Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
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 DOI
138107701 187464 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
5311181 187464 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
CHEMBL494 187464 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
138107701 187464 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 187464 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 187464 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
138 3081 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3081 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3081 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3081 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3081 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
2720 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
5820 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
6918140 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
CHEMBL1237119 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
DB00374 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
118727298 117413 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 117413 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
118727308 117423 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 117423 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235755 153708 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153708 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727301 117416 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 117416 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839344 152051 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
CHEMBL3967284 152051 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
137636847 155992 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL4061744 155992 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
118727293 117408 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 117408 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727305 117420 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398226 117420 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
127052613 140206 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3804978 140206 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727312 117427 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 117427 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727307 117422 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 117422 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727297 117412 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 117412 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727296 117411 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 117411 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234782 147272 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 147272 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727294 117409 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 117409 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
118727306 117421 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 117421 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 117410 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 117410 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235522 142520 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 142520 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 117417 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 117417 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 117424 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 117424 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727296 117411 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 117411 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44236221 147719 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147719 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
44235044 147585 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3930990 147585 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232565 153972 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153972 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235044 142863 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142863 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727311 117426 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 117426 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
126495507 139379 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793167 139379 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727292 117407 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398213 117407 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727313 117428 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 117428 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
44235519 148205 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 148205 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232564 145429 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 145429 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727288 117403 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 117403 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44235291 151931 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151931 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44233041 145275 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
CHEMBL3912947 145275 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
138107701 187464 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 187464 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 187464 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44219292 112582 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3301604 112582 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44235522 142520 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3890685 142520 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
44234781 142536 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3890828 142536 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233522 142828 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
CHEMBL3893059 142828 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
44235044 142863 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3893346 142863 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234027 142929 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3893909 142929 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44235289 143059 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3895137 143059 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232806 143172 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3896069 143172 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
58172125 143244 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3896580 143244 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
44234528 143571 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3899229 143571 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234532 143669 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3900038 143669 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233772 143674 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3900091 143674 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234533 143996 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3902808 143996 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44233523 144010 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
CHEMBL3902855 144010 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
44235040 144594 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3907754 144594 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235291 145145 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3912086 145145 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44232564 145429 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3914174 145429 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
44236219 145441 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
CHEMBL3914231 145441 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
44234780 145471 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3914443 145471 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44233776 145475 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3914495 145475 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233282 145584 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3915367 145584 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
44236220 145806 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3917017 145806 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
58172129 145842 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3917222 145842 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233775 145846 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
CHEMBL3917276 145846 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
44234028 145872 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
CHEMBL3917503 145872 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
44236217 145968 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3918258 145968 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44219292 146088 38 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3919269 146088 38 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44234029 146219 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3920236 146219 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44232567 146332 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3921158 146332 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44235983 146378 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3921534 146378 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234032 146438 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3922000 146438 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44233042 146535 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3922686 146535 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44235289 146669 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3923745 146669 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233520 146830 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
CHEMBL3924965 146830 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
58172126 146897 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
CHEMBL3925563 146897 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
44235521 146956 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3926078 146956 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
58172128 147001 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
CHEMBL3926491 147001 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
44233280 147015 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3926604 147015 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
44235984 147264 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
CHEMBL3928658 147264 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
44234782 147272 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3928729 147272 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235044 147585 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3930990 147585 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234284 147694 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
CHEMBL3931899 147694 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
44235290 147855 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
CHEMBL3933131 147855 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
44234032 147925 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3933704 147925 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44232808 148003 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3934336 148003 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44234026 148038 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3934619 148038 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44235519 148205 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3935924 148205 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
58172127 148212 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
CHEMBL3935961 148212 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
44233038 148340 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3937089 148340 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44233283 148504 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
CHEMBL3938313 148504 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
44233777 148548 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3938716 148548 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232804 148691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
CHEMBL3939932 148691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
44233518 148828 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
CHEMBL3941036 148828 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
44235519 149038 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3942683 149038 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235043 149077 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
CHEMBL3943011 149077 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
44234530 149105 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
CHEMBL3943161 149105 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
44232568 149192 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3943791 149192 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
44234529 149425 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3945849 149425 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44234532 150225 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3952237 150225 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233774 150236 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3952293 150236 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233521 150254 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
