NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6OSA

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-019-1337-6

PUBLICATION DATE

July 10, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

54 interactions (Click to see)

LIGANDS

JMV449 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

large neuromedin N, neuromedin N, neurotensin, large neurotensin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 266 5x68 G.H5 I 344 G.H5.16
Polar H8 N 370 8x49 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 N 370 8x49 G.h4s6 T 316 G.h4s6.10
Polar TM6 G 280 6x22 G.H5 K 345 G.H5.17
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 169 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 298 6x30 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 279 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 279 - G.S6 Y 320 G.S6.02
Polar H8 N 370 8x49 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 L 263 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 297 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 177 34x54 G.hns1 A 31 G.hns1.02
Polar ICL1 S 93 - G.h3s5 T 260 G.h3s5.01
Hydrophobic ICL1 S 93 - G.h3s5 T 260 G.h3s5.01
Van-der-waals ICL1 S 93 - G.h3s5 T 260 G.h3s5.01
Ionic H8 H 373 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 H 373 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 H 373 8x52 G.h4s6 D 315 G.h4s6.09
Ionic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 178 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 T 178 34x55 G.HN G 27 G.HN.51
Hydrophobic TM6 R 294 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 294 6x26 G.H5 I 344 G.H5.16
Polar TM6 G 280 6x22 G.H5 D 341 G.H5.13
Hydrophobic TM6 G 280 6x22 G.H5 D 341 G.H5.13
Van-der-waals TM6 G 280 6x22 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 170 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 170 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 170 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Aromatic ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 294 6x26 G.H5 K 345 G.H5.17
Polar ICL1 L 94 - G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL3 T 278 - G.H5 D 337 G.H5.09
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 101 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Hydrophobic ICL1 L 94 - G.h2s4 E 216 G.h2s4.02
Van-der-waals ICL1 L 94 - G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL2 F 174 34x51 G.hns1 A 31 G.hns1.02
Polar ICL1 S 93 - G.H3 K 257 G.H3.16
Hydrophobic TM7 V 367 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 V 367 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 101 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 263 5x65 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 293 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL1 L 94 - G.h2s4 G 217 G.h2s4.03
Polar H8 S 368 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 S 368 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 368 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL3 V 279 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 279 - G.H5 F 334 G.H5.06