Refined structure (7X1U) of Gq - TRH1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 206 from structure (57.4%), 153 from model (42.6%)
Residue sidechains - 87 from structure (24.2%), 272 from model (75.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 AF2 AF2
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure AF2
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure AF2
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure AF2
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure AF2
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 AF2 AF2
G.s6h5 331 A G.s6h5.03 AF2 AF2
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure AF2
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 268 from structure (80.0%), 67 from model (20.0%)
Residue sidechains - 213 from structure (63.6%), 122 from model (36.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 V - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 Q - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 Q - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 Q - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 R - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 V - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 A - AF2 AF2
TM1 22 L 1.29x29 AF2 AF2
TM1 23 E 1.30x30 AF2 AF2
TM1 24 Y 1.31x31 AF2 AF2
TM1 25 Q 1.32x32 AF2 AF2
TM1 26 V 1.33x33 AF2 AF2
TM1 27 V 1.34x34 Structure AF2
TM1 28 T 1.35x35 Structure Structure
TM1 29 I 1.36x36 Structure AF2
TM1 30 L 1.37x37 Structure AF2
TM1 31 L 1.38x38 Structure Structure
TM1 32 V 1.39x39 Structure Structure
TM1 33 L 1.40x40 Structure AF2
TM1 34 I 1.41x41 Structure Structure
TM1 35 I 1.42x42 Structure Structure
TM1 36 C 1.43x43 Structure Structure
TM1 37 G 1.44x44 Structure Structure
TM1 38 L 1.45x45 Structure Structure
TM1 39 G 1.46x46 Structure Structure
TM1 40 I 1.47x47 Structure AF2
TM1 41 V 1.48x48 Structure Structure
TM1 42 G 1.49x49 Structure Structure
TM1 43 N 1.50x50 Structure Structure
TM1 44 I 1.51x51 Structure Structure
TM1 45 M 1.52x52 Structure AF2
TM1 46 V 1.53x53 Structure Structure
TM1 47 V 1.54x54 Structure Structure
TM1 48 L 1.55x55 Structure AF2
TM1 49 V 1.56x56 Structure Structure
TM1 50 V 1.57x57 Structure Structure
TM1 51 M 1.58x58 Structure Structure
TM1 52 R 1.59x59 Structure AF2
TM1 53 T 1.60x60 Structure Structure
ICL1 54 K 12.48x48 Structure Structure
ICL1 55 H 12.49x49 Structure AF2
ICL1 56 M 12.50x50 Structure AF2
ICL1 57 R 12.51x51 Structure AF2
TM2 58 T 2.37x37 Structure Structure
TM2 59 P 2.38x38 Structure Structure
TM2 60 T 2.39x39 Structure Structure
TM2 61 N 2.40x40 Structure Structure
TM2 62 C 2.41x41 Structure Structure
TM2 63 Y 2.42x42 Structure Structure
TM2 64 L 2.43x43 Structure Structure
TM2 65 V 2.44x44 Structure Structure
TM2 66 S 2.45x45 Structure Structure
TM2 67 L 2.46x46 Structure Structure
TM2 68 A 2.47x47 Structure Structure
TM2 69 V 2.48x48 Structure Structure
TM2 70 A 2.49x49 Structure Structure
TM2 71 D 2.50x50 Structure AF2
TM2 72 L 2.51x51 Structure Structure
TM2 73 M 2.52x52 Structure Structure
TM2 74 V 2.53x53 Structure Structure
TM2 75 L 2.54x54 Structure AF2
TM2 76 V 2.55x55 Structure Structure
TM2 77 A 2.56x551 Structure Structure
TM2 78 A 2.57x56 Structure Structure