CHEMBL3952439 150254 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
44235042 150271 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
CHEMBL3952569 150271 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
44232569 150408 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3953739 150408 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
44233279 150669 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
CHEMBL3955699 150669 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
44233039 150896 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3957516 150896 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44232805 150929 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3957760 150929 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
44235979 151085 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3959044 151085 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44233040 151247 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
CHEMBL3960203 151247 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
44233281 151369 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
CHEMBL3961361 151369 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
44235756 151418 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3961761 151418 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44233773 151426 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
CHEMBL3961809 151426 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
44235041 151759 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3964788 151759 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235291 151931 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3966307 151931 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44235039 151937 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
CHEMBL3966331 151937 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
44236216 152154 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3968156 152154 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44234783 152229 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
CHEMBL3968835 152229 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
44235982 152264 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3969137 152264 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44232566 152443 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
CHEMBL3970829 152443 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
44235520 152958 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3975122 152958 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44234528 152985 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3975263 152985 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234283 152993 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
CHEMBL3975307 152993 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
44232807 153103 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
CHEMBL3976286 153103 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
44233519 153237 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
CHEMBL3977415 153237 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
44236218 153254 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3977559 153254 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
44234779 153279 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
CHEMBL3977761 153279 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
44235980 153424 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
CHEMBL3979096 153424 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
44233043 153614 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
CHEMBL3980758 153614 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
44234782 153689 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3981383 153689 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235981 153705 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3981484 153705 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44235755 153708 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3981509 153708 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
44232803 153794 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
CHEMBL3982288 153794 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
44233278 153905 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
CHEMBL3983200 153905 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
44232565 153972 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3983767 153972 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
44235754 153998 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3984010 153998 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44234278 154020 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3984207 154020 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
44235753 154179 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
CHEMBL3985726 154179 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
118727297 117412 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 117412 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727311 117426 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 117426 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 117430 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 117430 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3578 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3578 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3578 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3578 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3578 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44234532 150225 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 150225 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727285 117400 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 117400 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
5852 2617 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2617 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2617 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44232568 149192 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 149192 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727293 117408 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 117408 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 117410 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 117410 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
58172125 143244 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3896580 143244 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44304181 203273 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 203273 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
127052614 140226 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805176 140226 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727310 117425 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 117425 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727301 117416 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 117416 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727304 117419 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 117419 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5283086 203310 24 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
CHEMBL64804 203310 24 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
118727314 117429 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 117429 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727286 117401 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398207 117401 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235291 151931 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151931 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44232568 149192 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 149192 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727299 117414 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 117414 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 147925 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147925 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
56839536 143169 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
CHEMBL3896035 143169 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
44235044 142863 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142863 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44235521 146956 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146956 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235519 148205 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 148205 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727287 117402 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 117402 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232564 145429 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 145429 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727314 117429 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 117429 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
1883 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
1916 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
5280360 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
913 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
CHEMBL548 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
DB00917 3082 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
118727291 117406 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 117406 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
118727290 117405 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 117405 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234532 150225 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 150225 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727291 117406 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 117406 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44303980 168074 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL432522 168074 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
118727288 117403 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 117403 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 117424 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 117424 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727307 117422 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 117422 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44235522 142520 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 142520 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727289 117404 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 117404 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 117427 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 117427 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727308 117423 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 117423 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235521 146956 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146956 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44233521 150254 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952439 150254 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727303 117418 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 117418 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727306 117421 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 117421 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44219292 146088 38 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 146088 38 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
69753740 140222 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
CHEMBL3805134 140222 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
44234782 147272 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 147272 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
44234532 143669 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143669 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118352160 139429 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793892 139429 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44236221 147719 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3932106 147719 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44236221 147719 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147719 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
118727298 117413 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 117413 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
44219292 112582 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112582 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
118352285 139469 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3794226 139469 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44235520 152958 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152958 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234532 143669 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143669 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
56649302 152666 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3972583 152666 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
