G12 - BLT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 126 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 A 58 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 58 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 225 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 225 6x36 G.H5 M 379 G.H5.24
Ionic TM7 D 294 7x59 G.H5 K 376 G.H5.21
Polar TM7 D 294 7x59 G.H5 K 376 G.H5.21
Hydrophobic TM3 V 123 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 127 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 127 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 126 34x50 G.H5 K 367 G.H5.12
Ionic ICL2 R 133 34x57 G.H5 E 373 G.H5.18
Polar ICL2 R 133 34x57 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 133 34x57 G.H5 E 373 G.H5.18
Hydrophobic ICL2 F 127 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 F 127 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 R 131 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 131 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 W 213 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 W 213 - G.H5 L 371 G.H5.16
Polar TM3 R 119 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM2 A 57 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 127 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM3 A 122 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM7 T 291 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 T 291 7x56 G.H5 M 379 G.H5.24
Polar TM7 A 292 7x57 G.H5 M 379 G.H5.24
Hydrophobic TM7 A 292 7x57 G.H5 M 379 G.H5.24
Van-der-waals TM7 A 292 7x57 G.H5 M 379 G.H5.24
Hydrophobic TM7 D 294 7x59 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 128 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 128 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 V 222 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM7 A 292 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 213 - G.H5 L 375 G.H5.20
Ionic ICL1 R 52 12x51 G.H5 E 373 G.H5.18
Polar ICL1 R 52 12x51 G.H5 E 373 G.H5.18
Hydrophobic ICL1 R 52 12x51 G.H5 E 373 G.H5.18
Van-der-waals ICL1 R 52 12x51 G.H5 E 373 G.H5.18
Hydrophobic TM2 P 55 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 P 55 2x37 G.H5 D 377 G.H5.22
Polar ICL2 R 131 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 R 131 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 R 131 34x55 G.HN R 52 G.HN.52
Hydrophobic TM6 V 222 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 222 6x33 G.H5 M 379 G.H5.24
Polar TM4 S 134 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 L 295 7x60 G.H5 L 380 G.H5.25
Polar ICL2 R 131 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 131 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 131 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 Y 288 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 127 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 127 34x51 G.H5 I 370 G.H5.15
Polar ICL2 P 126 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 127 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 127 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 H 218 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 H 218 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM5 L 208 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 208 5x65 G.H5 L 375 G.H5.20
Polar TM7 T 291 7x56 G.H5 Q 381 G.H5.26
Van-der-waals TM7 T 291 7x56 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 127 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 127 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 V 222 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL3 W 213 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 W 213 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Ionic ICL2 R 133 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 133 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 133 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 133 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM6 G 219 6x30 G.H5 L 375 G.H5.20
Polar ICL1 R 52 12x51 G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL1 R 52 12x51 G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL1 R 52 12x51 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 R 221 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 129 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 A 129 34x53 G.H5 N 374 G.H5.19
Polar TM3 A 122 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 374 G.H5.19
Polar ICL3 W 213 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 W 213 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 W 213 - G.H5 D 368 G.H5.13
Hydrophobic ICL1 R 52 12x51 G.h3s5 V 289 G.h3s5.03
Van-der-waals ICL1 R 52 12x51 G.h3s5 V 289 G.h3s5.03
Hydrophobic TM3 V 123 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 123 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM7 A 292 7x57 G.H5 Q 381 G.H5.26
Hydrophobic TM2 V 61 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM2 A 57 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 A 57 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 V 123 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 123 3x54 G.H5 L 375 G.H5.20