Gi2 - 5-HT2C receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 294 - G.H4 S 302 G.H4.08
Hydrophobic ICL3 R 294 - G.H4 S 302 G.H4.08
Van-der-waals ICL3 R 294 - G.H4 S 302 G.H4.08
Hydrophobic TM6 N 305 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 N 305 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 N 305 6x29 G.H5 L 349 G.H5.20
Hydrophobic C-term V 395 - G.H3 K 258 G.H3.16
Van-der-waals C-term V 395 - G.H3 K 258 G.H3.16
Polar TM6 Q 301 6x25 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 Q 301 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 L 313 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 L 349 G.H5.20
Ionic ICL3 R 294 - G.H4 D 298 G.H4.04
Polar ICL3 R 294 - G.H4 D 298 G.H4.04
Hydrophobic ICL3 R 294 - G.H4 D 298 G.H4.04
Van-der-waals ICL3 R 294 - G.H4 D 298 G.H4.04
Polar TM2 N 86 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM6 Q 301 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 301 6x25 G.h4s6 E 319 G.h4s6.12
Ionic C-term K 392 - G.h2s4 E 217 G.h2s4.02
Polar C-term K 392 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term K 392 - G.h2s4 E 217 G.h2s4.02
Polar TM6 N 305 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 N 305 6x29 G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 294 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 R 294 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 R 294 - G.H4 Q 305 G.H4.12
Hydrophobic ICL2 I 160 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 160 34x51 G.S3 L 195 G.S3.01
Polar C-term S 407 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term S 407 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL3 G 298 - G.h4s6 E 319 G.h4s6.12
Polar ICL2 H 162 34x53 G.H5 N 348 G.H5.19
Polar H8 N 372 8x47 G.H5 K 350 G.H5.21
Hydrophobic ICL3 P 296 - G.S6 T 322 G.S6.03
Hydrophobic C-term S 407 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term S 407 - G.s4h3 D 238 G.s4h3.11
Polar TM2 T 88 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 T 88 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 88 2x39 G.H5 D 351 G.H5.22
Hydrophobic C-term V 413 - G.H3 S 253 G.H3.11
Hydrophobic TM3 R 152 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 152 3x50 G.H5 L 354 G.H5.25
Polar C-term N 412 - G.H2 E 208 G.H2.03
Polar TM3 A 155 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 348 G.H5.19
Ionic C-term R 409 - G.s4h3 E 237 G.s4h3.10
Polar C-term R 409 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term R 409 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term R 409 - G.s4h3 E 237 G.s4h3.10
Aromatic ICL3 R 294 - G.S6 F 324 G.S6.05
Hydrophobic ICL3 R 294 - G.S6 F 324 G.S6.05
Ionic ICL3 R 297 - G.H4 E 309 G.H4.16
Polar ICL3 R 297 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 297 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 I 160 34x51 G.H5 F 337 G.H5.08
Hydrophobic C-term R 409 - G.H2 R 206 G.H2.01
Van-der-waals C-term R 409 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 R 164 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 164 34x55 G.S3 L 195 G.S3.01
Polar ICL2 R 164 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 R 164 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 164 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM6 A 309 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 309 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 159 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term L 411 - G.H3 E 246 G.H3.04
Hydrophobic TM6 A 302 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM7 F 371 7x56 G.H5 F 355 G.H5.26
Hydrophobic TM6 V 312 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 312 6x36 G.H5 L 354 G.H5.25
Polar ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 411 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 411 - G.H2 R 209 G.H2.04
Polar TM6 A 309 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 309 6x33 G.H5 L 354 G.H5.25
Polar C-term Y 416 - G.H3 K 258 G.H3.16
Hydrophobic C-term Y 416 - G.H3 K 258 G.H3.16
Van-der-waals C-term Y 416 - G.H3 K 258 G.H3.16
Polar ICL3 R 294 - G.H4 Y 297 G.H4.03
Hydrophobic ICL3 R 294 - G.H4 Y 297 G.H4.03
Polar ICL3 G 298 - G.S6 I 320 G.S6.01
Hydrophobic ICL3 G 298 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 G 298 - G.S6 I 320 G.S6.01
Polar TM3 R 152 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 352 G.H5.23
Polar TM6 K 308 6x32 G.H5 F 355 G.H5.26
Aromatic TM6 K 308 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 308 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 308 6x32 G.H5 F 355 G.H5.26
Polar C-term H 418 - G.h4s6 R 314 G.h4s6.04
Van-der-waals C-term H 418 - G.h4s6 R 314 G.h4s6.04
Hydrophobic ICL3 G 298 - G.S6 Y 321 G.S6.02
Ionic C-term R 400 - G.H2 E 208 G.H2.03
Polar C-term R 400 - G.H2 E 208 G.H2.03
Hydrophobic TM3 A 155 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 159 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 Q 244 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 244 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL3 R 294 - G.H4 A 301 G.H4.07
Van-der-waals ICL3 R 294 - G.H4 A 301 G.H4.07
Polar ICL2 P 159 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 159 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 I 160 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 I 156 3x54 G.H5 L 354 G.H5.25
Ionic ICL3 R 297 - G.H4 D 310 G.H4.17
Polar ICL3 R 297 - G.H4 D 310 G.H4.17
Van-der-waals ICL3 R 297 - G.H4 D 310 G.H4.17
Hydrophobic ICL2 S 163 34x54 G.H5 I 344 G.H5.15