44235520 147273 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3928737 147273 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44219292 146088 38 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 146088 38 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 146438 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 146438 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727315 117430 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 117430 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3578 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3578 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3578 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3578 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3578 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44235520 152958 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152958 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727287 117402 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 117402 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727290 117405 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 117405 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727303 117418 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 117418 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44234531 151417 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3961754 151417 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
118727300 117415 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 117415 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 146438 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 146438 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727300 117415 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 117415 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44235755 153708 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153708 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 117417 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 117417 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232565 153972 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153972 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727316 117431 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 117431 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
118727310 117425 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 117425 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029402 139358 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793009 139358 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727294 117409 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 117409 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44219292 112582 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112582 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 147925 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147925 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727313 117428 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 117428 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
118727304 117419 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 117419 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839342 149007 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3942394 149007 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
118727299 117414 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 117414 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
118727289 117404 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 117404 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234028 145872 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145872 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
56839343 144279 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
CHEMBL3904989 144279 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
118727285 117400 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 117400 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
24901445 87246 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 87246 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416266 14700 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206115 14700 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL212943 14700 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44416264 14856 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207438 14856 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL405770 14856 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10028418 14672 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14672 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14672 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901438 86701 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86701 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10694649 13567 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
CHEMBL119397 13567 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
10671942 104216 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
CHEMBL309835 104216 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
16664733 154827 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154827 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
24901440 86989 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86989 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901439 86786 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86786 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901443 87203 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 87203 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10717385 168512 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
CHEMBL435382 168512 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
24901449 153598 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153598 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901451 154435 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 154435 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
10529683 163644 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
CHEMBL420404 163644 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
24901441 146097 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 146097 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86686 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86686 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
44416281 14701 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206120 14701 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL215442 14701 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10553794 163638 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
CHEMBL420398 163638 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
24901447 87299 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 87299 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12833 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12833 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12833 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10623568 205328 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
CHEMBL79511 205328 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
24901442 87040 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 87040 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416279 14818 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207258 14818 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL379203 14818 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9825740 14673 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205678 14673 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132649 14673 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
44416294 14884 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207781 14884 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL438092 14884 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10601359 104299 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
CHEMBL309987 104299 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
10028418 14672 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14672 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14672 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901437 88060 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 88060 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12833 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12833 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12833 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901446 154828 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154828 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10813802 13789 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
CHEMBL119550 13789 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
24901448 86942 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86942 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901444 87204 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 87204 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
10502610 163718 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
CHEMBL420507 163718 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
19358473 14823 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207287 14823 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL386580 14823 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44377464 120085 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
CHEMBL350832 120085 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
10402929 57543 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
CHEMBL166351 57543 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
10204312 3348 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3348 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
1969 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1969 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
9839644 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
CHEMBL9540 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 811 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
138 3081 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3081 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3081 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3081 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3081 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138107701 187464 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 187464 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 187464 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3854 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
5820 3854 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
6918140 3854 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
CHEMBL1237119 3854 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
DB00374 3854 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
138107701 187464 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 187464 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 187464 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
2720 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
5820 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
6918140 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
CHEMBL1237119 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
DB00374 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3854 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
11743147 587 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
5851 587 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
1883 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3082 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
69658829 217697 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
5853 1568 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
73755162 1568 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
127861 694 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1963 694 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
CHEMBL125569 694 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1962 305 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
5311226 305 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
1968 3754 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
5311243 3754 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
CHEMBL2104890 3754 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
1965 3774 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
73755022 3774 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
1987175 3794 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
9283 3794 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
CHEMBL1372836 3794 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
10204312 3348 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
10204312 3348 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040
4042 3348 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
4042 3348 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
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 Reference
ligand		 Fold
selectivity		 # Tested
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 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

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 DOI
9955130 9505 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11211 9505 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
138107701 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
5311181 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
CHEMBL494 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
138107701 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
5311181 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
CHEMBL494 187464 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
127029421 139320 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3792615 139320 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
86277844 111926 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
CHEMBL3287898 111926 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
44235520 152958 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152958 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
24901449 153598 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153598 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901439 86786 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86786 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86686 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86686 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
