Refined structure (7UM5) of Go - 5-HT5A receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 214 from structure (60.5%), 140 from model (39.5%)
Residue sidechains - 197 from structure (55.6%), 157 from model (44.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure AF2
G.HN 10 R G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure AF2
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure AF2
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure AF2
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure AF2
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure AF2
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure AF2
G.HG 281 K G.HG.12 Structure AF2
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure AF2
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 267 from structure (79.5%), 69 from model (20.5%)
Residue sidechains - 235 from structure (69.9%), 101 from model (30.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 F - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 H - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 K - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 D - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 R - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 S - AF2 AF2
N-term 33 S - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 L - AF2 AF2
TM1 36 L 1.28x28 AF2 AF2
TM1 37 S 1.29x29 AF2 AF2
TM1 38 V 1.30x30 AF2 AF2
TM1 39 F 1.31x31 AF2 AF2
TM1 40 G 1.32x32 AF2 AF2
TM1 41 V 1.33x33 Structure Structure
TM1 42 L 1.34x34 Structure AF2
TM1 43 I 1.35x35 Structure Structure
TM1 44 L 1.36x36 Structure Structure
TM1 45 T 1.37x37 Structure Structure
TM1 46 L 1.38x38 Structure Structure
TM1 47 L 1.39x39 Structure Structure
TM1 48 G 1.40x40 Structure Structure
TM1 49 F 1.41x41 Structure AF2
TM1 50 L 1.42x42 Structure Structure
TM1 51 V 1.43x43 Structure Structure
TM1 52 A 1.44x44 Structure Structure
TM1 53 A 1.45x45 Structure Structure
TM1 54 T 1.46x46 Structure Structure
TM1 55 F 1.47x47 Structure Structure
TM1 56 A 1.48x48 Structure Structure
TM1 57 W 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 L 1.51x51 Structure Structure
TM1 60 L 1.52x52 Structure Structure
TM1 61 V 1.53x53 Structure Structure
TM1 62 L 1.54x54 Structure Structure
TM1 63 A 1.55x55 Structure Structure
TM1 64 T 1.56x56 Structure Structure
TM1 65 I 1.57x57 Structure Structure
TM1 66 L 1.58x58 Structure Structure
TM1 67 R 1.59x59 Structure AF2
TM1 68 V 1.60x60 Structure Structure
ICL1 69 R 12.48x48 Structure AF2
ICL1 70 T 12.49x49 Structure AF2
ICL1 71 F 12.50x50 Structure Structure
ICL1 72 H 12.51x51 Structure Structure
TM2 73 R 2.37x37 Structure AF2
TM2 74 V 2.38x38 Structure Structure
TM2 75 P 2.39x39 Structure Structure
TM2 76 H 2.40x40 Structure Structure
TM2 77 N 2.41x41 Structure Structure
TM2 78 L 2.42x42 Structure Structure
TM2 79 V 2.43x43 Structure Structure
TM2 80 A 2.44x44 Structure Structure
TM2 81 S 2.45x45 Structure Structure
TM2 82 M 2.46x46 Structure Structure
TM2 83 A 2.47x47 Structure Structure
TM2 84 V 2.48x48 Structure Structure
TM2 85 S 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure Structure
TM2 87 V 2.51x51 Structure Structure
TM2 88 L 2.52x52 Structure Structure
TM2 89 V 2.53x53 Structure Structure
TM2 90 A 2.54x54 Structure Structure
TM2 91 A 2.55x55 Structure Structure
TM2 92 L 2.56x551 Structure Structure
TM2 93 V 2.57x56 Structure Structure
TM2 94 M 2.58x57 Structure Structure
