Go - MT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term Q 358 - G.s4h3 D 238 G.s4h3.11
Polar TM3 R 138 3x50 G.H5 G 352 G.H5.24
Ionic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 249 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM5 A 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 A 230 5x68 G.H5 D 341 G.H5.13
Ionic C-term D 360 - G.H2 R 209 G.H2.04
Polar C-term D 360 - G.H2 R 209 G.H2.04
Hydrophobic C-term D 360 - G.H2 R 209 G.H2.04
Van-der-waals C-term D 360 - G.H2 R 209 G.H2.04
Hydrophobic TM5 A 230 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 223 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Ionic TM5 R 231 5x69 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 231 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 231 5x69 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 231 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 253 6x37 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 253 6x37 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 220 5x58 G.H5 L 353 G.H5.25
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Polar TM3 Y 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 Y 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 K 233 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 233 5x71 G.H5 D 337 G.H5.09
Polar C-term A 361 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 362 - G.S1 L 39 G.S1.07
Polar ICL3 K 235 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 K 235 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 K 235 - G.S6 I 319 G.S6.01
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 227 5x65 G.H5 I 344 G.H5.16
Ionic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 226 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 234 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 A 234 5x72 G.S6 Y 320 G.S6.02
Ionic C-term H 357 - G.H2 E 208 G.H2.03
Polar C-term H 357 - G.H2 E 208 G.H2.03
Hydrophobic TM5 A 234 5x72 G.H5 A 338 G.H5.10
Polar C-term L 362 - G.H1 K 46 G.H1.01
Hydrophobic C-term L 362 - G.H1 K 46 G.H1.01
Van-der-waals C-term L 362 - G.H1 K 46 G.H1.01
Hydrophobic C-term L 362 - G.s3h2 G 203 G.s3h2.01
Van-der-waals C-term L 362 - G.s3h2 G 203 G.s3h2.01
Hydrophobic C-term L 362 - G.H3 L 250 G.H3.08
Aromatic ICL3 K 235 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 235 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 235 - G.S6 Y 320 G.S6.02
Hydrophobic C-term L 362 - G.S3 V 202 G.S3.08
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 N 312 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 312 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 A 230 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 A 230 5x68 G.H5 I 344 G.H5.16
Hydrophobic C-term L 362 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term L 362 - G.s1h1 G 40 G.s1h1.01
Hydrophobic C-term L 362 - G.H2 W 212 G.H2.07
Hydrophobic TM5 A 234 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term L 362 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 362 - G.H2 R 209 G.H2.04
Hydrophobic TM5 A 234 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 M 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 253 6x37 G.H5 L 353 G.H5.25