TM2 79 G 2.58x57 Structure Structure
TM2 80 L 2.59x58 Structure AF2
TM2 81 P 2.60x59 Structure Structure
TM2 82 N 2.61x60 Structure Structure
TM2 83 I 2.62x61 Structure AF2
TM2 84 T 2.63x62 Structure Structure
TM2 85 D 2.64x63 Structure Structure
TM2 86 S 2.65x64 Structure Structure
TM2 87 I 2.66x65 Structure AF2
TM2 88 Y 2.67x66 Structure AF2
ECL1 89 G - Structure Structure
ECL1 90 S 23.49x49 Structure Structure
ECL1 91 W 23.50x50 Structure AF2
ECL1 92 V 23.51x51 Structure Structure
ECL1 93 Y 23.52x52 Structure Structure
TM3 94 G 3.21x21 Structure Structure
TM3 95 Y 3.22x22 Structure Structure
TM3 96 V 3.23x23 Structure AF2
TM3 97 G 3.24x24 Structure Structure
TM3 98 C 3.25x25 Structure Structure
TM3 99 L 3.26x26 Structure Structure
TM3 100 C 3.27x27 Structure Structure
TM3 101 I 3.28x28 Structure Structure
TM3 102 T 3.29x29 Structure Structure
TM3 103 Y 3.30x30 Structure Structure
TM3 104 L 3.31x31 Structure Structure
TM3 105 Q 3.32x32 Structure Structure
TM3 106 Y 3.33x33 Structure Structure
TM3 107 L 3.34x34 Structure Structure
TM3 108 G 3.35x35 Structure Structure
TM3 109 I 3.36x36 Structure Structure
TM3 110 N 3.37x37 Structure Structure
TM3 111 A 3.38x38 Structure Structure
TM3 112 S 3.39x39 Structure Structure
TM3 113 S 3.40x40 Structure Structure
TM3 114 C 3.41x41 Structure Structure
TM3 115 S 3.42x42 Structure Structure
TM3 116 I 3.43x43 Structure Structure
TM3 117 T 3.44x44 Structure Structure
TM3 118 A 3.45x45 Structure Structure
TM3 119 F 3.46x46 Structure Structure
TM3 120 T 3.47x47 Structure Structure
TM3 121 I 3.48x48 Structure Structure
TM3 122 E 3.49x49 Structure AF2
TM3 123 R 3.50x50 Structure Structure
TM3 124 Y 3.51x51 Structure Structure
TM3 125 I 3.52x52 Structure Structure
TM3 126 A 3.53x53 Structure Structure
TM3 127 I 3.54x54 Structure Structure
TM3 128 C 3.55x55 Structure Structure
TM3 129 H 3.56x56 Structure Structure
ICL2 130 P 34.50x50 Structure Structure
ICL2 131 I 34.51x51 Structure Structure
ICL2 132 K 34.52x52 Structure AF2
ICL2 133 A 34.53x53 Structure Structure
ICL2 134 Q 34.54x54 Structure Structure
ICL2 135 F 34.55x55 Structure Structure
ICL2 136 L 34.56x56 Structure Structure
ICL2 137 C 34.57x57 Structure Structure
TM4 138 T 4.38x38 Structure Structure
TM4 139 F 4.39x39 Structure Structure
TM4 140 S 4.40x40 Structure Structure
TM4 141 R 4.41x41 Structure Structure
TM4 142 A 4.42x42 Structure Structure
TM4 143 K 4.43x43 Structure Structure
TM4 144 K 4.44x44 Structure Structure
TM4 145 I 4.45x45 Structure Structure
TM4 146 I 4.46x46 Structure Structure
TM4 147 I 4.47x47 Structure Structure
TM4 148 F 4.48x48 Structure Structure
TM4 149 V 4.49x49 Structure Structure
TM4 150 W 4.50x50 Structure Structure
TM4 151 A 4.51x51 Structure Structure
TM4 152 F 4.52x52 Structure Structure
TM4 153 T 4.53x53 Structure Structure
TM4 154 S 4.54x54 Structure Structure
TM4 155 L 4.55x55 Structure Structure
TM4 156 Y 4.56x56 Structure Structure
TM4 157 C 4.57x57 Structure Structure
TM4 158 M 4.58x58 Structure AF2
TM4 159 L 4.59x59 Structure Structure
TM4 160 W 4.60x60 Structure AF2
TM4 161 F 4.61x61 Structure Structure
TM4 162 F 4.62x62 Structure Structure
TM4 163 L 4.63x63 Structure AF2
TM4 164 L 4.64x64 Structure Structure
ECL2 165 D - Structure AF2
ECL2 166 L - Structure Structure
