -52 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
91937907 174419 0 None 17 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 368 7 0 4 4.2 COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4218586 174419 0 None 17 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 368 7 0 4 4.2 COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4301638 174419 0 None 17 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 368 7 0 4 4.2 COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
122483290 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765511 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765847 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
44461064 212368 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 287 4 0 4 2.3 COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL81449 212368 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 287 4 0 4 2.3 COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
168268929 196809 0 None -3 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 456 9 5 7 4.4 Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5171734 196809 0 None -3 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 456 9 5 7 4.4 Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
12005903 57998 13 None -117 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 482 5 0 7 4.0 CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1 10.1016/j.bmcl.2015.03.049
CHEMBL1580288 57998 13 None -117 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 482 5 0 7 4.0 CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1 10.1016/j.bmcl.2015.03.049
44460739 212328 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 3 0 3 3.6 Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1 10.1016/s0960-894x(02)00438-9
CHEMBL81069 212328 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 3 0 3 3.6 Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1 10.1016/s0960-894x(02)00438-9
42626289 154858 0 None -5 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1021/jm8014553
CHEMBL393492 154858 0 None -5 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1021/jm8014553
11292933 63168 45 None -794 9 Human 6.8 pKi = 6.8 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 415 5 1 4 3.4 Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1631540 63168 45 None -794 9 Human 6.8 pKi = 6.8 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 415 5 1 4 3.4 Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL5085390 221743 0 None -12 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
155528865 178168 0 None -33 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 347 6 0 3 4.0 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4462108 178168 0 None -33 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 347 6 0 3 4.0 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 10.1016/j.bmc.2020.115943
162645252 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4743284 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4802393 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
1150 10650 121 None -6 25 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 10.1016/j.ejmech.2019.111705
125 10650 121 None -6 25 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 10.1016/j.ejmech.2019.111705
CHEMBL6640 10650 121 None -6 25 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 10.1016/j.ejmech.2019.111705
DB08653 10650 121 None -6 25 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 10.1016/j.ejmech.2019.111705
122483290 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765511 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765847 144877 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.9 O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
145967457 171130 0 None 1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 428 7 1 4 3.5 O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4212698 171130 0 None 1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 428 7 1 4 3.5 O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
12843124 17036 27 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 177 1 1 2 1.5 COc1ccc2c(c1)CC[C@@H](N)C2 10.1021/jm030826m
CHEMBL1161325 17036 27 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 177 1 1 2 1.5 COc1ccc2c(c1)CC[C@@H](N)C2 10.1021/jm030826m
9891002 114185 0 None -1584 7 Human 5.8 pKi = 5.8 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 472 4 2 6 4.6 Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1 10.1016/s0960-894x(01)00558-3
CHEMBL318018 114185 0 None -1584 7 Human 5.8 pKi = 5.8 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 472 4 2 6 4.6 Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1 10.1016/s0960-894x(01)00558-3
10785644 103879 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12 10.1021/jm970519e
CHEMBL267543 103879 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12 10.1021/jm970519e
10785644 103879 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12 10.1016/s0960-894x(00)00166-9
CHEMBL267543 103879 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12 10.1016/s0960-894x(00)00166-9
44368383 126495 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
CHEMBL347511 126495 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
127050632 147521 0 None -89 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 6 1 5 4.7 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3818124 147521 0 None -89 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 6 1 5 4.7 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.06.011
127049059 147591 0 None -154 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 404 6 1 5 3.6 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3818935 147591 0 None -154 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 404 6 1 5 3.6 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 10.1016/j.bmc.2016.06.011
162663829 190499 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 439 8 2 5 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4779965 190499 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 439 8 2 5 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803379 190499 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 439 8 2 5 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
155528865 178168 0 None -33 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 347 6 0 3 4.0 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4462108 178168 0 None -33 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 347 6 0 3 4.0 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 10.1016/j.bmc.2020.115943
164623862 192784 0 None -79 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 351 6 0 5 2.8 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 10.1016/j.ejmech.2021.113243
CHEMBL4870361 192784 0 None -79 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 351 6 0 5 2.8 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 10.1016/j.ejmech.2021.113243
127050632 147521 0 None -89 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 6 1 5 4.7 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3818124 147521 0 None -89 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 6 1 5 4.7 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.06.011
44393022 71612 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182006 71612 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
168273329 197347 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 368 6 0 3 3.5 CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5180129 197347 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 368 6 0 3 3.5 CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.2c00633
10106205 213916 1 None 1 4 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1021/jm030030n
CHEMBL92221 213916 1 None 1 4 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1021/jm030030n
44461066 110930 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 4 0 3 3.6 Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL309523 110930 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 4 0 3 3.6 Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
127026751 144458 0 None 23 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
CHEMBL3758622 144458 0 None 23 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
90178632 152206 0 None 9 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 468 10 1 5 4.1 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3914155 152206 0 None 9 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 468 10 1 5 4.1 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
134151980 159969 0 None 8 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 570 14 1 6 5.1 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3977072 159969 0 None 8 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 570 14 1 6 5.1 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1 10.1016/j.ejmech.2016.05.005
71456783 88212 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159480 88212 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
71449644 88216 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F 10.1016/j.ejmech.2012.07.043
CHEMBL2159484 88216 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F 10.1016/j.ejmech.2012.07.043
118731357 124971 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 516 9 0 4 5.0 O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409040 124971 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 516 9 0 4 5.0 O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
156016485 184552 0 None -15 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 475 8 0 7 4.7 O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3 10.1016/j.bmc.2020.115459
CHEMBL4642981 184552 0 None -15 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 475 8 0 7 4.7 O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3 10.1016/j.bmc.2020.115459
57384073 83980 0 None -19 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 512 9 0 5 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL2079256 83980 0 None -19 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 512 9 0 5 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
139488539 178203 0 None 19 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 307 2 1 2 4.0 CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4462820 178203 0 None 19 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 307 2 1 2 4.0 CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12 10.1016/j.ejmech.2019.03.017
156009593 183948 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 303 2 0 1 4.6 CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1 10.1016/j.bmc.2019.115262
CHEMBL4634558 183948 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 303 2 0 1 4.6 CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1 10.1016/j.bmc.2019.115262
142601328 191782 0 None 39 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4854605 191782 0 None 39 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
155557720 181426 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 494 10 1 7 3.2 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4558286 181426 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 494 10 1 7 3.2 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
54758297 72781 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 349 6 1 3 3.7 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm200547z
CHEMBL1836856 72781 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 349 6 1 3 3.7 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm200547z
135367857 171383 0 None 1 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None 1 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
132604118 188772 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 420 8 1 7 2.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4780452 188772 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 420 8 1 7 2.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
10106205 213916 1 None -1 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1021/jm030826m
CHEMBL92221 213916 1 None -1 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1021/jm030826m
135367857 171383 0 None 1 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215875 171383 0 None 1 8 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
10106205 213916 1 None -1 4 Rat 7.8 pKi = 7.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1016/s0960-894x(02)00925-3
CHEMBL92221 213916 1 None -1 4 Rat 7.8 pKi = 7.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 251 2 2 3 3.0 Cc1c(NC2=NCCN2)cccc1-c1ccccc1 10.1016/s0960-894x(02)00925-3
11025015 56973 0 None -3 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1 10.1021/jm020994z
CHEMBL157081 56973 0 None -3 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1 10.1021/jm020994z
25107518 194063 0 None -20 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis
ChEMBL 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL492871 194063 0 None -20 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis
ChEMBL 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
44324628 119152 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 257 2 2 4 3.1 Cc1c(NC2=NCCN2)cccc1-c1cccs1 10.1016/s0960-894x(02)00925-3
CHEMBL329548 119152 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 257 2 2 4 3.1 Cc1c(NC2=NCCN2)cccc1-c1cccs1 10.1016/s0960-894x(02)00925-3
90656695 117773 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 8 1 4 3.8 CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262429 117773 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 8 1 4 3.8 CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
168282260 197782 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis
ChEMBL 232 3 0 4 2.6 COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1 10.1021/acs.jmedchem.2c00633
CHEMBL5186652 197782 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis
ChEMBL 232 3 0 4 2.6 COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1 10.1021/acs.jmedchem.2c00633
11595790 72775 0 None 6 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 368 6 1 4 3.2 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1 10.1021/jm200547z
CHEMBL1836790 72775 0 None 6 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 368 6 1 4 3.2 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1 10.1021/jm200547z
11646498 109281 0 None -7 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 375 11 1 5 2.3 CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
CHEMBL2431051 109281 0 None -7 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 375 11 1 5 2.3 CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
CHEMBL3040382 109281 0 None -7 2 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 375 11 1 5 2.3 CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
9803482 211050 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 443 7 1 4 5.0 COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL71224 211050 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 443 7 1 4 5.0 COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
127051845 147507 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 309 6 0 3 3.7 COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3817898 147507 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 309 6 0 3 3.7 COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
50878551 97520 61 None 1 18 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2013.03.066
CHEMBL2391541 97520 61 None 1 18 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2013.03.066
156012890 184222 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4638770 184222 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1 10.1016/j.bmc.2019.115262
162645252 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4743284 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4802393 190404 0 None -2 7 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 389 7 0 3 5.0 Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 10.1016/j.bmc.2020.115943
44424661 151325 0 None -8 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 484 10 0 10 1.8 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
CHEMBL390734 151325 0 None -8 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 484 10 0 10 1.8 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
118706287 127309 0 None -14 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310114 127309 0 None -14 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545466 127309 0 None -14 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2 10.1016/j.bmc.2014.05.027
42625359 193626 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 348 6 0 2 4.2 O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1 10.1021/jm8014553
CHEMBL489448 193626 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 348 6 0 2 4.2 O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1 10.1021/jm8014553
136216703 85680 0 None -79 5 Human 5.8 pKi = 5.8 Binding
Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor
ChEMBL 482 2 4 7 4.0 N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 10.1016/s0960-894x(99)00075-x
CHEMBL2112936 85680 0 None -79 5 Human 5.8 pKi = 5.8 Binding
Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor
ChEMBL 482 2 4 7 4.0 N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 10.1016/s0960-894x(99)00075-x
9796627 103428 0 None -54 7 Human 5.8 pKi = 5.8 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 308 4 1 4 3.1 CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 10.1021/jm010943m
CHEMBL263700 103428 0 None -54 7 Human 5.8 pKi = 5.8 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 308 4 1 4 3.1 CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 10.1021/jm010943m
15560577 192120 9 None -31 10 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 398 5 1 5 3.8 CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.1c00726
CHEMBL4859858 192120 9 None -31 10 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 398 5 1 5 3.8 CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.1c00726
23906630 124707 5 None -2 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 404 3 1 2 2.9 O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
CHEMBL3403333 124707 5 None -2 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 404 3 1 2 2.9 O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
155566439 182577 0 None -69 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1 10.1016/j.ejmech.2019.06.022
CHEMBL4584325 182577 0 None -69 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1 10.1016/j.ejmech.2019.06.022
45273807 202583 0 None 28 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 400 6 3 3 2.7 Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
CHEMBL558025 202583 0 None 28 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 400 6 3 3 2.7 Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
71451441 88148 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 6 1 5 3.6 O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2 10.1016/j.ejmech.2012.07.043
CHEMBL2159320 88148 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 6 1 5 3.6 O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2 10.1016/j.ejmech.2012.07.043
155552826 180871 0 None 37 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 269 3 1 4 2.8 CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12 10.1039/C8MD00313K
CHEMBL4544802 180871 0 None 37 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 269 3 1 4 2.8 CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12 10.1039/C8MD00313K
53248361 68856 0 None -104 7 Human 6.8 pKi = 6.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 568 7 0 5 3.2 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 10.1021/jm1009956
CHEMBL1774991 68856 0 None -104 7 Human 6.8 pKi = 6.8 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 568 7 0 5 3.2 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 10.1021/jm1009956
90656686 117760 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 366 7 1 4 3.3 CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262416 117760 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 366 7 1 4 3.3 CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
90656679 117759 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 387 6 0 3 4.1 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262415 117759 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 387 6 0 3 4.1 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1 10.1016/j.ejmech.2014.04.034
90656674 117749 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 311 5 1 4 2.7 CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262399 117749 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 311 5 1 4 2.7 CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
46233351 205954 0 None 4 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 270 5 0 3 3.3 Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1 10.1016/j.bmc.2010.01.035
CHEMBL589524 205954 0 None 4 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 270 5 0 3 3.3 Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1 10.1016/j.bmc.2010.01.035
127027390 144617 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 0 4 3.5 CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
CHEMBL3759927 144617 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 0 4 3.5 CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
168293886 198959 0 None -2 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 488 8 0 4 4.5 O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3 10.1016/j.ejmech.2022.114319
CHEMBL5204088 198959 0 None -2 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 488 8 0 4 4.5 O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3 10.1016/j.ejmech.2022.114319
155531065 178392 0 None -229 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 332 6 3 3 4.5 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4465414 178392 0 None -229 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 332 6 3 3 4.5 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1 10.1016/j.ejmech.2019.111857
1355 8792 88 None -14 16 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1016/j.ejmech.2022.114319
142 8792 88 None -14 16 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1016/j.ejmech.2022.114319
CHEMBL478 8792 88 None -14 16 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1016/j.ejmech.2022.114319
DB12110 8792 88 None -14 16 Human 6.8 pKi = 6.8 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1016/j.ejmech.2022.114319
44461052 212655 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 391 4 0 3 4.5 CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL83802 212655 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 391 4 0 3 4.5 CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
90654689 116852 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 404 8 1 5 2.2 CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235726 116852 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 404 8 1 5 2.2 CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
127028634 144632 0 None 4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 7 1 4 3.0 Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3760121 144632 0 None 4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 7 1 4 3.0 Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
44424671 150242 0 None -2 2 Rat 4.8 pKi = 4.8 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 369 4 1 7 0.2 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2007.05.017
CHEMBL389842 150242 0 None -2 2 Rat 4.8 pKi = 4.8 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 369 4 1 7 0.2 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2007.05.017
137650961 164112 0 None 3 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4077538 164112 0 None 3 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
145982506 172174 0 None -11 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4238029 172174 0 None -11 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
145987559 173927 0 None 26 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 441 7 2 5 2.5 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4290738 173927 0 None 26 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 441 7 2 5 2.5 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O 10.1039/C8MD00168E
44341131 16247 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 393 5 1 6 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL111956 16247 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 393 5 1 6 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1 10.1016/s0960-894x(02)00690-x
168291978 198792 0 None 1 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 482 6 3 7 4.2 Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5201719 198792 0 None 1 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 482 6 3 7 4.2 Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
118728527 124501 0 None -7 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 424 8 0 6 4.1 Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401490 124501 0 None -7 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 424 8 0 6 4.1 Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
71678345 96458 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 396 4 0 2 5.7 FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376455 96458 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 396 4 0 2 5.7 FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
24901425 69368 0 None -10 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 391 6 2 5 4.5 N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782811 69368 0 None -10 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 391 6 2 5 4.5 N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
44460639 170120 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 285 4 0 3 2.8 CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL419101 170120 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 285 4 0 3 2.8 CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
155569022 183215 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4592962 183215 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4596261 183215 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
71678345 96458 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 396 4 0 2 5.7 FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376455 96458 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 396 4 0 2 5.7 FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1 10.1016/j.bmc.2013.02.038
168268997 196750 0 None -23 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 410 7 3 8 2.4 Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5170808 196750 0 None -23 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 410 7 3 8 2.4 Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
168277941 197462 0 None -7 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 374 9 2 4 1.8 NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
CHEMBL5181868 197462 0 None -7 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 374 9 2 4 1.8 NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
155519516 183137 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4447659 183137 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595677 183137 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
53322759 63786 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 4.9 FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644272 63786 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 4.9 FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
145971390 171413 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4216244 171413 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.8b00828
71451345 87946 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 398 6 1 3 4.4 CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158037 87946 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 398 6 1 3 4.4 CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1 10.1016/j.ejmech.2012.07.043
137642224 164870 0 None -758 5 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 323 3 2 6 1.3 CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2022.114645
CHEMBL4086515 164870 0 None -758 5 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 323 3 2 6 1.3 CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2022.114645
127027389 144571 0 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 0 4 4.0 CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759570 144571 0 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 0 4 4.0 CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
118728506 124481 0 None -4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 414 8 2 4 3.4 NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401469 124481 0 None -4 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 414 8 2 4 3.4 NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
42618261 188330 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 472 8 0 7 4.0 COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
CHEMBL476616 188330 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 472 8 0 7 4.0 COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
56850665 78280 0 None -11 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 334 7 1 5 2.4 O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926749 78280 0 None -11 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 334 7 1 5 2.4 O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962697 78280 0 None -11 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 334 7 1 5 2.4 O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
162659577 188137 0 None -17 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 475 7 1 6 4.7 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4763106 188137 0 None -17 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 475 7 1 6 4.7 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 10.1016/j.ejmech.2020.112149
44324402 20211 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 276 2 2 4 2.9 Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1 10.1016/s0960-894x(02)00925-3
CHEMBL1192985 20211 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 276 2 2 4 2.9 Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1 10.1016/s0960-894x(02)00925-3
CHEMBL544315 20211 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 276 2 2 4 2.9 Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1 10.1016/s0960-894x(02)00925-3
CHEMBL5275931 200656 0 None -26 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 629 10 0 8 5.4 O=C1CC2CCc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2023.117256
71727066 98040 0 None -1 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 338 3 0 5 2.7 COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL2401936 98040 0 None -1 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 338 3 0 5 2.7 COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL3215930 98040 0 None -1 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 338 3 0 5 2.7 COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1 10.1016/j.bmcl.2013.05.062
46206023 131381 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 1 2 3.7 COc1ccc(C)cc1-c1ccccc1C1CCNC1 nan
CHEMBL3640609 131381 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 1 2 3.7 COc1ccc(C)cc1-c1ccccc1C1CCNC1 nan
46206023 131381 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 1 2 3.7 COc1ccc(C)cc1-c1ccccc1C1CCNC1 nan
CHEMBL3640609 131381 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 1 2 3.7 COc1ccc(C)cc1-c1ccccc1C1CCNC1 nan
44461045 111507 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 403 4 0 3 4.7 Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL310594 111507 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 403 4 0 3 4.7 Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
76325347 113172 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 439 6 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121420 113172 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 439 6 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139440 113172 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 439 6 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
127028797 145111 0 None 3 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3771309 145111 0 None 3 3 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
127026444 144625 0 None 33 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 4.8 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3760017 144625 0 None 33 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 4.8 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
145985224 172267 0 None -4 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 535 6 0 7 5.0 O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4240162 172267 0 None -4 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 535 6 0 7 5.0 O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
71458623 88135 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 6 3.9 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159308 88135 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 6 3.9 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1 10.1016/j.ejmech.2012.07.043
156021535 184963 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 257 2 0 2 3.8 CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1 10.1016/j.bmc.2019.115262
CHEMBL4649289 184963 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 257 2 0 2 3.8 CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1 10.1016/j.bmc.2019.115262
56945043 163184 0 None -2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4066532 163184 0 None -2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
156013801 184061 0 None 26 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 278 1 0 2 3.5 CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
CHEMBL4636329 184061 0 None 26 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 278 1 0 2 3.5 CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
127051845 147507 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 309 6 0 3 3.7 COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3817898 147507 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 309 6 0 3 3.7 COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
50878551 97520 61 None 1 18 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2013.03.066
CHEMBL2391541 97520 61 None 1 18 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2013.03.066
73346042 98609 5 None -173 17 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1021/acs.jmedchem.2c00633
CHEMBL2413153 98609 5 None -173 17 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1021/acs.jmedchem.2c00633
73346042 98609 5 None -173 17 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
CHEMBL2413153 98609 5 None -173 17 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
15542627 210988 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 432 7 2 4 3.3 NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL70869 210988 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 432 7 2 4 3.3 NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
136152966 102368 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 289 3 2 4 2.9 COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2 10.1016/j.bmcl.2007.10.078
CHEMBL257744 102368 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 289 3 2 4 2.9 COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2 10.1016/j.bmcl.2007.10.078
11277147 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3092759 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3139188 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2013.10.010
162664480 188987 0 None 26 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 441 9 0 5 5.2 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4783043 188987 0 None 26 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 441 9 0 5 5.2 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1 10.1016/j.ejmech.2020.112395
44374298 61172 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 278 5 0 4 3.8 Cc1sc(SCCN(C)C)nc1-c1ccccc1 10.1016/j.bmcl.2003.11.050
CHEMBL160903 61172 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 278 5 0 4 3.8 Cc1sc(SCCN(C)C)nc1-c1ccccc1 10.1016/j.bmcl.2003.11.050
145964086 170953 0 None 5 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 8 1 4 4.2 CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4210561 170953 0 None 5 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 8 1 4 4.2 CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
44439394 151900 0 None 398 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 308 3 2 2 4.3 CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1 10.1016/j.bmcl.2007.01.093
CHEMBL391191 151900 0 None 398 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 308 3 2 2 4.3 CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1 10.1016/j.bmcl.2007.01.093
3377940 98554 21 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 278 2 2 2 3.4 COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL241098 98554 21 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 278 2 2 2 3.4 COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
136152972 101999 0 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL256047 101999 0 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
168277502 197494 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 468 8 0 5 6.2 S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3 10.1016/j.ejmech.2022.114319
CHEMBL5182383 197494 0 None -1 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 468 8 0 5 6.2 S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3 10.1016/j.ejmech.2022.114319
155533534 178663 0 None -131 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 514 7 1 5 5.3 O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4469537 178663 0 None -131 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 514 7 1 5 5.3 O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
90654848 119474 0 None 1 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233673 119474 0 None 1 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304318 119474 0 None 1 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1 10.1016/j.ejmech.2014.01.065
145974184 171402 0 None 50 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 416 7 1 4 3.8 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00828
CHEMBL4216040 171402 0 None 50 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 416 7 1 4 3.8 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00828
145988913 173948 0 None 23 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 475 7 2 5 3.2 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4291141 173948 0 None 23 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 475 7 2 5 3.2 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O 10.1039/C8MD00168E
18377388 212757 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 394 6 0 3 4.9 CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/s0960-894x(02)00485-7
CHEMBL84660 212757 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 394 6 0 3 4.9 CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/s0960-894x(02)00485-7
71602587 96455 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376448 96455 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
137652044 163946 0 None 2 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 464 6 0 5 3.8 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4075422 163946 0 None 2 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 464 6 0 5 3.8 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmc.2017.04.046
71727064 109185 0 None -3 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 372 4 1 5 2.7 O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12 10.1016/j.bmcl.2013.05.062
CHEMBL3039719 109185 0 None -3 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 372 4 1 5 2.7 O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12 10.1016/j.bmcl.2013.05.062
CHEMBL3216145 109185 0 None -3 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 372 4 1 5 2.7 O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12 10.1016/j.bmcl.2013.05.062
9872676 84970 0 None -4365 17 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 84970 0 None -4365 17 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
71602587 96455 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376448 96455 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
12374770 182282 2 None 20 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 268 7 2 2 2.5 O=C(CCNCc1ccccc1)NCc1ccccc1 10.1016/j.bmcl.2016.06.080
CHEMBL4577789 182282 2 None 20 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 268 7 2 2 2.5 O=C(CCNCc1ccccc1)NCc1ccccc1 10.1016/j.bmcl.2016.06.080
45272864 203329 0 None 6 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 338 5 3 3 1.5 Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1 10.1016/j.bmcl.2009.06.038
CHEMBL563760 203329 0 None 6 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 338 5 3 3 1.5 Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1 10.1016/j.bmcl.2009.06.038
127029651 144999 0 None 5 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 454 6 2 5 2.4 Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C 10.1016/j.ejmech.2016.02.024
CHEMBL3770110 144999 0 None 5 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 454 6 2 5 2.4 Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C 10.1016/j.ejmech.2016.02.024
CHEMBL5080719 221481 0 None -64 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3o2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
155561915 183249 0 None -109 5 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4585051 183249 0 None -109 5 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4596544 183249 0 None -109 5 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1016/j.bmc.2019.06.028
71460468 88200 0 None -5 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 403 7 1 4 4.2 CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159468 88200 0 None -5 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 403 7 1 4 4.2 CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1 10.1016/j.ejmech.2012.07.043
118729733 124712 0 None -4 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 394 4 1 3 5.4 O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403338 124712 0 None -4 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 394 4 1 3 5.4 O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2015.03.049
90654702 116865 0 None -44 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 440 8 1 4 3.2 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235739 116865 0 None -44 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 440 8 1 4 3.2 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
164615095 191726 0 None -13 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 414 7 0 6 2.2 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4853700 191726 0 None -13 5 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 414 7 0 6 2.2 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2021.128028
11675876 194293 0 None -54 3 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 8 0 4 3.9 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL494316 194293 0 None -54 3 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 8 0 4 3.9 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
13069598 127393 0 None -2 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360998 127393 0 None -2 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546116 127393 0 None -2 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
90656680 117758 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 343 6 0 3 4.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262414 117758 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 343 6 0 3 4.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2014.04.034
90469114 191201 0 None -588 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 426 3 1 6 3.5 O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
CHEMBL4846153 191201 0 None -588 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 426 3 1 6 3.5 O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
42618258 196514 0 None -47 2 Human 4.8 pKi = 4.8 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 426 5 0 5 4.2 Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL515789 196514 0 None -47 2 Human 4.8 pKi = 4.8 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 426 5 0 5 4.2 Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
11697434 137247 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 419 6 0 6 3.9 COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2005.05.059
CHEMBL368044 137247 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 419 6 0 6 3.9 COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2005.05.059
10499156 120868 1 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/acs.jmedchem.2c00633
CHEMBL332701 120868 1 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/acs.jmedchem.2c00633
10084076 104692 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm030030n
CHEMBL27251 104692 0 None 1 9 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm030030n
68788 214386 14 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 348 3 2 3 1.3 CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
CHEMBL95067 214386 14 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 348 3 2 3 1.3 CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
134138168 154469 0 None -1 10 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None -1 10 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
76325351 113056 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121437 113056 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139023 113056 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
76336179 113175 0 None 18 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 4 0 3 5.6 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
CHEMBL3121421 113175 0 None 18 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 4 0 3 5.6 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
CHEMBL3139443 113175 0 None 18 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 4 0 3 5.6 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
137653850 165824 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4096866 165824 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2016.02.024
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2016.02.024
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2016.02.024
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2016.02.024
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2016.02.024
90654686 116884 0 None 21 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 461 7 1 6 2.6 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235758 116884 0 None 21 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 461 7 1 6 2.6 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
168275477 197230 0 None 263 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 388 9 5 7 3.1 Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5178499 197230 0 None 263 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 388 9 5 7 3.1 Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
127037922 143765 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 508 10 0 4 5.4 O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3745853 143765 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 508 10 0 4 5.4 O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2015.11.041
127041258 143858 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 8 0 4 4.1 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747114 143858 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 8 0 4 4.1 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2015.11.041
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.022
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.022
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.022
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.022
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.022
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2012.07.043
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2012.07.043
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2012.07.043
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2012.07.043
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2012.07.043
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.07.027
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.07.027
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.07.027
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.07.027
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.07.027
118731348 124963 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 10 1 4 3.9 NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409032 124963 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 10 1 4 3.9 NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2014.12.041
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2020.112437
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2020.112437
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2020.112437
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2020.112437
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2020.112437
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2018.01.093
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2018.01.093
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2018.01.093
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2018.01.093
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2018.01.093
139488740 176927 0 None 97 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 258 2 2 3 1.8 Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4444268 176927 0 None 97 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 258 2 2 3 1.8 Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12 10.1016/j.ejmech.2019.03.017
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.01.031
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.01.031
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.01.031
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.01.031
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.01.031
156020374 184841 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4647335 184841 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1 10.1016/j.bmc.2019.115262
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C8MD00168E
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C8MD00168E
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C8MD00168E
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C8MD00168E
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C8MD00168E
11358099 187185 0 None -17 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 285 3 1 4 2.8 COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4752099 187185 0 None -17 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 285 3 1 4 2.8 COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
56944951 163416 0 None -6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 7 2 3 5.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
CHEMBL4069237 163416 0 None -6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 7 2 3 5.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
71061607 99896 0 None 48 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442999 99896 0 None 48 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
71061607 99896 0 None 48 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442999 99896 0 None 48 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.05.062
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.05.062
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.05.062
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.05.062
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.05.062
10084076 104692 0 None -1 9 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm9911433
CHEMBL27251 104692 0 None -1 9 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm9911433
10084076 104692 0 None -1 9 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm0108505
CHEMBL27251 104692 0 None -1 9 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 262 0 1 2 2.8 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N 10.1021/jm0108505
134137104 149470 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
CHEMBL3892079 149470 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C 10.1016/j.ejmech.2016.07.029
134138168 154469 0 None -1 10 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1016/j.ejmech.2016.07.029
CHEMBL3931889 154469 0 None -1 10 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1016/j.ejmech.2016.07.029
11277147 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3092759 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3139188 113118 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 267 1 3 2 1.2 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 10.1016/j.bmc.2014.05.027
11697434 137247 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 419 6 0 6 3.9 COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2007.03.054
CHEMBL368044 137247 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 419 6 0 6 3.9 COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2007.03.054
66801120 118891 0 None -5 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 501 7 1 5 5.3 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3290007 118891 0 None -5 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 501 7 1 5 5.3 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
135398737 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2014.11.008
38 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2014.11.008
722 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2014.11.008
CHEMBL42 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2014.11.008
DB00363 7745 93 None -13 90 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmc.2014.11.008
1342 6824 49 None -13 19 Rat 7.7 pKi = 7.7 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030826m
3 6824 49 None -13 19 Rat 7.7 pKi = 7.7 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030826m
CHEMBL277120 6824 49 None -13 19 Rat 7.7 pKi = 7.7 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030826m
162661196 188240 0 None -24 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4764468 188240 0 None -24 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 10.1016/j.ejmech.2020.112149
18663036 88595 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccccc1-c1ccccc1N1CCNCC1 10.1021/jm3003679
CHEMBL2164344 88595 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccccc1-c1ccccc1N1CCNCC1 10.1021/jm3003679
134133483 149987 0 None 5 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 614 16 1 7 5.5 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3896355 149987 0 None 5 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 614 16 1 7 5.5 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
44266317 214722 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 349 4 0 3 4.4 O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21 10.1016/s0960-894x(03)00077-5
CHEMBL9696 214722 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 349 4 0 3 4.4 O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21 10.1016/s0960-894x(03)00077-5
117209858 191333 1 None -1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4848305 191333 1 None -1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL5080955 221491 0 None -2 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(Cl)c1 10.1021/acs.jmedchem.1c00497
122196381 131073 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 485 8 0 6 6.3 Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1 10.1016/j.bmcl.2015.09.045
CHEMBL3634821 131073 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 485 8 0 6 6.3 Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1 10.1016/j.bmcl.2015.09.045
156017272 184431 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 287 2 0 1 4.1 CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4641478 184431 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 287 2 0 1 4.1 CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1 10.1016/j.bmc.2019.115262
156019520 184778 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 257 2 0 2 3.8 CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1 10.1016/j.bmc.2019.115262
CHEMBL4646359 184778 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 257 2 0 2 3.8 CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1 10.1016/j.bmc.2019.115262
66800959 164217 0 None -8 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 413 6 2 3 3.7 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4078873 164217 0 None -8 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 413 6 2 3 3.7 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
118706296 127303 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 308 2 3 2 1.3 CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3310119 127303 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 308 2 3 2 1.3 CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3545441 127303 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 308 2 3 2 1.3 CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
71151588 125036 0 None -1778 10 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 518 9 1 7 3.6 NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.ejmech.2014.12.045
CHEMBL3409256 125036 0 None -1778 10 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
ChEMBL 518 9 1 7 3.6 NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.ejmech.2014.12.045
66801333 118865 0 None 1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 470 8 1 7 3.9 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3289982 118865 0 None 1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 470 8 1 7 3.9 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
46205702 131374 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 257 2 1 1 4.1 Clc1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3640602 131374 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 257 2 1 1 4.1 Clc1ccc(-c2ccccc2C2CCNC2)cc1 nan
46205702 131374 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 257 2 1 1 4.1 Clc1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL3640602 131374 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 257 2 1 1 4.1 Clc1ccc(-c2ccccc2C2CCNC2)cc1 nan
CHEMBL5287809 201175 0 None -218 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 615 10 0 8 5.0 O=C1CC2Cc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2023.117256
2948971 79986 9 None -25 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 397 2 3 1 5.6 O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
CHEMBL2011865 79986 9 None -25 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 397 2 3 1 5.6 O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1016/j.bmcl.2015.03.049
134131265 148964 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 8 0 5 5.0 Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1 10.1016/j.bmc.2016.12.039
CHEMBL3883995 148964 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 8 0 5 5.0 Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1 10.1016/j.bmc.2016.12.039
44324602 214208 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 293 3 2 3 4.2 Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1 10.1016/s0960-894x(02)00925-3
CHEMBL94056 214208 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 293 3 2 3 4.2 Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1 10.1016/s0960-894x(02)00925-3
44460744 212502 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 363 6 0 4 3.9 CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL82550 212502 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 363 6 0 4 3.9 CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1 10.1016/s0960-894x(02)00438-9
44424669 92499 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 412 6 1 8 0.3 Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
CHEMBL228939 92499 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 412 6 1 8 0.3 Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
168291393 198773 0 None -4 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 338 8 2 3 2.7 NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
CHEMBL5201464 198773 0 None -4 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 338 8 2 3 2.7 NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
155515408 183111 0 None -8 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 491 8 0 3 5.9 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4442062 183111 0 None -8 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 491 8 0 3 5.9 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595453 183111 0 None -8 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 491 8 0 3 5.9 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1 10.1016/j.bmc.2019.06.028
23369450 188351 2 None -72 2 Human 5.7 pKi = 5.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 352 5 1 5 2.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL476822 188351 2 None -72 2 Human 5.7 pKi = 5.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 352 5 1 5 2.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
53377140 73179 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851835 73179 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216729 73179 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2011.04.060
155515890 176781 0 None -5 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 414 8 0 4 4.6 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4442385 176781 0 None -5 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 414 8 0 4 4.6 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
11667626 109361 0 None -11 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 359 10 1 4 2.4 CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
CHEMBL2431042 109361 0 None -11 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 359 10 1 4 2.4 CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
CHEMBL3040827 109361 0 None -11 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 359 10 1 4 2.4 CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O 10.1021/jm400766k
135398745 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2012.07.043
47 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2012.07.043
CHEMBL715 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2012.07.043
DB00334 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2012.07.043
118728512 124485 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 423 8 1 4 5.3 Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401475 124485 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 423 8 1 4 5.3 Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
23151734 110735 0 None -467 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 265 1 2 2 1.3 NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3092758 110735 0 None -467 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 265 1 2 2 1.3 NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2 10.1016/j.bmc.2013.10.010
71602586 96454 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC 10.1016/j.bmc.2013.02.038
CHEMBL2376447 96454 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC 10.1016/j.bmc.2013.02.038
168281784 197726 0 None -30 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 429 8 0 6 4.0 O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5185787 197726 0 None -30 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 429 8 0 6 4.0 O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
11432215 91074 0 None 1 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
CHEMBL221453 91074 0 None 1 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
164619236 192488 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 6 1 5 2.6 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4865591 192488 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 6 1 5 2.6 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
72549767 120849 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 429 8 1 4 4.2 COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326976 120849 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 429 8 1 4 4.2 COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
71602586 96454 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC 10.1016/j.bmc.2013.02.038
CHEMBL2376447 96454 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC 10.1016/j.bmc.2013.02.038
90654696 116859 0 None -35 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 374 7 2 5 1.2 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235733 116859 0 None -35 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 374 7 2 5 1.2 NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2014.03.005
42618257 188375 0 None -11 2 Human 5.7 pKi = 5.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 412 5 0 5 3.9 Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL477066 188375 0 None -11 2 Human 5.7 pKi = 5.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 412 5 0 5 3.9 Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
57400830 75212 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 429 8 0 4 4.5 CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917358 75212 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 429 8 0 4 4.5 CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
164619236 192488 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 6 1 5 2.6 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4865591 192488 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 6 1 5 2.6 O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
162676036 190564 0 None -22 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 410 9 2 5 2.7 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4798934 190564 0 None -22 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 410 9 2 5 2.7 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4804093 190564 0 None -22 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 410 9 2 5 2.7 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1 10.1016/j.ejmech.2020.112437
228 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm9911433
33 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm9911433
6005 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm9911433
CHEMBL53 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm9911433
DB00714 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm9911433
156015087 184319 0 None 1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 406 7 1 4 4.8 C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4640150 184319 0 None 1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 406 7 1 4 4.8 C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
228 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm0108505
33 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm0108505
6005 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm0108505
CHEMBL53 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm0108505
DB00714 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1021/jm0108505
228 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/s0960-894x(00)00655-7
33 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/s0960-894x(00)00655-7
6005 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/s0960-894x(00)00655-7
CHEMBL53 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/s0960-894x(00)00655-7
DB00714 7233 28 None -6 23 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/s0960-894x(00)00655-7
44424668 151151 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 432 5 1 8 0.6 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
CHEMBL390581 151151 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 432 5 1 8 0.6 Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
76336182 112285 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 368 4 0 4 4.3 c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121430 112285 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 368 4 0 4 4.3 c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
127051016 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819642 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819734 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
46205046 131359 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1 nan
CHEMBL3640587 131359 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1 nan
46205046 131359 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1 nan
CHEMBL3640587 131359 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1 nan
46203755 131324 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1 nan
CHEMBL3640554 131324 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1 nan
46205371 131363 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 3 1 2 3.9 COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1 nan
CHEMBL3640591 131363 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 3 1 2 3.9 COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1 nan
11617668 71470 0 None -3 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2005.05.059
CHEMBL181874 71470 0 None -3 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2005.05.059
4806 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2021.128275
7351 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2021.128275
9966051 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2021.128275
CHEMBL2104993 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2021.128275
DB09068 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2021.128275
4806 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
7351 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
9966051 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
CHEMBL2104993 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
DB09068 10780 88 None -8 13 Human 7.7 pKi = 7.7 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1021/jm101459g
11384575 72948 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 418 9 0 5 3.2 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm049743b
CHEMBL184310 72948 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 418 9 0 5 3.2 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm049743b
11373831 131427 0 None -1 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 431 9 0 5 3.2 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm049743b
CHEMBL364124 131427 0 None -1 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 431 9 0 5 3.2 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm049743b
46203755 131324 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1 nan
CHEMBL3640554 131324 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1 nan
46205371 131363 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 3 1 2 3.9 COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1 nan
CHEMBL3640591 131363 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 3 1 2 3.9 COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1 nan
11373831 131427 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 431 9 0 5 3.2 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmc.2011.09.044
CHEMBL364124 131427 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 431 9 0 5 3.2 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmc.2011.09.044
127026750 144455 0 None 14 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3758591 144455 0 None 14 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2015.11.040
118626089 172252 3 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4239823 172252 3 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
118626035 172297 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4240954 172297 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
145983760 172319 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 534 6 0 6 5.6 O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4241497 172319 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 534 6 0 6 5.6 O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
145983390 172698 0 None -6 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 535 6 0 7 5.0 O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4250274 172698 0 None -6 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 535 6 0 7 5.0 O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
134156305 161028 0 None 7 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 510 11 1 5 5.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3986254 161028 0 None 7 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 510 11 1 5 5.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
145993714 174131 0 None 21 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 483 6 2 6 2.7 CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4294549 174131 0 None 21 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 483 6 2 6 2.7 CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
127037681 143392 0 None 7 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 406 8 1 6 2.4 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1 10.1039/C5MD00166H
CHEMBL3739745 143392 0 None 7 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 406 8 1 6 2.4 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1 10.1039/C5MD00166H
127041106 143560 0 None 16 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 440 8 1 6 2.9 Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 10.1039/C5MD00166H
CHEMBL3741281 143560 0 None 16 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 440 8 1 6 2.9 Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 10.1039/C5MD00166H
117209858 191333 1 None -1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4848305 191333 1 None -1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
66800934 118831 0 None -8 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 514 9 1 7 4.1 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289949 118831 0 None -8 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 514 9 1 7 4.1 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
118626089 172252 3 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4239823 172252 3 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
11101733 109609 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 413 5 1 3 4.9 Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL305526 109609 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 413 5 1 3 4.9 Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
10896196 211040 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 484 7 1 4 4.5 CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL71170 211040 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 484 7 1 4 4.5 CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
155555378 181213 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 5 4.7 O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4553199 181213 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 5 4.7 O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
10948529 60933 0 None 54 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 365 6 1 6 3.3 O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL160706 60933 0 None 54 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 365 6 1 6 3.3 O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
46205375 131367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 337 4 1 3 4.3 COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1 nan
CHEMBL3640595 131367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 337 4 1 3 4.3 COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1 nan
46205375 131367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 337 4 1 3 4.3 COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1 nan
CHEMBL3640595 131367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 337 4 1 3 4.3 COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1 nan
162675490 189908 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 503 8 2 7 3.6 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4795056 189908 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 503 8 2 7 3.6 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1 10.1016/j.ejmech.2020.112395
2470 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/s0960-894x(00)00166-9
3300 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/s0960-894x(00)00166-9
5265 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/s0960-894x(00)00166-9
99 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/s0960-894x(00)00166-9
CHEMBL267930 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/s0960-894x(00)00166-9
10552788 25443 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 480 6 0 3 4.3 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1021/jm970519e
CHEMBL12771 25443 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 480 6 0 3 4.3 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1021/jm970519e
10552788 25443 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 480 6 0 3 4.3 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12771 25443 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 480 6 0 3 4.3 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1016/s0960-894x(00)00166-9
44368304 51680 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 479 6 0 3 5.1 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1021/jm030841r
CHEMBL152292 51680 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 479 6 0 3 5.1 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1 10.1021/jm030841r
134138168 154469 0 None -1 10 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL3931889 154469 0 None -1 10 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 275 4 0 2 4.1 COc1ccccc1-c1cc(CN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5094493 222278 0 None 1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
153287541 178974 0 None 10 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 279 1 0 2 3.9 CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C 10.1021/acsmedchemlett.9b00225
CHEMBL4473697 178974 0 None 10 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 279 1 0 2 3.9 CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C 10.1021/acsmedchemlett.9b00225
135398737 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm070516u
38 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm070516u
722 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm070516u
CHEMBL42 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm070516u
DB00363 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm070516u
24865725 194863 0 None -39 12 Human 7.7 pKi = 7.7 Binding
Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor
ChEMBL 453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
CHEMBL497963 194863 0 None -39 12 Human 7.7 pKi = 7.7 Binding
Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor
ChEMBL 453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
2470 10425 50 None -1258 58 Human 7.7 pKi = 7.7 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030841r
3300 10425 50 None -1258 58 Human 7.7 pKi = 7.7 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030841r
5265 10425 50 None -1258 58 Human 7.7 pKi = 7.7 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030841r
99 10425 50 None -1258 58 Human 7.7 pKi = 7.7 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030841r
CHEMBL267930 10425 50 None -1258 58 Human 7.7 pKi = 7.7 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030841r
162668859 190521 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4788452 190521 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803670 190521 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
156020807 184827 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4647184 184827 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
127051016 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819642 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819734 147654 0 None -6 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 386 5 1 4 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
6918542 211703 24 None -537 10 Human 5.7 pKi = 5.7 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL76237 211703 24 None -537 10 Human 5.7 pKi = 5.7 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
122483296 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764934 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765870 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
164623281 192591 0 None -1 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 447 7 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4867109 192591 0 None -1 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 447 7 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
90656704 119462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 381 10 1 4 4.6 CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262435 119462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 381 10 1 4 4.6 CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304198 119462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 381 10 1 4 4.6 CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
122483296 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764934 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765870 144883 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 363 6 0 4 4.2 CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
71450247 89751 0 None -380 9 Human 5.7 pKi = 5.7 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 368 5 0 3 5.5 CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 10.1021/jm300943r
CHEMBL2181188 89751 0 None -380 9 Human 5.7 pKi = 5.7 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 368 5 0 3 5.5 CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 10.1021/jm300943r
127026434 144518 0 None 3 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 9 1 4 4.9 CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759170 144518 0 None 3 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 9 1 4 4.9 CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
76314437 112283 0 None 25 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 443 5 0 3 6.6 c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121418 112283 0 None 25 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 443 5 0 3 6.6 c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1 10.1016/j.ejmech.2014.01.055
155534362 178683 0 None -91 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 522 8 1 6 5.3 COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1 10.1016/j.ejmech.2019.01.031
CHEMBL4469813 178683 0 None -91 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 522 8 1 6 5.3 COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1 10.1016/j.ejmech.2019.01.031
168287508 198310 0 None -48 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 438 9 3 8 3.1 Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5194270 198310 0 None -48 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 438 9 3 8 3.1 Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
156020306 184908 0 None -4 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 602 11 0 6 6.9 O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1 10.1016/j.bmc.2020.115459
CHEMBL4648390 184908 0 None -4 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 602 11 0 6 6.9 O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1 10.1016/j.bmc.2020.115459
42625267 193586 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 348 6 0 2 4.2 O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1 10.1021/jm8014553
CHEMBL489255 193586 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 348 6 0 2 4.2 O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1 10.1021/jm8014553
73213196 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
164622318 192615 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
CHEMBL4867534 192615 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
71455625 89739 0 None -48977 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 353 5 0 4 4.4 CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 10.1021/jm300943r
CHEMBL2181170 89739 0 None -48977 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 353 5 0 4 4.4 CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 10.1021/jm300943r
73213196 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2014.05.016
CHEMBL3104093 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2014.05.016
44517732 202010 0 None 50 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 481 8 3 5 2.9 COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1 10.1016/j.bmcl.2009.06.038
CHEMBL550881 202010 0 None 50 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 481 8 3 5 2.9 COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1 10.1016/j.bmcl.2009.06.038
71727065 109186 0 None -8 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL2401931 109186 0 None -8 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1 10.1016/j.bmcl.2013.05.062
CHEMBL3039720 109186 0 None -8 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 5 0 6 4.3 COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1 10.1016/j.bmcl.2013.05.062
73213196 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -1 13 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
51002362 89397 0 None -3 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 448 5 1 7 3.8 COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1 10.1021/jm300955x
CHEMBL2179222 89397 0 None -3 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 448 5 1 7 3.8 COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1 10.1021/jm300955x
168273001 196991 0 None 3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 403 9 4 7 3.3 COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5174637 196991 0 None 3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 403 9 4 7 3.3 COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
72197845 96619 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2019.111736
CHEMBL2377590 96619 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2019.111736
72197845 96619 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2013.02.033
CHEMBL2377590 96619 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 10.1016/j.ejmech.2013.02.033
127026143 144575 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 1 3 5.3 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759593 144575 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 1 3 5.3 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
155540198 179682 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 406 7 0 4 3.3 O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4516076 179682 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 406 7 0 4 3.3 O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
4790508 14947 4 None -24 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 333 7 2 5 2.0 OC(CNCC1COc2ccccc2O1)COc1ccccc1F 10.1016/j.bmcl.2010.03.012
CHEMBL1091933 14947 4 None -24 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 333 7 2 5 2.0 OC(CNCC1COc2ccccc2O1)COc1ccccc1F 10.1016/j.bmcl.2010.03.012
44424658 92538 0 None -2 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 440 8 0 9 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229180 92538 0 None -2 2 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 440 8 0 9 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
23290944 88601 0 None -131 7 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 392 6 0 4 3.8 O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 10.1016/j.bmcl.2012.05.119
CHEMBL2164350 88601 0 None -131 7 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 392 6 0 4 3.8 O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 10.1016/j.bmcl.2012.05.119
45269494 203445 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 436 7 3 3 3.5 N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1 10.1016/j.bmcl.2009.06.038
CHEMBL564509 203445 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 436 7 3 3 3.5 N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1 10.1016/j.bmcl.2009.06.038
127026146 144552 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 449 7 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759437 144552 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 449 7 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2015.11.040
156018383 184702 0 None -16 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2020.115459
CHEMBL4645308 184702 0 None -16 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2020.115459
53381002 72239 0 None -22 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 240 2 2 4 2.2 COc1cccc2[nH]cc(-c3ccnc(N)n3)c12 10.1016/j.bmc.2011.08.033
CHEMBL1829959 72239 0 None -22 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 240 2 2 4 2.2 COc1cccc2[nH]cc(-c3ccnc(N)n3)c12 10.1016/j.bmc.2011.08.033
164620867 192421 0 None -177 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4864448 192421 0 None -177 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 410 6 1 7 3.4 CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
156018897 184591 0 None -8 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 356 4 1 3 3.6 CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4643640 184591 0 None -8 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 356 4 1 3 3.6 CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3 10.1016/j.bmc.2020.115578
11397459 26129 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12908 26129 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
11259115 26176 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12933 26176 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/s0960-894x(00)00166-9
11453756 26760 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL13032 26760 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
11382534 104881 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 350 6 0 2 4.9 CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL273452 104881 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 350 6 0 2 4.9 CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
49850567 63243 0 None -999 9 Human 6.7 pKi = 6.7 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 452 6 1 6 4.0 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1632217 63243 0 None -999 9 Human 6.7 pKi = 6.7 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 452 6 1 6 4.0 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 10.1021/jm100714c
11397459 26129 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
CHEMBL12908 26129 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
11259115 26176 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
CHEMBL12933 26176 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
11453756 26760 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
CHEMBL13032 26760 0 None -1 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
11382534 104881 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 350 6 0 2 4.9 CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
CHEMBL273452 104881 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 350 6 0 2 4.9 CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
71602690 96462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376459 96462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2013.02.038
153287567 179163 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 292 1 1 2 4.3 Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1 10.1021/acsmedchemlett.9b00225
CHEMBL4476396 179163 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 292 1 1 2 4.3 Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1 10.1021/acsmedchemlett.9b00225
155557042 181336 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 219 1 1 3 1.9 COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2 10.1021/acsmedchemlett.9b00225
CHEMBL4556297 181336 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 219 1 1 3 1.9 COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2 10.1021/acsmedchemlett.9b00225
153287557 182858 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 420 1 1 2 5.2 C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4591108 182858 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 420 1 1 2 5.2 C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
10296414 10304 15 None -158 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 431 6 1 5 4.2 O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C 10.1016/j.bmcl.2006.11.031
76 10304 15 None -158 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 431 6 1 5 4.2 O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C 10.1016/j.bmcl.2006.11.031
CHEMBL183460 10304 15 None -158 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 431 6 1 5 4.2 O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C 10.1016/j.bmcl.2006.11.031
73213195 111236 0 None -7 12 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104092 111236 0 None -7 12 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
164610456 191279 0 None -61 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 328 5 1 7 1.7 CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4847379 191279 0 None -61 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 328 5 1 7 1.7 CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
9891618 113901 0 None -1995 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 486 4 1 6 5.0 Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12 10.1016/s0960-894x(01)00558-3
CHEMBL316081 113901 0 None -1995 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 486 4 1 6 5.0 Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12 10.1016/s0960-894x(01)00558-3
44393088 71787 0 None - 1 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 386 8 3 7 3.4 CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.ejmech.2019.111705
CHEMBL182322 71787 0 None - 1 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 386 8 3 7 3.4 CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.ejmech.2019.111705
44393113 70405 0 None 5 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 358 7 3 7 3.5 CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL180086 70405 0 None 5 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 358 7 3 7 3.5 CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
10475231 72161 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL182937 72161 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
44393161 73470 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 334 8 2 5 4.1 C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL185511 73470 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 334 8 2 5 4.1 C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393045 168438 0 None 9 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 370 7 3 6 3.6 C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL413049 168438 0 None 9 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 370 7 3 6 3.6 C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
107 6929 121 None -3 31 Human 8.7 pKi = 8.7 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030030n
1833 6929 121 None -3 31 Human 8.7 pKi = 8.7 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030030n
CHEMBL8165 6929 121 None -3 31 Human 8.7 pKi = 8.7 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1021/jm030030n
145970078 171590 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 485 7 1 3 5.3 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.7b01898
CHEMBL4218549 171590 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 485 7 1 3 5.3 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.7b01898
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030030n
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030030n
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030030n
10028436 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1021/jm030030n
3237 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1021/jm030030n
CHEMBL95104 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1021/jm030030n
1621 9207 17 None -34 44 Rat 8.7 pKi = 8.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030030n
17 9207 17 None -34 44 Rat 8.7 pKi = 8.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030030n
5761 9207 17 None -34 44 Rat 8.7 pKi = 8.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030030n
CHEMBL263881 9207 17 None -34 44 Rat 8.7 pKi = 8.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030030n
DB04829 9207 17 None -34 44 Rat 8.7 pKi = 8.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030030n
127025242 144580 0 None 70 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759617 144580 0 None 70 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 446 8 1 4 4.3 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1 10.1016/j.ejmech.2015.11.040
71455002 88221 0 None 7 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159489 88221 0 None 7 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
155534839 178777 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 437 6 1 3 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1 10.1016/j.bmcl.2019.126703
CHEMBL4471208 178777 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 437 6 1 3 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1 10.1016/j.bmcl.2019.126703
56944954 164345 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 445 7 3 4 4.0 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4080399 164345 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 445 7 3 4 4.0 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
56944956 165698 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 433 6 2 3 4.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4095555 165698 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 433 6 2 3 4.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
10834268 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1016/j.bmc.2019.06.028
CHEMBL428494 173605 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 10.1016/j.bmc.2019.06.028
10028436 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2018.06.019
3237 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2018.06.019
CHEMBL95104 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.bmcl.2018.06.019
66800909 118847 0 None 4 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 8 3.4 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3289965 118847 0 None 4 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 8 3.4 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
10274894 171969 0 None - 1 Human 8.7 pKi = 8.7 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 438 6 1 2 6.0 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
CHEMBL422869 171969 0 None - 1 Human 8.7 pKi = 8.7 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 438 6 1 2 6.0 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
44266182 214103 0 None 23 2 Human 8.7 pKi = 8.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 407 4 0 5 3.3 O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9347 214103 0 None 23 2 Human 8.7 pKi = 8.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 407 4 0 5 3.3 O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
24854368 166597 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 377 7 1 3 4.3 CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL410628 166597 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 377 7 1 3 4.3 CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00438-9
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00438-9
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00438-9
5 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00726
5202 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00726
CHEMBL39 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00726
DB08839 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/acs.jmedchem.1c00726
11633354 102755 0 None 52 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
CHEMBL259550 102755 0 None 52 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
11633354 102755 0 None 52 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
CHEMBL259550 102755 0 None 52 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
5 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2016.06.080
5202 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2016.06.080
CHEMBL39 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2016.06.080
DB08839 6927 72 None -3 53 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmcl.2016.06.080
439280 126797 107 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1016/j.bmcl.2015.02.042
6971044 126797 107 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1016/j.bmcl.2015.02.042
CHEMBL350221 126797 107 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1016/j.bmcl.2015.02.042
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2019.111705
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2019.111705
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2019.111705
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00842-9
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00842-9
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/s0960-894x(02)00842-9
10500557 23452 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/j.bmcl.2009.12.027
CHEMBL12427 23452 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/j.bmcl.2009.12.027
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm0104264
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm0104264
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm0104264
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm980519u
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm980519u
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm980519u
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmc.2011.12.039
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmc.2011.12.039
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmc.2011.12.039
44276598 102458 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1016/j.bmcl.2010.03.012
CHEMBL25815 102458 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1016/j.bmcl.2010.03.012
9845006 25011 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm070279v
CHEMBL12702 25011 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm070279v
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/acs.jmedchem.7b01898
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/acs.jmedchem.7b01898
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/acs.jmedchem.7b01898
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2018.06.019
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2018.06.019
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2018.06.019
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2014.08.023
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2014.08.023
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.ejmech.2014.08.023
141745657 179156 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 394 5 1 4 4.7 Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1 10.1016/j.bmcl.2019.126703
CHEMBL4476294 179156 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 394 5 1 4 4.7 Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1 10.1016/j.bmcl.2019.126703
4106 9280 22 None -4 33 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2019.07.046
5358812 9280 22 None -4 33 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2019.07.046
89 9280 22 None -4 33 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2019.07.046
CHEMBL93240 9280 22 None -4 33 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmc.2019.07.046
44437327 97642 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 650 15 0 8 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239231 97642 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 650 15 0 8 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
9888494 104947 0 None 1 13 Human 8.7 pKi = 8.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 422 4 1 5 3.6 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL273921 104947 0 None 1 13 Human 8.7 pKi = 8.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 422 4 1 5 3.6 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
9888494 104947 0 None -1 13 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 422 4 1 5 3.6 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 10.1021/jm0498102
CHEMBL273921 104947 0 None -1 13 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 422 4 1 5 3.6 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 10.1021/jm0498102
118706734 127304 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 309 2 3 2 1.9 CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
CHEMBL3310714 127304 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 309 2 3 2 1.9 CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
CHEMBL3545444 127304 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 309 2 3 2 1.9 CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
145993474 174096 0 None 10 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 417 5 1 2 5.5 Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1 10.1016/j.ejmech.2017.12.063
CHEMBL4294077 174096 0 None 10 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 417 5 1 2 5.5 Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1 10.1016/j.ejmech.2017.12.063
10862697 211164 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1 10.1021/jm0104264
CHEMBL71847 211164 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1 10.1021/jm0104264
44327688 119441 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 375 5 1 3 3.4 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL330353 119441 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 375 5 1 3 3.4 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/s0960-894x(02)00690-x
44327688 119441 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 5 1 3 3.4 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1021/jm030030n
CHEMBL330353 119441 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 5 1 3 3.4 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1021/jm030030n
16006605 104768 3 None 2 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 229 0 2 3 2.6 CC1NC(N)=Nc2c(Cl)ccc(Cl)c21 10.1016/j.bmcl.2007.10.080
CHEMBL272781 104768 3 None 2 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 229 0 2 3 2.6 CC1NC(N)=Nc2c(Cl)ccc(Cl)c21 10.1016/j.bmcl.2007.10.080
135966709 161934 4 None 10 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 233 2 2 4 2.3 CNC1=Nc2c(OC(C)C)cccc2C(C)N1 10.1016/j.bmcl.2007.10.080
CHEMBL402179 161934 4 None 10 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 233 2 2 4 2.3 CNC1=Nc2c(OC(C)C)cccc2C(C)N1 10.1016/j.bmcl.2007.10.080
24825775 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
3929 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
CHEMBL4205349 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1016/j.ejmech.2019.111705
24825775 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
3929 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
CHEMBL4205349 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.7b01898
4376990 199788 5 None 1 11 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 372 4 2 4 4.1 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
CHEMBL5207529 199788 5 None 1 11 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 372 4 2 4 4.1 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
CHEMBL5222754 199788 5 None 1 11 Human 8.6 pKi = 8.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 372 4 2 4 4.1 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
24825775 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.2c00633
3929 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.2c00633
CHEMBL4205349 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1021/acs.jmedchem.2c00633
CHEMBL5074190 221093 0 None 29 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
24825775 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
3929 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
CHEMBL4205349 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
ChEMBL 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 10.1039/C8MD00313K
16093485 161842 0 None 1 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 239 1 2 4 2.3 COc1cc(Cl)c(C)c2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
CHEMBL401745 161842 0 None 1 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 239 1 2 4 2.3 COc1cc(Cl)c(C)c2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
44266315 105161 0 None 30 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 410 5 0 3 4.3 O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL275343 105161 0 None 30 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 410 5 0 3 4.3 O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL5074190 221093 0 None 29 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(CCN(C)C)ccc1Cl 10.1021/acs.jmedchem.1c00110
11153905 72380 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2 10.1016/j.bmc.2010.01.035
CHEMBL183329 72380 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2 10.1016/j.bmc.2010.01.035
24854369 102975 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL260762 102975 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
10064052 131047 0 None 93 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 311 4 0 3 3.8 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2 10.1021/jm0498102
CHEMBL363466 131047 0 None 93 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 311 4 0 3 3.8 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2 10.1021/jm0498102
10064052 131047 0 None 93 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor
ChEMBL 311 4 0 3 3.8 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2 10.1021/jm0498102
CHEMBL363466 131047 0 None 93 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor
ChEMBL 311 4 0 3 3.8 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2 10.1021/jm0498102
22001618 88588 10 None 1 3 Human 8.6 pKi = 8.6 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1016/j.ejmech.2019.111705
CHEMBL2164336 88588 10 None 1 3 Human 8.6 pKi = 8.6 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1016/j.ejmech.2019.111705
22001618 88588 10 None -1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1016/j.bmc.2013.06.020
CHEMBL2164336 88588 10 None -1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1016/j.bmc.2013.06.020
11545363 197277 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant
ChEMBL 379 7 1 4 3.7 COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1 10.1021/acs.jmedchem.2c00633
CHEMBL5179267 197277 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant
ChEMBL 379 7 1 4 3.7 COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1 10.1021/acs.jmedchem.2c00633
168269899 196856 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 461 8 0 5 3.6 COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5172635 196856 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 461 8 0 5 3.6 COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.2c00633
22001618 88588 10 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL2164336 88588 10 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
66801018 118869 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 502 8 1 7 4.4 Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3289986 118869 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 502 8 1 7 4.4 Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
145991864 173784 0 None 5 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4288120 173784 0 None 5 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 449 6 1 2 6.0 Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.ejmech.2017.12.063
153287566 177959 0 None 74 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 278 1 0 2 4.0 CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C 10.1021/acsmedchemlett.9b00225
CHEMBL4459009 177959 0 None 74 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 278 1 0 2 4.0 CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C 10.1021/acsmedchemlett.9b00225
23133427 88584 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 256 2 1 2 2.9 Fc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL2164332 88584 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 256 2 1 2 2.9 Fc1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
118709756 120324 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321798 120324 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
11772153 73647 0 None 3 3 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
CHEMBL186316 73647 0 None 3 3 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
44437335 158436 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 722 16 0 11 5.0 COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396396 158436 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 722 16 0 11 5.0 COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
44266222 215149 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 387 4 0 3 4.4 O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9952 215149 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 387 4 0 3 4.4 O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL5077293 221270 0 None 1 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
162666034 189090 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 419 7 1 5 3.5 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2020.112149
CHEMBL4784228 189090 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 419 7 1 5 3.5 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2020.112149
CHEMBL5077293 221270 0 None 1 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCNC2)ccc1Cl 10.1021/acs.jmedchem.1c00110
CHEMBL5094234 222352 0 None 2 8 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096019 222352 0 None 2 8 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
11697659 102630 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
CHEMBL259010 102630 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
11697659 102630 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
CHEMBL259010 102630 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm070279v
CHEMBL5091373 222346 0 None 1 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095981 222346 0 None 1 9 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
118713593 121156 0 None 26 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 338 5 0 4 3.9 O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1 10.1016/j.ejmech.2014.08.023
CHEMBL3331262 121156 0 None 26 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 338 5 0 4 3.9 O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1 10.1016/j.ejmech.2014.08.023
90656683 117752 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 375 6 1 4 4.2 CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262408 117752 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 375 6 1 4 4.2 CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
118713684 121166 0 None -6 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 425 9 0 6 4.5 COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331387 121166 0 None -6 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 425 9 0 6 4.5 COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
11186985 130624 0 None -11 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2010.01.035
CHEMBL362540 130624 0 None -11 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2010.01.035
11267988 73603 0 None -2 4 Rat 8.5 pKi = 8.5 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 309 6 0 2 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1 10.1021/jm0498102
CHEMBL186112 73603 0 None -2 4 Rat 8.5 pKi = 8.5 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 309 6 0 2 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1 10.1021/jm0498102
10430685 61073 0 None 64 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 8 1 6 4.1 O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL160817 61073 0 None 64 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 8 1 6 4.1 O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
118713682 121164 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 395 8 0 5 4.4 O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331385 121164 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 395 8 0 5 4.4 O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
118728530 124504 0 None -2 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 454 9 0 7 4.5 CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401493 124504 0 None -2 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 454 9 0 7 4.5 CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1 10.1016/j.bmcl.2015.02.042
42388639 194833 0 None -4 5 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 439 8 1 5 3.3 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmcl.2009.06.038
CHEMBL497749 194833 0 None -4 5 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 439 8 1 5 3.3 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1016/j.bmcl.2009.06.038
90656685 117751 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 325 6 1 4 3.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262407 117751 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 325 6 1 4 3.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
2470 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
3300 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
5265 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
99 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL267930 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL5094493 222278 0 None 1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
76336181 113176 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 433 4 1 4 5.8 Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121425 113176 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 433 4 1 4 5.8 Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139444 113176 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 433 4 1 4 5.8 Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
76318013 113177 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 435 4 0 3 6.0 FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121427 113177 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 435 4 0 3 6.0 FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139445 113177 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 435 4 0 3 6.0 FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
127026452 144451 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 8 1 4 5.0 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3758569 144451 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 8 1 4 5.0 O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2015.11.040
127024949 144574 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 442 8 1 4 4.0 O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759581 144574 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 442 8 1 4 4.0 O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2015.11.040
71454997 88186 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 490 9 1 5 5.1 O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159455 88186 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 490 9 1 5 5.1 O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
145947405 174450 0 None 5 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 472 7 2 6 2.3 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4159967 174450 0 None 5 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 472 7 2 6 2.3 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4301968 174450 0 None 5 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 472 7 2 6 2.3 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
138691316 181467 0 None 61 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 289 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(Br)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4559312 181467 0 None 61 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 289 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(Br)cc12 10.1016/j.ejmech.2019.03.017
59752638 189176 0 None -1 4 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 253 2 1 3 2.6 c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4785470 189176 0 None -1 4 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 253 2 1 3 2.6 c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
11732538 211080 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 419 7 1 4 4.2 COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1016/j.bmc.2019.06.028
CHEMBL71390 211080 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 419 7 1 4 4.2 COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1016/j.bmc.2019.06.028
90656685 117751 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 325 6 1 4 3.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262407 117751 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 325 6 1 4 3.0 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
118713595 121158 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 5 4.1 O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331264 121158 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 5 4.1 O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
44439392 98557 0 None 4677 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 336 5 2 2 5.1 CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
CHEMBL241100 98557 0 None 4677 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 336 5 2 2 5.1 CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
66801613 118827 0 None -2 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 7 1 6 4.1 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289945 118827 0 None -2 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 7 1 6 4.1 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
122178709 128153 0 None 2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 381 6 0 5 4.0 C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581254 128153 0 None 2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 381 6 0 5 4.0 C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
16573 184398 34 None 8 6 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 341 3 1 5 3.2 COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL464099 184398 34 None 8 6 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 341 3 1 5 3.2 COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
11341035 151120 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
