Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

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weight		 Rot
Bonds		 H don

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 DOI
5803 394 21 None -2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
854189 394 21 None -2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
CHEMBL594671 394 21 None -2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
46235794 162935 0 None 2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4174307 162935 0 None 2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
67209751 162169 0 None -3 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4162307 162169 0 None -3 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
117898644 163097 0 None -3 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4177037 163097 0 None -3 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
145953626 162511 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167577 162511 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145953603 162480 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 432 4 1 5 4.3 C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167161 162480 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 432 4 1 5 4.3 C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
145953670 162562 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4168456 162562 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
162666399 182385 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 468 6 2 4 3.8 CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O 10.1016/j.bmcl.2020.127460
CHEMBL4785193 182385 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 468 6 2 4 3.8 CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O 10.1016/j.bmcl.2020.127460
57520598 1812 33 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00855
8417 1812 33 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00855
CHEMBL3353541 1812 33 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00855
DB15406 1812 33 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00855
145951537 162709 0 None 3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4170829 162709 0 None 3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
53302677 162847 1 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4172928 162847 1 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
67258265 162728 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171128 162728 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145957026 162208 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4162808 162208 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.8b00855
117898634 162395 0 None -5 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4165748 162395 0 None -5 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
145971768 163121 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 448 4 1 4 5.2 N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4177359 163121 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 448 4 1 4 5.2 N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145971768 163121 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 448 4 1 4 5.2 N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4177359 163121 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 448 4 1 4 5.2 N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145954653 162638 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 420 5 1 5 4.1 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4169673 162638 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 420 5 1 5 4.1 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
53302677 162847 1 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmcl.2020.127460
CHEMBL4172928 162847 1 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmcl.2020.127460
145951076 162973 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 408 4 1 5 4.3 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4175033 162973 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 408 4 1 5 4.3 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145954653 162638 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 420 5 1 5 4.1 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4169673 162638 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 420 5 1 5 4.1 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
145953670 162562 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4168456 162562 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
5803 394 21 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
854189 394 21 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
CHEMBL594671 394 21 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmc.2018.09.015
67210172 162458 0 None -5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4166818 162458 0 None -5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
67209218 162880 0 None -5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4173387 162880 0 None -5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
67209297 162798 0 None -7 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4172349 162798 0 None -7 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145952068 162863 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 477 4 1 4 5.1 COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4173130 162863 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 477 4 1 4 5.1 COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145950070 162766 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 438 5 1 6 4.3 COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171813 162766 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 438 5 1 6 4.3 COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
145949561 162940 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 409 5 1 5 4.3 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4174384 162940 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 409 5 1 5 4.3 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1 10.1021/acs.jmedchem.8b00855
145954073 162493 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167352 162493 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
67209297 162798 0 None 7 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4172349 162798 0 None 7 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
53302677 162847 1 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1021/acs.jmedchem.8b00855
CHEMBL4172928 162847 1 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1021/acs.jmedchem.8b00855
145955080 162630 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 465 5 1 4 5.6 CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4169498 162630 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 465 5 1 4 5.6 CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145952174 162998 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 447 3 1 3 5.1 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4175443 162998 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 447 3 1 3 5.1 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145954381 162575 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 530 6 1 5 6.9 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4168646 162575 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 530 6 1 5 6.9 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1 10.1021/acs.jmedchem.8b00855
145962491 162371 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 427 4 1 5 4.1 Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4165226 162371 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 427 4 1 5 4.1 Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145949561 162940 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 409 5 1 5 4.3 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4174384 162940 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 409 5 1 5 4.3 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1 10.1021/acs.jmedchem.8b00855
145956912 162052 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4160351 162052 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145952068 162863 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 477 4 1 4 5.1 COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4173130 162863 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 477 4 1 4 5.1 COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145959365 162000 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 497 5 1 4 5.5 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4159447 162000 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 497 5 1 4 5.5 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1 10.1021/acs.jmedchem.8b00855
145951076 162973 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 408 4 1 5 4.3 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4175033 162973 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 408 4 1 5 4.3 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145951986 162704 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4170748 162704 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
