ArrestinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[D-Tyr⁸]CYN 154806	1506	None	0	Human	Binding	pKi	=	-	5.15	-2238	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12616335
[L-Tyr⁸]CYN 154806	2375	None	0	Human	Binding	pKi	=	-	5.80	-281	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12616335
ARSENIC TRIOXIDE	197249	None	1	Rat	Binding	Kd	=	52.48	7.28	478	2	Displacement of [125I]SRIF14 from rat sst1 receptor from rat brain cortex membrane	ChEMBL	197.8	1	0	3	-2.19	O=[As][As+](=O)[O-]	https://dx.doi.org/10.1016/j.bmcl.2007.04.078
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8769372
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
BIM 23268	218833	UNDEFINED	0	Human	Binding	pKi	=	18.40	7.74	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BIM 23268	218833	125I-SOMATOSTATIN	0	Human	Binding	pKi	=	582.00	6.24	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BIM 23268	218833	125I-Tyr11-somatostatin-14	0	Human	Binding	pKi	=	18.40	7.74	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BN-81,644	697	None	5	Human	Binding	Ki	=	3700.00	5.43	-5888	4	Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-1) subtype	ChEMBL	426.3	8	3	2	7.02	CCCCC1(CCCC)N[C@@H](c2ncc(-c3ccccc3)[nH]2)Cc2c1[nH]c1ccccc21	https://dx.doi.org/10.1021/jm0108449
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8769372
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
CHEMBL102892	4627	None	0	Human	Binding	Ki	=	1800.00	5.75	-1047	2	Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-1) subtype	ChEMBL	396.2	3	3	2	6.07	c1ccc(-c2c[nH]c(C3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)cc1	https://dx.doi.org/10.1021/jm0108449
CHEMBL1076620	5539	None	0	Human	Binding	Kd	=	436.52	6.36	-194	2	Binding affinity to human SST1 receptor	ChEMBL	620.3	9	0	9	4.43	COC(=O)c1cc(C[C@@H](C)CN2C[C@@H](C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)[C@H]3CCCC[C@H]3C2)cc(C(=O)OC)c1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076621	5540	None	0	Human	Binding	Kd	=	933.25	6.03	-758	2	Binding affinity to human SST1 receptor	ChEMBL	620.3	9	0	9	4.43	COC(=O)c1cc(C[C@H](C)CN2C[C@@H](C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)[C@H]3CCCC[C@H]3C2)cc(C(=O)OC)c1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076622	5541	None	0	Human	Binding	Kd	=	1380.38	5.86	-407	7	Binding affinity to human SST1 receptor	ChEMBL	550.3	6	0	5	5.68	Cc1nc2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2o1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076622	5541	None	0	Rat	Binding	Kd	=	457.09	6.34	-134	7	Displacement of [125I]SRIF-14 from rat cortex membrane SST1 receptor	ChEMBL	550.3	6	0	5	5.68	Cc1nc2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2o1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076627	5542	None	0	Human	Binding	Kd	=	39.81	7.40	2	2	Binding affinity to human SST1 receptor	ChEMBL	549.3	6	0	5	5.19	Cc1cn2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2n1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076652	5544	None	0	Human	Binding	Kd	=	489.78	6.31	-3	2	Binding affinity to human SST1 receptor	ChEMBL	548.3	7	0	7	4.73	CC(Cc1ccc2c(c1)OCO2)CN1C[C@H](C(=O)N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)C[C@@H]2CCCC[C@@H]21	https://dx.doi.org/10.1016/j.bmcl.2010.01.063

Showing 1 to 20 of 804 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)