CHEMBL390558 151120 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
42618265 189447 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 378 8 1 4 3.7 O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL478905 189447 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 378 8 1 4 3.7 O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
44266229 214497 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 364 5 0 3 3.6 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9564 214497 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 364 5 0 3 3.6 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1 10.1016/s0960-894x(03)00077-5
14566720 108672 11 None -6 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 242 2 1 3 2.3 COc1ccc2cccc(N3CCNCC3)c2c1 10.1021/jm030826m
CHEMBL300824 108672 11 None -6 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 242 2 1 3 2.3 COc1ccc2cccc(N3CCNCC3)c2c1 10.1021/jm030826m
11732538 211080 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1021/jm0104264
CHEMBL71390 211080 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1021/jm0104264
11725453 105856 0 None 1 6 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030030n
CHEMBL28056 105856 0 None 1 6 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030030n
90656669 117766 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 8 1 4 3.8 CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262422 117766 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 8 1 4 3.8 CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
11725453 105856 0 None -1 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
CHEMBL28056 105856 0 None -1 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
11397459 26129 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
CHEMBL12908 26129 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 479 9 0 5 4.7 COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
11259115 26176 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL12933 26176 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 435 7 0 4 4.3 O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2019.06.028
11453756 26760 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
CHEMBL13032 26760 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 451 7 0 5 4.0 COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
127040443 143487 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 382 9 1 4 3.2 CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1 10.1039/C5MD00166H
CHEMBL3740624 143487 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 382 9 1 4 3.2 CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1 10.1039/C5MD00166H
44439408 97990 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 426 4 0 5 4.9 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL240024 97990 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 426 4 0 5 4.9 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2 10.1016/j.bmcl.2007.01.093
44439396 98586 0 None 7 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 348 3 0 3 4.3 CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL241281 98586 0 None 7 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 348 3 0 3 4.3 CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
66800926 118868 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 488 7 1 7 4.0 Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3289985 118868 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 488 7 1 7 4.0 Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL5284727 201038 0 None -8 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 615 9 0 8 5.0 O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2023.117256
2872937 124706 6 None -2 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 464 4 1 5 4.7 O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403332 124706 6 None -2 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 464 4 1 5 4.7 O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1 10.1016/j.bmcl.2015.03.049
127026145 144482 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 399 7 2 3 4.6 CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3758814 144482 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 399 7 2 3 4.6 CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL5275394 200631 0 None -10 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 601 9 0 8 4.6 O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2023.117256
156010319 183821 0 None -3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115459
CHEMBL4632519 183821 0 None -3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115459
145978420 170780 0 None 2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4208306 170780 0 None 2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
155546190 183264 0 None -2 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 467 8 0 4 4.9 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4530770 183264 0 None -2 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 467 8 0 4 4.9 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4596654 183264 0 None -2 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 467 8 0 4 4.9 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
42626291 199492 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 363 7 0 3 3.6 O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
CHEMBL521973 199492 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 363 7 0 3 3.6 O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
71462154 88138 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 396 9 1 4 4.1 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159311 88138 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 396 9 1 4 4.1 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1 10.1016/j.ejmech.2012.07.043
145977555 170421 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br 10.1021/acs.jmedchem.8b00828
CHEMBL4204033 170421 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br 10.1021/acs.jmedchem.8b00828
CHEMBL5092755 222166 0 None -120 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None Cc1ccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)cc1C 10.1021/acs.jmedchem.1c00497
5249591 176056 1 None -257 2 Rat 5.7 pKi = 5.7 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 419 4 0 5 3.4 COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL441313 176056 1 None -257 2 Rat 5.7 pKi = 5.7 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 419 4 0 5 3.4 COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1 10.1016/j.bmcl.2004.09.029
135398745 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2018.01.002
47 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2018.01.002
CHEMBL715 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2018.01.002
DB00334 9688 112 None -95 65 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1016/j.ejmech.2018.01.002
155566191 182518 0 None -67 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4583082 182518 0 None -67 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
57390694 77241 0 None -9 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 385 5 0 4 5.1 Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
CHEMBL1946255 77241 0 None -9 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 385 5 0 4 5.1 Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
53323186 63787 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1 10.1016/j.bmcl.2010.11.078
CHEMBL1644273 63787 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1 10.1016/j.bmcl.2010.11.078
155563452 182088 0 None -40 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 361 6 0 4 3.7 O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4573441 182088 0 None -40 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 361 6 0 4 3.7 O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
57396417 78322 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1949975 78322 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1963009 78322 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 484 5 0 5 4.1 O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
44209472 76947 2 None -114 11 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
CHEMBL1940420 76947 2 None -114 11 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
134144304 161272 0 None -2 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3952251 161272 0 None -2 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3990525 161272 0 None -2 9 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.4 O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
155563452 182088 0 None -40 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 361 6 0 4 3.7 O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4573441 182088 0 None -40 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 361 6 0 4 3.7 O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
752521 205516 8 None -102 9 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 295 1 3 5 1.9 CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 10.1021/acs.jmedchem.5b01631
CHEMBL582877 205516 8 None -102 9 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 295 1 3 5 1.9 CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 10.1021/acs.jmedchem.5b01631
145990093 173781 0 None 9 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 440 7 2 5 1.8 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4288077 173781 0 None 9 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 440 7 2 5 1.8 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O 10.1039/C8MD00168E
137649997 164068 0 None 3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 464 6 0 5 3.8 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4076903 164068 0 None 3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 464 6 0 5 3.8 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmc.2017.04.046
145992305 173778 0 None 5 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 371 5 2 6 0.4 CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4288040 173778 0 None 5 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 371 5 2 6 0.4 CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
46205369 131361 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 3 1 2 4.0 Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C nan
CHEMBL3640589 131361 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 3 1 2 4.0 Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C nan
46206019 131377 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1ccccc1-c1ccccc1C1CCNC1 nan
CHEMBL3640605 131377 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1ccccc1-c1ccccc1C1CCNC1 nan
46205369 131361 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 3 1 2 4.0 Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C nan
CHEMBL3640589 131361 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 3 1 2 4.0 Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C nan
46206019 131377 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1ccccc1-c1ccccc1C1CCNC1 nan
CHEMBL3640605 131377 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1ccccc1-c1ccccc1C1CCNC1 nan
155537074 179049 0 None -147 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12 10.1016/j.ejmech.2019.111857
CHEMBL4474618 179049 0 None -147 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12 10.1016/j.ejmech.2019.111857
46203751 131321 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1 nan
CHEMBL3640551 131321 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1 nan
44388858 68271 0 None -2 4 Rat 7.7 pKi = 7.7 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2005.05.059
CHEMBL177064 68271 0 None -2 4 Rat 7.7 pKi = 7.7 Binding
Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2005.05.059
44388858 68271 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL177064 68271 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.ejmech.2014.01.055
76320704 110315 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 1 0 2 5.2 CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm049743b
CHEMBL3085300 110315 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 1 0 2 5.2 CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm049743b
2726 7706 68 None -13 72 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm030030n
621 7706 68 None -13 72 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm030030n
83 7706 68 None -13 72 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm030030n
CHEMBL71 7706 68 None -13 72 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm030030n
DB00477 7706 68 None -13 72 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm030030n
68788 214386 14 None -1 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 348 3 2 3 1.3 CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
CHEMBL95067 214386 14 None -1 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 348 3 2 3 1.3 CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
46203751 131321 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1 nan
CHEMBL3640551 131321 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1 nan
145975720 170739 0 None 2 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 394 4 1 4 2.5 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4207835 170739 0 None 2 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 394 4 1 4 2.5 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
134151118 158980 0 None 3 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 498 12 1 4 5.4 CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3968569 158980 0 None 3 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 498 12 1 4 5.4 CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
71453278 88199 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 7 1 3 4.5 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F 10.1016/j.ejmech.2012.07.043
CHEMBL2159467 88199 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 7 1 3 4.5 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F 10.1016/j.ejmech.2012.07.043
135398737 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2022.114193
38 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2022.114193
722 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2022.114193
CHEMBL42 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2022.114193
DB00363 7745 93 None -13 90 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2022.114193
71574204 93042 0 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 10.1016/j.ejmech.2012.11.042
CHEMBL2312640 93042 0 None -2 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 10.1016/j.ejmech.2012.11.042
155557443 181423 0 None 9 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 245 2 1 3 2.7 COc1ccc2[nH]cc(-c3cncn3C)c2c1F 10.1016/j.ejmech.2019.03.017
CHEMBL4558202 181423 0 None 9 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 245 2 1 3 2.7 COc1ccc2[nH]cc(-c3cncn3C)c2c1F 10.1016/j.ejmech.2019.03.017
127037682 143371 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 453 8 1 5 4.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1 10.1039/C5MD00166H
CHEMBL3739561 143371 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 453 8 1 5 4.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1 10.1039/C5MD00166H
42618269 97762 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 397 6 0 4 3.1 O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
CHEMBL239680 97762 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 397 6 0 4 3.1 O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
24854109 168065 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 397 6 1 3 4.5 CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL412143 168065 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 397 6 1 3 4.5 CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
136180317 124489 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 4 3.7 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401479 124489 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 4 3.7 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL5082182 221572 1 None -4 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(Cl)c1 10.1021/acs.jmedchem.1c00497
44324403 213664 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 265 2 2 3 3.3 Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
CHEMBL90752 213664 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 265 2 2 3 3.3 Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
11811833 109846 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 418 7 1 3 5.0 COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL307352 109846 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 418 7 1 3 5.0 COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL5077755 221292 0 None -12 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(Cl)c(Cl)c1 10.1021/acs.jmedchem.1c00497
57401515 75173 0 None -32 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 498 8 0 5 4.0 COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL1916745 75173 0 None -32 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 498 8 0 5 4.0 COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
44582676 196558 0 None -1 17 Human 6.7 pKi = 6.7 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 403 9 0 4 4.3 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL516088 196558 0 None -1 17 Human 6.7 pKi = 6.7 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 403 9 0 4 4.3 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
11373934 91454 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
CHEMBL222507 91454 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
CHEMBL5283557 200996 0 None -2 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 484 6 0 5 4.8 O=C1CC2CCc3ccsc3C2=NN1Cc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1 10.1016/j.bmc.2023.117256
60165537 82126 0 None -1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 308 5 0 3 4.6 c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2 10.1016/j.ejmech.2012.03.042
CHEMBL2037523 82126 0 None -1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 308 5 0 3 4.6 c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2 10.1016/j.ejmech.2012.03.042
73213195 111236 0 None -7 12 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104092 111236 0 None -7 12 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
22065997 106131 0 None -64 4 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 310 3 1 3 3.0 Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 10.1016/s0960-894x(01)00241-4
CHEMBL282424 106131 0 None -64 4 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 310 3 1 3 3.0 Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 10.1016/s0960-894x(01)00241-4
145964694 170816 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 450 9 2 5 3.1 CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4208791 170816 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 450 9 2 5 3.1 CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
145947301 174443 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4160262 174443 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4301925 174443 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1 10.1016/j.ejmech.2018.01.093
145976787 170405 0 None 20 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 428 7 1 4 3.5 O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4203823 170405 0 None 20 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 428 7 1 4 3.5 O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
118728529 124503 0 None -8 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 0 6 4.7 Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401492 124503 0 None -8 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 0 6 4.7 Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
155564110 182148 0 None -23 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 375 6 0 4 4.0 O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4574793 182148 0 None -23 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 375 6 0 4 4.0 O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
122483297 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763670 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765839 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
155564110 182148 0 None -23 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 375 6 0 4 4.0 O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4574793 182148 0 None -23 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 375 6 0 4 4.0 O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
22330705 124720 8 None -1 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 438 3 0 3 5.5 Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12 10.1016/j.bmcl.2015.03.049
CHEMBL3403345 124720 8 None -1 4 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 438 3 0 3 5.5 Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12 10.1016/j.bmcl.2015.03.049
25107650 194064 0 None -23 3 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 10 1 3 4.8 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
CHEMBL492872 194064 0 None -23 3 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 10 1 3 4.8 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
122483297 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763670 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765839 144869 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 320 5 0 3 4.7 O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
155569568 182973 0 None -32 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 380 7 2 3 5.4 COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4593671 182973 0 None -32 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 380 7 2 3 5.4 COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
145990459 173741 0 None 2 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 490 7 2 5 2.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4287320 173741 0 None 2 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 490 7 2 5 2.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O 10.1039/C8MD00168E
71602689 96461 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376458 96461 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2013.02.038
162669595 189523 0 None -24 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 489 7 1 6 5.0 Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 10.1016/j.ejmech.2020.112149
CHEMBL4790020 189523 0 None -24 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 489 7 1 6 5.0 Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 10.1016/j.ejmech.2020.112149
71602689 96461 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376458 96461 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2013.02.038
71456780 88194 0 None -7 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 426 8 1 4 3.5 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159462 88194 0 None -7 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 426 8 1 4 3.5 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1 10.1016/j.ejmech.2012.07.043
44374225 61520 0 None 54 3 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 244 4 0 4 3.1 CN(C)CCSc1nc(C(C)(C)C)cs1 10.1016/j.bmcl.2003.11.050
CHEMBL161203 61520 0 None 54 3 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 244 4 0 4 3.1 CN(C)CCSc1nc(C(C)(C)C)cs1 10.1016/j.bmcl.2003.11.050
90654687 116885 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 475 8 1 6 2.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235759 116885 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 475 8 1 6 2.9 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
145986031 172601 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 0 6 5.2 O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4248544 172601 0 None -1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 0 6 5.2 O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
118731361 124975 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 558 10 0 4 5.8 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409044 124975 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 558 10 0 4 5.8 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
139488527 176312 0 None 42 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 272 3 2 3 2.3 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4435235 176312 0 None 42 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 272 3 2 3 2.3 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12 10.1016/j.ejmech.2019.03.017
56660668 183879 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 301 2 0 1 4.9 CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2019.115262
CHEMBL4633326 183879 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 301 2 0 1 4.9 CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2019.115262
155561978 182605 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 518 8 1 6 4.1 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4584900 182605 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 518 8 1 6 4.1 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
42625445 193557 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 399 6 0 3 4.3 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL489028 193557 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 399 6 0 3 4.3 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.08.023
21963826 83526 5 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 398 7 0 4 4.0 O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL206747 83526 5 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 398 7 0 4 4.0 O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1 10.1016/j.bmcl.2005.11.067
118711997 120859 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2014.07.026
CHEMBL3326986 120859 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2014.07.026
122178707 128151 0 None 1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 395 6 0 5 4.3 COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581252 128151 0 None 1 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 395 6 0 5 4.3 COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
25107649 194036 0 None -1 3 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 411 10 1 4 4.4 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
CHEMBL492691 194036 0 None -1 3 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 411 10 1 4 4.4 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
142601333 192542 0 None 36 6 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4866412 192542 0 None 36 6 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
127051592 147656 0 None 1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818710 147656 0 None 1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819742 147656 0 None 1 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
44340897 16483 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 377 5 1 4 2.9 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL113192 16483 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 377 5 1 4 2.9 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1 10.1016/s0960-894x(02)00690-x
164609650 191776 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 389 4 0 4 4.0 O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4854456 191776 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 389 4 0 4 4.0 O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
164611932 191981 0 None -5 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 364 6 1 4 3.1 O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4857597 191981 0 None -5 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 364 6 1 4 3.1 O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
127051592 147656 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818710 147656 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819742 147656 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 317 5 0 2 3.4 [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
71602690 96462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376459 96462 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2013.02.038
53323185 63782 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 288 3 1 2 3.8 c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644268 63782 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 288 3 1 2 3.8 c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1 10.1016/j.bmcl.2010.11.078
44439397 97987 0 None 22 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 4 0 5 4.7 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL240021 97987 0 None 22 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 4 0 5 4.7 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2 10.1016/j.bmcl.2007.01.093
11453751 97735 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 451 3 0 4 4.3 CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1 10.1016/j.bmc.2007.07.029
CHEMBL239467 97735 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 451 3 0 4 4.3 CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1 10.1016/j.bmc.2007.07.029
13069655 127385 0 None -18 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 412 6 0 9 0.7 COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3360992 127385 0 None -18 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 412 6 0 9 0.7 COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3546106 127385 0 None -18 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 412 6 0 9 0.7 COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
164608999 191163 0 None -18 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 310 6 1 4 2.8 Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4845741 191163 0 None -18 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 310 6 1 4 2.8 Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
71451454 88187 0 None -2 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 398 8 1 5 3.0 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159456 88187 0 None -2 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 398 8 1 5 3.0 O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
71460456 88145 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 382 6 1 3 3.6 O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159318 88145 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 382 6 1 3 3.6 O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
127028152 144983 0 None 12 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 426 6 2 5 1.8 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3769836 144983 0 None 12 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 426 6 2 5 1.8 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
90654681 116879 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 454 7 1 4 3.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235753 116879 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 454 7 1 4 3.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.03.005
11133795 210553 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 431 7 2 3 3.9 NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL68094 210553 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 431 7 2 3 3.9 NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
117209864 192813 1 None 1 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4870675 192813 1 None 1 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
164617626 192239 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 324 6 1 5 2.4 Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4861794 192239 0 None -9 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 324 6 1 5 2.4 Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
57402588 75201 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917347 75201 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
145992567 173555 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 548 8 2 5 4.4 CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4283960 173555 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 548 8 2 5 4.4 CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
25107519 194448 0 None -17 3 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 395 10 1 4 3.7 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
CHEMBL495120 194448 0 None -17 3 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 395 10 1 4 3.7 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 10.1021/jm800615e
46233349 207078 5 None -2 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 244 4 0 3 1.8 CN(C)CCOc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
CHEMBL597356 207078 5 None -2 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 244 4 0 3 1.8 CN(C)CCOc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
129103318 174093 0 None -309 13 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting
ChEMBL 475 7 0 5 5.0 O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 10.1021/acs.jmedchem.8b01096
CHEMBL4293999 174093 0 None -309 13 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting
ChEMBL 475 7 0 5 5.0 O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 10.1021/acs.jmedchem.8b01096
117209864 192813 1 None 1 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4870675 192813 1 None 1 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
90656698 119385 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 366 9 1 3 5.3 CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262431 119385 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 366 9 1 3 5.3 CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3302234 119385 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 366 9 1 3 5.3 CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
43840296 157083 2 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 227 4 1 2 3.1 CNCc1cccc(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3952849 157083 2 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 227 4 1 2 3.1 CNCc1cccc(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
3303 9024 46 None -338 15 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1016/s0960-894x(01)00241-4
5311200 9024 46 None -338 15 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1016/s0960-894x(01)00241-4
CHEMBL267014 9024 46 None -338 15 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1016/s0960-894x(01)00241-4
46205045 131358 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 392 6 1 3 4.2 CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640586 131358 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 392 6 1 3 4.2 CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
46205045 131358 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 392 6 1 3 4.2 CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640586 131358 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 392 6 1 3 4.2 CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
57395598 75200 0 None 1 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917346 75200 0 None 1 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
145976722 170768 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br 10.1021/acs.jmedchem.8b00828
CHEMBL4208165 170768 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br 10.1021/acs.jmedchem.8b00828
136180319 124491 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 376 7 1 4 3.5 O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
CHEMBL3401481 124491 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 376 7 1 4 3.5 O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12 10.1016/j.bmcl.2015.02.042
60165418 82124 0 None -281 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 6 0 6 3.2 c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.ejmech.2012.03.042
CHEMBL2037521 82124 0 None -281 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 6 0 6 3.2 c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.ejmech.2012.03.042
851853 198097 13 None -3 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 239 1 1 2 1.5 NC(=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
CHEMBL5191370 198097 13 None -3 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 239 1 1 2 1.5 NC(=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
53320865 63796 0 None - 1 Rat 4.6 pKi = 4.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2 10.1016/j.bmcl.2010.11.078
CHEMBL1644484 63796 0 None - 1 Rat 4.6 pKi = 4.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2 10.1016/j.bmcl.2010.11.078
11341394 91447 0 None 2 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 448 9 2 4 3.7 NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222489 91447 0 None 2 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 448 9 2 4 3.7 NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
168290928 198635 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.3 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5199182 198635 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.3 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
162650168 186885 0 None -389 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 455 7 1 6 4.3 Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4748379 186885 0 None -389 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 455 7 1 6 4.3 Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 10.1016/j.ejmech.2020.112149
162651619 187090 0 None -288 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 475 7 1 6 4.7 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4751063 187090 0 None -288 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 475 7 1 6 4.7 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 10.1016/j.ejmech.2020.112149
44393052 72047 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 378 9 2 7 3.6 C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL182840 72047 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 378 9 2 7 3.6 C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
58405183 117474 0 None -4 4 Rat 7.6 pKi = 7.6 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 339 6 1 3 3.9 FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1 10.1021/ml500082j
CHEMBL3260336 117474 0 None -4 4 Rat 7.6 pKi = 7.6 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 339 6 1 3 3.9 FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1 10.1021/ml500082j
209 9831 97 None -31 23 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1021/jm030030n
2113 9831 97 None -31 23 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1021/jm030030n
4748 9831 97 None -31 23 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1021/jm030030n
CHEMBL567 9831 97 None -31 23 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1021/jm030030n
DB00850 9831 97 None -31 23 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1021/jm030030n
44460725 112418 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 325 3 0 3 3.3 CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL312489 112418 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 325 3 0 3 3.3 CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1 10.1016/s0960-894x(02)00438-9
118626045 172447 0 None -4 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4244691 172447 0 None -4 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
145947359 174434 0 None 9 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 463 7 2 7 1.5 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4171652 174434 0 None 9 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 463 7 2 7 1.5 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4301757 174434 0 None 9 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 463 7 2 7 1.5 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
60196074 88591 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 239 2 1 3 2.2 c1ccc(-c2ccccc2N2CCNCC2)nc1 10.1021/jm3003679
CHEMBL2164340 88591 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 239 2 1 3 2.2 c1ccc(-c2ccccc2N2CCNCC2)nc1 10.1021/jm3003679
155537788 179130 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 436 6 1 6 4.4 O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4475894 179130 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 436 6 1 6 4.4 O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
117209965 192026 1 None 3 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4858338 192026 1 None 3 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
142601333 192542 0 None 36 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4866412 192542 0 None 36 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
164609650 191776 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 389 4 0 4 4.0 O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4854456 191776 0 None 1 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 389 4 0 4 4.0 O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
10593348 104070 0 None 4 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
CHEMBL26907 104070 0 None 4 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
134134210 150563 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 255 4 0 2 3.7 COc1ccccc1-c1cc(CN(C)C)ccc1C 10.1016/j.ejmech.2016.07.029
CHEMBL3901042 150563 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 255 4 0 2 3.7 COc1ccccc1-c1cc(CN(C)C)ccc1C 10.1016/j.ejmech.2016.07.029
68281136 118832 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 422 7 1 7 2.8 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3289950 118832 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 422 7 1 7 2.8 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
122178710 128154 0 None 3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 431 6 0 5 5.0 COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581255 128154 0 None 3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 431 6 0 5 5.0 COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
135458410 173968 0 None -4 6 Human 7.6 pKi = 7.6 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL429136 173968 0 None -4 6 Human 7.6 pKi = 7.6 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
117209965 192026 1 None 3 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4858338 192026 1 None 3 6 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
153287542 176313 0 None 6 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 265 1 1 2 3.6 C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4435237 176313 0 None 6 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 265 1 1 2 3.6 C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
109026957 178615 2 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 394 6 0 6 1.3 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4468683 178615 2 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 394 6 0 6 1.3 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2016.06.080
132547276 148938 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 446 11 0 6 4.9 CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3883640 148938 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 446 11 0 6 4.9 CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1 10.1016/j.bmc.2016.12.039
71061756 99894 0 None 38 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442997 99894 0 None 38 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmc.2014.01.016
71061756 99894 0 None 38 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442997 99894 0 None 38 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1 10.1016/j.bmcl.2013.09.025
162666163 189160 0 None 22 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 532 10 0 6 6.7 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4785158 189160 0 None 22 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 532 10 0 6 6.7 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
11825129 55546 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1 10.1021/jm020994z
CHEMBL155861 55546 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1 10.1021/jm020994z
71061659 99895 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL2442998 99895 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmc.2014.01.016
71061659 99895 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
CHEMBL2442998 99895 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
ChEMBL 474 11 1 6 3.6 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1 10.1016/j.bmcl.2013.09.025
11059148 210692 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 434 7 1 5 4.1 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3 10.1021/jm0104264
CHEMBL69040 210692 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 434 7 1 5 4.1 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3 10.1021/jm0104264
118736365 125715 0 None -32 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 465 7 1 10 1.4 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423329 125715 0 None -32 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 465 7 1 10 1.4 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
2232766 168150 7 None -42 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 297 7 0 2 4.9 c1ccc2c(OCCCCCN3CCCCC3)cccc2c1 10.1016/j.bmc.2018.04.023
CHEMBL4126145 168150 7 None -42 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 297 7 0 2 4.9 c1ccc2c(OCCCCCN3CCCCC3)cccc2c1 10.1016/j.bmc.2018.04.023
155561581 182419 0 None -9 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 364 4 1 6 -0.3 CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4580959 182419 0 None -9 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 364 4 1 6 -0.3 CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
122483222 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764889 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765872 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
127028154 145035 0 None 7 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 444 6 2 5 1.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770473 145035 0 None 7 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 444 6 2 5 1.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O 10.1016/j.ejmech.2016.02.024
168295269 199291 0 None -12 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 463 7 0 8 3.3 COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1 10.1016/j.ejmech.2022.114218
CHEMBL5209272 199291 0 None -12 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 463 7 0 8 3.3 COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1 10.1016/j.ejmech.2022.114218
162653993 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4753809 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4802865 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
122483222 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764889 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765872 144885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 391 6 0 4 4.2 CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
57390336 75194 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 10 1 4 2.9 NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917340 75194 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 10 1 4 2.9 NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
155514378 176629 0 None -588 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12 10.1021/acsmedchemlett.6b00056
CHEMBL4440130 176629 0 None -588 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12 10.1021/acsmedchemlett.6b00056
155559092 181568 0 None -7 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 446 5 0 4 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4561846 181568 0 None -7 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 446 5 0 4 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
71451456 88195 0 None -31 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 8 1 4 3.5 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159463 88195 0 None -31 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 8 1 4 3.5 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1 10.1016/j.ejmech.2012.07.043
59757163 113119 0 None -218 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 251 1 2 1 1.7 NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3092760 113119 0 None -218 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 251 1 2 1 1.7 NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2 10.1016/j.bmc.2013.10.010
CHEMBL3139189 113119 0 None -218 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 251 1 2 1 1.7 NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2 10.1016/j.bmc.2013.10.010
145985289 172486 0 None -3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 534 6 0 6 5.6 O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4245607 172486 0 None -3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 534 6 0 6 5.6 O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
127037680 143671 0 None 19 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 442 8 1 5 4.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1 10.1039/C5MD00166H
CHEMBL3742257 143671 0 None 19 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 442 8 1 5 4.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1 10.1039/C5MD00166H
66801429 166506 0 None 2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 443 6 2 3 4.5 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4104596 166506 0 None 2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 443 6 2 3 4.5 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
44408813 81798 0 None 29 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 381 8 0 5 3.3 CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1 10.1016/j.bmcl.2005.11.067
CHEMBL203400 81798 0 None 29 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 381 8 0 5 3.3 CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1 10.1016/j.bmcl.2005.11.067
118709740 120309 0 None 23 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 348 7 0 2 4.2 O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321778 120309 0 None 23 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 348 7 0 2 4.2 O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1 10.1021/jm500880c
122178700 128083 0 None 2 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 411 8 0 5 5.0 CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3580670 128083 0 None 2 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 411 8 0 5 5.0 CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
122178705 128149 0 None -2 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 411 7 0 5 5.0 CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581250 128149 0 None -2 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 411 7 0 5 5.0 CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
11384146 208512 0 None -60 9 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 10.1021/jm049243i
CHEMBL606556 208512 0 None -60 9 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 10.1021/jm049243i
155566508 182583 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 422 7 0 5 2.6 COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4584464 182583 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 422 7 0 5 2.6 COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2016.06.080
164611932 191981 0 None -5 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 364 6 1 4 3.1 O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4857597 191981 0 None -5 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 364 6 1 4 3.1 O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
9996500 25141 1 None -10 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 326 6 0 4 3.1 COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1 10.1021/acs.jmedchem.7b01898
CHEMBL1271151 25141 1 None -10 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 326 6 0 4 3.1 COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1 10.1021/acs.jmedchem.7b01898
136152964 201718 0 None -8 8 Human 7.6 pKi = 7.6 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 259 2 2 3 2.8 C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL541993 201718 0 None -8 8 Human 7.6 pKi = 7.6 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 259 2 2 3 2.8 C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
118524964 184914 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 243 2 0 1 3.8 CN(C)C1CCc2c(cccc2C2CCCC2)C1 10.1016/j.bmc.2019.115262
CHEMBL4648489 184914 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 243 2 0 1 3.8 CN(C)C1CCc2c(cccc2C2CCCC2)C1 10.1016/j.bmc.2019.115262
66801561 162856 0 None -794 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4062817 162856 0 None -794 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
9856041 30886 3 None -6606 8 Human 4.6 pKi = 4.6 Binding
Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand
ChEMBL 230 2 2 2 2.4 CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 10.1021/jm030205t
CHEMBL133868 30886 3 None -6606 8 Human 4.6 pKi = 4.6 Binding
Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand
ChEMBL 230 2 2 2 2.4 CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 10.1021/jm030205t
60165545 82130 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 336 6 0 4 4.7 O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037527 82130 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 336 6 0 4 4.7 O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
90656707 117770 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 400 7 1 3 5.3 CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262426 117770 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 400 7 1 3 5.3 CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
168292233 198639 0 None -34 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 8 0 6 4.2 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5199228 198639 0 None -34 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 8 0 6 4.2 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
1346 6871 117 None -147 9 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm3003679
280 6871 117 None -147 9 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm3003679
9899402 6871 117 None -147 9 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm3003679
CHEMBL9666 6871 117 None -147 9 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 10.1021/jm3003679
42618263 189268 1 None -9 2 Human 6.6 pKi = 6.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 336 5 1 4 2.5 O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL478682 189268 1 None -9 2 Human 6.6 pKi = 6.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 336 5 1 4 2.5 O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
155534184 178721 0 None -162 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 514 7 1 5 5.3 O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
CHEMBL4470437 178721 0 None -162 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 514 7 1 5 5.3 O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 10.1016/j.ejmech.2019.07.027
71457690 90573 0 None -2 5 Human 5.6 pKi = 5.6 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 280 3 1 3 1.4 OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1 10.1016/j.bmcl.2012.08.046
CHEMBL2205817 90573 0 None -2 5 Human 5.6 pKi = 5.6 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 280 3 1 3 1.4 OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1 10.1016/j.bmcl.2012.08.046
145965668 170893 0 None 1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4209807 170893 0 None 1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2 10.1016/j.bmcl.2018.06.019
162650396 186864 0 None -12 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 469 7 1 5 4.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4748107 186864 0 None -12 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 469 7 1 5 4.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1 10.1016/j.ejmech.2020.112149
155542237 179869 0 None -117 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 472 7 2 6 5.2 COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
CHEMBL4520003 179869 0 None -117 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 472 7 2 6 5.2 COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
155514576 183329 0 None -245 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 338 3 2 5 2.9 Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1 10.1016/j.ejmech.2019.06.001
CHEMBL4441060 183329 0 None -245 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 338 3 2 5 2.9 Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1 10.1016/j.ejmech.2019.06.001
CHEMBL4597227 183329 0 None -245 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 338 3 2 5 2.9 Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1 10.1016/j.ejmech.2019.06.001
60165543 82122 0 None -47 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 367 6 0 7 2.9 O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037519 82122 0 None -47 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 367 6 0 7 2.9 O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
4407909 199645 1 None -4 10 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 356 4 2 4 3.6 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
CHEMBL5182943 199645 1 None -4 10 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 356 4 2 4 3.6 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
CHEMBL5221893 199645 1 None -4 10 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 356 4 2 4 3.6 COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC 10.1021/acsmedchemlett.1c00694
58404615 131334 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1 nan
CHEMBL3640563 131334 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1 nan
58404615 131334 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1 nan
CHEMBL3640563 131334 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1 nan
CHEMBL5084249 221684 0 None -3 8 Human 7.6 pKi = 7.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
134144864 157467 0 None 6 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 600 15 1 7 5.1 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3955917 157467 0 None 6 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 600 15 1 7 5.1 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
155540807 179295 0 None -3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1 10.1016/j.ejmech.2019.111736
CHEMBL4483554 179295 0 None -3 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1 10.1016/j.ejmech.2019.111736
2756712 88583 87 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 238 2 1 2 2.8 c1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
CHEMBL2164331 88583 87 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 238 2 1 2 2.8 c1ccc(-c2cccc(N3CCNCC3)c2)cc1 10.1021/jm3003679
135398737 7745 93 None -13 90 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2014.01.065
38 7745 93 None -13 90 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2014.01.065
722 7745 93 None -13 90 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2014.01.065
CHEMBL42 7745 93 None -13 90 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2014.01.065
DB00363 7745 93 None -13 90 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2014.01.065
155517162 176920 0 None -16 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 432 6 1 2 6.4 Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.bmcl.2019.126769
CHEMBL4444213 176920 0 None -16 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 432 6 1 2 6.4 Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.bmcl.2019.126769
134154069 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3970299 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3990113 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
57395086 78328 0 None 2 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12 10.1016/j.bmc.2011.12.039
CHEMBL1949966 78328 0 None 2 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12 10.1016/j.bmc.2011.12.039
CHEMBL1963029 78328 0 None 2 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12 10.1016/j.bmc.2011.12.039
2220 9908 82 None -3 14 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1016/j.bmc.2013.10.010
27400 9908 82 None -3 14 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1016/j.bmc.2013.10.010
93 9908 82 None -3 14 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1016/j.bmc.2013.10.010
CHEMBL294951 9908 82 None -3 14 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1016/j.bmc.2013.10.010
DB06153 9908 82 None -3 14 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1016/j.bmc.2013.10.010
11582132 72785 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
CHEMBL1836860 72785 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
66800823 118843 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 504 7 1 7 4.4 Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3289961 118843 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 504 7 1 7 4.4 Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
23661594 97400 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 664 16 0 8 6.3 COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL238808 97400 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 664 16 0 8 6.3 COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
162670445 189653 0 None 10 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 460 10 0 6 5.2 COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4791805 189653 0 None 10 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 460 10 0 6 5.2 COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
44266267 214573 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 363 5 0 3 4.8 O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9615 214573 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 363 5 0 3 4.8 O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1 10.1016/s0960-894x(03)00077-5
49850672 63160 0 None -100 9 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 404 5 1 5 4.1 COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
CHEMBL1631532 63160 0 None -100 9 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 404 5 1 5 4.1 COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
11729084 210975 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 400 6 0 2 5.2 CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32 10.1021/jm0104264
CHEMBL70819 210975 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 400 6 0 2 5.2 CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32 10.1021/jm0104264
10593348 104070 0 None 4 4 Rat 7.6 pKi = 7.6 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
CHEMBL26907 104070 0 None 4 4 Rat 7.6 pKi = 7.6 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
CHEMBL5084249 221684 0 None -3 8 Human 7.6 pKi = 7.6 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
117209962 191648 1 None 4 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4852622 191648 1 None 4 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
134154069 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3970299 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3990113 161226 0 None -1 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 10.1016/j.bmc.2016.09.019
162654406 187359 0 None -63 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 459 7 1 6 4.2 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4754193 187359 0 None -63 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 459 7 1 6 4.2 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 10.1016/j.ejmech.2020.112149
179 7188 115 None -9 50 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1021/jm070516u
2159 7188 115 None -9 50 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1021/jm070516u
963 7188 115 None -9 50 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1021/jm070516u
CHEMBL243712 7188 115 None -9 50 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1021/jm070516u
DB06288 7188 115 None -9 50 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1021/jm070516u
168293874 198958 0 None -5 11 Human 7.6 pKi = 7.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 312 2 3 3 3.3 COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 10.1021/acsmedchemlett.1c00694
CHEMBL5204071 198958 0 None -5 11 Human 7.6 pKi = 7.6 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 312 2 3 3 3.3 COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 10.1021/acsmedchemlett.1c00694
24854186 102556 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL258593 102556 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
24768520 99782 0 None -1 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL244161 99782 0 None -1 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
46204422 131340 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 293 3 1 2 3.7 FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640569 131340 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 293 3 1 2 3.7 FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1 nan
46204422 131340 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 293 3 1 2 3.7 FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640569 131340 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 293 3 1 2 3.7 FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1 nan
134134456 150122 0 None 20 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 514 11 1 5 5.4 COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3897426 150122 0 None 20 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 514 11 1 5 5.4 COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
44341130 16420 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 377 5 1 5 2.2 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL112765 16420 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 377 5 1 5 2.2 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1 10.1016/s0960-894x(02)00690-x
162674732 190164 0 None 48 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 534 9 1 7 5.2 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4797980 190164 0 None 48 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 534 9 1 7 5.2 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
162651486 187048 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 437 7 1 5 3.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 10.1016/j.ejmech.2020.112149
CHEMBL4750587 187048 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 437 7 1 5 3.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 10.1016/j.ejmech.2020.112149
10805599 105992 0 None -13 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 319 3 0 2 4.4 CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL281554 105992 0 None -13 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 319 3 0 2 4.4 CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
72550865 120857 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326984 120857 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2014.07.026
53318219 63801 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 350 4 0 2 5.2 CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
CHEMBL1644489 63801 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 350 4 0 2 5.2 CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
42625356 193778 0 None -21 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 397 5 0 3 4.1 O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
CHEMBL490644 193778 0 None -21 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 397 5 0 3 4.1 O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
66801267 118862 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 7 1 6 4.1 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3289979 118862 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 7 1 6 4.1 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
42618259 196513 0 None -13 2 Human 5.6 pKi = 5.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 442 6 0 6 3.9 COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1 10.1016/j.bmcl.2009.02.008
CHEMBL515783 196513 0 None -13 2 Human 5.6 pKi = 5.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 442 6 0 6 3.9 COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1 10.1016/j.bmcl.2009.02.008
44439401 98558 0 None -12 3 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 395 4 0 5 3.6 COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL241101 98558 0 None -12 3 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 395 4 0 5 3.6 COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
11294248 174516 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
CHEMBL430280 174516 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmc.2019.06.028
44401243 175273 0 None -104 9 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.6 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL435301 175273 0 None -104 9 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.6 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 10.1021/jm049632c
11294248 174516 0 None -1 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL430280 174516 0 None -1 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/s0960-894x(00)00166-9
11294248 174516 0 None -1 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
CHEMBL430280 174516 0 None -1 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 465 8 0 5 4.4 COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1021/jm030841r
168283304 198064 0 None -7 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 433 6 0 7 3.3 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5190746 198064 0 None -7 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 433 6 0 7 3.3 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
142601323 192620 0 None 9 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4867560 192620 0 None 9 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
122483235 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763329 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765849 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
9890119 214836 0 None -2511 7 Human 5.6 pKi = 5.6 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 452 4 2 5 4.3 O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1 10.1016/s0960-894x(01)00558-3
CHEMBL97596 214836 0 None -2511 7 Human 5.6 pKi = 5.6 Binding
Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand
ChEMBL 452 4 2 5 4.3 O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1 10.1016/s0960-894x(01)00558-3
6918647 107522 2 None -501 14 Human 5.6 pKi = 5.6 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 10.1021/jm980532e
CHEMBL292759 107522 2 None -501 14 Human 5.6 pKi = 5.6 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 10.1021/jm980532e
155534795 183030 0 None -316 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 402 3 2 5 4.3 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4471055 183030 0 None -316 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 402 3 2 5 4.3 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4594879 183030 0 None -316 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 402 3 2 5 4.3 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2019.06.001
155534575 178725 0 None -12 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 429 8 0 7 2.0 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4470487 178725 0 None -12 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 429 8 0 7 2.0 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2021.128028
142601323 192620 0 None 9 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4867560 192620 0 None 9 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1ccccc1-c1n[nH]cc1N1CCCNCC1 10.1021/acs.jmedchem.1c01093
122483235 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763329 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765849 144879 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 438 8 0 3 7.0 O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
90656675 117750 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 297 5 2 4 2.6 Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262404 117750 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 297 5 2 4 2.6 Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
44437333 98529 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 791 25 0 8 9.8 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL240944 98529 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 791 25 0 8 9.8 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
1296368 57595 16 None -1 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 458 5 2 5 6.0 O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1 10.1016/j.bmcl.2015.03.049
CHEMBL1576791 57595 16 None -1 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 458 5 2 5 6.0 O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1 10.1016/j.bmcl.2015.03.049
134152583 159956 0 None 10 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 530 10 1 5 4.8 O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3976948 159956 0 None 10 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 530 10 1 5 4.8 O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
162670926 190532 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.7 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4790694 190532 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.7 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803789 190532 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.7 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
18133518 171490 1 None 14 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4217334 171490 1 None 14 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
168284840 198075 0 None -8 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 439 5 0 6 3.8 O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5190996 198075 0 None -8 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 439 5 0 6 3.8 O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
134141355 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3924565 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3991357 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
134141355 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3924565 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3991357 161364 0 None -2 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 327 5 0 2 4.8 O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.09.019
44324603 118250 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 252 2 2 4 2.4 Cc1c(NC2=NCCN2)cccc1-c1cccnc1 10.1016/s0960-894x(02)00925-3
CHEMBL327654 118250 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 252 2 2 4 2.4 Cc1c(NC2=NCCN2)cccc1-c1cccnc1 10.1016/s0960-894x(02)00925-3
145965401 170825 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I 10.1021/acs.jmedchem.8b00828
CHEMBL4208911 170825 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I 10.1021/acs.jmedchem.8b00828
44437332 98361 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 763 23 0 8 9.0 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL240729 98361 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 763 23 0 8 9.0 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
134142259 152363 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 501 13 2 5 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3915374 152363 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 501 13 2 5 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1 10.1016/j.ejmech.2016.05.005
127027387 144620 0 None 15 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 451 8 2 5 3.8 Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2015.11.040
CHEMBL3759948 144620 0 None 15 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 451 8 2 5 3.8 Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2015.11.040
242 7258 124 None -15 51 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2012.11.042
34 7258 124 None -15 51 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2012.11.042
60795 7258 124 None -15 51 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2012.11.042
CHEMBL1112 7258 124 None -15 51 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2012.11.042
DB01238 7258 124 None -15 51 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2012.11.042
25125376 184755 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4646015 184755 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1 10.1016/j.bmc.2019.115262
4806 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126703
4806 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126769
7351 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126703
7351 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126769
9966051 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126703
9966051 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126769
CHEMBL2104993 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126703
CHEMBL2104993 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126769
DB09068 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126703
DB09068 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2019.126769
54598063 161336 0 None -37 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL3979261 161336 0 None -37 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL3991129 161336 0 None -37 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method
ChEMBL 354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1 10.1016/j.bmcl.2018.04.059
4806 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2017.11.007
7351 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2017.11.007
9966051 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2017.11.007
CHEMBL2104993 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2017.11.007
DB09068 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.bmcl.2017.11.007
21048761 147084 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 397 7 0 3 5.0 O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL380613 147084 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 397 7 0 3 5.0 O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1 10.1016/j.bmcl.2005.11.067
424430 114406 5 None 60 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 292 3 2 2 3.6 COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL319005 114406 5 None 60 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 292 3 2 2 3.6 COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
46233352 207435 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 248 5 0 4 3.0 CN(C)CCSc1cccc(-c2ccoc2)n1 10.1016/j.bmc.2010.01.035
CHEMBL599612 207435 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 248 5 0 4 3.0 CN(C)CCSc1cccc(-c2ccoc2)n1 10.1016/j.bmc.2010.01.035
4806 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.ejmech.2017.12.063
7351 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.ejmech.2017.12.063
9966051 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.ejmech.2017.12.063
CHEMBL2104993 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.ejmech.2017.12.063
DB09068 10780 88 None -8 13 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 10.1016/j.ejmech.2017.12.063
23369421 188256 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 380 7 1 5 2.9 COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL476463 188256 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 380 7 1 5 2.9 COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
71061750 111791 0 None 23 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 473 11 1 6 4.2 COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113603 111791 0 None 23 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 473 11 1 6 4.2 COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
72548115 120862 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326989 120862 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2014.07.026
109027017 181179 2 None 10 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 378 5 0 4 2.5 O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4552394 181179 2 None 10 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 378 5 0 4 2.5 O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL5080305 221456 0 None -4 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None Cc1cccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)c1 10.1021/acs.jmedchem.1c00497
44324573 118306 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 285 2 2 3 3.7 Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1 10.1016/s0960-894x(02)00925-3
CHEMBL327906 118306 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 285 2 2 3 3.7 Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1 10.1016/s0960-894x(02)00925-3
10521887 121147 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 351 6 0 5 3.2 O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331254 121147 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 351 6 0 5 3.2 O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
162672029 189684 0 None 18 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 534 8 1 7 5.0 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4792307 189684 0 None 18 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 534 8 1 7 5.0 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1 10.1016/j.ejmech.2020.112395
11047201 58899 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1 10.1021/jm020994z
CHEMBL158770 58899 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1 10.1021/jm020994z
127051015 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818128 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819731 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
162673636 190552 0 None -3 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 11 1 4 5.5 CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4796041 190552 0 None -3 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 11 1 4 5.5 CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4803955 190552 0 None -3 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 11 1 4 5.5 CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
276 10286 50 None -100 13 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.bmcl.2007.11.045
5312149 10286 50 None -100 13 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.bmcl.2007.11.045
CHEMBL431298 10286 50 None -100 13 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.bmcl.2007.11.045
156010187 183893 0 None 2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 241 2 0 2 3.4 CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1 10.1016/j.bmc.2019.115262
CHEMBL4633600 183893 0 None 2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 241 2 0 2 3.4 CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1 10.1016/j.bmc.2019.115262
20923078 124713 6 None -1 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 387 4 2 5 3.2 O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1 10.1016/j.bmcl.2015.03.049
CHEMBL3403339 124713 6 None -1 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 387 4 2 5 3.2 O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1 10.1016/j.bmcl.2015.03.049
1353 8692 93 None -120 85 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm030030n
3559 8692 93 None -120 85 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm030030n
86 8692 93 None -120 85 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm030030n
CHEMBL54 8692 93 None -120 85 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm030030n
DB00502 8692 93 None -120 85 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm030030n
52952422 69366 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 391 5 1 5 4.4 N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782809 69366 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 391 5 1 5 4.4 N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
11329844 91934 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
CHEMBL225171 91934 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1 10.1021/jm049702f
127026144 144464 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 415 7 2 3 5.1 CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3758684 144464 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 415 7 2 3 5.1 CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1 10.1016/j.ejmech.2015.11.040
1830 9368 44 None -30 28 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1021/jm030030n
207 9368 44 None -30 28 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1021/jm030030n
23897 9368 44 None -30 28 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1021/jm030030n
CHEMBL460 9368 44 None -30 28 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1021/jm030030n
DB01618 9368 44 None -30 28 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1021/jm030030n
134151428 161331 0 None -10 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 3 0 2 3.5 O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3978642 161331 0 None -10 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 3 0 2 3.5 O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
CHEMBL3991094 161331 0 None -10 9 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 3 0 2 3.5 O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 10.1016/j.bmc.2016.09.019
5216959 15382 4 None -7 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 363 8 2 5 2.6 OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl 10.1016/j.bmcl.2010.03.012
CHEMBL1094908 15382 4 None -7 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 363 8 2 5 2.6 OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl 10.1016/j.bmcl.2010.03.012
1816 9318 102 None -165 18 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1021/jm049632c
4205 9318 102 None -165 18 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1021/jm049632c
7241 9318 102 None -165 18 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1021/jm049632c
CHEMBL654 9318 102 None -165 18 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1021/jm049632c
DB00370 9318 102 None -165 18 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1021/jm049632c
155562202 182597 0 None -26 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 471 9 0 5 4.8 COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4584719 182597 0 None -26 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 471 9 0 5 4.8 COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.bmcl.2019.06.029
888311 207461 46 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 243 4 0 2 2.4 CN(C)CCOc1ccccc1Br 10.1016/j.bmc.2010.01.035
CHEMBL599818 207461 46 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 243 4 0 2 2.4 CN(C)CCOc1ccccc1Br 10.1016/j.bmc.2010.01.035
22549784 124715 6 None -2 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 418 4 0 4 4.9 COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1 10.1016/j.bmcl.2015.03.049
CHEMBL3403340 124715 6 None -2 4 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 418 4 0 4 4.9 COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1 10.1016/j.bmcl.2015.03.049
57393876 75192 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 373 8 1 4 2.1 NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917338 75192 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 373 8 1 4 2.1 NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
155536631 178999 0 None -6 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 339 4 0 3 3.5 Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 10.1016/j.bmc.2020.115943
CHEMBL4474014 178999 0 None -6 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 339 4 0 3 3.5 Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 10.1016/j.bmc.2020.115943
162653993 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4753809 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL4802865 190447 0 None -15 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 10.1016/j.bmc.2020.115943
44424657 92536 0 None 1 2 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 474 8 0 9 2.1 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229179 92536 0 None 1 2 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 474 8 0 9 2.1 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
42618262 188350 0 None -7 2 Human 6.6 pKi = 6.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 486 9 0 7 4.4 COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
CHEMBL476821 188350 0 None -7 2 Human 6.6 pKi = 6.6 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 486 9 0 7 4.4 COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
164619936 192988 0 None -446 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 415 7 0 7 1.6 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4873100 192988 0 None -446 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 415 7 0 7 1.6 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2021.128028
71462064 87937 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 3 5.2 Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158028 87937 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 3 5.2 Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1 10.1016/j.ejmech.2012.07.043
10740969 105862 0 None -3 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 7 1 5 3.4 COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
CHEMBL28063 105862 0 None -3 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 7 1 5 3.4 COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
155536631 178999 0 None -6 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 339 4 0 3 3.5 Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 10.1016/j.bmc.2020.115943
CHEMBL4474014 178999 0 None -6 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 339 4 0 3 3.5 Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 10.1016/j.bmc.2020.115943
452533 126792 5 None 3 3 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 265 5 0 5 2.9 CN(C)CCSc1nc(-c2ccncc2)cs1 10.1016/j.bmcl.2003.11.050
CHEMBL350166 126792 5 None 3 3 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 265 5 0 5 2.9 CN(C)CCSc1nc(-c2ccncc2)cs1 10.1016/j.bmcl.2003.11.050
122181252 128634 0 None -2 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 452 6 1 4 3.6 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3589978 128634 0 None -2 3 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 452 6 1 4 3.6 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
76325349 113194 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 383 4 1 4 4.7 Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121436 113194 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 383 4 1 4 4.7 Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139519 113194 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 383 4 1 4 4.7 Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
127026120 144584 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 9 1 5 3.4 CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759651 144584 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 436 9 1 5 3.4 CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
134131976 151753 0 None 34 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 509 10 1 5 5.2 N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3910730 151753 0 None 34 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 509 10 1 5 5.2 N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
71449549 87942 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 476 11 1 6 3.9 COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2158033 87942 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 476 11 1 6 3.9 COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1 10.1016/j.ejmech.2012.07.043
71462179 88204 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 5 3.1 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159472 88204 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 5 3.1 O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1 10.1016/j.ejmech.2012.07.043
71574304 93040 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12 10.1016/j.ejmech.2012.11.042
CHEMBL2312638 93040 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12 10.1016/j.ejmech.2012.11.042
117209962 191648 1 None 4 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4852622 191648 1 None 4 7 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.8 Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
156020705 184856 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 328 2 1 3 2.8 CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4647589 184856 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 328 2 1 3 2.8 CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3 10.1016/j.bmc.2020.115578
2726 7706 68 None -13 72 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2011.08.033
621 7706 68 None -13 72 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2011.08.033
83 7706 68 None -13 72 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2011.08.033
CHEMBL71 7706 68 None -13 72 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2011.08.033
DB00477 7706 68 None -13 72 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmc.2011.08.033
127051015 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818128 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819731 147652 0 None 5 9 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 283 5 0 1 4.2 Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
9865858 170084 0 None -16 8 Rat 7.6 pKi = 7.6 Binding
The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor
ChEMBL 402 6 1 5 4.0 COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1 10.1021/jm9910122
CHEMBL418854 170084 0 None -16 8 Rat 7.6 pKi = 7.6 Binding
The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor
ChEMBL 402 6 1 5 4.0 COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1 10.1021/jm9910122
10355252 21804 0 None 2 3 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 260 0 0 2 3.5 CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL120927 21804 0 None 2 3 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 260 0 0 2 3.5 CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
44266253 104934 1 None 35 2 Human 7.6 pKi = 7.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 405 4 0 5 3.3 O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL273821 104934 1 None 35 2 Human 7.6 pKi = 7.6 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 405 4 0 5 3.3 O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
44324325 113934 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 281 3 2 4 3.0 COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1 10.1016/s0960-894x(02)00925-3
CHEMBL316283 113934 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 281 3 2 4 3.0 COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1 10.1016/s0960-894x(02)00925-3
10683945 104820 0 None 6 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 277 0 1 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O 10.1021/jm9911433
CHEMBL27309 104820 0 None 6 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 277 0 1 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O 10.1021/jm9911433
155558563 181538 0 None -13 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 402 6 1 5 3.8 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
CHEMBL4561000 181538 0 None -13 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 402 6 1 5 3.8 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
23111951 75188 10 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 330 6 1 3 2.4 O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917334 75188 10 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 330 6 1 3 2.4 O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
68281137 118857 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 9 1 7 3.6 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289974 118857 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 9 1 7 3.6 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
168284109 197526 0 None -151 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 420 7 0 7 2.3 COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1 10.1016/j.ejmech.2022.114193
CHEMBL5182877 197526 0 None -151 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 420 7 0 7 2.3 COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1 10.1016/j.ejmech.2022.114193
44408998 147170 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 321 6 0 3 3.6 O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL380863 147170 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 321 6 0 3 3.6 O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1 10.1016/j.bmcl.2005.11.067
44439402 176157 0 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 292 2 1 2 3.4 OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL442093 176157 0 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 292 2 1 2 3.4 OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 10.1016/j.bmcl.2007.01.093
168279047 197964 0 None -269 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 437 8 0 8 2.7 O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5189101 197964 0 None -269 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 437 8 0 8 2.7 O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
53323187 63792 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 306 3 1 2 4.0 Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 10.1016/j.bmcl.2010.11.078
CHEMBL1644278 63792 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 306 3 1 2 4.0 Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 10.1016/j.bmcl.2010.11.078
58405225 117476 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 323 6 1 6 2.8 CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1 10.1021/ml500082j
CHEMBL3260338 117476 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 323 6 1 6 2.8 CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1 10.1021/ml500082j
155538144 179175 0 None 12 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 295 3 1 3 4.0 CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4476520 179175 0 None 12 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 295 3 1 3 4.0 CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12 10.1016/j.ejmech.2019.03.017
164617626 192239 0 None -9 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 324 6 1 5 2.4 Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4861794 192239 0 None -9 7 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 324 6 1 5 2.4 Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
155565813 182587 0 None -1380 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 350 6 3 3 4.6 Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4584504 182587 0 None -1380 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 350 6 3 3 4.6 Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1 10.1016/j.ejmech.2019.111857
145975992 170295 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 393 4 1 3 3.6 O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4202520 170295 0 None -1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 393 4 1 3 3.6 O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
164608999 191163 0 None -18 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 310 6 1 4 2.8 Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4845741 191163 0 None -18 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 310 6 1 4 2.8 Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
71602640 96457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2376450 96457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
52952424 69369 0 None - 1 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 360 5 1 5 3.1 OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12 10.1021/jm2000773
CHEMBL1782812 69369 0 None - 1 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 360 5 1 5 3.1 OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12 10.1021/jm2000773
45268647 203024 0 None 64 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 414 7 3 3 3.1 Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
CHEMBL561750 203024 0 None 64 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 414 7 3 3 3.1 Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1 10.1016/j.bmcl.2009.06.038
71449627 88134 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 4 4.7 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
CHEMBL2159307 88134 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 4 4.7 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1 10.1016/j.ejmech.2012.07.043
53377238 73148 0 None -45 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851686 73148 0 None -45 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216945 73148 0 None -45 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
134131283 148922 0 None -11 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 390 8 0 5 4.3 Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1 10.1016/j.bmc.2016.12.039
CHEMBL3883517 148922 0 None -11 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 390 8 0 5 4.3 Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1 10.1016/j.bmc.2016.12.039
71602640 96457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2376450 96457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 342 4 0 2 5.0 Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
155552311 180820 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 446 5 0 4 3.9 O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4543646 180820 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 446 5 0 4 3.9 O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
155539605 179624 0 None -12 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay
ChEMBL 313 1 0 4 2.1 CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O 10.1016/j.ejmech.2018.12.048
CHEMBL4514672 179624 0 None -12 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay
ChEMBL 313 1 0 4 2.1 CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O 10.1016/j.ejmech.2018.12.048
168291617 198814 0 None -17 5 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 413 8 0 6 3.5 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5202054 198814 0 None -17 5 Human 6.6 pKi = 6.6 Binding
Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant
ChEMBL 413 8 0 6 3.5 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
24768525 150699 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 406 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL390213 150699 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 406 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21 10.1021/jm070487n
145961372 168386 0 None -128 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 311 7 0 2 5.3 c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1 10.1016/j.bmc.2018.04.023
CHEMBL4129589 168386 0 None -128 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr
ChEMBL 311 7 0 2 5.3 c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1 10.1016/j.bmc.2018.04.023
90654688 116886 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 489 9 1 6 3.3 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235760 116886 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 489 9 1 6 3.3 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
127042540 143901 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 10 0 4 4.9 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747744 143901 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 10 0 4 4.9 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
71449645 88222 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159490 88222 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
25125375 184615 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 281 3 0 2 3.8 COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1 10.1016/j.bmc.2019.115262
CHEMBL4644005 184615 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 281 3 0 2 3.8 COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1 10.1016/j.bmc.2019.115262
127040761 143603 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 438 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1 10.1039/C5MD00166H
CHEMBL3741657 143603 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 438 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1 10.1039/C5MD00166H
24873384 189380 0 None -1 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 255 2 1 3 2.8 CC(C)n1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4788223 189380 0 None -1 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 255 2 1 3 2.8 CC(C)n1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
118709739 120308 0 None 18 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 334 6 0 2 3.8 O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321777 120308 0 None 18 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 334 6 0 2 3.8 O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1 10.1021/jm500880c
122178703 128147 0 None 1 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 383 5 0 5 4.3 COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581248 128147 0 None 1 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 383 5 0 5 4.3 COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
162646653 186281 0 None -18 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 419 7 1 5 3.5 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2020.112149
CHEMBL4741142 186281 0 None -18 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 419 7 1 5 3.5 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 10.1016/j.ejmech.2020.112149
44324536 213621 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 269 2 2 3 3.2 Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1 10.1016/s0960-894x(02)00925-3
CHEMBL90538 213621 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 269 2 2 3 3.2 Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1 10.1016/s0960-894x(02)00925-3
11785077 91942 0 None 1 2 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
CHEMBL225252 91942 0 None 1 2 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
44437332 98361 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 763 23 0 8 9.0 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL240729 98361 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 763 23 0 8 9.0 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
11143090 58987 1 None -4 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 366 9 0 4 4.3 COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1 10.1021/jm020994z
CHEMBL158850 58987 1 None -4 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 366 9 0 4 4.3 COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1 10.1021/jm020994z
44437328 97757 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 678 17 0 8 6.7 COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239656 97757 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 678 17 0 8 6.7 COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
142601343 192382 0 None 30 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863868 192382 0 None 30 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
160510 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2003.09.027
CHEMBL1506260 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2003.09.027
CHEMBL295234 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2003.09.027
160510 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1021/acs.jmedchem.0c01887
CHEMBL1506260 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1021/acs.jmedchem.0c01887
CHEMBL295234 107904 40 None 3 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 184 0 1 1 2.5 CC1=NCCc2c1[nH]c1ccccc21 10.1021/acs.jmedchem.0c01887
155511929 183056 0 None -1 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4436319 183056 0 None -1 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595069 183056 0 None -1 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2019.06.028
13069603 127386 0 None -15 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 416 5 0 8 1.3 Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360993 127386 0 None -15 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 416 5 0 8 1.3 Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546107 127386 0 None -15 4 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 416 5 0 8 1.3 Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
168281754 197683 0 None -34 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 434 6 0 8 2.7 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5185101 197683 0 None -34 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 434 6 0 8 2.7 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
122483218 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764418 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765877 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
57390695 77242 0 None -21 8 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 427 7 0 5 5.5 O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL1946257 77242 0 None -21 8 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 427 7 0 5 5.5 O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
24768518 99614 0 None -46 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 461 11 1 3 5.9 CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243743 99614 0 None -46 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 461 11 1 3 5.9 CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
122483218 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764418 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765877 144890 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 425 7 0 4 5.4 O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
76328890 113195 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 278 4 0 2 4.0 Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121414 113195 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 278 4 0 2 4.0 Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139522 113195 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 278 4 0 2 4.0 Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21 10.1016/j.ejmech.2014.01.055
44347445 23064 0 None -1 4 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 277 0 0 3 3.0 CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL122485 23064 0 None -1 4 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 277 0 0 3 3.0 CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
145972025 171258 0 None 1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 409 4 1 3 4.1 O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4214208 171258 0 None 1 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 409 4 1 3 4.1 O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
127026142 144534 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 384 7 1 3 4.2 CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759273 144534 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 384 7 1 3 4.2 CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
155524957 183124 0 None -2 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4455845 183124 0 None -2 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595569 183124 0 None -2 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
127049061 147545 0 None -1 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 440 6 1 5 5.3 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3818398 147545 0 None -1 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 440 6 1 5 5.3 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
44582708 193617 0 None -2 5 Human 5.5 pKi = 5.5 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 415 10 0 5 4.2 COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1 10.1016/j.bmc.2009.03.021
CHEMBL489408 193617 0 None -2 5 Human 5.5 pKi = 5.5 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 415 10 0 5 4.2 COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1 10.1016/j.bmc.2009.03.021
155554462 181380 0 None -109 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 316 4 1 7 1.5 CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4557247 181380 0 None -109 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 316 4 1 7 1.5 CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
44460759 111003 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 275 3 0 3 2.4 CN1CCCN(CCn2ccc3ccc(F)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL309908 111003 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 275 3 0 3 2.4 CN1CCCN(CCn2ccc3ccc(F)cc32)CC1 10.1016/s0960-894x(02)00438-9
127049061 147545 0 None -1 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 440 6 1 5 5.3 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3818398 147545 0 None -1 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 440 6 1 5 5.3 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
162663279 190497 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 2 5 3.4 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4779939 190497 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 2 5 3.4 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803352 190497 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 2 5 3.4 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
156013588 183980 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 353 3 2 4 2.9 COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4635229 183980 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 353 3 2 4 2.9 COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
9817810 24144 1 None -12 8 Human 7.5 pKi = 7.5 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 300 4 1 4 2.4 NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL125745 24144 1 None -12 8 Human 7.5 pKi = 7.5 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 300 4 1 4 2.4 NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
137652310 164029 0 None 4 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4076525 164029 0 None 4 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 482 6 0 5 4.0 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
57399092 75209 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 468 9 0 6 3.5 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917355 75209 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 468 9 0 6 3.5 CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
145969402 171597 0 None 2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4218625 171597 0 None 2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
71451457 88202 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 394 8 1 5 3.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159470 88202 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 394 8 1 5 3.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1 10.1016/j.ejmech.2012.07.043
155543250 180078 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 275 1 1 2 3.3 Cn1cncc1-c1c[nH]c2ccc(Br)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4526012 180078 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 275 1 1 2 3.3 Cn1cncc1-c1c[nH]c2ccc(Br)cc12 10.1016/j.ejmech.2019.03.017
142601343 192382 0 None 30 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4863868 192382 0 None 30 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 256 2 2 3 2.2 Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
56944955 166470 0 None -7 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 465 6 2 3 5.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
CHEMBL4104216 166470 0 None -7 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 465 6 2 3 5.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 10.1021/acs.jmedchem.7b00839
118706284 127302 0 None -31 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 285 1 3 2 1.3 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310112 127302 0 None -31 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 285 1 3 2 1.3 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545440 127302 0 None -31 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 285 1 3 2 1.3 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2 10.1016/j.bmc.2014.05.027
118709753 120321 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 326 5 0 2 3.9 O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321795 120321 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 326 5 0 2 3.9 O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
66801335 118830 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 500 8 1 7 3.7 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289948 118830 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 500 8 1 7 3.7 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
109026956 180207 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 393 6 0 5 1.9 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4528701 180207 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 393 6 0 5 1.9 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2016.06.080
11102049 110149 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 429 6 2 3 4.9 COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3 10.1021/jm0104264
CHEMBL308461 110149 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 429 6 2 3 4.9 COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3 10.1021/jm0104264
162649235 186853 0 None -46 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 473 7 1 6 4.5 Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 10.1016/j.ejmech.2020.112149
CHEMBL4747978 186853 0 None -46 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 473 7 1 6 4.5 Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 10.1016/j.ejmech.2020.112149
9921064 133956 25 None -10 3 Human 6.5 pKi = 6.5 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 236 3 1 1 3.2 Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C 10.1021/acs.jmedchem.5b00179
CHEMBL365751 133956 25 None -10 3 Human 6.5 pKi = 6.5 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 236 3 1 1 3.2 Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C 10.1021/acs.jmedchem.5b00179
145964154 171099 0 None 7 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl 10.1021/acs.jmedchem.8b00828
CHEMBL4212339 171099 0 None 7 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 394 7 1 4 3.2 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl 10.1021/acs.jmedchem.8b00828
53317861 63794 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 318 4 1 3 3.9 COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644280 63794 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 318 4 1 3 3.9 COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
155549315 180608 0 None -144 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 448 9 0 6 4.1 COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4538667 180608 0 None -144 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 448 9 0 6 4.1 COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1 10.1016/j.bmcl.2019.06.029
155519599 183092 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4447594 183092 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595274 183092 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2019.06.028
10611439 103548 0 None -2 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 261 0 0 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O 10.1021/jm9911433
CHEMBL26471 103548 0 None -2 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 261 0 0 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O 10.1021/jm9911433
57401706 76946 0 None -50 11 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 331 6 0 4 3.5 Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
CHEMBL1940419 76946 0 None -50 11 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 331 6 0 4 3.5 Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
60165681 82131 0 None -102 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 413 7 0 5 5.1 O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037528 82131 0 None -102 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 413 7 0 5 5.1 O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
127027715 144457 0 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 452 7 0 4 4.0 O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1 10.1016/j.ejmech.2015.11.040
CHEMBL3758619 144457 0 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 452 7 0 4 4.0 O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1 10.1016/j.ejmech.2015.11.040
71455001 88214 0 None -1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 7 1 4 2.5 O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159482 88214 0 None -1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 7 1 4 2.5 O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
142601341 192151 0 None 3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4860503 192151 0 None 3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
9904281 54523 28 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 215 0 2 3 2.0 NC1=Nc2ccc(Cl)c(Cl)c2CN1 10.1016/j.bmcl.2007.10.080
CHEMBL1548 54523 28 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 215 0 2 3 2.0 NC1=Nc2ccc(Cl)c(Cl)c2CN1 10.1016/j.bmcl.2007.10.080
13069626 127383 0 None -295 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 440 8 0 9 1.4 COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3361000 127383 0 None -295 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 440 8 0 9 1.4 COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3546103 127383 0 None -295 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 440 8 0 9 1.4 COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
90654682 116880 0 None 6 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 438 7 1 4 2.6 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235754 116880 0 None 6 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 438 7 1 4 2.6 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.03.005
71602688 96460 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376457 96460 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2013.02.038
142601341 192151 0 None 3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4860503 192151 0 None 3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 272 3 2 4 1.9 COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
11560285 75190 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 394 7 1 3 4.0 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12 10.1016/j.bmc.2011.09.044
CHEMBL1917336 75190 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 394 7 1 3 4.0 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12 10.1016/j.bmc.2011.09.044
53377241 73420 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 427 6 0 6 3.9 Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1852852 73420 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 427 6 0 6 3.9 Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216488 73420 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 427 6 0 6 3.9 Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.04.060
25107717 194329 1 None -6 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 420 10 1 5 3.6 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
