CXCR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IC0

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41467-023-39799-2

PUBLICATION DATE

July 19, 2023

3D VIEW

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LIGAND INTERACTIONS

59 interactions (Click to see)

LIGANDS

Interleukin-8 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

CXCL8, cytokine domain of tyrosyl tRNA synthetase, CXCL6



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 A 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 240 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 144 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 144 - G.H5 N 347 G.H5.19
Polar TM3 R 135 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 143 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 T 143 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 R 150 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 150 - G.HN E 28 G.HN.52
Hydrophobic TM3 I 139 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 244 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 244 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 N 311 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 311 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL3 G 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 G 235 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 139 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 139 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 142 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 H 233 - G.S6 Y 320 G.S6.02
Polar H8 Q 310 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 Q 310 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 310 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 G 309 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 138 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 229 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 240 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 139 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 139 3x54 G.H5 L 353 G.H5.25
Ionic ICL3 H 233 - G.H5 D 341 G.H5.13
Polar ICL3 H 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 233 - G.H5 D 341 G.H5.13
Polar ICL3 M 234 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 234 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 234 - G.H5 D 341 G.H5.13
Polar ICL2 R 144 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 144 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 144 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 143 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 Q 236 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 Q 236 - G.H5 F 354 G.H5.26
Polar H8 N 311 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 311 8x49 G.H5 D 350 G.H5.22
Aromatic ICL2 H 151 - G.HN R 24 G.HN.48
Hydrophobic ICL2 A 142 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 142 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 234 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 143 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 T 143 - G.H5 T 340 G.H5.12
Hydrophobic TM2 T 74 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 74 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 240 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 234 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 R 144 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 144 - G.H5 I 343 G.H5.15
Polar TM2 S 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 72 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 243 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 150 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 150 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 135 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 135 3x50 G.H5 L 353 G.H5.25