Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
|
GPCRdb(A)
|
TAS2R20
Human |
|
|---|---|---|
| TM1 | ||
| 1x28 | M2 | |
| 1x29 | S3 | |
| 1x30 | F4 | |
| 1x31 | L5 | |
| 1x32 | H6 | |
| 1x33 | I7 | |
| 1x34 | V8 | |
| 1x35 | F9 | |
| 1x36 | S10 | |
| 1x37 | I11 | |
| 1x38 | L12 | |
| 1x39 | V13 | |
| 1x40 | V14 | |
| 1x41 | V15 | |
| 1x42 | A16 | |
| 1x43 | F17 | |
| 1x44 | I18 | |
| 1x45 | L19 | |
| 1x46 | G20 | |
| 1x47 | N21 | |
| 1x48 | F22 | |
| 1x49 | A23 | |
| 1x50 | N24 | |
| 1x51 | G25 | |
| 1x52 | F26 | |
| 1x53 | I27 | |
| 1x54 | A28 | |
| 1x55 | L29 | |
| 1x56 | I30 | |
| 1x57 | N31 | |
| 1x58 | F32 | |
| 1x59 | I33 | |
| 1x60 | A34 | |
| 1x61 | W35 | |
| 1x62 | V36 | |
| 1x63 | K37 | |
| 1x64 | R38 | |
| 1x65 | Q39 | |
| TM2 | ||
| 2x37 | S42 | |
| 2x38 | S43 | |
| 2x39 | A44 | |
| 2x40 | D45 | |
| 2x41 | Q46 | |
| 2x42 | I47 | |
| 2x43 | I48 | |
| 2x44 | A49 | |
| 2x45 | A50 | |
| 2x46 | L51 | |
| 2x47 | A52 | |
| 2x48 | V53 | |
| 2x49 | S54 | |
| 2x50 | R55 | |
| 2x51 | V56 | |
| 2x52 | G57 | |
| 2x53 | L58 | |
| 2x54 | L59 | |
| 2x55 | W60 | |
| 2x56 | V61 | |
| 2x57 | I62 | |
| 2x58 | L63 | |
| 2x59 | L64 | |
| 2x60 | H65 | |
| 2x61 | W66 | |
| 2x62 | Y67 | |
| 2x63 | S68 | |
| 2x64 | T69 | |
| 2x65 | V70 | |
| 2x66 | L71 | |
| 2x67 | N72 | |
| TM3 | ||
| 3x21 | N77 | |
| 3x22 | L78 | |
| 3x23 | K79 | |
| 3x24 | V80 | |
| 3x25 | I81 | |
| 3x26 | I82 | |
| 3x27 | F83 | |
| 3x28 | I84 | |
| 3x29 | S85 | |
| 3x30 | N86 | |
| 3x31 | A87 | |
| 3x32 | W88 | |
| 3x33 | A89 | |
| 3x34 | V90 | |
| 3x35 | T91 | |
| 3x36 | N92 | |
| 3x37 | H93 | |
| 3x38 | F94 | |
| 3x39 | S95 | |
| 3x40 | I96 | |
| 3x41 | W97 | |
| 3x42 | L98 | |
| 3x43 | A99 | |
| 3x44 | T100 | |
| 3x45 | S101 | |
| 3x46 | L102 | |
| 3x47 | S103 | |
| 3x48 | I104 | |
| 3x49 | F105 | |
| 3x50 | Y106 | |
| 3x51 | L107 | |
| 3x52 | L108 | |
| 3x53 | K109 | |
| 3x54 | I110 | |
| 3x55 | V111 | |
| ICL2 | ||
| 34x44 | N112 | |
| 34x45 | F113 | |
| 34x46 | S114 | |
| 34x47 | R115 | |
| 34x48 | L116 | |
| 34x49 | I117 | |
| 34x50 | F118 | |
| 34x51 | H119 | |
| 34x52 | H120 | |
| 34x53 | L121 | |
| 34x54 | K122 | |
| 34x55 | R123 | |
| TM4 | ||
| 4x37 | K124 | |
| 4x38 | A125 | |
| 4x39 | K126 | |
| 4x40 | S127 | |
| 4x41 | V128 | |
| 4x42 | V129 | |
| 4x43 | L130 | |
| 4x44 | V131 | |
| 4x45 | I132 | |
| 4x46 | V133 | |
| 4x47 | L134 | |
| 4x48 | G135 | |
| 4x49 | S136 | |
| 4x50 | L137 | |
| 4x51 | F138 | |
