G12 - 5-HT2B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 W 261 - G.H5 E 357 G.H5.02
Hydrophobic ICL3 W 261 - G.H5 E 357 G.H5.02
Hydrophobic TM5 L 244 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term R 411 - G.h4s6 K 344 G.h4s6.19
Van-der-waals C-term R 411 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 A 322 6x33 G.H5 L 375 G.H5.20
Polar ICL2 N 164 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 164 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 157 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 156 3x53 G.H5 I 378 G.H5.23
Aromatic ICL3 W 261 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 W 261 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 W 261 - G.S6 H 349 G.S6.04
Polar TM3 K 158 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 K 158 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL3 T 260 - G.HG M 298 G.HG.01
Van-der-waals ICL3 T 260 - G.HG M 298 G.HG.01
Polar TM6 T 315 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 315 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 T 315 6x26 G.H5 Q 372 G.H5.17
Polar C-term K 410 - G.H5 Q 381 G.H5.26
Hydrophobic C-term K 410 - G.H5 Q 381 G.H5.26
Van-der-waals C-term K 410 - G.H5 Q 381 G.H5.26
Hydrophobic ICL3 T 307 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 T 307 - G.H5 F 361 G.H5.06
Van-der-waals ICL2 Q 165 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL3 G 309 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 I 161 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 I 161 34x51 G.H5 I 370 G.H5.15
Polar C-term R 418 - G.H3 K 284 G.H3.16
Van-der-waals C-term R 418 - G.H3 K 284 G.H3.16
Polar C-term R 411 - G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term R 411 - G.h3s5 N 288 G.h3s5.02
Van-der-waals C-term R 411 - G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 L 326 6x37 G.H5 I 378 G.H5.23
Polar ICL2 P 160 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 160 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 160 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 N 164 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 259 - G.H4 E 325 G.H4.05
Van-der-waals ICL3 L 259 - G.H4 E 325 G.H4.05
Hydrophobic TM7 F 383 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 F 383 7x56 G.H5 M 379 G.H5.24
Polar H8 N 384 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 384 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 384 8x47 G.H5 Q 381 G.H5.26
Polar ICL3 T 307 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 T 307 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 T 307 - G.S6 H 348 G.S6.03
Hydrophobic TM3 I 157 3x54 G.H5 L 371 G.H5.16
Polar H8 N 384 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 384 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 384 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 315 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM4 S 168 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 Y 380 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 380 7x53 G.H5 L 380 G.H5.25
Polar C-term R 411 - G.h3s5 F 287 G.h3s5.01
Aromatic C-term R 411 - G.h3s5 F 287 G.h3s5.01
Hydrophobic C-term R 411 - G.h3s5 F 287 G.h3s5.01
Van-der-waals C-term R 411 - G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 P 160 34x50 G.H5 L 371 G.H5.16
Polar ICL2 Q 165 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 165 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 165 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 Q 165 34x55 G.hns1 R 55 G.hns1.02
Polar TM6 N 318 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 318 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM5 K 247 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 247 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 E 319 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 319 6x30 G.H5 L 375 G.H5.20
Polar ICL3 T 260 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 T 260 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 T 260 - G.S6 H 349 G.S6.04
Hydrophobic TM6 A 322 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 322 6x33 G.H5 M 379 G.H5.24
Polar ICL2 N 167 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 167 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 167 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 160 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 160 34x50 G.H5 I 370 G.H5.15
Polar ICL2 N 164 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 N 164 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL3 G 309 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 G 309 - G.S6 H 348 G.S6.03
Hydrophobic TM7 F 383 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 383 7x56 G.H5 L 380 G.H5.25
Ionic ICL3 K 311 - G.H5 D 368 G.H5.13
Polar ICL3 K 311 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 K 311 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 K 311 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 Y 166 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 166 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 I 161 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 I 308 - G.H5 F 361 G.H5.06
Hydrophobic C-term P 420 - G.H3 K 284 G.H3.16
Van-der-waals C-term P 420 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 I 161 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL3 W 261 - G.H5 F 361 G.H5.06
Hydrophobic C-term F 417 - G.H3 L 285 G.H3.17
Van-der-waals C-term F 417 - G.H3 L 285 G.H3.17
Hydrophobic C-term I 415 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 415 - G.H3 K 284 G.H3.16
Polar C-term Y 416 - G.H3 K 284 G.H3.16
Hydrophobic C-term I 415 - G.H3 L 285 G.H3.17
Van-der-waals C-term I 415 - G.H3 L 285 G.H3.17
Hydrophobic TM6 R 321 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 321 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL3 T 307 - G.S6 F 350 G.S6.05
Polar TM3 R 153 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 153 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 153 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 161 34x51 G.H5 F 363 G.H5.08
Polar TM6 E 319 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 319 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 T 307 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 I 308 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 I 161 34x51 G.S1 V 58 G.S1.02
Polar C-term S 412 - G.h3s5 N 288 G.h3s5.02
Van-der-waals C-term S 412 - G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 N 318 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 318 6x29 G.H5 M 379 G.H5.24
Polar TM3 A 156 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 156 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 156 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL3 S 312 - G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 321 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 160 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 160 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 G 309 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 G 309 - G.S6 L 346 G.S6.01
Hydrophobic TM3 I 157 3x54 G.H5 I 378 G.H5.23