CHEMBL494512 194329 1 None -6 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 420 10 1 5 3.6 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
42618260 188329 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 458 7 0 7 3.6 COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
CHEMBL476615 188329 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 458 7 0 7 3.6 COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
417052 123633 43 None -3 4 Human 5.5 pKi = 5.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 214 1 1 2 2.5 COc1ccc2[nH]c3c(c2c1)CCN=C3C 10.1016/j.bmcl.2003.09.027
CHEMBL338115 123633 43 None -3 4 Human 5.5 pKi = 5.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 214 1 1 2 2.5 COc1ccc2[nH]c3c(c2c1)CCN=C3C 10.1016/j.bmcl.2003.09.027
71602688 96460 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376457 96460 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 392 5 0 3 5.3 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2013.02.038
155514889 176691 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 520 10 1 8 3.3 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4440973 176691 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 520 10 1 8 3.3 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
11283795 148818 0 None 3 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 483 9 1 5 4.0 CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL387738 148818 0 None 3 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 483 9 1 5 4.0 CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
56850390 78259 0 None -245 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926733 78259 0 None -245 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962486 78259 0 None -245 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
46204421 131339 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 343 5 0 3 4.6 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1 nan
CHEMBL3640568 131339 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 343 5 0 3 4.6 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1 nan
46206021 131379 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 253 3 1 2 3.4 COc1ccccc1-c1ccccc1C1CCNC1 nan
CHEMBL3640607 131379 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 253 3 1 2 3.4 COc1ccccc1-c1ccccc1C1CCNC1 nan
46204421 131339 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 343 5 0 3 4.6 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1 nan
CHEMBL3640568 131339 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 343 5 0 3 4.6 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1 nan
46206021 131379 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 253 3 1 2 3.4 COc1ccccc1-c1ccccc1C1CCNC1 nan
CHEMBL3640607 131379 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 253 3 1 2 3.4 COc1ccccc1-c1ccccc1C1CCNC1 nan
90469115 192621 4 None -1000 17 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 410 3 1 6 3.0 O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
CHEMBL4867565 192621 4 None -1000 17 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 410 3 1 6 3.0 O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
10154897 72037 0 None - 1 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 350 8 3 7 3.1 CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.ejmech.2019.111705
CHEMBL182797 72037 0 None - 1 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 350 8 3 7 3.1 CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.ejmech.2019.111705
86288948 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2019.111705
CHEMBL3233679 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2019.111705
CHEMBL3302600 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2019.111705
44393228 71572 1 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL181950 71572 1 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 317 7 2 3 4.9 C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
12088080 71654 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 350 8 3 7 3.1 C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL182174 71654 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 350 8 3 7 3.1 C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
44393069 72865 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 8 2 6 3.5 C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL183862 72865 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 8 2 6 3.5 C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
11151899 8918 13 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2021.128275
8432 8918 13 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2021.128275
CHEMBL4205783 8918 13 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2021.128275
9863250 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm030030n
CHEMBL12624 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm030030n
9885982 110961 0 None 1348 2 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 3 0 3 4.0 Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
CHEMBL309750 110961 0 None 1348 2 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 3 0 3 4.0 Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
9885982 110961 0 None 1348 2 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 375 3 0 3 4.0 Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL309750 110961 0 None 1348 2 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 375 3 0 3 4.0 Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
9863250 24767 6 None 1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm049743b
CHEMBL12624 24767 6 None 1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm049743b
118626121 172199 0 None 1 5 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4238479 172199 0 None 1 5 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
145983961 172204 0 None -3 5 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4238679 172204 0 None -3 5 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
86288948 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233679 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3302600 119403 0 None 39 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 10.1016/j.ejmech.2014.01.065
145990353 173577 0 None 42 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 488 7 2 6 2.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1 10.1039/C8MD00168E
CHEMBL4284331 173577 0 None 42 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 488 7 2 6 2.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1 10.1039/C8MD00168E
145988738 174004 0 None 42 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 483 6 2 6 2.7 CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4292237 174004 0 None 42 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 483 6 2 6 2.7 CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1039/C8MD00168E
276 10286 50 None -100 13 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.ejmech.2020.113059
5312149 10286 50 None -100 13 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.ejmech.2020.113059
CHEMBL431298 10286 50 None -100 13 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/j.ejmech.2020.113059
10495891 105880 0 None 6 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 319 3 0 2 4.4 CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL280804 105880 0 None 6 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 319 3 0 2 4.4 CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
90656710 117754 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 310 6 1 3 3.5 Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262410 117754 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 310 6 1 3 3.5 Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
9863250 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/acs.jmedchem.7b01898
CHEMBL12624 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/acs.jmedchem.7b01898
5 6927 72 None -3 53 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0341204
5202 6927 72 None -3 53 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0341204
CHEMBL39 6927 72 None -3 53 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0341204
DB08839 6927 72 None -3 53 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0341204
44364048 45913 0 None -1 6 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 262 6 3 3 2.3 NCCCC1(CCCN)CCc2cccc(O)c2C1 10.1021/jm0341204
CHEMBL146942 45913 0 None -1 6 Human 8.5 pKi = 8.5 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 262 6 3 3 2.3 NCCCC1(CCCN)CCc2cccc(O)c2C1 10.1021/jm0341204
9863250 24767 6 None 1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1016/s0960-894x(00)00166-9
CHEMBL12624 24767 6 None 1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1016/s0960-894x(00)00166-9
9863250 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm991151j
CHEMBL12624 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm991151j
9863250 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm030841r
CHEMBL12624 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1021/jm030841r
10500557 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL12427 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
10500557 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
CHEMBL12427 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
9863250 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1016/j.ejmech.2019.111705
CHEMBL12624 24767 6 None -1 7 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 350 5 0 3 3.3 Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 10.1016/j.ejmech.2019.111705
2389 10104 118 None -7 66 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.bmcl.2015.09.045
5073 10104 118 None -7 66 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.bmcl.2015.09.045
96 10104 118 None -7 66 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.bmcl.2015.09.045
CHEMBL85 10104 118 None -7 66 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.bmcl.2015.09.045
DB00734 10104 118 None -7 66 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.bmcl.2015.09.045
10028436 10305 5 None -1 12 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.ejmech.2012.07.043
3237 10305 5 None -1 12 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.ejmech.2012.07.043
CHEMBL95104 10305 5 None -1 12 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 10.1016/j.ejmech.2012.07.043
145977297 170413 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 350 4 1 3 3.8 OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2017.11.007
CHEMBL4203932 170413 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
ChEMBL 350 4 1 3 3.8 OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2017.11.007
66801230 118833 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 436 8 1 7 3.2 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3289951 118833 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 436 8 1 7 3.2 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
56943600 118892 0 None -5 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 515 8 1 5 5.7 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3290008 118892 0 None -5 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 515 8 1 5 5.7 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
66801186 118902 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 457 7 1 7 3.2 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
CHEMBL3290018 118902 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 457 7 1 7 3.2 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
155545402 180168 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells
ChEMBL 391 6 1 3 3.8 O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32 10.1016/j.ejmech.2019.111690
CHEMBL4527987 180168 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells
ChEMBL 391 6 1 3 3.8 O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32 10.1016/j.ejmech.2019.111690
11536844 121900 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343672 121900 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
145987771 173868 0 None 5 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 431 6 1 2 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.ejmech.2017.12.063
CHEMBL4289783 173868 0 None 5 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
ChEMBL 431 6 1 2 5.9 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 10.1016/j.ejmech.2017.12.063
44276598 102458 0 None -1 4 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 386 6 1 2 5.2 O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0108505
CHEMBL25815 102458 0 None -1 4 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 386 6 1 2 5.2 O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0108505
8431 8266 9 None 22 5 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2009.12.027
9843179 8266 9 None 22 5 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2009.12.027
CHEMBL69257 8266 9 None 22 5 Human 8.5 pKi = 8.5 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1016/j.bmcl.2009.12.027
10500557 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm0104264
CHEMBL12427 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm0104264
10500557 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
CHEMBL12427 23452 0 None - 1 Human 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 389 6 1 3 4.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
10825325 106200 0 None 1 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 261 0 0 1 3.9 C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL282863 106200 0 None 1 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 261 0 0 1 3.9 C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
11267988 73603 0 None -2 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 309 6 0 2 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2010.01.035
CHEMBL186112 73603 0 None -2 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 309 6 0 2 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2010.01.035
11186985 130624 0 None -3 4 Rat 8.5 pKi = 8.5 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1021/jm0498102
CHEMBL362540 130624 0 None -3 4 Rat 8.5 pKi = 8.5 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1021/jm0498102
23369416 189266 2 None -3 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 366 6 1 5 2.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL478680 189266 2 None -3 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 366 6 1 5 2.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
66801379 118848 0 None 2 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 8 3.8 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3289966 118848 0 None 2 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 8 3.8 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
24854267 164680 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 385 6 1 3 4.0 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm070279v
CHEMBL408426 164680 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 385 6 1 3 4.0 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm070279v
155512409 176423 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 6 0 6 4.3 Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O 10.1016/j.ejmech.2019.111690
CHEMBL4437217 176423 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 6 0 6 4.3 Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O 10.1016/j.ejmech.2019.111690
155546781 180407 0 None 36 2 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2 10.1016/j.ejmech.2019.111705
CHEMBL4533865 180407 0 None 36 2 Human 8.5 pKi = 8.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2 10.1016/j.ejmech.2019.111705
11025847 170087 0 None - 1 Human 8.5 pKi = 8.5 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 404 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
CHEMBL418888 170087 0 None - 1 Human 8.5 pKi = 8.5 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 404 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
11025847 170087 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 404 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1021/jm0104264
CHEMBL418888 170087 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 404 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3 10.1021/jm0104264
9956365 202297 0 None 34 3 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL553794 202297 0 None 34 3 Human 8.5 pKi = 8.5 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
91864602 147516 0 None 2 8 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 313 5 0 2 4.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818047 147516 0 None 2 8 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 313 5 0 2 4.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.05.053
9956365 202297 0 None 34 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm070279v
CHEMBL553794 202297 0 None 34 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm070279v
91864602 147516 0 None 2 8 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 313 5 0 2 4.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818047 147516 0 None 2 8 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 313 5 0 2 4.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 10.1016/j.bmc.2016.05.053
11016205 211547 1 None -2 5 Human 8.4 pKi = 8.4 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 10.1021/jm0200411
CHEMBL74756 211547 1 None -2 5 Human 8.4 pKi = 8.4 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 10.1021/jm0200411
11978813 7508 79 None -6 24 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.1016/j.ejmech.2019.111736
5014 7508 79 None -6 24 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.1016/j.ejmech.2019.111736
7672 7508 79 None -6 24 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.1016/j.ejmech.2019.111736
CHEMBL2105760 7508 79 None -6 24 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.1016/j.ejmech.2019.111736
DB09128 7508 79 None -6 24 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.1016/j.ejmech.2019.111736
4106 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
5358812 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
89 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
CHEMBL93240 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
24854044 104074 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm070279v
CHEMBL269083 104074 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm070279v
46196448 131320 1 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 323 4 1 3 3.7 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640550 131320 1 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 323 4 1 3 3.7 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
11725453 105856 0 None 1 6 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030030n
CHEMBL28056 105856 0 None 1 6 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030030n
46196448 131320 1 None - 1 Rat 8.4 pKi = 8.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 323 4 1 3 3.7 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
CHEMBL3640550 131320 1 None - 1 Rat 8.4 pKi = 8.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 323 4 1 3 3.7 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1 nan
11725453 105856 0 None 1 6 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1016/j.bmc.2020.115578
CHEMBL28056 105856 0 None 1 6 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1016/j.bmc.2020.115578
11725453 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
CHEMBL28056 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
11725453 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0498102
CHEMBL28056 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0498102
66800942 118822 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 416 6 1 6 2.7 Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
CHEMBL3289708 118822 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 416 6 1 6 2.7 Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1 10.1021/jm401895u
11465618 109175 23 None -14 19 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL3039528 109175 23 None -14 19 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL5191141 109175 23 None -14 19 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
10811746 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL273246 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
10811746 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm980519u
CHEMBL273246 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm980519u
25107648 194002 0 None 25 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 10.1021/jm800615e
CHEMBL492480 194002 0 None 25 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 10.1021/jm800615e
76284724 111781 0 None 39 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 490 11 1 5 4.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113593 111781 0 None 39 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 490 11 1 5 4.9 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1 10.1016/j.bmc.2014.01.016
11047374 25681 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 388 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 10.1021/jm0104264
CHEMBL12846 25681 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 388 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 10.1021/jm0104264
10835110 121366 0 None 79 8 Human 8.4 pKi = 8.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 404 5 0 3 4.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm991151j
CHEMBL333784 121366 0 None 79 8 Human 8.4 pKi = 8.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 404 5 0 3 4.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm991151j
44368732 52922 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 404 5 0 3 4.3 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030841r
CHEMBL153398 52922 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 404 5 0 3 4.3 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030841r
11725453 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
CHEMBL28056 105856 0 None -1 6 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
ChEMBL 350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm030841r
10811746 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL273246 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/s0960-894x(00)00166-9
10811746 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm030841r
CHEMBL273246 104846 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 414 6 1 4 4.1 N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm030841r
162656718 187737 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 403 7 1 5 3.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1 10.1016/j.ejmech.2020.112149
CHEMBL4758402 187737 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 403 7 1 5 3.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1 10.1016/j.ejmech.2020.112149
4106 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2019.111705
5358812 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2019.111705
89 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2019.111705
CHEMBL93240 9280 22 None -4 33 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.ejmech.2019.111705
145 6928 49 None -2 30 Human 7.5 pKi = 7.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030030n
1832 6928 49 None -2 30 Human 7.5 pKi = 7.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030030n
CHEMBL7257 6928 49 None -2 30 Human 7.5 pKi = 7.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030030n
DB14010 6928 49 None -2 30 Human 7.5 pKi = 7.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030030n
398712 84644 5 None -30 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 417 9 1 5 2.9 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm0508641
CHEMBL209324 84644 5 None -30 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 417 9 1 5 2.9 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm0508641
122483281 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3763779 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765873 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL5083607 221652 0 None -2 9 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
71574212 93059 0 None -3 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312935 93059 0 None -3 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 10.1016/j.ejmech.2012.11.042
118731349 124964 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 3.5 CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409033 124964 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 3.5 CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
118731359 124973 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 532 10 0 5 4.3 O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409042 124973 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 532 10 0 5 4.3 O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
156014079 184035 0 None 1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 508 10 1 6 5.1 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12 10.1016/j.bmc.2020.115459
CHEMBL4636031 184035 0 None 1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 508 10 1 6 5.1 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12 10.1016/j.bmc.2020.115459
138691338 170446 0 None 21 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 241 3 1 3 3.1 CCn1cncc1-c1c[nH]c2ccc(OC)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4204595 170446 0 None 21 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 241 3 1 3 3.1 CCn1cncc1-c1c[nH]c2ccc(OC)cc12 10.1016/j.ejmech.2019.03.017
11425677 189114 0 None -1 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 269 1 1 3 3.0 CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4784424 189114 0 None -1 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 269 1 1 3 3.0 CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2 10.1016/j.bmcl.2020.127669
138691338 170446 0 None 21 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis
ChEMBL 241 3 1 3 3.1 CCn1cncc1-c1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.7b01898
CHEMBL4204595 170446 0 None 21 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis
ChEMBL 241 3 1 3 3.1 CCn1cncc1-c1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.7b01898
90656694 117772 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 339 7 1 4 3.4 CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262428 117772 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 339 7 1 4 3.4 CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
10171 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030030n
272 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030030n
CHEMBL274384 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1021/jm030030n
122483281 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3763779 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765873 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
67268994 170747 2 None 3 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None 3 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
118736368 125718 0 None -7 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 527 7 1 10 2.7 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423332 125718 0 None -7 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 527 7 1 10 2.7 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
11786227 179384 0 None 1 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
CHEMBL449089 179384 0 None 1 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
118728510 124483 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 5 4.1 Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401473 124483 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 1 5 4.1 Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL5083607 221652 0 None -2 9 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl 10.1021/acs.jmedchem.1c00110
122483281 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3763779 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765873 144886 0 None -6 8 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 0 5 5.4 COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
12 8335 17 None -13 7 Human 6.5 pKi = 6.5 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1021/jm990550b
6918513 8335 17 None -13 7 Human 6.5 pKi = 6.5 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1021/jm990550b
CHEMBL267615 8335 17 None -13 7 Human 6.5 pKi = 6.5 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10.1021/jm990550b
162671716 190541 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 3.3 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4792591 190541 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 3.3 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803839 190541 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 3.3 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
44439405 98587 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 440 4 0 5 5.3 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL241282 98587 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 440 4 0 5 5.3 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2 10.1016/j.bmcl.2007.01.093
417052 123633 43 None -3 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 214 1 1 2 2.5 COc1ccc2[nH]c3c(c2c1)CCN=C3C 10.1021/acs.jmedchem.0c01887
CHEMBL338115 123633 43 None -3 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 214 1 1 2 2.5 COc1ccc2[nH]c3c(c2c1)CCN=C3C 10.1021/acs.jmedchem.0c01887
72711487 109371 0 None -11 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 411 10 1 5 3.0 COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12 10.1021/jm400766k
CHEMBL2431040 109371 0 None -11 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 411 10 1 5 3.0 COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12 10.1021/jm400766k
CHEMBL3040890 109371 0 None -11 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 411 10 1 5 3.0 COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12 10.1021/jm400766k
57399088 75191 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 373 8 1 4 2.1 NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917337 75191 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 373 8 1 4 2.1 NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
90654676 116874 0 None -25 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 464 9 1 5 2.8 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235748 116874 0 None -25 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 464 9 1 5 2.8 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
138691366 181737 0 None 7 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 229 2 1 2 3.2 CCn1cncc1-c1c[nH]c2ccc(F)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4565881 181737 0 None 7 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 229 2 1 2 3.2 CCn1cncc1-c1c[nH]c2ccc(F)cc12 10.1016/j.ejmech.2019.03.017
145946733 174359 0 None -20 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 368 7 0 4 4.2 COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1 10.1016/j.bmcl.2018.04.059
CHEMBL4205526 174359 0 None -20 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 368 7 0 4 4.2 COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1 10.1016/j.bmcl.2018.04.059
CHEMBL4300710 174359 0 None -20 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 368 7 0 4 4.2 COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1 10.1016/j.bmcl.2018.04.059
173 10036 95 None -34 23 Human 5.5 pKi = 5.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 10.1021/jm030030n
5011 10036 95 None -34 23 Human 5.5 pKi = 5.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 10.1021/jm030030n
CHEMBL18772 10036 95 None -34 23 Human 5.5 pKi = 5.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 10.1021/jm030030n
1355 8792 88 None -14 16 Human 6.5 pKi = 6.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm030030n
142 8792 88 None -14 16 Human 6.5 pKi = 6.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm030030n
CHEMBL478 8792 88 None -14 16 Human 6.5 pKi = 6.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm030030n
DB12110 8792 88 None -14 16 Human 6.5 pKi = 6.5 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm030030n
134144798 157026 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 325 5 0 3 4.6 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
CHEMBL3952371 157026 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 325 5 0 3 4.6 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
118728521 124494 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 376 7 0 5 3.4 O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401484 124494 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 376 7 0 5 3.4 O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2015.02.042
156019563 184766 0 None -3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 364 5 0 4 4.1 C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4646172 184766 0 None -3 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 364 5 0 4 4.1 C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
71602691 96463 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 372 5 0 3 5.0 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376460 96463 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 372 5 0 3 5.0 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2013.02.038
122483260 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763275 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765848 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
11121216 36912 0 None -15 14 Human 7.5 pKi = 7.5 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL138989 36912 0 None -15 14 Human 7.5 pKi = 7.5 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 335 1 1 2 3.0 C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
88912137 117475 0 None 19 4 Rat 7.5 pKi = 7.5 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 405 5 1 3 5.2 C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1 10.1021/ml500082j
CHEMBL3260337 117475 0 None 19 4 Rat 7.5 pKi = 7.5 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 405 5 1 3 5.2 C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1 10.1021/ml500082j
44460471 212364 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 335 3 0 3 3.0 CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL81424 212364 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 335 3 0 3 3.0 CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
145986138 172248 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 492 6 0 6 4.4 O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4239705 172248 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 492 6 0 6 4.4 O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
71574302 93039 0 None -2 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312637 93039 0 None -2 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 10.1016/j.ejmech.2012.11.042
71574208 93044 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312642 93044 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1 10.1016/j.ejmech.2012.11.042
156019543 184715 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 508 10 1 6 5.1 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2020.115459
CHEMBL4645525 184715 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 508 10 1 6 5.1 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2020.115459
90654854 119460 0 None 2 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233676 119460 0 None 2 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304183 119460 0 None 2 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.01.065
156009483 183845 0 None 7 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 412 5 1 5 2.8 C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4632872 183845 0 None 7 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 412 5 1 5 2.8 C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
42618272 97974 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 435 6 0 4 3.6 O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
CHEMBL239898 97974 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 435 6 0 4 3.6 O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.07.029
25107517 194035 0 None -1 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 0 4 4.0 COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL492690 194035 0 None -1 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 0 4 4.0 COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
72551082 120858 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326985 120858 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2014.07.026
11168662 91407 0 None -1 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
CHEMBL222262 91407 0 None -1 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.ejmech.2019.111705
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.ejmech.2019.111705
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.ejmech.2019.111705
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/acs.jmedchem.7b01898
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/acs.jmedchem.7b01898
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/acs.jmedchem.7b01898
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.bmc.2013.02.038
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.bmc.2013.02.038
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/j.bmc.2013.02.038
281 10283 28 None -1 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm0108505
5312148 10283 28 None -1 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm0108505
CHEMBL12264 10283 28 None -1 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm0108505
3233 10285 44 None -2 12 Rat 7.5 pKi = 7.5 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
3247 10285 44 None -2 12 Rat 7.5 pKi = 7.5 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
6604889 10285 44 None -2 12 Rat 7.5 pKi = 7.5 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
CHEMBL282199 10285 44 None -2 12 Rat 7.5 pKi = 7.5 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
DB13988 10285 44 None -2 12 Rat 7.5 pKi = 7.5 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10.1021/jm030841r
9820952 25510 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm970519e
CHEMBL12777 25510 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm970519e
10715573 105267 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 392 6 0 3 4.1 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm970519e
CHEMBL275996 105267 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 392 6 0 3 4.1 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm970519e
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(00)00166-9
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(00)00166-9
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(00)00166-9
9820952 25510 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12777 25510 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1016/s0960-894x(00)00166-9
10715573 105267 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 392 6 0 3 4.1 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL275996 105267 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 392 6 0 3 4.1 CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00166-9
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
44368358 126450 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
CHEMBL347115 126450 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030841r
44368306 171668 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 391 6 0 3 4.9 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030841r
CHEMBL422146 171668 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 391 6 0 3 4.9 CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030841r
142601337 192749 0 None 53 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4869695 192749 0 None 53 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
162674561 190050 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 403 7 1 5 3.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1 10.1016/j.ejmech.2020.112149
CHEMBL4796647 190050 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 403 7 1 5 3.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1 10.1016/j.ejmech.2020.112149
10171 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/j.ejmech.2019.111705
272 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/j.ejmech.2019.111705
CHEMBL274384 6845 18 None -11 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 10.1016/j.ejmech.2019.111705
67268994 170747 2 None 3 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4207884 170747 2 None 3 7 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
2726 7706 68 None -13 72 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm070516u
621 7706 68 None -13 72 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm070516u
83 7706 68 None -13 72 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm070516u
CHEMBL71 7706 68 None -13 72 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm070516u
DB00477 7706 68 None -13 72 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1021/jm070516u
44324627 213544 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 257 2 2 4 3.1 Cc1c(NC2=NCCN2)cccc1-c1ccsc1 10.1016/s0960-894x(02)00925-3
CHEMBL90118 213544 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 257 2 2 4 3.1 Cc1c(NC2=NCCN2)cccc1-c1ccsc1 10.1016/s0960-894x(02)00925-3
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm970519e
57403839 78321 0 None -1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949967 78321 0 None -1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963008 78321 0 None -1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
90656708 117771 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 415 8 1 4 5.5 CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262427 117771 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 415 8 1 4 5.5 CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
46205699 131372 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1cccc(-c2ccccc2C2CCN(C)C2)c1 nan
CHEMBL3640600 131372 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1cccc(-c2ccccc2C2CCN(C)C2)c1 nan
46205699 131372 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1cccc(-c2ccccc2C2CCN(C)C2)c1 nan
CHEMBL3640600 131372 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1cccc(-c2ccccc2C2CCN(C)C2)c1 nan
71449550 87943 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 9 1 4 4.5 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158034 87943 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 410 9 1 4 4.5 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1 10.1016/j.ejmech.2012.07.043
71602691 96463 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 372 5 0 3 5.0 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376460 96463 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 372 5 0 3 5.0 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1 10.1016/j.bmc.2013.02.038
156014279 184009 0 None -20 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 348 5 1 2 5.0 CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3 10.1016/j.bmc.2020.115578
CHEMBL4635676 184009 0 None -20 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 348 5 1 2 5.0 CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3 10.1016/j.bmc.2020.115578
122483260 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3763275 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765848 144878 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 424 7 0 3 6.6 O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
145973487 171399 0 None 8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1 10.1021/acs.jmedchem.8b00828
CHEMBL4216022 171399 0 None 8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1 10.1021/acs.jmedchem.8b00828
127052486 147601 0 None -3 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 424 6 1 5 4.8 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819153 147601 0 None -3 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 424 6 1 5 4.8 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 10.1016/j.bmc.2016.06.011
90654698 116861 0 None -22 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 390 8 1 4 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235735 116861 0 None -22 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 390 8 1 4 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2014.03.005
145947944 174510 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 336 9 1 5 1.6 Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4208428 174510 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 336 9 1 5 1.6 Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4302764 174510 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 336 9 1 5 1.6 Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1 10.1016/j.bmcl.2018.04.059
155511262 176323 0 None -109 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4435528 176323 0 None -109 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 362 7 3 4 4.5 COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1 10.1016/j.ejmech.2019.111857
11151899 8918 13 None -5 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.ejmech.2019.111705
8432 8918 13 None -5 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.ejmech.2019.111705
CHEMBL4205783 8918 13 None -5 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.ejmech.2019.111705
135367959 171389 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 214 1 1 3 2.0 c1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215925 171389 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 214 1 1 3 2.0 c1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
1353 8692 93 None -263 85 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm070516u
3559 8692 93 None -263 85 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm070516u
86 8692 93 None -263 85 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm070516u
CHEMBL54 8692 93 None -263 85 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm070516u
DB00502 8692 93 None -263 85 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm070516u
127052486 147601 0 None -3 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 424 6 1 5 4.8 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL3819153 147601 0 None -3 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 424 6 1 5 4.8 O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 10.1016/j.bmc.2016.06.011
145947088 174403 0 None -6 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 9 0 4 3.8 Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4208181 174403 0 None -6 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 9 0 4 3.8 Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
CHEMBL4301443 174403 0 None -6 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 9 0 4 3.8 Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1 10.1016/j.bmcl.2018.04.059
6918648 108336 1 None -5128 14 Human 5.5 pKi = 5.5 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1021/jm980532e
CHEMBL29846 108336 1 None -5128 14 Human 5.5 pKi = 5.5 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1021/jm980532e
6918648 108336 1 None -5128 14 Human 5.5 pKi = 5.5 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1016/s0960-894x(02)00172-5
CHEMBL29846 108336 1 None -5128 14 Human 5.5 pKi = 5.5 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1016/s0960-894x(02)00172-5
76314436 113044 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 292 4 0 2 4.4 Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
CHEMBL3121415 113044 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 292 4 0 2 4.4 Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
CHEMBL3139010 113044 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 292 4 0 2 4.4 Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C 10.1016/j.ejmech.2014.01.055
19958494 106229 1 None -9 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 360 3 1 3 3.9 FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
CHEMBL283036 106229 1 None -9 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 360 3 1 3 3.9 FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
122187 10474 17 None -104 5 Rat 5.5 pKi = 5.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 265 5 1 2 3.5 CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC 10.1021/jm9911433
61 10474 17 None -104 5 Rat 5.5 pKi = 5.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 265 5 1 2 3.5 CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC 10.1021/jm9911433
CHEMBL22778 10474 17 None -104 5 Rat 5.5 pKi = 5.5 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 265 5 1 2 3.5 CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC 10.1021/jm9911433
18133517 171201 0 None 16 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4213576 171201 0 None 16 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
127027391 144610 0 None 8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 468 7 0 4 4.5 O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1 10.1016/j.ejmech.2015.11.040
CHEMBL3759885 144610 0 None 8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 468 7 0 4 4.5 O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1 10.1016/j.ejmech.2015.11.040
162672202 190543 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 2.6 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4790910 190543 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 2.6 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803865 190543 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 383 8 2 5 2.6 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
135367959 171389 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 214 1 1 3 2.0 c1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4215925 171389 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 214 1 1 3 2.0 c1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030030n
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030030n
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030030n
44268087 26966 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
CHEMBL13049 26966 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(02)00438-9
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(02)00438-9
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1016/s0960-894x(02)00438-9
145983794 172433 0 None -2 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 0 6 5.2 O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4244280 172433 0 None -2 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 0 6 5.2 O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
134137332 149786 0 None 12 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 530 10 1 5 4.8 O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3894679 149786 0 None 12 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 530 10 1 5 4.8 O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
145976890 170596 0 None 21 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 8 1 4 5.2 CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4206203 170596 0 None 21 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 8 1 4 5.2 CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2017.03.057
145974189 171405 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 9 1 4 4.2 CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4216126 171405 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 9 1 4 4.2 CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
142601337 192749 0 None 53 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4869695 192749 0 None 53 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 260 2 2 3 2.0 Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
137654666 165395 0 None -44 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4092243 165395 0 None -44 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
10667433 155577 0 None 6 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 379 7 0 4 3.2 COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 10.1021/jm8014553
CHEMBL394080 155577 0 None 6 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 379 7 0 4 3.2 COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 10.1021/jm8014553
72547878 120861 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 517 12 1 6 5.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326988 120861 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 517 12 1 6 5.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1 10.1016/j.bmc.2014.07.026
155568373 182873 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 412 5 0 4 3.2 O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4591320 182873 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 412 5 0 4 3.2 O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
25107515 194139 0 None -16 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 0 4 4.7 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL493305 194139 0 None -16 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 0 4 4.7 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
155568246 182879 0 None -138 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 528 9 2 5 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
CHEMBL4591440 182879 0 None -138 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 528 9 2 5 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
44374227 175143 2 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1ncc(-c2ccccc2)s1 10.1016/j.bmcl.2003.11.050
CHEMBL434477 175143 2 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 264 5 0 4 3.5 CN(C)CCSc1ncc(-c2ccccc2)s1 10.1016/j.bmcl.2003.11.050
16117279 66910 0 None -3235 7 Human 5.5 pKi = 5.5 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 398 5 3 5 3.7 CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 10.1016/j.bmc.2010.10.033
CHEMBL1642886 66910 0 None -3235 7 Human 5.5 pKi = 5.5 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 398 5 3 5 3.7 CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 10.1016/j.bmc.2010.10.033
CHEMBL1739606 66910 0 None -3235 7 Human 5.5 pKi = 5.5 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 398 5 3 5 3.7 CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 10.1016/j.bmc.2010.10.033
121209051 171167 5 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 213 1 2 2 1.8 c1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4213135 171167 5 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 213 1 2 2 1.8 c1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
162643049 190392 0 None -22 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4776078 190392 0 None -22 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4802282 190392 0 None -22 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
121209051 171167 5 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 213 1 2 2 1.8 c1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4213135 171167 5 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 213 1 2 2 1.8 c1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
134130846 149068 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 7 0 5 4.4 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3885178 149068 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 7 0 5 4.4 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2016.12.039
11948707 172946 0 None -158 13 Human 6.5 pKi = 6.5 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 373 7 0 8 0.6 COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 10.1016/j.bmcl.2006.01.052
CHEMBL426317 172946 0 None -158 13 Human 6.5 pKi = 6.5 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 373 7 0 8 0.6 COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 10.1016/j.bmcl.2006.01.052
53377237 73163 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851771 73163 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3215834 73163 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 447 6 0 6 4.2 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2011.04.060
162661942 190490 3 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 7 2 5 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4778949 190490 3 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 7 2 5 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803285 190490 3 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 7 2 5 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1 10.1016/j.ejmech.2020.112437
44424656 92530 0 None -1 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 470 9 0 10 1.4 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229124 92530 0 None -1 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 470 9 0 10 1.4 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
162668661 190520 0 None -11 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 8 1 6 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4789408 190520 0 None -11 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 8 1 6 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803658 190520 0 None -11 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 453 8 1 6 4.2 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
71462067 87944 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 460 9 1 4 5.7 CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158035 87944 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 460 9 1 4 5.7 CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1 10.1016/j.ejmech.2012.07.043
60165416 82071 0 None -83 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 385 6 0 4 5.1 Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
CHEMBL2037431 82071 0 None -83 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 385 6 0 4 5.1 Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
71459954 85957 0 None -331 7 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 495 6 3 3 4.0 O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 10.1021/jm049243i
CHEMBL2113386 85957 0 None -331 7 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 495 6 3 3 4.0 O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 10.1021/jm049243i
46206020 131378 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1ccccc1-c1ccccc1C1CCN(C)C1 nan
CHEMBL3640606 131378 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1ccccc1-c1ccccc1C1CCN(C)C1 nan
46206020 131378 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1ccccc1-c1ccccc1C1CCN(C)C1 nan
CHEMBL3640606 131378 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1ccccc1-c1ccccc1C1CCN(C)C1 nan
155541866 179828 0 None -95 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 8 2 4 4.8 COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4519266 179828 0 None -95 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 8 2 4 4.8 COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
44393114 70410 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL180087 70410 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
76336177 113048 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 378 4 0 2 6.2 Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121412 113048 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 378 4 0 2 6.2 Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139015 113048 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 378 4 0 2 6.2 Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
57399093 75214 0 None 9 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 443 9 0 4 4.9 CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
CHEMBL1917360 75214 0 None 9 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 443 9 0 4 4.9 CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
132938109 171082 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 500 9 2 5 4.2 O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.bmc.2017.03.057
CHEMBL4212199 171082 0 None 8 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 500 9 2 5 4.2 O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.bmc.2017.03.057
156019750 184794 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 254 2 0 2 3.1 CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1 10.1016/j.bmc.2019.115262
CHEMBL4646587 184794 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 254 2 0 2 3.1 CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1 10.1016/j.bmc.2019.115262
11666595 127310 0 None -301 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310115 127310 0 None -301 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545467 127310 0 None -301 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2 10.1016/j.bmc.2014.05.027
56945045 118838 0 None -4 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 514 8 1 6 5.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3289956 118838 0 None -4 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 514 8 1 6 5.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
135458393 162375 4 None -2 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 259 2 2 3 2.8 CC1NC(NCC(F)F)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL404511 162375 4 None -2 5 Human 7.5 pKi = 7.5 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 259 2 2 3 2.8 CC1NC(NCC(F)F)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
24854108 164687 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 391 7 0 3 4.3 CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21 10.1021/jm070279v
CHEMBL408429 164687 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 391 7 0 3 4.3 CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21 10.1021/jm070279v
76335863 111786 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 487 11 1 5 4.5 COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113598 111786 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 487 11 1 5 4.5 COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1 10.1016/j.bmc.2014.01.016
46203753 131322 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 280 4 1 4 2.6 COc1ccc(-c2ccccc2C#N)cc1OC1CNC1 nan
CHEMBL3640552 131322 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 280 4 1 4 2.6 COc1ccc(-c2ccccc2C#N)cc1OC1CNC1 nan
12741421 213538 8 None -22 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 261 6 0 2 3.7 CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
CHEMBL90053 213538 8 None -22 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 261 6 0 2 3.7 CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
46203753 131322 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 280 4 1 4 2.6 COc1ccc(-c2ccccc2C#N)cc1OC1CNC1 nan
CHEMBL3640552 131322 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 280 4 1 4 2.6 COc1ccc(-c2ccccc2C#N)cc1OC1CNC1 nan
24841480 190678 0 None -165 20 Human 6.5 pKi = 6.5 Binding
Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay
ChEMBL 340 3 0 4 4.5 O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
CHEMBL481153 190678 0 None -165 20 Human 6.5 pKi = 6.5 Binding
Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay
ChEMBL 340 3 0 4 4.5 O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
127052465 147509 0 None -8 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 340 5 0 3 3.6 O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 10.1016/j.bmc.2016.05.053
CHEMBL3817911 147509 0 None -8 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 340 5 0 3 3.6 O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 10.1016/j.bmc.2016.05.053
145977799 170422 0 None -4 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 257 3 1 3 2.9 C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1 10.1021/acs.jnatprod.7b00317
CHEMBL4204036 170422 0 None -4 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 257 3 1 3 2.9 C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1 10.1021/acs.jnatprod.7b00317
162669562 189481 0 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 6 0 4 4.2 O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4789472 189481 0 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 6 0 4 4.2 O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
127052465 147509 0 None -8 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 340 5 0 3 3.6 O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 10.1016/j.bmc.2016.05.053
CHEMBL3817911 147509 0 None -8 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 340 5 0 3 3.6 O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 10.1016/j.bmc.2016.05.053
CHEMBL4748908 220814 1 None -3 12 Human 6.5 pKi = 6.5 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL None None None CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1 10.6019/CHEMBL4800732
90656716 119490 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 340 6 0 5 2.9 CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262401 119490 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 340 6 0 5 2.9 CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304495 119490 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 340 6 0 5 2.9 CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1 10.1016/j.ejmech.2014.04.034
57393877 75204 0 None 1 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 5 3.4 O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917350 75204 0 None 1 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 5 3.4 O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1 10.1016/j.bmc.2011.09.044
71458516 87940 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 465 8 1 4 5.4 O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
CHEMBL2158031 87940 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 465 8 1 4 5.4 O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
57396857 78343 0 None 6 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 472 9 1 5 4.2 O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949971 78343 0 None 6 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 472 9 1 5 4.2 O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963101 78343 0 None 6 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 472 9 1 5 4.2 O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL4748908 220814 1 None -3 12 Human 6.5 pKi = 6.5 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL None None None CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1 10.6019/CHEMBL4800732
57390335 75193 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 387 9 1 4 2.5 NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917339 75193 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 387 9 1 4 2.5 NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
162669562 189481 0 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 6 0 4 4.2 O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4789472 189481 0 None -6 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 6 0 4 4.2 O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
57403841 78329 0 None 4 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949968 78329 0 None 4 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963030 78329 0 None 4 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
42618273 97975 0 None -223 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 461 3 0 4 4.1 O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2007.07.029
CHEMBL239899 97975 0 None -223 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 461 3 0 4 4.1 O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2007.07.029
10020040 106744 0 None -72 2 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 338 4 1 4 3.6 CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
CHEMBL28651 106744 0 None -72 2 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 338 4 1 4 3.6 CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
136118653 99829 0 None -6 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 332 1 2 2 2.3 C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C 10.1016/j.bmc.2013.09.011
CHEMBL2442267 99829 0 None -6 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 332 1 2 2 2.3 C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C 10.1016/j.bmc.2013.09.011
155544811 183330 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4567345 183330 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4597228 183330 0 None -5 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2019.06.028
60165411 82132 0 None -93 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 381 7 0 7 3.3 O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037529 82132 0 None -93 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 381 7 0 7 3.3 O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
71460454 88139 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 411 9 2 5 2.9 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159312 88139 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 411 9 2 5 2.9 CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1 10.1016/j.ejmech.2012.07.043
24768522 149354 0 None 2 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 462 9 2 4 4.5 CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL389110 149354 0 None 2 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 462 9 2 4 4.5 CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
12741423 113841 11 None -120 2 Rat 6.5 pKi = 6.5 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 261 6 0 2 3.7 CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
CHEMBL315684 113841 11 None -120 2 Rat 6.5 pKi = 6.5 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 261 6 0 2 3.7 CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
56852956 118820 1 None -87 9 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay
ChEMBL 339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289656 118820 1 None -87 9 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay
ChEMBL 339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.bmc.2014.04.026
44517733 201991 0 None 30 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 431 7 3 5 1.6 COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1 10.1016/j.bmcl.2009.06.038
CHEMBL550740 201991 0 None 30 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 431 7 3 5 1.6 COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1 10.1016/j.bmcl.2009.06.038
162648426 186739 0 None -7 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 373 6 0 3 4.6 Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1 10.1016/j.bmc.2020.115943
CHEMBL4746695 186739 0 None -7 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 373 6 0 3 4.6 Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1 10.1016/j.bmc.2020.115943
168299277 199474 0 None 281 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 404 8 0 5 4.2 CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1 10.1016/j.bmcl.2021.128275
CHEMBL5219333 199474 0 None 281 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 404 8 0 5 4.2 CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1 10.1016/j.bmcl.2021.128275
44460738 112230 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 291 3 0 3 2.9 CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL312049 112230 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 291 3 0 3 2.9 CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(02)00438-9
76332579 113052 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121423 113052 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3139019 113052 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
145976618 170558 0 None 8 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 468 8 1 4 4.7 CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4205806 170558 0 None 8 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 468 8 1 4 4.7 CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
90654836 119471 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 464 9 0 5 3.8 COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233667 119471 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 464 9 0 5 3.8 COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304308 119471 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 464 9 0 5 3.8 COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
155557134 181316 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 493 10 0 5 5.1 CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4555890 181316 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 493 10 0 5 5.1 CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmcl.2019.06.029
11186985 130624 0 None -11 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
CHEMBL362540 130624 0 None -11 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 307 6 0 1 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
134141985 153954 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3927929 153954 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
66801673 118851 0 None 8 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 468 7 1 6 3.6 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289969 118851 0 None 8 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 468 7 1 6 3.6 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
66801251 118897 0 None -13 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 507 7 1 6 5.4 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3290013 118897 0 None -13 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 507 7 1 6 5.4 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
122178704 128148 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 397 6 0 5 4.6 CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581249 128148 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 397 6 0 5 4.6 CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
44401106 131105 0 None -52 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL363581 131105 0 None -52 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
76284452 111782 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 492 11 1 6 3.7 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113594 111782 0 None 16 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 492 11 1 6 3.7 COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1 10.1016/j.bmc.2014.01.016
46204423 131341 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 259 3 1 2 3.4 Clc1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640570 131341 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 259 3 1 2 3.4 Clc1ccccc1-c1cccc(OC2CNC2)c1 nan
46204423 131341 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 259 3 1 2 3.4 Clc1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640570 131341 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 259 3 1 2 3.4 Clc1ccccc1-c1cccc(OC2CNC2)c1 nan
72550200 120853 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326980 120853 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1 10.1016/j.bmc.2014.07.026
72550423 120854 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326981 120854 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1 10.1016/j.bmc.2014.07.026
25107651 194489 0 None -4 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 412 10 1 5 3.8 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
CHEMBL495321 194489 0 None -4 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 412 10 1 5 3.8 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
44448054 101560 0 None -6 6 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL253318 101560 0 None -6 6 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
56852956 118820 1 None -87 9 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay
ChEMBL 339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289656 118820 1 None -87 9 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay
ChEMBL 339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 10.1016/j.bmc.2014.04.026
44404394 139593 0 None -30 7 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand
ChEMBL 443 4 1 5 3.5 COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 10.1016/j.bmcl.2005.07.024
CHEMBL370128 139593 0 None -30 7 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand
ChEMBL 443 4 1 5 3.5 COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 10.1016/j.bmcl.2005.07.024
168290061 198113 0 None -69 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 424 8 3 8 2.7 Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5191557 198113 0 None -69 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 424 8 3 8 2.7 Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1 10.1016/j.ejmech.2021.113931
162643558 190395 0 None -8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4777499 190395 0 None -8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4802310 190395 0 None -8 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 2 5 3.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
127026119 144513 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 8 1 5 2.7 COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759120 144513 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 8 1 5 2.7 COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
155562834 181985 0 None -10 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 450 8 0 5 4.1 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4571077 181985 0 None -10 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 450 8 0 5 4.1 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2019.06.029
72198011 96620 0 None -158 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
CHEMBL2377591 96620 0 None -158 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
72198011 96620 0 None -158 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2013.02.033
CHEMBL2377591 96620 0 None -158 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 498 8 2 4 5.2 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2013.02.033
13069622 127394 0 None -31 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 410 7 0 8 1.4 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360999 127394 0 None -31 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 410 7 0 8 1.4 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546120 127394 0 None -31 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 410 7 0 8 1.4 Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
168276829 196904 0 None -32 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.6 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5173329 196904 0 None -32 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.6 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
117209918 193189 1 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4876036 193189 1 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
155534153 183029 0 None -120 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 366 4 2 5 3.4 CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4469860 183029 0 None -120 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 366 4 2 5 3.4 CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4594878 183029 0 None -120 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 366 4 2 5 3.4 CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
117209918 193189 1 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4876036 193189 1 None 3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
168279625 197786 0 None -66 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 433 5 0 6 3.5 O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5186688 197786 0 None -66 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 433 5 0 6 3.5 O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12 10.1016/j.ejmech.2022.114319
71461049 89750 0 None -204 6 Human 5.5 pKi = 5.5 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 364 6 0 4 4.9 CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 10.1021/jm300943r
CHEMBL2181187 89750 0 None -204 6 Human 5.5 pKi = 5.5 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 364 6 0 4 4.9 CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 10.1021/jm300943r
118626208 172332 0 None -57 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4241830 172332 0 None -57 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
5640104 124717 11 None 1 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 429 4 1 5 3.4 NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1 10.1016/j.bmcl.2015.03.049
CHEMBL3403342 124717 11 None 1 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 429 4 1 5 3.4 NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1 10.1016/j.bmcl.2015.03.049
74538690 149842 0 None 10 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 511 10 1 4 5.2 O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3895172 149842 0 None 10 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 511 10 1 4 5.2 O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
164625711 193111 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 481 7 0 5 3.8 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4874914 193111 0 None -1 5 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 481 7 0 5 3.8 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
155535827 178896 0 None -2 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 450 6 1 2 6.5 Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.bmcl.2019.126769
CHEMBL4472767 178896 0 None -2 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 450 6 1 2 6.5 Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1016/j.bmcl.2019.126769
11278059 63789 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 302 3 1 2 4.2 Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644275 63789 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 302 3 1 2 4.2 Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
44439393 98584 0 None 2754 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 308 3 2 2 4.3 CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
CHEMBL241279 98584 0 None 2754 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 308 3 2 2 4.3 CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
44421337 144905 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1016/j.ejmech.2020.112437
CHEMBL376662 144905 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1016/j.ejmech.2020.112437
44421337 144905 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
CHEMBL376662 144905 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 437 8 1 5 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1 10.1021/jm049702f
44401105 76351 0 None -3 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 373 2 0 3 4.7 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL193435 76351 0 None -3 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 373 2 0 3 4.7 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 10.1021/jm049632c
132547277 148924 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 7 0 5 4.4 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3883542 148924 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 424 7 0 5 4.4 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.12.039
44324640 214201 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 281 3 2 4 3.0 COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
CHEMBL94017 214201 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 281 3 2 4 3.0 COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1 10.1016/s0960-894x(02)00925-3
60165535 82125 0 None -6 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 322 5 0 3 4.7 c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2 10.1016/j.ejmech.2012.03.042
CHEMBL2037522 82125 0 None -6 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 322 5 0 3 4.7 c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2 10.1016/j.ejmech.2012.03.042
162661940 188658 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 470 8 1 5 4.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4778946 188658 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 470 8 1 5 4.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
118728523 124496 0 None -5 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 5 4.0 O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401486 124496 0 None -5 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 410 7 0 5 4.0 O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
42625269 193587 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 292 3 0 2 2.6 O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1 10.1021/jm8014553
CHEMBL489256 193587 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 292 3 0 2 2.6 O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1 10.1021/jm8014553
44439388 98548 0 None 7 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 306 3 1 3 3.6 COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL241082 98548 0 None 7 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 306 3 1 3 3.6 COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1 10.1016/j.bmcl.2007.01.093
71450550 90582 0 None -7 16 Human 5.5 pKi = 5.5 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53 10.1016/j.bmcl.2012.08.046
CHEMBL2205836 90582 0 None -7 16 Human 5.5 pKi = 5.5 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53 10.1016/j.bmcl.2012.08.046
1355 8792 88 None -21 16 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm3003679
142 8792 88 None -21 16 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm3003679
CHEMBL478 8792 88 None -21 16 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm3003679
DB12110 8792 88 None -21 16 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 10.1021/jm3003679
57401516 75174 0 None -1 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 7 1 5 3.0 CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL1916746 75174 0 None -1 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 7 1 5 3.0 CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
156009734 183945 0 None 1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 393 5 2 4 3.7 COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4634426 183945 0 None 1 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 393 5 2 4 3.7 COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
9821832 133234 1 None -4 2 Rat 6.5 pKi = 6.5 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 391 6 0 5 2.7 COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL365201 133234 1 None -4 2 Rat 6.5 pKi = 6.5 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 391 6 0 5 2.7 COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
162671253 190537 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4792933 190537 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
CHEMBL4803811 190537 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2020.112437
168286403 198523 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.6 COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5197377 198523 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 501 6 0 7 4.6 COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
43229249 147595 1 None -91 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 279 5 0 2 3.7 O=C(CCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2016.05.053
CHEMBL3818989 147595 1 None -91 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 279 5 0 2 3.7 O=C(CCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2016.05.053
57402951 77243 0 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 413 6 0 5 5.1 O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL1946258 77243 0 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 413 6 0 5 5.1 O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
11261423 149177 0 None 7 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 445 8 2 4 4.4 O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL388970 149177 0 None 7 2 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 445 8 2 4 4.4 O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
118728507 124482 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 5 3.7 Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401470 124482 0 None -9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 1 5 3.7 Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
43229249 147595 1 None -91 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 279 5 0 2 3.7 O=C(CCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2016.05.053
CHEMBL3818989 147595 1 None -91 8 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 279 5 0 2 3.7 O=C(CCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2016.05.053
44393074 71051 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL180946 71051 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
137644790 164847 0 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4086211 164847 0 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
162664377 188977 0 None 75 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 533 9 1 6 6.3 COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4782879 188977 0 None 75 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 533 9 1 6 6.3 COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
156012551 184116 0 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 470 8 0 5 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4637294 184116 0 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 470 8 0 5 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
138691321 181298 0 None 18 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 355 2 1 2 3.8 CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4555349 181298 0 None 18 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 355 2 1 2 3.8 CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12 10.1016/j.ejmech.2019.03.017
127039754 143460 0 None 10 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 454 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1 10.1039/C5MD00166H
CHEMBL3740302 143460 0 None 10 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 454 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1 10.1039/C5MD00166H
164619290 192584 0 None -2 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 463 7 0 5 4.0 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4866981 192584 0 None -2 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 463 7 0 5 4.0 O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.bmcl.2021.128028
57391624 78344 0 None 3 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1949972 78344 0 None 3 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1963102 78344 0 None 3 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12 10.1016/j.bmc.2011.12.039
11404955 63800 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 336 3 0 2 4.8 CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
CHEMBL1644488 63800 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 336 3 0 2 4.8 CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
44439391 151897 0 None 52 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 336 3 2 4 3.3 COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.01.093
CHEMBL391190 151897 0 None 52 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 336 3 2 4 3.3 COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.01.093
118709752 120319 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 362 8 0 2 4.6 O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL3321793 120319 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 362 8 0 2 4.6 O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1 10.1021/jm500880c
11463465 73652 0 None -7 2 Rat 7.4 pKi = 7.4 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 391 6 0 5 2.7 COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL186334 73652 0 None -7 2 Rat 7.4 pKi = 7.4 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 391 6 0 5 2.7 COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
10807321 105945 0 None 3 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 343 1 2 3 4.5 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3 10.1021/jm0108505
CHEMBL281273 105945 0 None 3 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 343 1 2 3 4.5 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3 10.1021/jm0108505
118713587 121148 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 367 6 0 5 3.7 O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331255 121148 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 367 6 0 5 3.7 O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
134151729 160224 0 None 5 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.7 C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
CHEMBL3979307 160224 0 None 5 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 455 10 1 3 5.7 C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1 10.1016/j.ejmech.2016.05.005
72550196 120852 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326979 120852 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 475 10 1 4 5.1 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2014.07.026
155524374 177699 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4455118 177699 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.06.080
11429236 132196 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 390 8 1 5 2.4 COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1 10.1021/jm049743b
CHEMBL364557 132196 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 390 8 1 5 2.4 COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1 10.1021/jm049743b
57395597 75184 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 410 7 1 4 3.6 COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2 10.1016/j.bmc.2011.09.044
CHEMBL1917330 75184 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 410 7 1 4 3.6 COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2 10.1016/j.bmc.2011.09.044
145964159 171108 0 None -77 6 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 273 3 2 4 2.6 C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1 10.1021/acs.jnatprod.7b00317
CHEMBL4212435 171108 0 None -77 6 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 273 3 2 4 2.6 C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1 10.1021/acs.jnatprod.7b00317
44439410 154067 0 None 5 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 280 4 1 2 3.5 CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1 10.1016/j.bmcl.2007.01.093
CHEMBL392888 154067 0 None 5 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 280 4 1 2 3.5 CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1 10.1016/j.bmcl.2007.01.093
44439407 174194 0 None -11 3 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 424 8 0 4 5.9 CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL429644 174194 0 None -11 3 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 424 8 0 4 5.9 CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
71459604 90568 0 None -6 14 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 10.1016/j.bmcl.2012.08.046
CHEMBL2205811 90568 0 None -6 14 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 10.1016/j.bmcl.2012.08.046
145979626 173320 0 None 1 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 454 6 2 5 1.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4279397 173320 0 None 1 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 454 6 2 5 1.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
118736371 125721 0 None -9 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 483 6 0 9 2.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2015.04.046
CHEMBL3423335 125721 0 None -9 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 483 6 0 9 2.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2015.04.046
118724643 127380 0 None -8 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 353 4 0 7 0.9 Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3361002 127380 0 None -8 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 353 4 0 7 0.9 Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3545933 127380 0 None -8 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 353 4 0 7 0.9 Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
122483213 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764178 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765841 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
135367399 170614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4206411 170614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
118736370 125720 0 None -50 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 483 7 0 9 2.3 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423334 125720 0 None -50 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 483 7 0 9 2.3 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
122483213 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764178 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765841 144871 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
27620 147596 13 None -158 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 297 5 0 2 3.8 O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818994 147596 13 None -158 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 297 5 0 2 3.8 O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 10.1016/j.bmc.2016.05.053
11209976 129951 0 None 1 3 Rat 6.4 pKi = 6.4 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
CHEMBL361287 129951 0 None 1 3 Rat 6.4 pKi = 6.4 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 339 7 0 3 4.8 CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1 10.1021/jm0498102
71455894 90577 0 None -3 12 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmcl.2012.08.046
CHEMBL2205827 90577 0 None -3 12 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmcl.2012.08.046
71455894 90577 0 None -3 12 Human 5.4 pKi = 5.4 Binding
Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmc.2013.07.045
CHEMBL2205827 90577 0 None -3 12 Human 5.4 pKi = 5.4 Binding
Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmc.2013.07.045
135398745 9688 112 None -95 65 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm049632c
47 9688 112 None -95 65 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm049632c
CHEMBL715 9688 112 None -95 65 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm049632c
DB00334 9688 112 None -95 65 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm049632c
162644116 190399 0 None -4 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 1 5 3.3 COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4778021 190399 0 None -4 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 1 5 3.3 COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4802344 190399 0 None -4 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 411 10 1 5 3.3 COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
155552054 180790 0 None -7 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 443 9 0 4 5.2 COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1 10.1016/j.bmcl.2019.06.029
CHEMBL4542754 180790 0 None -7 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 443 9 0 4 5.2 COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1 10.1016/j.bmcl.2019.06.029
155534312 178696 0 None 2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 445 8 1 4 5.8 O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4469984 178696 0 None 2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 445 8 1 4 5.8 O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
135367399 170614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4206411 170614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
136116062 104456 0 None -10 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL271253 104456 0 None -10 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21 10.1016/j.bmcl.2007.10.078
44391586 173123 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmcl.2004.11.013
CHEMBL427326 173123 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2 10.1016/j.bmcl.2004.11.013
44395817 73573 0 None 1 2 Rat 6.4 pKi = 6.4 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 441 6 0 5 3.8 COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL185988 73573 0 None 1 2 Rat 6.4 pKi = 6.4 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 441 6 0 5 3.8 COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1 10.1016/j.bmcl.2004.09.029
44424670 92500 0 None -14 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 446 6 1 8 1.0 Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
CHEMBL228940 92500 0 None -14 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 446 6 1 8 1.0 Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2007.05.017
135367821 170671 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4207073 170671 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
137636384 162730 0 None -741 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 356 4 0 4 2.5 CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23 10.1021/acsmedchemlett.6b00482
CHEMBL4061189 162730 0 None -741 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 356 4 0 4 2.5 CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23 10.1021/acsmedchemlett.6b00482
11166042 173148 0 None 2 3 Human 7.4 pKi = 7.4 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2019.111705
CHEMBL427518 173148 0 None 2 3 Human 7.4 pKi = 7.4 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.ejmech.2019.111705
44461069 212374 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 377 5 0 3 4.1 CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL81488 212374 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 377 5 0 3 4.1 CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1 10.1016/s0960-894x(02)00438-9
122181338 128658 0 None -2 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 466 6 1 4 4.0 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590090 128658 0 None -2 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 466 6 1 4 4.0 O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
137650705 164013 0 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4076408 164013 0 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
137645926 164344 0 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4080398 164344 0 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2017.04.046
57395599 75211 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
CHEMBL1917357 75211 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
156016366 184418 0 None -4 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 458 10 1 6 4.0 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1 10.1016/j.bmc.2020.115459
CHEMBL4641296 184418 0 None -4 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 458 10 1 6 4.0 O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1 10.1016/j.bmc.2020.115459
134130247 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3890153 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3991291 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
44374233 58302 2 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
CHEMBL158285 58302 2 None 3 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
118736373 125723 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 545 7 0 9 3.6 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423337 125723 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 545 7 0 9 3.6 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
135398737 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/np500893h
38 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/np500893h
722 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/np500893h
CHEMBL42 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/np500893h
DB00363 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/np500893h
44437334 157277 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 694 18 0 9 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL395444 157277 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 694 18 0 9 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
44266178 105142 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 403 4 0 3 3.1 O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL275258 105142 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 403 4 0 3 3.1 O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1 10.1016/s0960-894x(03)00077-5
134130247 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3890153 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3991291 161354 0 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 308 4 0 3 4.3 c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 10.1016/j.bmc.2016.09.019
72549986 120600 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 457 10 1 4 5.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3325464 120600 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 457 10 1 4 5.0 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
53316914 63802 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 364 4 0 2 5.6 CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
CHEMBL1644490 63802 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 364 4 0 2 5.6 CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1 10.1016/j.bmcl.2010.11.078
9927441 214173 0 None -1096 9 Human 5.4 pKi = 5.4 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1021/jm010943m
CHEMBL93868 214173 0 None -1096 9 Human 5.4 pKi = 5.4 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1021/jm010943m
17055181 169231 1 None 1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 409 7 1 2 6.2 Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL4166667 169231 1 None 1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 409 7 1 2 6.2 Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1 10.1016/j.ejmech.2018.04.010
155547436 180351 0 None -7 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 471 9 0 5 4.8 COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 10.1016/j.bmcl.2019.06.029
CHEMBL4532741 180351 0 None -7 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 471 9 0 5 4.8 COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 10.1016/j.bmcl.2019.06.029
168278783 197509 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 467 6 0 7 3.9 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5182578 197509 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 467 6 0 7 3.9 COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
135367821 170671 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4207073 170671 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
155521504 183374 0 None -416 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.ejmech.2019.06.001
CHEMBL4451939 183374 0 None -416 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.ejmech.2019.06.001
CHEMBL4597600 183374 0 None -416 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 432 4 2 6 4.3 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1 10.1016/j.ejmech.2019.06.001
164618208 192164 0 None -371 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 467 6 0 5 3.7 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4860626 192164 0 None -371 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 467 6 0 5 3.7 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
3132842 169766 9 None -10 3 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 411 9 1 4 5.4 CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1 10.1016/j.ejmech.2018.04.010
CHEMBL4175296 169766 9 None -10 3 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 411 9 1 4 5.4 CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1 10.1016/j.ejmech.2018.04.010
155516282 176848 0 None -20 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 443 9 0 4 5.2 COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1 10.1016/j.bmcl.2019.06.029
CHEMBL4443185 176848 0 None -20 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 443 9 0 4 5.2 COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1 10.1016/j.bmcl.2019.06.029
CHEMBL5281673 200901 0 None -47 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 643 12 0 8 5.8 O=C1CC2Cc3ccsc3C2=NN1CCCCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2023.117256
122181343 128663 0 None -17 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 528 7 1 4 5.3 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590095 128663 0 None -17 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 528 7 1 4 5.3 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
122483292 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764335 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765876 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
57392108 75208 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917354 75208 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
145971561 171288 0 None 7 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 444 4 1 4 3.7 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4214709 171288 0 None 7 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 444 4 1 4 3.7 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2 10.1016/j.bmcl.2018.06.019
122483292 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764335 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765876 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
56945046 118837 0 None -6 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 500 7 1 6 4.6 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3289955 118837 0 None -6 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 500 7 1 6 4.6 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
122178706 128150 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 425 8 0 5 5.4 CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581251 128150 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 425 8 0 5 5.4 CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
42618264 188258 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 394 8 1 5 3.3 COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL476464 188258 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 394 8 1 5 3.3 COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL5090557 222049 0 None -54 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3s2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
162665588 189175 0 None -85 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 10.1016/j.ejmech.2020.112149
CHEMBL4785434 189175 0 None -85 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 10.1016/j.ejmech.2020.112149
122483292 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764335 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765876 144889 0 None -1 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 441 7 1 5 5.5 O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
10610641 105695 0 None -2 5 Rat 7.4 pKi = 7.4 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 249 0 0 1 3.7 Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm9911433
CHEMBL27940 105695 0 None -2 5 Rat 7.4 pKi = 7.4 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 249 0 0 1 3.7 Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm9911433
11466615 144829 0 None 2 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
CHEMBL376531 144829 0 None 2 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
135458428 162313 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 255 3 2 4 2.2 COc1cccc2c1N=C(NCC(F)F)NC2C 10.1016/j.bmcl.2007.10.078
CHEMBL404248 162313 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 255 3 2 4 2.2 COc1cccc2c1N=C(NCC(F)F)NC2C 10.1016/j.bmcl.2007.10.078
66801701 166108 0 None -6 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 471 8 2 3 5.3 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4099997 166108 0 None -6 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 471 8 2 3 5.3 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
155521010 177371 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 572 9 1 6 5.4 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4450652 177371 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 572 9 1 6 5.4 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
90644075 118856 0 None -6 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 8 1 7 3.2 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289973 118856 0 None -6 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 484 8 1 7 3.2 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
46206026 131384 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 2 1 1 4.5 Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F nan
CHEMBL3640611 131384 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 2 1 1 4.5 Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F nan
46206026 131384 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 2 1 1 4.5 Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F nan
CHEMBL3640611 131384 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 2 1 1 4.5 Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F nan
2927683 168981 9 None -2 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 353 8 1 2 6.0 CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL4162688 168981 9 None -2 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 353 8 1 2 6.0 CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1 10.1016/j.ejmech.2018.04.010
146025727 178464 0 None -141 27 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4466483 178464 0 None -141 27 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
155536152 178918 0 None -29 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 368 4 1 7 2.1 CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4473083 178918 0 None -29 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 368 4 1 7 2.1 CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
57396855 78249 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949969 78249 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1962400 78249 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1 10.1016/j.bmc.2011.12.039
118736375 125725 0 None -14 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 477 6 0 9 2.2 Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C 10.1016/j.ejmech.2015.04.046
CHEMBL3423339 125725 0 None -14 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 477 6 0 9 2.2 Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C 10.1016/j.ejmech.2015.04.046
71461050 89752 0 None -123 5 Human 6.4 pKi = 6.4 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 352 5 0 3 5.0 CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 10.1021/jm300943r
CHEMBL2181189 89752 0 None -123 5 Human 6.4 pKi = 6.4 Binding
Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay
ChEMBL 352 5 0 3 5.0 CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 10.1021/jm300943r
10971846 57267 0 None -1 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 420 8 1 4 5.0 O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL157362 57267 0 None -1 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 420 8 1 4 5.0 O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O 10.1021/jm020994z
139488518 176776 0 None 14 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 229 2 1 2 3.2 CCn1cncc1-c1c[nH]c2cccc(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4442337 176776 0 None 14 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 229 2 1 2 3.2 CCn1cncc1-c1c[nH]c2cccc(F)c12 10.1016/j.ejmech.2019.03.017
135367936 171252 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4214171 171252 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
156017609 184680 0 None -19 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 464 9 1 6 4.9 O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1 10.1016/j.bmc.2020.115459
CHEMBL4644906 184680 0 None -19 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 464 9 1 6 4.9 O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1 10.1016/j.bmc.2020.115459
155519102 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4447416 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
155519102 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4447416 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
155519102 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
CHEMBL4447416 177134 0 None -371 5 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
1220 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2016.06.080
31 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2016.06.080
7 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2016.06.080
CHEMBL56 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2016.06.080
1220 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmc.2016.12.039
31 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmc.2016.12.039
7 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmc.2016.12.039
CHEMBL56 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmc.2016.12.039
1220 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2015.02.042
31 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2015.02.042
7 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2015.02.042
CHEMBL56 6975 55 None -208 44 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.bmcl.2015.02.042
145946527 174349 0 None -10 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 10 0 4 3.6 Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C 10.1016/j.bmcl.2018.04.059
CHEMBL4217761 174349 0 None -10 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 10 0 4 3.6 Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C 10.1016/j.bmcl.2018.04.059
CHEMBL4300609 174349 0 None -10 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 382 10 0 4 3.6 Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C 10.1016/j.bmcl.2018.04.059
134155651 157909 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 329 4 0 2 5.2 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
CHEMBL3959382 157909 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 329 4 0 2 5.2 COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
25107652 194191 0 None -20 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 396 10 1 5 3.1 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
CHEMBL493709 194191 0 None -20 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 396 10 1 5 3.1 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
142601325 192648 0 None 3 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4868035 192648 0 None 3 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
135367936 171252 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4214171 171252 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
137655411 165535 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4093971 165535 0 None -1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmc.2017.04.046
127026147 144517 0 None 12 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 417 8 2 5 3.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759161 144517 0 None 12 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 417 8 2 5 3.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1 10.1016/j.ejmech.2015.11.040
156014041 183987 0 None -2 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2020.115459
CHEMBL4635363 183987 0 None -2 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 443 8 0 4 4.1 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2020.115459
90656700 119461 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 417 9 1 4 5.4 CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3259846 119461 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 417 9 1 4 5.4 CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304188 119461 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 417 9 1 4 5.4 CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
90656687 117761 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 402 8 1 5 2.7 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262417 117761 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 402 8 1 5 2.7 CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1 10.1016/j.ejmech.2014.04.034
145 6928 49 None -4 30 Rat 7.4 pKi = 7.4 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030826m
1832 6928 49 None -4 30 Rat 7.4 pKi = 7.4 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030826m
CHEMBL7257 6928 49 None -4 30 Rat 7.4 pKi = 7.4 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030826m
DB14010 6928 49 None -4 30 Rat 7.4 pKi = 7.4 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm030826m
49850570 63246 0 None -251 9 Human 7.4 pKi = 7.4 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 417 6 2 4 4.0 CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
CHEMBL1632220 63246 0 None -251 9 Human 7.4 pKi = 7.4 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 417 6 2 4 4.0 CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
44343212 16610 0 None 50 3 Human 7.4 pKi = 7.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
CHEMBL114012 16610 0 None 50 3 Human 7.4 pKi = 7.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
135398737 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2010.03.012
38 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2010.03.012
722 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2010.03.012
CHEMBL42 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2010.03.012
DB00363 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2010.03.012
9934284 97071 0 None -100 10 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL238520 97071 0 None -100 10 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
44439165 152531 0 None -15 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL391661 152531 0 None -15 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
11475386 129410 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 410 7 1 4 3.6 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2 10.1021/jm049743b
CHEMBL360382 129410 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 410 7 1 4 3.6 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2 10.1021/jm049743b
156022135 184997 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 341 6 0 1 6.0 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
CHEMBL4649788 184997 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 341 6 0 1 6.0 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
4223 10764 94 None -81 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1016/j.bmcl.2019.126703
6918314 10764 94 None -81 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1016/j.bmcl.2019.126703
7427 10764 94 None -81 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1016/j.bmcl.2019.126703
CHEMBL439849 10764 94 None -81 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1016/j.bmcl.2019.126703
DB06684 10764 94 None -81 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
ChEMBL 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 10.1016/j.bmcl.2019.126703
76332583 113192 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 319 3 0 3 3.7 Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121439 113192 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 319 3 0 3 3.7 Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139517 113192 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 319 3 0 3 3.7 Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