67209751 162169 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4162307 162169 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
117898634 162395 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4165748 162395 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
117898651 162893 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4173663 162893 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
117898644 163097 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4177037 163097 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
46235794 162935 0 None -2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4174307 162935 0 None -2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145951986 162704 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4170748 162704 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145952606 163000 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1 10.1021/acs.jmedchem.8b00855
CHEMBL4175455 163000 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1 10.1021/acs.jmedchem.8b00855
145954073 162493 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167352 162493 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145957346 161970 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4159019 161970 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
67210172 162458 0 None 5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4166818 162458 0 None 5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
67209218 162880 0 None 5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4173387 162880 0 None 5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145949794 162717 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4170872 162717 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145953603 162480 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 432 4 1 5 4.3 C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167161 162480 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 432 4 1 5 4.3 C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
145959365 162000 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 497 5 1 4 5.5 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4159447 162000 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 497 5 1 4 5.5 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1 10.1021/acs.jmedchem.8b00855
145958427 162104 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 409 4 1 6 3.7 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4161202 162104 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 409 4 1 6 3.7 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1 10.1021/acs.jmedchem.8b00855
138319694 163074 30 None -5 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4176503 163074 30 None -5 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145951370 162781 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 437 4 1 3 5.7 Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171999 162781 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 437 4 1 3 5.7 Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145952606 163000 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1 10.1021/acs.jmedchem.8b00855
CHEMBL4175455 163000 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1 10.1021/acs.jmedchem.8b00855
5803 394 21 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1021/acs.jmedchem.8b00855
854189 394 21 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1021/acs.jmedchem.8b00855
CHEMBL594671 394 21 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1021/acs.jmedchem.8b00855
145951370 162781 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 437 4 1 3 5.7 Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171999 162781 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 437 4 1 3 5.7 Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145956912 162052 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4160351 162052 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145959580 162337 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 443 4 1 4 5.7 Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1 10.1021/acs.jmedchem.8b00855
CHEMBL4164813 162337 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 443 4 1 4 5.7 Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1 10.1021/acs.jmedchem.8b00855
145949591 162721 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 471 5 1 4 5.5 COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F 10.1021/acs.jmedchem.8b00855
CHEMBL4170955 162721 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 471 5 1 4 5.5 COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F 10.1021/acs.jmedchem.8b00855
145951537 162709 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4170829 162709 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
53302677 162847 1 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4172928 162847 1 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
138319694 163074 30 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4176503 163074 30 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
67258265 162728 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171128 162728 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145952174 162998 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 447 3 1 3 5.1 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4175443 162998 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 447 3 1 3 5.1 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145957026 162208 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4162808 162208 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.8b00855
145958672 162116 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 457 4 1 3 6.0 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4161397 162116 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 457 4 1 3 6.0 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
138319694 163074 30 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4176503 163074 30 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
117898651 162893 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4173663 162893 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
145949794 162717 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4170872 162717 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
138319694 163074 30 None 5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4176503 163074 30 None 5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
162648013 179972 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 427 8 1 4 6.3 Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1 10.1016/j.bmcl.2020.127460
CHEMBL4746807 179972 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay
ChEMBL 427 8 1 4 6.3 Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1 10.1016/j.bmcl.2020.127460
145955080 162630 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 465 5 1 4 5.6 CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4169498 162630 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 465 5 1 4 5.6 CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1 10.1021/acs.jmedchem.8b00855
145953626 162511 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167577 162511 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145950070 162766 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 438 5 1 6 4.3 COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171813 162766 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 438 5 1 6 4.3 COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1 10.1021/acs.jmedchem.8b00855
145958672 162116 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 457 4 1 3 6.0 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4161397 162116 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 457 4 1 3 6.0 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145949591 162721 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 471 5 1 4 5.5 COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F 10.1021/acs.jmedchem.8b00855
CHEMBL4170955 162721 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 471 5 1 4 5.5 COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F 10.1021/acs.jmedchem.8b00855
145959580 162337 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 443 4 1 4 5.7 Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1 10.1021/acs.jmedchem.8b00855
CHEMBL4164813 162337 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 443 4 1 4 5.7 Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1 10.1021/acs.jmedchem.8b00855
145957346 161970 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4159019 161970 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
145962491 162371 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 427 4 1 5 4.1 Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4165226 162371 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay
ChEMBL 427 4 1 5 4.1 Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
46226274 202321 0 None - 1 Human 6.0 pIC50 = 6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 342 3 1 3 5.2 CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL610333 202321 0 None - 1 Human 6.0 pIC50 = 6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 342 3 1 3 5.2 CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
