G12 - α2A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 383 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 I 237 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 A 238 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 146 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 A 153 34x50 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 Q 372 G.H5.17
Polar ICL2 L 158 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 158 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 158 34x55 G.hns1 R 56 G.hns1.03
Ionic ICL3 R 376 - G.H4 D 336 G.H4.16
Polar ICL3 R 376 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 376 - G.H4 D 336 G.H4.16
Polar ICL2 N 157 34x54 G.H5 N 374 G.H5.19
Ionic TM5 R 241 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM7 Y 441 7x53 G.H5 L 380 G.H5.25
Polar H8 N 445 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 445 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 445 8x47 G.H5 L 380 G.H5.25
Polar TM3 S 149 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 P 246 5x73 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 246 5x73 G.S6 F 347 G.S6.02
Hydrophobic TM5 R 241 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL2 I 154 34x51 G.H5 K 367 G.H5.12
Van-der-waals TM4 P 162 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 S 247 5x74 G.S6 H 348 G.S6.03
Polar TM2 Q 83 2x39 G.H5 D 377 G.H5.22
Polar TM5 R 241 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 241 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 L 371 G.H5.16
Ionic ICL3 D 252 - G.H4 R 329 G.H4.09
Polar ICL3 D 252 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 D 252 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 D 252 - G.H4 R 329 G.H4.09
Hydrophobic TM6 F 387 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 387 6x33 G.H5 M 379 G.H5.24
Polar TM5 R 241 5x68 G.H5 K 367 G.H5.12
Polar H8 H 446 8x48 G.H5 L 380 G.H5.25
Van-der-waals ICL2 N 157 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 150 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 150 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 154 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 154 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 A 153 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 I 154 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 150 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 150 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 150 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 F 387 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM7 F 444 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 444 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM5 P 246 5x73 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 P 246 5x73 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 I 154 34x51 G.H5 F 363 G.H5.08