ArrestinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-ADTN	297	None	18	Human	Binding	pKi	None	-	6.00	-588	7	Unclassified	Guide to Pharmacology	179.1	0	3	3	0.91	NC1CCc2cc(O)c(O)cc2C1	https://pubmed.ncbi.nlm.nih.gov/1826762
(+)-butaclamol	746	3H-SCH23390	9	Human	Binding	pKi	=	27.00	7.57	-61	25	-	PDSP KiDatabase	361.2	0	1	2	4.84	CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1	-
(+)-butaclamol	746	None	9	Human	Binding	pKi	None	-	7.60	-61	25	Unclassified	Guide to Pharmacology	361.2	0	1	2	4.84	CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1	https://pubmed.ncbi.nlm.nih.gov/1826762
(-)-stepholidine	3691	None	40	Human	Binding	Ki	=	4.40	8.36	1	35	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	327.1	2	2	5	2.77	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	https://dx.doi.org/10.1016/j.bmc.2009.08.028
(-)-stepholidine	3691	3H-SCH23390	40	Human	Binding	pKi	=	4.40	8.36	1	35	-	PDSP KiDatabase	327.1	2	2	5	2.77	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	-
(1R,2S)-PHENYLPROPANOLAMINE	27120	3H-SCH23390	13	Human	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	245.47	6.61	3	6	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2013.12.024
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	0.50	9.30	3	6	Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2020.127305
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	247.00	6.61	3	6	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2013.12.024
2-(4'-Methylaminophenyl)Benzothiazole	220178	3H-SCH23390	0	Human	Binding	pKi	=	13.00	7.89	-6	7	-	PDSP KiDatabase	268.1	3	1	5	4.75	CNc1ccc(N=Nc2ccc3ncsc3c2)cc1	-
5-hydroxytryptamine	139	None	45	Human	Binding	pKi	None	-	5.50	-7244	61	Unclassified	Guide to Pharmacology	176.1	2	3	2	1.38	NCCc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/1826762
5-hydroxytryptamine	139	3H-SCH23390	45	Human	Binding	pKi	=	3000.00	5.52	-7244	61	-	PDSP KiDatabase	176.1	2	3	2	1.38	NCCc1c[nH]c2ccc(O)cc12	-
A77636	208	None	8	Human	Binding	Ki	=	3.02	8.52	1	27	PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	ChEMBL	329.2	2	3	4	3.25	NC[C@@H]1O[C@H](C23CC4CC(CC(C4)C2)C3)Cc2c1ccc(O)c2O	https://dx.doi.org/10.6019/CHEMBL5442175
ABT-594	219818	3H-SCH23390	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
ADTN, (+)	218719	3H-SCH23390	0	Human	Binding	pKi	=	909.00	6.04	-2	4	-	PDSP KiDatabase	226.2	0	2	2	1.35	O=C1CCCCCNC(=O)CCCCCN1	-
AMENTOFLAVONE	205483	3H-SCH23390	63	Human	Binding	pKi	=	10000.00	5.00	-275	33	-	PDSP KiDatabase	538.1	3	6	10	5.13	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	-
amisulpride	400	3H-SCH23390	72	Human	Binding	pKi	=	10000.00	5.00	-4365	53	-	PDSP KiDatabase	369.2	7	2	6	1.28	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC	-
amitriptyline	401	UNDEFINED	38	Human	Binding	pKi	=	170.00	6.77	-112	51	-	PDSP KiDatabase	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	-
amitriptyline	401	None	38	Human	Binding	pKi	=	6.77	8.17	-112	51	None	Drug Central	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	-
amitriptyline	401	None	38	Human	Binding	Ki	=	170.00	6.77	-112	51	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	https://dx.doi.org/10.1016/j.bmcl.2008.09.012

Showing 1 to 20 of 717 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)