Refined structure (7XXH) of G11 - P2Y1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 226 from structure (63.0%), 133 from model (37.0%)
Residue sidechains - 15 from structure (4.2%), 344 from model (95.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 Structure AF2
G.HN 4 E G.HN.04 Structure AF2
G.HN 5 S G.HN.05 Structure AF2
G.HN 6 M G.HN.06 Structure AF2
G.HN 7 M G.HN.07 Structure AF2
G.HN 8 A G.HN.08 Structure AF2
G.HN 9 C G.HN.09 Structure AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure AF2
G.HN 13 D G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 V G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 S G.HN.36 Structure AF2
G.HN 19 K G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 A G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure AF2
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 K G.HN.45 Structure Structure
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure AF2
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure AF2
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure AF2
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure AF2
G.S1 43 L G.S1.05 Structure AF2
G.S1 44 L G.S1.06 Structure AF2
G.S1 45 L G.S1.07 Structure AF2
G.s1h1 46 G G.s1h1.01 Structure AF2
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure AF2
G.s1h1 51 G G.s1h1.06 Structure AF2
G.H1 52 K G.H1.01 Structure AF2
G.H1 53 S G.H1.02 Structure AF2
G.H1 54 T G.H1.03 Structure AF2
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 Structure AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 A G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 E H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 E H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 L H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 Q H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 N H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 L H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 I H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 T H.hbhc.04 AF2 AF2
H.hbhc 123 T H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 H H.HC.01 AF2 AF2
H.HC 127 Q H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 S H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 T H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 E H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 A H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 T H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 V H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 I H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 T H.hehf.01 AF2 AF2
H.hehf 170 L H.hehf.02 AF2 AF2
H.hehf 171 G H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 Structure Structure
G.hfs2 182 V G.hfs2.01 Structure AF2
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure AF2
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure AF2
G.S2 189 I G.S2.01 Structure AF2
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure AF2
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 E G.s2s3.01 Structure AF2
G.s2s3 198 N G.s2s3.02 Structure AF2
G.S3 199 I G.S3.01 Structure AF2
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure AF2
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure AF2
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure AF2
G.S3 206 V G.S3.08 Structure AF2
G.s3h2 207 G G.s3h2.01 Structure AF2
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure AF2
