Refined structure (7CZ5) of Gs - GHRH receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 228 from structure (57.9%), 166 from model (42.1%)
Residue sidechains - 220 from structure (55.8%), 174 from model (44.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (64.8%), 146 from model (35.2%)
Residue sidechains - 268 from structure (64.6%), 147 from model (35.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 R - AF2 AF2
N-term 4 R - AF2 AF2
N-term 5 M - AF2 AF2
N-term 6 W - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 H - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 F - AF2 AF2
N-term 12 C - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 H - AF2 AF2
N-term 24 M - AF2 AF2
N-term 25 H - AF2 AF2
N-term 26 P - AF2 AF2
N-term 27 E - AF2 AF2
N-term 28 C - AF2 AF2
N-term 29 D - AF2 AF2
N-term 30 F - AF2 AF2
N-term 31 I - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 Q - AF2 AF2
N-term 34 L - AF2 AF2
N-term 35 R - AF2 AF2
N-term 36 E - AF2 AF2
N-term 37 D - AF2 AF2
N-term 38 E - AF2 AF2
N-term 39 S - AF2 AF2
N-term 40 A - AF2 AF2
N-term 41 C - AF2 AF2
N-term 42 L - AF2 AF2
N-term 43 Q - AF2 AF2
N-term 44 A - AF2 AF2
N-term 45 A - AF2 AF2
N-term 46 E - AF2 AF2
N-term 47 E - AF2 AF2
N-term 48 M - AF2 AF2
N-term 49 P - AF2 AF2
N-term 50 N - AF2 AF2
N-term 51 T - AF2 AF2
N-term 52 T - AF2 AF2
N-term 53 L - AF2 AF2
N-term 54 G - AF2 AF2
N-term 55 C - AF2 AF2
N-term 56 P - AF2 AF2
N-term 57 A - AF2 AF2
N-term 58 T - AF2 AF2
N-term 59 W - AF2 AF2
N-term 60 D - AF2 AF2
N-term 61 G - AF2 AF2
N-term 62 L - AF2 AF2
N-term 63 L - AF2 AF2
N-term 64 C - AF2 AF2
N-term 65 W - AF2 AF2
N-term 66 P - AF2 AF2
N-term 67 T - AF2 AF2
N-term 68 A - AF2 AF2
N-term 69 G - AF2 AF2
N-term 70 S - AF2 AF2
N-term 71 G - AF2 AF2
N-term 72 E - AF2 AF2
N-term 73 W - AF2 AF2
N-term 74 V - AF2 AF2
N-term 75 T - AF2 AF2
N-term 76 L - AF2 AF2
N-term 77 P - AF2 AF2
N-term 78 C - AF2 AF2
N-term 79 P - AF2 AF2
N-term 80 D - AF2 AF2
N-term 81 F - AF2 AF2
N-term 82 F - AF2 AF2
N-term 83 S - AF2 AF2
N-term 84 H - AF2 AF2
N-term 85 F - AF2 AF2
N-term 86 S - AF2 AF2
N-term 87 S - AF2 AF2
N-term 88 E - AF2 AF2
N-term 89 S - AF2 AF2
N-term 90 G - AF2 AF2
N-term 91 A - AF2 AF2
N-term 92 V - AF2 AF2
N-term 93 K - AF2 AF2
N-term 94 R - AF2 AF2
N-term 95 D - AF2 AF2
N-term 96 C - AF2 AF2
N-term 97 T - AF2 AF2
N-term 98 I - AF2 AF2
N-term 99 T - AF2 AF2
N-term 100 G - AF2 AF2
N-term 101 W - AF2 AF2
N-term 102 S - AF2 AF2
N-term 103 E - AF2 AF2
N-term 104 P - AF2 AF2
N-term 105 F - AF2 AF2
N-term 106 P - AF2 AF2
N-term 107 P - AF2 AF2
N-term 108 Y - AF2 AF2
N-term 109 P - AF2 AF2
N-term 110 V - AF2 AF2
N-term 111 A - AF2 AF2
N-term 112 C - AF2 AF2
N-term 113 P - AF2 AF2
N-term 114 V - AF2 AF2
N-term 115 P - AF2 AF2
TM1 116 L 1.26x26 AF2 AF2
TM1 117 E 1.27x27 AF2 AF2
TM1 118 L 1.28x28 AF2 AF2
TM1 119 L 1.29x29 Structure Structure
TM1 120 A 1.30x30 Structure Structure
TM1 121 E 1.31x31 Structure Structure
TM1 122 E 1.32x32 Structure Structure
TM1 123 E 1.33x33 Structure Structure
TM1 124 S 1.34x34 Structure Structure
TM1 125 Y 1.35x35 Structure Structure
TM1 126 F 1.36x36 Structure Structure
TM1 127 S 1.37x37 Structure Structure
TM1 128 T 1.38x38 Structure Structure