155544367 173374 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
CHEMBL4527708 173374 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
58602756 139431 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793903 139431 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
138107701 187464 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
5311181 187464 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
CHEMBL494 187464 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
127029417 139435 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 139435 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
138 3081 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
1882 3081 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
5280723 3081 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
CHEMBL495 3081 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
DB00770 3081 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
44235522 142520 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 142520 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
11296282 1409 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
5822 1409 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
CHEMBL565591 1409 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
9847589 97210 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268477 97210 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
10095633 162231 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL416334 162231 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
131814 12393 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL118567 12393 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
10090048 169416 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL442405 169416 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
44219292 146088 38 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 146088 38 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 187464 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 187464 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 187464 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
44234032 147925 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147925 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
15236833 11019 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11746 11019 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
44157014 192617 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521609 192617 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
44235755 153708 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153708 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727303 117418 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 117418 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
23355418 6701 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL10836 6701 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44267380 9980 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11480 9980 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
127028521 139472 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3794245 139472 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
9823958 9672 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11291 9672 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
44267033 6544 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10829 6544 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235044 142863 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142863 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727306 117421 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 117421 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44267032 97162 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268051 97162 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44267058 163219 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL418338 163219 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235521 146956 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146956 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44234782 147272 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 147272 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727311 117426 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 117426 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029147 139510 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3793541 139510 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3794662 139510 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
44266708 4782 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
CHEMBL10404 4782 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
44267244 162703 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL417069 162703 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44234532 150225 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 150225 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
1892 747 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 747 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 747 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
1883 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
1916 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
5280360 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
913 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
CHEMBL548 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
DB00917 3082 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
138107701 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
5311181 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
CHEMBL494 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
138107701 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5311181 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
CHEMBL494 187464 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5852 2617 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2617 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2617 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727316 117431 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 117431 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
44232565 153972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153972 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
10477568 4878 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10442 4878 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10477567 7196 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10856 7196 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
127028838 139489 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3794451 139489 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
127029416 139421 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793824 139421 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
118727301 117416 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 117416 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 117427 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 117427 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
44159772 68392 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916708 68392 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
24901441 146097 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 146097 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901451 154435 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 154435 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
24901448 86942 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86942 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10090958 10649 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
CHEMBL117038 10649 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
5311035 97803 29 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
CHEMBL271896 97803 29 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
44219292 112582 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112582 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
15290482 9282 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL11088 9282 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235519 148205 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 148205 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
15428700 4582 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
CHEMBL10261 4582 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
9955518 11043 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
CHEMBL11765 11043 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
44565193 176860 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL461390 176860 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44267245 10134 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11571 10134 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901444 87204 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 87204 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44236221 147719 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147719 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
127029420 139373 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793117 139373 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
127028839 139387 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793265 139387 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
44267196 97008 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL266622 97008 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901447 87299 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 87299 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
16664733 154827 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154827 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44266736 5117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10564 5117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
24901446 154828 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154828 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901442 87040 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 87040 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
15290515 7132 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10853 7132 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
44266758 98410 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL275493 98410 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
44234532 143669 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143669 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
44235291 151931 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151931 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
24901437 88060 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 88060 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44159530 68384 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916700 68384 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
11462174 3820 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
9277 3820 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
CHEMBL560993 3820 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
DB11900 3820 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
44627395 196872 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
CHEMBL565992 196872 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
44266768 4932 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10470 4932 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44266768 4932 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
CHEMBL10470 4932 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
5077 3578 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3578 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3578 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3578 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3578 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727314 117429 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 117429 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 117430 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 117430 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44190762 176880 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 176880 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
118727308 117423 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 117423 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
5077 3578 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
7552 3578 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
9913767 3578 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
CHEMBL238804 3578 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
DB11362 3578 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
10320441 5448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
CHEMBL10742 5448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
10320441 5448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10742 5448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10452166 18969 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL128747 18969 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
24901440 86989 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86989 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901438 86701 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86701 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
127028837 139392 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793336 139392 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
24901445 87246 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 87246 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901436 88012 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234391 88012 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44266710 5445 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
