ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155146067	191386	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	191386	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155154170	191527	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155146047	193376	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	193376	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	3238641	38179	37	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1402510	38179	37	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	2566134	75888	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL1923999	75888	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	584653	191197	44	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	CHEMBL4846114	191197	44	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	155153910	191202	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	CHEMBL4846170	191202	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	155145976	191235	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4846676	191235	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	155154008	191253	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4846959	191253	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154202	191268	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4847181	191268	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153982	191278	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	CHEMBL4847374	191278	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	7015981	191336	31	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	CHEMBL4848369	191336	31	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	155154180	191362	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4848664	191362	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	114322379	191371	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4848825	191371	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155153838	191399	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	CHEMBL4849270	191399	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	155153758	191425	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	CHEMBL4849588	191425	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	155153970	191455	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	CHEMBL4849913	191455	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	155154172	191508	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4850633	191508	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	155154044	191583	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4851715	191583	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155145940	191793	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4854872	191793	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	84614649	191813	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	CHEMBL4855127	191813	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	155153740	191832	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4855384	191832	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	107881084	191845	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	CHEMBL4855567	191845	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	155154045	191881	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856071	191881	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146040	191903	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4856356	191903	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145911	191936	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4857097	191936	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	102723930	191937	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	CHEMBL4857110	191937	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	155154009	191938	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4857124	191938	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155153960	191985	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	CHEMBL4857656	191985	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	155153995	192056	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	CHEMBL4858920	192056	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	155153774	192064	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4859063	192064	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155154005	192070	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	CHEMBL4859171	192070	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	155146005	192072	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4859266	192072	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903220	192097	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	CHEMBL4859510	192097	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	155153791	192117	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	CHEMBL4859833	192117	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	155154252	192118	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4859840	192118	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155154021	192130	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4860115	192130	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154007	192247	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861940	192247	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	22682941	192280	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	CHEMBL4862434	192280	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	155153807	192335	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	CHEMBL4863225	192335	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	155153800	192377	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	CHEMBL4863762	192377	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	43531176	192397	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4864076	192397	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	137553505	192406	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4864265	192406	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155154133	192453	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	CHEMBL4865044	192453	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	7022231	192517	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866106	192517	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	113925944	192524	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	CHEMBL4866201	192524	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	155153793	192527	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	CHEMBL4866223	192527	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	29080666	192543	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	CHEMBL4866428	192543	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	155154248	192559	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4866577	192559	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155153775	192573	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	CHEMBL4866840	192573	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	155145950	192622	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4867568	192622	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155153837	192624	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	CHEMBL4867604	192624	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	155146125	192630	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4867684	192630	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	43092667	192633	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4867744	192633	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155154000	192649	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4868055	192649	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	155154006	192661	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4868255	192661	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153812	192703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	CHEMBL4869118	192703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	155153736	192718	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	CHEMBL4869336	192718	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	155154048	192719	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869352	192719	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153773	192748	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	CHEMBL4869694	192748	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	155154141	192817	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	CHEMBL4870727	192817	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	155154020	192833	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4870998	192833	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154205	192859	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871418	192859	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154075	192906	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871892	192906	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153810	192914	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4872055	192914	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153994	192931	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	CHEMBL4872342	192931	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	155154215	192958	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4872646	192958	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154082	192964	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	CHEMBL4872725	192964	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	890775	192989	35	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873123	192989	35	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584777	193009	46	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	CHEMBL4873423	193009	46	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	155154016	193034	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4873773	193034	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153999	193048	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873923	193048	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155146134	193049	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4873967	193049	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	155146091	193096	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4874662	193096	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153987	193136	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875200	193136	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	156048221	193140	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4875343	193140	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154219	193143	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875377	193143	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	832097	193233	30	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	CHEMBL4876586	193233	30	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	155153971	193247	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	CHEMBL4876749	193247	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	155145974	193261	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4876954	193261	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	7015989	193262	32	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4877006	193262	32	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	155154019	193274	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877244	193274	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154178	193275	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877261	193275	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145948	193353	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878337	193353	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153809	193361	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4878428	193361	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153794	193391	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	CHEMBL4879041	193391	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	929494	45777	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	CHEMBL1468323	45777	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	725872	49369	40	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	CHEMBL1500515	49369	40	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	891145	58824	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1587117	58824	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155146121	191214	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4846341	191214	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	17605178	191317	21	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	CHEMBL4847901	191317	21	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	7015983	191350	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	CHEMBL4848511	191350	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	155154010	191356	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	CHEMBL4848586	191356	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	155146163	191572	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4851598	191572	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	28542041	191575	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	CHEMBL4851647	191575	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	155154015	191599	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	CHEMBL4851939	191599	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	155154056	191601	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4851949	191601	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	155154148	191608	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	CHEMBL4852032	191608	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	22682321	191672	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4852959	191672	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	11472211	191823	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	CHEMBL4855304	191823	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	15487504	191847	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4855628	191847	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	116688442	191895	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	CHEMBL4856288	191895	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	155154083	191947	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4857218	191947	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155153972	192013	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	CHEMBL4858105	192013	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	155146161	192049	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4858773	192049	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	65339188	192063	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4859048	192063	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	13013688	192085	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4859370	192085	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	155146132	192124	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	CHEMBL4860022	192124	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	155153997	192233	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4861721	192233	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	63531317	192250	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4861974	192250	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	24225858	192255	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	CHEMBL4862041	192255	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	155153755	192271	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4862314	192271	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	155153805	192331	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4863173	192331	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	155154003	192341	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863275	192341	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	155154024	192379	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	CHEMBL4863823	192379	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	17605176	192381	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863854	192381	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584738	192403	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	CHEMBL4864171	192403	34	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	155154171	192420	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	CHEMBL4864441	192420	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	20991272	192574	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866841	192574	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	20985043	192578	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	CHEMBL4866888	192578	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	721137	192586	50	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	CHEMBL4866984	192586	50	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	155153808	192645	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	CHEMBL4868006	192645	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	82096332	192692	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4868865	192692	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	155153803	192747	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869674	192747	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153783	192795	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4870496	192795	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155154195	192799	