118719384 115524 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 384 5 1 2 3.8 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3352999 115524 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 384 5 1 2 3.8 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1 10.1021/jm5012885
68175794 115529 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 427 7 1 3 3.5 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353004 115529 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 427 7 1 3 3.5 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
118719385 115530 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 2 3 3.4 CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353005 115530 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 2 3 3.4 CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
46226177 199769 0 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 279 4 2 4 2.2 CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593826 199769 0 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 279 4 2 4 2.2 CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226178 199770 0 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 2 2 3.4 CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593827 199770 0 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 2 2 3.4 CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
847243 199918 12 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 252 3 1 3 3.0 O=C(Cc1ccc(Cl)cc1)Nc1nccs1 10.1016/j.bmcl.2009.11.112
CHEMBL594760 199918 12 None - 1 Human 4.0 pIC50 = 4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 252 3 1 3 3.0 O=C(Cc1ccc(Cl)cc1)Nc1nccs1 10.1016/j.bmcl.2009.11.112
46226356 199912 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 292 5 1 3 4.1 C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594738 199912 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 292 5 1 3 4.1 C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226144 199915 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 4 1 2 4.3 CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594746 199915 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 4 1 2 4.3 CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226383 202067 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 344 4 1 3 4.4 O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1 10.1016/j.bmcl.2009.11.112
CHEMBL608697 202067 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 344 4 1 3 4.4 O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1 10.1016/j.bmcl.2009.11.112
46226106 200122 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 225 3 1 1 2.8 CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2009.11.112
CHEMBL596153 200122 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 225 3 1 1 2.8 CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2009.11.112
77904272 115631 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353510 115631 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
70558275 115637 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 490 8 1 5 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353516 115637 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 490 8 1 5 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
89894240 115658 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 488 9 1 5 4.6 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3353539 115658 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 488 9 1 5 4.6 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
70559113 115629 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353502 115629 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
46226336 199955 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 4 1 3 4.1 O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2009.11.112
CHEMBL594998 199955 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 4 1 3 4.1 O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2009.11.112
46226312 201745 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 474 4 2 4 5.9 CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL606629 201745 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 474 4 2 4 5.9 CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
29369661 199882 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594537 199882 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
68176091 115597 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 442 8 0 3 4.2 COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353464 115597 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 442 8 0 3 4.2 COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
70556816 115601 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 441 7 1 3 3.0 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353468 115601 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 441 7 1 3 3.0 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
70561343 115638 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 490 8 2 5 4.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353517 115638 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 490 8 2 5 4.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
46226145 202193 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 4 1 2 4.3 CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609584 202193 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 4 1 2 4.3 CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70561241 115659 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 488 9 2 5 3.7 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3353540 115659 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 488 9 2 5 3.7 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
46226143 199914 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594745 199914 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
9095896 200066 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 1 3 4.5 Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1 10.1016/j.bmcl.2009.11.112
CHEMBL595715 200066 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 1 3 4.5 Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1 10.1016/j.bmcl.2009.11.112
68175951 115626 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 4 0 3 4.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353498 115626 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 4 0 3 4.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
89900352 115599 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 479 8 0 4 5.4 CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353466 115599 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 479 8 0 4 5.4 CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
89900321 115525 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 398 5 0 2 4.1 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353000 115525 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 398 5 0 2 4.1 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
70556487 115523 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 5 1 3 4.4 CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3352998 115523 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 5 1 3 4.4 CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226360 202159 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 3 1 3 4.0 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1 10.1016/j.bmcl.2009.11.112
CHEMBL609291 202159 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 3 1 3 4.0 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1 10.1016/j.bmcl.2009.11.112
46226254 202231 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.2 CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609861 202231 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.2 CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226290 202232 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 333 3 1 4 4.4 CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609863 202232 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 333 3 1 4 4.4 CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226291 202496 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 376 3 1 3 5.6 CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL611340 202496 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 376 3 1 3 5.6 CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70565254 115648 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 476 9 2 4 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1 10.1021/jm5012885
CHEMBL3353528 115648 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 476 9 2 4 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1 10.1021/jm5012885
68176356 115604 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 469 9 1 3 3.8 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353471 115604 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 469 9 1 3 3.8 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