TM2 95 P 2.59x58 Structure Structure
TM2 96 L 2.60x59 Structure Structure
TM2 97 S 2.61x60 Structure Structure
TM2 98 L 2.62x61 Structure Structure
TM2 99 V 2.63x62 Structure Structure
TM2 100 H 2.64x63 Structure Structure
TM2 101 E 2.65x64 Structure Structure
TM2 102 L 2.66x65 Structure AF2
TM2 103 S 2.67x66 Structure Structure
TM2 104 G 2.68x67 Structure Structure
ECL1 105 R - Structure AF2
ECL1 106 R 23.49x49 Structure AF2
ECL1 107 W 23.50x50 Structure Structure
ECL1 108 Q 23.51x51 Structure Structure
ECL1 109 L 23.52x52 Structure Structure
TM3 110 G 3.21x21 Structure Structure
TM3 111 R 3.22x22 Structure Structure
TM3 112 R 3.23x23 Structure AF2
TM3 113 L 3.24x24 Structure Structure
TM3 114 C 3.25x25 Structure Structure
TM3 115 Q 3.26x26 Structure Structure
TM3 116 L 3.27x27 Structure Structure
TM3 117 W 3.28x28 Structure Structure
TM3 118 I 3.29x29 Structure Structure
TM3 119 A 3.30x30 Structure Structure
TM3 120 C 3.31x31 Structure Structure
TM3 121 D 3.32x32 Structure Structure
TM3 122 V 3.33x33 Structure Structure
TM3 123 L 3.34x34 Structure Structure
TM3 124 C 3.35x35 Structure Structure
TM3 125 C 3.36x36 Structure Structure
TM3 126 T 3.37x37 Structure Structure
TM3 127 A 3.38x38 Structure Structure
TM3 128 S 3.39x39 Structure Structure
TM3 129 I 3.40x40 Structure Structure
TM3 130 W 3.41x41 Structure Structure
TM3 131 N 3.42x42 Structure Structure
TM3 132 V 3.43x43 Structure Structure
TM3 133 T 3.44x44 Structure Structure
TM3 134 A 3.45x45 Structure Structure
TM3 135 I 3.46x46 Structure Structure
TM3 136 A 3.47x47 Structure Structure
TM3 137 L 3.48x48 Structure Structure
TM3 138 D 3.49x49 Structure Structure
TM3 139 R 3.50x50 Structure Structure
TM3 140 Y 3.51x51 Structure Structure
TM3 141 W 3.52x52 Structure Structure
TM3 142 S 3.53x53 Structure Structure
TM3 143 I 3.54x54 Structure Structure
TM3 144 T 3.55x55 Structure Structure
TM3 145 R 3.56x56 Structure Structure
ICL2 146 H 34.50x50 Structure AF2
ICL2 147 M 34.51x51 Structure Structure
ICL2 148 E 34.52x52 Structure AF2
ICL2 149 Y 34.53x53 Structure Structure
ICL2 150 T 34.54x54 Structure Structure
TM4 151 L 4.35x35 Structure Structure
TM4 152 R 4.36x36 Structure AF2
TM4 153 T 4.37x37 Structure Structure
TM4 154 R 4.38x38 Structure Structure
TM4 155 K 4.39x39 Structure AF2
TM4 156 C 4.40x40 Structure Structure
TM4 157 V 4.41x41 Structure Structure
TM4 158 S 4.42x42 Structure Structure
TM4 159 N 4.43x43 Structure Structure
TM4 160 V 4.44x44 Structure Structure
TM4 161 M 4.45x45 Structure Structure
TM4 162 I 4.46x46 Structure Structure
TM4 163 A 4.47x47 Structure Structure
TM4 164 L 4.48x48 Structure Structure
TM4 165 T 4.49x49 Structure Structure
TM4 166 W 4.50x50 Structure Structure
TM4 167 A 4.51x51 Structure Structure
TM4 168 L 4.52x52 Structure Structure
TM4 169 S 4.53x53 Structure Structure
TM4 170 A 4.54x54 Structure Structure
TM4 171 V 4.55x55 Structure Structure
TM4 172 I 4.56x56 Structure Structure
TM4 173 S 4.57x57 Structure Structure
TM4 174 L 4.58x58 Structure Structure
TM4 175 A 4.59x59 Structure Structure
TM4 176 P 4.60x60 Structure Structure
TM4 177 L 4.61x61 Structure Structure
TM4 178 L 4.62x62 Structure Structure
TM4 179 F 4.63x63 Structure Structure
TM4 180 G 4.64x64 Structure Structure
ECL2 181 W - Structure Structure
ECL2 182 G - Structure Structure
ECL2 183 E - Structure AF2
ECL2 184 T - Structure Structure
ECL2 185 Y - Structure AF2
ECL2 186 S - Structure Structure
