Gs - IP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 Y 127 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 127 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 127 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM1 L 38 1x57 G.H5 L 393 G.H5.25
Ionic ICL2 D 131 34x57 G.HN K 34 G.HN.51
Polar ICL2 D 131 34x57 G.HN K 34 G.HN.51
Hydrophobic ICL2 D 131 34x57 G.HN K 34 G.HN.51
Van-der-waals ICL2 D 131 34x57 G.HN K 34 G.HN.51
Hydrophobic ICL3 G 222 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 222 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM3 A 120 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 120 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Polar H8 K 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 297 8x48 G.H5 E 392 G.H5.24
Polar TM4 R 134 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 134 4x40 G.HN Q 31 G.HN.48
Hydrophobic ICL2 A 128 34x54 G.S1 H 41 G.S1.02
Aromatic TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 121 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 213 5x66 G.H5 D 381 G.H5.13
Van-der-waals TM5 M 213 5x66 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 220 5x73 G.S6 H 362 G.S6.04
Hydrophobic TM5 M 213 5x66 G.H5 L 388 G.H5.20
Hydrophobic H8 R 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 124 34x50 G.H5 Q 384 G.H5.16
Polar ICL2 L 130 34x56 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 H 220 5x73 G.S6 Y 360 G.S6.02
Polar TM5 Q 217 5x70 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 217 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 217 5x70 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 210 5x63 G.H5 L 388 G.H5.20
Hydrophobic H8 V 299 8x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 125 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL3 L 224 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 L 224 - G.H4 D 343 G.H4.13
Hydrophobic H8 R 302 8x53 G.H5 L 394 G.H5.26
Van-der-waals H8 R 302 8x53 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 121 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM7 I 293 7x54 G.H5 L 393 G.H5.25
Hydrophobic H8 A 298 8x49 G.H5 L 394 G.H5.26
Van-der-waals H8 A 298 8x49 G.H5 L 394 G.H5.26
Ionic TM5 H 220 5x73 G.H5 D 378 G.H5.10
Polar TM5 H 220 5x73 G.S6 P 361 G.S6.03
Hydrophobic ICL2 A 128 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 A 128 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Aromatic ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Ionic ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Polar ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 F 49 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 F 49 2x39 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 124 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 124 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 M 213 5x66 G.H5 R 385 G.H5.17
Polar ICL3 S 223 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 S 223 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 S 223 - G.hgh4 D 323 G.hgh4.13
Polar TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 125 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 H 237 6x33 G.H5 E 392 G.H5.24
Polar H8 A 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 A 298 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 A 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM2 A 50 2x40 G.H5 L 393 G.H5.25
Hydrophobic H8 R 296 8x47 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 213 5x66 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 213 5x66 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 227 6x23 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM6 R 227 6x23 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 Y 125 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 125 34x51 G.H5 I 383 G.H5.15
Polar TM5 R 219 5x72 G.hgh4 T 325 G.hgh4.15
Aromatic ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 T 230 6x26 G.h4s6 G 355 G.h4s6.11
Polar TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Ionic TM6 E 234 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 234 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 234 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 121 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 121 3x54 G.H5 L 388 G.H5.20
Polar TM1 R 41 1x60 G.H5 L 393 G.H5.25
Van-der-waals TM1 R 41 1x60 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 124 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 124 34x50 G.H5 R 380 G.H5.12
Polar TM3 A 120 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 120 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Q 129 34x55 G.hns1 A 39 G.hns1.03
Polar TM6 H 237 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 237 6x33 G.H5 L 388 G.H5.20
Polar H8 R 296 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 296 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 R 296 8x47 G.H5 Y 391 G.H5.23
Polar TM3 E 116 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 116 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 116 3x49 G.H5 Y 391 G.H5.23