CHEMBL10740 5445 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
10321522 167631 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
CHEMBL430154 167631 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
138107701 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
15290495 98237 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL274393 98237 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
9934864 207546 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
CHEMBL94751 207546 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
9934864 207546 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
CHEMBL94751 207546 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
118727307 117422 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 117422 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44627515 196837 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
CHEMBL565799 196837 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
138107701 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 187464 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
127029418 139394 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793345 139394 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
24901443 87203 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 87203 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44234032 146438 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 146438 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44266775 4875 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
CHEMBL10439 4875 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
138107701 187464 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 187464 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 187464 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
11414893 207057 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9172 207057 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11230941 208343 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9936 208343 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10185382 64415 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813119 64415 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
1932 2942 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
5311228 2942 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
CHEMBL3286796 2942 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
9807448 203172 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
CHEMBL64246 203172 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
11771014 207356 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9367 207356 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56681885 64419 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813122 64419 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
44402824 71121 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
CHEMBL195456 71121 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
10277744 64412 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813116 64412 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10185103 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL1206056 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL190497 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
10185103 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL1206056 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL190497 14693 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
11461588 4269 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10058 4269 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11402676 208374 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9953 208374 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
10299717 64417 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813120 64417 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
10300724 64429 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813275 64429 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
9939791 161918 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
CHEMBL415310 161918 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
44402710 71959 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
CHEMBL197319 71959 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
44304334 201576 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL60555 201576 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
56682059 64821 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819619 64821 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
11269563 141610 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
CHEMBL385126 141610 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
138 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
1882 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
5280723 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
CHEMBL495 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
DB00770 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
138 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
138 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
1882 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
5280723 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
CHEMBL495 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
DB00770 3081 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
56678560 64433 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813279 64433 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
11488860 19291 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
CHEMBL1290413 19291 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
11198334 207731 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9573 207731 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11737656 208245 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9873 208245 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56668353 64432 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813278 64432 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56665068 64824 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819622 64824 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56665068 64824 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819622 64824 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
44400189 67489 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL189378 67489 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
57391066 68242 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915864 68242 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
56675399 64816 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819614 64816 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
11260449 68230 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915677 68230 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11237257 67607 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
CHEMBL190288 67607 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
10116116 64411 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813115 64411 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
53358922 64430 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813276 64430 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
15947857 155513 7 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
CHEMBL404199 155513 7 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
10163305 64422 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813125 64422 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
11374965 69193 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL192662 69193 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
56671851 64437 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813283 64437 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9809136 106889 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL314533 106889 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
9895436 107016 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL315391 107016 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
53358921 64441 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813287 64441 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56678561 64434 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813280 64434 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
21877027 208313 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9910 208313 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10139183 68222 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915669 68222 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11220357 97345 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL269403 97345 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
11186023 207360 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9368 207360 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
53494965 64813 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1819611 64813 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
11236846 68227 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1915674 68227 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
53494965 64813 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
CHEMBL1819611 64813 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
11350967 67187 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187758 67187 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56661652 64810 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819609 64810 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56664921 64438 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813284 64438 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9938626 206833 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL90491 206833 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
56668527 64808 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819607 64808 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
11282605 67973 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL191175 67973 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44219292 112582 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112582 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 187464 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 187464 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 187464 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44304436 203320 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64854 203320 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56661510 64439 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813285 64439 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11336395 207780 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9604 207780 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11255468 207840 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9639 207840 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44266308 208027 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9744 208027 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460304 208446 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9998 208446 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
22024188 97361 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
CHEMBL269520 97361 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
11254374 207747 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9583 207747 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
10228100 64414 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813118 64414 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
56661509 64431 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813277 64431 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
57391065 68239 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915861 68239 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
57403305 68240 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915862 68240 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11260506 67540 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL189694 67540 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11352417 68229 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915676 68229 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
56672019 64814 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819612 64814 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
56675398 64809 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
CHEMBL1819608 64809 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
56675398 64809 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819608 64809 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
10116114 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL364841 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10116114 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
CHEMBL364841 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
10116114 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
CHEMBL364841 125886 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
11278428 207695 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9552 207695 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11208785 207416 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9398 207416 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
11461526 207705 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9558 207705 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460765 98359 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275233 98359 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
11324024 207493 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9442 207493 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