ECL2 187 E - Structure AF2
ECL2 188 G - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 E - Structure AF2
ECL2 191 E - Structure AF2
ECL2 192 C 45.50x50 Structure Structure
ECL2 193 Q 45.51x51 Structure Structure
ECL2 194 V 45.52x52 Structure Structure
ECL2 195 S - Structure Structure
ECL2 196 R - Structure Structure
TM5 197 E 5.35x36 Structure AF2
TM5 198 P 5.36x37 Structure Structure
TM5 199 S 5.37x38 Structure Structure
TM5 200 Y 5.38x39 Structure Structure
TM5 201 A 5.39x40 Structure Structure
TM5 202 V 5.40x41 Structure Structure
TM5 203 F 5.41x42 Structure Structure
TM5 204 S 5.42x43 Structure Structure
TM5 205 T 5.43x44 Structure Structure
TM5 206 V 5.44x45 Structure Structure
TM5 207 G 5.45x46 Structure Structure
TM5 208 A 5.46x461 Structure Structure
TM5 209 F 5.47x47 Structure Structure
TM5 210 Y 5.48x48 Structure Structure
TM5 211 L 5.49x49 Structure Structure
TM5 212 P 5.50x50 Structure Structure
TM5 213 L 5.51x51 Structure Structure
TM5 214 C 5.52x52 Structure Structure
TM5 215 V 5.53x53 Structure Structure
TM5 216 V 5.54x54 Structure Structure
TM5 217 L 5.55x55 Structure Structure
TM5 218 F 5.56x56 Structure Structure
TM5 219 V 5.57x57 Structure Structure
TM5 220 Y 5.58x58 Structure Structure
TM5 221 W 5.59x59 Structure Structure
TM5 222 K 5.60x60 Structure AF2
TM5 223 I 5.61x61 Structure Structure
TM5 224 Y 5.62x62 Structure Structure
TM5 225 K 5.63x63 Structure Structure
TM5 226 A 5.64x64 Structure Structure
TM5 227 A 5.65x65 Structure Structure
TM5 228 K 5.66x66 Structure Structure
TM5 229 F 5.67x67 Structure AF2
TM5 230 R 5.68x68 Structure Structure
TM5 231 V 5.69x69 Structure Structure
TM5 232 G 5.70x70 AF2 AF2
TM5 233 S 5.71x71 AF2 AF2
TM5 234 R 5.72x72 AF2 AF2
TM5 235 K 5.73x73 AF2 AF2
TM5 236 T 5.74x74 AF2 AF2
TM5 237 N 5.75x75 AF2 AF2
TM5 238 S 5.76x76 AF2 AF2
ICL3 239 V - AF2 AF2
ICL3 240 S - AF2 AF2
ICL3 241 P - AF2 AF2
ICL3 242 I - AF2 AF2
ICL3 243 S - AF2 AF2
ICL3 244 E - AF2 AF2
ICL3 245 A - AF2 AF2
ICL3 267 T - AF2 AF2
ICL3 268 F - AF2 AF2
ICL3 269 Q - AF2 AF2
ICL3 270 P - AF2 AF2
ICL3 271 E - AF2 AF2
ICL3 272 G - AF2 AF2
ICL3 273 D - AF2 AF2
TM6 274 T 6.24x24 AF2 AF2
TM6 275 W 6.25x25 AF2 AF2
TM6 276 R 6.26x26 AF2 AF2
TM6 277 E 6.27x27 Structure Structure
TM6 278 Q 6.28x28 Structure AF2
TM6 279 K 6.29x29 Structure AF2
TM6 280 E 6.30x30 Structure Structure
TM6 281 Q 6.31x31 Structure Structure
TM6 282 R 6.32x32 Structure Structure
TM6 283 A 6.33x33 Structure Structure
TM6 284 A 6.34x34 Structure Structure
TM6 285 L 6.35x35 Structure Structure
TM6 286 M 6.36x36 Structure Structure
TM6 287 V 6.37x37 Structure Structure
TM6 288 G 6.38x38 Structure Structure
TM6 289 I 6.39x39 Structure Structure
TM6 290 L 6.40x40 Structure Structure
TM6 291 I 6.41x41 Structure Structure
TM6 292 G 6.42x42 Structure Structure
TM6 293 V 6.43x43 Structure Structure
TM6 294 F 6.44x44 Structure Structure
TM6 295 V 6.45x45 Structure Structure
TM6 296 L 6.46x46 Structure Structure
TM6 297 C 6.47x47 Structure Structure
TM6 298 W 6.48x48 Structure Structure
TM6 299 I 6.49x49 Structure Structure
TM6 300 P 6.50x50 Structure Structure
TM6 301 F 6.51x51 Structure Structure
TM6 302 F 6.52x52 Structure Structure
TM6 303 L 6.53x53 Structure Structure
TM6 304 T 6.54x54 Structure Structure
TM6 305 E 6.55x55 Structure Structure
TM6 306 L 6.56x56 Structure Structure
TM6 307 I 6.57x57 Structure Structure
TM6 308 S 6.58x58 Structure Structure
TM6 309 P 6.59x59 Structure Structure
