Gi2 - VPAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 319 5x61 G.H5 L 349 G.H5.20
Hydrophobic C-term V 454 - G.H2 R 206 G.H2.01
Van-der-waals C-term V 454 - G.H2 R 206 G.H2.01
Polar C-term T 438 - G.H3 K 258 G.H3.16
Hydrophobic C-term T 438 - G.H3 K 258 G.H3.16
Van-der-waals C-term T 438 - G.H3 K 258 G.H3.16
Hydrophobic ICL2 F 248 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 248 - G.S3 L 195 G.S3.01
Hydrophobic TM2 R 174 2x46 G.H5 C 352 G.H5.23
Hydrophobic TM5 I 318 5x60 G.H5 I 345 G.H5.16
Hydrophobic ICL2 S 247 - G.H5 I 345 G.H5.16
Hydrophobic TM5 L 319 5x61 G.H5 L 354 G.H5.25
Hydrophobic C-term V 457 - G.H2 R 209 G.H2.04
Van-der-waals C-term V 457 - G.H2 R 209 G.H2.04
Hydrophobic TM3 L 244 3x58 G.H5 N 348 G.H5.19
Polar C-term S 455 - G.H2 R 209 G.H2.04
Van-der-waals C-term S 455 - G.H2 R 209 G.H2.04
Ionic TM4 R 252 4x40 G.HN E 28 G.HN.52
Polar TM4 R 252 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 252 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 252 4x40 G.HN E 28 G.HN.52
Hydrophobic TM5 K 322 5x64 G.H5 L 349 G.H5.20
Polar ICL3 K 330 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 K 330 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 K 330 - G.h4s6 K 315 G.h4s6.08
Hydrophobic TM4 R 252 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 252 4x40 G.HN R 24 G.HN.48
Hydrophobic TM3 L 244 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 244 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 346 6x45 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 346 6x45 G.H5 L 354 G.H5.25
Hydrophobic C-term L 456 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term L 456 - G.s4h3 E 237 G.s4h3.10
Polar C-term Q 451 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term Q 451 - G.s4h3 D 238 G.s4h3.11
Polar TM2 R 174 2x46 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 174 2x46 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 174 2x46 G.H5 D 351 G.H5.22
Hydrophobic TM5 K 322 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 322 5x64 G.H5 I 345 G.H5.16
Polar TM4 S 250 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 S 250 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 S 250 4x38 G.hns1 R 32 G.hns1.03
Polar C-term A 452 - G.H2 R 209 G.H2.04
Hydrophobic C-term A 452 - G.H2 R 209 G.H2.04
Van-der-waals C-term A 452 - G.H2 R 209 G.H2.04
Hydrophobic TM3 L 244 3x58 G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 248 - G.H5 V 340 G.H5.11
Van-der-waals C-term V 457 - G.s1h1 G 40 G.s1h1.01
Hydrophobic C-term V 457 - G.s3h2 G 203 G.s3h2.01
Van-der-waals C-term V 457 - G.s3h2 G 203 G.s3h2.01
Hydrophobic C-term V 457 - G.H1 K 46 G.H1.01
Van-der-waals C-term V 457 - G.H1 K 46 G.H1.01
Polar TM6 S 342 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 342 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 342 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 240 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 L 240 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 F 248 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 248 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 248 - G.S1 V 34 G.S1.02
Hydrophobic C-term L 456 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term L 456 - G.s3h2 G 204 G.s3h2.02
Hydrophobic TM5 L 323 5x65 G.H5 F 355 G.H5.26
Van-der-waals TM5 L 323 5x65 G.H5 F 355 G.H5.26
Polar TM3 L 243 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 243 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 243 3x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 S 247 - G.H5 I 344 G.H5.15
Ionic C-term E 453 - G.H2 K 210 G.H2.05
Polar C-term E 453 - G.H2 K 210 G.H2.05
Hydrophobic C-term E 453 - G.H2 K 210 G.H2.05
Van-der-waals C-term E 453 - G.H2 K 210 G.H2.05
Hydrophobic TM3 L 240 3x54 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 240 3x54 G.H5 C 352 G.H5.23
Ionic TM5 K 322 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 322 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 322 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 322 5x64 G.H5 D 342 G.H5.13
Aromatic TM6 R 338 6x37 G.H5 F 355 G.H5.26
Hydrophobic C-term V 457 - G.H3 L 250 G.H3.08
Van-der-waals C-term V 457 - G.H3 L 250 G.H3.08
Polar C-term E 453 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 456 - G.H2 R 206 G.H2.01
Polar C-term V 457 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic ICL2 F 248 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 248 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 F 248 - G.H5 F 337 G.H5.08
Hydrophobic C-term V 457 - G.S1 L 39 G.S1.07
Van-der-waals C-term V 457 - G.S1 L 39 G.S1.07
Polar C-term V 457 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term V 457 - G.s3h2 G 204 G.s3h2.02