ArrestinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Phaa¹,D-Tyr(Et)²,Lys⁶,des-Gly⁹]AVP	3089	None	0	Human	Binding	pKi	None	-	7.50	-31	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
[Phaa¹,D-Tyr(Et)²,Val⁴,Lys⁶,Tyr-NH₂⁸,des-Gly⁹]AVP	3090	None	0	Human	Binding	pKi	None	-	6.10	-281	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
[Phaa¹,D-Tyr(Me)²,Arg⁶,Tyr-NH₂⁹]AVP	3091	None	0	Human	Binding	pKi	None	-	8.00	-12	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
[Phaa¹,D-Tyr²,Val⁴,Arg⁶,Arg-NH₂⁹]AVP	3092	None	0	Human	Binding	pKi	None	-	7.80	-25	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
[tBaa¹,D-Tyr(Et)²,Val⁴,Lys⁶,Arg-NH₂⁸,des-Gly⁹]AVP	3760	None	0	Human	Binding	pKi	None	-	6.40	-501	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
[Val⁴]AVP	3970	None	0	Human	Binding	pKi	None	-	9.00	3	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12446593
arginine vasotocin	466	None	0	Human	Binding	pKi	=	-	8.00	-25	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9322919
Atosiban	218972	3H-AVP	0	Human	Binding	pKi	=	657.00	6.18	-11	5	-	PDSP KiDatabase	993.4	18	11	15	-3.04	CCOc1ccc(CC2NC(=O)CCSSCC(C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C(C)CC)NC2=O)cc1	-
Atosiban	218972	None	0	Human	Binding	pKi	=	7.36	8.13	-11	5	Binding affinity to human vasopressin V1b receptor	Drug Central	993.4	18	11	15	-3.04	CCOc1ccc(CC2NC(=O)CCSSCC(C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C(C)CC)NC2=O)cc1	-
atosiban	518	None	30	Human	Binding	Ki	=	44.00	7.36	-114	5	Binding affinity to human vasopressin V1b receptor	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmcl.2007.11.008
atosiban	518	None	30	Human	Binding	pKi	None	-	6.40	-114	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12660315
atosiban	518	None	30	Human	Binding	pKi	None	-	6.40	-114	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/14722330
AVP	218566	3H-AVP	0	Human	Binding	pKi	=	0.59	9.23	-1	10	-	PDSP KiDatabase	1083.4	19	14	16	-5.40	NC(=O)CCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC1=O	-
AVP	218566	None	0	Human	Binding	pKi	=	9.31	8.03	-1	10	Displacement of [3H]-AVP from human vasopressin V1b receptor expressed in CHO cells after 30 mins	Drug Central	1083.4	19	14	16	-5.40	NC(=O)CCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC1=O	-
AVP	218566	3H-AVP	0	Rat	Binding	pKi	=	0.23	9.64	1	10	-	PDSP KiDatabase	1083.4	19	14	16	-5.40	NC(=O)CCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC1=O	-
AVP	218566	None	0	Rat	Binding	pKi	=	9.54	8.02	1	10	Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in At-T20 cells	Drug Central	1083.4	19	14	16	-5.40	NC(=O)CCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC1=O	-
CHEMBL1161978	10319	None	0	Human	Binding	Ki	=	100.00	7.00	-1122	3	Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells	ChEMBL	2057.7	46	18	25	6.04	CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O	https://dx.doi.org/10.1021/jm061404q
CHEMBL1223631	16030	None	0	Human	Binding	IC50	=	22000.00	4.66	-	1	Displacement of [3H]AVP from human vasopresin3 receptor expressed in CHO cells	ChEMBL	475.3	9	1	7	2.22	CN1CCN(CCOc2ccc3nc(-c4ccccc4)n(CC(=O)NCC4CC4)c(=O)c3c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2010.07.118
CHEMBL1223632	16031	None	0	Human	Binding	IC50	=	1700.00	5.77	-	1	Displacement of [3H]AVP from human vasopresin3 receptor expressed in CHO cells	ChEMBL	489.3	10	1	7	2.61	CN1CCN(CCCOc2ccc3nc(-c4ccccc4)n(CC(=O)NCC4CC4)c(=O)c3c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2010.07.118
CHEMBL1223633	16032	None	0	Human	Binding	IC50	=	4800.00	5.32	-	1	Displacement of [3H]AVP from human vasopresin3 receptor expressed in CHO cells	ChEMBL	503.3	11	1	7	3.00	CN1CCN(CCCCOc2ccc3nc(-c4ccccc4)n(CC(=O)NCC4CC4)c(=O)c3c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2010.07.118

Showing 1 to 20 of 476 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)