Refined structure (6WWZ) of Go - CCR6

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.3%), 144 from model (40.7%)
Residue sidechains - 200 from structure (56.5%), 154 from model (43.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure Structure
G.HN 10 R G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 AF2 AF2
G.H1 53 M G.H1.08 AF2 AF2
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 Structure Structure
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure AF2
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure AF2
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure AF2
G.hgh4 291 Y G.hgh4.05 Structure AF2
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 310 from structure (89.9%), 35 from model (10.1%)
Residue sidechains - 306 from structure (88.7%), 39 from model (11.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 M - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 F - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 V - AF2 AF2
N-term 12 F - AF2 AF2
N-term 13 D - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 E - AF2 AF2
N-term 17 D - AF2 AF2
N-term 18 Y - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 V - AF2 AF2
N-term 23 N - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 Y - AF2 AF2
N-term 27 Y - Structure Structure
N-term 28 S - Structure Structure
N-term 29 V - Structure Structure
N-term 30 D - Structure AF2
N-term 31 S - Structure Structure
N-term 32 E - Structure Structure
N-term 33 M - Structure AF2
N-term 34 L - Structure Structure
N-term 35 L - Structure Structure
N-term 36 C - Structure Structure
N-term 37 S - Structure Structure
N-term 38 L - Structure Structure
TM1 39 Q 1.25x25 Structure Structure
TM1 40 E 1.26x26 Structure Structure
TM1 41 V 1.27x27 Structure Structure
TM1 42 R 1.28x28 Structure Structure
TM1 43 Q 1.29x29 Structure Structure
TM1 44 F 1.30x30 Structure Structure
TM1 45 S 1.31x31 Structure Structure
TM1 46 R 1.32x32 Structure Structure
TM1 47 L 1.33x33 Structure Structure
TM1 48 F 1.34x34 Structure Structure
TM1 49 V 1.35x35 Structure Structure
TM1 50 P 1.36x36 Structure Structure
TM1 51 I 1.37x37 Structure Structure
TM1 52 A 1.38x38 Structure Structure
TM1 53 Y 1.39x39 Structure Structure
TM1 54 S 1.40x40 Structure Structure
TM1 55 L 1.41x41 Structure Structure
TM1 56 I 1.42x42 Structure Structure
TM1 57 C 1.43x43 Structure Structure
TM1 58 V 1.44x44 Structure Structure
TM1 59 F 1.45x45 Structure Structure
TM1 60 G 1.46x46 Structure Structure
TM1 61 L 1.47x47 Structure Structure
TM1 62 L 1.48x48 Structure Structure
TM1 63 G 1.49x49 Structure Structure
TM1 64 N 1.50x50 Structure Structure
TM1 65 I 1.51x51 Structure Structure
TM1 66 L 1.52x52 Structure Structure
TM1 67 V 1.53x53 Structure Structure
TM1 68 V 1.54x54 Structure Structure
TM1 69 I 1.55x55 Structure Structure
TM1 70 T 1.56x56 Structure Structure
TM1 71 F 1.57x57 Structure Structure
TM1 72 A 1.58x58 Structure Structure
TM1 73 F 1.59x59 Structure Structure
TM1 74 Y 1.60x60 Structure Structure
ICL1 75 K 12.48x48 Structure Structure
ICL1 76 K 12.49x49 Structure AF2
ICL1 77 A 12.50x50 Structure Structure
ICL1 78 R 12.51x51 Structure Structure
TM2 79 S 2.37x37 Structure Structure
TM2 80 M 2.38x38 Structure Structure
TM2 81 T 2.39x39 Structure Structure
TM2 82 D 2.40x40 Structure Structure
TM2 83 V 2.41x41 Structure Structure
TM2 84 Y 2.42x42 Structure Structure
TM2 85 L 2.43x43 Structure Structure
TM2 86 L 2.44x44 Structure Structure
TM2 87 N 2.45x45 Structure Structure
TM2 88 M 2.46x46 Structure Structure
TM2 89 A 2.47x47 Structure Structure
TM2 90 I 2.48x48 Structure Structure
TM2 91 A 2.49x49 Structure Structure
TM2 92 D 2.50x50 Structure Structure
TM2 93 I 2.51x51 Structure Structure
TM2 94 L 2.52x52 Structure Structure