TM1 129 V 1.39x39 Structure Structure
TM1 130 K 1.40x40 Structure Structure
TM1 131 I 1.41x41 Structure Structure
TM1 132 I 1.42x42 Structure Structure
TM1 133 Y 1.43x43 Structure Structure
TM1 134 T 1.44x44 Structure Structure
TM1 135 V 1.45x45 Structure Structure
TM1 136 G 1.46x46 Structure Structure
TM1 137 H 1.47x47 Structure Structure
TM1 138 S 1.48x48 Structure Structure
TM1 139 I 1.49x49 Structure Structure
TM1 140 S 1.50x50 Structure Structure
TM1 141 I 1.51x51 Structure Structure
TM1 142 V 1.52x52 Structure Structure
TM1 143 A 1.53x53 Structure Structure
TM1 144 L 1.54x54 Structure Structure
TM1 145 F 1.55x55 Structure Structure
TM1 146 V 1.56x56 Structure Structure
TM1 147 A 1.57x57 Structure Structure
TM1 148 I 1.58x58 Structure Structure
TM1 149 T 1.59x59 Structure Structure
TM1 150 I 1.60x60 Structure Structure
TM1 151 L 1.61x61 Structure Structure
TM1 152 V 1.62x62 Structure Structure
TM1 153 A 1.63x63 Structure Structure
TM1 154 L 1.64x64 Structure Structure
ICL1 155 R 12.48x48 Structure Structure
ICL1 156 R 12.49x49 Structure Structure
ICL1 157 L 12.50x50 Structure Structure
ICL1 158 H 12.51x51 Structure Structure
TM2 159 C 2.44x44 Structure Structure
TM2 160 P 2.45x45 Structure Structure
TM2 161 R 2.46x46 Structure Structure
TM2 162 N 2.47x47 Structure Structure
TM2 163 Y 2.48x48 Structure Structure
TM2 164 V 2.49x49 Structure Structure
TM2 165 H 2.50x50 Structure Structure
TM2 166 T 2.51x51 Structure Structure
TM2 167 Q 2.52x52 Structure Structure
TM2 168 L 2.53x53 Structure Structure
TM2 169 F 2.54x54 Structure Structure
TM2 170 T 2.55x55 Structure Structure
TM2 171 T 2.56x56 Structure Structure
TM2 172 F 2.57x57 Structure Structure
TM2 173 I 2.58x58 Structure Structure
TM2 174 L 2.59x59 Structure Structure
TM2 175 K 2.60x60 Structure Structure
TM2 176 A 2.61x61 Structure Structure
TM2 177 G 2.62x62 Structure Structure
TM2 178 A 2.63x63 Structure Structure
TM2 179 V 2.64x64 Structure Structure
TM2 180 F 2.65x65 Structure Structure
TM2 181 L 2.66x66 Structure Structure
TM2 182 K 2.67x67 Structure Structure
TM2 183 D 2.68x68 Structure Structure
TM2 184 A 2.69x69 Structure Structure
TM2 185 A 2.70x70 Structure Structure
TM2 186 L 2.71x71 Structure Structure
TM2 187 F 2.72x72 Structure Structure
ECL1 188 H - Structure Structure
ECL1 189 S - Structure Structure
ECL1 190 D - Structure Structure
ECL1 191 D - Structure Structure
ECL1 192 T - Structure Structure
ECL1 193 D - Structure Structure
ECL1 194 H - Structure Structure
ECL1 195 C - Structure Structure
ECL1 196 S - Structure Structure
ECL1 197 F - Structure Structure
ECL1 198 S - Structure Structure
TM3 199 T 3.26x26 Structure Structure
TM3 200 V 3.27x27 Structure Structure
TM3 201 L 3.28x28 Structure Structure
TM3 202 C 3.29x29 Structure Structure
TM3 203 K 3.30x30 Structure Structure
TM3 204 V 3.31x31 Structure Structure
TM3 205 S 3.32x32 Structure Structure
TM3 206 V 3.33x33 Structure Structure
TM3 207 A 3.34x34 Structure Structure
TM3 208 A 3.35x35 Structure Structure
TM3 209 S 3.36x36 Structure Structure
TM3 210 H 3.37x37 Structure Structure
TM3 211 F 3.38x38 Structure Structure
TM3 212 A 3.39x39 Structure Structure
TM3 213 T 3.40x40 Structure Structure
