G12 - P2Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 139 34x51 G.S1 V 58 G.S1.02
Polar ICL2 G 145 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 T 232 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 232 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM4 R 146 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 R 146 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 135 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 142 34x54 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 139 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 V 135 3x54 G.H5 M 379 G.H5.24
Polar TM3 G 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 139 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 139 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 142 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 A 229 5x69 G.H5 D 368 G.H5.13
Van-der-waals TM5 A 229 5x69 G.H5 D 368 G.H5.13
Hydrophobic ICL3 T 232 - G.S6 F 347 G.S6.02
Polar TM6 S 243 6x34 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 243 6x34 G.H5 Q 381 G.H5.26
Polar ICL2 S 141 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 141 34x53 G.H5 N 374 G.H5.19
Polar TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 K 242 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 242 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 225 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 131 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 G 134 3x53 G.H5 I 378 G.H5.23
Ionic TM5 R 224 5x64 G.H5 D 368 G.H5.13
Hydrophobic H8 G 310 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 139 34x51 G.H5 K 367 G.H5.12
Polar ICL2 R 143 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 143 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM6 S 243 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 S 243 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 247 6x38 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 247 6x38 G.H5 M 379 G.H5.24
Hydrophobic ICL3 G 231 - G.H5 F 361 G.H5.06
Polar ICL3 Y 230 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 Y 230 - G.H5 D 368 G.H5.13
Polar TM6 A 239 6x30 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 239 6x30 G.H5 Q 381 G.H5.26
Van-der-waals TM6 A 239 6x30 G.H5 Q 381 G.H5.26
Van-der-waals ICL3 Y 230 - G.S6 F 347 G.S6.02
Polar ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 138 34x50 G.H5 L 371 G.H5.16
Hydrophobic H8 Q 311 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 311 8x48 G.H5 Q 381 G.H5.26
Aromatic ICL3 Y 230 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 Y 230 - G.H5 H 364 G.H5.09
Hydrophobic TM5 M 221 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 M 221 5x61 G.H5 M 379 G.H5.24
Hydrophobic TM2 M 72 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 72 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 243 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 240 6x31 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 139 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM7 A 309 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 A 309 7x56 G.H5 L 380 G.H5.25
Ionic H8 R 312 8x49 G.H5 D 377 G.H5.22
Polar H8 R 312 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM3 H 130 3x49 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 Y 230 - G.H5 F 361 G.H5.06