138107701 187464 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 187464 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 187464 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
127046072 139836 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3798917 139836 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3799044 139836 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
11597294 166176 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
CHEMBL426387 166176 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
44234028 145872 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145872 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
11201693 67385 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188758 67385 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10225921 14814 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1207206 14814 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL363350 14814 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
11316066 67310 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188384 67310 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10300616 64426 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813272 64426 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56658143 64805 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819604 64805 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
11292620 69192 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL192661 69192 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10185612 64413 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813117 64413 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11392403 4550 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10241 4550 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11739220 206658 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL8935 206658 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11336790 208202 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9846 208202 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11403716 4242 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10044 4242 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244046 4246 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10045 4246 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460734 208450 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9999 208450 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44234032 147925 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147925 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44304058 203177 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64254 203177 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
21893828 64442 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813288 64442 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56681899 64443 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813289 64443 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
57401554 68244 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915866 68244 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11294449 68226 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915673 68226 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
9874010 207190 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL92539 207190 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
11261579 67599 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190236 67599 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
10028418 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL1205677 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL132589 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
10028418 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL1205677 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL132589 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
10028418 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL1205677 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL132589 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
10028418 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1205677 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL132589 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
10028418 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL1205677 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL132589 14672 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11293771 67669 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL190735 67669 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56664920 64436 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813282 64436 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11201307 67890 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL191056 67890 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11750835 67449 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL189063 67449 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
11454655 67774 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190840 67774 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11519006 102486 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL2373410 102486 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL3040272 102486 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
138107701 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
5311181 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
CHEMBL494 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
138107701 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
5311181 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
CHEMBL494 187464 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
10028418 14672 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14672 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14672 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9955802 69184 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL192613 69184 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11404217 98118 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL273530 98118 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11473193 98348 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275124 98348 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11381211 207742 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9580 207742 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
11370857 207861 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9648 207861 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11267409 207864 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9649 207864 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
11174065 208239 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9868 208239 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11224239 64804 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819603 64804 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11224239 64804 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819603 64804 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
3356 2280 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
4326 2280 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
9867642 2280 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
CHEMBL426559 2280 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
DB11629 2280 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
11166017 67139 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187544 67139 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44234032 147925 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147925 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
138107701 187464 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 187464 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 187464 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
11743212 17164 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
CHEMBL125588 17164 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
10227894 64420 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813123 64420 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
10181606 206351 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
CHEMBL87371 206351 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
44304388 203152 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL64187 203152 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
11282319 67664 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
CHEMBL190708 67664 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
44219292 112582 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112582 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
10139047 12833 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12833 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12833 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
11318288 67951 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
CHEMBL191118 67951 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
11186079 4210 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10024 4210 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11175906 207368 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9371 207368 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11243628 208261 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9883 208261 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11391560 167743 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL430286 167743 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244380 207812 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9626 207812 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
5855 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
9911469 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
CHEMBL196779 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
11407826 123646 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL361939 123646 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44326793 14654 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL1205415 14654 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL94694 14654 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
13231966 100951 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL294108 100951 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
1892 747 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 747 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 747 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
44304181 203273 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 203273 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
13231966 100951 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL294108 100951 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56675229 64421 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813124 64421 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
10278907 64418 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813121 64418 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
44304474 202931 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL62868 202931 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
56681898 64435 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813281 64435 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56678559 64428 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813274 64428 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
9934864 207546 12 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
CHEMBL94751 207546 12 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
10117702 64427 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813273 64427 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
127029417 139435 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 139435 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
10501053 1587 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
8314 1587 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
CHEMBL3137314 1587 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
1968 3754 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
5311243 3754 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
CHEMBL2104890 3754 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
1917 927 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 927 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 927 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 927 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
119461 320 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
1896 320 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
CHEMBL1317823 320 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
