G12 - XCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 223 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 T 223 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 131 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 131 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 135 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 135 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 135 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 135 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 138 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 138 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM2 I 70 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 70 2x43 G.H5 L 380 G.H5.25
Polar TM4 T 142 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 T 142 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 T 142 4x38 G.HN R 52 G.HN.52
Hydrophobic C-term F 332 - G.H3 I 280 G.H3.12
Polar ICL3 R 216 - G.H5 D 368 G.H5.13
Hydrophobic TM3 R 127 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 I 378 G.H5.23
Polar ICL2 P 134 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 134 34x50 G.H5 N 374 G.H5.19
Polar TM3 V 132 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 132 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 220 6x30 G.H5 L 375 G.H5.20
Ionic H8 K 293 8x49 G.H5 D 377 G.H5.22
Polar H8 K 293 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 293 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 293 8x49 G.H5 L 380 G.H5.25
Ionic ICL1 E 63 12x51 G.hns1 R 55 G.hns1.02
Polar ICL1 E 63 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 E 63 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 138 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 138 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic H8 G 291 8x47 G.H5 L 380 G.H5.25
Polar ICL3 S 217 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 S 217 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 S 217 - G.H5 Q 372 G.H5.17
Polar H8 V 292 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 V 292 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 L 135 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 V 140 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 140 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 T 223 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 223 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 135 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 T 211 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 220 6x30 G.H5 Q 372 G.H5.17
Hydrophobic C-term F 332 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term F 332 - G.H2 W 238 G.H2.07
Hydrophobic TM7 Y 287 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM2 T 66 2x39 G.H5 I 378 G.H5.23
Polar C-term Y 333 - G.H2 S 233 G.H2.02
Hydrophobic C-term A 330 - G.H2 F 239 G.H2.08
Polar TM3 S 130 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 S 215 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM2 N 67 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 67 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 135 34x51 G.H5 I 370 G.H5.15
Aromatic C-term F 332 - G.H2 F 239 G.H2.08
Hydrophobic C-term F 332 - G.H2 F 239 G.H2.08
Van-der-waals C-term F 332 - G.H2 F 239 G.H2.08
Hydrophobic TM6 I 227 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 I 227 6x37 G.H5 I 378 G.H5.23
Polar TM5 S 215 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 215 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 215 5x68 G.H5 D 368 G.H5.13
Hydrophobic C-term F 332 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 332 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 P 134 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 134 34x50 G.H5 K 367 G.H5.12
Hydrophobic C-term Y 333 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Y 333 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 L 138 34x54 G.hns1 R 56 G.hns1.03
Polar ICL2 T 137 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 137 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 I 227 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 134 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 212 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 212 5x65 G.H5 L 375 G.H5.20
Polar H8 K 293 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 293 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 293 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 138 34x54 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 138 34x54 G.S1 V 58 G.S1.02
Hydrophobic H8 V 292 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 131 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 139 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 139 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 S 130 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 130 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 134 34x50 G.H5 L 371 G.H5.16
Polar C-term Y 333 - G.H2 R 232 G.H2.01
Hydrophobic C-term Y 333 - G.H2 R 232 G.H2.01
Van-der-waals C-term Y 333 - G.H2 R 232 G.H2.01