ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155146067	184607	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184607	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155154170	184748	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155146047	186597	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186597	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	3238641	31405	37	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1402510	31405	37	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	2566134	69113	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL1923999	69113	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	584653	184418	44	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	CHEMBL4846114	184418	44	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	155153910	184423	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	CHEMBL4846170	184423	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	155145976	184456	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4846676	184456	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	155154008	184474	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4846959	184474	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154202	184489	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4847181	184489	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153982	184499	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	CHEMBL4847374	184499	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	7015981	184557	31	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	CHEMBL4848369	184557	31	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	155154180	184583	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4848664	184583	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	114322379	184592	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4848825	184592	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155153838	184620	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	CHEMBL4849270	184620	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	155153758	184646	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	CHEMBL4849588	184646	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	155153970	184676	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	CHEMBL4849913	184676	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	155154172	184729	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4850633	184729	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	155154044	184804	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4851715	184804	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155145940	185014	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4854872	185014	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	84614649	185034	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	CHEMBL4855127	185034	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	155153740	185053	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4855384	185053	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	107881084	185066	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	CHEMBL4855567	185066	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	155154045	185102	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856071	185102	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146040	185124	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4856356	185124	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145911	185157	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4857097	185157	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	102723930	185158	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	CHEMBL4857110	185158	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	155154009	185159	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4857124	185159	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155153960	185206	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	CHEMBL4857656	185206	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	155153995	185277	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	CHEMBL4858920	185277	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	155153774	185285	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4859063	185285	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155154005	185291	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	CHEMBL4859171	185291	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	155146005	185293	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4859266	185293	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903220	185318	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	CHEMBL4859510	185318	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	155153791	185338	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	CHEMBL4859833	185338	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	155154252	185339	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4859840	185339	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155154021	185351	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4860115	185351	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154007	185468	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861940	185468	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	22682941	185501	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	CHEMBL4862434	185501	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	155153807	185556	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	CHEMBL4863225	185556	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	155153800	185598	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	CHEMBL4863762	185598	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	43531176	185618	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4864076	185618	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	137553505	185627	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4864265	185627	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155154133	185674	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	CHEMBL4865044	185674	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	7022231	185738	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866106	185738	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	113925944	185745	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	CHEMBL4866201	185745	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	155153793	185748	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	CHEMBL4866223	185748	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	29080666	185764	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	CHEMBL4866428	185764	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	155154248	185780	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4866577	185780	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155153775	185794	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	CHEMBL4866840	185794	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	155145950	185843	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4867568	185843	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155153837	185845	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	CHEMBL4867604	185845	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	155146125	185851	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4867684	185851	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	43092667	185854	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4867744	185854	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155154000	185870	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4868055	185870	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	155154006	185882	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4868255	185882	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153812	185924	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	CHEMBL4869118	185924	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	155153736	185939	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	CHEMBL4869336	185939	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	155154048	185940	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869352	185940	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153773	185969	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	CHEMBL4869694	185969	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	155154141	186038	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	CHEMBL4870727	186038	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	155154020	186054	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4870998	186054	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154205	186080	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871418	186080	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154075	186127	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871892	186127	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153810	186135	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4872055	186135	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153994	186152	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	CHEMBL4872342	186152	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	155154215	186179	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4872646	186179	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154082	186185	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	CHEMBL4872725	186185	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	890775	186210	35	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873123	186210	35	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584777	186230	46	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	CHEMBL4873423	186230	46	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	155154016	186255	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4873773	186255	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153999	186269	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873923	186269	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155146134	186270	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4873967	186270	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	155146091	186317	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4874662	186317	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153987	186357	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875200	186357	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	156048221	186361	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4875343	186361	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154219	186364	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875377	186364	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	832097	186454	30	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	CHEMBL4876586	186454	30	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	155153971	186468	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	CHEMBL4876749	186468	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	155145974	186482	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4876954	186482	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	7015989	186483	32	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4877006	186483	32	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	155154019	186495	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877244	186495	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154178	186496	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877261	186496	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145948	186574	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878337	186574	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153809	186582	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4878428	186582	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153794	186612	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	CHEMBL4879041	186612	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	929494	39003	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	CHEMBL1468323	39003	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	725872	42595	40	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	CHEMBL1500515	42595	40	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	891145	52050	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1587117	52050	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155146121	184435	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4846341	184435	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	17605178	184538	21	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	CHEMBL4847901	184538	21	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	7015983	184571	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	CHEMBL4848511	184571	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	155154010	184577	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	CHEMBL4848586	184577	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	155146163	184793	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4851598	184793	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	28542041	184796	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	CHEMBL4851647	184796	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	155154015	184820	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	CHEMBL4851939	184820	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	155154056	184822	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4851949	184822	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	155154148	184829	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	CHEMBL4852032	184829	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	22682321	184893	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4852959	184893	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	11472211	185044	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	CHEMBL4855304	185044	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	15487504	185068	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4855628	185068	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	116688442	185116	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	CHEMBL4856288	185116	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	155154083	185168	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4857218	185168	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155153972	185234	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	CHEMBL4858105	185234	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	155146161	185270	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4858773	185270	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	65339188	185284	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4859048	185284	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	13013688	185306	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4859370	185306	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	155146132	185345	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	CHEMBL4860022	185345	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	155153997	185454	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4861721	185454	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	63531317	185471	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4861974	185471	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	24225858	185476	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	CHEMBL4862041	185476	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	155153755	185492	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4862314	185492	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	155153805	185552	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4863173	185552	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	155154003	185562	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863275	185562	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	155154024	185600	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	CHEMBL4863823	185600	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	17605176	185602	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863854	185602	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584738	185624	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	CHEMBL4864171	185624	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	155154171	185641	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	CHEMBL4864441	185641	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	20991272	185795	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866841	185795	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	20985043	185799	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	CHEMBL4866888	185799	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	721137	185807	50	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	CHEMBL4866984	185807	50	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	155153808	185866	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	CHEMBL4868006	185866	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	82096332	185913	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4868865	185913	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	155153803	185968	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869674	185968	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153783	186016	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4870496	186016	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155154195	