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure AF2
G.H2 216 W G.H2.07 Structure AF2
G.H2 217 I G.H2.08 Structure AF2
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure AF2
G.h2s4 220 F G.h2s4.01 Structure AF2
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure AF2
G.h2s4 224 T G.h2s4.05 Structure AF2
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure AF2
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure AF2
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure AF2
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 AF2 AF2
G.s4h3 234 E G.s4h3.03 AF2 AF2
G.s4h3 235 Y G.s4h3.04 AF2 AF2
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 Structure AF2
G.s4h3 238 V G.s4h3.07 Structure AF2
G.s4h3 239 L G.s4h3.08 Structure AF2
G.s4h3 240 V G.s4h3.09 Structure AF2
G.s4h3 241 E G.s4h3.10 Structure AF2
G.s4h3 242 S G.s4h3.11 Structure AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure AF2
G.s4h3 245 E G.s4h3.14 Structure AF2
G.s4h3 246 N G.s4h3.15 Structure AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure AF2
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure AF2
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure AF2
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure AF2
G.S5 269 V G.S5.02 Structure AF2
G.S5 270 I G.S5.03 Structure AF2
G.S5 271 L G.S5.04 Structure AF2
G.S5 272 F G.S5.05 Structure AF2
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure AF2
G.s5hg 275 K G.s5hg.01 Structure AF2
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure AF2
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure AF2
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 D G.HG.06 Structure AF2
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 L G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure AF2
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure AF2
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure AF2
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 F G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure AF2
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure AF2
G.H4 309 I G.H4.11 Structure AF2
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure AF2
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure AF2
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure AF2
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure AF2
G.S6 328 F G.S6.05 Structure AF2
G.s6h5 329 T G.s6h5.01 Structure AF2
G.s6h5 330 C G.s6h5.02 Structure AF2
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure AF2
G.H5 334 T G.H5.01 Structure AF2
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure AF2
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure AF2
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure AF2
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure AF2
G.H5 346 D G.H5.13 Structure AF2
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure AF2
G.H5 349 L G.H5.16 Structure AF2
G.H5 350 Q G.H5.17 Structure AF2
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure AF2
G.H5 353 L G.H5.20 Structure AF2
G.H5 354 K G.H5.21 AF2 AF2
G.H5 355 E G.H5.22 AF2 AF2
G.H5 356 Y G.H5.23 AF2 AF2
G.H5 357 N G.H5.24 AF2 AF2
G.H5 358 L G.H5.25 AF2 AF2
G.H5 359 V G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 301 from structure (86.0%), 49 from model (14.0%)