ECL2 167 N - Structure Structure
ECL2 168 I - Structure Structure
ECL2 169 S - Structure Structure
ECL2 170 T - Structure Structure
ECL2 171 Y - Structure AF2
ECL2 172 K - Structure AF2
ECL2 173 D - Structure AF2
ECL2 174 A - Structure Structure
ECL2 175 I - Structure AF2
ECL2 176 V - Structure AF2
ECL2 177 I - Structure AF2
ECL2 178 S - Structure Structure
ECL2 179 C 45.50x50 Structure Structure
ECL2 180 G 45.51x51 Structure Structure
ECL2 181 Y 45.52x52 Structure Structure
ECL2 182 K - Structure AF2
TM5 183 I 5.30x30 Structure AF2
TM5 184 S 5.31x31 Structure Structure
TM5 185 R 5.32x32 Structure Structure
TM5 186 N 5.33x33 Structure AF2
TM5 187 Y 5.34x34 Structure AF2
TM5 188 Y 5.35x35 Structure AF2
TM5 189 S 5.36x36 Structure Structure
TM5 190 P 5.37x37 Structure Structure
TM5 191 I 5.38x38 Structure Structure
TM5 192 Y 5.39x39 Structure Structure
TM5 193 L 5.40x40 Structure Structure
TM5 194 M 5.41x41 Structure Structure
TM5 195 D 5.42x42 Structure Structure
TM5 196 F 5.43x43 Structure Structure
TM5 197 G 5.44x44 Structure Structure
TM5 198 V 5.45x45 Structure Structure
TM5 199 F 5.46x46 Structure AF2
TM5 200 Y 5.47x47 Structure Structure
TM5 201 V 5.48x48 Structure Structure
TM5 202 V 5.49x49 Structure Structure
TM5 203 P 5.50x50 Structure Structure
TM5 204 M 5.51x51 Structure Structure
TM5 205 I 5.52x52 Structure Structure
TM5 206 L 5.53x53 Structure Structure
TM5 207 A 5.54x54 Structure Structure
TM5 208 T 5.55x55 Structure AF2
TM5 209 V 5.56x56 Structure Structure
TM5 210 L 5.57x57 Structure Structure
TM5 211 Y 5.58x58 Structure Structure
TM5 212 G 5.59x59 Structure Structure
TM5 213 F 5.60x60 Structure Structure
TM5 214 I 5.61x61 Structure Structure
TM5 215 A 5.62x62 Structure Structure
TM5 216 R 5.63x63 Structure Structure
TM5 217 I 5.64x64 Structure Structure
TM5 218 L 5.65x65 Structure Structure
TM5 219 F 5.66x66 Structure AF2
TM5 220 L 5.67x67 Structure Structure
TM5 221 N 5.68x68 Structure AF2
TM5 222 P 5.69x69 AF2 AF2
TM5 223 I 5.70x70 AF2 AF2
TM5 224 P 5.71x71 AF2 AF2
TM5 225 S 5.72x72 AF2 AF2
TM5 226 D 5.73x73 AF2 AF2
TM5 227 P 5.74x74 AF2 AF2
TM5 228 K 5.75x75 AF2 AF2
TM5 229 E 5.76x76 AF2 AF2
ICL3 230 N - AF2 AF2
ICL3 231 S - AF2 AF2
ICL3 232 K - AF2 AF2
ICL3 233 T - AF2 AF2
ICL3 234 W - AF2 AF2
ICL3 235 K - AF2 AF2
ICL3 236 N - AF2 AF2
ICL3 248 N - AF2 AF2
ICL3 249 T - AF2 AF2
ICL3 250 S - AF2 AF2
ICL3 251 N - AF2 AF2
ICL3 252 R - AF2 AF2
ICL3 253 C - AF2 AF2
ICL3 254 F - AF2 AF2
TM6 255 N 6.24x24 AF2 AF2
TM6 256 S 6.25x25 AF2 AF2
TM6 257 T 6.26x26 AF2 AF2
TM6 258 V 6.27x27 AF2 AF2
TM6 259 S 6.28x28 AF2 AF2
TM6 260 S 6.29x29 AF2 AF2
TM6 261 R 6.30x30 AF2 AF2
TM6 262 K 6.31x31 Structure Structure
TM6 263 Q 6.32x32 Structure Structure
TM6 264 V 6.33x33 Structure Structure
TM6 265 T 6.34x34 Structure Structure
TM6 266 K 6.35x35 Structure AF2
TM6 267 M 6.36x36 Structure Structure
TM6 268 L 6.37x37 Structure Structure
TM6 269 A 6.38x38 Structure Structure
TM6 270 V 6.39x39 Structure Structure
TM6 271 V 6.40x40 Structure Structure
TM6 272 V 6.41x41 Structure Structure
TM6 273 I 6.42x42 Structure Structure
TM6 274 L 6.43x43 Structure Structure
TM6 275 F 6.44x44 Structure AF2
TM6 276 A 6.45x45 Structure Structure
TM6 277 L 6.46x46 Structure Structure
TM6 278 L 6.47x47 Structure Structure
TM6 279 W 6.48x48 Structure Structure
TM6 280 M 6.49x49 Structure AF2
TM6 281 P 6.50x50 Structure Structure
TM6 282 Y 6.51x51 Structure Structure
TM6 283 R 6.52x52 Structure Structure
TM6 284 T 6.53x53 Structure Structure
TM6 285 L 6.54x54 Structure Structure
TM6 286 V 6.55x55 Structure Structure
TM6 287 V 6.56x56 Structure AF2
TM6 288 V 6.57x57 Structure Structure
TM6 289 N 6.58x58 Structure Structure
TM6 290 S 6.59x59 Structure Structure
TM6 291 F 6.60x60 Structure AF2
TM6 292 L 6.61x61 Structure AF2
ECL3 293 S - Structure Structure
ECL3 294 S - Structure Structure
ECL3 295 P - Structure Structure
ECL3 296 F - Structure Structure
ECL3 297 Q - Structure AF2
TM7 298 E 7.31x30 Structure Structure
TM7 299 N 7.32x31 Structure AF2
TM7 300 W 7.33x32 Structure AF2
TM7 301 F 7.34x33 Structure Structure
TM7 302 L 7.35x34 Structure Structure
TM7 303 L 7.36x35 Structure Structure
TM7 304 F 7.37x36 Structure Structure
TM7 305 C 7.38x37 Structure Structure
TM7 306 R 7.39x38 Structure Structure
TM7 307 I 7.40x39 Structure Structure
TM7 308 C 7.41x40 Structure Structure
TM7 309 I 7.42x41 Structure Structure
TM7 310 Y 7.43x42 Structure Structure
TM7 311 L 7.44x43 Structure Structure
TM7 312 N 7.45x45 Structure Structure
TM7 313 S 7.46x46 Structure Structure
TM7 314 A 7.47x47 Structure Structure
TM7 315 I 7.48x48 Structure Structure
TM7 316 N 7.49x49 Structure Structure
TM7 317 P 7.50x50 Structure Structure
TM7 318 V 7.51x51 Structure Structure
TM7 319 I 7.52x52 Structure Structure
TM7 320 Y 7.53x53 Structure Structure
TM7 321 N 7.54x54 Structure Structure
TM7 322 L 7.55x55 Structure Structure
TM7 323 M 7.56x56 Structure AF2
H8 324 S 8.47x47 Structure Structure
H8 325 Q 8.48x48 Structure AF2
H8 326 K 8.49x49 Structure Structure
H8 327 F 8.50x50 Structure AF2
H8 328 R 8.51x51 Structure Structure
H8 329 A 8.52x52 Structure Structure
H8 330 A 8.53x53 Structure Structure
H8 331 F 8.54x54 Structure Structure
H8 332 R 8.55x55 Structure AF2
H8 333 K 8.56x56 Structure AF2
H8 334 L 8.57x57 Structure AF2
H8 335 C 8.58x58 AF2 AF2
H8 336 N 8.59x59 AF2 AF2
C-term 337 C - AF2 AF2
C-term 338 K - AF2 AF2
C-term 339 Q - AF2 AF2
C-term 340 K - AF2 AF2
C-term 341 P - AF2 AF2
C-term 342 T - AF2 AF2
C-term 343 E - AF2 AF2
C-term 344 K - AF2 AF2
C-term 345 P - AF2 AF2
C-term 346 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 130 34x50 G.H5 N 352 G.H5.19
Polar ICL2 Q 134 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 37 G.hns1.02
Polar TM7 N 321 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM5 E 229 5x76 G.H4 E 307 G.H4.09
Van-der-waals TM5 E 229 5x76 G.H4 E 307 G.H4.09
Polar ICL2 F 135 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 F 135 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 F 135 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM5 L 218 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 218 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 127 3x54 G.H5 N 352 G.H5.19
Van-der-waals TM3 I 127 3x54 G.H5 N 352 G.H5.19
Polar TM3 E 122 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 122 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 122 3x49 G.H5 Y 356 G.H5.23