68176096 115603 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 469 7 0 3 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353470 115603 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 469 7 0 3 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
46226308 199911 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 351 4 1 4 4.6 CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1 10.1016/j.bmcl.2009.11.112
CHEMBL594737 199911 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 351 4 1 4 4.6 CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1 10.1016/j.bmcl.2009.11.112
46226309 201289 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 393 4 1 5 4.4 CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL604059 201289 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 393 4 1 5 4.4 CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226385 199996 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 311 4 1 4 3.5 O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1 10.1016/j.bmcl.2009.11.112
CHEMBL595235 199996 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 311 4 1 4 3.5 O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1 10.1016/j.bmcl.2009.11.112
89894379 133461 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 482 9 1 4 4.5 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3706688 133461 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 482 9 1 4 4.5 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
46226235 202122 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.2 CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL608991 202122 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.2 CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70556496 115643 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 9 1 3 4.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353523 115643 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 9 1 3 4.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
46226251 202397 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 322 4 1 3 4.8 Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C 10.1016/j.bmcl.2009.11.112
CHEMBL610741 202397 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 322 4 1 3 4.8 Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C 10.1016/j.bmcl.2009.11.112
36477073 199924 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 363 4 1 4 4.6 CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594770 199924 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 363 4 1 4 4.6 CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226255 199775 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 319 4 1 4 4.0 CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593839 199775 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 319 4 1 4 4.0 CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
39725404 199868 1 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 352 5 1 5 4.0 COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1 10.1016/j.bmcl.2009.11.112
CHEMBL594505 199868 1 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 352 5 1 5 4.0 COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1 10.1016/j.bmcl.2009.11.112
46226163 199925 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594771 199925 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
135971436 199682 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 3 1 3 2.8 CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593121 199682 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 310 3 1 3 2.8 CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226164 199750 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 2 2 3.4 CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593607 199750 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 2 2 3.4 CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
2520490 199681 2 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 296 3 1 3 3.3 CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593120 199681 2 None - 1 Human 5.7 pIC50 = 5.7 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 296 3 1 3 3.3 CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
89894269 133462 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 454 7 1 4 3.7 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3706689 133462 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 454 7 1 4 3.7 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
46226161 199721 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593435 199721 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226311 199870 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 441 4 1 6 3.8 CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594507 199870 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 441 4 1 6 3.8 CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
68176357 115611 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 505 9 1 4 3.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353478 115611 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 505 9 1 4 3.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
89900347 115598 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 451 6 0 4 4.6 CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353465 115598 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 451 6 0 4 4.6 CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
70559604 115635 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353514 115635 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
46226162 199722 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 278 4 1 3 3.7 CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593436 199722 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 278 4 1 3 3.7 CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226295 199807 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 432 5 1 3 6.8 CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594074 199807 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 432 5 1 3 6.8 CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70559551 115634 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 518 8 1 4 5.4 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353513 115634 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 518 8 1 4 5.4 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
89894353 115656 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 516 9 1 4 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3353536 115656 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 516 9 1 4 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
89900371 115615 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 519 10 1 4 3.5 CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353481 115615 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 519 10 1 4 3.5 CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
89900327 115526 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 3 4.7 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353001 115526 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 3 4.7 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
70558376 115616 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 442 7 1 3 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353482 115616 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 442 7 1 3 3.6 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
88757504 115642 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353522 115642 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
46226182 202230 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 344 4 1 3 5.3 CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609852 202230 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 344 4 1 3 5.3 CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70558485 115618 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 4.6 CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353484 115618 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 4.6 CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
70557254 115639 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 507 8 1 6 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353518 115639 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 507 8 1 6 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
118719612 115512 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 4 4.3 COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl 10.1021/jm5012885
CHEMBL3352828 115512 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 4 4.3 COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl 10.1021/jm5012885
68176101 115528 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 456 7 1 4 4.1 CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353003 115528 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 456 7 1 4 4.1 CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
118719611 115623 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 406 4 0 2 4.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12 10.1021/jm5012885
CHEMBL3353491 115623 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 406 4 0 2 4.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12 10.1021/jm5012885