TM3 214 M 3.41x41 Structure Structure
TM3 215 T 3.42x42 Structure Structure
TM3 216 N 3.43x43 Structure Structure
TM3 217 F 3.44x44 Structure Structure
TM3 218 S 3.45x45 Structure Structure
TM3 219 W 3.46x46 Structure Structure
TM3 220 L 3.47x47 Structure Structure
TM3 221 L 3.48x48 Structure Structure
TM3 222 A 3.49x49 Structure Structure
TM3 223 E 3.50x50 Structure Structure
TM3 224 A 3.51x51 Structure Structure
TM3 225 V 3.52x52 Structure Structure
TM3 226 Y 3.53x53 Structure Structure
TM3 227 L 3.54x54 Structure Structure
TM3 228 N 3.55x55 Structure Structure
TM3 229 C 3.56x56 Structure Structure
TM3 230 L 3.57x57 Structure Structure
TM3 231 L 3.58x58 Structure Structure
TM3 232 A 3.59x59 Structure Structure
TM3 233 S 3.60x60 Structure Structure
ICL2 234 T - Structure Structure
ICL2 235 S - Structure Structure
ICL2 236 P - Structure Structure
ICL2 237 S - Structure Structure
ICL2 238 S - Structure Structure
TM4 239 R 4.39x40 Structure Structure
TM4 240 R 4.40x41 Structure Structure
TM4 241 A 4.41x42 Structure Structure
TM4 242 F 4.42x43 Structure Structure
TM4 243 W 4.43x44 Structure Structure
TM4 244 W 4.44x45 Structure Structure
TM4 245 L 4.45x46 Structure Structure
TM4 246 V 4.46x47 Structure Structure
TM4 247 L 4.47x48 Structure Structure
TM4 248 A 4.48x49 Structure Structure
TM4 249 G 4.49x491 Structure Structure
TM4 250 W 4.50x50 Structure Structure
TM4 251 G 4.51x51 Structure Structure
TM4 252 L 4.52x52 Structure Structure
TM4 253 P 4.53x53 Structure Structure
TM4 254 V 4.54x54 Structure Structure
TM4 255 L 4.55x55 Structure Structure
TM4 256 F 4.56x56 Structure Structure
TM4 257 T 4.57x57 Structure Structure
TM4 258 G 4.58x58 Structure Structure
TM4 259 T 4.59x59 Structure Structure
TM4 260 W 4.60x60 Structure Structure
TM4 261 V 4.61x61 Structure Structure
TM4 262 S 4.62x62 Structure Structure
TM4 263 C 4.63x63 Structure Structure
TM4 264 K 4.64x64 Structure Structure
TM4 265 L 4.65x65 Structure Structure
TM4 266 A 4.66x66 Structure Structure
TM4 267 F 4.67x67 Structure Structure
TM4 268 E 4.68x68 Structure Structure
ECL2 269 D - Structure Structure
ECL2 270 I - Structure Structure
ECL2 271 A - Structure Structure
ECL2 272 C 45.50x50 Structure Structure
ECL2 273 W 45.51x51 Structure Structure
ECL2 274 D 45.52x52 Structure Structure
ECL2 275 L - Structure Structure
ECL2 276 D - Structure Structure
ECL2 277 D - Structure Structure
ECL2 278 T - Structure Structure
ECL2 279 S - Structure Structure
ECL2 280 P - Structure Structure
ECL2 281 Y - Structure Structure
TM5 282 W 5.36x37 Structure Structure
TM5 283 W 5.37x38 Structure Structure
TM5 284 I 5.38x381 Structure Structure
TM5 285 I 5.39x39 Structure Structure
TM5 286 K 5.40x40 Structure Structure
TM5 287 G 5.41x41 Structure Structure
TM5 288 P 5.42x42 Structure Structure
TM5 289 I 5.43x43 Structure Structure
TM5 290 V 5.44x44 Structure Structure
TM5 291 L 5.45x45 Structure Structure
TM5 292 S 5.46x46 Structure Structure
TM5 293 V 5.47x47 Structure Structure
TM5 294 G 5.48x48 Structure Structure
TM5 295 V 5.49x49 Structure Structure
TM5 296 N 5.50x50 Structure Structure
TM5 297 F 5.51x51 Structure Structure
TM5 298 G 5.52x52 Structure Structure
TM5 299 L 5.53x53 Structure Structure