71453157 87947 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 1 3 4.8 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2158038 87947 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 418 7 1 3 4.8 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
162676059 190565 0 None -2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 4.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4796573 190565 0 None -2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 4.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4804095 190565 0 None -2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 4.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
142601325 192648 0 None 3 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4868035 192648 0 None 3 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 242 2 2 3 1.9 c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 10.1021/acs.jmedchem.1c01093
90654679 116877 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 468 8 1 4 3.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235751 116877 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 468 8 1 4 3.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2014.03.005
156017397 184476 0 None -1 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 420 7 1 4 5.0 CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
CHEMBL4642034 184476 0 None -1 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 420 7 1 4 5.0 CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
16117151 66861 0 None -3981 7 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 390 4 3 5 3.2 O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 10.1016/j.bmc.2010.10.033
CHEMBL1642882 66861 0 None -3981 7 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 390 4 3 5 3.2 O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 10.1016/j.bmc.2010.10.033
CHEMBL1739102 66861 0 None -3981 7 Human 5.4 pKi = 5.4 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 390 4 3 5 3.2 O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 10.1016/j.bmc.2010.10.033
127026052 144331 0 None -23 19 Human 6.4 pKi = 6.4 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 258 7 1 1 3.5 C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3754496 144331 0 None -23 19 Human 6.4 pKi = 6.4 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 258 7 1 1 3.5 C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 10.1016/j.bmcl.2015.12.053
10715998 52002 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
CHEMBL152595 52002 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 400 5 0 3 4.5 CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
10596321 214243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
CHEMBL94261 214243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm991151j
11281062 126435 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 401 6 0 4 4.0 COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
CHEMBL346906 126435 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 401 6 0 4 4.0 COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
147653864 178340 0 None -19 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 267 0 1 2 2.7 C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4464697 178340 0 None -19 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 267 0 1 2 2.7 C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
11168182 10307 25 None -630 13 Human 5.4 pKi = 5.4 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 511 14 1 3 6.5 CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C 10.1016/j.bmcl.2005.06.024
264 10307 25 None -630 13 Human 5.4 pKi = 5.4 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 511 14 1 3 6.5 CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C 10.1016/j.bmcl.2005.06.024
CHEMBL1181770 10307 25 None -630 13 Human 5.4 pKi = 5.4 Binding
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
ChEMBL 511 14 1 3 6.5 CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C 10.1016/j.bmcl.2005.06.024
276 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1021/jm980532e
5312149 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1021/jm980532e
CHEMBL431298 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1021/jm980532e
276 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/s0960-894x(02)00172-5
5312149 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/s0960-894x(02)00172-5
CHEMBL431298 10286 50 None -100 13 Human 5.4 pKi = 5.4 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 451 5 2 6 4.1 COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl 10.1016/s0960-894x(02)00172-5
44393007 73067 0 None 120 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL184789 73067 0 None 120 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 351 8 2 4 4.9 C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393229 73471 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL185512 73471 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 335 7 2 3 5.0 C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393004 128952 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL359725 128952 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 333 8 2 4 4.7 C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1 10.1016/j.bmcl.2004.06.007
5 6927 72 None -3 53 Human 8.4 pKi = 8.4 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
5202 6927 72 None -3 53 Human 8.4 pKi = 8.4 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
CHEMBL39 6927 72 None -3 53 Human 8.4 pKi = 8.4 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
DB08839 6927 72 None -3 53 Human 8.4 pKi = 8.4 Binding
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
145965054 171068 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 472 7 2 4 3.8 CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21 10.1021/acs.jmedchem.7b01898
CHEMBL4211987 171068 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 472 7 2 4 3.8 CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21 10.1021/acs.jmedchem.7b01898
9956365 202297 0 None 34 3 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm030030n
CHEMBL553794 202297 0 None 34 3 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 470 7 2 4 4.1 CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm030030n
76320705 110316 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 1 0 2 5.2 CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm049743b
CHEMBL3085301 110316 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 352 1 0 2 5.2 CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm049743b
4106 9280 22 None -2 33 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
5358812 9280 22 None -2 33 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
89 9280 22 None -2 33 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
CHEMBL93240 9280 22 None -2 33 Rat 8.4 pKi = 8.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1021/jm030030n
127024951 144418 0 None 51 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 4.8 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3758286 144418 0 None 51 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 4 4.8 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1 10.1016/j.ejmech.2015.11.040
127026131 144528 0 None 12 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 464 8 1 4 4.4 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759233 144528 0 None 12 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 464 8 1 4 4.4 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1 10.1016/j.ejmech.2015.11.040
118626101 172503 0 None -1 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4245997 172503 0 None -1 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
118626142 172599 0 None 1 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4248491 172599 0 None 1 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 506 6 0 6 4.8 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
71453281 88217 0 None 6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159485 88217 0 None 6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1 10.1016/j.ejmech.2012.07.043
71451460 88220 0 None 9 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 5 4.5 O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159488 88220 0 None 9 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 462 8 1 5 4.5 O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
139488606 177536 1 None 147 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 355 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4452569 177536 1 None 147 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 355 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12 10.1016/j.ejmech.2019.03.017
54758295 72774 0 None 13 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 378 7 1 4 3.7 CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL1836789 72774 0 None 13 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 378 7 1 4 3.7 CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
118706732 127305 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 295 1 3 2 1.6 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
CHEMBL3310713 127305 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 295 1 3 2 1.6 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
CHEMBL3545445 127305 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 295 1 3 2 1.6 Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O 10.1016/j.bmc.2014.05.027
44374233 58302 2 None 3 5 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmcl.2003.11.050
CHEMBL158285 58302 2 None 3 5 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmcl.2003.11.050
44374233 58302 2 None 3 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
CHEMBL158285 58302 2 None 3 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
ChEMBL 260 4 0 3 2.5 CN(C)CCSc1cccc(Br)n1 10.1016/j.bmc.2010.01.035
118706285 119665 0 None -2 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 295 2 3 2 1.7 CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
CHEMBL3310113 119665 0 None -2 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 295 2 3 2 1.7 CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
118706301 127316 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 265 1 2 1 2.2 CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3310122 127316 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 265 1 2 1 2.2 CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3545473 127316 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 265 1 2 1 2.2 CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
66801455 118846 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 470 8 1 8 2.8 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
CHEMBL3289964 118846 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 470 8 1 8 2.8 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
66801062 118895 0 None -4 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 6 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3290011 118895 0 None -4 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 473 7 1 6 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
11282296 150093 0 None -1 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL389718 150093 0 None -1 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
135458427 178332 0 None 5 5 Human 8.4 pKi = 8.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 283 4 2 4 3.0 CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C 10.1016/j.bmcl.2007.10.078
CHEMBL446459 178332 0 None 5 5 Human 8.4 pKi = 8.4 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 283 4 2 4 3.0 CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C 10.1016/j.bmcl.2007.10.078
118524962 184448 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
CHEMBL4641654 184448 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
11694810 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3310123 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
CHEMBL3545474 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.09.005
10707685 169732 0 None 6 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 277 0 1 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O 10.1021/jm9911433
CHEMBL417473 169732 0 None 6 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 277 0 1 2 3.0 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O 10.1021/jm9911433
11694810 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3310123 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
CHEMBL3545474 127317 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 10.1016/j.bmc.2014.05.027
66801225 118894 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 10.1021/jm401895u
CHEMBL3290010 118894 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 10.1021/jm401895u
2389 10104 118 None -8 66 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm049632c
5073 10104 118 None -8 66 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm049632c
96 10104 118 None -8 66 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm049632c
CHEMBL85 10104 118 None -8 66 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm049632c
DB00734 10104 118 None -8 66 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1021/jm049632c
44388858 68271 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL177064 68271 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2009.02.008
11566558 166235 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 354 6 1 3 4.6 CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL410128 166235 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 354 6 1 3 4.6 CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21 10.1021/jm070279v
109018769 182067 1 None -12 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 337 7 1 3 2.5 O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1 10.1016/j.bmcl.2016.06.080
CHEMBL4572955 182067 1 None -12 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 337 7 1 3 2.5 O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1 10.1016/j.bmcl.2016.06.080
56944191 118879 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 483 8 1 5 4.7 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3289996 118879 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 483 8 1 5 4.7 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
46206347 131337 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 4 1 3 3.4 COc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
CHEMBL3640566 131337 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 4 1 3 3.4 COc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
46206347 131337 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 4 1 3 3.4 COc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
CHEMBL3640566 131337 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 4 1 3 3.4 COc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
22449331 113712 0 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 360 5 1 2 4.4 O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL314830 113712 0 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 360 5 1 2 4.4 O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
44266156 105179 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 382 5 0 3 3.8 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL275451 105179 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 382 5 0 3 3.8 O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1 10.1016/s0960-894x(03)00077-5
11662592 79119 0 None -3 9 Human 8.4 pKi = 8.4 Binding
Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor
ChEMBL 460 4 0 8 2.8 CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 10.1016/j.bmcl.2005.04.077
CHEMBL198463 79119 0 None -3 9 Human 8.4 pKi = 8.4 Binding
Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor
ChEMBL 460 4 0 8 2.8 CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 10.1016/j.bmcl.2005.04.077
76321735 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2019.111705
CHEMBL3121424 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2019.111705
CHEMBL3139441 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2019.111705
76321735 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121424 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139441 113173 0 None 15 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 447 5 0 4 6.1 COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
134156520 160894 0 None 8 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 501 13 1 5 5.3 COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3985152 160894 0 None 8 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 501 13 1 5 5.3 COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
156013673 184040 0 None 10 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 293 1 2 2 2.9 CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4636148 184040 0 None 10 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 293 1 2 2 2.9 CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 10.1016/j.bmc.2020.115578
66800916 118844 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 518 8 1 7 4.8 Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
CHEMBL3289962 118844 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 518 8 1 7 4.8 Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12 10.1021/jm401895u
44388858 68271 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2005.05.059
CHEMBL177064 68271 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2005.05.059
44388858 68271 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2007.03.054
CHEMBL177064 68271 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 361 5 0 4 4.1 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1 10.1016/j.bmcl.2007.03.054
24854043 102676 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21 10.1021/jm070279v
CHEMBL259215 102676 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21 10.1021/jm070279v
10971401 109473 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 400 6 1 2 5.5 Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1021/jm0104264
CHEMBL304731 109473 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 400 6 1 2 5.5 Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1 10.1021/jm0104264
164609172 191186 0 None 10 5 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 378 6 1 5 2.8 O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4845947 191186 0 None 10 5 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 378 6 1 5 2.8 O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
162674129 189992 0 None -10 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4795995 189992 0 None -10 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 10.1016/j.ejmech.2020.112149
164609172 191186 0 None 10 5 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 378 6 1 5 2.8 O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4845947 191186 0 None 10 5 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 378 6 1 5 2.8 O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
44437331 97738 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 734 21 0 8 8.2 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239530 97738 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 734 21 0 8 8.2 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
135339817 188263 0 None 1 7 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 437 6 0 5 4.2 CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O 10.1016/j.ejmech.2020.112709
CHEMBL4764679 188263 0 None 1 7 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 437 6 0 5 4.2 CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O 10.1016/j.ejmech.2020.112709
11687730 127363 0 None -9 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 277 1 2 1 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343668 127363 0 None -9 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 277 1 2 1 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3545816 127363 0 None -9 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 277 1 2 1 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
127024950 144569 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 412 8 1 6 2.1 Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1 10.1016/j.ejmech.2015.11.040
CHEMBL3759558 144569 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 412 8 1 6 2.1 Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1 10.1016/j.ejmech.2015.11.040
118731360 124974 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 544 9 0 4 5.5 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409043 124974 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 544 9 0 4 5.5 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
162668650 189452 0 None -13 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 284 3 2 4 2.9 CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4789085 189452 0 None -13 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 284 3 2 4 2.9 CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
57396419 78317 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1949976 78317 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1962961 78317 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
82187974 119458 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 296 5 1 3 3.1 Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262406 119458 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 296 5 1 3 3.1 Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304139 119458 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 296 5 1 3 3.1 Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
135398737 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
38 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
722 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
CHEMBL42 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
DB00363 7745 93 None -13 90 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
11532105 72777 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 432 6 1 2 5.8 O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm200547z
CHEMBL1836792 72777 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 432 6 1 2 5.8 O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm200547z
54758391 72784 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
CHEMBL1836859 72784 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
23369416 189266 2 None -3 3 Human 7.4 pKi = 7.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 366 6 1 5 2.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL478680 189266 2 None -3 3 Human 7.4 pKi = 7.4 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 366 6 1 5 2.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
155512406 176420 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 449 7 1 5 5.6 O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4437211 176420 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 449 7 1 5 5.6 O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
11385992 91443 0 None 1 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 439 8 1 3 5.2 O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL222477 91443 0 None 1 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 439 8 1 3 5.2 O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
2389 10104 118 None -7 66 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2020.112709
5073 10104 118 None -7 66 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2020.112709
96 10104 118 None -7 66 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2020.112709
CHEMBL85 10104 118 None -7 66 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2020.112709
DB00734 10104 118 None -7 66 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1016/j.ejmech.2020.112709
44324643 214015 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 311 4 2 5 3.1 COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1 10.1016/s0960-894x(02)00925-3
CHEMBL92856 214015 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 311 4 2 5 3.1 COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1 10.1016/s0960-894x(02)00925-3
10596321 214243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030030n
CHEMBL94261 214243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 10.1021/jm030030n
156010130 183818 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 319 2 0 1 5.1 CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4632499 183818 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 319 2 0 1 5.1 CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1 10.1016/j.bmc.2019.115262
59752589 186605 0 None -26 4 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 4.1 CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4745055 186605 0 None -26 4 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 4.1 CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2 10.1016/j.bmcl.2020.127669
44439398 97988 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 5 0 5 4.4 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL240022 97988 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 5 0 5 4.4 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2 10.1016/j.bmcl.2007.01.093
9950396 151901 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 4 1 4 3.4 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL391192 151901 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 352 4 1 4 3.4 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2 10.1016/j.bmcl.2007.01.093
59752584 188274 0 None -128 4 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 4.1 CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4764808 188274 0 None -128 4 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 323 2 1 3 4.1 CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2 10.1016/j.bmcl.2020.127669
155519045 177105 0 None 2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 446 8 1 5 4.7 O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4446978 177105 0 None 2 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 446 8 1 5 4.7 O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
118464420 145023 0 None -67 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 335 1 3 5 2.8 NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1 10.1021/acs.jmedchem.5b01631
CHEMBL3770342 145023 0 None -67 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 335 1 3 5 2.8 NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1 10.1021/acs.jmedchem.5b01631
53361627 73403 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1812288 73403 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1852767 73403 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2011.04.060
155545088 183436 0 None -5 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4528793 183436 0 None -5 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4598089 183436 0 None -5 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 6.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
72550864 120856 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326983 120856 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1 10.1016/j.bmc.2014.07.026
71462066 87941 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 8 1 4 4.4 CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158032 87941 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 386 8 1 4 4.4 CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1 10.1016/j.ejmech.2012.07.043
1353 8692 93 None -263 85 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.ejmech.2018.01.002
3559 8692 93 None -263 85 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.ejmech.2018.01.002
86 8692 93 None -263 85 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.ejmech.2018.01.002
CHEMBL54 8692 93 None -263 85 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.ejmech.2018.01.002
DB00502 8692 93 None -263 85 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.ejmech.2018.01.002
145975713 170721 0 None 10 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 472 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.8b00828
CHEMBL4207633 170721 0 None 10 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 472 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.8b00828
71451344 87938 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 3 4.4 Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158029 87938 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 406 7 1 3 4.4 Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1 10.1016/j.ejmech.2012.07.043
56851049 78278 0 None -21 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926734 78278 0 None -21 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962693 78278 0 None -21 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1 10.1021/jm2007886
76328892 113191 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 392 4 0 4 4.8 N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121429 113191 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 392 4 0 4 4.8 N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139511 113191 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 392 4 0 4 4.8 N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
57390337 75210 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917356 75210 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 482 10 0 6 3.9 CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1 10.1016/j.bmc.2011.09.044
71462178 88201 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 437 7 1 4 4.8 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
CHEMBL2159469 88201 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 437 7 1 4 4.8 O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
71574298 93060 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 526 8 1 5 5.1 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312936 93060 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 526 8 1 5 5.1 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.ejmech.2012.11.042
145976158 170621 0 None 53 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4206468 170621 0 None 53 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
118706278 127301 0 None -26 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310109 127301 0 None -26 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545439 127301 0 None -26 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 301 1 3 2 1.8 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2 10.1016/j.bmc.2014.05.027
118706292 127312 0 None -6 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 297 2 4 3 0.7 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310117 127312 0 None -6 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 297 2 4 3 0.7 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545469 127312 0 None -6 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 297 2 4 3 0.7 NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2 10.1016/j.bmc.2014.05.027
118709754 120322 0 None 12 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 340 6 0 2 4.3 O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321796 120322 0 None 12 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 340 6 0 2 4.3 O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
66801116 118871 0 None 81 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 457 7 1 8 2.9 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3289988 118871 0 None 81 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 457 7 1 8 2.9 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
11785995 91127 0 None -1 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
CHEMBL221732 91127 0 None -1 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2 10.1021/jm049702f
44437327 97642 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 650 15 0 8 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239231 97642 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 650 15 0 8 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
118713590 121152 0 None 16 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 5 3.7 O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331259 121152 0 None 16 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 381 7 0 5 3.7 O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
162675477 190221 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 464 6 0 4 5.4 COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4798874 190221 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 464 6 0 4 5.4 COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
44424653 148868 0 None -4 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 456 8 0 10 1.1 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
CHEMBL388133 148868 0 None -4 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 456 8 0 10 1.1 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
46204730 131347 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 nan
CHEMBL3640576 131347 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 nan
46204730 131347 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 nan
CHEMBL3640576 131347 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 273 3 1 2 3.7 Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 nan
130442572 178687 0 None -87 24 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 395 3 0 5 6.0 FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4469848 178687 0 None -87 24 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 395 3 0 5 6.0 FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
19958507 106197 0 None -81 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 320 4 1 3 3.4 CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
CHEMBL282829 106197 0 None -81 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 320 4 1 3 3.4 CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
46233353 209124 3 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 259 4 0 2 3.1 CN(C)CCSc1ccccc1Br 10.1016/j.bmc.2010.01.035
CHEMBL610515 209124 3 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 259 4 0 2 3.1 CN(C)CCSc1ccccc1Br 10.1016/j.bmc.2010.01.035
136118617 83024 0 None -4 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 332 1 2 2 2.3 C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C 10.1016/j.bmc.2013.09.011
CHEMBL2058416 83024 0 None -4 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 332 1 2 2 2.3 C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C 10.1016/j.bmc.2013.09.011
10267394 107165 3 None -181 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 310 3 1 3 3.0 Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
CHEMBL28997 107165 3 None -181 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 310 3 1 3 3.0 Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
57399432 77240 0 None -14 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 399 6 0 4 5.5 Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
CHEMBL1946254 77240 0 None -14 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 399 6 0 4 5.5 Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
90469187 192787 0 None -1380 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 406 3 1 6 3.1 Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1 10.1021/acs.jmedchem.1c00224
CHEMBL4870374 192787 0 None -1380 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 406 3 1 6 3.1 Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1 10.1021/acs.jmedchem.1c00224
71462065 87939 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 424 7 1 3 4.7 O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2158030 87939 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 424 7 1 3 4.7 O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
145976698 170724 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4207656 170724 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
90654695 116858 0 None 1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 422 6 1 5 2.1 COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235732 116858 0 None 1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 422 6 1 5 2.1 COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
11048252 210961 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 429 7 2 3 4.3 NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
CHEMBL70764 210961 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 429 7 2 3 4.3 NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
168296329 199217 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 359 3 2 4 2.7 O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1 10.1016/j.ejmech.2022.114218
CHEMBL5208347 199217 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 359 3 2 4 2.7 O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1 10.1016/j.ejmech.2022.114218
164628177 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4875079 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL5029038 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL5079536 221401 0 None -60 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None Cc1c(S(=O)(=O)N[C@H]2C[C@H](C)N(CCCc3noc4cc(F)ccc34)C2)sc2ccc(Cl)cc12 10.1021/acs.jmedchem.1c00497
56850658 78295 0 None -19 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 1.6 O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926745 78295 0 None -19 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 1.6 O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962804 78295 0 None -19 2 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 1.6 O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
53377324 73421 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 481 6 0 6 4.6 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1812290 73421 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 481 6 0 6 4.6 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1852853 73421 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 481 6 0 6 4.6 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.ejmech.2011.04.060
135458672 124711 10 None -1 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 387 3 2 3 4.1 Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403337 124711 10 None -1 4 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 387 3 2 3 4.1 Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1 10.1016/j.bmcl.2015.03.049
45113400 21003 2 None -19 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay
ChEMBL 359 3 2 3 3.1 CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1 10.1016/j.ejmech.2009.10.035
CHEMBL1099284 21003 2 None -19 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay
ChEMBL 359 3 2 3 3.1 CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1 10.1016/j.ejmech.2009.10.035
CHEMBL1199172 21003 2 None -19 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay
ChEMBL 359 3 2 3 3.1 CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1 10.1016/j.ejmech.2009.10.035
138691329 177502 0 None 100 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 245 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(Cl)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4452121 177502 0 None 100 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 245 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(Cl)cc12 10.1016/j.ejmech.2019.03.017
127040444 143559 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 402 8 1 4 3.6 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1039/C5MD00166H
CHEMBL3741279 143559 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 402 8 1 4 3.6 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1039/C5MD00166H
156018601 184673 0 None 9 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 414 6 1 5 3.4 C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4644833 184673 0 None 9 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 414 6 1 5 3.4 C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
118051679 176928 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 480 9 1 7 2.8 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4444280 176928 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 480 9 1 7 2.8 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
59395105 113117 1 None -4 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 252 1 3 1 1.7 NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12 10.1016/j.bmc.2013.10.010
CHEMBL3092755 113117 1 None -4 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 252 1 3 1 1.7 NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12 10.1016/j.bmc.2013.10.010
CHEMBL3139187 113117 1 None -4 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
ChEMBL 252 1 3 1 1.7 NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12 10.1016/j.bmc.2013.10.010
25108474 199979 0 None -38 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 8 0 4 4.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL523381 199979 0 None -38 3 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 423 8 0 4 4.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
44437330 158968 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 706 19 0 8 7.5 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396844 158968 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 706 19 0 8 7.5 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
71602692 96464 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376461 96464 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2013.02.038
162651292 187001 0 None -33 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 10.1016/j.ejmech.2020.112149
CHEMBL4749824 187001 0 None -33 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 10.1016/j.ejmech.2020.112149
162666019 189079 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 532 9 0 6 6.4 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4784089 189079 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 532 9 0 6 6.4 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1 10.1016/j.ejmech.2020.112395
164628177 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL4875079 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL5029038 195390 0 None -4 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 366 7 1 5 2.8 CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
155551114 183449 0 None -6 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 431 8 0 3 5.3 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4541606 183449 0 None -6 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 431 8 0 3 5.3 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4598210 183449 0 None -6 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 431 8 0 3 5.3 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2019.06.028
13091356 120315 0 None -102 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 389 6 1 3 4.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
CHEMBL3321789 120315 0 None -102 8 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 389 6 1 3 4.8 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
155529153 178180 0 None -38 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 378 4 1 6 0.3 CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4462404 178180 0 None -38 5 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 378 4 1 6 0.3 CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
135367855 171161 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4213067 171161 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
60165541 82121 0 None -9 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 364 6 0 4 5.1 O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037518 82121 0 None -9 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 364 6 0 4 5.1 O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
24768523 150458 0 None -4 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 498 10 2 5 3.9 CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL390015 150458 0 None -4 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 498 10 2 5 3.9 CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
71727069 109182 0 None -3 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 4 0 5 4.3 COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1 10.1016/j.bmcl.2013.05.062
CHEMBL2401935 109182 0 None -3 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 4 0 5 4.3 COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1 10.1016/j.bmcl.2013.05.062
CHEMBL3039672 109182 0 None -3 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 4 0 5 4.3 COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1 10.1016/j.bmcl.2013.05.062
135367855 171161 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4213067 171161 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccccc1-c1noc2c1CCNCC2 10.1021/acs.jmedchem.8b00642
71462155 88143 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 6 1 3 4.9 Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159316 88143 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 408 6 1 3 4.9 Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1 10.1016/j.ejmech.2012.07.043
118464427 145112 0 None -15 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 328 3 4 6 1.8 CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
CHEMBL3771331 145112 0 None -15 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 328 3 4 6 1.8 CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
168282819 197989 0 None 2 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 419 10 4 8 3.1 COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5189520 197989 0 None 2 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 419 10 4 8 3.1 COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
11142729 126511 0 None 3 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 352 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL347629 126511 0 None 3 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 352 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O 10.1021/jm020994z
1613 9127 53 None -14 44 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1021/jm030030n
205 9127 53 None -14 44 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1021/jm030030n
3964 9127 53 None -14 44 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1021/jm030030n
CHEMBL831 9127 53 None -14 44 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1021/jm030030n
DB00408 9127 53 None -14 44 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1021/jm030030n
24944943 109287 0 None -17 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 381 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12 10.1021/jm400766k
CHEMBL2431038 109287 0 None -17 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 381 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12 10.1021/jm400766k
CHEMBL3040400 109287 0 None -17 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
ChEMBL 381 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12 10.1021/jm400766k
122181346 128666 0 None 2 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 494 7 1 4 4.9 O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590098 128666 0 None 2 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 494 7 1 4 4.9 O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
145977256 170328 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 391 4 1 3 3.5 O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4202947 170328 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 391 4 1 3 3.5 O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
118731350 124965 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 490 10 1 4 4.3 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409034 124965 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 490 10 1 4 4.3 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
71602692 96464 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376461 96464 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2013.02.038
23151712 127314 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 266 1 3 2 1.1 NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310120 127314 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 266 1 3 2 1.1 NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545471 127314 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 266 1 3 2 1.1 NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2 10.1016/j.bmc.2014.05.027
118736369 125719 0 None -4 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 541 8 1 10 3.1 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423333 125719 0 None -4 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 541 8 1 10 3.1 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
16754 92349 50 None 2 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 355 4 0 5 3.5 COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL228082 92349 50 None 2 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 355 4 0 5 3.5 COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
44437335 158436 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 722 16 0 11 5.0 COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL396396 158436 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 722 16 0 11 5.0 COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
10593348 104070 0 None 4 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
CHEMBL26907 104070 0 None 4 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 341 1 1 2 5.1 Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 10.1021/jm0108505
11375902 173012 0 None -1 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
CHEMBL426723 173012 0 None -1 2 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm049702f
11121721 126530 0 None -6 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 352 8 0 4 3.9 COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1 10.1021/jm020994z
CHEMBL347837 126530 0 None -6 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 352 8 0 4 3.9 COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1 10.1021/jm020994z
11058564 108850 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 404 6 2 3 4.4 O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3 10.1021/jm0104264
CHEMBL302093 108850 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 404 6 2 3 4.4 O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3 10.1021/jm0104264
134146195 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3941795 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3991399 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL5088232 221925 0 None -28 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
72549988 120851 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 11 1 4 5.4 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326978 120851 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 11 1 4 5.4 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
72547876 120860 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2014.07.026
CHEMBL3326987 120860 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 487 11 1 5 5.0 COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2014.07.026
155540755 179723 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 6 3.8 COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1 10.1016/j.ejmech.2019.111690
CHEMBL4516999 179723 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 6 3.8 COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1 10.1016/j.ejmech.2019.111690
46205701 131373 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1 nan
CHEMBL3640601 131373 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 0 1 4.1 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1 nan
46205701 131373 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1 nan
CHEMBL3640601 131373 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 0 1 4.1 Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1 nan
71602583 96467 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 358 5 0 3 4.7 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376469 96467 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 358 5 0 3 4.7 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
155522563 183435 0 None -9 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4453687 183435 0 None -9 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4598088 183435 0 None -9 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 483 8 0 4 5.4 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
162674779 190558 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4798599 190558 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4804025 190558 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 10 1 4 5.1 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
13069611 127389 0 None -363 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 426 7 0 9 1.0 COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3360995 127389 0 None -363 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 426 7 0 9 1.0 COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
CHEMBL3546110 127389 0 None -363 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 426 7 0 9 1.0 COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1 10.1016/j.bmc.2014.11.008
90656684 117753 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 375 6 1 4 4.2 CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262409 117753 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 375 6 1 4 4.2 CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
71602583 96467 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 358 5 0 3 4.7 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376469 96467 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 358 5 0 3 4.7 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2013.02.038
137646045 164568 0 None -436 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 404 4 0 5 4.3 CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1 10.1021/acsmedchemlett.6b00482
CHEMBL4083059 164568 0 None -436 5 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 404 4 0 5 4.3 CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1 10.1021/acsmedchemlett.6b00482
242 7258 124 None -15 51 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2018.01.002
34 7258 124 None -15 51 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2018.01.002
60795 7258 124 None -15 51 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2018.01.002
CHEMBL1112 7258 124 None -15 51 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2018.01.002
DB01238 7258 124 None -15 51 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2018.01.002
134146185 155616 0 None 18 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 512 10 1 5 4.6 O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3941102 155616 0 None 18 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 512 10 1 5 4.6 O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
138691362 177730 0 None 48 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 225 2 1 2 3.4 CCn1cncc1-c1c[nH]c2ccc(C)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4455588 177730 0 None 48 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 225 2 1 2 3.4 CCn1cncc1-c1c[nH]c2ccc(C)cc12 10.1016/j.ejmech.2019.03.017
127038034 143447 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 416 9 1 4 3.8 CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1039/C5MD00166H
CHEMBL3740209 143447 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 416 9 1 4 3.8 CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1 10.1039/C5MD00166H
134146195 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3941795 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
CHEMBL3991399 161370 0 None -3 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 362 5 0 3 5.8 Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 10.1016/j.bmc.2016.09.019
24854106 167840 1 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm070279v
CHEMBL411663 167840 1 None -2 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm070279v
162668734 189383 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 470 8 1 5 4.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4788259 189383 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 470 8 1 5 4.7 COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1 10.1016/j.ejmech.2020.112395
134133968 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3899099 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3990801 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
132547275 149021 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 9 0 5 5.2 Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1 10.1016/j.bmc.2016.12.039
CHEMBL3884714 149021 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 9 0 5 5.2 Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1 10.1016/j.bmc.2016.12.039
44424664 92490 0 None -4 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 411 7 0 8 1.7 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
CHEMBL228881 92490 0 None -4 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 411 7 0 8 1.7 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
73349361 99323 0 None -5 7 Human 5.4 pKi = 5.4 Binding
Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 279 4 0 1 3.3 CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41 10.1016/j.bmc.2013.07.045
CHEMBL2432058 99323 0 None -5 7 Human 5.4 pKi = 5.4 Binding
Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 279 4 0 1 3.3 CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41 10.1016/j.bmc.2013.07.045
76332581 113190 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121426 113190 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3139510 113190 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 417 4 0 3 6.1 c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
53325850 63785 0 None - 1 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl 10.1016/j.bmcl.2010.11.078
CHEMBL1644271 63785 0 None - 1 Rat 5.4 pKi = 5.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl 10.1016/j.bmcl.2010.11.078
5074 10105 80 None -69 30 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
97 10105 80 None -69 30 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
CHEMBL267777 10105 80 None -69 30 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
DB12693 10105 80 None -69 30 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.1021/jm030030n
145983059 172424 0 None -6 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 492 6 0 6 4.4 O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4243932 172424 0 None -6 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 492 6 0 6 4.4 O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 10.1016/j.ejmech.2018.01.002
90654846 119473 0 None 4 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233672 119473 0 None 4 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304317 119473 0 None 4 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 466 9 0 4 4.4 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
134133968 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3899099 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3990801 161302 0 None -1 9 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 356 5 0 3 5.3 Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.09.019
164621388 192515 0 None -7 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 0 3 3.7 Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 10.1016/j.ejmech.2021.113243
CHEMBL4866058 192515 0 None -7 7 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 0 3 3.7 Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 10.1016/j.ejmech.2021.113243
53323115 63793 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 306 3 1 2 4.0 Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644279 63793 0 None - 1 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 306 3 1 2 4.0 Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
44439390 154582 0 None 33 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 322 4 2 3 3.6 COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL393275 154582 0 None 33 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 322 4 2 3 3.6 COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1 10.1016/j.bmcl.2007.01.093
132547278 149026 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 446 10 0 6 4.3 CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884778 149026 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 446 10 0 6 4.3 CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1 10.1016/j.bmc.2016.12.039
76284455 111788 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 491 11 1 5 4.3 COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113600 111788 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 491 11 1 5 4.3 COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2014.01.016
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/acsmedchemlett.6b00482
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/acsmedchemlett.6b00482
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/acsmedchemlett.6b00482
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/acsmedchemlett.6b00482
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/acsmedchemlett.6b00482
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.111857
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.111857
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.111857
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.111857
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.111857
118713685 121167 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 393 9 0 5 4.4 O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331388 121167 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 393 9 0 5 4.4 O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
6603866 104204 17 None -39 9 Rat 7.3 pKi = 7.3 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm030826m
CHEMBL26998 104204 17 None -39 9 Rat 7.3 pKi = 7.3 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm030826m
CHEMBL541268 104204 17 None -39 9 Rat 7.3 pKi = 7.3 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm030826m
11058267 211186 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 391 6 1 5 3.0 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3 10.1021/jm0104264
CHEMBL72008 211186 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 391 6 1 5 3.0 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3 10.1021/jm0104264
71602740 96392 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2375370 96392 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2013.02.038
164621388 192515 0 None -7 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 0 3 3.7 Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 10.1016/j.ejmech.2021.113243
CHEMBL4866058 192515 0 None -7 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 0 3 3.7 Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 10.1016/j.ejmech.2021.113243
44324572 213549 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 319 2 2 3 4.1 Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00925-3
CHEMBL90150 213549 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes
ChEMBL 319 2 2 3 4.1 Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00925-3
162670644 189758 0 None 17 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 417 9 0 5 5.2 COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4793310 189758 0 None 17 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 417 9 0 5 5.2 COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
156017025 184505 0 None 3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 351 2 0 1 6.1 CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1 10.1016/j.bmc.2019.115262
CHEMBL4642336 184505 0 None 3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 351 2 0 1 6.1 CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1 10.1016/j.bmc.2019.115262
11221282 63788 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 333 4 1 4 3.8 O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644274 63788 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 333 4 1 4 3.8 O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
162664163 190502 3 None -56 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4782285 190502 3 None -56 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803403 190502 3 None -56 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 409 9 1 4 4.8 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
46204736 131353 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 5 1 3 3.4 CCOc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
CHEMBL3640581 131353 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 5 1 3 3.4 CCOc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
46204736 131353 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 5 1 3 3.4 CCOc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
CHEMBL3640581 131353 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 5 1 3 3.4 CCOc1ccc(-c2ccccc2C)cc1OC1CNC1 nan
156013736 184042 0 None -1 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 404 6 1 4 4.2 C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4636165 184042 0 None -1 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 404 6 1 4 4.2 C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
44408995 82209 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 381 8 0 5 3.3 CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1 10.1016/j.bmcl.2005.11.067
CHEMBL204174 82209 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 381 8 0 5 3.3 CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1 10.1016/j.bmcl.2005.11.067
90654858 119477 0 None 4 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 550 9 0 4 6.2 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233678 119477 0 None 4 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 550 9 0 4 6.2 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304355 119477 0 None 4 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 550 9 0 4 6.2 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.01.065
155539600 179638 0 None -239 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 364 4 1 7 2.7 CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4515075 179638 0 None -239 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 364 4 1 7 2.7 CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
155524228 177654 0 None -141 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 516 8 2 4 5.3 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
CHEMBL4454176 177654 0 None -141 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 516 8 2 4 5.3 COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2019.111736
11761105 60415 0 None -13 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 396 10 0 5 4.3 COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
CHEMBL160286 60415 0 None -13 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 396 10 0 5 4.3 COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
71454998 88192 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 9 1 4 4.5 CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159460 88192 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 9 1 4 4.5 CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2012.07.043
71574206 93043 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 512 7 1 5 4.7 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.ejmech.2012.11.042
CHEMBL2312641 93043 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 512 7 1 5 4.7 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.ejmech.2012.11.042
90654852 119413 0 None 6 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233675 119413 0 None 6 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3302762 119413 0 None 6 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 484 9 0 4 4.5 CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1 10.1016/j.ejmech.2014.01.065
155561901 182535 0 None 5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 259 3 1 3 3.2 CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4583507 182535 0 None 5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 259 3 1 3 3.2 CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12 10.1016/j.ejmech.2019.03.017
71602740 96392 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2375370 96392 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmc.2013.02.038
23661734 97661 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 425 6 0 4 3.8 CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1 10.1016/j.bmc.2007.07.029
CHEMBL239259 97661 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells
ChEMBL 425 6 0 4 3.8 CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1 10.1016/j.bmc.2007.07.029
44439395 98585 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 296 2 3 2 3.4 Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
CHEMBL241280 98585 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 296 2 3 2 3.4 Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21 10.1016/j.bmcl.2007.01.093
72550641 120865 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 477 9 1 4 5.2 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326992 120865 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 477 9 1 4 5.2 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
117209857 191917 1 None -1 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4856702 191917 1 None -1 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL5089348 221982 0 None -23 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.1c00497
135367405 170975 0 None 2 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None 2 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
118713591 121154 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 0 5 4.3 O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331260 121154 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 401 6 0 5 4.3 O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.08.023
9862256 213899 0 None -301 9 Human 6.3 pKi = 6.3 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL92139 213899 0 None -301 9 Human 6.3 pKi = 6.3 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
11122723 57780 0 None -1 2 Rat 6.3 pKi = 6.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 423 9 1 7 4.1 COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1 10.1021/jm020994z
CHEMBL157840 57780 0 None -1 2 Rat 6.3 pKi = 6.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 423 9 1 7 4.1 COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1 10.1021/jm020994z
163409061 198968 3 None -13 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 456 8 1 6 3.2 O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
CHEMBL5204274 198968 3 None -13 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 456 8 1 6 3.2 O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2022.114319
155536809 178977 0 None 3 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 412 5 0 4 3.2 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4473710 178977 0 None 3 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 412 5 0 4 3.2 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
128 6937 11 None -295 7 Human 6.3 pKi = 6.3 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cccc2O)CCC 10.1021/acs.jmedchem.7b01898
172267 6937 11 None -295 7 Human 6.3 pKi = 6.3 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cccc2O)CCC 10.1021/acs.jmedchem.7b01898
CHEMBL273273 6937 11 None -295 7 Human 6.3 pKi = 6.3 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cccc2O)CCC 10.1021/acs.jmedchem.7b01898
1220 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
31 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
7 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
CHEMBL56 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030030n
71062646 156322 0 None -776 13 Mouse 6.3 pKi = 6.3 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 338 6 0 4 2.8 c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 nan
CHEMBL3946661 156322 0 None -776 13 Mouse 6.3 pKi = 6.3 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 338 6 0 4 2.8 c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 nan
122181337 128657 0 None -21 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 462 7 1 5 3.4 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590089 128657 0 None -21 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 462 7 1 5 3.4 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1 10.1016/j.bmc.2015.04.026
127028471 144959 0 None 8 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 460 6 2 5 2.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3769606 144959 0 None 8 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 460 6 2 5 2.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O 10.1016/j.ejmech.2016.02.024
117209857 191917 1 None -1 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4856702 191917 1 None -1 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 10.1021/acs.jmedchem.1c01093
57325521 78345 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1949977 78345 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
CHEMBL1963103 78345 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 498 6 0 5 4.5 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmc.2011.12.039
24854106 167840 1 None -2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm200547z
CHEMBL411663 167840 1 None -2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm200547z
135367405 170975 0 None 2 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4210782 170975 0 None 2 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
42625445 193557 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 399 6 0 3 4.3 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
CHEMBL489028 193557 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 399 6 0 3 4.3 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
162662892 188693 0 None 20 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 468 9 0 4 6.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4779459 188693 0 None 20 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 468 9 0 4 6.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1 10.1016/j.ejmech.2020.112395
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.03.017
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.03.017
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.03.017
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.03.017
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.03.017
72548117 120863 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326990 120863 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1 10.1016/j.bmc.2014.07.026
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
CHEMBL5093250 222199 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(F)c1 10.1021/acs.jmedchem.1c00497
46205368 131360 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 291 3 1 2 3.8 Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F nan
CHEMBL3640588 131360 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 291 3 1 2 3.8 Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F nan
46205368 131360 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 291 3 1 2 3.8 Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F nan
CHEMBL3640588 131360 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 291 3 1 2 3.8 Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F nan
162666903 190513 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 369 7 2 5 2.9 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4787550 190513 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 369 7 2 5 2.9 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803553 190513 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 369 7 2 5 2.9 COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1 10.1016/j.ejmech.2020.112437
2133793 28589 13 None 1 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 476 5 2 5 6.2 O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL1319488 28589 13 None 1 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 476 5 2 5 6.2 O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1 10.1016/j.bmcl.2015.03.049
3649661 144997 7 None -64 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 329 3 3 7 2.2 CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
CHEMBL3770106 144997 7 None -64 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 329 3 3 7 2.2 CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
76518514 120314 0 None -50 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 387 6 1 2 5.3 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
CHEMBL3321788 120314 0 None -50 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 387 6 1 2 5.3 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
118736395 125727 0 None -234 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 493 7 1 11 0.7 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423377 125727 0 None -234 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 493 7 1 11 0.7 Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
168287240 198516 0 None 1 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 457 9 4 7 4.4 Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5197266 198516 0 None 1 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 457 9 4 7 4.4 Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
155534301 178714 0 None -11 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 415 8 0 5 4.0 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4470304 178714 0 None -11 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 415 8 0 5 4.0 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1 10.1016/j.bmcl.2019.06.029
90654678 116876 0 None -6 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 450 8 2 5 2.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235750 116876 0 None -6 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 450 8 2 5 2.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2014.03.005
44424652 92699 0 None 2 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 426 7 0 9 1.0 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229940 92699 0 None 2 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 426 7 0 9 1.0 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
90654699 116862 0 None -12 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 406 8 1 4 2.5 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235736 116862 0 None -12 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 406 8 1 4 2.5 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.03.005
52952309 69364 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 427 7 1 6 4.8 O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12 10.1021/jm2000773
CHEMBL1782807 69364 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 427 7 1 6 4.8 O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12 10.1021/jm2000773
13069602 127390 0 None -478 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 430 6 0 8 1.7 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360996 127390 0 None -478 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 430 6 0 8 1.7 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546112 127390 0 None -478 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 430 6 0 8 1.7 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
76310811 113054 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 5 0 3 5.5 CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121417 113054 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 5 0 3 5.5 CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139021 113054 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 395 5 0 3 5.5 CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
6603866 104204 17 None -95 9 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
CHEMBL26998 104204 17 None -95 9 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
CHEMBL541268 104204 17 None -95 9 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1016/j.bmc.2019.115262
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm049632c
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm049632c
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm049632c
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm049632c
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm049632c
23369455 188254 2 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 350 6 1 4 2.9 O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL476462 188254 2 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 350 6 1 4 2.9 O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
135398737 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
38 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
722 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
CHEMBL42 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
DB00363 7745 93 None -13 90 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.ejmech.2019.06.001
11248332 91085 0 None -2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL221513 91085 0 None -2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
127036953 144293 0 None -4 22 Human 7.3 pKi = 7.3 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3754166 144293 0 None -4 22 Human 7.3 pKi = 7.3 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
117209971 193264 1 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4877051 193264 1 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL5076846 221243 0 None -75 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(F)cc3s2)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
9926401 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819556 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819732 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
53377239 73164 0 None -15 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1 10.1016/j.ejmech.2011.04.060
CHEMBL1851772 73164 0 None -15 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1 10.1016/j.ejmech.2011.04.060
CHEMBL3217162 73164 0 None -15 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 443 7 0 7 3.6 COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1 10.1016/j.ejmech.2011.04.060
155514217 176611 0 None -17 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 461 8 0 5 3.9 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4439795 176611 0 None -17 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 461 8 0 5 3.9 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
155551685 181911 0 None -4 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 495 8 0 5 4.5 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4569757 181911 0 None -4 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 495 8 0 5 4.5 O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmcl.2021.128028
164618482 192694 0 None -13 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1 10.1016/j.ejmech.2020.112529
CHEMBL4868911 192694 0 None -13 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1 10.1016/j.ejmech.2020.112529
155552799 183084 0 None -91 5 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4545270 183084 0 None -91 5 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595236 183084 0 None -91 5 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.2 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
9878197 202957 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 250 4 4 3 1.0 CCOc1ccccc1CNC(=N)NC(=O)NC 10.1016/j.bmcl.2009.06.038
CHEMBL561346 202957 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 250 4 4 3 1.0 CCOc1ccccc1CNC(=N)NC(=O)NC 10.1016/j.bmcl.2009.06.038
127037921 143809 0 None 4 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 9 0 6 3.7 Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1 10.1016/j.bmc.2015.11.041
CHEMBL3746493 143809 0 None 4 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 9 0 6 3.7 Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1 10.1016/j.bmc.2015.11.041
155512944 176498 0 None 11 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 249 1 1 2 3.4 Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4438349 176498 0 None 11 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 249 1 1 2 3.4 Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12 10.1016/j.ejmech.2019.03.017
127038035 143495 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 436 8 1 4 4.2 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1039/C5MD00166H
CHEMBL3740691 143495 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 436 8 1 4 4.2 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1 10.1039/C5MD00166H
117209971 193264 1 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4877051 193264 1 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 258 3 2 4 1.5 COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
9926401 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819556 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3819732 147653 0 None 2 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 301 5 0 2 4.4 Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
24768517 99603 0 None 2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 10 1 3 5.5 CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243742 99603 0 None 2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 10 1 3 5.5 CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
57397588 78254 0 None -24 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 375 7 1 5 2.4 O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926747 78254 0 None -24 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 375 7 1 5 2.4 O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962460 78254 0 None -24 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 375 7 1 5 2.4 O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
90654691 116854 0 None -21 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 432 10 1 5 3.0 CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235728 116854 0 None -21 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 432 10 1 5 3.0 CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
162673808 190553 0 None -23 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4795248 190553 0 None -23 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803963 190553 0 None -23 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
11421045 143719 0 None 1 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
CHEMBL374298 143719 0 None 1 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 447 9 1 4 4.8 CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
134133633 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3899822 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3991400 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
44582678 188353 0 None -3 10 Human 6.3 pKi = 6.3 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 401 9 1 4 4.3 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL476839 188353 0 None -3 10 Human 6.3 pKi = 6.3 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 401 9 1 4 4.3 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 10.1016/j.bmc.2009.03.021
44393088 71787 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL182322 71787 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 386 8 3 7 3.4 CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
44393170 72009 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 336 7 2 4 4.4 C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182680 72009 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 336 7 2 4 4.4 C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
44393171 72163 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182943 72163 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 8 2 5 4.3 C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1 10.1016/j.bmcl.2004.06.007
10785714 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030030n
CHEMBL13052 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030030n
127042184 143760 0 None 6 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 468 8 0 4 4.7 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmc.2015.11.041
CHEMBL3745815 143760 0 None 6 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 468 8 0 4 4.7 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmc.2015.11.041
2865 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1016/j.ejmech.2018.01.002
59 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1016/j.ejmech.2018.01.002
60854 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1016/j.ejmech.2018.01.002
CHEMBL708 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1016/j.ejmech.2018.01.002
DB00246 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1016/j.ejmech.2018.01.002
71458625 88150 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 432 8 1 6 3.6 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159322 88150 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 432 8 1 6 3.6 CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
71458626 88151 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159323 88151 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 440 8 1 4 3.9 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
118731356 124970 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409039 124970 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 502 8 0 4 4.6 O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
138691364 178686 2 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 254 3 2 3 2.2 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4469847 178686 2 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 254 3 2 3 2.2 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1016/j.ejmech.2019.03.017
138691364 178686 2 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 254 3 2 3 2.2 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1039/C8MD00313K
CHEMBL4469847 178686 2 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 254 3 2 3 2.2 CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1039/C8MD00313K
145982165 173383 0 None 51 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 488 7 2 6 2.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1 10.1039/C8MD00168E
CHEMBL4280511 173383 0 None 51 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 488 7 2 6 2.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1 10.1039/C8MD00168E
137651887 164078 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 443 7 2 3 4.6 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4077040 164078 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 443 7 2 3 4.6 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
9845006 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/j.bmc.2019.06.028
CHEMBL12702 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/j.bmc.2019.06.028
11646336 72770 1 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm200547z
CHEMBL1836785 72770 1 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 367 6 1 3 3.9 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm200547z
44372581 126597 0 None - 1 Human 8.3 pKi = 8.3 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 420 6 1 2 5.8 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
CHEMBL348410 126597 0 None - 1 Human 8.3 pKi = 8.3 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 420 6 1 2 5.8 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
9845006 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12702 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1016/s0960-894x(00)00166-9
10785714 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
CHEMBL13052 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1016/s0960-894x(00)00166-9
9845006 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm030841r
CHEMBL12702 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm030841r
10785714 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
CHEMBL13052 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm030841r
162659494 188133 0 None -15 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4763085 188133 0 None -15 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 10.1016/j.ejmech.2020.112149
162674158 189782 0 None -12 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 10.1016/j.ejmech.2020.112149
CHEMBL4793608 189782 0 None -12 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 441 7 1 6 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 10.1016/j.ejmech.2020.112149
107 6929 121 None -3 31 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1016/j.ejmech.2019.111705
1833 6929 121 None -3 31 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1016/j.ejmech.2019.111705
CHEMBL8165 6929 121 None -3 31 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 10.1016/j.ejmech.2019.111705
2865 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm070516u
59 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm070516u
60854 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm070516u
CHEMBL708 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm070516u
DB00246 10915 73 None -12 53 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm070516u
11536843 121901 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
CHEMBL3343673 121901 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
ChEMBL 307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 10.1016/j.bmc.2014.09.005
54758293 72771 0 None 7 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.3 CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL1836786 72771 0 None 7 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 445 7 1 3 5.3 CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
56944186 118867 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 504 8 1 7 4.6 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3289984 118867 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 504 8 1 7 4.6 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
56944190 118877 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 499 8 1 5 5.2 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289994 118877 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 499 8 1 5 5.2 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
25107578 199835 0 None 4 3 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 10 1 4 4.2 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
CHEMBL522343 199835 0 None 4 3 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 10 1 4 4.2 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 10.1021/jm800615e
24854370 163849 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL407412 163849 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
9845006 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL12702 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
9845006 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm980519u
CHEMBL12702 25011 0 None - 1 Human 8.3 pKi = 8.3 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 419 7 1 4 4.2 COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm980519u
118713680 121162 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 411 8 0 6 4.1 COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331383 121162 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 411 8 0 6 4.1 COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
92042876 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
10402615 209296 0 None -20 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 301 2 0 1 4.9 CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2019.115262
CHEMBL611472 209296 0 None -20 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 301 2 0 1 4.9 CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 10.1016/j.bmc.2019.115262
92042876 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3961059 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
10785714 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
CHEMBL13052 27000 0 None - 1 Human 8.3 pKi = 8.3 Binding
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
ChEMBL 375 5 1 3 3.8 O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3 10.1021/jm980519u
92042876 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL3961059 158115 0 None 2 10 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL 261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
71457985 85312 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2 10.1016/j.bmcl.2004.11.013
CHEMBL2112053 85312 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2 10.1016/j.bmcl.2004.11.013
11153905 72380 0 None -2 2 Rat 8.3 pKi = 8.3 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2 10.1021/jm0498102
CHEMBL183329 72380 0 None -2 2 Rat 8.3 pKi = 8.3 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 313 4 0 4 3.2 COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2 10.1021/jm0498102
156013466 184288 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
CHEMBL4639638 184288 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
156013520 184290 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 325 6 0 1 5.5 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
CHEMBL4639661 184290 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 325 6 0 1 5.5 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
66801140 118439 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 482 8 1 6 4.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3286432 118439 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 482 8 1 6 4.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
24854039 102542 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 394 7 1 2 5.5 CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL258537 102542 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 394 7 1 2 5.5 CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
11603891 103690 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL265927 103690 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21 10.1021/jm070279v
11617668 71470 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2005.05.059
CHEMBL181874 71470 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2005.05.059
11603891 103690 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL265927 103690 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 407 8 1 4 4.3 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
11617668 71470 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2007.03.054
CHEMBL181874 71470 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 372 5 0 5 3.7 COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1 10.1016/j.bmcl.2007.03.054
46205370 131362 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 1 2 3.7 COc1ccc(-c2ccccc2C)cc1C1CCNC1 nan
CHEMBL3640590 131362 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 1 2 3.7 COc1ccc(-c2ccccc2C)cc1C1CCNC1 nan
46205370 131362 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 1 2 3.7 COc1ccc(-c2ccccc2C)cc1C1CCNC1 nan
CHEMBL3640590 131362 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 1 2 3.7 COc1ccc(-c2ccccc2C)cc1C1CCNC1 nan
162650362 186792 0 None -27 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4747225 186792 0 None -27 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 10.1016/j.ejmech.2020.112149
135398737 7745 93 None -13 90 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
38 7745 93 None -13 90 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
722 7745 93 None -13 90 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
CHEMBL42 7745 93 None -13 90 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
DB00363 7745 93 None -13 90 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
10706553 104472 0 None 5 5 Rat 8.3 pKi = 8.3 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 261 0 0 1 3.9 C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL27132 104472 0 None 5 5 Rat 8.3 pKi = 8.3 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 261 0 0 1 3.9 C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
101747513 180101 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant
ChEMBL 277 4 0 5 3.2 CN(C)CCSc1nc2ccsc2n2cccc12 10.1016/j.ejmech.2019.111690
CHEMBL4526441 180101 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant
ChEMBL 277 4 0 5 3.2 CN(C)CCSc1nc2ccsc2n2cccc12 10.1016/j.ejmech.2019.111690
154926523 197070 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant
ChEMBL 425 9 1 4 4.2 CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21 10.1021/acs.jmedchem.2c00633
CHEMBL5175774 197070 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant
ChEMBL 425 9 1 4 4.2 CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21 10.1021/acs.jmedchem.2c00633
11976 7707 59 None -5 24 Rat 8.3 pKi = 8.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1021/jm030030n
667467 7707 59 None -5 24 Rat 8.3 pKi = 8.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1021/jm030030n
CHEMBL908 7707 59 None -5 24 Rat 8.3 pKi = 8.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1021/jm030030n
DB01239 7707 59 None -5 24 Rat 8.3 pKi = 8.3 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1021/jm030030n
23661594 97400 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 664 16 0 8 6.3 COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL238808 97400 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 664 16 0 8 6.3 COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
25107718 194317 0 None 18 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 535 12 1 6 4.7 CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1021/jm800615e
CHEMBL494458 194317 0 None 18 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 535 12 1 6 4.7 CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 10.1021/jm800615e
9887186 211076 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 399 5 2 2 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3 10.1021/jm0104264
CHEMBL71383 211076 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 399 5 2 2 4.9 O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3 10.1021/jm0104264
10948963 55789 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1 10.1021/jm020994z
CHEMBL156089 55789 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 1 5 4.0 COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1 10.1021/jm020994z
135398737 7745 93 None -13 90 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
38 7745 93 None -13 90 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
722 7745 93 None -13 90 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
CHEMBL42 7745 93 None -13 90 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
DB00363 7745 93 None -13 90 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2013.12.024
156011291 184155 0 None -9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 341 6 0 1 6.0 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
CHEMBL4637900 184155 0 None -9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 341 6 0 1 6.0 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 10.1016/j.bmc.2019.115262
118713679 121161 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 395 8 0 6 3.6 COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331382 121161 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 395 8 0 6 3.6 COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
56944189 118870 0 None 2 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 454 8 1 8 2.4 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
CHEMBL3289987 118870 0 None 2 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 454 8 1 8 2.4 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
24854272 102974 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21 10.1021/jm070279v
CHEMBL260761 102974 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21 10.1021/jm070279v
46204081 131328 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 5 1 4 2.7 COc1ccc(-c2ccccc2OC)cc1OC1CNC1 nan
CHEMBL3640558 131328 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 285 5 1 4 2.7 COc1ccc(-c2ccccc2OC)cc1OC1CNC1 nan
46204081 131328 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 5 1 4 2.7 COc1ccc(-c2ccccc2OC)cc1OC1CNC1 nan
CHEMBL3640558 131328 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 285 5 1 4 2.7 COc1ccc(-c2ccccc2OC)cc1OC1CNC1 nan
90654704 116867 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 413 8 1 6 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235741 116867 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 413 8 1 6 2.0 NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2014.03.005
127026141 144442 0 None 19 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 466 8 1 6 3.4 Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1 10.1016/j.ejmech.2015.11.040
CHEMBL3758488 144442 0 None 19 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 466 8 1 6 3.4 Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1 10.1016/j.ejmech.2015.11.040
155562997 182016 0 None -3 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2019.111736
CHEMBL4571862 182016 0 None -3 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 486 7 2 3 5.3 O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2019.111736
145946840 174365 0 None 3 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 7 2 6 2.0 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4176588 174365 0 None 3 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 7 2 6 2.0 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4300745 174365 0 None 3 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 7 2 6 2.0 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
57394663 78330 0 None 2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949973 78330 0 None 2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963031 78330 0 None 2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 457 8 1 4 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.12.039
118706294 127313 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 311 3 3 3 1.3 COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
CHEMBL3310118 127313 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 311 3 3 3 1.3 COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
CHEMBL3545470 127313 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 311 3 3 3 1.3 COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O 10.1016/j.bmc.2014.05.027
122178708 128152 0 None 1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 423 5 0 5 5.2 COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581253 128152 0 None 1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 423 5 0 5 5.2 COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
53248365 68860 0 None -52 7 Human 7.3 pKi = 7.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 554 6 1 5 2.9 O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I 10.1021/jm1009956
CHEMBL1774995 68860 0 None -52 7 Human 7.3 pKi = 7.3 Binding
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
ChEMBL 554 6 1 5 2.9 O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I 10.1021/jm1009956
277 8083 62 None -43 50 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/s0960-894x(00)00166-9
2913 8083 62 None -43 50 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/s0960-894x(00)00166-9
765 8083 62 None -43 50 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL516 8083 62 None -43 50 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/s0960-894x(00)00166-9
DB00434 8083 62 None -43 50 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1016/s0960-894x(00)00166-9
8431 8266 9 None -22 5 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
9843179 8266 9 None -22 5 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
CHEMBL69257 8266 9 None -22 5 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10.1021/jm030841r
277 8083 62 None -63 50 Human 7.3 pKi = 7.3 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1021/jm030841r
2913 8083 62 None -63 50 Human 7.3 pKi = 7.3 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1021/jm030841r
765 8083 62 None -63 50 Human 7.3 pKi = 7.3 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1021/jm030841r
CHEMBL516 8083 62 None -63 50 Human 7.3 pKi = 7.3 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1021/jm030841r
DB00434 8083 62 None -63 50 Human 7.3 pKi = 7.3 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1021/jm030841r
155549018 181021 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4548926 181021 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1 10.1016/j.bmcl.2016.06.080
191 7191 98 None -41 29 Human 6.3 pKi = 6.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1021/jm030030n
201 7191 98 None -41 29 Human 6.3 pKi = 6.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1021/jm030030n
2170 7191 98 None -41 29 Human 6.3 pKi = 6.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1021/jm030030n
CHEMBL1113 7191 98 None -41 29 Human 6.3 pKi = 6.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1021/jm030030n
DB00543 7191 98 None -41 29 Human 6.3 pKi = 6.3 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1021/jm030030n
44439399 154170 0 None -2 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 422 5 0 5 4.8 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL392970 154170 0 None -2 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 422 5 0 5 4.8 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2 10.1016/j.bmcl.2007.01.093
59752538 187931 0 None -251 4 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 339 3 1 4 3.7 CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4760784 187931 0 None -251 4 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 339 3 1 4 3.7 CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
156308 176062 5 None -2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 354 2 0 4 3.2 COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4 10.1016/j.bmcl.2007.01.093
CHEMBL441356 176062 5 None -2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 354 2 0 4 3.2 COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4 10.1016/j.bmcl.2007.01.093
10287730 10309 40 None -630 12 Human 6.3 pKi = 6.3 Binding
Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
77 10309 40 None -630 12 Human 6.3 pKi = 6.3 Binding
Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
CHEMBL425190 10309 40 None -630 12 Human 6.3 pKi = 6.3 Binding
Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
11304596 63170 0 None -3162 9 Human 6.3 pKi = 6.3 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 416 5 0 5 3.9 Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1631542 63170 0 None -3162 9 Human 6.3 pKi = 6.3 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 416 5 0 5 3.9 Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 10.1021/jm100714c
134133633 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3899822 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
CHEMBL3991400 161371 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 407 5 0 1 6.9 Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1 10.1016/j.bmc.2016.09.019
1220 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.ejmech.2019.111705
31 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.ejmech.2019.111705
7 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.ejmech.2019.111705
CHEMBL56 6975 55 None -208 44 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1016/j.ejmech.2019.111705
135367400 170750 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4207901 170750 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
127052778 147623 0 None -3 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 505 9 0 5 6.3 O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819403 147623 0 None -3 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 505 9 0 5 6.3 O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
5242341 204935 2 None -30 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 0 5 3.7 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL574827 204935 2 None -30 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 396 6 0 5 3.7 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2015.02.042
135367400 170750 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4207901 170750 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 228 1 1 3 2.3 Cc1cccc(-c2noc3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
46204733 131350 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 264 3 1 3 2.9 Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1 nan
CHEMBL3640579 131350 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 264 3 1 3 2.9 Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1 nan
46204733 131350 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 264 3 1 3 2.9 Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1 nan
CHEMBL3640579 131350 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 264 3 1 3 2.9 Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1 nan
155552213 183437 0 None -54 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4546775 183437 0 None -54 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4598090 183437 0 None -54 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 481 8 0 3 6.5 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.bmc.2019.06.028
164615243 191989 0 None -21 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4857676 191989 0 None -21 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
90654671 116869 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 466 8 1 5 3.1 CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235743 116869 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 466 8 1 5 3.1 CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
145984511 172403 0 None -5 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 493 6 0 7 3.8 O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4243497 172403 0 None -5 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 493 6 0 7 3.8 O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
156016856 184455 0 None -39 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 295 2 0 1 4.4 Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2 10.1016/j.bmc.2019.115262
CHEMBL4641769 184455 0 None -39 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 295 2 0 1 4.4 Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2 10.1016/j.bmc.2019.115262
155513438 176508 0 None -10 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 346 6 3 3 4.8 Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4438434 176508 0 None -10 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 346 6 3 3 4.8 Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
56945042 164820 0 None -4 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4085802 164820 0 None -4 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
44424659 92545 0 None -4 2 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 474 8 0 9 2.1 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229231 92545 0 None -4 2 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 474 8 0 9 2.1 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL2448068 92545 0 None -4 2 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 474 8 0 9 2.1 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2007.05.017
127052467 147629 0 None -1 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 1 1 4.5 c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 10.1016/j.bmc.2016.05.053
CHEMBL3819494 147629 0 None -1 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 1 1 4.5 c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 10.1016/j.bmc.2016.05.053
11747350 114109 0 None -25 10 Human 6.3 pKi = 6.3 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 260 5 1 3 2.4 CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C 10.1021/jm010943m
CHEMBL317535 114109 0 None -25 10 Human 6.3 pKi = 6.3 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 260 5 1 3 2.4 CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C 10.1021/jm010943m
118736366 125716 0 None -257 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 465 6 1 10 1.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2015.04.046
CHEMBL3423330 125716 0 None -257 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 465 6 1 10 1.3 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1 10.1016/j.ejmech.2015.04.046
25263297 191116 0 None -645 4 Human 5.3 pKi = 5.3 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 394 5 2 6 2.7 NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12 10.1016/j.bmcl.2009.03.071
CHEMBL484345 191116 0 None -645 4 Human 5.3 pKi = 5.3 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 394 5 2 6 2.7 NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12 10.1016/j.bmcl.2009.03.071
135464118 99835 0 None -14 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 304 1 4 2 1.9 N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1 10.1016/j.bmc.2013.09.011
CHEMBL2442272 99835 0 None -14 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 304 1 4 2 1.9 N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1 10.1016/j.bmc.2013.09.011
122483262 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3763883 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765837 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
60167452 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL2037526 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
6604117 194626 6 None -5 6 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 325 5 2 3 3.8 C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1021/acs.jmedchem.0c01912
CHEMBL2062340 194626 6 None -5 6 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 325 5 2 3 3.8 C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1021/acs.jmedchem.0c01912
CHEMBL49623 194626 6 None -5 6 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 325 5 2 3 3.8 C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1021/acs.jmedchem.0c01912
122483262 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3763883 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765837 144867 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 370 7 0 3 5.7 CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
155562918 181962 0 None -5 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4570584 181962 0 None -5 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 314 4 1 7 1.1 Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
162674513 190557 0 None -12 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4798559 190557 0 None -12 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4804009 190557 0 None -12 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 437 9 1 4 5.3 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
122181340 128660 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 460 7 1 4 4.2 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590092 128660 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 460 7 1 4 4.2 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
162661627 190488 0 None -7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 11 1 5 3.7 COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4778919 190488 0 None -7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 11 1 5 3.7 COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803268 190488 0 None -7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 425 11 1 5 3.7 COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
118464425 145087 0 None -13 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 357 3 2 7 2.8 CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
CHEMBL3770981 145087 0 None -13 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method
ChEMBL 357 3 2 7 2.8 CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1 10.1021/acs.jmedchem.5b01631
44582677 188352 0 None -2 3 Human 5.3 pKi = 5.3 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 432 10 1 6 3.9 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL476838 188352 0 None -2 3 Human 5.3 pKi = 5.3 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 432 10 1 6 3.9 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/j.bmc.2009.03.021
60167452 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037526 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
60167452 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL2037526 82129 0 None -28 8 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 448 7 1 6 4.1 O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
46205372 131364 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 3 1 2 3.7 COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1 nan
CHEMBL3640592 131364 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 289 3 1 2 3.7 COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1 nan
10904975 171646 0 None 17 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 379 7 1 6 3.7 O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL422008 171646 0 None 17 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 379 7 1 6 3.7 O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O 10.1021/jm020994z
11327137 73514 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 403 8 1 5 2.5 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm049743b
CHEMBL185762 73514 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 403 8 1 5 2.5 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm049743b
46205372 131364 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 3 1 2 3.7 COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1 nan
CHEMBL3640592 131364 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 289 3 1 2 3.7 COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1 nan
CHEMBL5094680 222289 0 None -3 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
137631892 163164 0 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4066426 163164 0 None 2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
137660741 166148 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 4.9 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4100470 166148 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 4.9 O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
145985718 172304 0 None -7 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 521 6 0 7 4.6 O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4241081 172304 0 None -7 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 521 6 0 7 4.6 O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
118626169 172354 0 None -7 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4242268 172354 0 None -7 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
134147124 156759 0 None 5 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 512 10 1 5 4.6 O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3950020 156759 0 None 5 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 512 10 1 5 4.6 O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2016.05.005
145975106 170440 0 None 30 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 9 1 4 5.2 O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.bmc.2017.03.057
CHEMBL4204459 170440 0 None 30 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 9 1 4 5.2 O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1016/j.bmc.2017.03.057
