Gz - GPR148 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 T 262 6x33 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 262 6x33 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 262 6x33 G.H5 G 353 G.H5.24
Hydrophobic ICL2 Y 156 34x53 G.H5 I 352 G.H5.23
Van-der-waals ICL2 Y 156 34x53 G.H5 I 352 G.H5.23
Hydrophobic TM3 H 145 3x49 G.H5 I 352 G.H5.23
Hydrophobic ICL3 S 249 - G.H5 D 342 G.H5.13
Polar ICL2 S 158 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 S 158 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 S 158 34x55 G.s2s3 E 194 G.s2s3.02
Polar TM6 R 258 6x29 G.H5 C 355 G.H5.26
Hydrophobic TM6 R 258 6x29 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 258 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 L 154 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 154 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM6 A 259 6x30 G.H5 C 355 G.H5.26
Van-der-waals TM6 A 259 6x30 G.H5 C 355 G.H5.26
Polar ICL2 P 153 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 153 34x50 G.H5 N 348 G.H5.19
Van-der-waals TM2 P 84 2x38 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 154 34x51 G.S3 F 197 G.S3.03
Polar TM2 H 85 2x39 G.H5 Y 351 G.H5.22
Aromatic TM2 H 85 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM2 H 85 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 H 85 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM3 T 146 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 T 146 3x50 G.H5 L 354 G.H5.25
Polar TM6 Q 254 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Q 254 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 254 6x25 G.h4s6 E 319 G.h4s6.12
Polar H8 R 323 8x53 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 157 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 M 160 34x57 G.H5 Y 351 G.H5.22
Van-der-waals ICL2 M 160 34x57 G.H5 Y 351 G.H5.22
Polar ICL1 Q 78 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 Q 78 12x48 G.HN D 20 G.HN.44
Hydrophobic TM3 T 146 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 T 146 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 154 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 154 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 R 258 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 R 258 6x29 G.H5 L 354 G.H5.25
Polar TM3 A 149 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 L 263 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 263 6x34 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 154 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 154 34x51 G.S3 L 195 G.S3.01
Polar H8 R 323 8x53 G.H5 G 353 G.H5.24
Hydrophobic ICL2 Y 156 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 Y 156 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 H 85 2x39 G.H5 I 352 G.H5.23
Ionic TM2 E 83 2x37 G.hns1 R 31 G.hns1.02
Polar TM2 E 83 2x37 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 E 83 2x37 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 E 83 2x37 G.hns1 R 31 G.hns1.02
Polar TM4 H 162 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 H 162 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 H 162 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL3 I 251 - G.H5 L 349 G.H5.20
Hydrophobic TM2 Q 82 2x36 G.HN R 24 G.HN.48
Polar TM6 T 262 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 262 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 262 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 V 150 3x54 G.H5 I 345 G.H5.16
Polar TM6 A 259 6x30 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 259 6x30 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 259 6x30 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 157 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM4 S 161 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 S 161 4x38 G.HN Q 28 G.HN.52
Polar H8 Y 324 8x54 G.H5 I 352 G.H5.23
Hydrophobic H8 Y 324 8x54 G.H5 I 352 G.H5.23
Hydrophobic TM3 V 150 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 154 34x51 G.S2 F 192 G.S2.08
Polar ICL2 S 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 I 251 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 153 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 157 34x54 G.S1 I 34 G.S1.02
Hydrophobic TM3 A 149 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 I 352 G.H5.23
Polar TM2 E 83 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 E 83 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 E 83 2x37 G.H5 Y 351 G.H5.22
Hydrophobic H8 Y 324 8x54 G.H5 G 353 G.H5.24