CRF2 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

P

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6PB1

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.MOLCEL.2020.01.013

PUBLICATION DATE

Feb. 12, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

Urocortin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

corticotrophin-releasing hormone, urocortin 1, urocortin 3, urocortin 2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 T 216 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 T 219 - G.H5 H 387 G.H5.19
Polar TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 293 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 Y 217 - G.S1 H 41 G.S1.02
Polar TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 290 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 T 216 - G.H5 R 380 G.H5.12
Hydrophobic TM7 F 358 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 311 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 217 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 217 - G.S3 V 217 G.S3.01
Polar TM5 K 293 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 293 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 293 5x64 G.H5 L 388 G.H5.20
Polar TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Polar ICL3 S 297 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 S 297 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 L 294 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 307 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 307 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 290 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 220 - G.hns1 A 39 G.hns1.03
Polar TM3 V 214 3x59 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 214 3x59 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 315 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 T 216 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 212 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 213 3x58 G.H5 L 388 G.H5.20
Polar ICL3 S 297 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 297 - G.H5 R 385 G.H5.17
Hydrophobic TM5 L 290 5x61 G.H5 L 388 G.H5.20
Ionic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 E 220 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 220 - G.hns1 R 38 G.hns1.02
Polar ICL2 Y 217 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 217 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 217 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 217 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 217 - G.S3 F 219 G.S3.03
Polar ICL2 Y 217 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 217 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Hydrophobic H8 N 363 8x47 G.H5 E 392 G.H5.24