Residue sidechains - 276 from structure (78.9%), 74 from model (21.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 T - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 V - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 W - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 D - AF2 AF2
N-term 15 A - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 F - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 W - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 N - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 T - AF2 AF2
N-term 30 V - AF2 AF2
N-term 31 A - AF2 AF2
N-term 32 S - AF2 AF2
N-term 33 T - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 V - AF2 AF2
N-term 37 S - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 S - AF2 AF2
N-term 40 F - Structure AF2
N-term 41 K - Structure AF2
N-term 42 C - Structure Structure
N-term 43 A - Structure Structure
N-term 44 L - Structure AF2
N-term 45 T - Structure Structure
N-term 46 K - Structure AF2
N-term 47 T - Structure Structure
N-term 48 G - Structure Structure
TM1 49 F 1.30x30 Structure AF2
TM1 50 Q 1.31x31 Structure Structure
TM1 51 F 1.32x32 Structure AF2
TM1 52 Y 1.33x33 Structure AF2
TM1 53 Y 1.34x34 Structure Structure
TM1 54 L 1.35x35 Structure Structure
TM1 55 P 1.36x36 Structure Structure
TM1 56 A 1.37x37 Structure Structure
TM1 57 V 1.38x38 Structure Structure
TM1 58 Y 1.39x39 Structure Structure
TM1 59 I 1.40x40 Structure Structure
TM1 60 L 1.41x41 Structure Structure
TM1 61 V 1.42x42 Structure Structure
TM1 62 F 1.43x43 Structure Structure
TM1 63 I 1.44x44 Structure Structure
TM1 64 I 1.45x45 Structure Structure
TM1 65 G 1.46x46 Structure Structure
TM1 66 F 1.47x47 Structure AF2
TM1 67 L 1.48x48 Structure Structure
TM1 68 G 1.49x49 Structure Structure
TM1 69 N 1.50x50 Structure Structure
TM1 70 S 1.51x51 Structure Structure
TM1 71 V 1.52x52 Structure Structure
TM1 72 A 1.53x53 Structure Structure
TM1 73 I 1.54x54 Structure Structure
TM1 74 W 1.55x55 Structure Structure
TM1 75 M 1.56x56 Structure Structure
TM1 76 F 1.57x57 Structure Structure
TM1 77 V 1.58x58 Structure Structure
TM1 78 F 1.59x59 Structure Structure
TM1 79 H 1.60x60 Structure Structure
ICL1 80 M - Structure Structure
ICL1 81 K - Structure Structure
ICL1 82 P - Structure Structure
ICL1 83 W - Structure Structure
TM2 84 S 2.37x37 Structure Structure
TM2 85 G 2.38x38 Structure Structure
TM2 86 I 2.39x39 Structure Structure
TM2 87 S 2.40x40 Structure Structure
TM2 88 V 2.41x41 Structure Structure
TM2 89 Y 2.42x42 Structure Structure
TM2 90 M 2.43x43 Structure Structure
TM2 91 F 2.44x44 Structure Structure
TM2 92 N 2.45x45 Structure Structure
TM2 93 L 2.46x46 Structure Structure
TM2 94 A 2.47x47 Structure Structure
TM2 95 L 2.48x48 Structure Structure
TM2 96 A 2.49x49 Structure Structure
TM2 97 D 2.50x50 Structure Structure
TM2 98 F 2.51x51 Structure Structure
TM2 99 L 2.52x52 Structure Structure
TM2 100 Y 2.53x53 Structure Structure
TM2 101 V 2.54x54 Structure Structure
TM2 102 L 2.55x55 Structure Structure
TM2 103 T 2.56x56 Structure Structure
TM2 104 L 2.57x57 Structure Structure
TM2 105 P 2.58x58 Structure Structure
TM2 106 A 2.59x59 Structure Structure
TM2 107 L 2.60x60 Structure Structure
TM2 108 I 2.61x61 Structure Structure
TM2 109 F 2.62x62 Structure Structure
TM2 110 Y 2.63x63 Structure Structure
TM2 111 Y 2.64x64 Structure Structure
TM2 112 F 2.65x65 Structure Structure
TM2 113 N 2.66x66 Structure Structure
ECL1 114 K - Structure AF2
ECL1 115 T - Structure Structure