TM2 95 F 2.53x53 Structure Structure
TM2 96 V 2.54x54 Structure Structure
TM2 97 L 2.55x55 Structure Structure
TM2 98 T 2.56x56 Structure Structure
TM2 99 L 2.57x57 Structure Structure
TM2 100 P 2.58x58 Structure Structure
TM2 101 F 2.59x59 Structure Structure
TM2 102 W 2.60x60 Structure Structure
TM2 103 A 2.61x61 Structure Structure
TM2 104 V 2.62x62 Structure Structure
TM2 105 S 2.63x63 Structure Structure
TM2 106 H 2.64x64 Structure Structure
TM2 107 A 2.65x65 Structure Structure
TM2 108 T 2.66x66 Structure Structure
TM2 109 G 2.67x67 Structure Structure
ECL1 110 A 23.49x49 Structure Structure
ECL1 111 W 23.50x50 Structure Structure
ECL1 112 V 23.51x51 Structure Structure
ECL1 113 F 23.52x52 Structure Structure
TM3 114 S 3.21x21 Structure Structure
TM3 115 N 3.22x22 Structure Structure
TM3 116 A 3.23x23 Structure Structure
TM3 117 T 3.24x24 Structure Structure
TM3 118 C 3.25x25 Structure Structure
TM3 119 K 3.26x26 Structure Structure
TM3 120 L 3.27x27 Structure Structure
TM3 121 L 3.28x28 Structure Structure
TM3 122 K 3.29x29 Structure Structure
TM3 123 G 3.30x30 Structure Structure
TM3 124 I 3.31x31 Structure Structure
TM3 125 Y 3.32x32 Structure Structure
TM3 126 A 3.33x33 Structure Structure
TM3 127 I 3.34x34 Structure Structure
TM3 128 N 3.35x35 Structure Structure
TM3 129 F 3.36x36 Structure Structure
TM3 130 N 3.37x37 Structure Structure
TM3 131 C 3.38x38 Structure Structure
TM3 132 G 3.39x39 Structure Structure
TM3 133 M 3.40x40 Structure Structure
TM3 134 L 3.41x41 Structure Structure
TM3 135 L 3.42x42 Structure Structure
TM3 136 L 3.43x43 Structure Structure
TM3 137 T 3.44x44 Structure Structure
TM3 138 C 3.45x45 Structure Structure
TM3 139 I 3.46x46 Structure Structure
TM3 140 S 3.47x47 Structure Structure
TM3 141 M 3.48x48 Structure Structure
TM3 142 D 3.49x49 Structure Structure
TM3 143 R 3.50x50 Structure Structure
TM3 144 Y 3.51x51 Structure Structure
TM3 145 I 3.52x52 Structure Structure
TM3 146 A 3.53x53 Structure Structure
TM3 147 I 3.54x54 Structure Structure
TM3 148 V 3.55x55 Structure Structure
TM3 149 Q 3.56x56 Structure Structure
ICL2 150 A 34.50x50 Structure Structure
ICL2 151 T 34.51x51 Structure Structure
ICL2 152 K 34.52x52 Structure Structure
ICL2 153 S 34.53x53 Structure Structure
ICL2 154 F 34.54x54 Structure Structure
ICL2 155 R 34.55x55 Structure Structure
ICL2 156 L 34.56x56 Structure Structure
ICL2 157 R - Structure Structure
ICL2 158 S - Structure Structure
ICL2 159 R - Structure Structure
TM4 160 T 4.38x38 Structure Structure
TM4 161 L 4.39x39 Structure Structure
TM4 162 P 4.40x40 Structure Structure
TM4 163 R 4.41x41 Structure Structure
TM4 164 S 4.42x42 Structure Structure
TM4 165 K 4.43x43 Structure Structure
TM4 166 I 4.44x44 Structure Structure
TM4 167 I 4.45x45 Structure Structure
TM4 168 C 4.46x46 Structure Structure
TM4 169 L 4.47x47 Structure Structure
TM4 170 V 4.48x48 Structure Structure
TM4 171 V 4.49x49 Structure Structure
TM4 172 W 4.50x50 Structure Structure
TM4 173 G 4.51x51 Structure Structure
TM4 174 L 4.52x52 Structure Structure
TM4 175 S 4.53x53 Structure Structure
TM4 176 V 4.54x54 Structure Structure
TM4 177 I 4.55x55 Structure Structure
TM4 178 I 4.56x56 Structure Structure
TM4 179 S 4.57x57 Structure Structure
TM4 180 S 4.58x59 Structure Structure
TM4 181 S 4.59x60 Structure Structure
TM4 182 T 4.60x61 Structure Structure
TM4 183 F 4.61x62 Structure Structure
TM4 184 V 4.62x63 Structure Structure
TM4 185 F 4.63x64 Structure Structure
TM4 186 N 4.64x65 Structure Structure
ECL2 187 Q - Structure Structure
ECL2 188 K - Structure Structure
ECL2 189 Y - Structure Structure
ECL2 190 N - Structure Structure
ECL2 191 T - Structure Structure
ECL2 192 Q - Structure Structure
ECL2 193 G - Structure Structure