118719617 115627 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 446 4 0 3 5.5 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12 10.1021/jm5012885
CHEMBL3353499 115627 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 446 4 0 3 5.5 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12 10.1021/jm5012885
70557757 115645 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 9 1 3 4.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1 10.1021/jm5012885
CHEMBL3353525 115645 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 9 1 3 4.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1 10.1021/jm5012885
118719609 115609 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 497 8 1 4 4.3 CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353476 115609 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 497 8 1 4 4.3 CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226293 202194 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 386 4 1 5 4.0 CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609586 202194 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 386 4 1 5 4.0 CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70556905 115633 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353512 115633 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
70556713 115617 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 4.2 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353483 115617 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 4.2 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
70559086 115653 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 1 5 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353533 115653 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 1 5 5.1 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226179 202031 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 278 4 1 3 3.7 CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL608384 202031 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 278 4 1 3 3.7 CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70559096 115600 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 9 0 4 4.5 COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353467 115600 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 9 0 4 4.5 COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
46226310 199869 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 406 4 1 5 4.3 CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1 10.1016/j.bmcl.2009.11.112
CHEMBL594506 199869 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 406 4 1 5 4.3 CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1 10.1016/j.bmcl.2009.11.112
89900361 115607 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 539 9 0 4 4.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353474 115607 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 539 9 0 4 4.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
70562777 115654 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 2 5 4.2 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353534 115654 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 2 5 4.2 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
70557843 115619 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353485 115619 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
68175817 115610 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 505 9 1 4 3.1 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353477 115610 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 505 9 1 4 3.1 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
46226234 202396 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.5 CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL610740 202396 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 362 4 1 3 5.5 CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
89901463 115614 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 547 10 1 5 4.1 CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353480 115614 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 547 10 1 5 4.1 CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
68176095 115602 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 7 1 3 3.3 CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353469 115602 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 7 1 3 3.3 CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
89900348 115624 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 423 5 0 3 4.0 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12 10.1021/jm5012885
CHEMBL3353492 115624 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 423 5 0 3 4.0 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12 10.1021/jm5012885
46226386 199876 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 1 4 2.8 O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1 10.1016/j.bmcl.2009.11.112
CHEMBL594528 199876 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 277 4 1 4 2.8 O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1 10.1016/j.bmcl.2009.11.112
46226333 199919 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 266 3 1 3 3.5 C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594761 199919 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 266 3 1 3 3.5 C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
89900346 115606 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 511 7 0 4 3.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353473 115606 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 511 7 0 4 3.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
68176013 115527 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 6 0 2 4.5 CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
CHEMBL3353002 115527 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 412 6 0 2 4.5 CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1 10.1021/jm5012885
70564780 115652 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 503 9 2 4 4.8 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353532 115652 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 503 9 2 4 4.8 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226142 199913 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594744 199913 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
3420 3448 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
46226252 3448 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
CHEMBL594525 3448 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
46226292 199917 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 354 4 1 4 5.3 CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1 10.1016/j.bmcl.2009.11.112
CHEMBL594758 199917 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 354 4 1 4 5.3 CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1 10.1016/j.bmcl.2009.11.112
70557810 115651 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353531 115651 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 498 9 1 4 5.0 CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226361 199949 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 324 3 1 3 4.4 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1 10.1016/j.bmcl.2009.11.112
CHEMBL594974 199949 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 324 3 1 3 4.4 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1 10.1016/j.bmcl.2009.11.112
46226334 202233 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 280 4 1 3 3.9 CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL609870 202233 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 280 4 1 3 3.9 CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226358 202588 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 298 3 1 3 3.9 CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL611948 202588 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 298 3 1 3 3.9 CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
89900356 115628 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 3 4.7 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1 10.1021/jm5012885
CHEMBL3353500 115628 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 426 5 0 3 4.7 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1 10.1021/jm5012885
70556743 115630 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 7 1 5 3.1 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12 10.1021/jm5012885
CHEMBL3353505 115630 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 7 1 5 3.1 CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12 10.1021/jm5012885
70558482 115625 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 396 4 0 3 4.3 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1 10.1021/jm5012885
CHEMBL3353495 115625 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 396 4 0 3 4.3 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1 10.1021/jm5012885
68176100 115605 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 8 1 3 3.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
CHEMBL3353472 115605 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 455 8 1 3 3.4 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1 10.1021/jm5012885