ECL1 116 D 23.49x49 Structure Structure
ECL1 117 W 23.50x50 Structure Structure
ECL1 118 I 23.51x51 Structure Structure
ECL1 119 F 23.52x52 Structure Structure
TM3 120 G 3.21x21 Structure Structure
TM3 121 D 3.22x22 Structure Structure
TM3 122 A 3.23x23 Structure Structure
TM3 123 M 3.24x24 Structure Structure
TM3 124 C 3.25x25 Structure Structure
TM3 125 K 3.26x26 Structure Structure
TM3 126 L 3.27x27 Structure Structure
TM3 127 Q 3.28x28 Structure Structure
TM3 128 R 3.29x29 Structure Structure
TM3 129 F 3.30x30 Structure Structure
TM3 130 I 3.31x31 Structure Structure
TM3 131 F 3.32x32 Structure Structure
TM3 132 H 3.33x33 Structure Structure
TM3 133 V 3.34x34 Structure Structure
TM3 134 N 3.35x35 Structure Structure
TM3 135 L 3.36x36 Structure Structure
TM3 136 Y 3.37x37 Structure Structure
TM3 137 G 3.38x38 Structure Structure
TM3 138 S 3.39x39 Structure Structure
TM3 139 I 3.40x40 Structure Structure
TM3 140 L 3.41x41 Structure Structure
TM3 141 F 3.42x42 Structure Structure
TM3 142 L 3.43x43 Structure Structure
TM3 143 T 3.44x44 Structure Structure
TM3 144 C 3.45x45 Structure Structure
TM3 145 I 3.46x46 Structure Structure
TM3 146 S 3.47x47 Structure Structure
TM3 147 A 3.48x48 Structure Structure
TM3 148 H 3.49x49 Structure Structure
TM3 149 R 3.50x50 Structure Structure
TM3 150 Y 3.51x51 Structure Structure
TM3 151 S 3.52x52 Structure Structure
TM3 152 G 3.53x53 Structure Structure
TM3 153 V 3.54x54 Structure Structure
TM3 154 V 3.55x55 Structure Structure
TM3 155 Y 3.56x56 Structure Structure
ICL2 156 P 34.50x50 Structure Structure
ICL2 157 L 34.51x51 Structure Structure
ICL2 158 K 34.52x52 Structure Structure
ICL2 159 S 34.53x53 Structure Structure
ICL2 160 L 34.54x54 Structure Structure
ICL2 161 G 34.55x55 Structure Structure
ICL2 162 R 34.56x56 Structure Structure
ICL2 163 L 34.57x57 Structure Structure
TM4 164 K 4.38x38 Structure Structure
TM4 165 K 4.39x39 Structure Structure
TM4 166 K 4.40x40 Structure AF2
TM4 167 N 4.41x41 Structure Structure
TM4 168 A 4.42x42 Structure Structure
TM4 169 I 4.43x43 Structure Structure
TM4 170 C 4.44x44 Structure Structure
TM4 171 I 4.45x45 Structure Structure
TM4 172 S 4.46x46 Structure Structure
TM4 173 V 4.47x47 Structure Structure
TM4 174 L 4.48x48 Structure Structure
TM4 175 V 4.49x49 Structure Structure
TM4 176 W 4.50x50 Structure Structure
TM4 177 L 4.51x51 Structure Structure
TM4 178 I 4.52x52 Structure Structure
TM4 179 V 4.53x53 Structure Structure
TM4 180 V 4.54x54 Structure Structure
TM4 181 V 4.55x55 Structure Structure
TM4 182 A 4.56x56 Structure Structure
TM4 183 I 4.57x57 Structure Structure
TM4 184 S 4.58x58 Structure Structure
TM4 185 P 4.59x59 Structure Structure
TM4 186 I 4.60x60 Structure Structure
TM4 187 L 4.61x61 Structure Structure
TM4 188 F 4.62x62 Structure Structure
TM4 189 Y 4.63x63 Structure Structure
TM4 190 S 4.64x64 Structure Structure
ECL2 191 G - Structure Structure
ECL2 192 T - Structure Structure
ECL2 193 G - Structure Structure
ECL2 194 V - Structure Structure
ECL2 195 R - Structure AF2
ECL2 196 K - Structure AF2
ECL2 197 N - Structure AF2
ECL2 198 K - Structure AF2
ECL2 199 T - Structure Structure
ECL2 200 I - Structure AF2
ECL2 201 T - Structure Structure
ECL2 202 C 45.50x50 Structure Structure
ECL2 203 Y 45.51x51 Structure Structure
ECL2 204 D 45.52x52 Structure AF2
ECL2 205 T - Structure Structure
ECL2 206 T - Structure Structure
ECL2 207 S - Structure Structure
ECL2 208 D - Structure AF2