145972875 171507 0 None 33 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 9 1 4 4.2 CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4217506 171507 0 None 33 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 9 1 4 4.2 CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2017.03.057
109026949 181385 1 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 392 6 0 4 2.5 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4557369 181385 1 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 392 6 0 4 2.5 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2016.06.080
54758296 72778 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 426 7 1 2 6.0 CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
CHEMBL1836793 72778 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 426 7 1 2 6.0 CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21 10.1021/jm200547z
127052467 147629 0 None -1 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 1 1 4.5 c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 10.1016/j.bmc.2016.05.053
CHEMBL3819494 147629 0 None -1 7 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 1 1 4.5 c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 10.1016/j.bmc.2016.05.053
122178702 128146 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 387 6 0 5 3.8 COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581247 128146 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 387 6 0 5 3.8 COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL5094680 222289 0 None -3 8 Human 7.3 pKi = 7.3 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
135367820 171600 0 None 8 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None 8 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
11257340 128815 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 374 7 1 4 2.7 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2 10.1021/jm049743b
CHEMBL359538 128815 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 374 7 1 4 2.7 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2 10.1021/jm049743b
66801624 163281 0 None -2 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 6 2 3 5.4 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
CHEMBL4067700 163281 0 None -2 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 479 6 2 3 5.4 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
11568826 139576 0 None -446 8 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor
ChEMBL 460 4 0 8 2.8 CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 10.1016/j.bmcl.2005.04.077
CHEMBL370110 139576 0 None -446 8 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor
ChEMBL 460 4 0 8 2.8 CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 10.1016/j.bmcl.2005.04.077
156010209 183933 0 None -4 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 251 2 0 1 3.8 CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4634062 183933 0 None -4 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 251 2 0 1 3.8 CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
164620748 193024 0 None -147 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 396 5 1 7 3.0 CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
CHEMBL4873623 193024 0 None -147 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 396 5 1 7 3.0 CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
164620748 193024 0 None -147 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4873623 193024 0 None -147 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
16026344 29022 4 None -1 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 373 2 0 3 5.0 O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21 10.1016/j.bmcl.2015.03.049
CHEMBL1323386 29022 4 None -1 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 373 2 0 3 5.0 O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21 10.1016/j.bmcl.2015.03.049
155555506 181161 0 None -8 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 330 6 1 2 5.1 CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1 10.1016/j.ejmech.2019.111857
CHEMBL4552041 181161 0 None -8 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 330 6 1 2 5.1 CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1 10.1016/j.ejmech.2019.111857
46205041 131354 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 337 5 1 3 4.0 Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1 nan
CHEMBL3640582 131354 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 337 5 1 3 4.0 Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1 nan
46205041 131354 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 337 5 1 3 4.0 Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1 nan
CHEMBL3640582 131354 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 337 5 1 3 4.0 Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1 nan
164624803 192991 0 None -28 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4873127 192991 0 None -28 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
145978472 170382 0 None 14 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 438 4 1 4 2.7 O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1 10.1016/j.bmcl.2018.06.019
CHEMBL4203581 170382 0 None 14 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 438 4 1 4 2.7 O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1 10.1016/j.bmcl.2018.06.019
127027388 144429 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 437 8 1 5 3.6 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1 10.1016/j.ejmech.2015.11.040
CHEMBL3758378 144429 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 437 8 1 5 3.6 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1 10.1016/j.ejmech.2015.11.040
127042841 143783 0 None 3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 488 9 0 4 5.1 CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3746083 143783 0 None 3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 488 9 0 4 5.1 CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.11.041
76284193 153375 0 None 19 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 444 10 1 5 3.6 O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1016/j.ejmech.2016.05.005
CHEMBL3923145 153375 0 None 19 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 444 10 1 5 3.6 O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 10.1016/j.ejmech.2016.05.005
156012741 184066 0 None -2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 477 8 0 4 4.4 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2020.115459
CHEMBL4636435 184066 0 None -2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 477 8 0 4 4.4 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2020.115459
155538367 179160 0 None 30 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 263 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4476372 179160 0 None 30 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 263 2 1 2 3.8 CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12 10.1016/j.ejmech.2019.03.017
155541872 183464 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4519312 183464 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4598357 183464 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 447 8 0 3 5.8 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2019.06.028
44408820 147683 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 369 6 0 3 4.3 O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL382163 147683 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 369 6 0 3 4.3 O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
24854370 163849 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL407412 163849 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
135367820 171600 0 None 8 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218672 171600 0 None 8 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 232 1 1 3 2.2 Fc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
134130462 149091 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 390 7 0 5 3.7 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3885389 149091 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 390 7 0 5 3.7 Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2016.12.039
44439400 97989 0 None 2 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 7 0 4 5.2 CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
CHEMBL240023 97989 0 None 2 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 408 7 0 4 5.2 CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21 10.1016/j.bmcl.2007.01.093
138691317 178316 0 None 5 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 211 2 1 2 3.1 CCn1cncc1-c1c[nH]c2ccccc12 10.1016/j.ejmech.2019.03.017
CHEMBL4464377 178316 0 None 5 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 211 2 1 2 3.1 CCn1cncc1-c1c[nH]c2ccccc12 10.1016/j.ejmech.2019.03.017
155548677 180507 0 None -257 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 7 3 4 4.8 COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4536315 180507 0 None -257 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 7 3 4 4.8 COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1 10.1016/j.ejmech.2019.111857
46204419 131338 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 331 5 0 3 4.5 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1 nan
CHEMBL3640567 131338 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 331 5 0 3 4.5 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1 nan
46204419 131338 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 331 5 0 3 4.5 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1 nan
CHEMBL3640567 131338 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 331 5 0 3 4.5 COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1 nan
53323535 63799 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644487 63799 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 356 3 1 2 5.2 Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1 10.1016/j.bmcl.2010.11.078
145975778 170360 0 None 4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 374 7 1 4 2.8 Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00828
CHEMBL4203312 170360 0 None 4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 374 7 1 4 2.8 Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00828
136118659 83030 0 None -3 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 346 1 1 2 2.7 C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C 10.1016/j.bmc.2013.09.011
CHEMBL2058427 83030 0 None -3 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 346 1 1 2 2.7 C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C 10.1016/j.bmc.2013.09.011
71602523 96466 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 328 4 0 2 4.7 c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2376463 96466 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 328 4 0 2 4.7 c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
71602523 96466 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 328 4 0 2 4.7 c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
CHEMBL2376463 96466 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 328 4 0 2 4.7 c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2013.02.038
52952419 69355 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 358 5 0 5 3.3 O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12 10.1021/jm2000773
CHEMBL1782794 69355 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 358 5 0 5 3.3 O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12 10.1021/jm2000773
10662302 106124 0 None -2 5 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 304 1 1 2 3.0 CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
CHEMBL282375 106124 0 None -2 5 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
ChEMBL 304 1 1 2 3.0 CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 10.1021/jm9911433
24768519 99638 0 None 1 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 461 8 1 3 5.9 CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243953 99638 0 None 1 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 461 8 1 3 5.9 CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
44393053 72039 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 349 8 2 6 3.8 Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1 10.1016/j.bmcl.2004.06.008
CHEMBL182805 72039 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 349 8 2 6 3.8 Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1 10.1016/j.bmcl.2004.06.008
11372669 74192 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 388 8 0 4 3.2 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1 10.1021/jm049743b
CHEMBL188876 74192 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 388 8 0 4 3.2 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1 10.1021/jm049743b
76336184 113050 0 None 3 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 367 4 0 3 5.0 c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121434 113050 0 None 3 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 367 4 0 3 5.0 c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3139017 113050 0 None 3 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 367 4 0 3 5.0 c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
127026443 144616 0 None 85 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 1 4 3.9 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759925 144616 0 None 85 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 7 1 4 3.9 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2015.11.040
134139826 153310 0 None 12 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 487 10 1 6 3.6 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3922670 153310 0 None 12 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 487 10 1 6 3.6 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
156012823 184189 0 None -2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 548 11 0 6 6.2 Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1 10.1016/j.bmc.2020.115459
CHEMBL4638388 184189 0 None -2 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 548 11 0 6 6.2 Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1 10.1016/j.bmc.2020.115459
21048822 146997 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 377 6 0 3 4.3 CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
CHEMBL380511 146997 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 377 6 0 3 4.3 CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
23661667 92539 0 None -4 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
CHEMBL1203946 92539 0 None -4 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229181 92539 0 None -4 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2007.05.017
66801115 118841 0 None -5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 506 7 1 7 4.7 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3289959 118841 0 None -5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 506 7 1 7 4.7 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
122178711 128155 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 509 6 0 5 5.8 COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
CHEMBL3581256 128155 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 509 6 0 5 5.8 COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C 10.1021/np500893h
25108475 194264 0 None -2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 419 8 0 3 5.0 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL494119 194264 0 None -2 3 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 419 8 0 3 5.0 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 10.1021/jm800615e
23661667 92539 0 None -4 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2014.11.008
CHEMBL1203946 92539 0 None -4 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2014.11.008
CHEMBL229181 92539 0 None -4 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 470 9 0 10 1.4 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1 10.1016/j.bmc.2014.11.008
10333670 101561 0 None -1 5 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL253319 101561 0 None -1 5 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
155565209 182370 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4579764 182370 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 426 6 0 4 3.2 O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2016.06.080
155535154 178821 0 None -10 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 556 9 1 7 5.2 COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1 10.1016/j.ejmech.2019.07.027
CHEMBL4471755 178821 0 None -10 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method
ChEMBL 556 9 1 7 5.2 COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1 10.1016/j.ejmech.2019.07.027
145966154 170966 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 402 8 1 4 3.6 CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4210708 170966 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 402 8 1 4 3.6 CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
122483244 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764136 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765843 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
44448054 101560 0 None 1 6 Human 7.3 pKi = 7.3 Binding
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5 10.1021/jm060959i
CHEMBL253318 101560 0 None 1 6 Human 7.3 pKi = 7.3 Binding
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
ChEMBL 276 0 1 2 2.8 CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5 10.1021/jm060959i
132503215 164529 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4082456 164529 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 5.2 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmc.2017.04.046
57392107 75199 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2011.09.044
CHEMBL1917345 75199 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2011.09.044
145966418 171020 0 None 6 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4211253 171020 0 None 6 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 410 4 1 4 3.1 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2 10.1016/j.bmcl.2018.06.019
46205703 131375 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 1 1 4.0 Cc1ccc(-c2ccccc2C2CCNC2)cc1C nan
CHEMBL3640603 131375 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 251 2 1 1 4.0 Cc1ccc(-c2ccccc2C2CCNC2)cc1C nan
46205703 131375 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 1 1 4.0 Cc1ccc(-c2ccccc2C2CCNC2)cc1C nan
CHEMBL3640603 131375 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 251 2 1 1 4.0 Cc1ccc(-c2ccccc2C2CCNC2)cc1C nan
44408987 83334 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 335 6 0 3 3.9 CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1 10.1016/j.bmcl.2005.11.067
CHEMBL206269 83334 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 335 6 0 3 3.9 CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1 10.1016/j.bmcl.2005.11.067
122483244 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764136 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765843 144873 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.7 CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
5280953 104137 109 None -6 8 Human 5.3 pKi = 5.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 212 1 1 2 3.0 COc1ccc2c(c1)[nH]c1c(C)nccc12 10.1016/j.bmcl.2003.09.027
CHEMBL269538 104137 109 None -6 8 Human 5.3 pKi = 5.3 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 212 1 1 2 3.0 COc1ccc2c(c1)[nH]c1c(C)nccc12 10.1016/j.bmcl.2003.09.027
3564 124926 86 None -3 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 214 1 1 2 2.5 COc1ccc2c3c([nH]c2c1)C(C)=NCC3 10.1021/acs.jmedchem.0c01887
CHEMBL1494278 124926 86 None -3 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 214 1 1 2 2.5 COc1ccc2c3c([nH]c2c1)C(C)=NCC3 10.1021/acs.jmedchem.0c01887
CHEMBL340807 124926 86 None -3 4 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay
ChEMBL 214 1 1 2 2.5 COc1ccc2c3c([nH]c2c1)C(C)=NCC3 10.1021/acs.jmedchem.0c01887
90654675 116873 0 None -5 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 450 8 1 5 2.4 COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235747 116873 0 None -5 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 450 8 1 5 2.4 COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
46233381 208703 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 257 5 0 2 4.0 CN(C)CCSc1ccccc1-c1ccccc1 10.1016/j.bmc.2010.01.035
CHEMBL607584 208703 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 257 5 0 2 4.0 CN(C)CCSc1ccccc1-c1ccccc1 10.1016/j.bmc.2010.01.035
137645501 164424 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
CHEMBL4081383 164424 0 None -1 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis
ChEMBL 532 6 0 5 4.9 O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmc.2017.04.046
127028798 144962 0 None 23 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 454 6 2 5 2.4 Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
CHEMBL3769612 144962 0 None 23 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 454 6 2 5 2.4 Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
127039593 143768 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 460 10 0 6 3.5 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3745882 143768 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 460 10 0 6 3.5 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1 10.1016/j.bmc.2015.11.041
127042539 143862 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 10 0 4 4.9 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747148 143862 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 474 10 0 4 4.9 CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1 10.1016/j.bmc.2015.11.041
71574306 93041 0 None -3 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 10.1016/j.ejmech.2012.11.042
CHEMBL2312639 93041 0 None -3 5 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 10.1016/j.ejmech.2012.11.042
57325520 78313 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949963 78313 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1962945 78313 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
135 9310 43 None -83 56 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm049632c
1796 9310 43 None -83 56 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm049632c
4184 9310 43 None -83 56 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm049632c
CHEMBL6437 9310 43 None -83 56 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm049632c
DB06148 9310 43 None -83 56 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm049632c
155532137 178473 0 None 16 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 5 4.3 O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4466596 178473 0 None 16 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 432 7 1 5 4.3 O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
168283140 197878 0 None -34 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 463 7 0 8 3.3 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5187742 197878 0 None -34 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 463 7 0 8 3.3 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
10365873 74025 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 438 8 0 4 4.3 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm049743b
CHEMBL188036 74025 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 438 8 0 4 4.3 CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm049743b
127052778 147623 0 None -3 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 505 9 0 5 6.3 O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819403 147623 0 None -3 5 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 505 9 0 5 6.3 O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
18377342 113890 0 None - 1 Human 6.3 pKi = 6.3 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 2 3 3.2 O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL316039 113890 0 None - 1 Human 6.3 pKi = 6.3 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 2 3 3.2 O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3 10.1016/s0960-894x(02)00485-7
145947762 174477 0 None -2 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 500 8 2 6 2.7 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4170484 174477 0 None -2 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 500 8 2 6 2.7 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4302327 174477 0 None -2 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 500 8 2 6 2.7 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
42618256 188374 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 428 6 0 6 3.6 COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
CHEMBL477065 188374 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 428 6 0 6 3.6 COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1 10.1016/j.bmcl.2009.02.008
90654692 116855 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 438 6 1 5 2.8 CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235729 116855 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 438 6 1 5 2.8 CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
155547197 180374 0 None -758 7 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 341 6 0 4 3.4 O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
CHEMBL4533305 180374 0 None -758 7 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 341 6 0 4 3.4 O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2020.115943
145983468 172215 0 None -5 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 493 6 0 7 3.8 O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4238897 172215 0 None -5 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 493 6 0 7 3.8 O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
90656677 119380 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 388 7 1 5 2.3 CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262402 119380 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 388 7 1 5 2.3 CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3302044 119380 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 388 7 1 5 2.3 CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1 10.1016/j.ejmech.2014.04.034
44424666 151149 0 None 5 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 425 8 0 8 2.1 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
CHEMBL390580 151149 0 None 5 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 425 8 0 8 2.1 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
118706299 127315 0 None -64 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 269 1 3 2 2.3 N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310121 127315 0 None -64 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 269 1 3 2 2.3 N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545472 127315 0 None -64 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 269 1 3 2 2.3 N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2 10.1016/j.bmc.2014.05.027
66801259 118872 0 None 2 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 471 8 1 8 3.3 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
CHEMBL3289989 118872 0 None 2 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 471 8 1 8 3.3 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12 10.1021/jm401895u
44401194 78070 0 None -7 7 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 313 2 0 3 4.1 CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL195706 78070 0 None -7 7 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 313 2 0 3 4.1 CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
118713594 121157 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 365 7 0 5 3.6 O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331263 121157 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 365 7 0 5 3.6 O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
44340882 16286 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 392 5 2 5 2.5 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL112150 16286 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 392 5 2 5 2.5 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1 10.1016/s0960-894x(02)00690-x
155554837 181415 0 None -4 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 4 0 4 3.8 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 10.1016/j.bmc.2020.115943
CHEMBL4558031 181415 0 None -4 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 4 0 4 3.8 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 10.1016/j.bmc.2020.115943
168283630 198068 0 None -57 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 458 6 0 6 3.6 N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.ejmech.2022.114193
CHEMBL5190788 198068 0 None -57 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
ChEMBL 458 6 0 6 3.6 N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.ejmech.2022.114193
49783209 24381 0 None -10000 26 Human 5.2 pKi = 5.2 Binding
Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
CHEMBL1258223 24381 0 None -10000 26 Human 5.2 pKi = 5.2 Binding
Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
164618100 192139 0 None -128 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
CHEMBL4860275 192139 0 None -128 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2022.114645
44437331 97738 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 734 21 0 8 8.2 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
CHEMBL239530 97738 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 734 21 0 8 8.2 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 10.1016/j.bmc.2007.05.010
44424663 144922 0 None -5 2 Rat 5.2 pKi = 5.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 397 6 0 8 1.3 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
CHEMBL376773 144922 0 None -5 2 Rat 5.2 pKi = 5.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 397 6 0 8 1.3 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
CHEMBL4518342 220751 0 None - 1 Human 6.2 pKi = 6.2 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7
ChEMBL None None None CC(C)CC(=O)N1CCc2nc(-c3ccc(Br)cc3)nc(N(C)Cc3ccccc3)c2C1 10.6019/CHEMBL5212743
90654677 116875 0 None -7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 484 6 1 5 3.1 COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235749 116875 0 None -7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 484 6 1 5 3.1 COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1 10.1016/j.ejmech.2014.03.005
9978683 25446 0 None -363 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 406 3 1 5 3.3 CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1 10.1021/jm1007825
CHEMBL1277104 25446 0 None -363 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 406 3 1 5 3.3 CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1 10.1021/jm1007825
127041563 143782 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 448 7 0 4 4.3 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmc.2015.11.041
CHEMBL3746079 143782 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 448 7 0 4 4.3 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmc.2015.11.041
127041564 143829 0 None 4 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 7 0 6 2.9 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1 10.1016/j.bmc.2015.11.041
CHEMBL3746771 143829 0 None 4 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 434 7 0 6 2.9 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1 10.1016/j.bmc.2015.11.041
71453279 88207 0 None 1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 7 1 5 4.1 O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
CHEMBL2159475 88207 0 None 1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 7 1 5 4.1 O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1 10.1016/j.ejmech.2012.07.043
145976292 170411 0 None 31 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 468 9 1 4 4.7 O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2017.03.057
CHEMBL4203908 170411 0 None 31 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 468 9 1 4 4.7 O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2017.03.057
155554837 181415 0 None -4 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 4 0 4 3.8 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 10.1016/j.bmc.2020.115943
CHEMBL4558031 181415 0 None -4 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 387 4 0 4 3.8 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 10.1016/j.bmc.2020.115943
155562543 181951 0 None 1 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 4 0 4 3.2 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 10.1016/j.bmc.2020.115943
CHEMBL4570411 181951 0 None 1 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 4 0 4 3.2 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 10.1016/j.bmc.2020.115943
122178701 128145 0 None -1 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 425 9 0 5 5.4 CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581246 128145 0 None -1 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 425 9 0 5 5.4 CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
155562543 181951 0 None 1 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 4 0 4 3.2 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 10.1016/j.bmc.2020.115943
CHEMBL4570411 181951 0 None 1 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 353 4 0 4 3.2 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 10.1016/j.bmc.2020.115943
25263302 198763 0 None -4466 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 434 4 2 6 3.4 O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1 10.1016/j.bmcl.2009.03.071
CHEMBL520129 198763 0 None -4466 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 434 4 2 6 3.4 O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1 10.1016/j.bmcl.2009.03.071
56673112 73141 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 491 7 0 8 4.0 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851637 73141 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 491 7 0 8 4.0 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216275 73141 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 491 7 0 8 4.0 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1 10.1016/j.ejmech.2011.04.060
44408988 172846 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 336 6 0 4 2.4 CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1 10.1016/j.bmcl.2005.11.067
CHEMBL425767 172846 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 336 6 0 4 2.4 CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1 10.1016/j.bmcl.2005.11.067
155538814 180042 0 None -38 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 334 4 1 7 1.4 CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4524981 180042 0 None -38 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 334 4 1 7 1.4 CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1 10.1016/j.ejmech.2019.06.022
168283609 198016 0 None -2 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 418 10 5 8 3.1 COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5190020 198016 0 None -2 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 418 10 5 8 3.1 COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
155544139 180132 0 None -30 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 1.7 Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl 10.1016/j.ejmech.2019.06.022
CHEMBL4527124 180132 0 None -30 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 1.7 Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl 10.1016/j.ejmech.2019.06.022
122483228 144790 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764661 144790 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
155556527 181289 0 None -7 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 247 2 1 2 3.3 CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12 10.1016/j.ejmech.2019.03.017
CHEMBL4555115 181289 0 None -7 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 247 2 1 2 3.3 CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12 10.1016/j.ejmech.2019.03.017
72198014 96593 0 None -18 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 484 7 2 4 4.8 COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2013.02.033
CHEMBL2377443 96593 0 None -18 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 484 7 2 4 4.8 COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1 10.1016/j.ejmech.2013.02.033
71458624 88142 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 7 1 3 4.5 Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159315 88142 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 400 7 1 3 4.5 Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1 10.1016/j.ejmech.2012.07.043
145966199 171046 0 None 22 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 9 2 5 3.7 O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2017.03.057
CHEMBL4211665 171046 0 None 22 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 484 9 2 5 3.7 O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2017.03.057
44582675 196480 0 None 1 15 Human 7.2 pKi = 7.2 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL515472 196480 0 None 1 15 Human 7.2 pKi = 7.2 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
46206346 131387 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 351 4 1 3 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1 nan
CHEMBL3640614 131387 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 351 4 1 3 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1 nan
46206346 131387 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 351 4 1 3 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1 nan
CHEMBL3640614 131387 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 351 4 1 3 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1 nan
10992240 60322 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1 10.1021/jm020994z
CHEMBL160194 60322 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 368 8 1 5 3.6 COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1 10.1021/jm020994z
25130235 194366 1 None -169 11 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 294 2 1 6 1.3 CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1 10.1021/jm8005959
CHEMBL494678 194366 1 None -169 11 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 294 2 1 6 1.3 CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1 10.1021/jm8005959
122483228 144790 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764661 144790 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
164615340 192208 0 None -25 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4861431 192208 0 None -25 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
155530351 183063 0 None -6 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4464370 183063 0 None -6 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
CHEMBL4595115 183063 0 None -6 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method
ChEMBL 517 8 0 4 5.8 O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmc.2019.06.028
44393133 71622 1 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL182070 71622 1 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 318 7 2 4 4.3 CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
9945703 73455 1 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 336 7 2 4 4.4 CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
CHEMBL185437 73455 1 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 336 7 2 4 4.4 CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.007
2865 10915 73 None -12 53 Human 8.2 pKi = 8.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm400856t
59 10915 73 None -12 53 Human 8.2 pKi = 8.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm400856t
60854 10915 73 None -12 53 Human 8.2 pKi = 8.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm400856t
CHEMBL708 10915 73 None -12 53 Human 8.2 pKi = 8.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm400856t
DB00246 10915 73 None -12 53 Human 8.2 pKi = 8.2 Binding
Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1021/jm400856t
44456033 162346 3 None -4 8 Human 8.2 pKi = 8.2 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 195 0 2 3 2.0 C[C@@H]1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL404372 162346 3 None -4 8 Human 8.2 pKi = 8.2 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 195 0 2 3 2.0 C[C@@H]1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.078
10202089 202525 0 None 87 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 417 4 3 4 3.4 COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1 10.1016/j.bmcl.2009.06.038
CHEMBL557330 202525 0 None 87 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 417 4 3 4 3.4 COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1 10.1016/j.bmcl.2009.06.038
145985585 172668 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4249640 172668 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
71451459 88219 0 None 3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159487 88219 0 None 3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
145946947 174381 0 None 31 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 8 2 6 2.0 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4176950 174381 0 None 31 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 8 2 6 2.0 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4300976 174381 0 None 31 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 452 8 2 6 2.0 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
145947404 174449 0 None 16 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 468 8 2 7 1.7 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4163778 174449 0 None 16 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 468 8 2 7 1.7 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4301967 174449 0 None 16 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 468 8 2 7 1.7 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
138691314 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4216263 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1016/j.ejmech.2019.03.017
138691314 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1039/C8MD00313K
CHEMBL4216263 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1039/C8MD00313K
155537034 179064 0 None 36 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 240 2 2 3 1.7 Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1039/C8MD00313K
CHEMBL4474827 179064 0 None 36 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 240 2 2 3 1.7 Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12 10.1039/C8MD00313K
127039755 143431 0 None 14 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 470 8 1 4 4.8 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1039/C5MD00166H
CHEMBL3740055 143431 0 None 14 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 470 8 1 4 4.8 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1 10.1039/C5MD00166H
11151899 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2020.127669
8432 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2020.127669
CHEMBL4205783 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1016/j.bmcl.2020.127669
11323169 186746 0 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 269 2 1 3 3.1 Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4746737 186746 0 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 269 2 1 3 3.1 Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
56944953 166433 0 None -2 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4103725 166433 0 None -2 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 463 7 2 3 4.9 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
155563911 182195 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 534 10 1 7 4.1 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
CHEMBL4575904 182195 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 534 10 1 7 4.1 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 10.1016/j.bmc.2019.07.046
138691314 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1021/acs.jmedchem.7b01898
CHEMBL4216263 171415 1 None 173 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis
ChEMBL 337 2 1 2 3.7 CCn1cncc1-c1c[nH]c2ccc(I)cc12 10.1021/acs.jmedchem.7b01898
11153067 83527 1 None 34 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 375 6 0 3 4.7 O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL206748 83527 1 None 34 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 375 6 0 3 4.7 O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1 10.1016/j.bmcl.2005.11.067
5 6927 72 None -3 53 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
5202 6927 72 None -3 53 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
CHEMBL39 6927 72 None -3 53 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
DB08839 6927 72 None -3 53 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2016.07.029
25107516 193964 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 433 8 0 3 5.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
CHEMBL492282 193964 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 433 8 0 3 5.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 10.1021/jm800615e
25256850 196512 0 None 44 2 Human 8.2 pKi = 8.2 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 364 7 1 4 3.3 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL515780 196512 0 None 44 2 Human 8.2 pKi = 8.2 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 364 7 1 4 3.3 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.008
10917174 108959 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 439 7 1 3 5.6 C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL302766 108959 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 439 7 1 3 5.6 C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
11397799 91508 0 None -1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 1 4 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222864 91508 0 None -1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 421 8 1 4 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
9881600 61971 4 None 8 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmc.2010.01.035
CHEMBL161765 61971 4 None 8 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1 10.1016/j.bmc.2010.01.035
24963856 95120 0 None 363 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 253 4 0 1 4.1 Cc1cccc(C)c1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
CHEMBL234881 95120 0 None 363 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 253 4 0 1 4.1 Cc1cccc(C)c1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
44401164 76591 0 None -30 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL193639 76591 0 None -30 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
135398737 7745 93 None -7 90 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
38 7745 93 None -7 90 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
722 7745 93 None -7 90 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
CHEMBL42 7745 93 None -7 90 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
DB00363 7745 93 None -7 90 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm030030n
153287553 177883 0 None 79 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4457754 177883 0 None 79 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
66800991 118845 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 456 7 1 8 2.4 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
CHEMBL3289963 118845 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 456 7 1 8 2.4 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12 10.1021/jm401895u
66800910 118884 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 437 8 1 6 4.0 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3290000 118884 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 437 8 1 6 4.0 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 10.1021/jm401895u
1621 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm0341204
17 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm0341204
5761 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm0341204
CHEMBL263881 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm0341204
DB04829 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm0341204
11307899 85643 0 None -100 7 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 597 6 4 6 2.5 CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12 10.1021/jm0341204
CHEMBL2112882 85643 0 None -100 7 Human 8.2 pKi = 8.2 Binding
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
ChEMBL 597 6 4 6 2.5 CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12 10.1021/jm0341204
44341114 120167 0 None 14 2 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL331803 120167 0 None 14 2 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1 10.1016/s0960-894x(02)00690-x
133 9274 52 None -16 43 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/s0960-894x(00)00166-9
1723 9274 52 None -16 43 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/s0960-894x(00)00166-9
28693 9274 52 None -16 43 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/s0960-894x(00)00166-9
CHEMBL19215 9274 52 None -16 43 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/s0960-894x(00)00166-9
DB13520 9274 52 None -16 43 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/s0960-894x(00)00166-9
CHEMBL5081379 221525 0 None 1 9 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
134133064 151513 0 None 4 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 314 5 0 3 3.0 CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1 10.1016/j.bmc.2016.09.019
CHEMBL3908870 151513 0 None 4 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 314 5 0 3 3.0 CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1 10.1016/j.bmc.2016.09.019
153287553 177883 0 None 79 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4457754 177883 0 None 79 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
133 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.ejmech.2019.111705
1723 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.ejmech.2019.111705
28693 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.ejmech.2019.111705
CHEMBL19215 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.ejmech.2019.111705
DB13520 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.ejmech.2019.111705
133 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.bmcl.2010.03.012
1723 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.bmcl.2010.03.012
28693 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.bmcl.2010.03.012
CHEMBL19215 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.bmcl.2010.03.012
DB13520 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1016/j.bmcl.2010.03.012
133 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1021/jm030841r
1723 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1021/jm030841r
28693 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1021/jm030841r
CHEMBL19215 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1021/jm030841r
DB13520 9274 52 None -10 43 Human 8.2 pKi = 8.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 10.1021/jm030841r
22857296 35923 0 None 9 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 389 4 2 3 4.1 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
CHEMBL13816 35923 0 None 9 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 389 4 2 3 4.1 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
11465316 72036 0 None 26 2 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 369 8 0 4 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1 10.1016/j.bmcl.2004.11.013
CHEMBL182792 72036 0 None 26 2 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 369 8 0 4 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1 10.1016/j.bmcl.2004.11.013
11465316 72036 0 None 26 2 Rat 8.2 pKi = 8.2 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 369 8 0 4 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
CHEMBL182792 72036 0 None 26 2 Rat 8.2 pKi = 8.2 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 369 8 0 4 4.8 CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
9799318 113312 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 366 5 1 3 4.5 O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL314055 113312 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 366 5 1 3 4.5 O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
44341126 16241 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 376 5 1 4 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL111922 16241 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 376 5 1 4 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1 10.1016/s0960-894x(02)00690-x
44340883 16438 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 376 5 1 4 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1 10.1016/s0960-894x(02)00690-x
CHEMBL112876 16438 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
ChEMBL 376 5 1 4 2.8 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1 10.1016/s0960-894x(02)00690-x
10884717 211051 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 441 5 1 4 5.1 CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL71225 211051 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 441 5 1 4 5.1 CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
162657983 187827 0 None -26 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 10.1016/j.ejmech.2020.112149
CHEMBL4759492 187827 0 None -26 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 10.1016/j.ejmech.2020.112149
9799318 113312 0 None -1 4 Rat 8.2 pKi = 8.2 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 366 5 1 3 4.5 O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3 10.1021/jm0498102
CHEMBL314055 113312 0 None -1 4 Rat 8.2 pKi = 8.2 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 366 5 1 3 4.5 O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3 10.1021/jm0498102
134157171 160717 0 None 24 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 531 14 1 6 5.3 COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3983496 160717 0 None 24 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 531 14 1 6 5.3 COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
142601329 193296 5 None 61 7 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4877603 193296 5 None 61 7 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
156010865 183910 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4633786 183910 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 10.1016/j.bmc.2020.115578
11151899 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1021/acs.jmedchem.7b01898
8432 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1021/acs.jmedchem.7b01898
CHEMBL4205783 8918 13 None -5 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay
ChEMBL 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 10.1021/acs.jmedchem.7b01898
11186523 134289 0 None -4 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL366164 134289 0 None -4 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
24854269 164713 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 497 10 0 4 5.9 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1021/jm070279v
CHEMBL408451 164713 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 497 10 0 4 5.9 CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1021/jm070279v
1621 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
17 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
5761 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
CHEMBL263881 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
DB04829 9207 17 None -22 44 Human 8.2 pKi = 8.2 Binding
Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
90656712 117747 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 399 5 2 3 5.0 CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.04.034
CHEMBL3262395 117747 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 399 5 2 3 5.0 CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 10.1016/j.ejmech.2014.04.034
11432177 91897 0 None 1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/acs.jmedchem.5b00982
CHEMBL224820 91897 0 None 1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/acs.jmedchem.5b00982
44401164 76591 0 None -30 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL193639 76591 0 None -30 9 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.5 CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
142601329 193296 5 None 61 7 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
CHEMBL4877603 193296 5 None 61 7 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 276 2 2 3 2.5 Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 10.1021/acs.jmedchem.1c01093
11432177 91897 0 None 1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL224820 91897 0 None 1 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
54758298 72782 0 None -4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm200547z
CHEMBL1836857 72782 0 None -4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 401 6 1 3 4.5 O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm200547z
56943599 118863 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 8 1 6 4.5 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL3289980 118863 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 8 1 6 4.5 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 10.1021/jm401895u
CHEMBL5081379 221525 0 None 1 9 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
118728525 124498 0 None -6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 420 9 0 6 3.8 CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1 10.1016/j.bmcl.2015.02.042
CHEMBL3401488 124498 0 None -6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 420 9 0 6 3.8 CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1 10.1016/j.bmcl.2015.02.042
10562462 106468 1 None 5 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 247 0 0 1 3.3 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3 10.1021/jm9911433
CHEMBL284586 106468 1 None 5 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 247 0 0 1 3.3 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3 10.1021/jm9911433
76318011 112284 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 425 5 0 4 5.6 COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121422 112284 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 425 5 0 4 5.6 COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
60196079 88581 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 252 2 1 2 3.1 Cc1ccccc1-c1ccccc1N1CCNCC1 10.1021/jm3003679
CHEMBL2164329 88581 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 252 2 1 2 3.1 Cc1ccccc1-c1ccccc1N1CCNCC1 10.1021/jm3003679
24854039 102542 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 394 7 1 2 5.5 CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
CHEMBL258537 102542 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 394 7 1 2 5.5 CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 10.1021/jm200547z
56943891 118828 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 8 1 6 4.5 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
CHEMBL3289946 118828 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 498 8 1 6 4.5 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm401895u
10562462 106468 1 None 5 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 247 0 0 1 3.3 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3 10.1016/s0960-894x(00)00655-7
CHEMBL284586 106468 1 None 5 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 247 0 0 1 3.3 CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3 10.1016/s0960-894x(00)00655-7
44266160 214283 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 421 4 0 3 3.3 O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9446 214283 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 421 4 0 3 3.3 O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
162661903 188207 0 None -19 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 425 7 1 6 3.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 10.1016/j.ejmech.2020.112149
CHEMBL4764006 188207 0 None -19 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 425 7 1 6 3.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 10.1016/j.ejmech.2020.112149
24854103 102930 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm070279v
CHEMBL260551 102930 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm070279v
44393001 71635 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 348 8 3 6 3.7 CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL182121 71635 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 348 8 3 6 3.7 CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
71455083 88605 0 None -100 7 Human 7.2 pKi = 7.2 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 389 6 0 3 4.8 O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 10.1016/j.bmcl.2012.05.119
CHEMBL2164354 88605 0 None -100 7 Human 7.2 pKi = 7.2 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 389 6 0 3 4.8 O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 10.1016/j.bmcl.2012.05.119
22857296 35923 0 None -9 4 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 389 4 2 3 4.1 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
CHEMBL13816 35923 0 None -9 4 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 389 4 2 3 4.1 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 10.1021/jm030030n
11573726 78306 0 None -7 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 343 6 1 4 1.8 O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926750 78306 0 None -7 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 343 6 1 4 1.8 O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962912 78306 0 None -7 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 343 6 1 4 1.8 O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1 10.1021/jm2007886
76328896 113049 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 368 4 0 4 4.3 c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121432 113049 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 368 4 0 4 4.3 c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3139016 113049 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 368 4 0 4 4.3 c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1 10.1016/j.ejmech.2014.01.055
71458647 88188 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 9 1 4 4.0 CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159457 88188 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 434 9 1 4 4.0 CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.ejmech.2012.07.043
90644063 118812 0 None -2 10 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2020.115943
CHEMBL3289648 118812 0 None -2 10 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2020.115943
6918542 211703 24 None -537 10 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00453-4
CHEMBL76237 211703 24 None -537 10 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00453-4
156019939 184760 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 254 2 0 2 3.1 CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1 10.1016/j.bmc.2019.115262
CHEMBL4646100 184760 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 254 2 0 2 3.1 CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1 10.1016/j.bmc.2019.115262
11575479 101518 0 None -7 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor
ChEMBL 425 4 1 3 5.7 CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O 10.1016/j.bmcl.2007.11.045
CHEMBL253096 101518 0 None -7 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor
ChEMBL 425 4 1 3 5.7 CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O 10.1016/j.bmcl.2007.11.045
145978482 170410 0 None 2 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 436 8 1 4 4.2 O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4203872 170410 0 None 2 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 436 8 1 4 4.2 O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
168284975 198264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 404 5 0 6 3.5 COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5193580 198264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 404 5 0 6 3.5 COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
122483300 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765794 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765838 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
57391158 78332 0 None 10 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949979 78332 0 None 10 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963033 78332 0 None 10 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 444 7 1 5 3.4 O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.12.039
122483300 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765794 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
CHEMBL3765838 144868 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 384 8 0 3 6.1 CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1 10.1016/j.ejmech.2016.01.043
168277374 197148 0 None 9 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 441 8 4 6 4.6 Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5177186 197148 0 None 9 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 441 8 4 6 4.6 Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
168291906 198809 0 None -3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 452 8 0 5 4.8 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3 10.1016/j.ejmech.2022.114319
CHEMBL5201984 198809 0 None -3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 452 8 0 5 4.8 O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3 10.1016/j.ejmech.2022.114319
66803500 163218 0 None -24 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 459 8 3 4 4.4 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4066971 163218 0 None -24 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 459 8 3 4 4.4 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 10.1021/acs.jmedchem.7b00839
118736396 125728 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 497 6 0 10 1.3 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
CHEMBL3423378 125728 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 497 6 0 10 1.3 Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O 10.1016/j.ejmech.2015.04.046
162642955 188518 0 None 38 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 468 9 0 4 6.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4777209 188518 0 None 38 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 468 9 0 4 6.1 COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1 10.1016/j.ejmech.2020.112395
163196460 199470 3 None -56 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 394 4 1 7 3.4 CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1 10.1016/j.ejmech.2022.114645
CHEMBL5219240 199470 3 None -56 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay
ChEMBL 394 4 1 7 3.4 CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1 10.1016/j.ejmech.2022.114645
66801837 164307 0 None -6 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 507 8 2 3 6.1 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
CHEMBL4079972 164307 0 None -6 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 507 8 2 3 6.1 Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 10.1021/acs.jmedchem.7b00839
2867758 168821 7 None -1 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 339 6 1 2 5.5 Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1 10.1016/j.ejmech.2018.04.010
CHEMBL4160177 168821 7 None -1 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 339 6 1 2 5.5 Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1 10.1016/j.ejmech.2018.04.010
53377139 73154 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 413 6 0 6 3.5 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851703 73154 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 413 6 0 6 3.5 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3216068 73154 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 413 6 0 6 3.5 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2011.04.060
134130379 148983 0 None -5 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 402 8 0 5 3.9 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884137 148983 0 None -5 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 402 8 0 5 3.9 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2016.12.039
155568224 182900 0 None -4 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 350 4 1 7 2.2 CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4591878 182900 0 None -4 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 350 4 1 7 2.2 CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
122483251 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764364 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765851 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
122483251 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764364 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765851 144881 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 362 6 0 3 5.9 O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
76328894 113051 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 398 5 0 5 4.4 COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121431 113051 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 398 5 0 5 4.4 COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139018 113051 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 398 5 0 5 4.4 COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
164620912 192514 0 None -7 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 1 4 2.6 OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4866053 192514 0 None -7 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 341 4 1 4 2.6 OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
118709755 120323 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 368 8 0 2 5.0 O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
CHEMBL3321797 120323 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 368 8 0 2 5.0 O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1 10.1021/jm500880c
135398737 7745 93 None -7 90 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2015.09.045
38 7745 93 None -7 90 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2015.09.045
722 7745 93 None -7 90 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2015.09.045
CHEMBL42 7745 93 None -7 90 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2015.09.045
DB00363 7745 93 None -7 90 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2015.09.045
60165412 82134 0 None -17 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 379 7 0 5 4.5 O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
CHEMBL2037530 82134 0 None -17 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 379 7 0 5 4.5 O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1 10.1016/j.ejmech.2012.03.042
162666571 189086 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 460 10 0 6 5.2 COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4784167 189086 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 460 10 0 6 5.2 COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1 10.1016/j.ejmech.2020.112395
44582707 193777 0 None -5 4 Human 5.2 pKi = 5.2 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 430 10 0 6 4.1 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL490634 193777 0 None -5 4 Human 5.2 pKi = 5.2 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 430 10 0 6 4.1 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/j.bmc.2009.03.021
155519559 177160 0 None -3162 6 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1 10.1021/acsmedchemlett.6b00056
CHEMBL4447846 177160 0 None -3162 6 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1 10.1021/acsmedchemlett.6b00056
71452382 90569 0 None -199 10 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1 10.1016/j.bmcl.2012.08.046
CHEMBL2205812 90569 0 None -199 10 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 309 4 1 3 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1 10.1016/j.bmcl.2012.08.046
127051516 147635 0 None -26 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 420 6 1 5 4.0 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3819567 147635 0 None -26 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 420 6 1 5 4.0 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.06.011
164619216 192443 0 None -74 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4864863 192443 0 None -74 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 424 7 1 7 3.8 CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
118724645 127378 0 None -2 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 367 5 0 7 1.3 Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3361003 127378 0 None -2 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 367 5 0 7 1.3 Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3545907 127378 0 None -2 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 367 5 0 7 1.3 Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O 10.1016/j.bmc.2014.11.008
2470 10425 50 None -1096 58 Mouse 7.2 pKi = 7.2 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
3300 10425 50 None -1096 58 Mouse 7.2 pKi = 7.2 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
5265 10425 50 None -1096 58 Mouse 7.2 pKi = 7.2 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
99 10425 50 None -1096 58 Mouse 7.2 pKi = 7.2 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL267930 10425 50 None -1096 58 Mouse 7.2 pKi = 7.2 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
122181345 128665 0 None -1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 490 8 1 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590097 128665 0 None -1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 490 8 1 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1 10.1016/j.bmc.2015.04.026
11566574 78260 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 355 6 1 4 2.0 O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926753 78260 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 355 6 1 4 2.0 O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962487 78260 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 355 6 1 4 2.0 O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1 10.1021/jm2007886
25125374 184665 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 319 2 0 1 4.8 CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4644725 184665 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 319 2 0 1 4.8 CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmc.2019.115262
164627977 193212 0 None -12 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4876297 193212 0 None -12 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
156022183 184986 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 278 2 1 2 3.8 CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4649646 184986 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 278 2 1 2 3.8 CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3 10.1016/j.bmc.2020.115578
42626361 193558 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 363 7 0 3 3.6 O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
CHEMBL489029 193558 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 363 7 0 3 3.6 O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
42625353 199844 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 393 8 0 4 3.6 COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1 10.1021/jm8014553
CHEMBL522417 199844 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 393 8 0 4 3.6 COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1 10.1021/jm8014553
11348477 133564 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 343 6 0 5 1.5 COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL365412 133564 0 None -2 2 Rat 7.2 pKi = 7.2 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 343 6 0 5 1.5 COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
10991109 211946 1 None -6 5 Human 7.2 pKi = 7.2 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 329 5 0 2 4.1 O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 10.1021/jm0200411
CHEMBL78218 211946 1 None -6 5 Human 7.2 pKi = 7.2 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 329 5 0 2 4.1 O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 10.1021/jm0200411
9979252 105293 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 415 7 0 4 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL276206 105293 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 415 7 0 4 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/s0960-894x(00)00166-9
10436045 10289 4 None -19 13 Human 7.2 pKi = 7.2 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
782 10289 4 None -19 13 Human 7.2 pKi = 7.2 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
CHEMBL432713 10289 4 None -19 13 Human 7.2 pKi = 7.2 Binding
Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
49850872 63232 0 None -251 9 Human 7.2 pKi = 7.2 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 388 5 1 4 3.9 CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
CHEMBL1632206 63232 0 None -251 9 Human 7.2 pKi = 7.2 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 388 5 1 4 3.9 CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 10.1021/jm100714c
90656714 117744 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 321 4 2 3 3.2 Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262390 117744 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 321 4 2 3 3.2 Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2014.04.034
37459 7533 13 None -194 24 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 10.1016/s0960-894x(00)00166-9
62 7533 13 None -194 24 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 10.1016/s0960-894x(00)00166-9
CHEMBL8514 7533 13 None -194 24 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 10.1016/s0960-894x(00)00166-9
135 9310 43 None -50 56 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(00)00166-9
1796 9310 43 None -50 56 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(00)00166-9
4184 9310 43 None -50 56 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(00)00166-9
CHEMBL6437 9310 43 None -50 56 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(00)00166-9
DB06148 9310 43 None -50 56 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1016/s0960-894x(00)00166-9
9979252 105293 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 415 7 0 4 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
CHEMBL276206 105293 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 415 7 0 4 4.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1021/jm030841r
44268087 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
CHEMBL13049 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
44268087 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
CHEMBL13049 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
117209912 192116 1 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4859827 192116 1 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
164627977 193212 0 None -12 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4876297 193212 0 None -12 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 355 4 0 4 3.3 O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL5077178 221266 0 None -4 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)cc1 10.1021/acs.jmedchem.1c00497
90644063 118812 0 None -2 10 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2020.115943
CHEMBL3289648 118812 0 None -2 10 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2020.115943
90656714 117744 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 321 4 2 3 3.2 Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262390 117744 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 321 4 2 3 3.2 Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1 10.1016/j.ejmech.2014.04.034
242 7258 124 None -15 51 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm070516u
34 7258 124 None -15 51 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm070516u
60795 7258 124 None -15 51 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm070516u
CHEMBL1112 7258 124 None -15 51 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm070516u
DB01238 7258 124 None -15 51 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/jm070516u
2337 10030 77 None -28 62 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1021/jm070516u
50 10030 77 None -28 62 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1021/jm070516u
5002 10030 77 None -28 62 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1021/jm070516u
CHEMBL716 10030 77 None -28 62 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1021/jm070516u
DB01224 10030 77 None -28 62 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1021/jm070516u
9887537 91120 43 None -79 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 405 4 0 5 4.0 Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 10.1021/jm070516u
CHEMBL221692 91120 43 None -79 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 405 4 0 5 4.0 Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 10.1021/jm070516u
CHEMBL4751170 91120 43 None -79 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 405 4 0 5 4.0 Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 10.1021/jm070516u
135 9310 43 None -83 56 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030841r
1796 9310 43 None -83 56 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030841r
4184 9310 43 None -83 56 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030841r
CHEMBL6437 9310 43 None -83 56 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030841r
DB06148 9310 43 None -83 56 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030841r
37461 23906 14 None -70 8 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 361 0 1 2 4.8 CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1 10.1021/jm030841r
CHEMBL1255588 23906 14 None -70 8 Human 7.2 pKi = 7.2 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 361 0 1 2 4.8 CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1 10.1021/jm030841r
90656688 117764 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 338 7 2 4 2.4 NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262420 117764 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 338 7 2 4 2.4 NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
11329254 91991 0 None 2 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 450 9 1 5 4.5 O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL225571 91991 0 None 2 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 450 9 1 5 4.5 O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 10.1021/jm049702f
17053 208826 7 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 244 4 1 2 2.8 COc1ccc2[nH]cc(CCN3CCCC3)c2c1 10.1021/jm030826m
CHEMBL608537 208826 7 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 244 4 1 2 2.8 COc1ccc2[nH]cc(CCN3CCCC3)c2c1 10.1021/jm030826m
11485965 52615 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 385 6 0 3 4.4 O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
CHEMBL153132 52615 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 385 6 0 3 4.4 O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
11793826 24824 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
CHEMBL12654 24824 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm970519e
11793826 24824 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
CHEMBL12654 24824 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
ChEMBL 374 6 0 3 4.0 C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1016/s0960-894x(00)00166-9
44368384 51180 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
CHEMBL151858 51180 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
ChEMBL 373 6 0 3 4.8 CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 10.1021/jm030841r
127051516 147635 0 None -26 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 420 6 1 5 4.0 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.06.011
CHEMBL3819567 147635 0 None -26 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 420 6 1 5 4.0 O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 10.1016/j.bmc.2016.06.011
9935387 106218 0 None -794 14 Human 6.2 pKi = 6.2 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 10.1016/s0960-894x(02)00172-5
CHEMBL282971 106218 0 None -794 14 Human 6.2 pKi = 6.2 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 10.1016/s0960-894x(02)00172-5
90654693 116856 0 None -2 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 388 8 1 5 1.5 COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235730 116856 0 None -2 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 388 8 1 5 1.5 COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
156010396 183906 0 None 1 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 392 5 1 4 4.2 COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4633765 183906 0 None 1 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 392 5 1 4 4.2 COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
71457264 89396 0 None -20 6 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 447 5 1 6 4.4 COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1 10.1021/jm300955x
CHEMBL2179217 89396 0 None -20 6 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 447 5 1 6 4.4 COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1 10.1021/jm300955x
2136365 124705 21 None -5 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 404 3 0 5 4.5 Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403331 124705 21 None -5 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 404 3 0 5 4.5 Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL5090884 222356 0 None 1 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096072 222356 0 None 1 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
11610908 74818 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 394 7 1 3 4.0 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1914488 74818 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 394 7 1 3 4.0 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
145977467 170770 0 None 9 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4208185 170770 0 None 9 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 486 7 1 4 3.1 O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
117209912 192116 1 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4859827 192116 1 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 262 2 2 3 2.1 Clc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
11432453 91972 0 None 1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
CHEMBL225441 91972 0 None 1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 451 9 1 5 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1 10.1021/jm049702f
76324975 111792 0 None 8 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 473 11 1 6 4.2 COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
CHEMBL3113604 111792 0 None 8 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 473 11 1 6 4.2 COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1 10.1016/j.bmc.2014.01.016
72549768 120850 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 443 9 1 4 4.6 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326977 120850 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 443 9 1 4 4.6 COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL5090884 222356 0 None 1 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5096072 222356 0 None 1 7 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
162644013 188618 0 None -16 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 473 7 1 6 4.5 Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 10.1016/j.ejmech.2020.112149
CHEMBL4778418 188618 0 None -16 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 473 7 1 6 4.5 Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 10.1016/j.ejmech.2020.112149
162666577 189112 0 None -47 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 455 7 1 6 4.3 Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 10.1016/j.ejmech.2020.112149
CHEMBL4784414 189112 0 None -47 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 455 7 1 6 4.3 Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 10.1016/j.ejmech.2020.112149
155562519 181991 0 None -131 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 516 8 2 4 5.3 COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1 10.1016/j.ejmech.2019.111736
CHEMBL4571321 181991 0 None -131 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
ChEMBL 516 8 2 4 5.3 COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1 10.1016/j.ejmech.2019.111736
155541072 179743 0 None 1 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 290 3 2 4 1.7 CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12 10.1039/C8MD00313K
CHEMBL4517552 179743 0 None 1 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 290 3 2 4 1.7 CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12 10.1039/C8MD00313K
134134279 150432 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 257 5 1 3 3.1 CNCc1ccc(OC)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
CHEMBL3899934 150432 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 257 5 1 3 3.1 CNCc1ccc(OC)c(-c2ccccc2OC)c1 10.1016/j.ejmech.2016.07.029
76332575 113053 0 None -4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 314 4 0 2 4.9 CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2014.01.055
CHEMBL3121416 113053 0 None -4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 314 4 0 2 4.9 CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2014.01.055
CHEMBL3139020 113053 0 None -4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 314 4 0 2 4.9 CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12 10.1016/j.ejmech.2014.01.055
44268087 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
CHEMBL13049 26966 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 374 6 0 3 4.0 CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 10.1021/jm030030n
76328898 113193 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.01.055
CHEMBL3121440 113193 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.01.055
CHEMBL3139518 113193 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.01.055
145983144 172659 0 None -5 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4249426 172659 0 None -5 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
134154387 159239 0 None 1 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 289 3 0 1 4.5 C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 10.1016/j.bmc.2016.09.019
CHEMBL3970994 159239 0 None 1 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 289 3 0 1 4.5 C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 10.1016/j.bmc.2016.09.019
56944863 163498 0 None -64 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4070254 163498 0 None -64 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.7b00839
155540635 179309 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 431 7 1 4 5.4 O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4483687 179309 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 431 7 1 4 5.4 O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
11431530 91400 0 None 1 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 405 8 1 3 4.6 O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL222188 91400 0 None 1 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 405 8 1 3 4.6 O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
168269921 196859 0 None -218 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 430 8 0 7 3.4 O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
CHEMBL5172673 196859 0 None -218 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay
ChEMBL 430 8 0 7 3.4 O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12 10.1016/j.ejmech.2022.114319
21527771 76931 1 None -263 10 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940404 76931 1 None -263 10 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
71602687 96459 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 376 5 0 3 4.8 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376456 96459 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 376 5 0 3 4.8 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2013.02.038
56850656 78273 0 None -27 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 2.6 O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926744 78273 0 None -27 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 2.6 O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962584 78273 0 None -27 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 7 1 4 2.6 O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
118626088 172180 0 None -13 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4238124 172180 0 None -13 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 508 6 0 7 3.4 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1 10.1016/j.ejmech.2018.01.002
134154387 159239 0 None 1 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 289 3 0 1 4.5 C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 10.1016/j.bmc.2016.09.019
CHEMBL3970994 159239 0 None 1 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 289 3 0 1 4.5 C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 10.1016/j.bmc.2016.09.019
72548349 120864 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326991 120864 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 471 10 1 4 5.3 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1 10.1016/j.bmc.2014.07.026
76284725 111790 0 None 14 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 462 10 1 6 3.7 O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
CHEMBL3113602 111790 0 None 14 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 462 10 1 6 3.7 O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
168295509 199293 0 None -5 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 449 6 1 8 3.0 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
CHEMBL5209283 199293 0 None -5 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis
ChEMBL 449 6 1 8 3.0 COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC 10.1016/j.ejmech.2022.114218
71602687 96459 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 376 5 0 3 4.8 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2013.02.038
CHEMBL2376456 96459 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 376 5 0 3 4.8 COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1 10.1016/j.bmc.2013.02.038
53323534 63797 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1 10.1016/j.bmcl.2010.11.078
CHEMBL1644485 63797 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1 10.1016/j.bmcl.2010.11.078
46205042 131355 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 309 5 1 3 3.9 Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1 nan
CHEMBL3640583 131355 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 309 5 1 3 3.9 Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1 nan
46205042 131355 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 309 5 1 3 3.9 Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1 nan
CHEMBL3640583 131355 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 309 5 1 3 3.9 Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1 nan
155515942 176788 0 None -331 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 389 3 1 5 3.8 O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21 10.1021/acsmedchemlett.6b00056
CHEMBL4442456 176788 0 None -331 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 389 3 1 5 3.8 O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21 10.1021/acsmedchemlett.6b00056
46233382 207462 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 271 6 0 3 3.3 COc1ccccc1-c1ccccc1OCCN(C)C 10.1016/j.bmc.2010.01.035
CHEMBL599819 207462 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 271 6 0 3 3.3 COc1ccccc1-c1ccccc1OCCN(C)C 10.1016/j.bmc.2010.01.035
46204425 131343 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 239 3 1 2 3.0 Cc1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640572 131343 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 239 3 1 2 3.0 Cc1ccccc1-c1cccc(OC2CNC2)c1 nan
46204425 131343 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 239 3 1 2 3.0 Cc1ccccc1-c1cccc(OC2CNC2)c1 nan
CHEMBL3640572 131343 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 239 3 1 2 3.0 Cc1ccccc1-c1cccc(OC2CNC2)c1 nan
122181335 128655 0 None -11 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 486 6 1 4 4.0 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590087 128655 0 None -11 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 486 6 1 4 4.0 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2015.04.026
145976408 170657 0 None 10 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 424 5 1 4 3.4 O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
CHEMBL4206881 170657 0 None 10 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
ChEMBL 424 5 1 4 3.4 O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2018.06.019
145964621 171116 0 None 18 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4212539 171116 0 None 18 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 516 7 1 4 4.0 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1 10.1021/acs.jmedchem.8b00828
134154680 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3959919 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3991166 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
156022234 184989 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 380 5 1 4 4.2 CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
CHEMBL4649697 184989 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 380 5 1 4 4.2 CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmc.2020.115578
181743 185351 5 None -33 22 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
CHEMBL467094 185351 5 None -33 22 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
56944086 118859 0 None -12 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 420 8 1 7 2.8 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3289976 118859 0 None -12 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 420 8 1 7 2.8 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
134154680 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3959919 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL3991166 161341 0 None -9 9 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 416 7 0 5 5.3 COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 10.1016/j.bmc.2016.09.019
CHEMBL5082267 221574 0 None -22 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00497
145984807 172555 0 None -134 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
CHEMBL4247275 172555 0 None -134 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 1 7 3.0 O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1 10.1016/j.ejmech.2018.01.002
122483230 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765223 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765836 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
10150497 10846 47 None -331 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 380 4 1 7 2.7 NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 10.1021/jm070521y
3240 10846 47 None -331 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 380 4 1 7 2.7 NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 10.1021/jm070521y
CHEMBL392760 10846 47 None -331 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 380 4 1 7 2.7 NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 10.1021/jm070521y
11494176 78294 0 None -1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926735 78294 0 None -1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962803 78294 0 None -1 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 357 7 1 4 2.2 O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1 10.1021/jm2007886
127041261 143776 0 None 4 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 448 7 0 4 4.3 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1 10.1016/j.bmc.2015.11.041
CHEMBL3745975 143776 0 None 4 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 448 7 0 4 4.3 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1 10.1016/j.bmc.2015.11.041
57391622 78342 0 None 11 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1949970 78342 0 None 11 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
CHEMBL1963100 78342 0 None 11 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 10.1016/j.bmc.2011.12.039
42625181 199946 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 403 7 1 4 3.4 O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1 10.1021/jm8014553
CHEMBL523121 199946 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 403 7 1 4 3.4 O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1 10.1021/jm8014553
118728513 124486 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 1 5 4.8 Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401476 124486 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 1 5 4.8 Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
44424660 92550 0 None -5 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 454 9 0 9 1.8 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL229311 92550 0 None -5 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 454 9 0 9 1.8 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
122483230 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765223 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765836 144866 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 350 9 0 3 5.7 CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
44374226 61328 1 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 188 4 0 4 1.8 CN(C)CCSc1nccs1 10.1016/j.bmcl.2003.11.050
CHEMBL161031 61328 1 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 188 4 0 4 1.8 CN(C)CCSc1nccs1 10.1016/j.bmcl.2003.11.050
11101259 58357 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 392 8 2 5 3.8 O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O 10.1021/jm020994z
CHEMBL158332 58357 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 392 8 2 5 3.8 O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O 10.1021/jm020994z
71452383 90571 0 None -3 3 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 339 5 1 4 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmcl.2012.08.046
CHEMBL2205814 90571 0 None -3 3 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor
ChEMBL 339 5 1 4 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC 10.1016/j.bmcl.2012.08.046
145983751 172284 0 None -13 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 521 6 0 7 4.6 O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4240642 172284 0 None -13 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 521 6 0 7 4.6 O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
66801537 164711 0 None -3 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 465 6 2 3 5.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4084492 164711 0 None -3 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 465 6 2 3 5.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
57400281 78327 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949965 78327 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963028 78327 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 458 8 1 5 3.8 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1 10.1016/j.bmc.2011.12.039
122178698 128143 0 None 1 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 369 5 0 5 3.9 CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
CHEMBL3581244 128143 0 None 1 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
ChEMBL 369 5 0 5 3.9 CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 10.1021/np500893h
42625183 193779 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 397 5 0 3 4.1 O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
CHEMBL490645 193779 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 397 5 0 3 4.1 O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
42625446 195637 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 413 7 0 3 4.7 O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
CHEMBL506875 195637 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 413 7 0 3 4.7 O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1 10.1021/jm8014553
24771120 190879 0 None -3019 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 434 4 2 6 3.4 O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1 10.1016/j.bmcl.2009.03.071
CHEMBL482562 190879 0 None -3019 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 434 4 2 6 3.4 O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1 10.1016/j.bmcl.2009.03.071
134150597 158844 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 339 4 0 4 4.3 COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3967387 158844 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 339 4 0 4 4.3 COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
118736372 125722 0 None -11 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 497 7 0 9 2.6 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2015.04.046
CHEMBL3423336 125722 0 None -11 4 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method
ChEMBL 497 7 0 9 2.6 Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2015.04.046
153061504 179589 0 None -34 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 241 1 1 2 3.4 CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
CHEMBL4513930 179589 0 None -34 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
ChEMBL 241 1 1 2 3.4 CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
155533028 178575 0 None -1 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 458 9 0 5 5.1 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4468036 178575 0 None -1 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 458 9 0 5 5.1 O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4520788 220754 10 None -32 25 Human 6.2 pKi = 6.2 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7
ChEMBL None None None CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 10.6019/CHEMBL5212743
10090247 212349 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 365 3 0 3 4.2 FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
CHEMBL81276 212349 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 365 3 0 3 4.2 FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1021/jm030030n
10090247 212349 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 365 3 0 3 4.2 FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL81276 212349 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 365 3 0 3 4.2 FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
127026753 144503 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 8 1 4 3.0 CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1 10.1016/j.ejmech.2015.11.040
CHEMBL3758978 144503 0 None 6 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 392 8 1 4 3.0 CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1 10.1016/j.ejmech.2015.11.040
127042185 143845 0 None 4 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 454 8 0 6 3.3 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1 10.1016/j.bmc.2015.11.041
CHEMBL3747003 143845 0 None 4 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 454 8 0 6 3.3 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1 10.1016/j.bmc.2015.11.041
145985533 172511 0 None -7 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4246202 172511 0 None -7 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
145983139 172643 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4249179 172643 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 491 6 0 7 3.7 O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
71449629 88149 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159321 88149 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 428 8 1 5 4.0 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1 10.1016/j.ejmech.2012.07.043
71455000 88198 0 None 8 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159466 88198 0 None 8 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
71449643 88213 0 None 3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 8 1 4 4.1 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159481 88213 0 None 3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 8 1 4 4.1 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
145947300 174442 0 None 19 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 511 6 2 6 2.3 CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4170613 174442 0 None 19 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 511 6 2 6 2.3 CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4301924 174442 0 None 19 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 511 6 2 6 2.3 CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
156011936 184181 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 435 8 1 6 4.3 O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4638308 184181 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 435 8 1 6 4.3 O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
156019026 184575 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 436 8 0 7 4.6 O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4643450 184575 0 None -1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 436 8 0 7 4.6 O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
60195996 88589 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 283 3 1 4 2.7 O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
CHEMBL2164338 88589 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 283 3 1 4 2.7 O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1 10.1021/jm3003679
71455000 88198 0 None 8 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1039/C5MD00166H
CHEMBL2159466 88198 0 None 8 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1039/C5MD00166H
127038033 143384 0 None 14 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 453 8 1 5 4.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1 10.1039/C5MD00166H
CHEMBL3739680 143384 0 None 14 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 453 8 1 5 4.2 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1 10.1039/C5MD00166H
127039756 143506 0 None 25 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F 10.1039/C5MD00166H
CHEMBL3740801 143506 0 None 25 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 472 8 1 4 4.5 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F 10.1039/C5MD00166H
127039753 143520 0 None 22 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 454 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1039/C5MD00166H
CHEMBL3740913 143520 0 None 22 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 454 8 1 4 4.3 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 10.1039/C5MD00166H
42625440 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1016/j.ejmech.2014.08.023
CHEMBL445334 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1016/j.ejmech.2014.08.023
25256855 196537 0 None 64 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL515939 196537 0 None 64 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.ejmech.2014.08.023
21048816 82275 0 None 30 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 385 7 0 3 4.9 CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
CHEMBL204269 82275 0 None 30 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 385 7 0 3 4.9 CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
11589069 103022 0 None 10 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
CHEMBL260994 103022 0 None 10 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm200547z
42625440 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm500880c
CHEMBL445334 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm500880c
42625440 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm8014553
CHEMBL445334 177592 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 10.1021/jm8014553
25256855 196537 0 None 64 3 Human 8.2 pKi = 8.2 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL515939 196537 0 None 64 3 Human 8.2 pKi = 8.2 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 398 7 1 4 4.0 O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2009.02.008
11145126 211180 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 470 5 1 4 4.9 CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL71959 211180 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 470 5 1 4 4.9 CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
60196077 88594 0 None 20 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 298 4 1 4 2.8 COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
CHEMBL2164343 88594 0 None 20 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 298 4 1 4 2.8 COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
132525569 170828 0 None 1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes
ChEMBL 272 3 0 5 2.1 CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 10.1021/acs.jmedchem.7b01898
CHEMBL4208934 170828 0 None 1 5 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes
ChEMBL 272 3 0 5 2.1 CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 10.1021/acs.jmedchem.7b01898
24768516 99361 0 None 11 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 433 9 1 3 5.1 CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL243523 99361 0 None 11 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 433 9 1 3 5.1 CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
44374207 59272 0 None 5 3 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 280 5 1 4 2.9 CN(C)CCSc1cccc(C2(O)CCCCC2)n1 10.1016/j.bmcl.2003.11.050
CHEMBL159143 59272 0 None 5 3 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 280 5 1 4 2.9 CN(C)CCSc1cccc(C2(O)CCCCC2)n1 10.1016/j.bmcl.2003.11.050
9911844 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/j.ejmech.2019.111705
CHEMBL348890 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/j.ejmech.2019.111705
9911844 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
CHEMBL348890 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
9911844 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
CHEMBL348890 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1016/s0960-894x(02)00842-9
162654006 187269 0 None -29 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 425 7 1 6 3.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 10.1016/j.ejmech.2020.112149
CHEMBL4753094 187269 0 None -29 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 425 7 1 6 3.6 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 10.1016/j.ejmech.2020.112149
162643812 188442 0 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 10.1016/j.ejmech.2020.112149
CHEMBL4776225 188442 0 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 435 7 1 5 4.0 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 10.1016/j.ejmech.2020.112149
9911844 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1021/jm070279v
CHEMBL348890 126648 1 None 43 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 454 6 1 2 6.5 O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3 10.1021/jm070279v
10873805 211473 2 None -2 5 Human 8.1 pKi = 8.1 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1 10.1021/jm0200411
CHEMBL73979 211473 2 None -2 5 Human 8.1 pKi = 8.1 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1 10.1021/jm0200411
5 6927 72 None -5 53 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2007.05.010
5202 6927 72 None -5 53 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2007.05.010
CHEMBL39 6927 72 None -5 53 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2007.05.010
DB08839 6927 72 None -5 53 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.bmc.2007.05.010
35985234 95121 15 None 194 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 211 3 1 1 3.2 Cc1ccccc1-c1cccc(CCN)c1 10.1016/j.bmcl.2007.03.054
CHEMBL234885 95121 15 None 194 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 211 3 1 1 3.2 Cc1ccccc1-c1cccc(CCN)c1 10.1016/j.bmcl.2007.03.054
145976433 170709 0 None 2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 372 6 0 3 4.7 COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1 10.1021/acs.jmedchem.7b01898
CHEMBL4207454 170709 0 None 2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 372 6 0 3 4.7 COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1 10.1021/acs.jmedchem.7b01898
155522867 177605 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 401 8 1 6 3.5 COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2019.111690
CHEMBL4453552 177605 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 401 8 1 6 3.5 COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2019.111690
118713686 121168 0 None -28 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 409 9 0 5 4.8 O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331389 121168 0 None -28 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 409 9 0 5 4.8 O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
168271960 196887 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 368 6 0 3 3.5 CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 10.1021/acs.jmedchem.2c00633
CHEMBL5173014 196887 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 368 6 0 3 3.5 CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 10.1021/acs.jmedchem.2c00633
11395034 78274 0 None -1 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 385 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926751 78274 0 None -1 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 385 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962585 78274 0 None -1 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 385 9 1 4 3.0 O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
16747715 157822 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 239 4 0 1 3.8 Cc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmc.2010.01.035
CHEMBL395870 157822 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
ChEMBL 239 4 0 1 3.8 Cc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmc.2010.01.035
16747715 157822 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 239 4 0 1 3.8 Cc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
CHEMBL395870 157822 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 239 4 0 1 3.8 Cc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
11515799 163718 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 348 6 1 2 4.5 CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21 10.1021/jm070279v
CHEMBL407263 163718 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 348 6 1 2 4.5 CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21 10.1021/jm070279v
136152971 102132 0 None -4 6 Human 8.1 pKi = 8.1 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
CHEMBL256694 102132 0 None -4 6 Human 8.1 pKi = 8.1 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 293 2 2 3 3.5 C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.078
118713687 121170 0 None -40 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 423 10 0 6 4.4 COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331390 121170 0 None -40 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 423 10 0 6 4.4 COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
164621627 192262 0 None -10 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 369 5 0 4 3.7 O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4862180 192262 0 None -10 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 369 5 0 4 3.7 O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
118713588 121150 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 397 7 0 6 3.7 COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331257 121150 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 397 7 0 6 3.7 COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
10429067 130408 0 None 43 5 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 367 8 0 3 5.4 CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
CHEMBL361875 130408 0 None 43 5 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 367 8 0 3 5.4 CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
10429067 130408 0 None 43 5 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor
ChEMBL 367 8 0 3 5.4 CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
CHEMBL361875 130408 0 None 43 5 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor
ChEMBL 367 8 0 3 5.4 CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1 10.1021/jm0498102
10257 7525 31 None -3 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 10.1021/jm030826m
144 7525 31 None -3 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 10.1021/jm030826m
CHEMBL416526 7525 31 None -3 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 10.1021/jm030826m
DB01445 7525 31 None -3 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 10.1021/jm030826m
10884517 109030 1 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 431 7 1 4 4.4 CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL303166 109030 1 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 431 7 1 4 4.4 CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
206 9271 16 None -6 25 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1016/s0960-894x(00)00166-9
68848 9271 16 None -6 25 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1016/s0960-894x(00)00166-9
CHEMBL12314 9271 16 None -6 25 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1016/s0960-894x(00)00166-9
11391654 187304 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4753511 187304 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
5 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2019.111705
5202 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2019.111705
CHEMBL39 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2019.111705
DB08839 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1016/j.ejmech.2019.111705
9954003 78475 24 None -15 9 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 422 5 2 4 3.8 C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O 10.1021/jm070516u
CHEMBL196514 78475 24 None -15 9 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 422 5 2 4 3.8 C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O 10.1021/jm070516u
197033 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
CHEMBL589390 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.bmcl.2009.11.037
206 9271 16 None -10 25 Human 8.1 pKi = 8.1 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm030841r
68848 9271 16 None -10 25 Human 8.1 pKi = 8.1 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm030841r
