G12 - oxoglutarate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 139 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 M 139 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 L 235 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 235 6x29 G.H5 Q 372 G.H5.17
Polar H8 N 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 308 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM1 Y 58 1x57 G.H5 L 380 G.H5.25
Van-der-waals TM1 Y 58 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM4 K 146 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 K 146 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Ionic TM6 K 236 6x30 G.H5 D 368 G.H5.13
Polar TM6 K 236 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 K 236 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 K 236 6x30 G.H5 D 368 G.H5.13
Polar TM7 V 305 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 235 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 235 6x29 G.H5 L 375 G.H5.20
Hydrophobic ICL3 L 229 - G.H5 H 364 G.H5.09
Polar ICL2 H 145 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 145 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 H 145 34x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 F 127 3x46 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 139 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 M 139 34x51 G.H5 V 366 G.H5.11
Polar TM3 V 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 M 139 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 139 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 S 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 M 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 F 142 34x54 G.hns1 R 56 G.hns1.03
Polar H8 S 306 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 306 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 306 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 235 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 235 6x29 G.H5 M 379 G.H5.24
Polar H8 S 306 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 306 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 142 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 A 239 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 239 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM7 Y 302 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 225 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 134 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 134 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM2 T 69 2x40 G.H5 L 380 G.H5.25
Polar TM3 I 136 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM2 S 68 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 236 6x30 G.H5 L 371 G.H5.16
Hydrophobic ICL2 M 139 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 K 236 6x30 G.H5 L 375 G.H5.20
Ionic TM2 K 66 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 66 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 66 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 66 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL3 Q 230 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 Q 230 - G.S6 F 347 G.S6.02
Van-der-waals ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 138 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 235 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 K 238 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM7 V 305 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 235 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 L 235 6x29 G.H5 Q 381 G.H5.26
Polar H8 D 307 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 307 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 307 8x48 G.H5 Q 381 G.H5.26
Polar TM2 S 68 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 68 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 142 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 F 142 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 L 242 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 135 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL3 Q 230 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 230 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 M 139 34x51 G.H5 F 363 G.H5.08
Polar ICL3 Q 230 - G.H5 Q 372 G.H5.17
Polar H8 N 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 308 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 139 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 139 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM3 F 130 3x49 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 239 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 239 6x33 G.H5 M 379 G.H5.24