TM6 310 L 6.60x60 Structure Structure
TM6 311 C 6.61x61 Structure Structure
ECL3 312 S - Structure Structure
ECL3 313 C - Structure Structure
ECL3 314 D - Structure AF2
ECL3 315 I - Structure Structure
TM7 316 P 7.31x30 Structure Structure
TM7 317 A 7.32x31 Structure Structure
TM7 318 I 7.33x32 Structure Structure
TM7 319 W 7.34x33 Structure Structure
TM7 320 K 7.35x34 Structure AF2
TM7 321 S 7.36x35 Structure Structure
TM7 322 I 7.37x36 Structure Structure
TM7 323 F 7.38x37 Structure Structure
TM7 324 L 7.39x38 Structure Structure
TM7 325 W 7.40x39 Structure Structure
TM7 326 L 7.41x40 Structure Structure
TM7 327 G 7.42x41 Structure Structure
TM7 328 Y 7.43x42 Structure Structure
TM7 329 S 7.44x43 Structure Structure
TM7 330 N 7.45x45 Structure Structure
TM7 331 S 7.46x46 Structure Structure
TM7 332 F 7.47x47 Structure Structure
TM7 333 F 7.48x48 Structure Structure
TM7 334 N 7.49x49 Structure Structure
TM7 335 P 7.50x50 Structure Structure
TM7 336 L 7.51x51 Structure AF2
TM7 337 I 7.52x52 Structure Structure
TM7 338 Y 7.53x53 Structure Structure
TM7 339 T 7.54x54 Structure Structure
TM7 340 A 7.55x55 Structure Structure
TM7 341 F 7.56x56 Structure Structure
H8 342 N 8.47x47 Structure Structure
H8 343 K 8.48x48 Structure AF2
H8 344 N 8.49x49 Structure Structure
H8 345 Y 8.50x50 Structure Structure
H8 346 N 8.51x51 Structure Structure
H8 347 S 8.52x52 Structure Structure
H8 348 A 8.53x53 Structure Structure
H8 349 F 8.54x54 Structure AF2
H8 350 K 8.55x55 Structure AF2
H8 351 N 8.56x56 Structure AF2
H8 352 F 8.57x57 Structure AF2
H8 353 F 8.58x58 AF2 AF2
C-term 354 S - AF2 AF2
C-term 355 R - AF2 AF2
C-term 356 Q - AF2 AF2
C-term 357 H - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 147 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL3 S 240 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 S 240 - G.h4s6 N 312 G.h4s6.02
Hydrophobic TM5 S 238 5x76 G.S6 Y 320 G.S6.02
Hydrophobic ICL3 I 242 - G.H4 S 310 G.H4.17
Van-der-waals ICL3 I 242 - G.H4 S 310 G.H4.17
Hydrophobic ICL3 P 241 - G.H3 C 255 G.H3.13
Aromatic TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Polar TM5 N 237 5x75 G.S6 C 321 G.S6.03
Hydrophobic TM6 V 287 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 286 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 286 6x36 G.H5 L 353 G.H5.25
Polar H8 N 342 8x47 G.H5 G 350 G.H5.22
Ionic TM5 R 230 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 238 5x76 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 S 238 5x76 G.h4s6 E 318 G.h4s6.12
Polar ICL3 V 239 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 V 239 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 V 239 - G.S6 I 319 G.S6.01
Hydrophobic TM5 R 230 5x68 G.H5 A 345 G.H5.17
Van-der-waals TM5 R 230 5x68 G.H5 A 345 G.H5.17
Polar ICL3 P 241 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 P 241 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 P 241 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 P 241 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM4 L 151 4x35 G.hns1 A 31 G.hns1.02
Polar ICL3 S 243 - G.h4s6 S 314 G.h4s6.08
Hydrophobic TM5 N 237 5x75 G.S6 I 319 G.S6.01
Van-der-waals TM5 N 237 5x75 G.S6 I 319 G.S6.01
Polar ICL2 H 146 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 146 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 146 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 V 239 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 V 239 - G.H4 E 309 G.H4.16