| 4x52 | F139 | |
| 4x53 | L140 | |
| 4x54 | V141 | |
| 4x55 | C142 | |
| 4x56 | H143 | |
| 4x57 | L144 | |
| 4x58 | V145 | |
| 4x59 | M146 | |
| 4x60 | K147 | |
| 4x61 | H148 | |
| 4x62 | T149 | |
| 4x63 | Y150 | |
| 4x64 | I151 | |
| 4x65 | N152 | |
| TM5 | ||
| 5x40 | N176 | |
| 5x41 | L177 | |
| 5x42 | T178 | |
| 5x43 | V179 | |
| 5x44 | A180 | |
| 5x45 | M181 | |
| 5x46 | L182 | |
| 5x461 | A183 | |
| 5x47 | N184 | |
| 5x48 | L185 | |
| 5x49 | I186 | |
| 5x50 | P187 | |
| 5x51 | F188 | |
| 5x52 | T189 | |
| 5x53 | L190 | |
| 5x54 | T191 | |
| 5x55 | L192 | |
| 5x56 | I193 | |
| 5x57 | S194 | |
| 5x58 | F195 | |
| 5x59 | L196 | |
| 5x60 | L197 | |
| 5x61 | L198 | |
| 5x62 | I199 | |
| 5x63 | Y200 | |
| 5x64 | S201 | |
| 5x65 | L202 | |
| 5x66 | C203 | |
| 5x67 | K204 | |
| 5x68 | H205 | |
| 5x69 | L206 | |
| 5x70 | K207 | |
| 5x71 | K208 | |
| 5x72 | M209 | |
| 5x73 | Q210 | |
| 5x74 | L211 | |
| 5x75 | H212 | |
| 5x76 | G213 | |
| TM6 | ||
| 6x25 | D218 | |
| 6x26 | P219 | |
| 6x27 | S220 | |
| 6x28 | T221 | |
| 6x29 | K222 | |
| 6x30 | I223 | |
| 6x31 | H224 | |
| 6x32 | I225 | |
| 6x33 | K226 | |
| 6x34 | A227 | |
| 6x35 | L228 | |
| 6x36 | Q229 | |
| 6x37 | T230 | |
| 6x38 | V231 | |
| 6x39 | T232 | |
| 6x40 | S233 | |
| 6x41 | F234 | |
| 6x42 | L235 | |
| 6x43 | I236 | |
| 6x44 | L237 | |
| 6x45 | L238 | |
| 6x46 | A239 | |
| 6x47 | I240 | |
| 6x48 | Y241 | |
| 6x49 | F242 | |
| 6x50 | L243 | |
| 6x51 | C244 | |
| 6x52 | L245 | |
| 6x53 | I246 | |
| 6x54 | I247 | |
| 6x55 | S248 | |
| 6x56 | F249 | |
| 6x57 | W250 | |
| 6x58 | N251 | |
| 6x59 | F252 | |
| 6x60 | K253 | |
| 6x61 | M254 | |
| TM7 | ||
| 7x31 | E258 | |
| 7x32 | I259 | |
| 7x33 | V260 | |
| 7x34 | L261 | |
| 7x35 | M262 | |
| 7x36 | L263 | |
| 7x37 | C264 | |
| 7x38 | Q265 | |
| 7x39 | A266 | |
| 7x40 | F267 | |
| 7x41 | G268 | |
| 7x42 | I269 | |
| 7x43 | I270 | |
| 7x45 | Y271 | |
| 7x46 | P272 | |
| 7x47 | S273 | |
| 7x48 | F274 | |
| 7x49 | H275 | |
| 7x50 | S276 | |
| 7x51 | F277 | |
| 7x52 | I278 | |
| 7x53 | L279 | |
| 7x54 | I280 | |
| 7x55 | W281 | |
| 7x56 | G282 | |
| H8 | ||
| 8x47 | N283 | |
| 8x48 | K284 | |
| 8x49 | T285 | |
| 8x50 | L286 | |
| 8x51 | K287 | |
| 8x52 | Q288 | |
| 8x53 | T289 | |
| 8x54 | F290 | |
| 8x55 | L291 | |
| 8x56 | S292 | |
| 8x57 | V293 | |
| 8x58 | L294 | |
| 8x59 | W295 | |
| 8x60 | Q296 | |
| 8x61 | V297 | |
| 8x62 | T298 | |
| 8x63 | C299 | |
| 8x64 | W300 | |
| 8x65 | A301 | |