CHEMBL12314 9271 16 None -10 25 Human 8.1 pKi = 8.1 Binding
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
ChEMBL 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 10.1021/jm030841r
46205374 131366 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1 nan
CHEMBL3640594 131366 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1 nan
168268877 196749 0 None -1 12 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 328 2 3 3 3.8 COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 10.1021/acsmedchemlett.1c00694
CHEMBL5170784 196749 0 None -1 12 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant
ChEMBL 328 2 3 3 3.8 COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 10.1021/acsmedchemlett.1c00694
46205374 131366 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1 nan
CHEMBL3640594 131366 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 321 3 1 2 4.5 COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1 nan
100 10577 58 None -28 54 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1021/jm030030n
2637 10577 58 None -28 54 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1021/jm030030n
5452 10577 58 None -28 54 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1021/jm030030n
CHEMBL479 10577 58 None -28 54 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1021/jm030030n
DB00679 10577 58 None -28 54 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1021/jm030030n
44460917 111187 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 297 4 0 3 3.3 C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL310317 111187 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 297 4 0 3 3.3 C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1 10.1016/s0960-894x(02)00438-9
44460980 212719 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 3 0 3 3.6 Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL84270 212719 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 361 3 0 3 3.6 Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1 10.1016/s0960-894x(02)00438-9
76321737 113196 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3121428 113196 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
CHEMBL3139525 113196 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 397 5 0 4 5.0 COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.ejmech.2014.01.055
127026132 144624 0 None 6 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 432 8 1 6 2.9 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3760010 144624 0 None 6 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 432 8 1 6 2.9 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1 10.1016/j.ejmech.2015.11.040
127041260 143834 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 430 7 0 4 4.1 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2015.11.041
CHEMBL3746806 143834 0 None 5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 430 7 0 4 4.1 CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2015.11.041
90654838 119464 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 448 9 0 4 4.2 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233668 119464 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 448 9 0 4 4.2 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304237 119464 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 448 9 0 4 4.2 CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
155545625 180240 0 None 102 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 255 4 1 3 3.5 CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1 10.1016/j.ejmech.2019.03.017
CHEMBL4529615 180240 0 None 102 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 255 4 1 3 3.5 CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1 10.1016/j.ejmech.2019.03.017
56944864 164339 0 None -27 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 457 8 2 3 5.0 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4080369 164339 0 None -27 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 457 8 2 3 5.0 Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
135367816 171614 0 None 3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None 3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
145947937 174502 0 None -13 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4207653 174502 0 None -13 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4302655 174502 0 None -13 6 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 10.1016/j.bmcl.2018.04.059
11478226 143718 0 None 12 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
CHEMBL374297 143718 0 None 12 2 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 465 10 1 5 4.6 COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
57399494 77232 0 None -1 8 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 386 4 0 3 4.4 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115943
CHEMBL1946124 77232 0 None -1 8 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 386 4 0 3 4.4 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115943
135367816 171614 0 None 3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
CHEMBL4218801 171614 0 None 3 5 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 248 1 1 3 2.7 Clc1ccc(-c2noc3c2CCNCC3)cc1 10.1021/acs.jmedchem.8b00642
11430856 84796 32 None -134 3 Human 6.2 pKi = 6.2 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 450 10 2 5 3.0 CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1 10.1021/jm0508641
CHEMBL209821 84796 32 None -134 3 Human 6.2 pKi = 6.2 Binding
Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay
ChEMBL 450 10 2 5 3.0 CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1 10.1021/jm0508641
127035062 143229 0 None -23 19 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
CHEMBL3735756 143229 0 None -23 19 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
11261344 176087 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 476 9 1 6 4.7 COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1 10.1021/jm049702f
CHEMBL441560 176087 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 476 9 1 6 4.7 COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1 10.1021/jm049702f
135367858 170560 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4205846 170560 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
216239 30567 118 None -9 7 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1021/jm300338m
CHEMBL1200485 30567 118 None -9 7 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1021/jm300338m
CHEMBL1336 30567 118 None -9 7 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1021/jm300338m
155560943 183346 0 None -2344 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 382 4 2 6 3.2 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
CHEMBL4574931 183346 0 None -2344 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 382 4 2 6 3.2 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
CHEMBL4597364 183346 0 None -2344 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 382 4 2 6 3.2 COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1 10.1016/j.ejmech.2019.06.001
10698929 106130 0 None 3 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 607 5 0 7 5.6 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3 10.1021/jm0108505
CHEMBL282413 106130 0 None 3 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 607 5 0 7 5.6 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3 10.1021/jm0108505
71449628 88144 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 404 7 1 3 4.4 O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159317 88144 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 404 7 1 3 4.4 O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1 10.1016/j.ejmech.2012.07.043
122181251 128633 0 None -27 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 448 7 1 5 3.0 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3589977 128633 0 None -27 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 448 7 1 5 3.0 COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1 10.1016/j.bmc.2015.04.026
156022244 184000 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 241 2 0 2 3.4 CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1 10.1016/j.bmc.2019.115262
CHEMBL4635538 184000 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 241 2 0 2 3.4 CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1 10.1016/j.bmc.2019.115262
76280896 111789 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 462 10 1 6 3.7 O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
CHEMBL3113601 111789 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins
ChEMBL 462 10 1 6 3.7 O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1 10.1016/j.bmc.2014.01.016
25107583 199656 0 None -2 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 489 12 1 7 3.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
CHEMBL522194 199656 0 None -2 3 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 489 12 1 7 3.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
155533648 178664 0 None -5 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 486 9 0 6 4.7 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4469539 178664 0 None -5 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 486 9 0 6 4.7 O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1016/j.bmcl.2019.06.029
155564824 182309 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay
ChEMBL 412 4 3 6 3.9 C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b00689
CHEMBL4578381 182309 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay
ChEMBL 412 4 3 6 3.9 C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b00689
145954503 169198 0 None -7 2 Human 4.2 pKi = 4.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 370 5 1 4 4.1 O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1 10.1016/j.ejmech.2018.04.010
CHEMBL4166092 169198 0 None -7 2 Human 4.2 pKi = 4.2 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 370 5 1 4 4.1 O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1 10.1016/j.ejmech.2018.04.010
168288598 198552 0 None -177 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 400 10 3 9 1.8 COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
CHEMBL5197911 198552 0 None -177 5 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 400 10 3 9 1.8 COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
44278114 106981 0 None -104 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 334 5 1 3 3.8 CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
CHEMBL28833 106981 0 None -104 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor
ChEMBL 334 5 1 3 3.8 CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 10.1016/s0960-894x(01)00241-4
126720425 168893 0 None -354 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 369 4 1 5 3.7 CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1 10.1016/j.ejmech.2017.12.053
CHEMBL4161308 168893 0 None -354 5 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 369 4 1 5 3.7 CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1 10.1016/j.ejmech.2017.12.053
135367858 170560 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4205846 170560 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 231 1 2 2 1.9 Fc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
127027386 144441 0 None 5 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 403 8 1 5 3.0 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3758466 144441 0 None 5 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 403 8 1 5 3.0 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1 10.1016/j.ejmech.2015.11.040
156013612 184007 0 None -7 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 452 9 0 7 5.9 c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1 10.1016/j.bmc.2020.115459
CHEMBL4635603 184007 0 None -7 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 452 9 0 7 5.9 c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1 10.1016/j.bmc.2020.115459
90654840 119411 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233669 119411 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3302757 119411 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 478 10 0 5 4.2 COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1 10.1016/j.ejmech.2014.01.065
57399494 77232 0 None -1 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 386 4 0 3 4.4 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115943
CHEMBL1946124 77232 0 None -1 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 386 4 0 3 4.4 O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2020.115943
54758202 72783 0 None 9 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 497 7 1 3 6.4 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl 10.1021/jm200547z
CHEMBL1836858 72783 0 None 9 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 497 7 1 3 6.4 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl 10.1021/jm200547z
10895284 109886 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 430 7 1 3 5.0 CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
CHEMBL307686 109886 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 430 7 1 3 5.0 CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 10.1021/jm0104264
117209964 192913 1 None 3 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4871980 192913 1 None 3 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
52952308 69354 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 389 6 1 5 4.6 N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
CHEMBL1782793 69354 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 389 6 1 5 4.6 N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1 10.1021/jm2000773
90654680 116878 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 468 8 1 4 3.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235752 116878 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 468 8 1 4 3.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2014.03.005
46206022 131380 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 0 2 3.8 COc1ccccc1-c1ccccc1C1CCN(C)C1 nan
CHEMBL3640608 131380 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 267 3 0 2 3.8 COc1ccccc1-c1ccccc1C1CCN(C)C1 nan
46206022 131380 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 0 2 3.8 COc1ccccc1-c1ccccc1C1CCN(C)C1 nan
CHEMBL3640608 131380 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 267 3 0 2 3.8 COc1ccccc1-c1ccccc1C1CCN(C)C1 nan
155538451 179166 0 None -2 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 485 10 0 5 5.2 CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4476432 179166 0 None -2 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 485 10 0 5 5.2 CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.bmcl.2019.06.029
117209964 192913 1 None 3 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4871980 192913 1 None 3 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
156019279 184752 0 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 338 3 0 4 3.5 COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4645997 184752 0 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 338 3 0 4 3.5 COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
134157289 160860 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
CHEMBL3984812 160860 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl 10.1016/j.ejmech.2016.07.029
44455943 175781 5 None -2 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 243 1 2 3 3.0 CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.080
CHEMBL439240 175781 5 None -2 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 243 1 2 3 3.0 CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.080
118724637 127392 0 None -4 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3360997 127392 0 None -4 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
CHEMBL3546115 127392 0 None -4 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
ChEMBL 464 6 0 8 2.3 Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O 10.1016/j.bmc.2014.11.008
44582705 193775 0 None -4 13 Human 6.1 pKi = 6.1 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 399 9 0 4 4.5 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL490632 193775 0 None -4 13 Human 6.1 pKi = 6.1 Binding
Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment
ChEMBL 399 9 0 4 4.5 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 10.1016/j.bmc.2009.03.021
155563374 182025 0 None -831 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 423 3 1 5 4.5 O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21 10.1021/acsmedchemlett.6b00056
CHEMBL4572158 182025 0 None -831 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 423 3 1 5 4.5 O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21 10.1021/acsmedchemlett.6b00056
53376041 73145 0 None -11 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL1851658 73145 0 None -11 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2011.04.060
CHEMBL3215835 73145 0 None -11 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay
ChEMBL 431 6 0 6 3.7 O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1 10.1016/j.ejmech.2011.04.060
134133064 151513 0 None 4 6 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 314 5 0 3 3.0 CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1 10.1016/j.bmc.2016.09.019
CHEMBL3908870 151513 0 None 4 6 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 314 5 0 3 3.0 CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1 10.1016/j.bmc.2016.09.019
122483223 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764650 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765874 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
56850387 78253 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 365 8 1 3 3.2 O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 10.1021/jm2007886
CHEMBL1926731 78253 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 365 8 1 3 3.2 O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 10.1021/jm2007886
CHEMBL1962455 78253 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 365 8 1 3 3.2 O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 10.1021/jm2007886
127026071 144538 0 None 25 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 7 1 4 4.5 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2015.11.040
CHEMBL3759298 144538 0 None 25 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 7 1 4 4.5 CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2015.11.040
145963860 171005 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 8 1 4 4.2 CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
CHEMBL4211091 171005 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis
ChEMBL 434 8 1 4 4.2 CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 10.1016/j.bmc.2017.03.057
155525703 177832 0 None -6 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 452 8 1 8 1.6 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4456962 177832 0 None -6 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 452 8 1 8 1.6 COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
10950559 210744 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 457 6 1 3 5.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3 10.1016/j.bmc.2019.06.028
CHEMBL69388 210744 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method
ChEMBL 457 6 1 3 5.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3 10.1016/j.bmc.2019.06.028
122483223 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764650 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765874 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
42626293 157904 0 None 1 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 349 6 0 3 3.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
CHEMBL395933 157904 0 None 1 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 349 6 0 3 3.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
11200511 208509 0 None -74 8 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 10.1021/jm049243i
CHEMBL606547 208509 0 None -74 8 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 10.1021/jm049243i
127036932 144126 0 None -2 22 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3752900 144126 0 None -2 22 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
10950559 210744 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 457 6 1 3 5.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3 10.1021/jm0104264
CHEMBL69388 210744 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 457 6 1 3 5.2 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3 10.1021/jm0104264
122483223 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3764650 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
CHEMBL3765874 144887 0 None 5 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 455 8 0 5 5.8 COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 10.1016/j.ejmech.2016.01.043
162662367 188823 0 None 18 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 531 10 0 5 7.7 COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
CHEMBL4781056 188823 0 None 18 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
ChEMBL 531 10 0 5 7.7 COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1 10.1016/j.ejmech.2020.112395
156015306 184393 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
CHEMBL4640899 184393 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 269 2 0 1 3.9 CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
156020091 184967 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 325 6 0 1 5.5 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
CHEMBL4649327 184967 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 325 6 0 1 5.5 CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1 10.1016/j.bmc.2019.115262
145977338 170496 0 None -74 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 259 3 2 4 2.2 Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1 10.1021/acs.jnatprod.7b00317
CHEMBL4205064 170496 0 None -74 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
ChEMBL 259 3 2 4 2.2 Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1 10.1021/acs.jnatprod.7b00317
156021059 184916 0 None -147 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 436 8 0 8 3.5 O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12 10.1016/j.bmc.2020.115459
CHEMBL4648581 184916 0 None -147 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 436 8 0 8 3.5 O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12 10.1016/j.bmc.2020.115459
11257767 73805 9 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 389 7 1 5 2.1 COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm049743b
CHEMBL187088 73805 9 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 389 7 1 5 2.1 COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1 10.1021/jm049743b
11325873 132573 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 360 7 1 4 2.4 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2 10.1021/jm049743b
CHEMBL364795 132573 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
ChEMBL 360 7 1 4 2.4 COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2 10.1021/jm049743b
118626042 172349 0 None -9 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4242170 172349 0 None -9 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 489 6 1 5 4.1 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1 10.1016/j.ejmech.2018.01.002
162666794 190511 0 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4784726 190511 0 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803549 190511 0 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 423 8 1 4 4.9 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
155556806 181309 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 381 7 1 4 4.3 O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
CHEMBL4555702 181309 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 381 7 1 4 4.3 O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12 10.1016/j.ejmech.2019.111690
164628817 193056 0 None -14 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 349 6 0 4 3.4 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 10.1016/j.ejmech.2021.113243
CHEMBL4874069 193056 0 None -14 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 349 6 0 4 3.4 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 10.1016/j.ejmech.2021.113243
44391622 72766 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 333 3 0 3 4.4 COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12 10.1016/j.bmcl.2004.11.013
CHEMBL183676 72766 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
ChEMBL 333 3 0 3 4.4 COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12 10.1016/j.bmcl.2004.11.013
46204424 131342 7 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 239 3 1 2 3.0 Cc1cccc(-c2cccc(OC3CNC3)c2)c1 nan
CHEMBL3640571 131342 7 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 239 3 1 2 3.0 Cc1cccc(-c2cccc(OC3CNC3)c2)c1 nan
46204424 131342 7 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 239 3 1 2 3.0 Cc1cccc(-c2cccc(OC3CNC3)c2)c1 nan
CHEMBL3640571 131342 7 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 239 3 1 2 3.0 Cc1cccc(-c2cccc(OC3CNC3)c2)c1 nan
156020902 184808 0 None -2 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 378 5 0 4 4.3 COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4646861 184808 0 None -2 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 378 5 0 4 4.3 COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
53320866 63798 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1 10.1016/j.bmcl.2010.11.078
CHEMBL1644486 63798 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins
ChEMBL 322 3 1 2 4.5 Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1 10.1016/j.bmcl.2010.11.078
10383646 25534 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 356 3 1 5 2.1 CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1 10.1021/jm1007825
CHEMBL1277917 25534 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells
ChEMBL 356 3 1 5 2.1 CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1 10.1021/jm1007825
46205043 131356 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 309 6 1 3 3.8 Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1 nan
CHEMBL3640584 131356 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 309 6 1 3 3.8 Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1 nan
46205043 131356 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 309 6 1 3 3.8 Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1 nan
CHEMBL3640584 131356 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 309 6 1 3 3.8 Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1 nan
127051843 147529 0 None -33 9 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 0 3 3.6 N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818200 147529 0 None -33 9 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 0 3 3.6 N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
127051843 147529 0 None -33 9 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 0 3 3.6 N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
CHEMBL3818200 147529 0 None -33 9 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 304 5 0 3 3.6 N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 10.1016/j.bmc.2016.05.053
46204084 131331 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1 nan
CHEMBL3640560 131331 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1 nan
46204084 131331 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1 nan
CHEMBL3640560 131331 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 269 4 1 3 3.0 COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1 nan
134135516 150951 0 None 7 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 469 10 1 6 3.5 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3904094 150951 0 None 7 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 469 10 1 6 3.5 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
25107582 194363 0 None -9 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 501 12 1 6 4.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
CHEMBL494661 194363 0 None -9 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 501 12 1 6 4.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 10.1021/jm800615e
122196373 131065 0 None -34 5 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 471 7 0 6 6.4 Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1 10.1016/j.bmcl.2015.09.045
CHEMBL3634813 131065 0 None -34 5 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
ChEMBL 471 7 0 6 6.4 Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1 10.1016/j.bmcl.2015.09.045
122181342 128662 0 None -25 2 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 494 7 1 4 4.9 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3590094 128662 0 None -25 2 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 494 7 1 4 4.9 O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2015.04.026
118731354 124968 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 10 0 4 4.9 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409037 124968 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 496 10 0 4 4.9 CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 10.1016/j.ejmech.2014.12.041
57392825 75172 0 None -5 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 496 9 0 4 4.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL1916744 75172 0 None -5 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 496 9 0 4 4.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3233402 75172 0 None -5 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 496 9 0 4 4.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
71602739 96465 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376462 96465 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2013.02.038
164628817 193056 0 None -14 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 349 6 0 4 3.4 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 10.1016/j.ejmech.2021.113243
CHEMBL4874069 193056 0 None -14 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 349 6 0 4 3.4 O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 10.1016/j.ejmech.2021.113243
56649649 74632 0 None -91 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 480 8 0 5 4.6 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910140 74632 0 None -91 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 480 8 0 5 4.6 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
59511191 192302 3 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4862745 192302 3 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
90656689 117763 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 7 1 5 3.1 COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262419 117763 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 353 7 1 5 3.1 COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
46204085 131332 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1 nan
CHEMBL3640561 131332 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1 nan
46204085 131332 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1 nan
CHEMBL3640561 131332 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 287 4 1 3 3.2 COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1 nan
134148917 155202 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 285 4 0 4 3.2 COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
CHEMBL3937741 155202 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 285 4 0 4 3.2 COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2 10.1016/j.ejmech.2016.07.029
35391328 75186 1 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 316 5 1 3 2.0 O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917332 75186 1 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 316 5 1 3 2.0 O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
155535879 183448 0 None -194 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1 10.1016/j.ejmech.2019.06.001
CHEMBL4472629 183448 0 None -194 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1 10.1016/j.ejmech.2019.06.001
CHEMBL4598209 183448 0 None -194 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1 10.1016/j.ejmech.2019.06.001
127052488 147577 0 None -23 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 477 8 0 4 6.3 Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.bmc.2016.06.011
CHEMBL3818799 147577 0 None -23 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 477 8 0 4 6.3 Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.bmc.2016.06.011
90654672 116870 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 480 9 1 5 3.5 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235744 116870 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 480 9 1 5 3.5 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.03.005
42428409 75185 6 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 366 5 1 3 3.2 O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917331 75185 6 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 366 5 1 3 3.2 O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
71451455 88193 0 None -4 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 9 1 5 4.1 CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2159461 88193 0 None -4 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 454 9 1 5 4.1 CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2012.07.043
90654672 116870 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 9 1 5 3.5 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
CHEMBL3235744 116870 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 480 9 1 5 3.5 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 10.1016/j.ejmech.2014.12.041
90654856 119470 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233677 119470 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3304304 119470 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 584 9 0 4 6.8 CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.ejmech.2014.01.065
59511191 192302 3 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
CHEMBL4862745 192302 3 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 228 2 2 3 1.5 c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 10.1021/acs.jmedchem.1c01093
164621627 192262 0 None -10 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 369 5 0 4 3.7 O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
CHEMBL4862180 192262 0 None -10 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 369 5 0 4 3.7 O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 10.1016/j.ejmech.2021.113243
42618266 197858 0 None -6 2 Human 7.1 pKi = 7.1 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 408 9 1 5 3.7 COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
CHEMBL518752 197858 0 None -6 2 Human 7.1 pKi = 7.1 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 408 9 1 5 3.7 COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2009.02.008
11266074 73040 1 None - 1 Rat 7.1 pKi = 7.1 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 283 3 1 3 3.2 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2 10.1021/jm0498102
CHEMBL184666 73040 1 None - 1 Rat 7.1 pKi = 7.1 Binding
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 283 3 1 3 3.2 COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2 10.1021/jm0498102
75201901 173204 19 None -575 24 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4277264 173204 19 None -575 24 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.9b00351
44439389 98555 0 None 8 2 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 324 3 1 5 2.8 COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C 10.1016/j.bmcl.2007.01.093
CHEMBL241099 98555 0 None 8 2 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 324 3 1 5 2.8 COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C 10.1016/j.bmcl.2007.01.093
146680920 178653 0 None -2570 6 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12 10.1021/acsmedchemlett.6b00056
CHEMBL4469309 178653 0 None -2570 6 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting
ChEMBL 419 4 1 6 3.8 COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12 10.1021/acsmedchemlett.6b00056
168269719 196790 0 None -2 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 444 7 3 8 2.9 COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2021.113931
CHEMBL5171456 196790 0 None -2 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 444 7 3 8 2.9 COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1 10.1016/j.ejmech.2021.113931
127029652 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3771222 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
57399089 75195 0 None -21 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1 10.1016/j.bmc.2011.09.044
CHEMBL1917341 75195 0 None -21 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 454 9 1 6 3.1 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1 10.1016/j.bmc.2011.09.044
127029652 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.bmcl.2018.02.003
127029652 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL3771222 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.bmcl.2018.02.003
CHEMBL3771222 145106 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)
ChEMBL 516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
134154531 159507 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
CHEMBL3973160 159507 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
ChEMBL 418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC 10.1016/j.ejmech.2016.07.029
9843889 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/s0960-894x(00)00166-9
CHEMBL12259 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/s0960-894x(00)00166-9
49850874 63236 0 None -251 9 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 450 6 1 4 5.2 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1632210 63236 0 None -251 9 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 450 6 1 4 5.2 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1 10.1021/jm100714c
11397149 63249 0 None -251 7 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 465 6 2 4 5.6 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1 10.1021/jm100714c
CHEMBL1632223 63249 0 None -251 7 Human 7.1 pKi = 7.1 Binding
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
ChEMBL 465 6 2 4 5.6 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1 10.1021/jm100714c
75306277 116031 0 None -39 23 Human 7.1 pKi = 7.1 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
CHEMBL3217984 116031 0 None -39 23 Human 7.1 pKi = 7.1 Binding
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
281 10283 28 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
5312148 10283 28 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
CHEMBL12264 10283 28 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 10.1021/jm030841r
9843889 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
CHEMBL12259 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm030841r
71602739 96465 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2013.02.038
CHEMBL2376462 96465 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
ChEMBL 388 6 0 4 4.7 COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmc.2013.02.038
117209911 193108 1 None 5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4874854 193108 1 None 5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
6540428 191643 1 None -19 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/j.ejmech.2019.111705
CHEMBL3989558 191643 1 None -19 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/j.ejmech.2019.111705
CHEMBL485253 191643 1 None -19 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
ChEMBL 353 4 2 4 1.9 CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 10.1016/j.ejmech.2019.111705
9804612 97310 0 None -19 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL238730 97310 0 None -19 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 467 6 1 5 4.5 Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 10.1016/j.bmcl.2006.11.031
44439167 97332 0 None -7 10 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
CHEMBL238732 97332 0 None -7 10 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells
ChEMBL 483 6 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 10.1016/j.bmcl.2006.11.031
135398745 9688 112 None -95 65 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm070516u
47 9688 112 None -95 65 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm070516u
CHEMBL715 9688 112 None -95 65 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm070516u
DB00334 9688 112 None -95 65 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1021/jm070516u
76518515 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3818881 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819714 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
60167166 82070 0 None -25 8 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 371 5 0 4 4.7 Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
CHEMBL2037430 82070 0 None -25 8 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 371 5 0 4 4.7 Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.ejmech.2012.03.042
44395796 73736 0 None -5 2 Rat 6.1 pKi = 6.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 343 6 0 5 1.5 COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL186734 73736 0 None -5 2 Rat 6.1 pKi = 6.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 343 6 0 5 1.5 COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
164613297 191396 0 None -19 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
CHEMBL4849230 191396 0 None -19 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
13702393 161804 2 None -7 6 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 181 0 2 3 1.4 NC1=Nc2cccc(Cl)c2CN1 10.1016/j.bmcl.2007.10.080
CHEMBL401541 161804 2 None -7 6 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 181 0 2 3 1.4 NC1=Nc2cccc(Cl)c2CN1 10.1016/j.bmcl.2007.10.080
CHEMBL556983 161804 2 None -7 6 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 181 0 2 3 1.4 NC1=Nc2cccc(Cl)c2CN1 10.1016/j.bmcl.2007.10.080
122483249 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764970 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765842 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
127052488 147577 0 None -23 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 477 8 0 4 6.3 Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.bmc.2016.06.011
CHEMBL3818799 147577 0 None -23 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 477 8 0 4 6.3 Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 10.1016/j.bmc.2016.06.011
168287126 198344 0 None 4 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 414 6 3 7 2.9 Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5194826 198344 0 None 4 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 414 6 3 7 2.9 Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
162671691 190540 0 None -6 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 481 10 1 6 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4792268 190540 0 None -6 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 481 10 1 6 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803838 190540 0 None -6 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 481 10 1 6 5.0 COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
136118730 83019 0 None -1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 318 1 3 2 2.3 CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12 10.1016/j.bmc.2013.09.011
CHEMBL2058407 83019 0 None -1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells
ChEMBL 318 1 3 2 2.3 CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12 10.1016/j.bmc.2013.09.011
162647425 186356 1 None -208 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis
ChEMBL 584 13 0 7 5.3 C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2020.112765
CHEMBL4741978 186356 1 None -208 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis
ChEMBL 584 13 0 7 5.3 C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1 10.1016/j.ejmech.2020.112765
10154897 72037 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 350 8 3 7 3.1 CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
CHEMBL182797 72037 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 350 8 3 7 3.1 CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1 10.1016/j.bmcl.2004.06.008
44393075 72501 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 7 3 6 3.4 CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL183462 72501 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 352 7 3 6 3.4 CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
197033 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.bmcl.2021.128275
CHEMBL589390 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.bmcl.2021.128275
197033 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.ejmech.2009.10.035
CHEMBL589390 205931 64 None 3 8 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay
ChEMBL 319 3 0 3 3.9 Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 10.1016/j.ejmech.2009.10.035
11199511 82208 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 369 6 0 3 4.2 O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1 10.1016/j.bmcl.2009.06.038
CHEMBL204171 82208 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 369 6 0 3 4.2 O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1 10.1016/j.bmcl.2009.06.038
56850385 78252 0 None 6 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 351 7 1 3 3.1 O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 10.1021/jm2007886
CHEMBL1926730 78252 0 None 6 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 351 7 1 3 3.1 O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 10.1021/jm2007886
CHEMBL1962454 78252 0 None 6 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 351 7 1 3 3.1 O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 10.1021/jm2007886
44408833 81227 0 None 112 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 363 6 0 3 4.5 CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL202780 81227 0 None 112 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 363 6 0 3 4.5 CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmc.2011.09.044
168282454 197994 0 None 3 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 485 11 4 8 3.6 Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
CHEMBL5189648 197994 0 None 3 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 485 11 4 8 3.6 Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1 10.1016/j.ejmech.2021.113931
168292411 198669 0 None 8 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 457 9 4 8 2.8 Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5199820 198669 0 None 8 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 457 9 4 8 2.8 Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
145984065 172530 0 None 1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4246630 172530 0 None 1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
134141166 153535 0 None 15 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 496 11 1 5 5.2 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3924375 153535 0 None 15 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 496 11 1 5 5.2 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
145946956 174374 0 None 12 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 532 8 2 5 3.9 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4166804 174374 0 None 12 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 532 8 2 5 3.9 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4300883 174374 0 None 12 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 532 8 2 5 3.9 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1016/j.ejmech.2018.01.093
155551353 180741 0 None 51 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 323 1 1 2 3.2 Cn1cncc1-c1c[nH]c2ccc(I)cc12 10.1016/j.ejmech.2019.03.017
CHEMBL4541526 180741 0 None 51 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method
ChEMBL 323 1 1 2 3.2 Cn1cncc1-c1c[nH]c2ccc(I)cc12 10.1016/j.ejmech.2019.03.017
127041108 143373 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 487 8 1 5 4.7 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12 10.1039/C5MD00166H
CHEMBL3739582 143373 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 487 8 1 5 4.7 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12 10.1039/C5MD00166H
127037679 143453 0 None 18 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 438 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1 10.1039/C5MD00166H
CHEMBL3740235 143453 0 None 18 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 438 8 1 4 3.9 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1 10.1039/C5MD00166H
127040760 143669 0 None 22 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 436 8 1 4 4.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1039/C5MD00166H
CHEMBL3742251 143669 0 None 22 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 436 8 1 4 4.3 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1 10.1039/C5MD00166H
11391654 187304 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4753511 187304 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
44408833 81227 0 None 112 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 363 6 0 3 4.5 CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
CHEMBL202780 81227 0 None 112 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 363 6 0 3 4.5 CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2005.11.067
11199511 82208 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 369 6 0 3 4.2 O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL204171 82208 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 369 6 0 3 4.2 O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1 10.1016/j.bmcl.2005.11.067
90656693 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262432 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304130 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
90656693 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262432 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3304130 119457 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 431 8 1 4 4.9 CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
5 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
5202 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
CHEMBL39 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
DB08839 6927 72 None -3 53 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm030030n
10949445 171784 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 402 6 2 3 4.9 O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0104264
CHEMBL422587 171784 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 402 6 2 3 4.9 O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 10.1021/jm0104264
46203757 131325 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1 nan
CHEMBL3640555 131325 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1 nan
46203757 131325 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1 nan
CHEMBL3640555 131325 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 283 4 1 3 3.3 COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1 nan
60196078 88580 2 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccccc1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
CHEMBL2164328 88580 2 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 268 3 1 3 2.8 COc1ccccc1-c1cccc(N2CCNCC2)c1 10.1021/jm3003679
16006606 164440 3 None -1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 191 1 2 4 1.3 COc1cccc2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
CHEMBL408152 164440 3 None -1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 191 1 2 4 1.3 COc1cccc2c1N=C(N)NC2C 10.1016/j.bmcl.2007.10.080
24854040 168024 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm070279v
CHEMBL411919 168024 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 445 7 1 3 5.6 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21 10.1021/jm070279v
25107647 194263 0 None 11 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 453 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1 10.1021/jm800615e
CHEMBL494118 194263 0 None 11 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 453 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1 10.1021/jm800615e
44319435 212893 0 None - 1 Human 8.1 pKi = 8.1 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 346 4 1 2 4.1 O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL85814 212893 0 None - 1 Human 8.1 pKi = 8.1 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 346 4 1 2 4.1 O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3 10.1016/s0960-894x(02)00485-7
164609529 191243 0 None -11 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
CHEMBL4846823 191243 0 None -11 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
24964217 93989 0 None 63 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 255 5 0 2 3.5 COc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
CHEMBL232792 93989 0 None 63 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 255 5 0 2 3.5 COc1ccccc1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
132547279 148979 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 434 9 0 6 4.1 CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884095 148979 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 434 9 0 6 4.1 CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1 10.1016/j.bmc.2016.12.039
118713688 121171 0 None -40 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 439 10 0 6 4.8 COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL3331391 121171 0 None -40 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 439 10 0 6 4.8 COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL5093342 222343 0 None 4 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095971 222343 0 None 4 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
164609529 191243 0 None -11 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
CHEMBL4846823 191243 0 None -11 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 383 5 0 4 4.1 CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O 10.1016/j.ejmech.2021.113243
10404657 104845 0 None 26 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 334 5 0 3 3.1 O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2016.05.053
CHEMBL273241 104845 0 None 26 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 334 5 0 3 3.1 O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2016.05.053
24963860 93988 0 None 562 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 285 6 0 3 3.5 COc1cccc(OC)c1-c1cccc(CCN(C)C)c1 10.1016/j.ejmech.2019.111705
CHEMBL232791 93988 0 None 562 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
ChEMBL 285 6 0 3 3.5 COc1cccc(OC)c1-c1cccc(CCN(C)C)c1 10.1016/j.ejmech.2019.111705
10404657 104845 0 None 26 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 334 5 0 3 3.1 O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2016.05.053
CHEMBL273241 104845 0 None 26 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 334 5 0 3 3.1 O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2016.05.053
24963860 93988 0 None 562 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 285 6 0 3 3.5 COc1cccc(OC)c1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
CHEMBL232791 93988 0 None 562 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells
ChEMBL 285 6 0 3 3.5 COc1cccc(OC)c1-c1cccc(CCN(C)C)c1 10.1016/j.bmcl.2007.03.054
25107580 194292 0 None 2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 432 10 1 4 4.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
CHEMBL494312 194292 0 None 2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 432 10 1 4 4.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
72550642 120855 0 None 2 8 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
CHEMBL3326982 120855 0 None 2 8 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 491 10 1 4 5.6 COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 10.1016/j.bmc.2014.07.026
CHEMBL5093342 222343 0 None 4 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
CHEMBL5095971 222343 0 None 4 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
76325353 113197 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 411 5 0 4 5.3 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3121438 113197 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 411 5 0 4 5.3 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
CHEMBL3139528 113197 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 411 5 0 4 5.3 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1 10.1016/j.ejmech.2014.01.055
16093484 104836 6 None -4 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 229 0 2 3 2.6 CC1NC(N)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.080
CHEMBL273170 104836 6 None -4 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 229 0 2 3 2.6 CC1NC(N)=Nc2ccc(Cl)c(Cl)c21 10.1016/j.bmcl.2007.10.080
10939416 210994 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 456 7 2 4 3.9 NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
CHEMBL70889 210994 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 456 7 2 4 3.9 NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 10.1021/jm0104264
11729823 109748 1 None -16 5 Human 8.1 pKi = 8.1 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1 10.1021/jm0200411
CHEMBL306478 109748 1 None -16 5 Human 8.1 pKi = 8.1 Binding
Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD
ChEMBL 437 5 0 2 4.6 O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1 10.1021/jm0200411
66801028 118880 0 None -2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 501 8 1 6 4.4 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
CHEMBL3289997 118880 0 None -2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 501 8 1 6 4.4 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 10.1021/jm401895u
6603866 104204 17 None -39 9 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm9911433
CHEMBL26998 104204 17 None -39 9 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm9911433
CHEMBL541268 104204 17 None -39 9 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 247 5 1 2 3.4 CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1 10.1021/jm9911433
46204427 131344 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 293 3 1 2 4.0 Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
CHEMBL3640573 131344 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 293 3 1 2 4.0 Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
46204427 131344 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 293 3 1 2 4.0 Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
CHEMBL3640573 131344 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 293 3 1 2 4.0 Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1 nan
44327952 214823 0 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 367 5 3 3 2.6 CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 10.1021/jm030030n
CHEMBL97518 214823 0 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 367 5 3 3 2.6 CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 10.1021/jm030030n
21091965 75187 9 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 380 6 1 3 3.6 O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917333 75187 9 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 380 6 1 3 3.6 O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1 10.1016/j.bmc.2011.09.044
60196075 88592 0 None -5 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 239 2 1 3 2.2 c1ccc(-c2cccc(N3CCNCC3)c2)nc1 10.1021/jm3003679
CHEMBL2164341 88592 0 None -5 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 239 2 1 3 2.2 c1ccc(-c2cccc(N3CCNCC3)c2)nc1 10.1021/jm3003679
66801528 163622 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
CHEMBL4071451 163622 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 449 6 2 3 4.5 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1021/acs.jmedchem.7b00839
66801052 165737 0 None -18 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 461 8 2 3 4.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4095979 165737 0 None -18 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 461 8 2 3 4.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
3084440 166594 7 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 327 2 2 5 2.9 COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmcl.2007.01.093
CHEMBL410604 166594 7 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 327 2 2 5 2.9 COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3 10.1016/j.bmcl.2007.01.093
76518515 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3818881 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
CHEMBL3819714 147648 0 None -4 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 454 7 1 5 5.8 O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 10.1016/j.bmc.2016.06.011
44401041 77262 0 None -18 7 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 313 2 0 3 4.1 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL194659 77262 0 None -18 7 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 313 2 0 3 4.1 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 10.1021/jm049632c
46205698 131371 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1cccc(-c2ccccc2C2CCNC2)c1 nan
CHEMBL3640599 131371 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
ChEMBL 237 2 1 1 3.7 Cc1cccc(-c2ccccc2C2CCNC2)c1 nan
46205698 131371 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1cccc(-c2ccccc2C2CCNC2)c1 nan
CHEMBL3640599 131371 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
ChEMBL 237 2 1 1 3.7 Cc1cccc(-c2ccccc2C2CCNC2)c1 nan
155526014 177843 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 422 7 0 5 2.9 CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2016.06.080
CHEMBL4457095 177843 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
ChEMBL 422 7 0 5 2.9 CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2016.06.080
44439387 98492 0 None 38 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 276 2 1 2 3.6 COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
CHEMBL240888 98492 0 None 38 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 276 2 1 2 3.6 COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1 10.1016/j.bmcl.2007.01.093
11773414 154063 0 None -2 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 380 4 1 4 4.2 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2 10.1016/j.bmcl.2007.01.093
CHEMBL392887 154063 0 None -2 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 380 4 1 4 4.2 COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2 10.1016/j.bmcl.2007.01.093
1984087 169076 10 None -2 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 9 1 3 5.3 COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1 10.1016/j.ejmech.2018.04.010
CHEMBL4164250 169076 10 None -2 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 351 9 1 3 5.3 COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1 10.1016/j.ejmech.2018.04.010
135 9310 43 None -83 56 Human 5.1 pKi = 5.1 Binding
Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
1796 9310 43 None -83 56 Human 5.1 pKi = 5.1 Binding
Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
4184 9310 43 None -83 56 Human 5.1 pKi = 5.1 Binding
Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
CHEMBL6437 9310 43 None -83 56 Human 5.1 pKi = 5.1 Binding
Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
DB06148 9310 43 None -83 56 Human 5.1 pKi = 5.1 Binding
Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1021/jm030030n
24768526 100006 0 None -41 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 422 8 1 4 3.2 O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21 10.1021/jm070487n
CHEMBL244792 100006 0 None -41 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 422 8 1 4 3.2 O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21 10.1021/jm070487n
117209911 193108 1 None 5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
CHEMBL4874854 193108 1 None 5 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting
ChEMBL 246 2 2 3 1.6 Fc1ccccc1-c1n[nH]cc1N1CCNCC1 10.1021/acs.jmedchem.1c01093
9992778 23031 0 None -2 3 Rat 7.1 pKi = 7.1 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 260 0 0 2 3.5 CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
CHEMBL122453 23031 0 None -2 3 Rat 7.1 pKi = 7.1 Binding
In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand
ChEMBL 260 0 0 2 3.5 CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5 10.1016/s0960-894x(00)00655-7
90656673 117748 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 308 2 1 3 3.1 Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2 10.1016/j.ejmech.2014.04.034
CHEMBL3262398 117748 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 308 2 1 3 3.1 Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2 10.1016/j.ejmech.2014.04.034
130442480 182049 0 None -100 24 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 410 3 0 6 5.7 Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F 10.1021/acs.jmedchem.9b00351
CHEMBL4572614 182049 0 None -100 24 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 410 3 0 6 5.7 Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F 10.1021/acs.jmedchem.9b00351
18377415 212901 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 2 3 3.2 O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3 10.1016/s0960-894x(02)00485-7
CHEMBL85897 212901 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 350 5 2 3 3.2 O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3 10.1016/s0960-894x(02)00485-7
71453156 87945 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 6 1 3 5.3 Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2012.07.043
CHEMBL2158036 87945 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 422 6 1 3 5.3 Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2012.07.043
24768521 99787 0 None -19 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 420 8 2 4 4.1 Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
CHEMBL244162 99787 0 None -19 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 420 8 2 4 4.1 Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm070487n
11178340 91470 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 446 8 1 5 4.7 O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
CHEMBL222604 91470 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 446 8 1 5 4.7 O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21 10.1021/jm049702f
155520499 177263 0 None -3 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 494 9 0 6 4.6 O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4449148 177263 0 None -3 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 494 9 0 6 4.6 O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 10.1016/j.bmcl.2019.06.029
145986720 174022 0 None 1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 436 7 2 5 2.1 CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4292541 174022 0 None 1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 436 7 2 5 2.1 CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O 10.1039/C8MD00168E
CHEMBL4777443 220825 0 None -39 14 Human 6.1 pKi = 6.1 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7
ChEMBL None None None CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1 10.6019/CHEMBL5212743
58405078 117473 0 None 2 4 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 310 5 1 5 3.0 Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1 10.1021/ml500082j
CHEMBL3260335 117473 0 None 2 4 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
ChEMBL 310 5 1 5 3.0 Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1 10.1021/ml500082j
1342 6824 49 None -33 19 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030030n
3 6824 49 None -33 19 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030030n
CHEMBL277120 6824 49 None -33 19 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm030030n
44327952 214823 0 None -1 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 367 5 3 3 2.6 CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 10.1021/jm030030n
CHEMBL97518 214823 0 None -1 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 367 5 3 3 2.6 CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 10.1021/jm030030n
44424665 92491 0 None 5 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 411 7 0 8 1.7 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
CHEMBL228882 92491 0 None 5 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 411 7 0 8 1.7 CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1 10.1016/j.bmc.2007.05.017
1342 6824 49 None -13 19 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm3003679
3 6824 49 None -13 19 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm3003679
CHEMBL277120 6824 49 None -13 19 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
ChEMBL 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 10.1021/jm3003679
122483212 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3763858 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765845 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
122483212 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3763858 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765845 144875 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 376 6 0 3 6.0 CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
155543653 179974 0 None -70 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
CHEMBL4522568 179974 0 None -70 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 348 4 1 7 2.0 CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2019.06.022
127028799 145016 0 None 6 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 444 6 2 5 1.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770293 145016 0 None 6 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 444 6 2 5 1.9 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
435595 62076 14 None 10 3 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 238 4 0 4 3.0 CN(C)CCSc1nc2ccccc2s1 10.1016/j.bmcl.2003.11.050
CHEMBL161846 62076 14 None 10 3 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
ChEMBL 238 4 0 4 3.0 CN(C)CCSc1nc2ccccc2s1 10.1016/j.bmcl.2003.11.050
129211 10521 78 None -151 16 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
2562 10521 78 None -151 16 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
488 10521 78 None -151 16 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
CHEMBL836 10521 78 None -151 16 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
DB00706 10521 78 None -151 16 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
127038282 143860 0 None 67 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 420 7 1 6 2.5 Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1 10.1016/j.ejmech.2015.11.040
CHEMBL3747117 143860 0 None 67 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 420 7 1 6 2.5 Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1 10.1016/j.ejmech.2015.11.040
155567307 182721 0 None -7 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 457 10 0 4 5.6 CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/j.bmcl.2019.06.029
CHEMBL4587772 182721 0 None -7 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 457 10 0 4 5.6 CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1 10.1016/j.bmcl.2019.06.029
156013695 184049 0 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4636210 184049 0 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 285 2 0 1 4.4 CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1 10.1016/j.bmc.2019.115262
90656678 117756 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 323 6 0 3 3.6 Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262412 117756 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 323 6 0 3 3.6 Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1 10.1016/j.ejmech.2014.04.034
44414722 87129 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 296 5 1 3 2.9 COc1ccccc1CC(c1ccccc1)N1CCNCC1 10.1016/j.bmcl.2010.04.052
CHEMBL214335 87129 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 296 5 1 3 2.9 COc1ccccc1CC(c1ccccc1)N1CCNCC1 10.1016/j.bmcl.2010.04.052
2477 7532 59 None -128 29 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmc.2019.115262
36 7532 59 None -128 29 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmc.2019.115262
437 7532 59 None -128 29 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmc.2019.115262
CHEMBL49 7532 59 None -128 29 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmc.2019.115262
DB00490 7532 59 None -128 29 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/j.bmc.2019.115262
2928642 169068 9 None -3 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 353 7 1 2 6.1 Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1 10.1016/j.ejmech.2018.04.010
CHEMBL4164143 169068 9 None -3 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 353 7 1 2 6.1 Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1 10.1016/j.ejmech.2018.04.010
2962174 169750 10 None -44 2 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 410 5 1 4 4.2 O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F 10.1016/j.ejmech.2018.04.010
CHEMBL4174981 169750 10 None -44 2 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
ChEMBL 410 5 1 4 4.2 O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F 10.1016/j.ejmech.2018.04.010
44276170 103092 0 None -25 4 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 0 5 3.9 COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
CHEMBL26135 103092 0 None -25 4 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
ChEMBL 382 9 0 5 3.9 COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/jm020994z
71456770 88140 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 9 1 4 4.6 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1 10.1016/j.ejmech.2012.07.043
CHEMBL2159313 88140 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 430 9 1 4 4.6 CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1 10.1016/j.ejmech.2012.07.043
145946620 174335 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4174681 174335 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
CHEMBL4300388 174335 0 None 3 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1 10.1016/j.ejmech.2018.01.093
155548275 180568 0 None -79 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 426 5 2 5 4.1 CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1 10.1016/j.ejmech.2019.06.001
CHEMBL4537701 180568 0 None -79 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 426 5 2 5 4.1 CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1 10.1016/j.ejmech.2019.06.001
144950987 186749 0 None -707 6 Human 4.1 pKi = 4.1 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 292 3 0 2 3.4 CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21 10.1016/j.bmcl.2020.127493
CHEMBL4746800 186749 0 None -707 6 Human 4.1 pKi = 4.1 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 292 3 0 2 3.4 CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21 10.1016/j.bmcl.2020.127493
37219401 144608 4 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 378 7 1 4 2.6 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
CHEMBL3759874 144608 4 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 378 7 1 4 2.6 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1 10.1016/j.ejmech.2015.11.040
164618100 192139 0 None -128 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4860275 192139 0 None -128 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
164612518 192173 0 None -41 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
CHEMBL4860719 192173 0 None -41 3 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 6 1 7 2.5 CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1 10.1016/j.ejmech.2020.112529
122483275 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764133 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765875 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
145975289 170358 0 None 16 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 472 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4203295 170358 0 None 16 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 472 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1 10.1021/acs.jmedchem.8b00828
122483275 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764133 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765875 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
127050699 147650 0 None 1 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 3 0 1 4.0 Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 10.1016/j.bmc.2016.05.053
CHEMBL3819082 147650 0 None 1 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 3 0 1 4.0 Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 10.1016/j.bmc.2016.05.053
CHEMBL3819726 147650 0 None 1 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
ChEMBL 295 3 0 1 4.0 Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 10.1016/j.bmc.2016.05.053
21071390 8768 53 None -10471 7 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 398 9 2 2 4.9 Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F 10.1016/j.ejmech.2019.111857
8689 8768 53 None -10471 7 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 398 9 2 2 4.9 Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F 10.1016/j.ejmech.2019.111857
CHEMBL3286580 8768 53 None -10471 7 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 398 9 2 2 4.9 Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F 10.1016/j.ejmech.2019.111857
DB11957 8768 53 None -10471 7 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 398 9 2 2 4.9 Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F 10.1016/j.ejmech.2019.111857
42618255 188355 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 428 6 0 6 3.6 COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1 10.1016/j.bmcl.2009.02.008
CHEMBL476862 188355 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 428 6 0 6 3.6 COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1 10.1016/j.bmcl.2009.02.008
71454898 87934 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 467 7 1 4 5.9 O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
CHEMBL2158025 87934 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 467 7 1 4 5.9 O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
162671167 190536 0 None -3 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 1 5 2.9 COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4790826 190536 0 None -3 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 1 5 2.9 COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803803 190536 0 None -3 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 397 9 1 5 2.9 COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1 10.1016/j.ejmech.2020.112437
56850926 78264 0 None -67 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 362 9 1 5 3.2 O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926759 78264 0 None -67 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 362 9 1 5 3.2 O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962491 78264 0 None -67 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 362 9 1 5 3.2 O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
134142907 152077 0 None 39 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 469 10 1 6 3.5 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3913100 152077 0 None 39 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 469 10 1 6 3.5 N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1 10.1016/j.ejmech.2016.05.005
4431 9506 25 None -20 12 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2021.113931
73 9506 25 None -20 12 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2021.113931
CHEMBL8618 9506 25 None -20 12 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.ejmech.2021.113931
118706290 127311 0 None -128 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3310116 127311 0 None -128 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2 10.1016/j.bmc.2014.05.027
CHEMBL3545468 127311 0 None -128 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 281 1 3 2 1.5 Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2 10.1016/j.bmc.2014.05.027
4431 9506 25 None -251 12 Rat 7.1 pKi = 7.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2004.09.029
73 9506 25 None -251 12 Rat 7.1 pKi = 7.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2004.09.029
CHEMBL8618 9506 25 None -251 12 Rat 7.1 pKi = 7.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2004.09.029
15629493 208825 1 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 233 4 0 2 2.9 CCN(CC)[C@@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
CHEMBL608536 208825 1 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 233 4 0 2 2.9 CCN(CC)[C@@H]1CCc2cccc(OC)c2C1 10.1021/jm030826m
122483275 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764133 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765875 144888 0 None -3 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 427 6 1 5 5.1 O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
3037629 191351 18 None -21 10 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 396 5 1 5 3.6 C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.1c00726
CHEMBL4848517 191351 18 None -21 10 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
ChEMBL 396 5 1 5 3.6 C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.1c00726
52952421 69356 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 479 6 1 6 5.5 O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1 10.1021/jm2000773
CHEMBL1782795 69356 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 479 6 1 6 5.5 O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1 10.1021/jm2000773
51352628 89602 10 None -4 3 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL 353 5 0 7 2.1 COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1 10.6019/CHEMBL4800727
CHEMBL2180408 89602 10 None -4 3 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL 353 5 0 7 2.1 COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1 10.6019/CHEMBL4800727
155530779 178349 0 None -11 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 8 2 4 4.8 COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1 10.1016/j.ejmech.2019.111857
CHEMBL4464881 178349 0 None -11 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 376 8 2 4 4.8 COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1 10.1016/j.ejmech.2019.111857
71462068 87948 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 443 6 1 4 4.8 O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
CHEMBL2158039 87948 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 443 6 1 4 4.8 O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1 10.1016/j.ejmech.2012.07.043
51352628 89602 10 None -4 3 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL 353 5 0 7 2.1 COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1 10.6019/CHEMBL4800727
CHEMBL2180408 89602 10 None -4 3 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A
ChEMBL 353 5 0 7 2.1 COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1 10.6019/CHEMBL4800727
126720394 169093 0 None -1230 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 355 4 1 5 3.1 CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1 10.1016/j.ejmech.2017.12.053
CHEMBL4164541 169093 0 None -1230 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 355 4 1 5 3.1 CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1 10.1016/j.ejmech.2017.12.053
10421583 105959 1 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 235 0 0 1 3.4 CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3 10.1021/jm9911433
CHEMBL281357 105959 1 None -1 5 Rat 7.1 pKi = 7.1 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
ChEMBL 235 0 0 1 3.4 CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3 10.1021/jm9911433
44460808 212326 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 335 3 0 3 3.0 CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1 10.1016/s0960-894x(02)00438-9
CHEMBL81041 212326 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 335 3 0 3 3.0 CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1 10.1016/s0960-894x(02)00438-9
21092408 75202 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
CHEMBL1917348 75202 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 395 7 1 4 3.4 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12 10.1016/j.bmc.2011.09.044
57395084 78326 0 None 1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1949964 78326 0 None 1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.bmc.2011.12.039
CHEMBL1963027 78326 0 None 1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter
ChEMBL 492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1 10.1016/j.bmc.2011.12.039
10421583 105959 1 None -1 5 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 235 0 0 1 3.4 CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3 10.1021/jm0108505
CHEMBL281357 105959 1 None -1 5 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 235 0 0 1 3.4 CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3 10.1021/jm0108505
118728528 124502 0 None -27 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 0 6 4.7 Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
CHEMBL3401491 124502 0 None -27 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
ChEMBL 444 7 0 6 4.7 Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C 10.1016/j.bmcl.2015.02.042
135367404 171334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4215197 171334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
118709751 120318 0 None -691 10 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F 10.1016/j.bmcl.2014.07.018
CHEMBL3321792 120318 0 None -691 10 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F 10.1016/j.bmcl.2014.07.018
122483249 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3764970 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
CHEMBL3765842 144872 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.3 CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1 10.1016/j.ejmech.2016.01.043
135367817 170334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4202995 170334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
32354149 171172 0 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 374 7 1 4 2.8 Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4213238 171172 0 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 374 7 1 4 2.8 Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
47556338 173592 0 None 1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 397 5 2 4 2.0 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O 10.1039/C8MD00168E
CHEMBL4284656 173592 0 None 1 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method
ChEMBL 397 5 2 4 2.0 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O 10.1039/C8MD00168E
9843889 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/acs.jmedchem.7b01898
CHEMBL12259 23078 0 None 1 2 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/acs.jmedchem.7b01898
127028153 144941 0 None 33 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 456 7 2 6 1.8 COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
CHEMBL3769441 144941 0 None 33 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 456 7 2 6 1.8 COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 10.1016/j.ejmech.2016.02.024
156015769 184358 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 388 4 1 5 2.8 COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
CHEMBL4640588 184358 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 388 4 1 5 2.8 COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 10.1016/j.bmc.2020.115578
9843889 23078 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL12259 23078 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1016/j.ejmech.2014.08.023
9843889 23078 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
CHEMBL12259 23078 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells
ChEMBL 399 7 0 3 4.8 O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1 10.1021/jm8014553
145946714 174337 0 None -6 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4213352 174337 0 None -6 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
CHEMBL4300399 174337 0 None -6 6 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 10.1016/j.bmcl.2018.04.059
50878551 97520 61 None 1 18 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL2391541 97520 61 None 1 18 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2015.12.053
242 7258 124 None -14 51 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2020.112709
34 7258 124 None -14 51 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2020.112709
60795 7258 124 None -14 51 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2020.112709
CHEMBL1112 7258 124 None -14 51 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2020.112709
DB01238 7258 124 None -14 51 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.ejmech.2020.112709
135367817 170334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
CHEMBL4202995 170334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 247 1 2 2 2.4 Clc1cccc(-c2n[nH]c3c2CCNCC3)c1 10.1021/acs.jmedchem.8b00642
135367404 171334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
CHEMBL4215197 171334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
ChEMBL 227 1 2 2 2.1 Cc1ccccc1-c1n[nH]c2c1CCNCC2 10.1021/acs.jmedchem.8b00642
155512487 176448 3 None -446 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 350 6 3 3 4.6 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
CHEMBL4437523 176448 3 None -446 5 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 350 6 3 3 4.6 Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1 10.1016/j.ejmech.2019.111857
12088082 71900 0 None 17 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 353 7 3 7 2.8 C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
CHEMBL182418 71900 0 None 17 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
ChEMBL 353 7 3 7 2.8 C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1 10.1016/j.bmcl.2004.06.008
44461048 174941 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 375 5 0 3 3.8 Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
CHEMBL433134 174941 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
ChEMBL 375 5 0 3 3.8 Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1 10.1016/s0960-894x(02)00438-9
135398737 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm990550b
38 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm990550b
722 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm990550b
CHEMBL42 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm990550b
DB00363 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm990550b
127025244 144533 0 None 11 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 464 8 1 4 4.4 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1 10.1016/j.ejmech.2015.11.040
CHEMBL3759262 144533 0 None 11 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
ChEMBL 464 8 1 4 4.4 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1 10.1016/j.ejmech.2015.11.040
127041244 143850 0 None 6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 416 8 0 4 4.0 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2015.11.041
CHEMBL3747052 143850 0 None 6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
ChEMBL 416 8 0 4 4.0 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmc.2015.11.041
145984299 172531 0 None -63 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4246655 172531 0 None -63 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 507 6 0 7 4.2 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.ejmech.2018.01.002
71456782 88211 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 364 7 1 4 2.3 O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
CHEMBL2159479 88211 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 364 7 1 4 2.3 O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1 10.1016/j.ejmech.2012.07.043
71453280 88215 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 8 1 4 4.1 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F 10.1016/j.ejmech.2012.07.043
CHEMBL2159483 88215 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 458 8 1 4 4.1 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F 10.1016/j.ejmech.2012.07.043
118731363 124977 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 566 8 0 5 4.5 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409046 124977 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 566 8 0 5 4.5 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
118731364 124978 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 578 9 0 4 6.0 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409047 124978 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 578 9 0 4 6.0 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 10.1016/j.ejmech.2014.12.041
118731366 124980 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 594 10 0 5 5.2 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
CHEMBL3409049 124980 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
ChEMBL 594 10 0 5 5.2 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1 10.1016/j.ejmech.2014.12.041
145947456 174429 0 None 33 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 467 6 2 6 2.2 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4174055 174429 0 None 33 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 467 6 2 6 2.2 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
CHEMBL4301717 174429 0 None 33 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 467 6 2 6 2.2 CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O 10.1016/j.ejmech.2018.01.093
156017281 184444 0 None -8 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 466 8 0 6 4.0 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
CHEMBL4641609 184444 0 None -8 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 466 8 0 6 4.0 O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 10.1016/j.bmc.2020.115459
122377930 143430 0 None 11 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 420 8 1 4 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1039/C5MD00166H
CHEMBL3740054 143430 0 None 11 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 420 8 1 4 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1 10.1039/C5MD00166H
127041107 143579 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 487 8 1 5 4.7 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12 10.1039/C5MD00166H
CHEMBL3741445 143579 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay
ChEMBL 487 8 1 5 4.7 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12 10.1039/C5MD00166H
11460460 189141 0 None -8 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 289 2 1 3 3.5 CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4784845 189141 0 None -8 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 289 2 1 3 3.5 CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
66800947 165012 0 None -8 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 433 6 2 3 4.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4088249 165012 0 None -8 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 433 6 2 3 4.0 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 10.1021/acs.jmedchem.7b00839
11397799 91508 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 421 8 1 4 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
CHEMBL222864 91508 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 421 8 1 4 4.2 COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1 10.1016/j.ejmech.2014.08.023
11326570 83495 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 383 7 0 3 4.7 O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
CHEMBL206563 83495 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 383 7 0 3 4.7 O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1 10.1016/j.bmcl.2005.11.067
44326733 118406 0 None 512 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 306 2 2 3 3.3 c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3 10.1016/j.bmcl.2007.01.093
CHEMBL328476 118406 0 None 512 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 306 2 2 3 3.3 c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3 10.1016/j.bmcl.2007.01.093
66801605 118842 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 520 8 1 7 5.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3289960 118842 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 520 8 1 7 5.0 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
25107579 194221 0 None -1 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 436 10 1 5 4.3 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
CHEMBL493909 194221 0 None -1 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
ChEMBL 436 10 1 5 4.3 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 10.1021/jm800615e
24854266 103025 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm200547z
CHEMBL261009 103025 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm200547z
24854266 103025 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm070279v
CHEMBL261009 103025 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 463 7 1 3 5.7 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 10.1021/jm070279v
155567476 182677 0 None 251 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 450 7 1 6 4.4 O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4586787 182677 0 None 251 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 450 7 1 6 4.4 O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
10324985 83556 8 None -6 17 Human 8.0 pKi = 8.0 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
CHEMBL199824 83556 8 None -6 17 Human 8.0 pKi = 8.0 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
CHEMBL2068762 83556 8 None -6 17 Human 8.0 pKi = 8.0 Binding
Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
44266244 214851 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 378 5 0 3 3.9 Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1 10.1016/s0960-894x(03)00077-5
CHEMBL9770 214851 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 378 5 0 3 3.9 Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1 10.1016/s0960-894x(03)00077-5
CHEMBL5074880 221118 0 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis
ChEMBL None None None CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 10.1021/acs.jmedchem.1c00110
44266164 213965 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 423 4 0 5 3.5 O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
CHEMBL9250 213965 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
ChEMBL 423 4 0 5 3.5 O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 10.1016/s0960-894x(03)00077-5
155515687 176749 0 None -2 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 452 6 1 5 4.9 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
CHEMBL4441943 176749 0 None -2 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
ChEMBL 452 6 1 5 4.9 O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12 10.1016/j.ejmech.2019.111690
24854270 102629 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm070279v
CHEMBL259009 102629 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm070279v
134136134 151215 0 None 6 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 584 15 1 6 5.5 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1 10.1016/j.ejmech.2016.05.005
CHEMBL3906408 151215 0 None 6 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
ChEMBL 584 15 1 6 5.5 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1 10.1016/j.ejmech.2016.05.005
156020950 184901 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 251 2 0 1 3.8 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
CHEMBL4648289 184901 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 251 2 0 1 3.8 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1 10.1016/j.bmc.2019.115262
11525867 103001 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm200547z
CHEMBL260870 103001 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 479 7 1 3 6.2 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 10.1021/jm200547z
66801160 118829 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 468 7 1 6 3.6 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3289947 118829 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 468 7 1 6 3.6 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
1621 9207 17 None -34 44 Rat 8.0 pKi = 8.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030826m
17 9207 17 None -34 44 Rat 8.0 pKi = 8.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030826m
5761 9207 17 None -34 44 Rat 8.0 pKi = 8.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030826m
CHEMBL263881 9207 17 None -34 44 Rat 8.0 pKi = 8.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030826m
DB04829 9207 17 None -34 44 Rat 8.0 pKi = 8.0 Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm030826m
118753672 127396 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)
ChEMBL 394 6 0 3 4.9 CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.bmc.2013.06.020
CHEMBL2413451 127396 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)
ChEMBL 394 6 0 3 4.9 CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.bmc.2013.06.020
CHEMBL3546228 127396 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)
ChEMBL 394 6 0 3 4.9 CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.bmc.2013.06.020
11740526 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/acs.jmedchem.2c00633
CHEMBL2311141 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/acs.jmedchem.2c00633
CHEMBL85602 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/acs.jmedchem.2c00633
11740526 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.ejmech.2011.05.010
CHEMBL2311141 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.ejmech.2011.05.010
CHEMBL85602 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/j.ejmech.2011.05.010
11740526 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/s0960-894x(02)00485-7
CHEMBL2311141 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/s0960-894x(02)00485-7
CHEMBL85602 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1016/s0960-894x(02)00485-7
162647173 186410 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 10.1016/j.ejmech.2020.112149
CHEMBL4742856 186410 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 438 7 1 6 3.3 Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 10.1016/j.ejmech.2020.112149
11740526 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/jm070279v
CHEMBL2311141 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/jm070279v
CHEMBL85602 212866 0 None 79 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
ChEMBL 380 5 0 3 4.5 CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32 10.1021/jm070279v
10064053 102682 0 None -5 6 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 311 1 0 1 5.1 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3 10.1021/jm030030n
CHEMBL25924 102682 0 None -5 6 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
ChEMBL 311 1 0 1 5.1 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3 10.1021/jm030030n
10064053 102682 0 None -5 6 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 311 1 0 1 5.1 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3 10.1021/jm0108505
CHEMBL25924 102682 0 None -5 6 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
ChEMBL 311 1 0 1 5.1 CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3 10.1021/jm0108505
2470 10425 50 None -389 58 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
3300 10425 50 None -389 58 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
5265 10425 50 None -389 58 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
99 10425 50 None -389 58 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
CHEMBL267930 10425 50 None -389 58 Rat 8.0 pKi = 8 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm030030n
156016177 184433 0 None 18 7 Human 8.0 pKi = 8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 10.1016/j.bmc.2020.115578
CHEMBL4641502 184433 0 None 18 7 Human 8.0 pKi = 8 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 10.1016/j.bmc.2020.115578
66801173 118840 0 None -1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 486 8 1 7 4.4 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
CHEMBL3289958 118840 0 None -1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 486 8 1 7 4.4 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1 10.1021/jm401895u
66801226 118854 0 None 9 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 452 7 1 6 3.1 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
CHEMBL3289971 118854 0 None 9 3 Human 8.0 pKi = 8 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 452 7 1 6 3.1 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 10.1021/jm401895u
3994476 105752 9 None -13 5 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 345 7 0 5 1.7 COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 10.1016/j.ejmech.2021.113931
CHEMBL279841 105752 9 None -13 5 Human 7.1 pKi = 7.1 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 345 7 0 5 1.7 COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 10.1016/j.ejmech.2021.113931
57399091 75198 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 440 8 1 6 2.7 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2011.09.044
CHEMBL1917344 75198 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 440 8 1 6 2.7 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2011.09.044
11380477 186461 0 None -17 4 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 280 2 1 4 2.7 CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
CHEMBL4743582 186461 0 None -17 4 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 280 2 1 4 2.7 CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2 10.1016/j.bmcl.2020.127669
11288612 189390 0 None -29 4 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 267 2 1 3 3.0 c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
CHEMBL4788327 189390 0 None -29 4 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
ChEMBL 267 2 1 3 3.0 c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 10.1016/j.bmcl.2020.127669
44209480 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2020.115943
CHEMBL1940418 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2020.115943
56944862 163547 0 None -19 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
CHEMBL4070715 163547 0 None -19 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 477 8 2 3 5.3 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.7b00839
44209480 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
CHEMBL1940418 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.ejmech.2021.113243
44209480 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
CHEMBL1940418 76945 0 None -81 11 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2011.12.019
145947560 174487 0 None -4 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
CHEMBL4212812 174487 0 None -4 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
CHEMBL4302457 174487 0 None -4 5 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
ChEMBL 344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl 10.1016/j.bmcl.2018.04.059
3994476 105752 9 None -13 5 Rat 7.1 pKi = 7.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 345 7 0 5 1.7 COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL279841 105752 9 None -13 5 Rat 7.1 pKi = 7.1 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 345 7 0 5 1.7 COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
90656671 117767 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 387 7 1 4 4.7 Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262423 117767 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 387 7 1 4 4.7 Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1 10.1016/j.ejmech.2014.04.034
90644078 118866 0 None -29 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 490 7 1 7 4.2 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
CHEMBL3289983 118866 0 None -29 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 490 7 1 7 4.2 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 10.1021/jm401895u
145963863 171006 0 None 2 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1 10.1021/acs.jmedchem.8b00828
CHEMBL4211094 171006 0 None 2 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 438 7 1 4 3.3 O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1 10.1021/acs.jmedchem.8b00828
42618254 188795 0 None -1 2 Human 6.0 pKi = 6.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 412 5 0 5 3.9 Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.bmcl.2009.02.008
CHEMBL478073 188795 0 None -1 2 Human 6.0 pKi = 6.0 Binding
Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay
ChEMBL 412 5 0 5 3.9 Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21 10.1016/j.bmcl.2009.02.008
127029375 145040 0 None 4 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 460 6 2 5 2.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
CHEMBL3770522 145040 0 None 4 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
ChEMBL 460 6 2 5 2.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O 10.1016/j.ejmech.2016.02.024
134155461 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3959209 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3990475 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
66800965 164973 0 None -50 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 461 8 2 3 4.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4087852 164973 0 None -50 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 461 8 2 3 4.8 O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 10.1021/acs.jmedchem.7b00839
134155461 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3959209 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
CHEMBL3990475 161266 0 None -1 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
ChEMBL 291 4 1 2 3.6 c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 10.1016/j.bmc.2016.09.019
156011357 184117 0 None 2 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 387 2 0 1 5.8 CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmc.2019.115262
CHEMBL4637353 184117 0 None 2 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 387 2 0 1 5.8 CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmc.2019.115262
44395797 73560 0 None -2 2 Rat 6.0 pKi = 6.0 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 6 0 5 2.7 COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
CHEMBL185936 73560 0 None -2 2 Rat 6.0 pKi = 6.0 Binding
In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
ChEMBL 393 6 0 5 2.7 COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1 10.1016/j.bmcl.2004.09.029
155566855 183021 0 None -645 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4586353 183021 0 None -645 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
CHEMBL4594758 183021 0 None -645 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
ChEMBL 352 3 2 5 3.2 Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1016/j.ejmech.2019.06.001
52952307 69363 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 477 7 1 6 5.7 O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12 10.1021/jm2000773
CHEMBL1782806 69363 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 477 7 1 6 5.7 O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12 10.1021/jm2000773
52952200 69358 0 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 413 6 0 6 4.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12 10.1021/jm2000773
CHEMBL1782798 69358 0 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 413 6 0 6 4.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12 10.1021/jm2000773
118709750 120317 0 None -83 9 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 10.1016/j.bmcl.2014.07.018
CHEMBL3321791 120317 0 None -83 9 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 10.1016/j.bmcl.2014.07.018
76310813 113174 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 364 4 0 2 5.9 C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1 10.1016/j.ejmech.2014.01.055
CHEMBL3121433 113174 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 364 4 0 2 5.9 C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1 10.1016/j.ejmech.2014.01.055
CHEMBL3139442 113174 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 364 4 0 2 5.9 C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1 10.1016/j.ejmech.2014.01.055
11454449 91499 0 None 2 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 7 1 4 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
CHEMBL222807 91499 0 None 2 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 407 7 1 4 3.8 COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1 10.1021/jm049702f
44401042 131607 0 None -24 9 Human 7.0 pKi = 7.0 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.6 CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 10.1021/jm049632c
CHEMBL364270 131607 0 None -24 9 Human 7.0 pKi = 7.0 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
ChEMBL 329 2 0 3 4.6 CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 10.1021/jm049632c
90656670 117768 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 401 8 1 4 4.6 Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262424 117768 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 401 8 1 4 4.6 Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1 10.1016/j.ejmech.2014.04.034
155554036 180980 0 None -72 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 334 4 1 7 1.4 CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4548041 180980 0 None -72 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 334 4 1 7 1.4 CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
162671630 190539 0 None -32 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 467 9 1 6 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4791207 190539 0 None -32 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 467 9 1 6 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4803834 190539 0 None -32 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 467 9 1 6 4.6 COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1 10.1016/j.ejmech.2020.112437
66801053 190215 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 470 8 2 7 3.1 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12 10.1016/j.ejmech.2020.112437
CHEMBL4798767 190215 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
ChEMBL 470 8 2 7 3.1 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12 10.1016/j.ejmech.2020.112437
122181250 128632 0 None -1 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 418 6 1 4 3.0 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
CHEMBL3589976 128632 0 None -1 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis
ChEMBL 418 6 1 4 3.0 O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2015.04.026
71460453 88137 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 488 8 1 4 5.2 O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159310 88137 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 488 8 1 4 5.2 O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
60195994 88587 2 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 266 2 1 2 3.4 Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C 10.1021/jm3003679
CHEMBL2164335 88587 2 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 266 2 1 2 3.4 Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C 10.1021/jm3003679
145964390 171087 0 None 95 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 564 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
CHEMBL4212254 171087 0 None 95 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 564 7 1 4 3.9 O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1 10.1021/acs.jmedchem.8b00828
162659287 188068 0 None -85 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 459 7 1 6 4.2 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 10.1016/j.ejmech.2020.112149
CHEMBL4762226 188068 0 None -85 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
ChEMBL 459 7 1 6 4.2 O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 10.1016/j.ejmech.2020.112149
53245590 99174 43 None -2 4 Human 6.0 pKi = 6.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431120 99174 43 None -2 4 Human 6.0 pKi = 6.0 Binding
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
145976946 170713 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 416 7 1 4 3.8 CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
CHEMBL4207568 170713 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay
ChEMBL 416 7 1 4 3.8 CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1 10.1021/acs.jmedchem.8b00828
155538350 179159 0 None -20 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 466 9 1 8 2.0 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
CHEMBL4476370 179159 0 None -20 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
ChEMBL 466 9 1 8 2.0 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC 10.1016/j.bmc.2019.07.046
164611003 192123 0 None -87 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4860006 192123 0 None -87 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 382 4 1 7 2.7 CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
56850796 78307 0 None -7 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 8 1 4 2.6 O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1926686 78307 0 None -7 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 8 1 4 2.6 O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
CHEMBL1962913 78307 0 None -7 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins
ChEMBL 371 8 1 4 2.6 O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1 10.1021/jm2007886
76332585 113178 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3121441 113178 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1 10.1016/j.ejmech.2014.01.055
CHEMBL3139446 113178 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
ChEMBL 381 4 0 3 5.3 Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1 10.1016/j.ejmech.2014.01.055
11674602 75189 2 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 344 7 1 3 2.8 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
CHEMBL1917335 75189 2 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 344 7 1 3 2.8 O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1 10.1016/j.bmc.2011.09.044
145947627 174470 0 None 10 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 528 9 2 6 3.2 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4163626 174470 0 None 10 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 528 9 2 6 3.2 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
CHEMBL4302240 174470 0 None 10 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
ChEMBL 528 9 2 6 3.2 COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1 10.1016/j.ejmech.2018.01.093
90644076 118858 0 None -1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 406 7 1 7 2.4 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
CHEMBL3289975 118858 0 None -1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
ChEMBL 406 7 1 7 2.4 O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1 10.1021/jm401895u
134131147 149009 0 None -5 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 8 0 5 4.6 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.12.039
CHEMBL3884584 149009 0 None -5 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 436 8 0 5 4.6 O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.12.039
168282733 197838 0 None -79 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 386 9 3 9 1.4 COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
CHEMBL5187317 197838 0 None -79 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 386 9 3 9 1.4 COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1 10.1016/j.ejmech.2021.113931
164628531 193243 0 None -131 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
CHEMBL4876727 193243 0 None -131 3 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method
ChEMBL 396 5 1 7 3.0 CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 10.1016/j.ejmech.2020.112529
122483229 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764477 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765850 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
90654684 116882 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 502 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
CHEMBL3235756 116882 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
ChEMBL 502 8 1 4 4.1 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1016/j.ejmech.2014.03.005
90654831 116603 0 None -17 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 512 9 0 5 4.4 CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
CHEMBL3233401 116603 0 None -17 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
ChEMBL 512 9 0 5 4.4 CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2014.01.065
137635884 162679 0 None -5 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 427 7 2 3 4.1 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL4060649 162679 0 None -5 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
ChEMBL 427 7 2 3 4.1 Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 10.1021/acs.jmedchem.7b00839
CHEMBL5087742 221895 0 None -22 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method
ChEMBL None None None C[C@H]1C[C@H](NS(=O)(=O)c2csc3ccccc23)CN1CCCc1noc2cc(F)ccc12 10.1021/acs.jmedchem.1c00497
90656702 119386 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 435 9 1 4 5.2 CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3262433 119386 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 435 9 1 4 5.2 CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
CHEMBL3302235 119386 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
ChEMBL 435 9 1 4 5.2 CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1 10.1016/j.ejmech.2014.04.034
4713248 214686 3 None 2 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 281 5 2 3 1.2 CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1 10.1021/jm030030n
CHEMBL96729 214686 3 None 2 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
ChEMBL 281 5 2 3 1.2 CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1 10.1021/jm030030n
155531846 178424 0 None -18 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 300 4 1 7 0.8 CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4465929 178424 0 None -18 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 300 4 1 7 0.8 CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1 10.1016/j.ejmech.2019.06.022
