Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
10883396 | 3649 | 45 | None | -2 | 15 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |
5283560 | 3649 | 45 | None | -2 | 15 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |
911 | 3649 | 45 | None | -2 | 15 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |
CHEMBL225155 | 3649 | 45 | None | -2 | 15 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |
9593133 | 109116 | 6 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 468 | 6 | 1 | 9 | 3.5 | Clc1ccc(-c2ccc(/C=N/Nc3cc(N4CCOCC4)nc(N4CCOCC4)n3)o2)cc1 | nan | |
CHEMBL3213728 | 109116 | 6 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 468 | 6 | 1 | 9 | 3.5 | Clc1ccc(-c2ccc(/C=N/Nc3cc(N4CCOCC4)nc(N4CCOCC4)n3)o2)cc1 | nan | |
58344778 | 154537 | 0 | None | -6309 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs |
ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |
CHEMBL3902160 | 154537 | 0 | None | -6309 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs |
ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |
CHEMBL3990889 | 154537 | 0 | None | -6309 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs |
ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |
2113511 | 31619 | 30 | None | 10 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 324 | 5 | 0 | 4 | 2.5 | Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1 | nan | |
CHEMBL1404553 | 31619 | 30 | None | 10 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 324 | 5 | 0 | 4 | 2.5 | Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1 | nan | |
977094 | 22840 | 9 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 284 | 2 | 0 | 4 | 2.1 | COc1cc2c(cc1OC)C1=C(C#N)CCC(=O)N1CC2 | nan | |
CHEMBL1328358 | 22840 | 9 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 284 | 2 | 0 | 4 | 2.1 | COc1cc2c(cc1OC)C1=C(C#N)CCC(=O)N1CC2 | nan | |
658787 | 46686 | 23 | None | 9 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 324 | 2 | 1 | 4 | 3.4 | Clc1ccc2nc(N3CCNCC3)nc(-c3ccccc3)c2c1 | nan | |
CHEMBL1539075 | 46686 | 23 | None | 9 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 324 | 2 | 1 | 4 | 3.4 | Clc1ccc2nc(N3CCNCC3)nc(-c3ccccc3)c2c1 | nan | |
67194420 | 143012 | 0 | None | -31622 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs |
ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |
CHEMBL3894716 | 143012 | 0 | None | -31622 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs |
ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |
2056575 | 108730 | 8 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 421 | 3 | 0 | 4 | 4.5 | COc1cc2c(cc1OC)C1=C(C#N)CC/C(=N\C(=O)c3ccc(Cl)cc3)N1CC2 | nan | |
CHEMBL3208498 | 108730 | 8 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 421 | 3 | 0 | 4 | 4.5 | COc1cc2c(cc1OC)C1=C(C#N)CC/C(=N\C(=O)c3ccc(Cl)cc3)N1CC2 | nan | |
1891819 | 36490 | 8 | None | 7 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 431 | 6 | 2 | 7 | 3.7 | CC(C)CCNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
CHEMBL1447632 | 36490 | 8 | None | 7 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 431 | 6 | 2 | 7 | 3.7 | CC(C)CCNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
3093171 | 46078 | 13 | None | 1 | 4 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 423 | 8 | 2 | 6 | 1.9 | O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO | nan | |
CHEMBL1533401 | 46078 | 13 | None | 1 | 4 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 423 | 8 | 2 | 6 | 1.9 | O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO | nan | |
733831 | 32242 | 10 | None | -2 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 328 | 4 | 0 | 7 | 2.8 | CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O | nan | |
CHEMBL1409828 | 32242 | 10 | None | -2 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 328 | 4 | 0 | 7 | 2.8 | CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O | nan | |
4669891 | 51809 | 16 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 386 | 3 | 0 | 4 | 5.5 | O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)c(Cl)c1 | nan | |
CHEMBL1585097 | 51809 | 16 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 386 | 3 | 0 | 4 | 5.5 | O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)c(Cl)c1 | nan | |
2016176 | 42463 | 8 | None | 9 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 441 | 7 | 2 | 6 | 4.6 | Nc1c(C(=O)NCCCc2ccccc2)c2nc3ccccc3nc2n1Cc1cccs1 | nan | |
CHEMBL1499346 | 42463 | 8 | None | 9 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 441 | 7 | 2 | 6 | 4.6 | Nc1c(C(=O)NCCCc2ccccc2)c2nc3ccccc3nc2n1Cc1cccs1 | nan | |
7756956 | 39644 | 6 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 353 | 5 | 0 | 5 | 1.8 | Cc1cc(C(=O)CN2C(=O)C(=O)N(C)C2=O)c(C)n1Cc1ccccc1 | nan | |
CHEMBL1474501 | 39644 | 6 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 353 | 5 | 0 | 5 | 1.8 | Cc1cc(C(=O)CN2C(=O)C(=O)N(C)C2=O)c(C)n1Cc1ccccc1 | nan | |
662039 | 20267 | 7 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 417 | 5 | 2 | 7 | 3.5 | CCC(C)NC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
CHEMBL1305537 | 20267 | 7 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 417 | 5 | 2 | 7 | 3.5 | CCC(C)NC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
3800606 | 34920 | 8 | None | 1 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 417 | 5 | 2 | 7 | 3.3 | CC(C)CNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
CHEMBL1432243 | 34920 | 8 | None | 1 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 417 | 5 | 2 | 7 | 3.3 | CC(C)CNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 | nan | |
44422601 | 85581 | 0 | None | -74 | 5 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Activity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 398 | 14 | 4 | 3 | 4.2 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |
CHEMBL228139 | 85581 | 0 | None | -74 | 5 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Activity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 398 | 14 | 4 | 3 | 4.2 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |
2842931 | 46552 | 14 | None | 2 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 328 | 3 | 0 | 4 | 5.4 | Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 | nan | |
