ArrestinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	BAY u9773	218707	3H-LTD4	0	Human	Binding	pKi	=	300.00	6.52	1	2	-	PDSP KiDatabase	472.2	17	3	4	6.66	CCCCC/C=C\C/C=C/C=C/C=C/[C@@H](Sc1ccc(C(=O)O)cc1)[C@@H](O)CCCC(=O)O	-
	CHEMBL4577928	175615	None	0	Human	Binding	IC50	=	4500.00	5.35	-	1	Inhibition of CysLT2 (unknown origin)	ChEMBL	412.1	5	3	6	1.47	O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2	https://dx.doi.org/10.1021/acsmedchemlett.8b00274
	ICI198615	1978	None	12	Human	Binding	pKd	=	-	5.20	-251188	3	Unclassified	Guide to Pharmacology	548.2	8	2	8	4.70	COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21	https://pubmed.ncbi.nlm.nih.gov/1329767
	LTD₄	2370	None	0	Human	Binding	pKd	=	-	8.35	-21	4	Unclassified	Guide to Pharmacology	496.3	20	5	6	3.43	CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/10851239
	LTD₄	2370	None	0	Human	Binding	pKi	=	-	7.70	-21	4	Unclassified	Guide to Pharmacology	496.3	20	5	6	3.43	CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9547367
	LTE₄	2371	None	24	Human	Binding	pKi	=	-	6.50	-125	5	Unclassified	Guide to Pharmacology	439.2	18	4	5	4.31	CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)O)[C@@H](O)CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9547367
	MK 571	218708	3H-LTD4	0	Human	Binding	pKi	=	1000.00	6.00	-95	2	-	PDSP KiDatabase	514.1	11	1	5	6.48	CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1	-
	montelukast	2592	None	44	Human	Binding	pKi	None	5.30	8.28	-2	21	None	Drug Central	585.2	12	2	4	8.95	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1	-
	Montelukast	218695	3H-LTD4	0	Human	Binding	pKi	=	5000.00	5.30	-2187	4	-	PDSP KiDatabase	473.2	7	2	3	7.89	CC(C)(O)c1ccccc1CCC(S)c1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1	-
	pranlukast	3162	None	53	Human	Binding	IC50	=	3620.00	5.44	-	11	Antagonist activity at human CysLT2 expressed in HEK293T cells assessed as inhibition of LTC4-induced effect preincubated for 30 mins prior to LTC4 addition by Aequorin luminescence assay	ChEMBL	481.2	9	2	7	4.63	O=C(Nc1cccc2c(=O)cc(-c3nnn[nH]3)oc12)c1ccc(OCCCCc2ccccc2)cc1	https://dx.doi.org/10.1021/acs.jmedchem.5b00741
	zafirlukast	4132	None	63	Human	Binding	IC50	=	7397.00	5.13	-776	14	Antagonist activity at human CysLT2 expressed in HEK293T cells assessed as inhibition of LTC4-induced effect preincubated for 30 mins prior to LTC4 addition by Aequorin luminescence assay	ChEMBL	575.2	8	2	7	5.70	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12	https://dx.doi.org/10.1021/acs.jmedchem.5b00741
	zafirlukast	4132	3H-LTD4	63	Human	Binding	pKi	=	1000.00	6.00	-776	14	-	PDSP KiDatabase	575.2	8	2	7	5.70	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12	-

Showing 1 to 12 of 12 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI