Refined structure (7WU9) of Gi1 - EP3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 135 from structure (38.1%), 219 from model (61.9%)
Residue sidechains - 117 from structure (33.1%), 237 from model (66.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure AF2
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 AF2 AF2
G.s1h1 42 G G.s1h1.03 AF2 AF2
G.s1h1 43 E G.s1h1.04 AF2 AF2
G.s1h1 44 S G.s1h1.05 AF2 AF2
G.s1h1 45 G G.s1h1.06 AF2 AF2
G.H1 46 K G.H1.01 AF2 AF2
G.H1 47 S G.H1.02 AF2 AF2
G.H1 48 T G.H1.03 AF2 AF2
G.H1 49 I G.H1.04 AF2 AF2
G.H1 50 V G.H1.05 AF2 AF2
G.H1 51 K G.H1.06 AF2 AF2
G.H1 52 Q G.H1.07 AF2 AF2
G.H1 53 M G.H1.08 AF2 AF2
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 AF2 AF2
G.s3h2 203 G G.s3h2.02 AF2 AF2
G.s3h2 204 Q G.s3h2.03 AF2 AF2
G.H2 205 R G.H2.01 AF2 AF2
G.H2 206 S G.H2.02 AF2 AF2
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure AF2
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure AF2
G.H2 211 W G.H2.07 Structure AF2
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure AF2
G.S4 226 A G.S4.07 AF2 AF2
G.s4h3 227 L G.s4h3.01 AF2 AF2
G.s4h3 228 S G.s4h3.02 AF2 AF2
G.s4h3 229 D G.s4h3.03 AF2 AF2
G.s4h3 230 Y G.s4h3.04 AF2 AF2
G.s4h3 231 D G.s4h3.05 AF2 AF2
G.s4h3 232 L G.s4h3.06 AF2 AF2
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 AF2 AF2
G.H3 242 R G.H3.01 AF2 AF2
G.H3 243 M G.H3.02 AF2 AF2
G.H3 244 H G.H3.03 AF2 AF2
G.H3 245 E G.H3.04 AF2 AF2
G.H3 246 S G.H3.05 AF2 AF2
G.H3 247 M G.H3.06 AF2 AF2
G.H3 248 K G.H3.07 AF2 AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure AF2
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 AF2 AF2
G.HG 271 K G.HG.01 AF2 AF2
G.HG 272 D G.HG.02 AF2 AF2
G.HG 273 L G.HG.03 AF2 AF2
G.HG 274 F G.HG.04 AF2 AF2
G.HG 275 E G.HG.05 AF2 AF2
G.HG 276 E G.HG.06 AF2 AF2
G.HG 277 K G.HG.07 AF2 AF2
G.HG 278 I G.HG.08 AF2 AF2
G.HG 279 K G.HG.09 AF2 AF2
G.HG 280 K G.HG.12 AF2 AF2
G.HG 281 S G.HG.13 AF2 AF2
G.HG 282 P G.HG.14 AF2 AF2
G.HG 283 L G.HG.15 AF2 AF2
G.HG 284 T G.HG.16 AF2 AF2
G.HG 285 I G.HG.17 AF2 AF2
G.hgh4 286 C G.hgh4.01 AF2 AF2
G.hgh4 287 Y G.hgh4.02 AF2 AF2
G.hgh4 288 P G.hgh4.03 AF2 AF2
G.hgh4 289 E G.hgh4.04 AF2 AF2
G.hgh4 290 Y G.hgh4.05 AF2 AF2
G.hgh4 291 A G.hgh4.06 AF2 AF2
G.hgh4 292 G G.hgh4.07 AF2 AF2
G.hgh4 293 S G.hgh4.08 AF2 AF2
G.H4 294 N G.H4.01 AF2 AF2
G.H4 295 T G.H4.02 AF2 AF2
G.H4 296 Y G.H4.03 AF2 AF2
G.H4 297 E G.H4.04 AF2 AF2
G.H4 298 E G.H4.05 AF2 AF2
G.H4 299 A G.H4.06 AF2 AF2
G.H4 300 A G.H4.07 AF2 AF2
G.H4 301 A G.H4.08 AF2 AF2
G.H4 302 Y G.H4.10 AF2 AF2
G.H4 303 I G.H4.11 AF2 AF2
G.H4 304 Q G.H4.12 AF2 AF2
G.H4 305 C G.H4.13 AF2 AF2
G.H4 306 Q G.H4.14 AF2 AF2
G.H4 307 F G.H4.15 AF2 AF2
G.H4 308 E G.H4.16 AF2 AF2
G.H4 309 D G.H4.17 AF2 AF2
G.h4s6 310 L G.h4s6.01 AF2 AF2
G.h4s6 311 N G.h4s6.02 AF2 AF2
G.h4s6 312 K G.h4s6.03 AF2 AF2
G.h4s6 313 R G.h4s6.04 AF2 AF2
G.h4s6 314 K G.h4s6.08 AF2 AF2
G.h4s6 315 D G.h4s6.09 AF2 AF2
G.h4s6 316 T G.h4s6.10 AF2 AF2
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure AF2
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure AF2
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure AF2
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure AF2
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure AF2
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 270 from structure (71.2%), 109 from model (28.8%)
Residue sidechains - 173 from structure (45.6%), 206 from model (54.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 K - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 R - AF2 AF2
N-term 6 G - AF2 AF2
N-term 7 Y - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 C - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 R - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 H - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 Y - AF2 AF2
N-term 22 T - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 M - AF2 AF2
N-term 25 W - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 E - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 A - AF2 AF2
N-term 32 E - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 R - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 N - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 T - AF2 AF2
N-term 39 R - AF2 AF2
N-term 40 P - AF2 AF2
N-term 41 P - AF2 AF2
N-term 42 G - AF2 AF2
N-term 43 S - AF2 AF2
N-term 44 G - AF2 AF2
N-term 45 E - AF2 AF2
N-term 46 D - AF2 AF2
N-term 47 C - AF2 AF2
N-term 48 G - AF2 AF2
N-term 49 S - AF2 AF2
N-term 50 V - AF2 AF2
N-term 51 S - AF2 AF2
TM1 52 V 1.36x36 AF2 AF2
TM1 53 A 1.37x37 Structure Structure
TM1 54 F 1.38x38 Structure AF2
TM1 55 P 1.39x39 Structure Structure
TM1 56 I 1.40x40 Structure AF2
TM1 57 T 1.41x41 Structure Structure
TM1 58 M 1.42x42 Structure AF2
TM1 59 L 1.43x43 Structure Structure
TM1 60 L 1.44x44 Structure AF2
TM1 61 T 1.45x45 Structure AF2
TM1 62 G 1.46x46 Structure Structure
TM1 63 F 1.47x47 Structure AF2
TM1 64 V 1.48x48 Structure AF2
TM1 65 G 1.49x49 Structure Structure
TM1 66 N 1.50x50 Structure AF2
TM1 67 A 1.51x51 Structure Structure
TM1 68 L 1.52x52 Structure AF2
TM1 69 A 1.53x53 Structure Structure
TM1 70 M 1.54x54 Structure Structure
TM1 71 L 1.55x55 Structure AF2
TM1 72 L 1.56x56 Structure Structure
TM1 73 V 1.57x57 Structure Structure
TM1 74 S 1.58x58 Structure Structure
TM1 75 R 1.59x59 Structure AF2
TM1 76 S 1.60x60 Structure Structure
TM1 77 Y 1.61x61 Structure Structure
TM1 78 R 1.62x62 Structure Structure
ICL1 79 R - Structure Structure
ICL1 80 R - Structure Structure
ICL1 81 E - AF2 AF2
ICL1 82 S - AF2 AF2
ICL1 83 K - Structure Structure
ICL1 84 R - Structure Structure
TM2 85 K 2.36x36 Structure Structure
TM2 86 K 2.37x37 Structure Structure
TM2 87 S 2.38x38 Structure Structure
TM2 88 F 2.39x39 Structure AF2
TM2 89 L 2.40x40 Structure Structure
TM2 90 L 2.41x41 Structure Structure
TM2 91 C 2.42x42 Structure Structure
TM2 92 I 2.43x43 Structure Structure
TM2 93 G 2.44x44 Structure Structure
TM2 94 W 2.45x45 Structure Structure
TM2 95 L 2.46x46 Structure Structure
TM2 96 A 2.47x47 Structure Structure
TM2 97 L 2.48x48 Structure AF2
TM2 98 T 2.49x49 Structure Structure
TM2 99 D 2.50x50 Structure AF2
TM2 100 L 2.51x51 Structure AF2
TM2 101 V 2.52x52 Structure Structure
TM2 102 G 2.53x53 Structure Structure
TM2 103 Q 2.54x54 Structure AF2
TM2 104 L 2.55x55 Structure AF2
TM2 105 L 2.56x56 Structure AF2
TM2 106 T 2.57x57 Structure AF2
TM2 107 T 2.58x58 Structure Structure
TM2 108 P 2.59x59 Structure Structure
TM2 109 V 2.60x60 Structure AF2
TM2 110 V 2.61x61 Structure AF2
TM2 111 I 2.62x62 Structure Structure
TM2 112 V 2.63x63 Structure AF2
TM2 113 V 2.64x64 Structure Structure
TM2 114 Y 2.65x65 Structure Structure
TM2 115 L 2.66x66 Structure AF2
TM2 116 S 2.67x67 Structure Structure
TM2 117 K 2.68x68 Structure AF2
ECL1 118 Q - AF2 AF2
ECL1 119 R 23.49x49 AF2 AF2
ECL1 120 W 23.50x50 Structure Structure
ECL1 121 E 23.51x51 Structure Structure
ECL1 122 H 23.52x52 Structure Structure
ECL1 123 I - Structure Structure
ECL1 124 D - Structure Structure
ECL1 125 P - Structure Structure
ECL1 126 S - Structure Structure
TM3 127 G 3.22x22 Structure Structure
TM3 128 R 3.23x23 Structure AF2
TM3 129 L 3.24x24 Structure AF2
TM3 130 C 3.25x25 Structure Structure
TM3 131 T 3.26x26 Structure AF2
TM3 132 F 3.27x27 Structure AF2
TM3 133 F 3.28x28 Structure AF2
TM3 134 G 3.29x29 Structure Structure
TM3 135 L 3.30x30 Structure AF2
TM3 136 T 3.31x31 Structure Structure
TM3 137 M 3.32x32 Structure Structure
TM3 138 T 3.33x33 Structure Structure
TM3 139 V 3.34x34 Structure AF2
TM3 140 F 3.35x35 Structure Structure
TM3 141 G 3.36x36 Structure Structure
TM3 142 L 3.37x37 Structure AF2
TM3 143 S 3.38x38 Structure Structure
TM3 144 S 3.39x39 Structure Structure
TM3 145 L 3.40x40 Structure Structure
TM3 146 F 3.41x41 Structure AF2
TM3 147 I 3.42x42 Structure Structure
TM3 148 A 3.43x43 Structure Structure
TM3 149 S 3.44x44 Structure Structure
TM3 150 A 3.45x45 Structure Structure
TM3 151 M 3.46x46 Structure AF2
TM3 152 A 3.47x47 Structure Structure
TM3 153 V 3.48x48 Structure Structure
TM3 154 E 3.49x49 Structure Structure
TM3 155 R 3.50x50 Structure Structure
TM3 156 A 3.51x51 Structure Structure
TM3 157 L 3.52x52 Structure AF2
TM3 158 A 3.53x53 Structure Structure
TM3 159 I 3.54x54 Structure Structure
TM3 160 R 3.55x55 Structure Structure
TM3 161 A 3.56x56 Structure Structure
ICL2 162 P 34.50x50 Structure Structure
ICL2 163 H 34.51x51 Structure Structure
ICL2 164 W 34.52x52 Structure Structure
ICL2 165 Y 34.53x53 Structure Structure
ICL2 166 A 34.54x54 Structure Structure
ICL2 167 S 34.55x55 Structure Structure
ICL2 168 H 34.56x56 Structure Structure
ICL2 169 M 34.57x57 Structure Structure
TM4 170 K 4.38x38 Structure AF2
TM4 171 T 4.39x39 Structure Structure
TM4 172 R 4.40x40 Structure AF2
TM4 173 A 4.41x41 Structure AF2
TM4 174 T 4.42x42 Structure Structure
TM4 175 R 4.43x43 Structure AF2
TM4 176 A 4.44x44 Structure Structure
TM4 177 V 4.45x45 Structure Structure
TM4 178 L 4.46x46 Structure Structure
TM4 179 L 4.47x47 Structure AF2
TM4 180 G 4.48x48 Structure Structure
TM4 181 V 4.49x49 Structure Structure
TM4 182 W 4.50x50 Structure AF2
TM4 183 L 4.51x51 Structure AF2
TM4 184 A 4.52x52 Structure Structure
TM4 185 V 4.53x53 Structure AF2
TM4 186 L 4.54x54 Structure Structure
TM4 187 A 4.55x55 Structure Structure
TM4 188 F 4.56x56 Structure Structure
TM4 189 A 4.57x57 Structure Structure
TM4 190 L 4.58x58 Structure AF2
TM4 191 L 4.59x59 Structure AF2
TM4 192 P 4.60x60 Structure Structure
TM4 193 V 4.61x61 Structure AF2
TM4 194 L 4.62x62 Structure AF2
TM4 195 G 4.63x63 Structure Structure
ECL2 196 V - Structure Structure
ECL2 197 G - Structure Structure
ECL2 198 Q - Structure AF2
ECL2 199 Y - Structure Structure
ECL2 200 T - Structure Structure
ECL2 201 V - Structure Structure
ECL2 202 Q - Structure Structure
ECL2 203 W - Structure Structure
ECL2 204 P - Structure Structure
ECL2 205 G - Structure Structure
ECL2 206 T - Structure Structure
ECL2 207 W - Structure Structure
ECL2 208 C 45.50x50 Structure Structure
ECL2 209 F 45.51x51 Structure Structure
ECL2 210 I 45.52x52 Structure Structure
ECL2 211 S - Structure Structure
ECL2 212 T - Structure Structure
ECL2 213 G - AF2 AF2
ECL2 214 R - AF2 AF2
ECL2 215 G - AF2 AF2
ECL2 216 G - AF2 AF2
ECL2 217 N - AF2 AF2
ECL2 218 G - AF2 AF2
ECL2 219 T - AF2 AF2
ECL2 220 S - AF2 AF2
ECL2 221 S - AF2 AF2
ECL2 222 S - AF2 AF2
ECL2 223 H - AF2 AF2
ECL2 224 N - AF2 AF2
TM5 225 W 5.34x34 AF2 AF2
TM5 226 G 5.35x35 Structure Structure
TM5 227 N 5.36x36 Structure Structure
TM5 228 L 5.37x37 Structure Structure
TM5 229 F 5.38x38 Structure AF2
TM5 230 F 5.39x39 Structure Structure
TM5 231 A 5.40x40 Structure Structure
TM5 232 S 5.41x41 Structure Structure
TM5 233 A 5.42x42 Structure Structure
TM5 234 F 5.43x43 Structure Structure
TM5 235 A 5.44x44 Structure Structure
TM5 236 F 5.45x45 Structure Structure
TM5 237 L 5.46x46 Structure AF2
TM5 238 G 5.47x47 Structure Structure
TM5 239 L 5.48x48 Structure AF2
TM5 240 L 5.49x49 Structure AF2
TM5 241 A 5.50x50 Structure Structure
TM5 242 L 5.51x51 Structure AF2
TM5 243 T 5.52x52 Structure AF2
TM5 244 V 5.53x53 Structure Structure
TM5 245 T 5.54x54 Structure Structure
TM5 246 F 5.55x55 Structure AF2
TM5 247 S 5.56x56 Structure Structure
TM5 248 C 5.57x57 Structure Structure
TM5 249 N 5.58x58 Structure Structure
TM5 250 L 5.59x59 Structure AF2
TM5 251 A 5.60x60 Structure Structure
TM5 252 T 5.61x61 Structure Structure
TM5 253 I 5.62x62 Structure Structure
TM5 254 K 5.63x63 Structure AF2
TM5 255 A 5.64x64 Structure Structure
TM5 256 L 5.65x65 Structure Structure
TM5 257 V 5.66x66 Structure AF2
TM5 258 S 5.67x67 Structure AF2
TM5 259 R 5.68x68 Structure Structure
TM5 260 C 5.69x69 Structure Structure
TM5 261 R 5.70x70 Structure AF2
TM5 262 A 5.71x71 Structure Structure
TM5 263 K 5.72x72 Structure AF2
TM5 264 A 5.73x73 Structure Structure
ICL3 265 T - Structure Structure
ICL3 266 A - AF2 AF2
ICL3 267 S - AF2 AF2
ICL3 268 Q - AF2 AF2
TM6 269 S 6.22x22 AF2 AF2
TM6 270 S 6.23x23 Structure Structure
TM6 271 A 6.24x24 Structure Structure
TM6 272 Q 6.25x25 Structure AF2
TM6 273 W 6.26x26 Structure Structure
TM6 274 G 6.27x27 Structure Structure
TM6 275 R 6.28x28 Structure AF2
TM6 276 I 6.29x29 Structure Structure
TM6 277 T 6.30x30 Structure Structure
TM6 278 T 6.31x31 Structure Structure
TM6 279 E 6.32x32 Structure Structure
TM6 280 T 6.33x33 Structure Structure
TM6 281 A 6.34x34 Structure Structure
TM6 282 I 6.35x35 Structure AF2
TM6 283 Q 6.36x36 Structure Structure
TM6 284 L 6.37x37 Structure Structure
TM6 285 M 6.38x38 Structure AF2
TM6 286 G 6.39x39 Structure Structure
TM6 287 I 6.40x40 Structure AF2
TM6 288 M 6.41x41 Structure Structure
TM6 289 C 6.42x42 Structure AF2
TM6 290 V 6.43x43 Structure Structure
TM6 291 L 6.44x44 Structure Structure
TM6 292 S 6.45x45 Structure Structure
TM6 293 V 6.46x46 Structure AF2
TM6 294 C 6.47x47 Structure Structure
TM6 295 W 6.48x48 Structure Structure
TM6 296 S 6.49x49 Structure Structure
TM6 297 P 6.50x50 Structure Structure
TM6 298 L 6.51x51 Structure Structure
TM6 299 L 6.52x52 Structure AF2
TM6 300 I 6.53x53 Structure AF2
TM6 301 M 6.54x54 Structure AF2
TM6 302 M 6.55x55 Structure AF2
TM6 303 L 6.56x56 Structure AF2
TM6 304 K 6.57x57 Structure AF2
TM6 305 M 6.58x58 Structure AF2
TM6 306 I 6.59x59 Structure Structure
TM6 307 F 6.60x60 Structure AF2
TM6 308 N 6.61x61 Structure Structure
TM6 309 Q 6.62x62 AF2 AF2
TM6 310 T 6.63x63 AF2 AF2
TM6 311 S 6.64x64 AF2 AF2
ECL3 312 V - AF2 AF2
ECL3 313 E - AF2 AF2
ECL3 314 H - AF2 AF2
ECL3 315 C - AF2 AF2
ECL3 316 K - AF2 AF2
TM7 317 T 7.24x23 AF2 AF2
TM7 318 H 7.25x24 AF2 AF2
TM7 319 T 7.26x25 AF2 AF2
TM7 320 E 7.27x26 AF2 AF2
TM7 321 K 7.28x27 AF2 AF2
TM7 322 Q 7.29x28 AF2 AF2
TM7 323 K 7.30x29 Structure Structure
TM7 324 E 7.31x30 Structure AF2
TM7 325 C 7.32x31 Structure Structure
TM7 326 N 7.33x32 Structure Structure
TM7 327 F 7.34x33 Structure AF2
TM7 328 F 7.35x34 Structure AF2
TM7 329 L 7.36x35 Structure AF2
TM7 330 I 7.37x36 Structure Structure
TM7 331 A 7.38x37 Structure Structure
TM7 332 V 7.39x38 Structure AF2
TM7 333 R 7.40x39 Structure AF2
TM7 334 L 7.41x40 Structure AF2
TM7 335 A 7.42x41 Structure Structure
TM7 336 S 7.43x42 Structure Structure
TM7 337 L 7.44x43 Structure AF2
TM7 338 N 7.45x45 Structure Structure
TM7 339 Q 7.46x46 Structure AF2
TM7 340 I 7.47x47 Structure AF2
TM7 341 L 7.48x48 Structure AF2
TM7 342 D 7.49x49 Structure AF2
TM7 343 P 7.50x50 Structure Structure
TM7 344 W 7.51x51 Structure Structure
TM7 345 V 7.52x52 Structure AF2
TM7 346 Y 7.53x53 Structure Structure
TM7 347 L 7.54x54 Structure AF2
TM7 348 L 7.55x55 Structure AF2
TM7 349 L 7.56x56 Structure AF2
H8 350 R 8.47x47 Structure Structure
H8 351 K 8.48x48 Structure AF2
H8 352 I 8.49x49 Structure AF2
H8 353 L 8.50x50 Structure AF2
H8 354 L 8.51x51 Structure AF2
H8 355 R 8.52x52 Structure Structure
H8 356 K 8.53x53 Structure AF2
H8 357 F 8.54x54 Structure Structure
H8 358 C 8.55x55 AF2 AF2
H8 359 Q 8.56x56 AF2 AF2
H8 360 I 8.57x57 AF2 AF2
H8 361 R 8.58x58 AF2 AF2
H8 362 Y 8.59x59 AF2 AF2
H8 363 H 8.60x60 AF2 AF2
H8 364 T 8.61x61 AF2 AF2
H8 365 N 8.62x62 AF2 AF2
H8 366 N 8.63x63 AF2 AF2
H8 367 Y 8.64x64 AF2 AF2
H8 368 A 8.65x65 AF2 AF2
H8 369 S 8.66x66 AF2 AF2
C-term 370 S - AF2 AF2
C-term 371 S - AF2 AF2
C-term 372 T - AF2 AF2
C-term 373 S - AF2 AF2
C-term 374 L - AF2 AF2
C-term 375 P - AF2 AF2
C-term 376 C - AF2 AF2
C-term 377 Q - AF2 AF2
C-term 378 C - AF2 AF2
C-term 379 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 Q 272 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 Q 272 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 Q 272 6x25 G.h4s6 K 314 G.h4s6.08
Aromatic TM6 W 273 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 W 273 6x26 G.H5 K 345 G.H5.17
Polar ICL2 Y 165 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 165 34x53 G.H5 C 351 G.H5.23
Polar ICL2 S 167 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 167 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 256 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 158 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 155 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 155 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM6 Q 283 6x36 G.H5 L 353 G.H5.25
Polar TM6 Q 272 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 Q 272 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 Q 272 6x25 G.h4s6 D 315 G.h4s6.09