162676589 190569 0 None -6 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4800511 190569 0 None -6 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
CHEMBL4804122 190569 0 None -6 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
ChEMBL 395 8 1 4 4.4 COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1 10.1016/j.ejmech.2020.112437
164613772 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4859722 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL5028215 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
122483229 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3764477 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
CHEMBL3765850 144880 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL 348 5 0 3 5.5 O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21 10.1016/j.ejmech.2016.01.043
45028192 69361 1 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 416 5 0 6 4.6 O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12 10.1021/jm2000773
CHEMBL1782801 69361 1 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 416 5 0 6 4.6 O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12 10.1021/jm2000773
7125890 124716 12 None -6 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 408 4 1 4 5.8 Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1 10.1016/j.bmcl.2015.03.049
CHEMBL3403341 124716 12 None -6 4 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM
ChEMBL 408 4 1 4 5.8 Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1 10.1016/j.bmcl.2015.03.049
164613772 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL4859722 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
CHEMBL5028215 195269 0 None -2 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method
ChEMBL 380 6 1 5 2.9 O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1 10.1016/j.ejmech.2021.113243
155562652 181940 0 None -15 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 552 9 1 7 5.3 COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1 10.1016/j.ejmech.2019.01.031
CHEMBL4570209 181940 0 None -15 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis
ChEMBL 552 9 1 7 5.3 COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1 10.1016/j.ejmech.2019.01.031
60196076 88593 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 298 4 1 4 2.8 COc1cccc(OC)c1-c1ccccc1N1CCNCC1 10.1021/jm3003679
CHEMBL2164342 88593 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
ChEMBL 298 4 1 4 2.8 COc1cccc(OC)c1-c1ccccc1N1CCNCC1 10.1021/jm3003679
44408805 83513 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 335 6 0 3 3.8 O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1 10.1016/j.bmcl.2005.11.067
CHEMBL206667 83513 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells
ChEMBL 335 6 0 3 3.8 O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1 10.1016/j.bmcl.2005.11.067
54758203 72768 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 497 7 1 3 6.4 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl 10.1021/jm200547z
CHEMBL1836783 72768 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
ChEMBL 497 7 1 3 6.4 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl 10.1021/jm200547z
118626140 172697 0 None -7 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
CHEMBL4250244 172697 0 None -7 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
ChEMBL 520 6 1 4 5.7 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 10.1016/j.ejmech.2018.01.002
71456779 88185 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 7 1 4 3.7 O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
CHEMBL2159454 88185 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
ChEMBL 450 7 1 4 3.7 O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1 10.1016/j.ejmech.2012.07.043
156017999 184598 0 None 6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 302 2 0 2 4.3 CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1 10.1016/j.bmc.2019.115262
CHEMBL4643725 184598 0 None 6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
ChEMBL 302 2 0 2 4.3 CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1 10.1016/j.bmc.2019.115262
164628882 193229 0 None -48 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 477 6 0 6 3.4 COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL4876545 193229 0 None -48 5 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
ChEMBL 477 6 0 6 3.4 COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1 10.1016/j.bmcl.2021.128028
56649650 74633 0 None -112 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 466 8 0 5 4.2 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910141 74633 0 None -112 8 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 466 8 0 5 4.2 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
13091359 120316 0 None -138 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
CHEMBL3321790 120316 0 None -138 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting
ChEMBL 405 6 1 3 5.5 OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 10.1016/j.bmcl.2014.07.018
44455973 104244 7 None -1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 209 1 2 3 2.3 CCC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.080
CHEMBL270176 104244 7 None -1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
ChEMBL 209 1 2 3 2.3 CCC1NC(N)=Nc2cccc(Cl)c21 10.1016/j.bmcl.2007.10.080
10960943 211039 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 428 7 1 3 5.4 CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
CHEMBL71165 211039 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
ChEMBL 428 7 1 3 5.4 CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 10.1021/jm0104264
11488153 91915 0 None 2 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
CHEMBL224935 91915 0 None 2 2 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
ChEMBL 430 8 1 4 4.4 N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 10.1021/jm049702f
198967 98549 57 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 248 1 2 1 3.4 c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1 10.1016/j.bmcl.2007.01.093
CHEMBL241083 98549 57 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
ChEMBL 248 1 2 1 3.4 c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1 10.1016/j.bmcl.2007.01.093
CHEMBL5285633 201084 0 None -2 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 450 7 0 5 4.2 O=C1CC2CCCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmc.2023.117256
44424655 150068 0 None -1 2 Rat 6.0 pKi = 6.0 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 440 8 0 9 1.4 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
CHEMBL389700 150068 0 None -1 2 Rat 6.0 pKi = 6.0 Binding
Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane
ChEMBL 440 8 0 9 1.4 CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.05.017
60167309 82072 0 None -6 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 400 6 1 4 5.3 OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.ejmech.2012.03.042
CHEMBL2037432 82072 0 None -6 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting
ChEMBL 400 6 1 4 5.3 OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.ejmech.2012.03.042
60167309 82072 0 None -6 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 400 6 1 4 5.3 OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
CHEMBL2037432 82072 0 None -6 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method
ChEMBL 400 6 1 4 5.3 OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 10.1016/j.bmc.2016.06.011
168295839 199024 0 None -12 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 370 9 3 8 1.8 Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
CHEMBL5205324 199024 0 None -12 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis
ChEMBL 370 9 3 8 1.8 Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1 10.1016/j.ejmech.2021.113931
156010295 183914 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 306 3 0 2 4.3 CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3 10.1016/j.bmc.2020.115578
CHEMBL4633889 183914 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
ChEMBL 306 3 0 2 4.3 CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3 10.1016/j.bmc.2020.115578
155515324 176734 0 None -27 4 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 382 4 1 8 0.8 CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
CHEMBL4441655 176734 0 None -27 4 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay
ChEMBL 382 4 1 8 0.8 CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1 10.1016/j.ejmech.2019.06.022
155519393 177198 0 None -97 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 397 7 2 4 5.3 COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1 10.1016/j.ejmech.2019.111857
CHEMBL4448285 177198 0 None -97 5 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
ChEMBL 397 7 2 4 5.3 COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1 10.1016/j.ejmech.2019.111857
156019370 184736 0 None -25 5 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 422 9 1 5 4.4 O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1 10.1016/j.bmc.2020.115459
CHEMBL4645793 184736 0 None -25 5 Human 7.0 pKi = 7 Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
ChEMBL 422 9 1 5 4.4 O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1 10.1016/j.bmc.2020.115459
134131159 149025 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 416 10 0 5 4.5 c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1 10.1016/j.bmc.2016.12.039
CHEMBL3884743 149025 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
ChEMBL 416 10 0 5 4.5 c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1 10.1016/j.bmc.2016.12.039
57397411 75205 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 4 3.8 O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL1917351 75205 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
ChEMBL 401 7 1 4 3.8 O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1 10.1016/j.bmc.2011.09.044
CHEMBL5265814 200233 0 None -1 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
ChEMBL 436 7 0 5 3.8 O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1 10.1016/j.bmc.2023.117256
1621 9207 17 None -22 44 Human 8.1 pKd = 8.1 Binding
GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 None -22 44 Human 8.1 pKd = 8.1 Binding
GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 None -22 44 Human 8.1 pKd = 8.1 Binding
GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 None -22 44 Human 8.1 pKd = 8.1 Binding
GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 None -22 44 Human 8.1 pKd = 8.1 Binding
GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
3233 10285 44 None 2 12 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
3247 10285 44 None 2 12 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
6604889 10285 44 None 2 12 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
CHEMBL282199 10285 44 None 2 12 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
DB13988 10285 44 None 2 12 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
284 9689 69 None 457 2 Human 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 15 1 1 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)N 10571256
5283387 9689 69 None 457 2 Human 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 15 1 1 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)N 10571256
CHEMBL15927 9689 69 None 457 2 Human 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 15 1 1 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)N 10571256
2389 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 7908055
2389 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8997630
5073 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 7908055
5073 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8997630
96 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 7908055
96 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8997630
CHEMBL85 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 7908055
CHEMBL85 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8997630
DB00734 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 7908055
DB00734 10104 118 None -7 66 Rat 9.0 pKd None 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8997630
1809 6922 32 3H-MESULERGINE -2 37 Rat 11.4 pKi = 11.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-MESULERGINE -2 37 Rat 11.4 pKi = 11.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-MESULERGINE -2 37 Rat 11.4 pKi = 11.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-MESULERGINE 2 37 Guinea pig 12.1 pKi = 12.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-MESULERGINE 2 37 Guinea pig 12.1 pKi = 12.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-MESULERGINE 2 37 Guinea pig 12.1 pKi = 12.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
5 6927 72 3H-MESULERGINE 3 53 Guinea pig 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-MESULERGINE 3 53 Guinea pig 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-MESULERGINE 3 53 Guinea pig 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-MESULERGINE 3 53 Guinea pig 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
1809 6922 32 3H-5HT -7 37 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-5HT -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 UNDEFINED -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -7 37 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 UNDEFINED -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -7 37 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 UNDEFINED -2 37 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
23643664 9129 8 UNDEFINED -1 5 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
8434 9129 8 UNDEFINED -1 5 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
CHEMBL243954 9129 8 UNDEFINED -1 5 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
5 6927 72 3H-MESULERGINE -5 53 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-MESULERGINE -5 53 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-MESULERGINE -5 53 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-MESULERGINE -5 53 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
1809 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -2 37 Rat 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-5CT 2 37 Guinea pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5CT 2 37 Guinea pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5CT 2 37 Guinea pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
5 6927 72 3H-5CT 3 53 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5CT 3 53 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5CT 3 53 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5CT 3 53 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-MESULERGINE 1 31 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-MESULERGINE 1 31 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-MESULERGINE 1 31 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1809 6922 32 125I-LSD -2 37 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 125I-LSD -2 37 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 125I-LSD -2 37 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4106 9280 22 3H-5HT -2 33 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -2 33 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -2 33 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -2 33 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
1238 209953 24 3H-LSD 1 16 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL64249 209953 24 3H-LSD 1 16 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
1809 6922 32 3H-5HT 2 37 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT 2 37 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT 2 37 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1621 9207 17 3H-MESULERGINE -1 44 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 3H-MESULERGINE -1 44 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 3H-MESULERGINE -1 44 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 3H-MESULERGINE -1 44 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 3H-MESULERGINE -1 44 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2389 10104 118 3H-MESULERGINE -1 66 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2389 10104 118 3H-5-CT -8 66 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-MESULERGINE -1 66 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-5-CT -8 66 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-MESULERGINE -1 66 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-5-CT -8 66 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-MESULERGINE -1 66 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-5-CT -8 66 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-MESULERGINE -1 66 Guinea pig 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-5-CT -8 66 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
1809 6922 32 125I-LSD -2 37 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 125I-LSD -2 37 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 125I-LSD -2 37 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 UNDEFINED -2 37 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 UNDEFINED -2 37 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 UNDEFINED -2 37 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
16362 9899 71 3H-LSD -11 29 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
16362 9899 71 3H-LSD -5 29 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 3H-LSD -11 29 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 3H-LSD -5 29 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 3H-LSD -11 29 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 3H-LSD -5 29 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 3H-LSD -11 29 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 3H-LSD -5 29 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 3H-LSD -11 29 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 3H-LSD -5 29 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
107 6929 121 3H-5CT 1 31 Guinea pig 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5CT 1 31 Guinea pig 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5CT 1 31 Guinea pig 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1588 9105 27 125I-LSD -6 44 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 125I-LSD -6 44 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 125I-LSD -6 44 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 125I-LSD -6 44 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 125I-LSD -6 44 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
107 6929 121 3H-5HT -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
25107716 9130 43 UNDEFINED 3 7 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
8436 9130 43 UNDEFINED 3 7 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
CHEMBL522691 9130 43 UNDEFINED 3 7 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 None
5 6927 72 3H-5HT -3 53 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5 6927 72 3H-5HT -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5 6927 72 UNDEFINED -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -3 53 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 UNDEFINED -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -3 53 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 UNDEFINED -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -3 53 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 UNDEFINED -5 53 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-MESULERGINE -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-MESULERGINE -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-MESULERGINE -1 31 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
101 10594 24 3H-LSD -2 14 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 None
55752 10594 24 3H-LSD -2 14 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL35057 10594 24 3H-LSD -2 14 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 None
4106 9280 22 125I-LSD -2 33 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 125I-LSD -2 33 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 125I-LSD -2 33 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 125I-LSD -2 33 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
46780481 114308 20 3H-5HT -4 53 Mouse 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-5HT -4 53 Mouse 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-5HT -4 53 Mouse 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-5HT -4 53 Mouse 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
1809 6922 32 3H-5CT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5CT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5CT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
25107518 194063 0 UNDEFINED 20 4 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 None
CHEMBL492871 194063 0 UNDEFINED 20 4 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 None
1809 6922 32 125I-LSD -2 37 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 125I-LSD -2 37 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 125I-LSD -2 37 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1588 9105 27 3H-5HT -6 44 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-5HT -6 44 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-5HT -6 44 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-5HT -6 44 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-5HT -6 44 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
1809 6922 32 3H-5HT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -7 37 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
23643870 99639 0 UNDEFINED 35 3 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243955 99639 0 UNDEFINED 35 3 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
46780481 114308 20 3H-LSD -16 53 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-LSD -16 53 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-LSD -16 53 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-LSD -16 53 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
1809 6922 32 3H-5HT -7 37 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -7 37 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -7 37 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
107 6929 121 UNDEFINED -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 UNDEFINED -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 UNDEFINED -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
2389 10104 118 3H-LSD -7 66 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -7 66 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -7 66 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -7 66 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -7 66 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
107 6929 121 3H-5HT -3 31 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
107 6929 121 3H-5HT -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -3 31 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -3 31 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -1 31 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1809 6922 32 3H-5CT 2 37 Guinea pig 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5CT 2 37 Guinea pig 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5CT 2 37 Guinea pig 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
25107520 194372 0 UNDEFINED 70 3 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 None
CHEMBL494709 194372 0 UNDEFINED 70 3 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 None
1809 6922 32 3H-5HT -12 37 Mouse 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -12 37 Mouse 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -12 37 Mouse 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
5 6927 72 3H-5HT 3 53 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT 3 53 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT 3 53 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT 3 53 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-5HT 1 31 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT 1 31 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT 1 31 Guinea pig 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
4106 9280 22 3H-LSD -2 33 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-LSD -2 33 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-LSD -2 33 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-LSD -2 33 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
2105 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
2105 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-5HT -1 32 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
4106 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
4106 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 125I-LSD -2 33 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
23643663 99619 0 UNDEFINED 13 3 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243744 99619 0 UNDEFINED 13 3 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
1809 6922 32 3H-5HT -2 37 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -2 37 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -2 37 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-5HT -12 37 Mouse 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -12 37 Mouse 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -12 37 Mouse 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
115237 62359 119 3H-5HT -5 54 Mouse 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-5HT -5 54 Mouse 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
1238 209953 24 3H-LSD 1 16 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL64249 209953 24 3H-LSD 1 16 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
5 6927 72 3H-5CT 3 53 Guinea pig 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5CT 3 53 Guinea pig 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5CT 3 53 Guinea pig 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5CT 3 53 Guinea pig 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
2389 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2389 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -7 66 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -5 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-5CT 1 31 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5CT 1 31 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5CT 1 31 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
133 9274 52 3H-MESULERGINE -15 43 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-MESULERGINE -15 43 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-MESULERGINE -15 43 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-MESULERGINE -15 43 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-MESULERGINE -15 43 Guinea pig 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2389 10104 118 3H-5HT -4 66 Mouse 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-5HT -4 66 Mouse 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-5HT -4 66 Mouse 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-5HT -4 66 Mouse 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-5HT -4 66 Mouse 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
4106 9280 22 3H-LSD -4 33 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-LSD -4 33 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-LSD -4 33 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-LSD -4 33 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
107 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
107 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 125I-LSD -1 31 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
103 10925 61 3H-LSD -2 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-LSD -2 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-LSD -2 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-LSD -2 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-LSD -2 53 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -5 53 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
242 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
206 9271 16 3H-MESULERGINE -6 25 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-MESULERGINE -6 25 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-MESULERGINE -6 25 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
133 9274 52 3H-MESULERGINE -16 43 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-MESULERGINE -16 43 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-MESULERGINE -16 43 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-MESULERGINE -16 43 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-MESULERGINE -16 43 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
4106 9280 22 3H-5HT -30 33 Guinea pig 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -30 33 Guinea pig 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -30 33 Guinea pig 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -30 33 Guinea pig 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
2470 10425 50 3H-5HT -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
2470 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
103 10925 61 3H-5HT -8 53 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-5HT -8 53 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-5HT -8 53 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-5HT -8 53 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-5HT -8 53 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
242 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
242 7258 124 [3H]-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 [3H]-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 [3H]-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 [3H]-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 [3H]-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
31101 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
31101 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 125I-LSD -25 35 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
None 222831 0 3H-5CT -67 8 Guinea pig 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 339 4 3 3 1.9 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
135 9310 43 3H-5HT -21 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
135 9310 43 3H-LSD -50 56 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -21 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-LSD -50 56 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -21 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-LSD -50 56 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -21 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-LSD -50 56 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -21 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-LSD -50 56 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
135398745 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2470 10425 50 3H-5HT -3019 58 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -3019 58 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -3019 58 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -3019 58 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -3019 58 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
2543 10479 68 3H-MESULERGINE -44 32 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-MESULERGINE -44 32 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-MESULERGINE -44 32 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-MESULERGINE -44 32 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-MESULERGINE -44 32 Guinea pig 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
100 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
681 8247 72 3H-5HT -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
681 8247 72 3H-LSD -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 3H-5HT -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 3H-LSD -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 3H-5HT -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 3H-LSD -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 3H-5HT -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 3H-LSD -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 3H-5HT -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 3H-LSD -354 38 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
1209 8439 75 3H-5HT -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
1209 8439 75 3H-LSD -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
203 8439 75 3H-5HT -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
203 8439 75 3H-LSD -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
3386 8439 75 3H-5HT -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
3386 8439 75 3H-LSD -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
CHEMBL41 8439 75 3H-5HT -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
CHEMBL41 8439 75 3H-LSD -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
DB00472 8439 75 3H-5HT -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
DB00472 8439 75 3H-LSD -186 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
1204 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1204 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1247 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1247 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1375 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1375 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
774 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
774 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
CHEMBL90 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
CHEMBL90 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
DB05381 8713 119 3H-5HT -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
DB05381 8713 119 3H-LSD -616 25 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
12575 8769 30 3H-5HT -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
12575 8769 30 3H-LSD -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
54459 8769 30 3H-5HT -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
54459 8769 30 3H-LSD -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
CHEMBL10316 8769 30 3H-5HT -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
CHEMBL10316 8769 30 3H-LSD -660 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
1427 8794 54 3H-5HT -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
1427 8794 54 3H-LSD -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
357 8794 54 3H-5HT -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
357 8794 54 3H-LSD -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
3696 8794 54 3H-5HT -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
3696 8794 54 3H-LSD -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
CHEMBL11 8794 54 3H-5HT -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
CHEMBL11 8794 54 3H-LSD -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
DB00458 8794 54 3H-5HT -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
DB00458 8794 54 3H-LSD -97 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
1357 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 3H-5HT -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 3H-LSD -3311 9 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
484 9633 51 3H-5HT -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
484 9633 51 3H-LSD -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 3H-5HT -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 3H-LSD -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 3H-5HT -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 3H-LSD -7 35 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
102484 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
102484 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
2149 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
2149 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
3396 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
3396 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
4581 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
4581 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
CHEMBL53929 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
CHEMBL53929 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
DB13251 9681 50 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
DB13251 9681 50 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.4 NCC(c1ccc(cc1)O)O None
2176 9901 68 3H-5HT -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2176 9901 68 3H-LSD -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-5HT -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-LSD -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-5HT -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-LSD -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-5HT -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-LSD -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-5HT -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-LSD -6165 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
173 10036 95 3H-5HT -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
173 10036 95 3H-LSD -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
5011 10036 95 3H-5HT -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
5011 10036 95 3H-LSD -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
CHEMBL18772 10036 95 3H-5HT -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
CHEMBL18772 10036 95 3H-LSD -11 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
189 10265 39 3H-5CT -416 17 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
5163 10265 39 3H-5CT -416 17 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
CHEMBL297784 10265 39 3H-5CT -416 17 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
130 10273 47 35S-GTPGammaS -275 13 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
3378093 10273 47 35S-GTPGammaS -275 13 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL281350 10273 47 35S-GTPGammaS -275 13 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
108182 10903 22 3H-5HT -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
108182 10903 22 3H-LSD -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
245 10903 22 3H-5HT -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
245 10903 22 3H-LSD -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
CHEMBL18041 10903 22 3H-5HT -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
CHEMBL18041 10903 22 3H-LSD -2 17 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
671690 33870 35 3H-5HT 2 10 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 313 2 0 3 3.8 CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 None
671690 33870 35 3H-LSD 2 10 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 313 2 0 3 3.8 CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 None
CHEMBL1365455 33870 35 3H-5HT 2 10 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 313 2 0 3 3.8 CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 None
CHEMBL1365455 33870 35 3H-LSD 2 10 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 313 2 0 3 3.8 CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 None
4595 183494 106 3H-5HT -18 14 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
4595 183494 106 3H-LSD -18 14 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 183494 106 3H-5HT -18 14 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 183494 106 3H-LSD -18 14 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
2771 201796 74 3H-5HT -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
2771 201796 74 3H-LSD -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL1200781 201796 74 3H-5HT -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL1200781 201796 74 3H-LSD -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL549 201796 74 3H-5HT -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL549 201796 74 3H-LSD -12 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
54841 209906 52 3H-5HT -1 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 3H-5HT -1 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
2995 211184 53 3H-LSD -141 23 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
2995 211184 53 3H-5HT -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
2995 211184 53 3H-LSD -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL1696 211184 53 3H-LSD -141 23 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL1696 211184 53 3H-5HT -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL1696 211184 53 3H-LSD -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL72 211184 53 3H-LSD -141 23 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL72 211184 53 3H-5HT -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL72 211184 53 3H-LSD -141 23 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
3337 213146 27 3H-5HT -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
3337 213146 27 3H-LSD -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-5HT -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-LSD -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-5HT -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-LSD -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-5HT -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-LSD -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-5HT -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-LSD -151 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
None 222750 0 125I-LSD -616 15 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
None 222750 0 3H-5HT -616 15 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
None 222750 0 3H-LSD -616 15 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
86287410 222751 0 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 2 1 4 2.3 CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C None
86287410 222751 0 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 2 1 4 2.3 CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C None
None 222752 0 3H-5HT -4 2 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 336 1 2 4 1.9 CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl None
None 222752 0 3H-LSD -4 2 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 336 1 2 4 1.9 CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl None
None 222755 0 3H-5HT - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 298 2 1 4 1.9 CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C None
None 222755 0 3H-LSD - 1 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 298 2 1 4 1.9 CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C None
3035240 222757 0 3H-5HT -11 5 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 359 3 2 4 2.6 COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl None
3035240 222757 0 3H-LSD -11 5 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 359 3 2 4 2.6 COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl None
None 222790 0 3H-5HT -43 6 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 367 2 1 6 2.4 CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl None
None 222790 0 3H-LSD -43 6 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 367 2 1 6 2.4 CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl None
1576 223105 0 3H-LSD -1 40 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 163 3 1 2 1.5 CC(C(=O)C1=CC=CC=C1)NC None
None 223229 0 Functional -66 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
None 223229 0 UNDEFINED -66 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
3075702 224111 0 3H-LSD -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
1028 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 3H-5HT -1862 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
135398737 7745 93 3H-5CT -13 90 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5CT -13 90 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5CT -13 90 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5CT -13 90 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5CT -13 90 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
132 8058 13 3H-5HT -281838 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 287 5 3 4 2.2 N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 None
155346 8058 13 3H-5HT -281838 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 287 5 3 4 2.2 N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 None
CHEMBL378501 8058 13 3H-5HT -281838 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 287 5 3 4 2.2 N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 None
681 8247 72 3H-5HT -1995 38 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
681 8247 72 3H-5HT -354 38 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 3H-5HT -1995 38 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 3H-5HT -354 38 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 3H-5HT -1995 38 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 3H-5HT -354 38 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 3H-5HT -1995 38 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 3H-5HT -354 38 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 3H-5HT -1995 38 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 3H-5HT -354 38 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
107780 8625 54 3H-LSD -2691 18 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
14 8625 54 3H-LSD -2691 18 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL15928 8625 54 3H-LSD -2691 18 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
1204 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1204 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1247 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1247 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1375 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1375 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
774 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
774 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
CHEMBL90 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
CHEMBL90 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
DB05381 8713 119 3H-5HT -1949 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
DB05381 8713 119 3H-5HT -616 25 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 111 2 2 2 -0.1 NCCc1cnc[nH]1 None
1782 9296 84 3H-5HT -676 23 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 299 7 2 4 2.0 CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC None
241 9296 84 3H-5HT -676 23 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 299 7 2 4 2.0 CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC None
4168 9296 84 3H-5HT -676 23 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 299 7 2 4 2.0 CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC None
CHEMBL86 9296 84 3H-5HT -676 23 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 299 7 2 4 2.0 CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC None
DB01233 9296 84 3H-5HT -676 23 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 299 7 2 4 2.0 CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC None
135 9310 43 3H-5HT -50 56 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -50 56 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -50 56 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -50 56 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -50 56 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
484 9633 51 3H-5HT -100 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 3H-5HT -100 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 3H-5HT -100 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
127 9900 52 3H-5CT -22908 15 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C None
688095 9900 52 3H-5CT -22908 15 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL117405 9900 52 3H-5CT -22908 15 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C None
2176 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2176 9901 68 3H-MESULERGINE -6165 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-MESULERGINE -6165 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-MESULERGINE -6165 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-MESULERGINE -6165 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-MESULERGINE -6165 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2274 9947 58 3H-5CT -4786 31 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4917 9947 58 3H-5CT -4786 31 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
7279 9947 58 3H-5CT -4786 31 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL728 9947 58 3H-5CT -4786 31 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00433 9947 58 3H-5CT -4786 31 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
243 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
128563 10237 33 3H-LSD -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
1666 10237 33 3H-LSD -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
CHEMBL445332 10237 33 3H-LSD -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
DB12327 10237 33 3H-LSD -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
28 10269 46 3H-5CT -6025 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
3292447 10269 46 3H-5CT -6025 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL20963 10269 46 3H-5CT -6025 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
6917970 10463 61 3H-LSD -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
8370 10463 61 3H-LSD -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
CHEMBL487387 10463 61 3H-LSD -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
214 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-5CT -4570 30 Guinea pig 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
108182 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
245 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
CHEMBL18041 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
2662 18156 131 3H-LSD -41 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
CHEMBL118 18156 131 3H-LSD -41 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
5090 22333 106 3H-LSD -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
CHEMBL122 22333 106 3H-LSD -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
10297 33885 30 3H-LSD -38 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
CHEMBL136560 33885 30 3H-LSD -38 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
156391 53574 99 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL1200806 53574 99 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL154 53574 99 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
2244 101008 100 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
CHEMBL25 101008 100 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
3663 106743 83 3H-LSD -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
CHEMBL286494 106743 83 3H-LSD -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
446220 140299 14 3H-LSD -1778 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
CHEMBL370805 140299 14 3H-LSD -1778 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
1615 174570 24 3H-LSD -26 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
CHEMBL43048 174570 24 3H-LSD -26 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
5280343 195054 124 3H-LSD -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL1520590 195054 124 3H-LSD -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL50 195054 124 3H-LSD -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
3672 199312 136 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
CHEMBL521 199312 136 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
4495 203314 92 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
CHEMBL56367 203314 92 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
54677470 207330 115 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL1256873 207330 115 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL599 207330 115 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
162265 209053 22 3H-LSD -16 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 3H-LSD -16 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 3H-LSD -16 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
5281600 209804 92 3H-LSD -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
CHEMBL63354 209804 92 3H-LSD -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
5656 209845 87 3H-5HT -79 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 3H-5HT -79 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
1973 210262 15 3H-LSD -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 210262 15 3H-LSD -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 210262 15 3H-LSD -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
3821 211497 17 3H-LSD -1 18 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 237 2 1 2 2.9 CNC1(c2ccccc2Cl)CCCCC1=O None
CHEMBL742 211497 17 3H-LSD -1 18 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 237 2 1 2 2.9 CNC1(c2ccccc2Cl)CCCCC1=O None
4158 212120 21 3H-LSD -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL1722 212120 21 3H-LSD -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL796 212120 21 3H-LSD -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
4054 212280 72 3H-LSD -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL1699 212280 72 3H-LSD -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL807 212280 72 3H-LSD -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
119607 212982 113 3H-LSD -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
CHEMBL865 212982 113 3H-LSD -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
3337 213146 27 3H-LSD -169 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-LSD -169 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-LSD -169 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-LSD -169 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-LSD -169 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
57174031 222719 0 3H-5HT -1778 20 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 2 1 3 3.0 CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 None
None 222772 0 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 329 2 0 4 3.6 CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl None
104911 222798 0 3H-LSD -41686 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
25137849 222958 0 3H-LSD -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-LSD -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
None 222993 0 3H-5-CABOXAMIDOTRYPTAMINE -891 14 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 438 5 1 4 4.8 C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 None
None 223090 0 3H-LSD -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 240 7 4 6 -0.8 C(C(C(=O)O)N)SSCC(C(=O)O)N None
None 223091 0 3H-LSD -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 149 4 2 3 0.2 CSCCC(C(=O)O)N None
None 223092 0 3H-LSD -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 135 3 3 3 -0.3 C(CS)C(C(=O)O)N None
None 223093 0 3H-LSD -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 121 2 3 3 -0.7 C(C(C(=O)O)N)S None
None 223094 0 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 117 0 1 3 -0.0 C1CSC(=O)C1N None
None 223095 0 3H-LSD -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 3 3 3 -1.4 C(C(C(=O)O)N)S(=O)O None
None 223096 0 3H-LSD -1 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 3 3 4 -1.7 C(C(C(=O)O)N)S(=O)(=O)O None
None 223097 0 3H-LSD -1 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 4 3 4 -1.3 C(CS(=O)(=O)O)C(C(=O)O)N None
None 223106 0 3H-LSD -16 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 536 11 1 4 9.0 CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C None
4978 223107 0 3H-LSD -7 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 1 7 9 4.3 CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O None
None 223108 0 3H-LSD -3 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 464 4 8 12 -0.6 C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O None
None 223109 0 3H-LSD -281 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 610 6 10 16 -1.7 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O None
None 223110 0 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 448 3 7 11 0.4 CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O None
135269 223168 0 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 222 5 1 3 2.5 CCCCC(=O)OC1=CC=CC=C1C(=O)O None
23681059 223169 0 3H-LSD -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O None
5018304 223170 0 3H-LSD -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 317 4 1 3 0.0 C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] None
84003 223171 0 3H-LSD -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 376 6 5 7 -0.0 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O None
123619 223172 0 3H-LSD -1412 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 358 3 0 4 4.2 CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl None
119828 223173 0 3H-LSD -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 370 5 1 5 3.5 CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C None
None 223174 0 3H-LSD -7 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 517 8 2 5 5.2 CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C None
None 223268 0 3H-LSD -4570 26 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 347 6 0 3 5.0 CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 None
11957566 6972 25 3H-5HT -301 8 Rat 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cc(cc2)O)CCC None
1219 6972 25 3H-5HT -301 8 Rat 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cc(cc2)O)CCC None
3296 6972 25 3H-5HT -301 8 Rat 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cc(cc2)O)CCC None
950 6972 25 3H-5HT -301 8 Rat 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cc(cc2)O)CCC None
CHEMBL285755 6972 25 3H-5HT -301 8 Rat 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)cc(cc2)O)CCC None
135398745 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -34 65 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135 9310 43 3H-5CT -138 56 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5CT -138 56 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5CT -138 56 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5CT -138 56 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5CT -138 56 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2470 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
265 6916 0 3H-5CT -4 3 Guinea pig 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
89576 6916 0 3H-5CT -4 3 Guinea pig 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
CHEMBL1288652 6916 0 3H-5CT -4 3 Guinea pig 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
179 7188 115 3H-LSD -9 50 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 3H-LSD -9 50 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 3H-LSD -9 50 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 3H-LSD -9 50 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 3H-LSD -9 50 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2470 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -1258 58 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
1353 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
135 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
3294 8787 111 3H-MESULERGINE -41 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-MESULERGINE -41 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-MESULERGINE -41 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-MESULERGINE -41 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-MESULERGINE -41 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
135 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 125I-LSD -50 56 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1353 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1353 8692 93 3H-5HT -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5HT -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5HT -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5HT -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5HT -263 85 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
119570 9933 96 3H-LSD -93 39 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 3H-LSD -93 39 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 3H-LSD -93 39 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 3H-LSD -93 39 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 3H-LSD -93 39 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
103 10925 61 3H-LSD -6 53 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-LSD -6 53 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-LSD -6 53 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-LSD -6 53 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-LSD -6 53 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
11954259 222758 0 3H-LSD -39 43 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
134 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
134 9292 24 3H-5HT -9 67 Mouse 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
134 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -9 67 Mouse 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -9 67 Mouse 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -9 67 Mouse 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -9 67 Mouse 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
206 9271 16 3H-MESULERGINE -15 25 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-MESULERGINE -15 25 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-MESULERGINE -15 25 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
134 9292 24 3H-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-LSD -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
21830793 98610 10 3H-8-OH-DPAT -85 46 Bovine 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 98610 10 3H-8-OH-DPAT -85 46 Bovine 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
135398745 9688 112 3H-5HT -61 65 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5HT -61 65 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5HT -61 65 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5HT -61 65 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
180 7189 56 125I-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 125I-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 125I-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 125I-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 125I-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
277 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
277 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5HT -63 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
1346 6871 117 3H-5HT -147 9 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
280 6871 117 3H-5HT -147 9 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
9899402 6871 117 3H-5HT -147 9 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
CHEMBL9666 6871 117 3H-5HT -147 9 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
180 7189 56 3H-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 3H-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 3H-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 3H-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 3H-LSD -125 40 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
31101 7516 40 3H-5HT -181 35 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-5HT -181 35 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-5HT -181 35 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-5HT -181 35 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-5HT -181 35 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
277 8083 62 3H-5CT -301 50 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5CT -301 50 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5CT -301 50 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5CT -301 50 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5CT -301 50 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
3652 10869 79 3H-5CT -6 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
57 10869 79 3H-5CT -6 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
60809 10869 79 3H-5CT -6 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
CHEMBL21536 10869 79 3H-5CT -6 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
DB15357 10869 79 3H-5CT -6 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
1574 6869 60 3H-5HT -13 21 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
218 6869 60 3H-5HT -13 21 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
CHEMBL266591 6869 60 3H-5HT -13 21 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
2398 7741 62 3H-5HT -15 29 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
2801 7741 62 3H-5HT -15 29 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
701 7741 62 3H-5HT -15 29 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
CHEMBL415 7741 62 3H-5HT -15 29 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
DB01242 7741 62 3H-5HT -15 29 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
11954224 222732 0 3H- LSD -18197 59 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
11954224 222732 0 3H-LSD -18197 59 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
134 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
135398737 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
122 8219 9 3H-5CT -1 11 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
156314 8219 9 3H-5CT -1 11 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL1332062 8219 9 3H-5CT -1 11 Guinea pig 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
134 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -18 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
135398737 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 125I-LSD -7 90 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
24768524 99977 0 UNDEFINED -4 3 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 423 8 1 3 4.7 O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21 None
CHEMBL244577 99977 0 UNDEFINED -4 3 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 423 8 1 3 4.7 O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21 None
1613 9127 53 3H-5HT -14 44 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-5HT -14 44 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-5HT -14 44 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-5HT -14 44 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-5HT -14 44 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
2337 10030 77 3H-LSD -15 62 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -15 62 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -15 62 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -15 62 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -15 62 Rat 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
1524 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5HT -501 51 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
1220 6975 55 3H-5CT -51 44 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5CT -51 44 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5CT -51 44 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5CT -51 44 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
179 7188 115 3H-5CT -9 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 3H-5CT -9 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 3H-5CT -9 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 3H-5CT -9 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 3H-5CT -9 50 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
11954224 222732 0 3H-5CT -1174 59 Guinea pig 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
242 7258 124 3H-LSD -14 51 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -14 51 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -14 51 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -14 51 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -14 51 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
135409468 8816 69 3H-LSD -5 39 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
333 8816 69 3H-LSD -5 39 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
CHEMBL845 8816 69 3H-LSD -5 39 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
191 7191 98 3H-5CT -380 29 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 3H-5CT -380 29 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 3H-5CT -380 29 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 3H-5CT -380 29 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 3H-5CT -380 29 Guinea pig 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
214 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-5CT -4570 30 Guinea pig 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
135398737 7745 93 3H-5CT -34 90 Guinea pig 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5CT -34 90 Guinea pig 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5CT -34 90 Guinea pig 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5CT -34 90 Guinea pig 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5CT -34 90 Guinea pig 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1150 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
25107581 199410 0 UNDEFINED -14 3 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 505 12 1 7 3.7 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
CHEMBL521687 199410 0 UNDEFINED -14 3 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 505 12 1 7 3.7 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
1150 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5HT -6 25 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
5074 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
11954259 222758 0 3H-LSD -51 43 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
5074 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5HT -36 30 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
206 9271 16 3H-5CT -15 25 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5CT -15 25 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5CT -15 25 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
None 222722 0 3H-5CT -17 11 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
11954259 222758 0 3H-LSD -51 43 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
2181 9902 46 3H-5HT -125 34 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 3H-5HT -125 34 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 3H-5HT -125 34 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 3H-5HT -125 34 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 3H-5HT -125 34 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
None 222717 0 3H-5HT -2511 21 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 583 4 3 6 2.1 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C None
None 222717 0 UNDEFINED -2511 21 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 583 4 3 6 2.1 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C None
2402 10143 62 3H-LSD -5 24 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 10143 62 3H-LSD -5 24 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 10143 62 3H-LSD -5 24 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 10143 62 3H-LSD -5 24 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 10143 62 3H-LSD -5 24 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
135398745 9688 112 3H-LSD -34 65 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -34 65 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -34 65 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -34 65 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745 9688 112 3H-LSD -95 65 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
133 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
133 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 125I-LSD -16 43 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1150 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
1150 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5HT 1 25 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
7153 104796 77 3H-LSD -8 33 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 3H-LSD -8 33 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
2337 10030 77 3H-LSD -28 62 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
134 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
11954224 222732 0 125I-LSD -245 59 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
134 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -18 67 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
11954224 222732 0 125I-LSD -245 59 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
2105 9828 37 3H-5CT -2 32 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-5CT -2 32 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-5CT -2 32 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-5CT -2 32 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-5CT -2 32 Guinea pig 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
135398737 7745 93 3H-LSD -13 90 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1613 9127 53 125I-LSD -14 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 125I-LSD -14 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 125I-LSD -14 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 125I-LSD -14 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 125I-LSD -14 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
None 223158 0 3H-LSD -199 11 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 243 3 1 4 2.7 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N None
2337 10030 77 3H-LSD -28 62 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
213 10625 55 3H-LSD -9 43 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 10625 55 3H-LSD -9 43 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 10625 55 3H-LSD -9 43 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 10625 55 3H-LSD -9 43 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 10625 55 3H-LSD -9 43 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
11675876 194293 0 UNDEFINED -54 3 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 8 0 4 3.9 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
CHEMBL494316 194293 0 UNDEFINED -54 3 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 8 0 4 3.9 COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
135398737 7745 93 3H-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 [3H]-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 [3H]-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 [3H]-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 [3H]-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 [3H]-5-CT -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
206 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
1342 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
206 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -10 25 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
283 9904 57 3H-5CT -28 12 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
4847 9904 57 3H-5CT -28 12 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
CHEMBL18331 9904 57 3H-5CT -28 12 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
1342 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -13 19 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
1588 9105 27 3H-5CT -21 44 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-5CT -21 44 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-5CT -21 44 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-5CT -21 44 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-5CT -21 44 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2337 10030 77 3H-LSD -28 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
135398745 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
191 7191 98 3H-5CT -380 29 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 3H-5CT -380 29 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 3H-5CT -380 29 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 3H-5CT -380 29 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 3H-5CT -380 29 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
1150 10650 121 3H-5CT -1 25 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5CT -1 25 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5CT -1 25 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5CT -1 25 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
135398737 7745 93 3H-LSD -7 90 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -7 90 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -7 90 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -7 90 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -7 90 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
10257 7525 31 3H-5HT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
144 7525 31 3H-5HT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
CHEMBL416526 7525 31 3H-5HT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
DB01445 7525 31 3H-5HT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
2726 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
5074 10105 80 3H-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
2470 10425 50 UNDEFINED -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 UNDEFINED -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 UNDEFINED -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 UNDEFINED -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 UNDEFINED -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5074 10105 80 3H-5CT -61 30 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5CT -61 30 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5CT -61 30 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5CT -61 30 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
6852400 222716 0 3H-5CT -1023 22 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
73759726 222716 0 3H-5CT -1023 22 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
12016890 197555 6 3H-5HT -3235 12 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 318 4 1 3 2.6 NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 None
CHEMBL5183389 197555 6 3H-5HT -3235 12 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 318 4 1 3 2.6 NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 None
2274 9947 58 3H-LSD -93 31 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4917 9947 58 3H-LSD -93 31 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
7279 9947 58 3H-LSD -93 31 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL728 9947 58 3H-LSD -93 31 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00433 9947 58 3H-LSD -93 31 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
1621 9207 17 3H-5HT -34 44 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 3H-5HT -34 44 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 3H-5HT -34 44 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 3H-5HT -34 44 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 3H-5HT -34 44 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
1524 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
1220 6975 55 3H-5HT -75 44 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -75 44 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -75 44 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -75 44 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
133 9274 52 3H-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
133 9274 52 125I-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 125I-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 125I-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 125I-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 125I-LSD -16 43 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
5 6927 72 3H-5-HT -3 53 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5-HT -3 53 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5-HT -3 53 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5-HT -3 53 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
17676 13844 29 3H-LSD 30 3 Rat 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 None
5281082 13844 29 3H-LSD 30 3 Rat 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 None
CHEMBL1085 13844 29 3H-LSD 30 3 Rat 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 None
1238 209953 24 3H-5CT -13 16 Guinea pig 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL64249 209953 24 3H-5CT -13 16 Guinea pig 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
115237 62359 119 3H-LSD -20 54 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-LSD -20 54 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
2389 10104 118 3H-LSD -8 66 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
10090005 222765 0 3H-LSD -3 11 Rat 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 361 1 0 3 4.4 CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42 None
1588 9105 27 3H-5CT -21 44 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-5CT -21 44 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-5CT -21 44 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-5CT -21 44 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-5CT -21 44 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2105 9828 37 3H-5CT -2 32 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-5CT -2 32 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-5CT -2 32 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-5CT -2 32 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-5CT -2 32 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
2470 10425 50 3H-5HT -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -389 58 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
145 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
206 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
145 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 125I-LSD -4 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
25137849 222958 0 3H-LSD -1 40 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-LSD -1 40 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
1524 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 125I-LSD -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
135398745 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5-CT -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745 9688 112 3H-LSD -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2726 7706 68 3H-LSD -13 72 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
135398737 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-5HT -9 90 Mouse 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -9 90 Mouse 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -9 90 Mouse 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -9 90 Mouse 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -9 90 Mouse 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
206 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -6 25 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
10257 7525 31 3H-5CT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
144 7525 31 3H-5CT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
CHEMBL416526 7525 31 3H-5CT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
DB01445 7525 31 3H-5CT -13 19 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
3294 8787 111 3H-LSD -21 44 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-LSD -21 44 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-LSD -21 44 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-LSD -21 44 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-LSD -21 44 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
5074 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
5074 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 125I-LSD -36 30 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
2470 10425 50 3H-5CT -3019 58 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5CT -3019 58 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5CT -3019 58 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5CT -3019 58 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5CT -3019 58 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
25107650 194064 0 UNDEFINED -23 3 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 407 10 1 3 4.8 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
CHEMBL492872 194064 0 UNDEFINED -23 3 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 407 10 1 3 4.8 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
62865 8057 0 3H-5HT -7 15 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
746 8057 0 3H-5HT -7 15 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
84 8057 0 3H-5HT -7 15 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
CHEMBL2104153 8057 0 3H-5HT -7 15 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
DB09000 8057 0 3H-5HT -7 15 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
163839 9729 0 3H-LSD -1 6 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
268 9729 0 3H-LSD -1 6 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
CHEMBL55171 9729 0 3H-LSD -1 6 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
25107649 194036 0 UNDEFINED -1 3 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 411 10 1 4 4.4 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
CHEMBL492691 194036 0 UNDEFINED -1 3 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 411 10 1 4 4.4 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
134 9292 24 3H-5CT -37 67 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5CT -37 67 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5CT -37 67 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5CT -37 67 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5CT -37 67 Guinea pig 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
209 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
25107519 194448 0 UNDEFINED -17 3 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 10 1 4 3.7 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
CHEMBL495120 194448 0 UNDEFINED -17 3 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 10 1 4 3.7 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1 None
202 8290 77 3H-5HT -1 33 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 3H-5HT -1 33 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 3H-5HT -1 33 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 3H-5HT -1 33 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 3H-5HT -1 33 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
209 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
209 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-LSD -31 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
25137849 222958 0 3H-LSD -1 40 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-LSD -1 40 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
115 10563 80 3H-5HT -8 27 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
4296 10563 80 3H-5HT -8 27 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
CHEMBL274866 10563 80 3H-5HT -8 27 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
1353 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1346 6871 117 125I-LSD -147 9 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
280 6871 117 125I-LSD -147 9 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
9899402 6871 117 125I-LSD -147 9 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
CHEMBL9666 6871 117 125I-LSD -147 9 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 None
135398745 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
5 6927 72 3H-5HT -5 53 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -5 53 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -5 53 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -5 53 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
206 9271 16 3H-5HT -16 25 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -16 25 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -16 25 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
209 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-LSD -25 23 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
5074 10105 80 3H-MESULERGINE -36 30 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-MESULERGINE -36 30 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-MESULERGINE -36 30 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-MESULERGINE -36 30 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
2543 10479 68 3H-MESULERGINE -44 32 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-MESULERGINE -44 32 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-MESULERGINE -44 32 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-MESULERGINE -44 32 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-MESULERGINE -44 32 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
24768520 99782 0 UNDEFINED -1 4 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL244161 99782 0 UNDEFINED -1 4 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
135398745 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-LSD -95 65 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2176 9901 68 3H-5HT -6165 27 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-5HT -6165 27 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-5HT -6165 27 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-5HT -6165 27 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-5HT -6165 27 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2543 10479 68 3H-5HT -44 32 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -44 32 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -44 32 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -44 32 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -44 32 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1220 6975 55 3H-5HT -199 44 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -199 44 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -199 44 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -199 44 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
2543 10479 68 3H-5HT -44 32 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -44 32 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -44 32 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -44 32 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -44 32 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1220 6975 55 3H-5CT -208 44 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5CT -208 44 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5CT -208 44 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5CT -208 44 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7153 104796 77 UNDEFINED -14 33 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 UNDEFINED -14 33 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
7153 104796 77 3H-5HT -14 33 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 3H-5HT -14 33 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
265 6916 0 3H-5CT -4 3 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
89576 6916 0 3H-5CT -4 3 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
CHEMBL1288652 6916 0 3H-5CT -4 3 Guinea pig 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 266 5 2 2 3.2 NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2 None
1353 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1353 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -120 85 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1524 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5HT -169 51 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
1816 9318 102 3H-5HT -165 18 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
4205 9318 102 3H-5HT -165 18 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
7241 9318 102 3H-5HT -165 18 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
CHEMBL654 9318 102 3H-5HT -165 18 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
DB00370 9318 102 3H-5HT -165 18 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
1830 9368 44 3H-LSD -46 28 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 3H-LSD -46 28 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 3H-LSD -46 28 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 3H-LSD -46 28 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 3H-LSD -46 28 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
2726 7706 68 3H-LSD -13 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
None 223104 0 3H-LSD -3 40 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 149 2 1 2 1.2 CC(C(=O)C1=CC=CC=C1)N None
15897 9637 0 3H-LSD -12 36 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 3H-LSD -12 36 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 3H-LSD -12 36 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
24768525 150699 0 UNDEFINED -7 3 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 406 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21 None
CHEMBL390213 150699 0 UNDEFINED -7 3 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 406 8 1 4 4.0 O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21 None
2435 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2435 10362 83 3H-5HT -54 48 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2435 10362 83 3H-LSD -54 48 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-5HT -54 48 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-LSD -54 48 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-5HT -54 48 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-LSD -54 48 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-5HT -54 48 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-LSD -54 48 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-5HT -54 48 Mouse 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-LSD -54 48 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
16106 124924 34 3H-LSD -3 11 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 291 0 0 3 2.9 CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 None
CHEMBL340801 124924 34 3H-LSD -3 11 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 291 0 0 3 2.9 CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 None
2435 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-LSD -36 48 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
24768518 99614 0 UNDEFINED -46 3 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 461 11 1 3 5.9 CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243743 99614 0 UNDEFINED -46 3 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 461 11 1 3 5.9 CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
102 10899 48 3H-5HT -851 49 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-5HT -851 49 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-5HT -851 49 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-5HT -851 49 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-5HT -851 49 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
214 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1524 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5CT -1023 51 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
2337 10030 77 3H-5HT -32 62 Mouse 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-5HT -32 62 Mouse 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-5HT -32 62 Mouse 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-5HT -32 62 Mouse 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-5HT -32 62 Mouse 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
214 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-LSD -52 30 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
25107717 194329 1 UNDEFINED -6 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 420 10 1 5 3.6 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
CHEMBL494512 194329 1 UNDEFINED -6 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 420 10 1 5 3.6 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
2389 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2389 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
4106 9280 22 3H-5CT -4 33 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5CT -4 33 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5CT -4 33 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5CT -4 33 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
2389 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
4106 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
4106 9280 22 3H-5CT -30 33 Guinea pig 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
4106 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5CT -30 33 Guinea pig 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5CT -30 33 Guinea pig 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5CT -30 33 Guinea pig 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -4 33 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
None 223057 0 3H-LSD -42 12 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 426 6 0 6 3.4 C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54 None
25107648 194002 0 UNDEFINED 25 3 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 None
CHEMBL492480 194002 0 UNDEFINED 25 3 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 None
145 6928 49 3H-LSD -2 30 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 3H-LSD -2 30 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 3H-LSD -2 30 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 3H-LSD -2 30 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
277 8083 62 3H-LSD -63 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-LSD -63 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-LSD -63 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-LSD -63 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-LSD -63 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
134 9292 24 3H-LSD -24 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-LSD -24 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-LSD -24 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-LSD -24 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-LSD -24 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
2435 10362 83 3H-LSD -36 48 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-LSD -36 48 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-LSD -36 48 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-LSD -36 48 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-LSD -36 48 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
None 222722 0 3H-5CT -17 11 Guinea pig 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
1577 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
2537 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5355 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5501 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
643497 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
688272 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
958 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
960 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL196677 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL26 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL267044 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB00391 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB16021 10475 110 3H-5HT -208 20 Rat 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
1830 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
173 10036 95 3H-LSD -34 23 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
5011 10036 95 3H-LSD -34 23 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
CHEMBL18772 10036 95 3H-LSD -34 23 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 213 1 1 3 1.6 N1CCN(CC1)c1ccc2c(n1)cccc2 None
1830 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 3H-LSD -30 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
2337 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-LSD -28 62 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
25107517 194035 0 UNDEFINED -1 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 421 8 0 4 4.0 COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
CHEMBL492690 194035 0 UNDEFINED -1 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 421 8 0 4 4.0 COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
37459 7533 13 3H-5HT -74 24 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
62 7533 13 3H-5HT -74 24 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
CHEMBL8514 7533 13 3H-5HT -74 24 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
206 9271 16 3H-5CT -10 25 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5CT -10 25 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5CT -10 25 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
133 9274 52 3H-5HT -36 43 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -36 43 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -36 43 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -36 43 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -36 43 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
282 8201 0 3H-5HT -3548 7 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
522609 8201 0 3H-5HT -3548 7 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
135398745 9688 112 3H-5CT -95 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5CT -95 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5CT -95 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5CT -95 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
None 223229 0 3H-5CT -208 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
None 223229 0 UNDEFINED -208 28 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
5074 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
1238 209953 24 3H-5CT -13 16 Guinea pig 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL64249 209953 24 3H-5CT -13 16 Guinea pig 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
1150 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
25107515 194139 0 UNDEFINED -16 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 437 8 0 4 4.7 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
CHEMBL493305 194139 0 UNDEFINED -16 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 437 8 0 4 4.7 CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
1353 8692 93 3H-LSD -263 85 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -263 85 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -263 85 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -263 85 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -263 85 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
5074 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 125I-LSD -36 30 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
1150 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 125I-LSD 1 25 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
1342 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
1342 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 125I-LSD -13 19 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
277 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
1353 8692 93 3H-5CT -3801 85 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5CT -3801 85 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5CT -3801 85 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5CT -3801 85 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5CT -3801 85 Guinea pig 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
24768522 149354 0 UNDEFINED 2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 462 9 2 4 4.5 CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL389110 149354 0 UNDEFINED 2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 462 9 2 4 4.5 CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
277 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5HT -43 50 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
1220 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
25107651 194489 0 UNDEFINED -4 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 412 10 1 5 3.8 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
CHEMBL495321 194489 0 UNDEFINED -4 3 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 412 10 1 5 3.8 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
1220 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
179 7188 115 3H-LSD -9 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 3H-LSD -9 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 3H-LSD -9 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 3H-LSD -9 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 3H-LSD -9 50 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
166535 222749 0 3H-5HT -87 2 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 413 6 1 4 3.4 C1CN(CCC12C(=O)NCN2C3=CC=C(C=C3)F)CCCC(=O)C4=CC=C(C=C4)F None
1220 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1220 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 125I-LSD -75 44 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
2726 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-LSD -13 72 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
7153 104796 77 125I-LSD -14 33 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 125I-LSD -14 33 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
135 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
54477 91428 36 3H-LSD -501 22 Human 4.4 pKi = 4.4 Binding
NoneNone
PDSP KiDatabase 370 6 1 4 2.7 CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC None
CHEMBL22242 91428 36 3H-LSD -501 22 Human 4.4 pKi = 4.4 Binding
NoneNone
PDSP KiDatabase 370 6 1 4 2.7 CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC None
135398745 9688 112 3H-5HT -95 65 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5HT -95 65 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5HT -95 65 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5HT -95 65 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -50 56 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2477 7532 59 125I-LSD -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 125I-LSD -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 125I-LSD -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 125I-LSD -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 125I-LSD -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
1353 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1353 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-LSD -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
242 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
1353 8692 93 3H-5HT -74 85 Mouse 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5HT -74 85 Mouse 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5HT -74 85 Mouse 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5HT -74 85 Mouse 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5HT -74 85 Mouse 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
2477 7532 59 3H-5HT -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 3H-5HT -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 3H-5HT -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 3H-5HT -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 3H-5HT -21 29 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
1220 6975 55 3H-5-HT -208 44 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5-HT -208 44 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5-HT -208 44 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5-HT -208 44 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
25107652 194191 0 UNDEFINED -20 3 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 396 10 1 5 3.1 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
CHEMBL493709 194191 0 UNDEFINED -20 3 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 396 10 1 5 3.1 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
242 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
135398737 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
191 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
135398737 7745 93 3H-5HT -9 90 Mouse 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -9 90 Mouse 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -9 90 Mouse 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -9 90 Mouse 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -9 90 Mouse 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -7 90 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1613 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
134 9292 24 3H-5HT -37 67 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -37 67 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -37 67 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -37 67 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -37 67 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
134 9292 24 3H-5HT -18 67 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -18 67 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -18 67 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -18 67 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -18 67 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
2389 10104 118 3H-5HT -8 66 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-5HT -8 66 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-5HT -8 66 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-5HT -8 66 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-5HT -8 66 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
16351 109507 47 3H-LSD -1 6 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL304902 109507 47 3H-LSD -1 6 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 None
279 8442 26 3H-LSD 1 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 None
49381 8442 26 3H-LSD 1 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 None
CHEMBL63756 8442 26 3H-LSD 1 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 None
2865 10915 73 3H-LSD -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
2105 9828 37 125I-LSD -1 32 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 125I-LSD -1 32 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 125I-LSD -1 32 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 125I-LSD -1 32 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 125I-LSD -1 32 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
5 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
2865 10915 73 3H-5HT -10 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-5HT -10 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-5HT -10 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-5HT -10 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-5HT -10 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
135398737 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
191 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 3H-LSD -19 29 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
1220 6975 55 3H-5CT -51 44 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5CT -51 44 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5CT -51 44 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5CT -51 44 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1353 8692 93 3H-5-CT -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5-CT -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5-CT -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5-CT -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5-CT -263 85 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
2601 10552 33 3H-5CT -20 21 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 3H-5CT -20 21 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 3H-5CT -20 21 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 3H-5CT -20 21 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 3H-5CT -20 21 Guinea pig 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
15897 9637 0 3H-LSD -12 36 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 3H-LSD -12 36 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 3H-LSD -12 36 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
3337 213146 27 3H-LSD -169 40 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-LSD -169 40 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-LSD -169 40 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-LSD -169 40 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-LSD -169 40 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
25108474 199979 0 UNDEFINED -38 3 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 423 8 0 4 4.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
CHEMBL523381 199979 0 UNDEFINED -38 3 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 423 8 0 4 4.6 CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
135398737 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
24768523 150458 0 UNDEFINED -4 2 Rat 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 498 10 2 5 3.9 CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL390015 150458 0 UNDEFINED -4 2 Rat 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 498 10 2 5 3.9 CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
1613 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-LSD -14 44 Rat 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
242 7258 124 3H-5-CT -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-5-CT -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-5-CT -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-5-CT -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-5-CT -15 51 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
5074 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
5074 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5HT -69 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
4106 9280 22 3H-5CT -30 33 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5CT -30 33 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5CT -30 33 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5CT -30 33 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5074 10105 80 3H-5CT -61 30 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-5CT -61 30 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-5CT -61 30 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-5CT -61 30 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
1220 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1220 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -208 44 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
135398737 7745 93 3H-5CT -34 90 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5CT -34 90 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5CT -34 90 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5CT -34 90 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5CT -34 90 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
277 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2470 10425 50 3H-5CT -3019 58 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5CT -3019 58 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5CT -3019 58 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5CT -3019 58 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5CT -3019 58 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
135398737 7745 93 3H-5HT -13 90 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -13 90 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -13 90 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -13 90 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -13 90 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
277 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 125I-LSD -43 50 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
31101 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
31101 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-5HT -25 35 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
133 9274 52 3H-5CT -15 43 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5CT -15 43 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5CT -15 43 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5CT -15 43 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5CT -15 43 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
11954224 222732 0 3H-5CT -1174 59 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
18971832 9196 0 3H-5HT -812 13 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
21 9196 0 3H-5HT -812 13 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
CHEMBL3186179 9196 0 3H-5HT -812 13 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
24768517 99603 0 UNDEFINED 2 3 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 447 10 1 3 5.5 CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243742 99603 0 UNDEFINED 2 3 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 447 10 1 3 5.5 CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
5 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -5 53 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
2865 10915 73 3H-5-CT -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-5-CT -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-5-CT -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-5-CT -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-5-CT -12 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
5 6927 72 3H-5HT -11 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -11 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -11 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -11 53 Mouse 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -3 31 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
11976 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
2389 10104 118 3H-5CT -8 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2389 10104 118 3H-MESULERGINE -7 66 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-5CT -8 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-MESULERGINE -7 66 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-5CT -8 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-MESULERGINE -7 66 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-5CT -8 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-MESULERGINE -7 66 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-5CT -8 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-MESULERGINE -7 66 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5074 10105 80 3H-MESULERGINE -61 30 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
97 10105 80 3H-MESULERGINE -61 30 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
CHEMBL267777 10105 80 3H-MESULERGINE -61 30 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
DB12693 10105 80 3H-MESULERGINE -61 30 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F None
25107578 199835 0 UNDEFINED 4 3 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 408 10 1 4 4.2 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
CHEMBL522343 199835 0 UNDEFINED 4 3 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 408 10 1 4 4.2 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1 None
216239 30567 118 None -9 7 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
Drug Central 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 None
CHEMBL1200485 30567 118 None -9 7 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
Drug Central 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 None
CHEMBL1336 30567 118 None -9 7 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
Drug Central 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 None
66265 100788 15 None -1 19 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL248702 100788 15 None -1 19 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 None
2726 7706 68 None -301 72 Mouse 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None -301 72 Mouse 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None -301 72 Mouse 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None -301 72 Mouse 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None -301 72 Mouse 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
122 8219 9 3H-5CT -1 11 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
156314 8219 9 3H-5CT -1 11 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL1332062 8219 9 3H-5CT -1 11 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N None
4223 10764 94 None -81 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
6918314 10764 94 None -81 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
7427 10764 94 None -81 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
CHEMBL439849 10764 94 None -81 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
DB06684 10764 94 None -81 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
Drug Central 441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 None
102 10899 48 None -851 49 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -851 49 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -851 49 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -851 49 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -851 49 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
11976 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 7707 59 3H-LSD -5 24 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
11976 7707 59 3H-LSD -5 24 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 7707 59 3H-LSD -5 24 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 7707 59 3H-LSD -5 24 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 7707 59 3H-LSD -5 24 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
25107718 194317 0 UNDEFINED 18 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 535 12 1 6 4.7 CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 None
CHEMBL494458 194317 0 UNDEFINED 18 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 535 12 1 6 4.7 CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1 None
240 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
2769 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
44279790 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
660 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL1729 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL560739 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
DB00604 7731 43 None -19 25 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
2402 10143 62 None -5 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 10143 62 None -5 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 10143 62 None -5 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 10143 62 None -5 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 10143 62 None -5 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
103 10925 61 3H-LSD -6 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-LSD -6 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-LSD -6 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-LSD -6 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-LSD -6 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