ECL2 194 S - Structure Structure
ECL2 195 D - Structure Structure
ECL2 196 V - Structure Structure
ECL2 197 C 45.50x50 Structure Structure
ECL2 198 E 45.51x51 Structure Structure
ECL2 199 P 45.52x52 Structure Structure
ECL2 200 K - Structure Structure
ECL2 201 Y - Structure Structure
ECL2 202 Q - Structure Structure
ECL2 203 T - Structure Structure
ECL2 204 V - Structure Structure
ECL2 205 S - Structure Structure
ECL2 206 E - Structure Structure
TM5 207 P 5.31x32 Structure Structure
TM5 208 I 5.32x33 Structure Structure
TM5 209 R 5.33x34 Structure Structure
TM5 210 W 5.34x35 Structure Structure
TM5 211 K 5.35x36 Structure Structure
TM5 212 L 5.36x37 Structure Structure
TM5 213 L 5.37x38 Structure Structure
TM5 214 M 5.38x39 Structure Structure
TM5 215 L 5.39x40 Structure Structure
TM5 216 G 5.40x41 Structure Structure
TM5 217 L 5.41x42 Structure Structure
TM5 218 E 5.42x43 Structure Structure
TM5 219 L 5.43x44 Structure Structure
TM5 220 L 5.44x45 Structure Structure
TM5 221 F 5.45x46 Structure Structure
TM5 222 G 5.46x461 Structure Structure
TM5 223 F 5.47x47 Structure Structure
TM5 224 F 5.48x48 Structure Structure
TM5 225 I 5.49x49 Structure Structure
TM5 226 P 5.50x50 Structure Structure
TM5 227 L 5.51x51 Structure Structure
TM5 228 M 5.52x52 Structure Structure
TM5 229 F 5.53x53 Structure Structure
TM5 230 M 5.54x54 Structure Structure
TM5 231 I 5.55x55 Structure Structure
TM5 232 F 5.56x56 Structure Structure
TM5 233 C 5.57x57 Structure Structure
TM5 234 Y 5.58x58 Structure Structure
TM5 235 T 5.59x59 Structure Structure
TM5 236 F 5.60x60 Structure Structure
TM5 237 I 5.61x61 Structure Structure
TM5 238 V 5.62x62 Structure Structure
TM5 239 K 5.63x63 Structure Structure
TM5 240 T 5.64x64 Structure Structure
TM5 241 L 5.65x65 Structure Structure
TM5 242 V 5.66x66 Structure Structure
TM5 243 Q 5.67x67 Structure Structure
TM5 244 A 5.68x68 Structure Structure
ICL3 245 Q - Structure Structure
ICL3 246 N - Structure Structure
TM6 247 S 6.28x28 Structure Structure
TM6 248 K 6.29x29 Structure Structure
TM6 249 R 6.30x30 Structure Structure
TM6 250 H 6.31x31 Structure Structure
TM6 251 K 6.32x32 Structure Structure
TM6 252 A 6.33x33 Structure Structure
TM6 253 I 6.34x34 Structure Structure
TM6 254 R 6.35x35 Structure Structure
TM6 255 V 6.36x36 Structure Structure
TM6 256 I 6.37x37 Structure Structure
TM6 257 I 6.38x38 Structure Structure
TM6 258 A 6.39x39 Structure Structure
TM6 259 V 6.40x40 Structure Structure
TM6 260 V 6.41x41 Structure Structure
TM6 261 L 6.42x42 Structure Structure
TM6 262 V 6.43x43 Structure Structure
TM6 263 F 6.44x44 Structure Structure
TM6 264 L 6.45x45 Structure Structure
TM6 265 A 6.46x46 Structure Structure
TM6 266 C 6.47x47 Structure Structure
TM6 267 Q 6.48x48 Structure Structure
TM6 268 I 6.49x49 Structure Structure
TM6 269 P 6.50x50 Structure Structure
TM6 270 H 6.51x51 Structure Structure
TM6 271 N 6.52x52 Structure Structure
TM6 272 M 6.53x53 Structure Structure
TM6 273 V 6.54x54 Structure Structure
TM6 274 L 6.55x55 Structure Structure
TM6 275 L 6.56x56 Structure Structure
TM6 276 V 6.57x57 Structure Structure
TM6 277 T 6.58x58 Structure Structure
TM6 278 A 6.59x59 Structure Structure
TM6 279 A 6.60x60 Structure Structure
TM6 280 N 6.61x61 Structure Structure
TM6 281 L 6.62x62 Structure Structure
TM6 282 G 6.63x63 Structure Structure
TM6 283 K 6.64x64 Structure Structure
TM6 284 M 6.65x65 Structure Structure
ECL3 285 N - Structure Structure
ECL3 286 R - Structure Structure
TM7 287 S 7.24x23 Structure Structure
TM7 288 C 7.25x24 Structure Structure
TM7 289 Q 7.26x25 Structure Structure
TM7 290 S 7.27x26 Structure Structure
TM7 291 E 7.28x27 Structure Structure
TM7 292 K 7.29x28 Structure Structure
TM7 293 L 7.30x29 Structure Structure