ECL2 209 E - Structure AF2
ECL2 210 Y - Structure Structure
TM5 211 L 5.32x33 Structure Structure
TM5 212 R 5.33x34 Structure AF2
TM5 213 S 5.34x35 Structure Structure
TM5 214 Y 5.35x36 Structure Structure
TM5 215 F 5.36x37 Structure Structure
TM5 216 I 5.37x38 Structure Structure
TM5 217 Y 5.38x39 Structure Structure
TM5 218 S 5.39x40 Structure Structure
TM5 219 M 5.40x41 Structure Structure
TM5 220 C 5.41x42 Structure Structure
TM5 221 T 5.42x43 Structure Structure
TM5 222 T 5.43x44 Structure Structure
TM5 223 V 5.44x45 Structure Structure
TM5 224 A 5.45x46 Structure Structure
TM5 225 M 5.46x461 Structure Structure
TM5 226 F 5.47x47 Structure Structure
TM5 227 C 5.48x48 Structure Structure
TM5 228 V 5.49x49 Structure Structure
TM5 229 P 5.50x50 Structure Structure
TM5 230 L 5.51x51 Structure Structure
TM5 231 V 5.52x52 Structure Structure
TM5 232 L 5.53x53 Structure Structure
TM5 233 I 5.54x54 Structure Structure
TM5 234 L 5.55x55 Structure Structure
TM5 235 G 5.56x56 Structure Structure
TM5 236 C 5.57x57 Structure Structure
TM5 237 Y 5.58x58 Structure Structure
TM5 238 G 5.59x59 Structure Structure
TM5 239 L 5.60x60 Structure Structure
TM5 240 I 5.61x61 Structure Structure
TM5 241 V 5.62x62 Structure Structure
TM5 242 R 5.63x63 Structure Structure
TM5 243 A 5.64x64 Structure Structure
TM5 244 L 5.65x65 Structure Structure
TM5 245 I 5.66x66 Structure Structure
TM5 246 Y 5.67x67 Structure Structure
TM5 247 K 5.68x68 Structure Structure
ICL3 248 D - Structure Structure
ICL3 249 L - Structure Structure
ICL3 250 D - Structure Structure
ICL3 251 N - Structure Structure
ICL3 252 S - Structure Structure
TM6 253 P 6.28x29 Structure Structure
TM6 254 L 6.29x30 Structure Structure
TM6 255 R 6.30x31 Structure Structure
TM6 256 R 6.31x32 Structure Structure
TM6 257 K 6.32x33 Structure Structure
TM6 258 S 6.33x34 Structure Structure
TM6 259 I 6.34x35 Structure Structure
TM6 260 Y 6.35x36 Structure Structure
TM6 261 L 6.36x37 Structure Structure
TM6 262 V 6.37x38 Structure Structure
TM6 263 I 6.38x39 Structure Structure
TM6 264 I 6.39x40 Structure Structure
TM6 265 V 6.40x41 Structure Structure
TM6 266 L 6.41x42 Structure Structure
TM6 267 T 6.42x43 Structure Structure
TM6 268 V 6.43x44 Structure Structure
TM6 269 F 6.44x45 Structure Structure
TM6 270 A 6.45x46 Structure Structure
TM6 271 V 6.46x461 Structure Structure
TM6 272 S 6.47x47 Structure Structure
TM6 273 Y 6.48x48 Structure Structure
TM6 274 I 6.49x49 Structure Structure
TM6 275 P 6.50x50 Structure Structure
TM6 276 F 6.51x51 Structure Structure
TM6 277 H 6.52x52 Structure Structure
TM6 278 V 6.53x53 Structure Structure
TM6 279 M 6.54x54 Structure Structure
TM6 280 K 6.55x55 Structure AF2
TM6 281 T 6.56x56 Structure Structure
TM6 282 M 6.57x57 Structure Structure
TM6 283 N 6.58x58 Structure Structure
TM6 284 L 6.59x59 Structure Structure
TM6 285 R 6.60x60 Structure Structure
TM6 286 A 6.61x61 Structure Structure
TM6 287 R 6.62x62 Structure Structure
TM6 288 L 6.63x63 Structure Structure
TM6 289 D 6.64x64 Structure Structure
ECL3 290 F - Structure Structure
ECL3 291 Q - Structure Structure
ECL3 292 T - Structure Structure
ECL3 293 P - Structure Structure
ECL3 294 A - Structure Structure
TM7 295 M 7.24x23 Structure Structure
TM7 296 C 7.25x24 Structure Structure
TM7 297 A 7.26x25 Structure Structure
TM7 298 F 7.27x26 Structure Structure
TM7 299 N 7.28x27 Structure Structure
TM7 300 D 7.29x28 Structure Structure
