Gt1 - TAS2R42 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R42 81.7
Gαt1 87.4
Gβ1 92.1
Gγ2 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM3 K 110 3x53 G.H5 D 346 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 346 G.H5.22
Hydrophobic TM3 K 110 3x53 G.H5 D 346 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 346 G.H5.22
Polar ICL3 R 222 - G.S6 S 317 G.S6.03
Van-der-waals ICL3 R 222 - G.S6 S 317 G.S6.03
Hydrophobic TM6 A 228 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 A 228 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM6 H 229 6x31 G.H5 K 341 G.H5.17
Hydrophobic TM3 I 111 3x54 G.H5 I 340 G.H5.16
Hydrophobic TM5 H 210 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 H 210 5x68 G.H5 I 340 G.H5.16
Polar ICL3 R 222 - G.S6 I 315 G.S6.01
Hydrophobic ICL3 R 222 - G.S6 I 315 G.S6.01
Van-der-waals ICL3 R 222 - G.S6 I 315 G.S6.01
Hydrophobic TM3 K 110 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL3 L 219 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 L 219 - G.S6 Y 316 G.S6.02
Hydrophobic TM6 H 229 6x31 G.H5 L 344 G.H5.20
Polar TM6 S 225 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM6 S 225 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM6 S 225 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM7 G 287 7x56 G.H5 G 348 G.H5.24
Hydrophobic TM6 S 225 6x27 G.h4s6 E 314 G.h4s6.12
Polar TM3 Y 107 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 347 G.H5.23
Polar TM3 K 110 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 343 G.H5.19
Polar TM6 S 225 6x27 G.H5 D 337 G.H5.13
Van-der-waals TM6 S 225 6x27 G.H5 D 337 G.H5.13
Hydrophobic TM3 Y 107 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM6 M 235 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL3 L 219 - G.S6 H 318 G.S6.04
Van-der-waals ICL3 L 219 - G.S6 H 318 G.S6.04
Hydrophobic TM5 H 210 5x68 G.H5 T 336 G.H5.12
Polar TM6 R 231 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM6 R 231 6x33 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 231 6x33 G.H5 F 350 G.H5.26
Polar H8 N 288 8x47 G.H5 G 348 G.H5.24
Hydrophobic H8 N 288 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 N 288 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM3 F 106 3x49 G.H5 C 347 G.H5.23
Hydrophobic TM5 S 218 5x76 G.H5 F 330 G.H5.06
Van-der-waals TM5 S 218 5x76 G.H5 F 330 G.H5.06
Hydrophobic TM6 A 232 6x34 G.H5 L 344 G.H5.20
Van-der-waals TM6 A 232 6x34 G.H5 L 344 G.H5.20
Polar H8 S 289 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 S 289 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 S 289 8x48 G.H5 F 350 G.H5.26
Hydrophobic ICL2 H 113 34x44 G.H5 T 336 G.H5.12
Hydrophobic ICL3 L 219 - G.H5 A 334 G.H5.10
Hydrophobic TM3 I 111 3x54 G.H5 L 344 G.H5.20
Hydrophobic ICL3 R 222 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 R 222 - G.S6 Y 316 G.S6.02
Polar H8 S 289 8x48 G.H5 G 348 G.H5.24
Van-der-waals H8 S 289 8x48 G.H5 G 348 G.H5.24
Hydrophobic TM6 H 229 6x31 G.H5 I 340 G.H5.16
Van-der-waals TM6 H 229 6x31 G.H5 I 340 G.H5.16
Polar ICL2 W 124 34x55 G.hns1 R 28 G.hns1.03
Aromatic ICL2 W 124 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 W 124 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 W 124 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 I 111 3x54 G.H5 N 343 G.H5.19
Hydrophobic TM6 A 228 6x30 G.H5 K 341 G.H5.17
Hydrophobic TM3 I 111 3x54 G.H5 C 347 G.H5.23
Van-der-waals TM3 I 111 3x54 G.H5 C 347 G.H5.23
Hydrophobic TM5 L 207 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM3 I 111 3x54 G.H5 L 349 G.H5.25
Ionic ICL3 R 222 - G.h4s6 E 314 G.h4s6.12
Polar ICL3 R 222 - G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL3 R 222 - G.h4s6 E 314 G.h4s6.12
Van-der-waals ICL3 R 222 - G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 F 239 6x41 G.H5 L 349 G.H5.25
Hydrophobic TM5 L 214 5x72 G.H5 D 337 G.H5.13
Van-der-waals TM5 L 214 5x72 G.H5 D 337 G.H5.13
Hydrophobic ICL2 L 120 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 L 120 34x51 G.s2s3 D 189 G.s2s3.02
Ionic TM6 H 229 6x31 G.H5 D 337 G.H5.13
Polar TM6 H 229 6x31 G.H5 D 337 G.H5.13
Van-der-waals TM6 H 229 6x31 G.H5 D 337 G.H5.13
Ionic TM5 H 210 5x68 G.H5 D 337 G.H5.13
Polar TM5 H 210 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 H 210 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 H 210 5x68 G.H5 D 337 G.H5.13
Polar TM5 S 218 5x76 G.S6 H 318 G.S6.04
Hydrophobic TM5 S 218 5x76 G.S6 H 318 G.S6.04
Hydrophobic ICL3 L 219 - G.H5 D 333 G.H5.09