TM5 300 F 5.54x54 Structure Structure
TM5 301 L 5.55x55 Structure Structure
TM5 302 N 5.56x56 Structure Structure
TM5 303 I 5.57x57 Structure Structure
TM5 304 I 5.58x58 Structure Structure
TM5 305 R 5.59x59 Structure Structure
TM5 306 I 5.60x60 Structure Structure
TM5 307 L 5.61x61 Structure Structure
TM5 308 V 5.62x62 Structure Structure
TM5 309 R 5.63x63 Structure Structure
TM5 310 K 5.64x64 Structure Structure
TM5 311 L 5.65x65 Structure Structure
ICL3 312 E - Structure Structure
ICL3 313 P - AF2 AF2
ICL3 314 A - AF2 AF2
ICL3 315 Q - AF2 AF2
ICL3 316 G - AF2 AF2
ICL3 317 S - AF2 AF2
ICL3 318 L - AF2 AF2
TM6 319 H 6.30x30 AF2 AF2
TM6 320 T 6.31x31 Structure Structure
TM6 321 Q 6.32x32 Structure Structure
TM6 322 S 6.33x33 Structure Structure
TM6 323 Q 6.34x34 Structure Structure
TM6 324 Y 6.35x35 Structure Structure
TM6 325 W 6.36x36 Structure Structure
TM6 326 R 6.37x37 Structure Structure
TM6 327 L 6.38x38 Structure Structure
TM6 328 S 6.39x39 Structure Structure
TM6 329 K 6.40x40 Structure Structure
TM6 330 S 6.41x41 Structure Structure
TM6 331 T 6.42x42 Structure Structure
TM6 332 L 6.43x43 Structure Structure
TM6 333 F 6.44x44 Structure Structure
TM6 334 L 6.45x45 Structure Structure
TM6 335 I 6.46x46 Structure Structure
TM6 336 P 6.47x47 Structure Structure
TM6 337 L 6.48x48 Structure Structure
TM6 338 F 6.49x49 Structure Structure
TM6 339 G 6.50x50 Structure Structure
TM6 340 I 6.51x51 Structure Structure
TM6 341 H 6.52x52 Structure Structure
TM6 342 Y 6.53x53 Structure Structure
TM6 343 I 6.54x54 Structure Structure
TM6 344 I 6.55x55 Structure Structure
TM6 345 F 6.56x56 Structure Structure
TM6 346 N 6.57x57 Structure Structure
TM6 347 F 6.58x58 Structure Structure
TM6 348 L 6.59x59 Structure Structure
ECL3 349 P - Structure Structure
ECL3 350 D - Structure Structure
ECL3 351 N - Structure AF2
ECL3 352 A - Structure Structure
TM7 353 G 7.34x33 Structure Structure
TM7 354 L 7.35x34 Structure Structure
TM7 355 G 7.36x35 Structure Structure
TM7 356 I 7.37x36 Structure Structure
TM7 357 R 7.38x37 Structure Structure
TM7 358 L 7.39x38 Structure Structure
TM7 359 P 7.40x39 Structure Structure
TM7 360 L 7.41x40 Structure Structure
TM7 361 E 7.42x41 Structure Structure
TM7 362 L 7.43x42 Structure Structure
TM7 363 G 7.44x43 Structure Structure
TM7 364 L 7.45x44 Structure Structure
TM7 365 G 7.46x45 Structure Structure
TM7 366 S 7.47x46 Structure Structure
TM7 367 F 7.48x47 Structure Structure
TM7 368 Q 7.49x49 Structure Structure
TM7 369 G 7.50x50 Structure Structure
TM7 370 F 7.51x51 Structure Structure
TM7 371 I 7.52x52 Structure Structure
TM7 372 V 7.53x53 Structure Structure
TM7 373 A 7.54x54 Structure Structure
TM7 374 I 7.55x55 Structure Structure
TM7 375 L 7.56x56 Structure Structure
TM7 376 Y 7.57x57 Structure Structure
TM7 377 C 7.58x58 Structure Structure
TM7 378 F 7.59x59 Structure Structure
TM7 379 L 7.60x60 Structure Structure
H8 380 N 8.47x47 Structure Structure
H8 381 Q 8.48x48 Structure Structure
H8 382 E 8.49x49 Structure Structure
H8 383 V 8.50x50 Structure Structure
H8 384 R 8.51x51 Structure Structure
H8 385 T 8.52x52 Structure Structure
H8 386 E 8.53x53 Structure Structure