4964042 202275 4 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 327 4 2 2 4.6 CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL610060 202275 4 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 327 4 2 2 4.6 CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226146 199712 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593351 199712 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226335 199920 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 5 1 3 4.3 CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594762 199920 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 5 1 3 4.3 CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70559021 115644 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 1 3 4.7 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1 10.1021/jm5012885
CHEMBL3353524 115644 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 504 9 1 3 4.7 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1 10.1021/jm5012885
25479840 199719 1 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593433 199719 1 None - 1 Human 4.3 pIC50 = 4.3 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 288 4 1 2 4.1 CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70557930 115650 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 532 9 1 4 5.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353530 115650 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 532 9 1 4 5.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
46226160 202543 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL611632 202543 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 289 4 1 3 3.5 CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226180 200182 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL596580 200182 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 295 4 1 4 3.6 CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70559585 115640 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353520 115640 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
118719610 115622 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 452 6 0 3 5.3 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1 10.1021/jm5012885
CHEMBL3353490 115622 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 452 6 0 3 5.3 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1 10.1021/jm5012885
46226337 202066 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 5 1 3 4.6 CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL608696 202066 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 5 1 3 4.6 CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70557795 115632 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353511 115632 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 470 7 1 4 5.1 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
70564643 115636 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 489 8 2 4 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353515 115636 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 489 8 2 4 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
70559574 115641 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
CHEMBL3353521 115641 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 471 7 1 5 4.5 CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12 10.1021/jm5012885
5803 394 21 None -2 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
854189 394 21 None -2 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
CHEMBL594671 394 21 None -2 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 10.1016/j.bmcl.2009.11.112
12861 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 10.1016/j.bmcl.2009.11.112
46226294 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 10.1016/j.bmcl.2009.11.112
CHEMBL607315 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 10.1016/j.bmcl.2009.11.112
46226275 199709 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 386 3 1 3 5.3 CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593344 199709 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 386 3 1 3 5.3 CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226273 202494 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 326 3 1 3 4.7 CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL611338 202494 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 326 3 1 3 4.7 CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226253 202495 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 328 4 1 3 4.8 CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL611339 202495 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 328 4 1 3 4.8 CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226272 201936 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 337 5 2 4 3.3 CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL607691 201936 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 337 5 2 4 3.3 CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70559626 115649 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 493 9 1 5 4.3 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1 10.1021/jm5012885
CHEMBL3353529 115649 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 493 9 1 5 4.3 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1 10.1021/jm5012885
89900365 115608 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 567 9 0 5 4.8 CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353475 115608 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 567 9 0 5 4.8 CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
89900378 115612 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 533 9 1 5 3.8 CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353479 115612 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 533 9 1 5 3.8 CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
68175329 115621 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 446 6 0 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1 10.1021/jm5012885
CHEMBL3353489 115621 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 446 6 0 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1 10.1021/jm5012885
70558983 115647 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 476 9 1 4 4.5 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1 10.1021/jm5012885
CHEMBL3353527 115647 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 476 9 1 4 4.5 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1 10.1021/jm5012885
68175946 115620 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 406 5 0 2 3.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1 10.1021/jm5012885
CHEMBL3353487 115620 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 406 5 0 2 3.8 CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1 10.1021/jm5012885
46226236 199802 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 350 4 1 3 5.5 CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594052 199802 1 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 350 4 1 3 5.5 CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46226271 199816 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 338 5 2 4 3.9 CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594140 199816 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 338 5 2 4 3.9 CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
2397905 199874 2 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 1 3 4.5 Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1 10.1016/j.bmcl.2009.11.112
CHEMBL594524 199874 2 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 1 3 4.5 Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1 10.1016/j.bmcl.2009.11.112
4307629 202341 47 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 4 1 3 4.2 CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL610463 202341 47 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 294 4 1 3 4.2 CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
46225340 199756 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 0 3 4.2 CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL593733 199756 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 308 4 0 3 4.2 CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
70562873 115646 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 475 9 2 3 4.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1 10.1021/jm5012885
CHEMBL3353526 115646 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 475 9 2 3 4.2 Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1 10.1021/jm5012885
46226382 199958 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 338 3 1 3 4.8 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1 10.1016/j.bmcl.2009.11.112
CHEMBL595000 199958 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 338 3 1 3 4.8 O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1 10.1016/j.bmcl.2009.11.112
46226338 199843 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 5 1 3 4.3 O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
CHEMBL594302 199843 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production