119304 752 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 752 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 752 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 752 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1940 1663 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 1663 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 1663 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 1663 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 1663 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1551 2286 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 2286 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 2286 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 2286 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 2286 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1913 2464 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 2464 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1817 2542 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 2542 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 2542 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 2542 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 2542 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1881 3079 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 3079 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 3079 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 3079 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 3079 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1883 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3082 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3082 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3082 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1884 3083 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3083 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3083 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3083 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3083 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3083 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3083 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3083 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3083 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3083 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3083 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3083 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3083 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3083 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3083 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1980 3662 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1985 3662 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
6437074 3662 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1888 3900 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 3900 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 3900 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 3900 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311035 97803 29 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
CHEMBL271896 97803 29 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
1973 203483 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 203483 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 203483 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
134689669 216050 0 3H-ILOPROST -5495 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
91798918 216063 0 3H-ILOPROST -1479 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
67861203 216065 0 3H-ILOPROST -21379 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
132748 216412 0 3H-ILOPROST -7 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 3 2 4 4.6 C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl None
None 216414 0 3H-ILOPROST -10 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 477 11 1 5 5.1 C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 None
None 216456 0 Functional -19 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 216456 0 3H-PGI2 -19 3 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 216460 0 3H-PGI2 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
None 216460 0 3H-PGI2 -1 2 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
89077401 216044 0 3H-ILOPROST -1 12 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
89077401 216044 0 3H-ILOPROST -1 12 Mouse 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 216045 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 216045 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3081 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138 3081 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3081 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3081 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3081 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3081 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3081 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3081 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3081 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3081 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 216046 0 3H-ILOPROST 2 3 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 11 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O None
None 216047 0 3H-ILOPROST 6 2 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 398 8 3 4 3.3 CC#CCC(C)C(C=CC1C(CC2C1C3=C(O2)C(=CC=C3)CCCC(=O)O)O)O None
133126726 216045 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 216045 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 216045 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 216045 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1917 927 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 927 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 927 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 927 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
None 216413 0 3H-ILOPROST -7079 6 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 384 9 3 3 4.3 C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O None
133126726 216045 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 216045 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3081 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3081 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3081 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3081 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3081 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 216048 0 3H-ILOPROST 15 2 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 442 9 1 5 5.1 CC1=C(C2=C(CC1)C(=CC=C2)OCC(=O)O)CCON=C(C3=CC=CC=C3)C4=CN=CC=C4 None
3356 2280 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
4326 2280 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
9867642 2280 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
CHEMBL426559 2280 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
DB11629 2280 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
5077 3578 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3578 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3578 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3578 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3578 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
138 3081 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3081 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3081 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3081 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3081 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5077 3578 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3578 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3578 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3578 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3578 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
69658829 217697 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
1917 927 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 927 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 927 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 927 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
133126726 216045 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 216045 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
69658829 217697 0 None -1 4 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
None 216459 0 3H-PGI2 1 2 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
None 216459 0 3H-PGI2 -1 2 Mouse 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
1917 927 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 927 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 927 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 927 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
138107701 187464 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 187464 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 187464 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5077 3578 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3578 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3578 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3578 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3578 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5077 3578 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3578 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3578 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3578 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3578 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
138 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
138 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
1882 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
1882 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5280723 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
5280723 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
CHEMBL495 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
CHEMBL495 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
DB00770 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
DB00770 3081 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5852 2617 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2617 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2617 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
10204312 3348 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3348 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
10141039 1687 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
5854 1687 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
1967 601 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 601 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
2720 3854 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3854 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3854 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3854 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3854 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5852 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5852 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
9931891 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
CHEMBL239226 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2617 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
1967 601 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 601 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
1895 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
1895 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
6435378 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
6435378 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
CHEMBL236025 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
CHEMBL236025 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
DB01088 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
DB01088 2007 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
1967 601 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
5282428 601 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
1917 927 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
5311044 927 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
631 927 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
CHEMBL160629 927 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
1034 3085 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
1915 3085 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5282411 3085 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
CHEMBL1139 3085 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
DB01240 3085 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5855 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
9911469 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
CHEMBL196779 1645 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
1969 811 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 811 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 811 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1888 3900 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1974 3900 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
5311493 3900 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
CHEMBL521784 3900 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1892 747 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
25886893 747 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
CHEMBL1628262 747 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
1893 795 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
5311242 795 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
CHEMBL148319 795 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
1893 795 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
5311242 795 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
CHEMBL148319 795 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
1964 2929 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
6536812 2929 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
CHEMBL188539 2929 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
138 3081 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1882 3081 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
5280723 3081 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
CHEMBL495 3081 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
DB00770 3081 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1934 2090 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
5311244 2090 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
CHEMBL4522827 2090 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
1917 927 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
5311044 927 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
631 927 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
CHEMBL160629 927 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
1895 2007 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
6435378 2007 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
CHEMBL236025 2007 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
DB01088 2007 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928