ArrestinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-MCPG	2475	None	35	Rat	Binding	pKi	None	-	3.80	-6	8	Unclassified	Guide to Pharmacology	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/12695537
(1R,2S)-PHENYLPROPANOLAMINE	27120	Functional	13	Rat	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(1S,3R)-ACPD	33	None	30	Human	Binding	EC50	=	15000.00	4.82	-26	15	Compound was tested for the inhibition of Metabotropic glutamate receptor 1	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm970719q
(1S,3R)-ACPD	33	None	30	Human	Binding	EC50	=	22000.00	4.66	-26	15	Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm9601718
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	5.80	3	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/12695537
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	5.80	3	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/7690672
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	5.80	3	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/11080213
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	22000.00	4.66	3	15	Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	50000.00	4.30	3	15	Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(S)-(+)-CBPG	3544	None	30	Human	Binding	IC50	=	32000.00	4.50	-	3	Inhibitory activity against mGluR1 receptor	ChEMBL	185.1	3	3	3	-0.35	N[C@H](C(=O)O)C12CC(C(=O)O)(C1)C2	https://dx.doi.org/10.1016/s0960-894x(98)00265-0
(S)-(+)-CBPG	3544	None	30	Human	Binding	IC50	=	25000.00	4.60	-	3	Inhibition of mGluR1a receptor	ChEMBL	185.1	3	3	3	-0.35	N[C@H](C(=O)O)C12CC(C(=O)O)(C1)C2	https://dx.doi.org/10.1021/jm1013693
(S)-(+)-CBPG	3544	None	30	Human	Binding	IC50	=	25000.00	4.60	-	3	Antagonist activity at mGluR1alpha (unknown origin)	ChEMBL	185.1	3	3	3	-0.35	N[C@H](C(=O)O)C12CC(C(=O)O)(C1)C2	https://dx.doi.org/10.1021/acs.jmedchem.1c01215
(S)-(+)-CBPG	3544	None	30	Rat	Binding	IC50	=	25000.00	4.60	-	3	Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.	ChEMBL	185.1	3	3	3	-0.35	N[C@H](C(=O)O)C12CC(C(=O)O)(C1)C2	https://dx.doi.org/10.1021/jm980571q
(S)-3HPG	2080	None	32	Human	Binding	EC50	=	68000.00	4.17	-	3	Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)	ChEMBL	167.1	2	3	3	0.48	N[C@H](C(=O)O)c1cccc(O)c1	https://dx.doi.org/10.1021/jm9601718
(S)-4C3HPG	2081	None	25	Human	Binding	pKi	None	-	5.90	12	5	Unclassified	Guide to Pharmacology	211.0	3	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(O)c1	https://pubmed.ncbi.nlm.nih.gov/12695537
(S)-4C3HPG	2081	None	25	Human	Binding	pKi	None	-	5.90	12	5	Unclassified	Guide to Pharmacology	211.0	3	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(O)c1	https://pubmed.ncbi.nlm.nih.gov/11080213
(S)-4C3HPG	2081	None	25	Human	Binding	IC50	=	40000.00	4.40	12	5	Inhibitory concentration for half maximal inhibition of PI hydrolysis (mGluR1a)	ChEMBL	211.0	3	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(O)c1	https://dx.doi.org/10.1021/jm9601718
(S)-4C3HPG	2081	None	25	Rat	Binding	IC50	=	40000.00	4.40	-	5	Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells	ChEMBL	211.0	3	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(O)c1	https://dx.doi.org/10.1021/jm980571q
(S)-4CPG	3449	None	40	Human	Binding	IC50	=	65000.00	4.19	-21	3	Inhibitory concentration for half maximal inhibition of PI hydrolysis (mGluR1a)	ChEMBL	195.1	3	3	3	0.47	N[C@H](C(=O)O)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1021/jm9601718
(S)-4CPG	3449	None	40	Human	Binding	IC50	=	65000.00	4.19	-21	3	Antagonist activity at mGluR1alpha (unknown origin)	ChEMBL	195.1	3	3	3	0.47	N[C@H](C(=O)O)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.1c01215

Showing 1 to 20 of 466 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)