G12 - NMU2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 80 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM6 I 258 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 I 258 6x25 G.S6 F 347 G.S6.02
Polar TM6 N 255 6x22 G.H4 Q 328 G.H4.08
Van-der-waals TM6 N 255 6x22 G.H4 Q 328 G.H4.08
Ionic TM6 R 263 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 263 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 263 6x30 G.H5 D 368 G.H5.13
Hydrophobic ICL2 F 152 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM3 I 148 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 144 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 249 5x71 G.H5 H 364 G.H5.09
Polar H8 R 333 8x49 G.H5 K 376 G.H5.21
Hydrophobic H8 R 333 8x49 G.H5 K 376 G.H5.21
Van-der-waals H8 R 333 8x49 G.H5 K 376 G.H5.21
Polar TM6 N 255 6x22 G.S6 H 349 G.S6.04
Hydrophobic TM6 N 255 6x22 G.S6 H 349 G.S6.04
Van-der-waals TM6 N 255 6x22 G.S6 H 349 G.S6.04
Ionic TM6 R 260 6x27 G.H5 D 368 G.H5.13
Polar TM6 R 260 6x27 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 260 6x27 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 260 6x27 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 243 5x65 G.H5 L 371 G.H5.16
Polar TM3 R 144 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 258 6x25 G.H5 F 361 G.H5.06
Van-der-waals TM6 I 258 6x25 G.H5 F 361 G.H5.06
Polar TM3 R 144 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM6 A 256 6x23 G.S6 H 349 G.S6.04
Polar TM3 A 147 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 273 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 256 6x23 G.S6 H 348 G.S6.03
Hydrophobic ICL2 F 152 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 P 151 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 Q 259 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 259 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 242 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 242 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM6 A 256 6x23 G.H5 F 361 G.H5.06
Hydrophobic TM2 L 84 2x43 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 270 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 148 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 L 371 G.H5.16
Polar H8 R 332 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 332 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 332 8x48 G.H5 Q 381 G.H5.26
Van-der-waals TM4 R 161 4x40 G.HN R 52 G.HN.52
Hydrophobic TM2 T 80 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 152 34x51 G.H5 K 367 G.H5.12
Polar ICL2 P 151 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 151 34x50 G.H5 N 374 G.H5.19
Hydrophobic H8 S 331 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 243 5x65 G.H5 L 375 G.H5.20
Hydrophobic H8 R 333 8x49 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 151 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 266 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 266 6x33 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 152 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 152 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 M 269 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 269 6x36 G.H5 M 379 G.H5.24
Polar H8 R 333 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 152 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 152 34x51 G.S1 V 58 G.S1.02
Hydrophobic H8 F 334 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM2 N 81 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 N 81 2x40 G.H5 M 379 G.H5.24
Ionic ICL2 K 155 34x54 G.H5 E 373 G.H5.18
Polar ICL2 K 155 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 K 155 34x54 G.H5 E 373 G.H5.18
Polar TM6 N 257 6x24 G.S6 H 348 G.S6.03
Hydrophobic TM6 N 257 6x24 G.S6 H 348 G.S6.03
Van-der-waals TM6 N 257 6x24 G.S6 H 348 G.S6.03
Hydrophobic TM6 P 261 6x28 G.H5 Q 372 G.H5.17
Van-der-waals TM6 P 261 6x28 G.H5 Q 372 G.H5.17
Hydrophobic TM6 M 269 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 269 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 148 3x54 G.H5 L 380 G.H5.25
Hydrophobic TM7 Y 327 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 327 7x53 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 266 6x33 G.H5 L 375 G.H5.20
Ionic H8 R 333 8x49 G.H5 D 377 G.H5.22
Polar H8 R 333 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 333 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 333 8x49 G.H5 D 377 G.H5.22
Polar H8 S 331 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 331 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 152 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 R 263 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 263 6x30 G.H5 L 371 G.H5.16
Polar TM6 N 255 6x22 G.S6 F 350 G.S6.05
Hydrophobic TM6 N 255 6x22 G.S6 F 350 G.S6.05
Van-der-waals TM6 N 255 6x22 G.S6 F 350 G.S6.05
Hydrophobic TM3 I 148 3x54 G.H5 I 378 G.H5.23
Aromatic ICL2 F 152 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 152 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 152 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 151 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 151 34x50 G.H5 K 367 G.H5.12
Hydrophobic C-term F 371 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 K 155 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM3 A 147 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL1 M 76 12x50 G.H5 M 379 G.H5.24
Van-der-waals ICL1 M 76 12x50 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 156 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 156 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 P 261 6x28 G.h4s6 P 345 G.h4s6.20