1220 6975 55 3H-5HT -51 44 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -51 44 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -51 44 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -51 44 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
11954224 222732 0 3H-5HT -269 59 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
6450478 222791 0 3H-LSD -1 12 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 340 0 0 6 3.4 CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42 None
1353 8692 93 3H-5HT -120 85 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5HT -120 85 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5HT -120 85 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5HT -120 85 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5HT -120 85 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3033769 10054 61 3H-LSD -1380 18 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 346 5 2 4 2.9 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl None
3299 10054 61 3H-LSD -1380 18 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 346 5 2 4 2.9 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl None
94 10054 61 3H-LSD -1380 18 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 346 5 2 4 2.9 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl None
CHEMBL8809 10054 61 3H-LSD -1380 18 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 346 5 2 4 2.9 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl None
DB12518 10054 61 3H-LSD -1380 18 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 346 5 2 4 2.9 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl None
1577 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
2537 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5355 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5501 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
643497 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
688272 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
958 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
960 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL196677 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL26 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL267044 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB00391 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB16021 10475 110 3H-LSD -208 20 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
54477 91428 36 3H-LSD -69 22 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 370 6 1 4 2.7 CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC None
CHEMBL22242 91428 36 3H-LSD -69 22 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 370 6 1 4 2.7 CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC None
53389 105223 23 3H-LSD -1 6 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 3.9 C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1 None
CHEMBL275707 105223 23 3H-LSD -1 6 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 3.9 C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1 None
33630 185736 99 3H-LSD -891 28 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL47050 185736 99 3H-LSD -891 28 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
None 222766 0 3H-LSD -1 2 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 342 1 1 5 1.8 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl None
None 222767 0 3H-LSD -1 2 Rat 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 334 4 0 3 4.9 C[N+](C)(CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)[O-] None
277 8083 62 3H-5CT -301 50 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5CT -301 50 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5CT -301 50 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5CT -301 50 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5CT -301 50 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2176 9901 68 3H-MESULERGINE -1584 27 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-MESULERGINE -1584 27 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-MESULERGINE -1584 27 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-MESULERGINE -1584 27 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-MESULERGINE -1584 27 Guinea pig 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2726 7706 68 3H-5HT -301 72 Mouse 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-5HT -301 72 Mouse 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-5HT -301 72 Mouse 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-5HT -301 72 Mouse 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-5HT -301 72 Mouse 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
1577 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
2537 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5355 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
5501 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
643497 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
688272 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
958 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
960 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL196677 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL26 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
CHEMBL267044 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB00391 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
DB16021 10475 110 3H-LSD -269 20 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N None
2543 10479 68 3H-5HT -93 32 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
2543 10479 68 3H-5HT -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -93 32 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -93 32 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -93 32 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -93 32 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1220 6975 55 3H-5HT -208 44 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1220 6975 55 3H-5HT -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -208 44 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -208 44 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -208 44 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1220 6975 55 UNDEFINED -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 UNDEFINED -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 UNDEFINED -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 UNDEFINED -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
283 9904 57 3H-5CT -28 12 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
4847 9904 57 3H-5CT -28 12 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
CHEMBL18331 9904 57 3H-5CT -28 12 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 None
None 222831 0 3H-5CT -67 8 Guinea pig 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 339 4 3 3 1.9 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
1220 6975 55 125I-LSD -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 125I-LSD -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 125I-LSD -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 125I-LSD -75 44 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
1342 6824 49 125I-LSD -13 19 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 125I-LSD -13 19 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 125I-LSD -13 19 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
115 10563 80 125I-LSD -8 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
4296 10563 80 125I-LSD -8 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
CHEMBL274866 10563 80 125I-LSD -8 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
24768519 99638 0 UNDEFINED 1 3 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 461 8 1 3 5.9 CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243953 99638 0 UNDEFINED 1 3 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 461 8 1 3 5.9 CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
25108475 194264 0 UNDEFINED -2 3 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 419 8 0 3 5.0 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
CHEMBL494119 194264 0 UNDEFINED -2 3 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 419 8 0 3 5.0 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1 None
681 8247 72 125I-LSD -354 38 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 125I-LSD -354 38 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 125I-LSD -354 38 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 125I-LSD -354 38 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 125I-LSD -354 38 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
484 9633 51 125I-LSD -7 35 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 125I-LSD -7 35 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 125I-LSD -7 35 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
2176 9901 68 125I-LSD -6165 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 125I-LSD -6165 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 125I-LSD -6165 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 125I-LSD -6165 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 125I-LSD -6165 27 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
2543 10479 68 125I-LSD -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 125I-LSD -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 125I-LSD -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 125I-LSD -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 125I-LSD -44 32 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
108182 10903 22 125I-LSD -2 17 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
245 10903 22 125I-LSD -2 17 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
CHEMBL18041 10903 22 125I-LSD -2 17 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
73333 12735 31 3H-LSD -35 9 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 401 7 1 2 4.2 CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL1079935 12735 31 3H-LSD -35 9 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 401 7 1 2 4.2 CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
73333 12735 31 3H-LSD -35 9 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 401 7 1 2 4.2 CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL1079935 12735 31 3H-LSD -35 9 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 401 7 1 2 4.2 CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
135 9310 43 3H-5HT -83 56 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -83 56 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -83 56 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -83 56 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -83 56 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2543 10479 68 125I-LSD -44 32 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 125I-LSD -44 32 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 125I-LSD -44 32 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 125I-LSD -44 32 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 125I-LSD -44 32 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
15387 52596 55 3H-LSD -85 24 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 263 5 0 2 3.5 CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1 None
CHEMBL1531134 52596 55 3H-LSD -85 24 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 263 5 0 2 3.5 CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1 None
15387 52596 55 3H-LSD -85 24 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 263 5 0 2 3.5 CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1 None
CHEMBL1531134 52596 55 3H-LSD -85 24 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 263 5 0 2 3.5 CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1 None
10624 77075 19 3H-LSD -46 32 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
138543650 77075 19 3H-LSD -46 32 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
CHEMBL194378 77075 19 3H-LSD -46 32 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
2543 10479 68 None -93 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 None -93 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 None -93 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 None -93 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 None -93 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5 6927 72 3H- LSD -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H- LSD -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H- LSD -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H- LSD -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
2865 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
25107516 193964 0 UNDEFINED -4 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 433 8 0 3 5.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
CHEMBL492282 193964 0 UNDEFINED -4 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 433 8 0 3 5.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1 None
133 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
133 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -16 43 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
191 7191 98 None -41 29 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 None -41 29 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 None -41 29 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 None -41 29 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 None -41 29 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
1353 8692 93 None -74 85 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -74 85 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -74 85 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -74 85 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -74 85 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
107 6929 121 3H-5HT -9 31 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -9 31 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -9 31 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
135398737 7745 93 3H-LSD -7 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -7 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -7 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -7 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -7 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1588 9105 27 3H-5HT -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
1588 9105 27 UNDEFINED -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-5HT -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 UNDEFINED -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-5HT -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 UNDEFINED -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-5HT -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 UNDEFINED -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-5HT -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 UNDEFINED -6 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
4106 9280 22 3H-5HT -15 33 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -15 33 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -15 33 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -15 33 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5 6927 72 3H-5CT -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5CT -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5CT -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5CT -3 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
206 9271 16 3H-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
180 7189 56 None -12 40 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
180 7189 56 None -99 40 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 None -12 40 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 None -99 40 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 None -12 40 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 None -99 40 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 None -12 40 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 None -99 40 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 None -12 40 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 None -99 40 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2477 7532 59 None -7 29 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
2477 7532 59 None -21 29 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 None -7 29 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 None -21 29 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 None -7 29 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 None -21 29 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 None -7 29 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 None -21 29 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 None -7 29 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 None -21 29 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
1524 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -38 51 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
133 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1353 8692 93 None -263 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -263 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -263 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -263 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -263 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
133 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -10 43 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1524 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -501 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
114948 67071 14 None 1 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 577 5 3 6 2.5 CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 None
CHEMBL1743263 67071 14 None 1 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 577 5 3 6 2.5 CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 None
2337 10030 77 None -28 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 None -28 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 None -28 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 None -28 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 None -28 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
214 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 None -52 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1830 9368 44 None -30 28 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 None -30 28 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 None -30 28 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 None -30 28 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 None -30 28 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
1353 8692 93 None -120 85 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -120 85 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -120 85 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -120 85 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -120 85 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1816 9318 102 None -165 18 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
4205 9318 102 None -165 18 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
7241 9318 102 None -165 18 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
CHEMBL654 9318 102 None -165 18 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
DB00370 9318 102 None -165 18 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
2543 10479 68 None -44 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 None -44 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 None -44 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 None -44 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 None -44 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1621 9207 17 3H-LSD -34 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 3H-LSD -34 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 3H-LSD -34 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 3H-LSD -34 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 3H-LSD -34 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2389 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
6971132 222788 0 3H-LSD -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 268 1 2 2 2.1 CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O None
2865 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
2865 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
1524 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -169 51 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
4806 10780 88 None 1 13 Rat 8.2 pKi = 8.2 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
7351 10780 88 None 1 13 Rat 8.2 pKi = 8.2 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
9966051 10780 88 None 1 13 Rat 8.2 pKi = 8.2 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
CHEMBL2104993 10780 88 None 1 13 Rat 8.2 pKi = 8.2 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
DB09068 10780 88 None 1 13 Rat 8.2 pKi = 8.2 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
228 7233 28 None -6 23 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
33 7233 28 None -6 23 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6005 7233 28 None -6 23 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
CHEMBL53 7233 28 None -6 23 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
DB00714 7233 28 None -6 23 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
10531 8202 21 None -87 24 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None -87 24 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None -87 24 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None -87 24 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None -87 24 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
1588 9105 27 3H-LSD -19 44 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-LSD -19 44 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-LSD -19 44 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-LSD -19 44 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-LSD -19 44 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2895 210371 41 None -1 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 275 3 0 1 4.6 CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 None
CHEMBL669 210371 41 None -1 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 275 3 0 1 4.6 CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 None
277 8083 62 None -63 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 None -63 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 None -63 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 None -63 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 None -63 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
3652 10869 79 None -6 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
57 10869 79 None -6 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
60809 10869 79 None -6 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
CHEMBL21536 10869 79 None -6 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
DB15357 10869 79 None -6 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
133 9274 52 3H-5CT -15 43 Guinea pig 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5CT -15 43 Guinea pig 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5CT -15 43 Guinea pig 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5CT -15 43 Guinea pig 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5CT -15 43 Guinea pig 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2389 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-LSD -8 66 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
11154555 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
5037 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
7671 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL2028019 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL3085826 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB06016 7587 62 None -117 12 Human 8.2 pKi = 8.2 Binding
CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
2470 10425 50 None -1258 58 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -1258 58 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -1258 58 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -1258 58 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -1258 58 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
135398745 9688 112 None -95 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 None -95 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 None -95 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 None -95 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135409468 8816 69 3H-LSD -21 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
333 8816 69 3H-LSD -21 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
CHEMBL845 8816 69 3H-LSD -21 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
135398737 7745 93 3H-5HT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-5HT -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 UNDEFINED -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 UNDEFINED -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 UNDEFINED -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 UNDEFINED -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 UNDEFINED -7 90 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
133 9274 52 3H-5HT -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2470 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5567 49576 27 3H-LSD -69 8 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 409 6 1 3 4.8 O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 None
CHEMBL15023 49576 27 3H-LSD -69 8 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 409 6 1 3 4.8 O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 None
133 9274 52 UNDEFINED -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 UNDEFINED -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 UNDEFINED -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 UNDEFINED -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 UNDEFINED -16 43 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2470 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -1096 58 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
135398737 7745 93 3H-5CT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5CT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5CT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5CT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5CT -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
100 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
107780 8625 54 3H-5CT -2691 18 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
14 8625 54 3H-5CT -2691 18 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL15928 8625 54 3H-5CT -2691 18 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
1524 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5CT -1023 51 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
1150 10650 121 3H-5CT -1 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5CT -1 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5CT -1 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5CT -1 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
None 223018 0 3H-LSD -64565 29 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
135398737 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
206 9271 16 3H-5CT -15 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5CT -15 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5CT -15 25 Guinea pig 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
135398737 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135 9310 43 3H-5CT -138 56 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5CT -138 56 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5CT -138 56 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5CT -138 56 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5CT -138 56 Guinea pig 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
135 9310 43 3H-5HT -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
135 9310 43 UNDEFINED -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 UNDEFINED -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 UNDEFINED -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 UNDEFINED -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 UNDEFINED -50 56 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2274 9947 58 3H-LSD -3235 31 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4917 9947 58 3H-LSD -3235 31 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
7279 9947 58 3H-LSD -3235 31 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL728 9947 58 3H-LSD -3235 31 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00433 9947 58 3H-LSD -3235 31 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
180 7189 56 None -125 40 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 None -125 40 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 None -125 40 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 None -125 40 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 None -125 40 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
135 9310 43 None -21 56 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -21 56 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -21 56 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -21 56 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -21 56 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
135398745 9688 112 None -34 65 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 None -34 65 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 None -34 65 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 None -34 65 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
114948 67071 14 None -1 3 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 577 5 3 6 2.5 CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 None
CHEMBL1743263 67071 14 None -1 3 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 577 5 3 6 2.5 CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 None
135 9310 43 None -83 56 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -83 56 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -83 56 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -83 56 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -83 56 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
206 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
129211 10521 78 None -151 16 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 None -151 16 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 None -151 16 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 None -151 16 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 None -151 16 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
24768516 99361 0 UNDEFINED 11 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 433 9 1 3 5.1 CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL243523 99361 0 UNDEFINED 11 3 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 433 9 1 3 5.1 CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
206 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 125I-LSD -6 25 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
100 10577 58 None -28 54 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 None -28 54 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 None -28 54 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 None -28 54 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 None -28 54 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
135 9310 43 None -50 56 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -50 56 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -50 56 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -50 56 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -50 56 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2470 10425 50 None -1096 58 Mouse 8.1 pKi = 8.1 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -1096 58 Mouse 8.1 pKi = 8.1 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -1096 58 Mouse 8.1 pKi = 8.1 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -1096 58 Mouse 8.1 pKi = 8.1 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -1096 58 Mouse 8.1 pKi = 8.1 Binding
Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
62865 8057 0 None -7 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
746 8057 0 None -7 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
84 8057 0 None -7 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
CHEMBL2104153 8057 0 None -7 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
DB09000 8057 0 None -7 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 None
100 10577 58 None -18 54 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 None -18 54 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 None -18 54 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 None -18 54 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 None -18 54 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
277 8083 62 None -43 50 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 None -43 50 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 None -43 50 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 None -43 50 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 None -43 50 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
11954224 222732 0 None -269 59 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
1613 9127 53 None -14 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 None -14 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 None -14 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 None -14 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 None -14 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
191 7191 98 None -19 29 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 None -19 29 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 None -19 29 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 None -19 29 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 None -19 29 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
135398737 7745 93 None -9 90 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -9 90 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -9 90 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -9 90 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -9 90 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
2726 7706 68 None -13 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None -13 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None -13 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None -13 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None -13 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
49831411 224525 0 None -1 15 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 659 19 0 6 8.7 CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 None
133 9274 52 None -36 43 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -36 43 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -36 43 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -36 43 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -36 43 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2435 10362 83 None -36 48 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 None -36 48 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 None -36 48 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 None -36 48 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 None -36 48 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2220 9908 82 None -3 14 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
Drug Central 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 None
27400 9908 82 None -3 14 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
Drug Central 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 None
93 9908 82 None -3 14 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
Drug Central 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 None
CHEMBL294951 9908 82 None -3 14 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
Drug Central 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 None
DB06153 9908 82 None -3 14 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis
Drug Central 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 None
209 9831 97 None -25 23 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 None -25 23 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 None -25 23 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 None -25 23 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 None -25 23 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
209 9831 97 None -31 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 None -31 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 None -31 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 None -31 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 None -31 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
3294 8787 111 None -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 None -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 None -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 None -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 None -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
2726 7706 68 None -13 72 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None -13 72 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None -13 72 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None -13 72 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None -13 72 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
242 7258 124 None -15 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 None -15 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 None -15 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 None -15 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 None -15 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
3294 8787 111 None -21 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 None -21 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 None -21 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 None -21 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 None -21 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
4806 10780 88 None -8 13 Human 8.1 pKi = 8.1 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
7351 10780 88 None -8 13 Human 8.1 pKi = 8.1 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
9966051 10780 88 None -8 13 Human 8.1 pKi = 8.1 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
CHEMBL2104993 10780 88 None -8 13 Human 8.1 pKi = 8.1 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
DB09068 10780 88 None -8 13 Human 8.1 pKi = 8.1 Binding
antagonistantagonist
Drug Central 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 None
135398737 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -13 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
242 7258 124 None -14 51 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 None -14 51 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 None -14 51 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 None -14 51 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 None -14 51 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
134 9292 24 None -24 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -24 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -24 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -24 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -24 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
49831411 224525 0 None -1 15 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 659 19 0 6 8.7 CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 None
3294 8787 111 3H-LSD -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-LSD -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-LSD -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-LSD -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-LSD -41 44 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
212 10578 47 None -7 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
2639 10578 47 None -7 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
941651 10578 47 None -7 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
CHEMBL1201 10578 47 None -7 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
DB01623 10578 47 None -7 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
134 9292 24 None -18 67 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -18 67 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -18 67 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -18 67 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -18 67 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
134 9292 24 None -9 67 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -9 67 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -9 67 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -9 67 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -9 67 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1212 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1212 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1621 9207 17 3H-MESULERGINE -34 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 3H-MESULERGINE -34 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 3H-MESULERGINE -34 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 3H-MESULERGINE -34 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 3H-MESULERGINE -34 44 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2601 10552 33 3H-5CT -20 21 Guinea pig 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 3H-5CT -20 21 Guinea pig 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 3H-5CT -20 21 Guinea pig 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 3H-5CT -20 21 Guinea pig 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 3H-5CT -20 21 Guinea pig 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
2726 7706 68 3H-5HT -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-5HT -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-5HT -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-5HT -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-5HT -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
100 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-LSD -18 54 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2726 7706 68 UNDEFINED -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 UNDEFINED -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 UNDEFINED -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 UNDEFINED -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 UNDEFINED -13 72 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
162265 209053 22 3H-LSD -16 44 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 3H-LSD -16 44 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 3H-LSD -16 44 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
None 223018 0 3H-LSD -64565 29 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
25107583 199656 0 UNDEFINED -2 3 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 489 12 1 7 3.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
CHEMBL522194 199656 0 UNDEFINED -2 3 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 489 12 1 7 3.0 COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
1712 9270 43 3H-LSD -18 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
4078 9270 43 3H-LSD -18 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
7227 9270 43 3H-LSD -18 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
CHEMBL1088 9270 43 3H-LSD -18 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
DB00933 9270 43 3H-LSD -18 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
1712 9270 43 3H-LSD -18 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
4078 9270 43 3H-LSD -18 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
7227 9270 43 3H-LSD -18 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
CHEMBL1088 9270 43 3H-LSD -18 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
DB00933 9270 43 3H-LSD -18 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 386 4 0 4 4.9 CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C None
3337 213146 27 3H-LSD -169 40 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-LSD -169 40 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-LSD -169 40 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-LSD -169 40 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-LSD -169 40 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
1524 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
1524 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5HT -501 51 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5HT -169 51 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
25107582 194363 0 UNDEFINED -9 3 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 501 12 1 6 4.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
CHEMBL494661 194363 0 UNDEFINED -9 3 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 501 12 1 6 4.1 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1 None
277 8083 62 3H-5HT -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 3H-5HT -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 3H-5HT -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 3H-5HT -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 3H-5HT -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
135398737 7745 93 3H-LSD -13 90 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-LSD -13 90 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-LSD -13 90 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-LSD -13 90 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-LSD -13 90 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
277 8083 62 UNDEFINED -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 UNDEFINED -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 UNDEFINED -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 UNDEFINED -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 UNDEFINED -43 50 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
None 222750 0 125I-LSD -616 15 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
None 222750 0 125I-LSD -616 15 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
1524 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5CT -501 51 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
2470 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
31101 7516 40 None -25 35 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 None -25 35 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 None -25 35 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 None -25 35 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 None -25 35 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
10531 8202 21 None -23 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None -23 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None -23 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None -23 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None -23 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
1212 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1212 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-LSD -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-LSD -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1212 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1212 8443 50 None -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 None -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 None -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 None -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 None -15 65 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3389 224490 0 None -1 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 549 12 0 6 6.8 CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 None
5 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -3 53 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
133 9274 52 None -16 43 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -16 43 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -16 43 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -16 43 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -16 43 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
135398737 7745 93 None -7 90 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -7 90 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -7 90 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -7 90 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -7 90 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
133 9274 52 None -10 43 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -10 43 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -10 43 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -10 43 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -10 43 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
11976 7707 59 None -5 24 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 7707 59 None -5 24 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 7707 59 None -5 24 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 7707 59 None -5 24 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
145 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
2865 10915 73 None -12 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 None -12 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 None -12 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 None -12 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 None -12 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
25107647 194263 0 UNDEFINED 11 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 453 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1 None
CHEMBL494118 194263 0 UNDEFINED 11 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 453 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1 None
145 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 3H-5HT -4 30 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
103 10925 61 None -6 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 None -6 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 None -6 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 None -6 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 None -6 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
11978813 7508 79 None -6 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
5014 7508 79 None -6 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
7672 7508 79 None -6 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
CHEMBL2105760 7508 79 None -6 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
DB09128 7508 79 None -6 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
2389 10104 118 None -8 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 None -8 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 None -8 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 None -8 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 None -8 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
115237 62359 119 None -20 54 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 None -20 54 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
25107580 194292 0 UNDEFINED 2 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 432 10 1 4 4.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
CHEMBL494312 194292 0 UNDEFINED 2 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 432 10 1 4 4.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
439280 126797 107 None -1 2 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O None
6971044 126797 107 None -1 2 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O None
CHEMBL350221 126797 107 None -1 2 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O None
1621 9207 17 None -34 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 None -34 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 None -34 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 None -34 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 None -34 44 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
103 10925 61 None -2 53 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 None -2 53 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 None -2 53 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 None -2 53 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 None -2 53 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2389 10104 118 None -7 66 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 None -7 66 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 None -7 66 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 None -7 66 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 None -7 66 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
214 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-LSD -95 30 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
135 9310 43 3H-5HT -83 56 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-5HT -83 56 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-5HT -83 56 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-5HT -83 56 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-5HT -83 56 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
24768526 100006 0 UNDEFINED -41 2 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 422 8 1 4 3.2 O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21 None
CHEMBL244792 100006 0 UNDEFINED -41 2 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 422 8 1 4 3.2 O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21 None
4452 9538 19 3H-LSD -2754 18 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl None
983 9538 19 3H-LSD -2754 18 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl None
CHEMBL20734 9538 19 3H-LSD -2754 18 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl None
24768521 99787 0 UNDEFINED -19 2 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 420 8 2 4 4.1 Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
CHEMBL244162 99787 0 UNDEFINED -19 2 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 420 8 2 4 4.1 Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 None
1342 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
134 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1342 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -33 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
134 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -24 67 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
2477 7532 59 [3H]-5-carboxamidotryptamine -128 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 [3H]-5-carboxamidotryptamine -128 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 [3H]-5-carboxamidotryptamine -128 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 [3H]-5-carboxamidotryptamine -128 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 [3H]-5-carboxamidotryptamine -128 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
1613 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
1613 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
141 8209 35 3H-LSD 1 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 188 3 1 1 2.3 CN(CCc1c[nH]c2c1cccc2)C None
6089 8209 35 3H-LSD 1 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 188 3 1 1 2.3 CN(CCc1c[nH]c2c1cccc2)C None
CHEMBL12420 8209 35 3H-LSD 1 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 188 3 1 1 2.3 CN(CCc1c[nH]c2c1cccc2)C None
DB01488 8209 35 3H-LSD 1 22 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 188 3 1 1 2.3 CN(CCc1c[nH]c2c1cccc2)C None
6852400 222716 0 3H-5CT -1023 22 Guinea pig 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
73759726 222716 0 3H-5CT -1023 22 Guinea pig 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
1613 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-LSD -23 44 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
37459 7533 13 UNDEFINED -194 24 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
62 7533 13 UNDEFINED -194 24 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
CHEMBL8514 7533 13 UNDEFINED -194 24 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
2105 9828 37 None -1 32 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 None -1 32 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 None -1 32 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 None -1 32 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 None -1 32 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
25107579 194221 0 UNDEFINED -1 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 436 10 1 5 4.3 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
CHEMBL493909 194221 0 UNDEFINED -1 3 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 436 10 1 5 4.3 CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1 None
None 222717 0 3H-5HT -151 21 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 583 4 3 6 2.1 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C None
None 222717 0 3H-5HT -151 21 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 583 4 3 6 2.1 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C None
16362 9899 71 None -5 29 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 None -5 29 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 None -5 29 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 None -5 29 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 None -5 29 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
1588 9105 27 None -6 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 None -6 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 None -6 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 None -6 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 None -6 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
213046 9164 59 None 2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 None
4168 9164 59 None 2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 None
7461 9164 59 None 2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 None
CHEMBL1237021 9164 59 None 2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 None
DB08815 9164 59 None 2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 None
16362 9899 71 None -11 29 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 None -11 29 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 None -11 29 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 None -11 29 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 None -11 29 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
206 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
2865 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
206 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 125I-LSD -6 25 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
2865 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-LSD -12 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
46780481 114308 20 None -16 53 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 None -16 53 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 None -16 53 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 None -16 53 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
1621 9207 17 3H-5HT -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 3H-5HT -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 3H-5HT -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 3H-5HT -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 3H-5HT -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
103 10925 61 3H-LSD -6 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-LSD -6 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-LSD -6 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-LSD -6 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-LSD -6 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
None 222722 0 3H-5HT -7 11 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
1621 9207 17 UNDEFINED -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 9207 17 UNDEFINED -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 9207 17 UNDEFINED -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 9207 17 UNDEFINED -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 9207 17 UNDEFINED -34 44 Rat 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
242 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-LSD -15 51 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
2470 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-LSD -389 58 Rat 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
6852400 222716 0 3H-5HT -223 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
73759726 222716 0 3H-5HT -223 22 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
180 7189 56 3H-5HT -125 40 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 3H-5HT -125 40 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 3H-5HT -125 40 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 3H-5HT -125 40 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 3H-5HT -125 40 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
134 9292 24 3H-5CT -37 67 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5CT -37 67 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5CT -37 67 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5CT -37 67 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5CT -37 67 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1353 8692 93 3H-5CT -3801 85 Guinea pig 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5CT -3801 85 Guinea pig 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5CT -3801 85 Guinea pig 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5CT -3801 85 Guinea pig 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5CT -3801 85 Guinea pig 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
10257 7525 31 3H-5CT -13 19 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
144 7525 31 3H-5CT -13 19 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
CHEMBL416526 7525 31 3H-5CT -13 19 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
DB01445 7525 31 3H-5CT -13 19 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
2543 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
2543 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -93 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
100 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-LSD -28 54 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
4806 10780 88 None -8 13 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 21486038
7351 10780 88 None -8 13 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 21486038
9966051 10780 88 None -8 13 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 21486038
CHEMBL2104993 10780 88 None -8 13 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 21486038
DB09068 10780 88 None -8 13 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 298 3 1 3 3.9 Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 21486038
281 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 9720804
5312148 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 9720804
CHEMBL12264 10283 28 None 1 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 0 3 3.1 CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C 9720804
242 7258 124 None -14 51 Rat 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10327430
34 7258 124 None -14 51 Rat 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10327430
60795 7258 124 None -14 51 Rat 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10327430
CHEMBL1112 7258 124 None -14 51 Rat 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10327430
DB01238 7258 124 None -14 51 Rat 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10327430
11959 8318 0 None -2 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 405 5 1 7 3.0 Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl 22824189
9909267 8318 0 None -2 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 405 5 1 7 3.0 Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl 22824189
11151899 8918 13 None 1 4 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 22570363
8432 8918 13 None 1 4 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 22570363
CHEMBL4205783 8918 13 None 1 4 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 337 3 1 3 3.9 Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1 22570363
24825775 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 19118950
3929 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 19118950
CHEMBL4205349 8305 14 None 346 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 257 4 0 3 2.8 CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C 19118950
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10052959
8431 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 12825922
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10052959
9843179 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 12825922
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 10052959
CHEMBL69257 8266 9 None 22 5 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 12825922
10028436 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 12392747
3237 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 12392747
CHEMBL95104 10305 5 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 12392747
3233 10285 44 None 2 12 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
3247 10285 44 None 2 12 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
6604889 10285 44 None 2 12 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
CHEMBL282199 10285 44 None 2 12 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
DB13988 10285 44 None 2 12 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O 10807680
5 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394362
5 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8397408
5202 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394362
5202 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8397408
CHEMBL39 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394362
CHEMBL39 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8397408
DB08839 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394362
DB08839 6927 72 None -5 53 Rat 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8397408
23642275 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 23541835
8433 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 23541835
CHEMBL2164327 7270 31 None 60 3 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C 23541835
25107716 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 18800769
8436 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 18800769
CHEMBL522691 9130 43 None 3 7 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 18800769
16362 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 7908055
2172 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 7908055
90 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 7908055
CHEMBL1423 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 7908055
DB01100 9899 71 None -5 29 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 7908055
213046 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 20404009
4168 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 20404009
7461 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 20404009
CHEMBL1237021 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 20404009
DB08815 9164 59 None 2 9 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 20404009
11224758 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 17649988
8435 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 17649988
CHEMBL225284 9132 5 None -4 6 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 17649988
23643664 9129 8 None 1 5 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 17649988
8434 9129 8 None 1 5 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 17649988
CHEMBL243954 9129 8 None 1 5 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 17649988
162265 209053 22 None -16 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 None -16 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 None -16 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
3337 213146 27 None -169 40 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 None -169 40 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 None -169 40 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 None -169 40 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 None -169 40 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
202 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
213 10625 55 None -9 43 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 10625 55 None -9 43 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 10625 55 None -9 43 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 10625 55 None -9 43 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 10625 55 None -9 43 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
119570 9933 96 None -93 39 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 None -93 39 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 None -93 39 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 None -93 39 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 None -93 39 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
179 7188 115 None -9 50 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 None -9 50 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 None -9 50 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 None -9 50 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 None -9 50 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2726 7706 68 None -301 72 Mouse 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 8394987
621 7706 68 None -301 72 Mouse 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 8394987
83 7706 68 None -301 72 Mouse 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 8394987
CHEMBL71 7706 68 None -301 72 Mouse 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 8394987
DB00477 7706 68 None -301 72 Mouse 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 8394987
18971832 9196 0 None -812 13 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
21 9196 0 None -812 13 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
CHEMBL3186179 9196 0 None -812 13 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
257 10266 13 None -19952 4 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 474 6 1 6 3.3 CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N 11414657
5311423 10266 13 None -19952 4 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 474 6 1 6 3.3 CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N 11414657
CHEMBL114112 10266 13 None -19952 4 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 474 6 1 6 3.3 CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N 11414657
29 7579 0 None -5011 9 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 456 5 1 8 3.4 Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 12130738
9805719 7579 0 None -5011 9 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 456 5 1 8 3.4 Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 12130738
CHEMBL2027925 7579 0 None -5011 9 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 456 5 1 8 3.4 Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 12130738
102 10899 48 None -851 49 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8226867
3659 10899 48 None -851 49 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8226867
8969 10899 48 None -851 49 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8226867
CHEMBL15245 10899 48 None -851 49 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8226867
DB01392 10899 48 None -851 49 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8226867
240 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
2769 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
44279790 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
660 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
CHEMBL1729 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
CHEMBL560739 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
DB00604 7731 43 None -19 25 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 8394987
2543 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8226867
2543 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9298538
5358 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8226867
5358 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9298538
54 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8226867
54 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9298538
CHEMBL128 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8226867
CHEMBL128 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9298538
DB00669 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8226867
DB00669 10479 68 None -93 32 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9298538
1524 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
1524 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
1524 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
1524 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
197 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
197 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
197 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
197 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
3822 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
3822 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
3822 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
3822 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
88 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
88 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
88 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
88 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
CHEMBL51 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
CHEMBL51 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
CHEMBL51 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
CHEMBL51 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
DB12465 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11414657
DB12465 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8226867
DB12465 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9298538
DB12465 8962 96 None -501 51 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 9720804
1353 8692 93 None -74 85 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8394987
3559 8692 93 None -74 85 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8394987
86 8692 93 None -74 85 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8394987
CHEMBL54 8692 93 None -74 85 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8394987
DB00502 8692 93 None -74 85 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8394987
115 10563 80 None -12 27 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394987
4296 10563 80 None -12 27 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394987
CHEMBL274866 10563 80 None -12 27 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394987
2543 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
2543 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8397408
5358 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
5358 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8397408
54 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
54 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8397408
CHEMBL128 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
CHEMBL128 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8397408
DB00669 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
DB00669 10479 68 None -44 32 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8397408
180 7189 56 None -99 40 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394987
200 7189 56 None -99 40 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394987
2160 7189 56 None -99 40 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394987
CHEMBL629 7189 56 None -99 40 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394987
DB00321 7189 56 None -99 40 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394987
2477 7532 59 None -7 29 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8394987
2477 7532 59 None -21 29 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8397408
36 7532 59 None -7 29 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8394987
36 7532 59 None -21 29 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8397408
437 7532 59 None -7 29 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8394987
437 7532 59 None -21 29 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8397408
CHEMBL49 7532 59 None -7 29 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8394987
CHEMBL49 7532 59 None -21 29 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8397408
DB00490 7532 59 None -7 29 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8394987
DB00490 7532 59 None -21 29 Rat 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 8397408
1524 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
197 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
3822 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
88 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
CHEMBL51 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
DB12465 8962 96 None -38 51 Mouse 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394987
1353 8692 93 None -263 85 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 9298538
1353 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 7908055
1353 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8397408
1353 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8997630
3559 8692 93 None -263 85 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 9298538
3559 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 7908055
3559 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8397408
3559 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8997630
86 8692 93 None -263 85 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 9298538
86 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 7908055
86 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8397408
86 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8997630
CHEMBL54 8692 93 None -263 85 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 9298538
CHEMBL54 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 7908055
CHEMBL54 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8397408
CHEMBL54 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8997630
DB00502 8692 93 None -263 85 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 9298538
DB00502 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 7908055
DB00502 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8397408
DB00502 8692 93 None -120 85 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 8997630
115 10563 80 None -8 27 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394362
4296 10563 80 None -8 27 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394362
CHEMBL274866 10563 80 None -8 27 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8394362
1355 8792 88 None -21 16 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 8394362
142 8792 88 None -21 16 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 8394362
CHEMBL478 8792 88 None -21 16 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 8394362
DB12110 8792 88 None -21 16 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1 8394362
282 8201 0 None -3548 7 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 8397408
522609 8201 0 None -3548 7 Rat 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 8397408
12 8335 17 None -13 7 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10715164
6918513 8335 17 None -13 7 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10715164
CHEMBL267615 8335 17 None -13 7 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC 10715164
135398745 9688 112 None -95 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 9720804
47 9688 112 None -95 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 9720804
CHEMBL715 9688 112 None -95 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 9720804
DB00334 9688 112 None -95 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 9720804
1220 6975 55 None -199 44 Mouse 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394987
31 6975 55 None -199 44 Mouse 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394987
7 6975 55 None -199 44 Mouse 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394987
CHEMBL56 6975 55 None -199 44 Mouse 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394987
1524 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
197 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
3822 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
88 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
CHEMBL51 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
DB12465 8962 96 None -169 51 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 8394362
267 8229 0 None 1 2 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 463 7 2 5 4.6 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O 10327430
9847259 8229 0 None 1 2 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 463 7 2 5 4.6 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O 10327430
CHEMBL4214961 8229 0 None 1 2 Rat 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 463 7 2 5 4.6 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O 10327430
1346 6871 117 None -147 9 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 8394362
280 6871 117 None -147 9 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 8394362
9899402 6871 117 None -147 9 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 8394362
CHEMBL9666 6871 117 None -147 9 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 192 2 1 3 1.1 COc1ccccc1N1CCNCC1 8394362
10531 8202 21 None -87 24 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8397408
121 8202 21 None -87 24 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8397408
888 8202 21 None -87 24 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8397408
CHEMBL1732 8202 21 None -87 24 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8397408
DB00320 8202 21 None -87 24 Rat 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8397408
6918515 9390 38 None -4 7 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10715164
71 9390 38 None -4 7 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10715164
CHEMBL7318 9390 38 None -4 7 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 294 5 1 2 3.9 COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1 10715164
1150 10650 121 None -6 25 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8226867
125 10650 121 None -6 25 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8226867
CHEMBL6640 10650 121 None -6 25 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8226867
DB08653 10650 121 None -6 25 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8226867
135398745 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 7908055
135398745 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8997630
47 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 7908055
47 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8997630
CHEMBL715 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 7908055
CHEMBL715 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8997630
DB00334 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 7908055
DB00334 9688 112 None -34 65 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8997630
277 8083 62 None -63 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8226867
2913 8083 62 None -63 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8226867
765 8083 62 None -63 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8226867
CHEMBL516 8083 62 None -63 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8226867
DB00434 8083 62 None -63 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8226867
108029 10187 57 None -125 13 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 228 2 2 2 2.6 COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 8394987
23 10187 57 None -125 13 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 228 2 2 2 2.6 COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 8394987
CHEMBL18785 10187 57 None -125 13 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 228 2 2 2 2.6 COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 8394987
3652 10869 79 None -6 18 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
57 10869 79 None -6 18 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
60809 10869 79 None -6 18 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
CHEMBL21536 10869 79 None -6 18 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
DB15357 10869 79 None -6 18 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
1220 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 11414657
1220 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8226867
1220 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9298538
1220 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9720804
31 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 11414657
31 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8226867
31 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9298538
31 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9720804
7 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 11414657
7 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8226867
7 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9298538
7 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9720804
CHEMBL56 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 11414657
CHEMBL56 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8226867
CHEMBL56 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9298538
CHEMBL56 6975 55 None -208 44 Human 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 9720804
180 7189 56 None -125 40 Rat 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394362
200 7189 56 None -125 40 Rat 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394362
2160 7189 56 None -125 40 Rat 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394362
CHEMBL629 7189 56 None -125 40 Rat 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394362
DB00321 7189 56 None -125 40 Rat 7.0 pKi None 7.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 8394362
10257 7525 31 None -39 19 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 8394987
144 7525 31 None -39 19 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 8394987
CHEMBL416526 7525 31 None -39 19 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 8394987
DB01445 7525 31 None -39 19 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C 8394987
37459 7533 13 None -194 24 Rat 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8397408
62 7533 13 None -194 24 Rat 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8397408
CHEMBL8514 7533 13 None -194 24 Rat 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8397408
282 8201 0 None -1122 7 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 8394987
522609 8201 0 None -1122 7 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 5 3 6 2.5 CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 8394987
3294 8787 111 None -41 44 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 11750183
71360 8787 111 None -41 44 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 11750183
87 8787 111 None -41 44 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 11750183
CHEMBL14376 8787 111 None -41 44 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 11750183
DB04946 8787 111 None -41 44 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 11750183
135 9310 43 None -21 56 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394987
1796 9310 43 None -21 56 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394987
4184 9310 43 None -21 56 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394987
CHEMBL6437 9310 43 None -21 56 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394987
DB06148 9310 43 None -21 56 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394987
1613 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 7908055
1613 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 8394362
205 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 7908055
205 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 8394362
3964 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 7908055
3964 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 8394362
CHEMBL831 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 7908055
CHEMBL831 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 8394362
DB00408 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 7908055
DB00408 9127 53 None -14 44 Rat 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 8394362
5074 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11414657
5074 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8226867
97 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11414657
97 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8226867
CHEMBL267777 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11414657
CHEMBL267777 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8226867
DB12693 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11414657
DB12693 10105 80 None -69 30 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8226867
1342 6824 49 None -33 19 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8226867
3 6824 49 None -33 19 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8226867
CHEMBL277120 6824 49 None -33 19 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8226867
100 10577 58 None -28 54 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 15821958
2637 10577 58 None -28 54 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 15821958
5452 10577 58 None -28 54 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 15821958
CHEMBL479 10577 58 None -28 54 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 15821958
DB00679 10577 58 None -28 54 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 15821958
135 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394362
135 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8397408
1796 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394362
1796 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8397408
4184 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394362
4184 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8397408
CHEMBL6437 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394362
CHEMBL6437 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8397408
DB06148 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8394362
DB06148 9310 43 None -50 56 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 8397408
62865 8057 0 None -7 15 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 12527336
746 8057 0 None -7 15 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 12527336
84 8057 0 None -7 15 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 12527336
CHEMBL2104153 8057 0 None -7 15 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 12527336
DB09000 8057 0 None -7 15 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 4 0 4 4.4 N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 12527336
209 9831 97 None -31 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 15821958
2113 9831 97 None -31 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 15821958
4748 9831 97 None -31 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 15821958
CHEMBL567 9831 97 None -31 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 15821958
DB00850 9831 97 None -31 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 15821958
2470 10425 50 None -1096 58 Mouse 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8394987
3300 10425 50 None -1096 58 Mouse 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8394987
5265 10425 50 None -1096 58 Mouse 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8394987
99 10425 50 None -1096 58 Mouse 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8394987
CHEMBL267930 10425 50 None -1096 58 Mouse 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8394987
100 10577 58 None -18 54 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 7908055
2637 10577 58 None -18 54 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 7908055
5452 10577 58 None -18 54 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 7908055
CHEMBL479 10577 58 None -18 54 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 7908055
DB00679 10577 58 None -18 54 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 7908055
277 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8394362
277 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8397408
2913 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8394362
2913 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8397408
765 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8394362
765 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8397408
CHEMBL516 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8394362
CHEMBL516 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8397408
DB00434 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8394362
DB00434 8083 62 None -43 50 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 8397408
1043 8363 14 None -549 29 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8394987
149 8363 14 None -549 29 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8394987
8223 8363 14 None -549 29 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8394987
CHEMBL442 8363 14 None -549 29 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8394987
DB00696 8363 14 None -549 29 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8394987
1220 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394362
1220 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8397408
31 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394362
31 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8397408
7 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394362
7 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8397408
CHEMBL56 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8394362
CHEMBL56 6975 55 None -75 44 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8397408
191 7191 98 None -19 29 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 7908055
201 7191 98 None -19 29 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 7908055
2170 7191 98 None -19 29 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 7908055
CHEMBL1113 7191 98 None -19 29 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 7908055
DB00543 7191 98 None -19 29 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 7908055
135398737 7745 93 None -9 90 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394987
38 7745 93 None -9 90 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394987
722 7745 93 None -9 90 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394987
CHEMBL42 7745 93 None -9 90 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394987
DB00363 7745 93 None -9 90 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394987
134 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 11414657
134 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8226867
134 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 9298538
1775 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 11414657
1775 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8226867
1775 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 9298538
9681 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 11414657
9681 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8226867
9681 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 9298538
CHEMBL1065 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 11414657
CHEMBL1065 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8226867
CHEMBL1065 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 9298538
DB00247 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 11414657
DB00247 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8226867
DB00247 9292 24 None -24 67 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 9298538
135 9310 43 None -83 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 9298538
1796 9310 43 None -83 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 9298538
4184 9310 43 None -83 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 9298538
CHEMBL6437 9310 43 None -83 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 9298538
DB06148 9310 43 None -83 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 9298538
2470 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11414657
2470 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8226867
2470 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 9298538
3300 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11414657
3300 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8226867
3300 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 9298538
5265 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11414657
5265 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8226867
5265 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 9298538
99 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11414657
99 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8226867
99 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 9298538
CHEMBL267930 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11414657
CHEMBL267930 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8226867
CHEMBL267930 10425 50 None -1258 58 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 9298538
135398737 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11414657
135398737 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 15821958
135398737 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 9720804
38 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11414657
38 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 15821958
38 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 9720804
722 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11414657
722 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 15821958
722 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 9720804
CHEMBL42 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11414657
CHEMBL42 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 15821958
CHEMBL42 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 9720804
DB00363 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11414657
DB00363 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 15821958
DB00363 7745 93 None -13 90 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 9720804
10171 6845 18 None -11 6 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8226867
272 6845 18 None -11 6 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8226867
CHEMBL274384 6845 18 None -11 6 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8226867
37459 7533 13 None -74 24 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8394987
62 7533 13 None -74 24 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8394987
CHEMBL8514 7533 13 None -74 24 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 8394987
279 8442 26 None -6 17 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 15821958
49381 8442 26 None -6 17 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 15821958
CHEMBL63756 8442 26 None -6 17 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 15821958
133 9274 52 None -36 43 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394987
1723 9274 52 None -36 43 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394987
28693 9274 52 None -36 43 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394987
CHEMBL19215 9274 52 None -36 43 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394987
DB13520 9274 52 None -36 43 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394987
145 6928 49 None -4 30 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
1832 6928 49 None -4 30 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
CHEMBL7257 6928 49 None -4 30 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
DB14010 6928 49 None -4 30 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8394362
1342 6824 49 None -13 19 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8394362
3 6824 49 None -13 19 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8394362
CHEMBL277120 6824 49 None -13 19 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8394362
2726 7706 68 None -13 72 Human 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 15821958
2726 7706 68 None -13 72 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908055
621 7706 68 None -13 72 Human 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 15821958
621 7706 68 None -13 72 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908055
83 7706 68 None -13 72 Human 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 15821958
83 7706 68 None -13 72 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908055
CHEMBL71 7706 68 None -13 72 Human 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 15821958
CHEMBL71 7706 68 None -13 72 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908055
DB00477 7706 68 None -13 72 Human 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 15821958
DB00477 7706 68 None -13 72 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908055
206 9271 16 None -16 25 Mouse 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394987
68848 9271 16 None -16 25 Mouse 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394987
CHEMBL12314 9271 16 None -16 25 Mouse 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394987
209 9831 97 None -25 23 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 7908055
2113 9831 97 None -25 23 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 7908055
4748 9831 97 None -25 23 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 7908055
CHEMBL567 9831 97 None -25 23 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 7908055
DB00850 9831 97 None -25 23 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 7908055
31101 7516 40 None -25 35 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 8394362
35 7516 40 None -25 35 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 8394362
403 7516 40 None -25 35 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 8394362
CHEMBL493 7516 40 None -25 35 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 8394362
DB01200 7516 40 None -25 35 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 8394362
1150 10650 121 None 1 25 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8394362
125 10650 121 None 1 25 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8394362
CHEMBL6640 10650 121 None 1 25 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8394362
DB08653 10650 121 None 1 25 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8394362
135398737 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 7908055
135398737 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394362
135398737 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8397408
135398737 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8997630
38 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 7908055
38 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394362
38 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8397408
38 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8997630
722 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 7908055
722 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394362
722 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8397408
722 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8997630
CHEMBL42 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 7908055
CHEMBL42 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394362
CHEMBL42 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8397408
CHEMBL42 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8997630
DB00363 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 7908055
DB00363 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8394362
DB00363 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8397408
DB00363 7745 93 None -7 90 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8997630
3294 8787 111 None -21 44 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 8997630
71360 8787 111 None -21 44 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 8997630
87 8787 111 None -21 44 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 8997630
CHEMBL14376 8787 111 None -21 44 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 8997630
DB04946 8787 111 None -21 44 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 8997630
163839 9729 0 None -1 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 10327430
268 9729 0 None -1 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 10327430
CHEMBL55171 9729 0 None -1 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 10327430
5074 10105 80 None -36 30 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8394362
97 10105 80 None -36 30 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8394362
CHEMBL267777 10105 80 None -36 30 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8394362
DB12693 10105 80 None -36 30 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 8394362
206 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 11414657
206 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8226867
206 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9298538
206 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9720804
68848 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 11414657
68848 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8226867
68848 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9298538
68848 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9720804
CHEMBL12314 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 11414657
CHEMBL12314 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8226867
CHEMBL12314 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9298538
CHEMBL12314 9271 16 None -10 25 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 9720804
2470 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 7908055
2470 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8397408
3300 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 7908055
3300 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8397408
5265 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 7908055
5265 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8397408
99 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 7908055
99 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8397408
CHEMBL267930 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 7908055
CHEMBL267930 10425 50 None -389 58 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 8397408
1212 8443 50 None -18 65 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 15821958
204 8443 50 None -18 65 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 15821958
3372 8443 50 None -18 65 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 15821958
CHEMBL726 8443 50 None -18 65 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 15821958
DB00623 8443 50 None -18 65 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 15821958
134 9292 24 None -9 67 Mouse 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394987
134 9292 24 None -18 67 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394362
1775 9292 24 None -9 67 Mouse 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394987
1775 9292 24 None -18 67 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394362
9681 9292 24 None -9 67 Mouse 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394987
9681 9292 24 None -18 67 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394362
CHEMBL1065 9292 24 None -9 67 Mouse 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394987
CHEMBL1065 9292 24 None -18 67 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394362
DB00247 9292 24 None -9 67 Mouse 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394987
DB00247 9292 24 None -18 67 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8394362
133 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394362
133 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8397408
1723 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394362
1723 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8397408
28693 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394362
28693 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8397408
CHEMBL19215 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394362
CHEMBL19215 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8397408
DB13520 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8394362
DB13520 9274 52 None -16 43 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8397408
206 9271 16 None -6 25 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394362
68848 9271 16 None -6 25 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394362
CHEMBL12314 9271 16 None -6 25 Rat 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C 8394362
10171 6845 18 None -5 6 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8394987
272 6845 18 None -5 6 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8394987
CHEMBL274384 6845 18 None -5 6 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC 8394987
10531 8202 21 None -23 24 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8226867
121 8202 21 None -23 24 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8226867
888 8202 21 None -23 24 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8226867
CHEMBL1732 8202 21 None -23 24 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8226867
DB00320 8202 21 None -23 24 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8226867
154 9138 0 None -12 4 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 3 1 2 2.9 CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
638252 9138 0 None -12 4 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 323 3 1 2 2.9 CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
1212 8443 50 None -15 65 Rat 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 7908055
204 8443 50 None -15 65 Rat 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 7908055
3372 8443 50 None -15 65 Rat 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 7908055
CHEMBL726 8443 50 None -15 65 Rat 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 7908055
DB00623 8443 50 None -15 65 Rat 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 7908055
107 6929 121 None -9 31 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394987
1833 6929 121 None -9 31 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394987
CHEMBL8165 6929 121 None -9 31 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394987
4106 9280 22 None -15 33 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394987
5358812 9280 22 None -15 33 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394987
89 9280 22 None -15 33 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394987
CHEMBL93240 9280 22 None -15 33 Mouse 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394987
122 8219 9 None 1 11 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
156314 8219 9 None 1 11 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
CHEMBL1332062 8219 9 None 1 11 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
5 6927 72 None -11 53 Mouse 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394987
5202 6927 72 None -11 53 Mouse 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394987
CHEMBL39 6927 72 None -11 53 Mouse 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394987
DB08839 6927 72 None -11 53 Mouse 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8394987
279 8442 26 None 1 17 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 7908055
49381 8442 26 None 1 17 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 7908055
CHEMBL63756 8442 26 None 1 17 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 0 0 3 3.1 CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 7908055
283 9904 57 None -4 12 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 9298538
4847 9904 57 None -4 12 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 9298538
CHEMBL18331 9904 57 None -4 12 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 5 0 5 3.3 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 9298538
2865 10915 73 None -12 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 15821958
59 10915 73 None -12 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 15821958
60854 10915 73 None -12 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 15821958
CHEMBL708 10915 73 None -12 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 15821958
DB00246 10915 73 None -12 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 15821958
103 10925 61 None -6 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 15821958
2875 10925 61 None -6 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 15821958
5736 10925 61 None -6 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 15821958
CHEMBL285802 10925 61 None -6 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 15821958
DB09225 10925 61 None -6 53 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 15821958
2389 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 15821958
2389 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 9720804
5073 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 15821958
5073 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 9720804
96 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 15821958
96 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 9720804
CHEMBL85 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 15821958
CHEMBL85 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 9720804
DB00734 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 15821958
DB00734 10104 118 None -8 66 Human 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 9720804
133 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 11414657
133 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8226867
133 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9298538
1723 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 11414657
1723 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8226867
1723 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9298538
28693 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 11414657
28693 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8226867
28693 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9298538
CHEMBL19215 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 11414657
CHEMBL19215 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8226867
CHEMBL19215 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9298538
DB13520 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 11414657
DB13520 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8226867
DB13520 9274 52 None -10 43 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9298538
2105 9828 37 None -1 32 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 8394362
47811 9828 37 None -1 32 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 8394362
48 9828 37 None -1 32 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 8394362
CHEMBL531 9828 37 None -1 32 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 8394362
DB01186 9828 37 None -1 32 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 8394362
1588 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8394362
1588 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
28864 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8394362
28864 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
43 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8394362
43 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
CHEMBL157138 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8394362
CHEMBL157138 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
DB00589 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8394362
DB00589 9105 27 None -6 44 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 8397408
103 10925 61 None -2 53 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 7908055
2875 10925 61 None -2 53 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 7908055
5736 10925 61 None -2 53 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 7908055
CHEMBL285802 10925 61 None -2 53 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 7908055
DB09225 10925 61 None -2 53 Rat 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 7908055
5 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 11414657
5 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 12527336
5 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8226867
5 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9298538
5 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9720804
5202 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 11414657
5202 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 12527336
5202 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8226867
5202 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9298538
5202 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9720804
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 11414657
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 12527336
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8226867
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9298538
CHEMBL39 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9720804
DB08839 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 11414657
DB08839 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 12527336
DB08839 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8226867
DB08839 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9298538
DB08839 6927 72 None -3 53 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9720804
107 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 11414657
107 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8226867
107 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 9298538
1833 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 11414657
1833 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8226867
1833 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 9298538
CHEMBL8165 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 11414657
CHEMBL8165 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8226867
CHEMBL8165 6929 121 None -3 31 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 9298538
4106 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 11414657
4106 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8226867
4106 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9298538
4106 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9720804
5358812 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 11414657
5358812 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8226867
5358812 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9298538
5358812 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9720804
89 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 11414657
89 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8226867
89 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9298538
89 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9720804
CHEMBL93240 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 11414657
CHEMBL93240 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8226867
CHEMBL93240 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9298538
CHEMBL93240 9280 22 None -4 33 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9720804
107 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394362
107 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8397408
1833 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394362
1833 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8397408
CHEMBL8165 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8394362
CHEMBL8165 6929 121 None -1 31 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8397408
1809 6922 32 None -12 37 Mouse 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394987
4 6922 32 None -12 37 Mouse 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394987
CHEMBL18840 6922 32 None -12 37 Mouse 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394987
4106 9280 22 None -2 33 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394362
5358812 9280 22 None -2 33 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394362
89 9280 22 None -2 33 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394362
CHEMBL93240 9280 22 None -2 33 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8394362
101 10594 24 None -2 14 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 7908055
55752 10594 24 None -2 14 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 7908055
CHEMBL35057 10594 24 None -2 14 Rat 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 6 0 6 3.9 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 7908055
1809 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 11414657
1809 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8226867
1809 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
1809 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9720804
4 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 11414657
4 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8226867
4 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
4 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9720804
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 11414657
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8226867
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9298538
CHEMBL18840 6922 32 None -7 37 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9720804
1809 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394362
1809 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8397408
4 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394362
4 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8397408
CHEMBL18840 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8394362
CHEMBL18840 6922 32 None -2 37 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8397408