Hydrophobic H8 K 326 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 K 326 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 Q 325 8x48 G.H5 K 354 G.H5.21
Polar ICL2 C 137 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 C 137 34x57 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 60 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 214 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 L 349 G.H5.16
Polar ICL2 F 135 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 F 135 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 F 135 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM5 I 217 5x64 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 127 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM3 F 119 3x46 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 264 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM6 V 264 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 264 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 F 135 34x55 G.S1 L 40 G.S1.02
Hydrophobic TM4 T 138 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 I 131 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM3 I 127 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 127 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 131 34x51 G.H5 F 341 G.H5.08
Polar H8 S 324 8x47 G.H5 K 354 G.H5.21
Polar H8 S 324 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 324 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 324 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 268 6x37 G.H5 L 358 G.H5.25
Hydrophobic H8 K 326 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 K 326 8x49 G.H5 E 355 G.H5.22
Hydrophobic ICL2 I 131 34x51 G.S3 V 199 G.S3.01
Polar TM2 T 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 58 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 58 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM3 A 126 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 W 234 - G.H4 K 311 G.H4.13
Hydrophobic TM5 L 218 5x65 G.H5 L 349 G.H5.16
Polar TM3 R 123 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 123 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 123 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM2 L 64 2x43 G.H5 N 357 G.H5.24
Hydrophobic ICL2 I 131 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 I 131 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM5 P 224 5x71 G.S6 Y 325 G.S6.02
Polar TM7 Y 320 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 320 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 320 7x53 G.H5 N 357 G.H5.24
Polar H8 S 324 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 324 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 324 8x47 G.H5 V 359 G.H5.26
Polar TM6 R 261 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 V 264 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 264 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 127 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 349 G.H5.16
Polar H8 Q 325 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 Q 325 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 Q 325 8x48 G.H5 V 359 G.H5.26
Polar TM3 A 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 352 G.H5.19
Polar TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Ionic TM5 D 226 5x73 G.H4 R 306 G.H4.08