TM7 294 I 7.31x30 Structure Structure
TM7 295 G 7.32x31 Structure Structure
TM7 296 Y 7.33x32 Structure Structure
TM7 297 T 7.34x33 Structure Structure
TM7 298 K 7.35x34 Structure Structure
TM7 299 T 7.36x35 Structure Structure
TM7 300 V 7.37x36 Structure Structure
TM7 301 T 7.38x37 Structure Structure
TM7 302 E 7.39x38 Structure Structure
TM7 303 V 7.40x39 Structure Structure
TM7 304 L 7.41x40 Structure Structure
TM7 305 A 7.42x41 Structure Structure
TM7 306 F 7.43x42 Structure Structure
TM7 307 L 7.44x43 Structure Structure
TM7 308 H 7.45x45 Structure Structure
TM7 309 C 7.46x46 Structure Structure
TM7 310 C 7.47x47 Structure Structure
TM7 311 L 7.48x48 Structure Structure
TM7 312 N 7.49x49 Structure Structure
TM7 313 P 7.50x50 Structure Structure
TM7 314 V 7.51x51 Structure Structure
TM7 315 L 7.52x52 Structure Structure
TM7 316 Y 7.53x53 Structure Structure
TM7 317 A 7.54x54 Structure Structure
TM7 318 F 7.55x55 Structure Structure
TM7 319 I 7.56x56 Structure Structure
H8 320 G 8.47x47 Structure Structure
H8 321 Q 8.48x48 Structure Structure
H8 322 K 8.49x49 Structure Structure
H8 323 F 8.50x50 Structure Structure
H8 324 R 8.51x51 Structure Structure
H8 325 N 8.52x52 Structure Structure
H8 326 Y 8.53x53 Structure Structure
H8 327 F 8.54x54 Structure Structure
H8 328 L 8.55x55 Structure Structure
H8 329 K 8.56x56 Structure Structure
H8 330 I 8.57x57 Structure Structure
H8 331 L 8.58x58 Structure Structure
H8 332 K 8.59x59 Structure Structure
H8 333 D 8.60x60 Structure AF2
H8 334 L 8.61x61 Structure Structure
H8 335 W 8.62x62 Structure Structure
C-term 336 C - Structure Structure
C-term 337 V - AF2 AF2
C-term 338 R - AF2 AF2
C-term 339 R - AF2 AF2
C-term 340 K - AF2 AF2
C-term 341 Y - AF2 AF2
C-term 342 K - AF2 AF2
C-term 343 S - AF2 AF2
C-term 344 S - AF2 AF2
C-term 345 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL3 N 246 - G.H5 A 345 G.H5.17
Polar ICL3 Q 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 245 - G.H5 D 341 G.H5.13
Aromatic TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Polar H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Polar TM3 A 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 146 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 Q 245 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Q 245 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 143 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 248 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 248 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM7 I 319 7x56 G.H5 Y 354 G.H5.26
Hydrophobic TM2 T 81 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 T 81 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL2 R 155 34x55 G.S3 L 195 G.S3.01
Polar TM6 K 248 6x29 G.H5 A 345 G.H5.17
Hydrophobic TM6 I 256 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 T 81 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 147 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 147 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 143 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 A 150 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 154 34x54 G.S1 D 33 G.S1.01
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 150 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 154 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM3 A 146 3x53 G.H5 C 351 G.H5.23
Polar H8 G 320 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 320 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 252 6x33 G.H5 L 353 G.H5.25
Polar TM6 S 247 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 R 157 - G.hns1 K 32 G.hns1.03
Hydrophobic TM6 A 252 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 157 - G.hns1 A 31 G.hns1.02