Ggust - FZD5 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 23.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 W 348 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 348 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 K 442 - G.H5 K 345 G.H5.17
Van-der-waals TM4 N 350 4x35 G.H5 N 347 G.H5.19
Hydrophobic TM4 A 352 4x37 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 446 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 446 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 344 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 344 3x54 G.H5 L 348 G.H5.20
Polar TM4 Y 356 4x41 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 Y 356 4x41 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 I 433 5x76 G.H5 K 345 G.H5.17
Hydrophobic C-term L 563 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 563 - G.H3 L 249 G.H3.08
Polar TM2 E 268 2x41 G.H5 C 351 G.H5.23
Hydrophobic TM2 E 268 2x41 G.H5 C 351 G.H5.23
Van-der-waals TM2 E 268 2x41 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 426 5x69 G.H5 L 348 G.H5.20
Polar C-term Y 576 - G.hgh4 C 286 G.hgh4.01
Hydrophobic C-term Y 576 - G.hgh4 C 286 G.hgh4.01
Van-der-waals C-term Y 576 - G.hgh4 C 286 G.hgh4.01
Hydrophobic TM3 K 347 3x57 G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 443 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 443 - G.H5 F 354 G.H5.26
Polar TM4 N 350 4x35 G.H5 C 351 G.H5.23
Hydrophobic TM4 N 350 4x35 G.H5 C 351 G.H5.23
Van-der-waals TM4 N 350 4x35 G.H5 C 351 G.H5.23
Polar TM4 Y 359 4x44 G.HN Q 24 G.HN.48
Van-der-waals TM4 Y 359 4x44 G.HN Q 24 G.HN.48
Ionic TM3 K 347 3x57 G.H5 D 341 G.H5.13
Polar TM3 K 347 3x57 G.H5 D 341 G.H5.13
Van-der-waals TM3 K 347 3x57 G.H5 D 341 G.H5.13
Polar TM4 A 352 4x37 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 A 352 4x37 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 A 352 4x37 G.hns1 A 31 G.hns1.02
Polar TM6 R 449 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 449 6x32 G.H5 L 353 G.H5.25
Polar TM2 Y 266 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 266 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 266 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 429 5x72 G.H5 I 344 G.H5.16
Hydrophobic C-term L 563 - G.H3 S 252 G.H3.11
Polar C-term L 563 - G.H2 R 208 G.H2.04
Hydrophobic C-term L 563 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 563 - G.H2 R 208 G.H2.04
Hydrophobic ICL2 W 348 - G.H5 N 347 G.H5.19
Polar TM6 R 449 6x32 G.H5 G 352 G.H5.24
Polar C-term Y 556 - G.H3 Y 258 G.H3.17
Hydrophobic C-term Y 556 - G.H3 Y 258 G.H3.17
Van-der-waals C-term Y 556 - G.H3 Y 258 G.H3.17
Hydrophobic TM4 I 353 4x38 G.H5 C 351 G.H5.23
Polar TM4 Y 356 4x41 G.HN E 28 G.HN.52
Hydrophobic TM4 Y 356 4x41 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 356 4x41 G.HN E 28 G.HN.52
Hydrophobic C-term Y 556 - G.H2 I 212 G.H2.08
Van-der-waals C-term Y 556 - G.H2 I 212 G.H2.08
Hydrophobic TM3 K 347 3x57 G.H5 I 344 G.H5.16
Van-der-waals TM3 K 347 3x57 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 429 5x72 G.H5 L 348 G.H5.20
Hydrophobic ICL3 K 442 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 442 - G.H5 F 354 G.H5.26
Polar H8 K 525 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 446 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 446 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM3 W 340 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 340 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 267 2x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 343 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 343 3x53 G.H5 L 348 G.H5.20
Ionic C-term D 555 - G.H3 K 257 G.H3.16
Hydrophobic C-term A 559 - G.H3 H 256 G.H3.15
Van-der-waals C-term A 559 - G.H3 H 256 G.H3.15
Polar C-term Y 576 - G.s4h3 N 241 G.s4h3.15
Van-der-waals C-term Y 576 - G.s4h3 N 241 G.s4h3.15
Polar TM2 E 268 2x41 G.H5 L 353 G.H5.25
Hydrophobic TM2 E 268 2x41 G.H5 L 353 G.H5.25
Van-der-waals TM2 E 268 2x41 G.H5 L 353 G.H5.25
Hydrophobic TM7 W 520 7x55 G.H5 L 353 G.H5.25
Hydrophobic C-term L 563 - G.H3 I 253 G.H3.12
Polar TM4 N 350 4x35 G.H5 D 350 G.H5.22
Hydrophobic TM4 N 350 4x35 G.H5 D 350 G.H5.22
Van-der-waals TM4 N 350 4x35 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 450 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 450 6x33 G.H5 L 353 G.H5.25
Ionic ICL3 K 442 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 442 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 442 - G.h4s6 E 318 G.h4s6.12
Polar C-term Y 576 - G.s4h3 Y 230 G.s4h3.04
Polar C-term Y 576 - G.HG I 285 G.HG.17
Hydrophobic C-term Y 576 - G.HG I 285 G.HG.17
Van-der-waals C-term Y 576 - G.HG I 285 G.HG.17
Hydrophobic TM3 A 343 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 343 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term L 563 - G.H2 W 211 G.H2.07
Polar TM2 P 267 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 P 267 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 267 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 E 268 2x41 G.H5 G 352 G.H5.24
Van-der-waals TM2 E 268 2x41 G.H5 G 352 G.H5.24
Ionic C-term K 578 - H.HD E 145 H.HD.12
Polar C-term K 578 - H.HD E 145 H.HD.12
Hydrophobic C-term K 578 - H.HD E 145 H.HD.12
Van-der-waals C-term K 578 - H.HD E 145 H.HD.12
Hydrophobic TM4 E 351 4x36 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 G 349 4x34 G.H5 N 347 G.H5.19
Van-der-waals TM4 G 349 4x34 G.H5 N 347 G.H5.19
Hydrophobic C-term R 566 - G.s4h3 V 240 G.s4h3.14
Van-der-waals C-term R 566 - G.s4h3 V 240 G.s4h3.14
Hydrophobic C-term T 564 - G.H2 K 209 G.H2.05