Polar ICL3 I 242 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 I 242 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 I 242 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 I 242 - G.h4s6 R 313 G.h4s6.03
Hydrophobic ICL2 H 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 147 34x51 G.H5 I 343 G.H5.15
Polar TM6 W 275 6x25 G.h4s6 P 315 G.h4s6.09
Hydrophobic TM6 W 275 6x25 G.h4s6 P 315 G.h4s6.09
Van-der-waals TM6 W 275 6x25 G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL3 V 239 - G.S6 C 321 G.S6.03
Van-der-waals ICL3 V 239 - G.S6 C 321 G.S6.03
Hydrophobic ICL2 M 147 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 147 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 143 3x54 G.H5 N 347 G.H5.19
Polar ICL3 P 241 - G.h4s6 R 313 G.h4s6.03
Hydrophobic ICL3 P 241 - G.h4s6 R 313 G.h4s6.03
Van-der-waals ICL3 P 241 - G.h4s6 R 313 G.h4s6.03
Ionic ICL3 E 244 - G.h4s6 R 313 G.h4s6.03
Polar ICL3 E 244 - G.h4s6 R 313 G.h4s6.03
Hydrophobic ICL3 E 244 - G.h4s6 R 313 G.h4s6.03
Van-der-waals ICL3 E 244 - G.h4s6 R 313 G.h4s6.03
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 V 239 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 V 239 - G.h4s6 E 318 G.h4s6.12
Polar TM6 W 275 6x25 G.H5 Y 354 G.H5.26
Aromatic TM6 W 275 6x25 G.H5 Y 354 G.H5.26
Hydrophobic TM6 W 275 6x25 G.H5 Y 354 G.H5.26
Van-der-waals TM6 W 275 6x25 G.H5 Y 354 G.H5.26
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 353 G.H5.25
Polar TM5 T 236 5x74 G.S6 C 321 G.S6.03
Van-der-waals ICL3 V 239 - G.h4s6 N 312 G.h4s6.02
Polar ICL3 S 240 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 S 240 - G.h4s6 K 317 G.h4s6.11
Van-der-waals ICL3 S 240 - G.h4s6 K 317 G.h4s6.11
Polar ICL3 I 242 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 I 242 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 I 242 - G.H4 E 309 G.H4.16
Polar TM5 S 238 5x76 G.S6 I 319 G.S6.01
Hydrophobic TM5 S 238 5x76 G.S6 I 319 G.S6.01
Van-der-waals TM5 S 238 5x76 G.S6 I 319 G.S6.01
Van-der-waals TM6 R 282 6x32 G.H5 L 353 G.H5.25
Polar TM3 S 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 347 G.H5.19
Ionic TM5 R 234 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 234 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 234 5x72 G.H5 D 341 G.H5.13
Polar ICL3 P 241 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 P 241 - G.h4s6 K 317 G.h4s6.11
Van-der-waals ICL3 P 241 - G.h4s6 K 317 G.h4s6.11
Polar TM5 N 237 5x75 G.S6 Y 320 G.S6.02
Hydrophobic TM5 N 237 5x75 G.S6 Y 320 G.S6.02
Van-der-waals TM5 N 237 5x75 G.S6 Y 320 G.S6.02
Polar ICL3 P 241 - G.h4s6 S 314 G.h4s6.08
Hydrophobic ICL3 P 241 - G.h4s6 S 314 G.h4s6.08
Van-der-waals ICL3 P 241 - G.h4s6 S 314 G.h4s6.08
Hydrophobic TM5 R 234 5x72 G.H5 A 345 G.H5.17
Van-der-waals TM5 R 234 5x72 G.H5 A 345 G.H5.17
Hydrophobic ICL2 H 146 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 H 146 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 S 243 - G.h4s6 R 313 G.h4s6.03
Van-der-waals ICL3 S 243 - G.h4s6 R 313 G.h4s6.03
Polar ICL3 S 243 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 S 243 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 S 243 - G.h4s6 N 312 G.h4s6.02
Hydrophobic TM6 A 283 6x33 G.H5 L 353 G.H5.25
Ionic TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 240 - G.h4s6 E 318 G.h4s6.12
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23