Ionic ICL1 R 84 - G.H5 D 350 G.H5.22
Polar ICL1 R 84 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 84 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 84 - G.H5 D 350 G.H5.22
Hydrophobic TM2 F 88 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 S 167 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 167 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 S 269 6x22 G.S6 Y 320 G.S6.02
Van-der-waals TM6 S 269 6x22 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 Y 165 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 165 34x53 G.H5 N 347 G.H5.19
Polar TM3 E 154 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 154 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 E 154 3x49 G.H5 C 351 G.H5.23
Polar TM6 S 269 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 269 6x22 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 269 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 162 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 162 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 276 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 276 6x29 G.H5 F 354 G.H5.26
Polar TM3 R 155 3x50 G.H5 G 352 G.H5.24
Polar ICL3 S 267 - G.H4 Q 304 G.H4.12
Polar TM6 Q 283 6x36 G.H5 G 352 G.H5.24
Ionic H8 R 361 8x58 G.h4s6 D 315 G.h4s6.09
Polar H8 R 361 8x58 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 R 361 8x58 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 R 361 8x58 G.h4s6 D 315 G.h4s6.09
Polar TM2 K 85 2x36 G.H5 K 349 G.H5.21
Hydrophobic TM2 K 85 2x36 G.H5 K 349 G.H5.21
Van-der-waals TM2 K 85 2x36 G.H5 K 349 G.H5.21
Polar ICL3 Q 268 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 Q 268 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 Q 268 - G.H4 E 308 G.H4.16
Ionic TM2 K 85 2x36 G.H5 D 350 G.H5.22
Polar TM2 K 85 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM2 F 88 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 F 88 2x39 G.H5 G 352 G.H5.24
Hydrophobic ICL2 H 163 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 162 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 162 34x50 G.H5 N 347 G.H5.19
Polar TM5 K 263 5x72 G.S6 Y 320 G.S6.02
Polar ICL1 S 82 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 162 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 162 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 159 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 159 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 280 6x33 G.H5 L 353 G.H5.25
Ionic TM5 K 263 5x72 G.H5 D 341 G.H5.13
Polar TM5 K 263 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 263 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 263 5x72 G.H5 D 341 G.H5.13
Polar TM3 R 155 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 159 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 159 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 158 3x53 G.H5 C 351 G.H5.23
Polar TM5 R 259 5x68 G.H5 T 340 G.H5.12
Polar TM2 S 87 2x38 G.H5 D 350 G.H5.22
Hydrophobic ICL2 S 167 34x55 G.HN E 28 G.HN.52
Polar ICL2 H 168 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 168 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 168 34x56 G.hns1 R 32 G.hns1.03