ChEMBL 306 5 1 3 4.3 O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.11.112
57520598 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
8417 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
CHEMBL3353541 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
DB15406 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
70566934 115657 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 487 9 2 4 4.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
CHEMBL3353538 115657 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 487 9 2 4 4.3 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12 10.1021/jm5012885
70556909 115655 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 521 9 1 6 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
CHEMBL3353535 115655 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization
ChEMBL 521 9 1 6 4.9 CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12 10.1021/jm5012885
1058 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
176 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
21980959 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
4211 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
CHEMBL539 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
DB03166 254 85 None 3 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 60 0 1 1 0.1 CC(=O)O None
10107 3883 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
137321147 3883 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
10107 3883 0 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
137321147 3883 0 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
6500 34 115 None -47 2 Human 2.6 pEC50 = 2.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
81326 34 115 None -47 2 Human 2.6 pEC50 = 2.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
CHEMBL4516837 34 115 None -47 2 Human 2.6 pEC50 = 2.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
1061 3044 0 None -50 2 Human 2.9 pEC50 = 2.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
7991 3044 0 None -50 2 Human 2.9 pEC50 = 2.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
CHEMBL268736 3044 0 None -50 2 Human 2.9 pEC50 = 2.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
DB02406 3044 0 None -50 2 Human 2.9 pEC50 = 2.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
1059 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
1059 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12684041
1059 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
1059 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
264 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
264 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12684041
264 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
264 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
CHEMBL14227 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
CHEMBL14227 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12684041
CHEMBL14227 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
CHEMBL14227 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
DB03568 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
DB03568 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12684041
DB03568 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
DB03568 750 81 None -7 3 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
125468 2102 0 None - 1 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 1.0 C/C(=C\C)/C(=O)O 21220428
6499 2102 0 None - 1 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 1.0 C/C(=C\C)/C(=O)O 21220428
CHEMBL52416 2102 0 None - 1 Human 3.8 pEC50 = 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 1.0 C/C(=C\C)/C(=O)O 21220428
1058 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
1058 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
1058 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
1058 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
176 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
176 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
176 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
176 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
21980959 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
21980959 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
21980959 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
21980959 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
4211 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
4211 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
4211 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
4211 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
CHEMBL539 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
CHEMBL539 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
CHEMBL539 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
CHEMBL539 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
DB03166 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
DB03166 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12684041
DB03166 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
DB03166 254 85 None 3 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
1032 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
1032 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12684041
1032 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
1032 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
1062 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
1062 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12684041
1062 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
1062 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
CHEMBL14021 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
CHEMBL14021 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12684041
CHEMBL14021 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
CHEMBL14021 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
DB03766 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
DB03766 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12684041
DB03766 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
DB03766 3185 78 None -8 2 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
5803 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 18818303
5803 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 21498659
854189 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 18818303
854189 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 21498659
CHEMBL594671 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 18818303
CHEMBL594671 394 21 None -2 2 Human 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 4 1 3 4.2 CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C 21498659
3420 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 18818303
3420 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 23066016
46226252 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 18818303
46226252 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 23066016
CHEMBL594525 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 18818303
CHEMBL594525 3448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 312 4 1 3 4.3 CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C 23066016
10107 3883 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
137321147 3883 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
6488 1016 0 None - 1 Rat 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 474 8 1 4 5.9 OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1 23589301
67209274 1016 0 None - 1 Rat 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 474 8 1 4 5.9 OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1 23589301
1060 2089 74 None -11 3 Human 3.5 pEC50 None 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12711604
6590 2089 74 None -11 3 Human 3.5 pEC50 None 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12711604
CHEMBL108778 2089 74 None -11 3 Human 3.5 pEC50 None 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12711604
DB02531 2089 74 None -11 3 Human 3.5 pEC50 None 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12711604
12861 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2
Guide to Pharmacology 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 20005104
46226294 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2
Guide to Pharmacology 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 20005104
CHEMBL607315 1199 26 None - 1 Human 6.2 pIC50 = 6.2 Functional
Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2
Guide to Pharmacology 384 4 1 3 6.2 CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3 20005104
57520598 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 25380412
57520598 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 26852904
8417 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 25380412
8417 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 26852904
CHEMBL3353541 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 25380412
CHEMBL3353541 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 26852904
DB15406 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 25380412
DB15406 1812 33 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.
