G12 - CRF1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM4 A 247 4x61 G.H5 K 367 G.H5.12
Polar TM4 K 250 4x64 G.H5 K 367 G.H5.12
Hydrophobic TM4 K 250 4x64 G.H5 K 367 G.H5.12
Van-der-waals TM4 K 250 4x64 G.H5 K 367 G.H5.12
Polar TM2 L 174 2x69 G.H5 N 374 G.H5.19
Van-der-waals TM2 L 174 2x69 G.H5 N 374 G.H5.19
Polar ECL1 V 180 - G.H5 D 377 G.H5.22
Hydrophobic ECL1 V 180 - G.H5 D 377 G.H5.22
Van-der-waals ECL1 V 180 - G.H5 D 377 G.H5.22
Hydrophobic TM4 K 250 4x64 G.S3 F 223 G.S3.03
Hydrophobic TM2 W 169 2x64 G.H3 L 285 G.H3.17
Hydrophobic TM2 A 167 2x62 G.H3 K 284 G.H3.16
Van-der-waals TM2 A 167 2x62 G.H3 K 284 G.H3.16
Hydrophobic TM2 L 150 2x45 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 L 150 2x45 G.hns1 R 55 G.hns1.02
Polar TM4 K 250 4x64 G.H5 F 363 G.H5.08
Aromatic TM4 K 250 4x64 G.H5 F 363 G.H5.08
Hydrophobic TM4 K 250 4x64 G.H5 F 363 G.H5.08
Van-der-waals TM4 K 250 4x64 G.H5 F 363 G.H5.08
Hydrophobic H8 A 392 8x72 G.H5 L 380 G.H5.25
Hydrophobic TM2 V 172 2x67 G.h2s4 G 244 G.h2s4.03
Hydrophobic TM2 F 170 2x65 G.H3 L 285 G.H3.17
Hydrophobic TM4 I 242 4x56 G.H5 I 378 G.H5.23
Van-der-waals TM4 I 242 4x56 G.H5 I 378 G.H5.23
Polar TM2 L 150 2x45 G.HN R 51 G.HN.51
Hydrophobic TM2 L 150 2x45 G.HN R 51 G.HN.51
Van-der-waals TM2 L 150 2x45 G.HN R 51 G.HN.51
Polar TM2 W 169 2x64 G.H3 K 284 G.H3.16
Hydrophobic TM2 W 169 2x64 G.H3 K 284 G.H3.16
Van-der-waals TM2 W 169 2x64 G.H3 K 284 G.H3.16
Hydrophobic TM4 D 254 4x68 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 D 254 4x68 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 T 326 6x52 G.H5 L 375 G.H5.20
Ionic TM6 T 326 6x52 G.H5 D 368 G.H5.13
Polar TM6 T 326 6x52 G.H5 D 368 G.H5.13
Hydrophobic TM6 T 326 6x52 G.H5 D 368 G.H5.13
Van-der-waals TM6 T 326 6x52 G.H5 D 368 G.H5.13
Hydrophobic TM4 K 250 4x64 G.S3 I 221 G.S3.01
Van-der-waals TM4 K 250 4x64 G.S3 I 221 G.S3.01
Hydrophobic TM6 L 323 6x49 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 326 6x52 G.H5 L 371 G.H5.16
Van-der-waals TM6 T 326 6x52 G.H5 L 371 G.H5.16
Polar TM4 Y 253 4x67 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 Y 253 4x67 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 Y 253 4x67 G.hns1 R 56 G.hns1.03
Polar TM2 V 171 2x66 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM2 V 171 2x66 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM2 V 171 2x66 G.h3s5 N 288 G.h3s5.02
Polar TM4 A 245 4x59 G.H5 N 374 G.H5.19
Van-der-waals TM4 A 245 4x59 G.H5 N 374 G.H5.19
Polar TM2 R 165 2x60 G.H3 K 284 G.H3.16
Van-der-waals TM2 R 165 2x60 G.H3 K 284 G.H3.16
Hydrophobic TM4 W 246 4x60 G.H5 L 375 G.H5.20
Hydrophobic TM4 Y 253 4x67 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 Y 253 4x67 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 W 169 2x64 G.h3s5 F 287 G.h3s5.01
Van-der-waals TM2 W 169 2x64 G.h3s5 F 287 G.h3s5.01
Hydrophobic TM4 G 249 4x63 G.H5 K 367 G.H5.12
Van-der-waals TM4 G 249 4x63 G.H5 K 367 G.H5.12
Polar C-term I 397 - G.H5 L 380 G.H5.25
Hydrophobic C-term I 397 - G.H5 L 380 G.H5.25
Van-der-waals C-term I 397 - G.H5 L 380 G.H5.25
Hydrophobic TM2 N 166 2x61 G.H3 K 284 G.H3.16
Hydrophobic TM4 W 246 4x60 G.H5 L 371 G.H5.16
Van-der-waals TM4 W 246 4x60 G.H5 L 371 G.H5.16
Hydrophobic C-term S 396 - G.H5 L 380 G.H5.25
Van-der-waals C-term S 396 - G.H5 L 380 G.H5.25
Hydrophobic C-term I 397 - G.H5 Q 381 G.H5.26
Van-der-waals C-term I 397 - G.H5 Q 381 G.H5.26
Ionic TM2 L 174 2x69 G.H5 D 377 G.H5.22
Polar TM2 L 174 2x69 G.H5 D 377 G.H5.22
Hydrophobic TM2 L 174 2x69 G.H5 D 377 G.H5.22
Van-der-waals TM2 L 174 2x69 G.H5 D 377 G.H5.22
Hydrophobic H8 V 391 8x71 G.H5 L 380 G.H5.25
Van-der-waals H8 V 391 8x71 G.H5 L 380 G.H5.25
Hydrophobic TM4 K 250 4x64 G.S1 V 58 G.S1.02
Van-der-waals TM2 W 169 2x64 G.h3s5 N 288 G.h3s5.02
Ionic TM2 L 174 2x69 G.H5 E 373 G.H5.18
Polar TM2 L 174 2x69 G.H5 E 373 G.H5.18
Hydrophobic TM2 L 174 2x69 G.H5 E 373 G.H5.18
Van-der-waals TM2 L 174 2x69 G.H5 E 373 G.H5.18
Hydrophobic TM4 G 249 4x63 G.H5 I 370 G.H5.15
Van-der-waals TM4 G 249 4x63 G.H5 I 370 G.H5.15
Hydrophobic TM4 G 249 4x63 G.H5 L 371 G.H5.16
Hydrophobic TM4 W 246 4x60 G.H5 I 378 G.H5.23
Van-der-waals TM4 W 246 4x60 G.H5 I 378 G.H5.23
Hydrophobic TM4 K 250 4x64 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 323 6x49 G.H5 M 379 G.H5.24
Hydrophobic TM4 K 250 4x64 G.H5 V 366 G.H5.11
Van-der-waals TM4 K 250 4x64 G.H5 V 366 G.H5.11
Hydrophobic TM2 R 151 2x46 G.h2s4 D 243 G.h2s4.02
Van-der-waals TM2 R 151 2x46 G.h2s4 D 243 G.h2s4.02
Hydrophobic TM6 L 322 6x48 G.H5 L 371 G.H5.16