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4870512	192799	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	8977162	192867	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	CHEMBL4871542	192867	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	155153984	192881	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4871699	192881	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	3288323	192891	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4871766	192891	33	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155153862	192946	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4872542	192946	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155146072	192969	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4872766	192969	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	155153991	193041	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4873848	193041	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	14974397	193059	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4874104	193059	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	155154050	193070	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4874272	193070	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	81781305	193181	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4875899	193181	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	155146174	193213	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4876298	193213	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154076	193268	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	CHEMBL4877160	193268	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	155153754	193362	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	CHEMBL4878462	193362	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	155154070	193399	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4879226	193399	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	155154170	191527	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155145968	191804	5	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154002	191647	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	191647	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	192887	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153792	192604	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	4366362	191464	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	4366362	191464	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	191804	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146009	193132	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	193132	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	193159	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	193159	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145968	191804	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146136	193317	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155146147	193159	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	193159	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153902	192086	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	192086	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145946	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153934	192832	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	CHEMBL4870947	192832	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	155154002	191647	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	191647	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	192887	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	193023	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	193023	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	155153792	192604	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153902	192086	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	192086	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	193132	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	193132	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	193159	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	193159	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153792	192604	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155145946	192050	6	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	192887	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146136	193317	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145968	191804	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146147	193159	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	193159	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155154002	191647	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	191647	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146067	191386	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	191386	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155145900	192887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145968	191804	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	106903214	193023	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	193023	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	191464	37	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	191918	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	191918	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	192604	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153792	192604	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155146136	193317	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	191918	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	191918	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153902	192086	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	192086	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	107119671	191630	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	191630	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155146067	191386	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	191386	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146136	193317	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	192050	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	192887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	193132	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	193132	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146047	193376	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	193376	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155146009	193132	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	193132	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146136	193317	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155146136	193317	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	193317	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	191918	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	191918	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146147	193159	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	193159	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	4366362	191464	37	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	191918	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	191918	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146009	193132	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	193132	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155153902	192086	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	192086	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153902	192086	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	192086	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	193023	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	193023	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	191464	37	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155153780	193084	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	193084	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154170	191527	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154170	191527	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	890753	38392	39	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	CHEMBL1404550	38392	39	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	155146086	191275	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	CHEMBL4847344	191275	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	155146130	191290	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	CHEMBL4847516	191290	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	155154149	191293	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4847582	191293	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155153911	191441	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	CHEMBL4849736	191441	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	155146026	191511	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4850676	191511	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	155154004	191513	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	CHEMBL4850688	191513	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	19619635	191570	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4851582	191570	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	91105735	191573	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	CHEMBL4851614	191573	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	903815	191578	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL4851668	191578	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	155153785	191579	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4851669	191579	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	155154017	191677	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4852989	191677	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	4442182	191679	41	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	CHEMBL4853044	191679	41	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	103238459	191713	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	CHEMBL4853544	191713	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	155154052	191733	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4853811	191733	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146123	191840	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4855464	191840	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155784453	191885	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856138	191885	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146049	191887	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856167	191887	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154204	191897	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856296	191897	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154013	191931	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	CHEMBL4857004	191931	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	155153735	192040	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	CHEMBL4858571	192040	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	155153998	192104	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	CHEMBL4859587	192104	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	155153813	192200	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861329	192200	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154400	192205	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861423	192205	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154049	192209	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4861439	192209	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154027	192212	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	CHEMBL4861452	192212	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	155146107	192251	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4861980	192251	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154040	192370	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	CHEMBL4863644	192370	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	155153798	192423	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4864507	192423	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154046	192428	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4864569	192428	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903207	192430	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	CHEMBL4864640	192430	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	155153702	192525	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	CHEMBL4866218	192525	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	62669913	192557	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4866560	192557	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155153739	192617	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4867549	192617	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153757	192654	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4868173	192654	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	19620501	192672	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4868548	192672	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	155701700	192691	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	CHEMBL4868856	192691	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	155153801	192699	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	CHEMBL4869062	192699	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	155153802	192898	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	CHEMBL4871829	192898	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	155154216	192908	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871932	192908	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154203	192945	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	CHEMBL4872532	192945	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	155154200	192971	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	CHEMBL4872809	192971	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	155146160	193067	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	CHEMBL4874203	193067	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	155146102	193097	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	CHEMBL4874670	193097	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	29789593	193103	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4874777	193103	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	20984378	193237	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	CHEMBL4876625	193237	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	155154217	193263	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	CHEMBL4877028	193263	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	155154152	193280	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	CHEMBL4877399	193280	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	155153804	193329	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	CHEMBL4878001	193329	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	107119671	191630	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	191630	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	4366362	191464	37	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	191464	37	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	191804	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	191804	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146047	193376	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	193376	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153780	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146067	191386	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	191386	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146067	191386	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	191386	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155153780	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154251	191918	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	191918	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	192604	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	192604	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153780	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	193084	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	193376	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	193376	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	192050	6	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	192050	6	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155154170	191527	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	191647	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	191647	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153780	193084	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	193084	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	193376	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	193376	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	106903214	193023	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	193023	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	107119671	191630	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	191630	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155145900	192887	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	192887	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154170	191527	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	191527	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	191647	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	191647	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)