Guide to Pharmacology 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 26852904
12655 3884 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Measuring antagonism of agonist-induced GTP&gamma;S incorporation by liquid scintillation spectroscopy.Measuring antagonism of agonist-induced GTP&gamma;S incorporation by liquid scintillation spectroscopy.
Guide to Pharmacology 419 8 2 5 2.7 O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3 None
168433292 3884 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Measuring antagonism of agonist-induced GTP&gamma;S incorporation by liquid scintillation spectroscopy.Measuring antagonism of agonist-induced GTP&gamma;S incorporation by liquid scintillation spectroscopy.
Guide to Pharmacology 419 8 2 5 2.7 O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3 None
12655 3884 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.
Guide to Pharmacology 419 8 2 5 2.7 O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3 None
168433292 3884 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.
Guide to Pharmacology 419 8 2 5 2.7 O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3 None
53308747 810 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 399 7 2 2 4.1 OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F 23066016
6487 810 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 399 7 2 2 4.1 OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F 23066016


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

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 Smiles

 DOI
CHEMBL5275861 193872 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 286 4 2 4 2.1 O=c1cc(CCCCCl)c2c(=O)[nH]c(=S)[nH]c2o1 10.1039/d2md00076h
137633536 156295 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL4065397 156295 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL5284951 194273 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 270 4 2 4 0.7 O=c1[nH]c(=O)c2c(CCCCCl)cc(=O)oc2[nH]1 10.1039/d2md00076h
CHEMBL5270112 193620 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA2 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 252 3 2 4 1.9 CCCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 10.1039/d2md00076h
57520598 1812 33 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
8417 1812 33 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
CHEMBL3353541 1812 33 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
DB15406 1812 33 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry
ChEMBL 484 8 1 4 5.1 OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl 10.1021/jm5012885
145951537 162709 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4170829 162709 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 537 10 1 7 6.0 COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
145957346 161970 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4159019 161970 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 419 5 1 4 4.7 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
67209751 162169 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4162307 162169 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 505 10 1 6 6.0 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
117898644 163097 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4177037 163097 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 515 10 1 7 5.7 CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
53302677 162847 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4172928 162847 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 474 8 1 4 5.9 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
67209297 162798 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4172349 162798 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 422 7 1 5 4.3 CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
138319694 163074 30 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4176503 163074 30 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 442 4 1 5 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
117898634 162395 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
CHEMBL4165748 162395 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 479 10 1 6 5.5 COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1 10.1016/j.bmc.2018.09.015
67209218 162880 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4173387 162880 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 406 7 1 4 5.1 CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145951986 162704 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4170748 162704 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 453 5 1 4 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
145953670 162562 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4168456 162562 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 424 4 1 4 5.0 Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
67210172 162458 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4166818 162458 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 440 8 1 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1 10.1016/j.bmc.2018.09.015
67258265 162728 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4171128 162728 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 435 5 1 3 5.4 COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1 10.1021/acs.jmedchem.8b00855
117898651 162893 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
CHEMBL4173663 162893 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 541 10 1 7 6.2 O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1 10.1016/j.bmc.2018.09.015
46235794 162935 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
CHEMBL4174307 162935 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method
ChEMBL 414 7 1 4 4.8 CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1 10.1016/j.bmc.2018.09.015
145953626 162511 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
CHEMBL4167577 162511 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry
ChEMBL 423 4 1 3 5.3 O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.8b00855
10107 3883 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for hFFA2.Binding affinity for hFFA2.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908
137321147 3883 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for hFFA2.Binding affinity for hFFA2.
Guide to Pharmacology 442 4 1 5 5.0 O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C 30247908