Gz - LPA5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term T 325 - G.H3 N 258 G.H3.16
Hydrophobic ICL3 T 224 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 T 224 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 L 127 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 127 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 I 34 G.S1.02
Hydrophobic ICL2 P 126 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 L 218 5x65 G.H5 L 349 G.H5.20
Ionic ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Aromatic ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 Y 297 7x53 G.H5 L 354 G.H5.25
Van-der-waals TM7 Y 297 7x53 G.H5 L 354 G.H5.25
Polar H8 G 303 8x49 G.H5 C 355 G.H5.26
Hydrophobic H8 G 303 8x49 G.H5 C 355 G.H5.26
Van-der-waals H8 G 303 8x49 G.H5 C 355 G.H5.26
Hydrophobic TM2 M 61 2x43 G.H5 L 354 G.H5.25
Polar H8 E 302 8x48 G.H5 L 354 G.H5.25
Van-der-waals H8 E 302 8x48 G.H5 L 354 G.H5.25
Polar ICL2 R 133 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 R 133 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 133 34x57 G.H5 N 348 G.H5.19
Polar TM3 A 122 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 348 G.H5.19
Hydrophobic H8 A 301 8x47 G.H5 L 354 G.H5.25
Van-der-waals H8 A 301 8x47 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 235 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM2 V 57 2x39 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 T 341 G.H5.12
Polar TM6 S 226 6x27 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 228 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 126 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM4 R 134 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 R 134 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 I 123 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 349 G.H5.20
Polar ICL2 R 130 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 R 130 34x54 G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 R 130 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic TM3 I 123 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM6 T 232 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 T 232 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 127 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 R 128 34x52 G.S3 L 195 G.S3.01
Hydrophobic TM6 R 228 6x29 G.H5 K 350 G.H5.21
Van-der-waals TM6 R 228 6x29 G.H5 K 350 G.H5.21
Hydrophobic ICL2 L 127 34x51 G.H5 V 340 G.H5.11
Polar H8 G 303 8x49 G.H5 L 354 G.H5.25
Hydrophobic H8 G 303 8x49 G.H5 L 354 G.H5.25
Van-der-waals H8 G 303 8x49 G.H5 L 354 G.H5.25
Hydrophobic H8 E 302 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 E 302 8x48 G.H5 C 355 G.H5.26
Van-der-waals ICL2 L 127 34x51 G.H5 T 341 G.H5.12
Polar ICL3 T 224 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 T 224 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 H 131 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 122 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM3 R 119 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 I 352 G.H5.23