H8 387 I 8.54x54 Structure Structure
H8 388 S 8.55x55 Structure Structure
H8 389 R 8.56x56 Structure Structure
H8 390 K 8.57x57 Structure Structure
H8 391 W 8.58x58 Structure Structure
H8 392 H 8.59x59 Structure Structure
H8 393 G 8.60x60 Structure Structure
H8 394 H 8.61x61 Structure Structure
H8 395 D 8.62x62 AF2 AF2
H8 396 P 8.63x63 AF2 AF2
H8 397 E 8.64x64 AF2 AF2
H8 398 L 8.65x65 AF2 AF2
H8 399 L 8.66x66 AF2 AF2
H8 400 P 8.67x67 AF2 AF2
H8 401 A 8.68x68 AF2 AF2
H8 402 W 8.69x69 AF2 AF2
H8 403 R 8.70x70 AF2 AF2
H8 404 T 8.71x71 AF2 AF2
H8 405 R 8.72x72 AF2 AF2
C-term 406 A - AF2 AF2
C-term 407 K - AF2 AF2
C-term 408 W - AF2 AF2
C-term 409 T - AF2 AF2
C-term 410 T - AF2 AF2
C-term 411 P - AF2 AF2
C-term 412 S - AF2 AF2
C-term 413 R - AF2 AF2
C-term 414 S - AF2 AF2
C-term 415 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Polar H8 N 380 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 380 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 380 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 237 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 R 326 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 311 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Polar TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 R 385 G.H5.17
Polar TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 307 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Aromatic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Polar TM6 R 326 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 326 6x37 G.H5 E 392 G.H5.24
Polar TM3 L 231 3x58 G.H5 R 380 G.H5.12
Hydrophobic ICL3 Q 315 - G.h4s6 Y 358 G.h4s6.20
Polar TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 307 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 310 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 T 234 - G.H5 F 376 G.H5.08
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Polar TM3 S 233 3x60 G.H5 R 380 G.H5.12
Van-der-waals TM3 S 233 3x60 G.H5 R 380 G.H5.12
Polar H8 Q 381 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 381 8x48 G.H5 E 392 G.H5.24
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 307 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 T 234 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 334 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 310 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 236 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 234 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 234 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 S 235 - G.S3 V 217 G.S3.01
Ionic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 310 5x64 G.H5 D 381 G.H5.13
Polar TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 393 G.H5.25
Polar TM6 R 326 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 326 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 326 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 227 3x54 G.H5 L 393 G.H5.25
Van-der-waals ICL3 A 314 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 Q 315 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 315 - G.H4 L 346 G.H4.16
Polar ICL3 Q 315 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 315 - G.S6 C 359 G.S6.01