CHEMBL1537907 | 46552 | 14 | None | 2 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 328 | 3 | 0 | 4 | 5.4 | Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 | nan | |
2113511 | 31619 | 30 | None | 10 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 324 | 5 | 0 | 4 | 2.5 | Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1 | nan | |
CHEMBL1404553 | 31619 | 30 | None | 10 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 324 | 5 | 0 | 4 | 2.5 | Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1 | nan | |
1472014 | 20633 | 12 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 352 | 3 | 0 | 4 | 4.8 | O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)cc1 | nan | |
CHEMBL1308408 | 20633 | 12 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 352 | 3 | 0 | 4 | 4.8 | O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)cc1 | nan | |
2460650 | 22802 | 13 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 341 | 6 | 0 | 7 | 2.7 | Cc1cc(C(=O)CSc2nnnn2C)c(C)n1Cc1ccccc1 | nan | |
CHEMBL1328093 | 22802 | 13 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ] |
ChEMBL | 341 | 6 | 0 | 7 | 2.7 | Cc1cc(C(=O)CSc2nnnn2C)c(C)n1Cc1ccccc1 | nan | |
5398663 | 45842 | 20 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 285 | 3 | 2 | 5 | 2.0 | O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O | nan | |
CHEMBL1531320 | 45842 | 20 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 285 | 3 | 2 | 5 | 2.0 | O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O | nan | |
2837694 | 45785 | 6 | None | 74 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 420 | 8 | 1 | 5 | 3.2 | CN(C)CCCNS(=O)(=O)c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1 | nan | |
CHEMBL1530797 | 45785 | 6 | None | 74 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ] |
ChEMBL | 420 | 8 | 1 | 5 | 3.2 | CN(C)CCCNS(=O)(=O)c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1 | nan | |
57390239 | 67908 | 0 | None | -25 | 4 | Human | 5.4 | pEC50 | = | 5.4 | Functional | Agonist activity at S1P2 receptorAgonist activity at S1P2 receptor |
ChEMBL | 339 | 3 | 0 | 4 | 3.7 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 |
Showing 1 to 50 of 923 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
10883396 | 3649 | 45 | None | -11 | 4 | Human | 9.2 | pEC50 | = | 9.2 | Binding | Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 9.2 | pEC50 | = | 9.2 | Binding | Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 9.2 | pEC50 | = | 9.2 | Binding | Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 9.2 | pEC50 | = | 9.2 | Binding | Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
49839234 | 117951 | 1 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayAgonist activity at human S1P2 receptor by beta-arrestin recruitment assay |
ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | ||
CHEMBL3403619 | 117951 | 1 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayAgonist activity at human S1P2 receptor by beta-arrestin recruitment assay |
ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | ||
44398076 | 12900 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
CHEMBL1188968 | 12900 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
CHEMBL537849 | 12900 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 8.7 | pEC50 | = | 8.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 8.7 | pEC50 | = | 8.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 8.7 | pEC50 | = | 8.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 8.7 | pEC50 | = | 8.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
44392705 | 66666 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
9821227 | 66666 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL185389 | 66666 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL332472 | 66666 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
44342244 | 64876 | 3 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL182164 | 64876 | 3 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL423691 | 64876 | 3 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
44342246 | 11412 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 396 | 18 | 4 | 5 | 3.2 | CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL115505 | 11412 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 396 | 18 | 4 | 5 | 3.2 | CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL1180159 | 11412 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 396 | 18 | 4 | 5 | 3.2 | CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
44342221 | 12093 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL1183918 | 12093 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
CHEMBL324358 | 12093 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 9.6 | pIC50 | = | 9.6 | Binding | Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.02.106 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 9.6 | pIC50 | = | 9.6 | Binding | Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.02.106 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 9.6 | pIC50 | = | 9.6 | Binding | Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.02.106 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 9.6 | pIC50 | = | 9.6 | Binding | Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.02.106 | ||
10883396 | 3649 | 45 | None | -11 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | ||
5283560 | 3649 | 45 | None | -11 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | ||
911 | 3649 | 45 | None | -11 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | ||
CHEMBL225155 | 3649 | 45 | None | -11 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | ||
11725751 | 12847 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand |
ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.04.069 | ||
11725751 | 12847 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand |
ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.04.070 | ||
CHEMBL118860 | 12847 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand |
ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.04.069 | ||
CHEMBL118860 | 12847 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand |
ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.04.070 |
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