186020	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4870512	186020	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	8977162	186088	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	CHEMBL4871542	186088	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	155153984	186102	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4871699	186102	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	3288323	186112	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4871766	186112	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155153862	186167	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4872542	186167	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155146072	186190	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4872766	186190	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	155153991	186262	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4873848	186262	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	14974397	186280	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4874104	186280	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	155154050	186291	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4874272	186291	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	81781305	186402	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4875899	186402	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	155146174	186434	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4876298	186434	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154076	186489	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	CHEMBL4877160	186489	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	155153754	186583	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	CHEMBL4878462	186583	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	155154070	186620	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4879226	186620	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	155154170	184748	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155145968	185025	5	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154002	184868	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184868	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	186108	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153792	185825	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	4366362	184685	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	4366362	184685	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	185025	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146009	186353	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	186353	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	186380	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	186380	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145968	185025	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146136	186538	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155146147	186380	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	186380	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153902	185307	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	185307	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145946	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153934	186053	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	CHEMBL4870947	186053	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	155154002	184868	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184868	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	186108	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	186244	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	186244	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	155153792	185825	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153902	185307	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	185307	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	186353	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	186353	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	186380	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	186380	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153792	185825	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155145946	185271	6	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	186108	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146136	186538	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145968	185025	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146147	186380	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	186380	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155154002	184868	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184868	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146067	184607	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184607	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155145900	186108	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145968	185025	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	106903214	186244	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	186244	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184685	37	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	185139	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	185139	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185825	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153792	185825	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155146136	186538	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	185139	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	185139	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153902	185307	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	185307	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	107119671	184851	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184851	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155146067	184607	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184607	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146136	186538	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	185271	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	186108	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	186353	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	186353	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146047	186597	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186597	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155146009	186353	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	186353	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146136	186538	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155146136	186538	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	186538	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	185139	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	185139	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146147	186380	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	186380	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	4366362	184685	37	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	185139	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	185139	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146009	186353	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	186353	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155153902	185307	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	185307	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153902	185307	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	185307	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	186244	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	186244	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184685	37	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155153780	186305	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	186305	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154170	184748	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154170	184748	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	890753	31618	39	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	CHEMBL1404550	31618	39	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	155146086	184496	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	CHEMBL4847344	184496	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	155146130	184511	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	CHEMBL4847516	184511	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	155154149	184514	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4847582	184514	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155153911	184662	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	CHEMBL4849736	184662	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	155146026	184732	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4850676	184732	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	155154004	184734	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	CHEMBL4850688	184734	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	19619635	184791	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4851582	184791	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	91105735	184794	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	CHEMBL4851614	184794	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	903815	184799	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL4851668	184799	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	155153785	184800	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4851669	184800	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	155154017	184898	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4852989	184898	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	4442182	184900	41	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	CHEMBL4853044	184900	41	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	103238459	184934	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	CHEMBL4853544	184934	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	155154052	184954	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4853811	184954	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146123	185061	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4855464	185061	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155784453	185106	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856138	185106	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146049	185108	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856167	185108	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154204	185118	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856296	185118	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154013	185152	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	CHEMBL4857004	185152	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	155153735	185261	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	CHEMBL4858571	185261	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	155153998	185325	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	CHEMBL4859587	185325	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	155153813	185421	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861329	185421	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154400	185426	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861423	185426	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154049	185430	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4861439	185430	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154027	185433	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	CHEMBL4861452	185433	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	155146107	185472	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4861980	185472	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154040	185591	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	CHEMBL4863644	185591	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	155153798	185644	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4864507	185644	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154046	185649	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4864569	185649	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903207	185651	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	CHEMBL4864640	185651	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	155153702	185746	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	CHEMBL4866218	185746	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	62669913	185778	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4866560	185778	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155153739	185838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4867549	185838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153757	185875	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4868173	185875	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	19620501	185893	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4868548	185893	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	155701700	185912	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	CHEMBL4868856	185912	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	155153801	185920	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	CHEMBL4869062	185920	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	155153802	186119	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	CHEMBL4871829	186119	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	155154216	186129	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871932	186129	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154203	186166	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	CHEMBL4872532	186166	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	155154200	186192	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	CHEMBL4872809	186192	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	155146160	186288	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	CHEMBL4874203	186288	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	155146102	186318	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	CHEMBL4874670	186318	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	29789593	186324	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4874777	186324	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	20984378	186458	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	CHEMBL4876625	186458	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	155154217	186484	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	CHEMBL4877028	186484	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	155154152	186501	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	CHEMBL4877399	186501	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	155153804	186550	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	CHEMBL4878001	186550	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	107119671	184851	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184851	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	4366362	184685	37	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184685	37	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	185025	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	185025	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146047	186597	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186597	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153780	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146067	184607	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184607	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146067	184607	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184607	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155153780	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154251	185139	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	185139	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185825	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185825	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153780	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	186305	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186597	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186597	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	185271	6	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	185271	6	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155154170	184748	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184868	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184868	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153780	186305	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	186305	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186597	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186597	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	106903214	186244	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	186244	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	107119671	184851	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184851	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155145900	186108	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	186108	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154170	184748	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184748	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184868	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184868	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)