TM7 301 R 7.30x29 Structure Structure
TM7 302 V 7.31x30 Structure Structure
TM7 303 Y 7.32x31 Structure Structure
TM7 304 A 7.33x32 Structure Structure
TM7 305 T 7.34x33 Structure Structure
TM7 306 Y 7.35x34 Structure Structure
TM7 307 Q 7.36x35 Structure Structure
TM7 308 V 7.37x36 Structure Structure
TM7 309 T 7.38x37 Structure Structure
TM7 310 R 7.39x38 Structure Structure
TM7 311 G 7.40x39 Structure Structure
TM7 312 L 7.41x40 Structure Structure
TM7 313 A 7.42x41 Structure Structure
TM7 314 S 7.43x42 Structure Structure
TM7 315 L 7.44x43 Structure Structure
TM7 316 N 7.45x45 Structure Structure
TM7 317 S 7.46x46 Structure Structure
TM7 318 C 7.47x47 Structure Structure
TM7 319 V 7.48x48 Structure Structure
TM7 320 D 7.49x49 Structure Structure
TM7 321 P 7.50x50 Structure Structure
TM7 322 I 7.51x51 Structure Structure
TM7 323 L 7.52x52 Structure Structure
TM7 324 Y 7.53x53 Structure Structure
TM7 325 F 7.54x54 Structure Structure
TM7 326 L 7.55x55 Structure Structure
TM7 327 A 7.56x56 Structure Structure
H8 328 G 8.47x47 Structure Structure
H8 329 D 8.48x48 Structure AF2
H8 330 T 8.49x49 Structure Structure
H8 331 F 8.50x50 Structure Structure
H8 332 R 8.51x51 Structure Structure
H8 333 R 8.52x52 Structure AF2
H8 334 R 8.53x53 Structure Structure
H8 335 L 8.54x54 Structure AF2
H8 336 S 8.55x55 Structure Structure
H8 337 R 8.56x56 Structure AF2
H8 338 A 8.57x57 Structure Structure
H8 339 T 8.58x58 Structure Structure
H8 340 R 8.59x59 Structure AF2
C-term 341 K - AF2 AF2
C-term 342 A - AF2 AF2
C-term 343 S - AF2 AF2
C-term 344 R - AF2 AF2
C-term 345 R - AF2 AF2
C-term 346 S - AF2 AF2
C-term 347 E - AF2 AF2
C-term 348 A - AF2 AF2
C-term 349 N - AF2 AF2
C-term 350 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 149 3x50 G.H5 Q 350 G.H5.17
Hydrophobic TM3 R 149 3x50 G.H5 Q 350 G.H5.17
Van-der-waals TM3 R 149 3x50 G.H5 Q 350 G.H5.17
Ionic ICL2 K 158 34x52 G.S2 E 191 G.S2.03
Polar H8 D 329 8x48 G.H5 N 352 G.H5.19
Hydrophobic H8 D 329 8x48 G.H5 N 352 G.H5.19
Van-der-waals H8 D 329 8x48 G.H5 N 352 G.H5.19
Polar H8 D 329 8x48 G.H5 K 354 G.H5.21
Hydrophobic H8 D 329 8x48 G.H5 K 354 G.H5.21
Van-der-waals H8 D 329 8x48 G.H5 K 354 G.H5.21
Hydrophobic H8 F 331 8x50 G.H5 L 351 G.H5.18
Van-der-waals H8 F 331 8x50 G.H5 L 351 G.H5.18
Hydrophobic ICL3 L 249 - G.H5 N 336 G.H5.03
Hydrophobic TM6 R 255 6x31 G.H5 V 344 G.H5.11
Van-der-waals TM6 R 255 6x31 G.H5 V 344 G.H5.11
Hydrophobic TM6 P 253 6x29 G.h4s6 N 317 G.h4s6.08
Hydrophobic ICL2 G 161 34x55 G.HN R 31 G.HN.49
Hydrophobic TM6 P 253 6x29 G.H5 L 358 G.H5.25
Van-der-waals TM6 P 253 6x29 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 156 34x50 G.H5 F 339 G.H5.06
Van-der-waals ICL2 P 156 34x50 G.H5 F 339 G.H5.06
Hydrophobic TM6 V 262 6x38 G.H5 Y 356 G.H5.23
Van-der-waals TM6 V 262 6x38 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 D 248 - G.H5 V 340 G.H5.07
Van-der-waals ICL3 D 248 - G.H5 V 340 G.H5.07
Hydrophobic TM7 A 327 7x56 G.H5 L 351 G.H5.18
Van-der-waals TM7 A 327 7x56 G.H5 L 351 G.H5.18
Hydrophobic TM3 Y 155 3x56 G.H5 F 339 G.H5.06
Hydrophobic TM6 P 253 6x29 G.H5 V 344 G.H5.11
Hydrophobic H8 G 328 8x47 G.H5 K 354 G.H5.21
Van-der-waals H8 G 328 8x47 G.H5 K 354 G.H5.21
Hydrophobic TM2 S 84 2x37 G.H5 L 349 G.H5.16
Van-der-waals TM2 S 84 2x37 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 156 34x50 G.H5 A 343 G.H5.10
Polar H8 D 329 8x48 G.H5 I 348 G.H5.15
Hydrophobic H8 D 329 8x48 G.H5 I 348 G.H5.15
Van-der-waals H8 D 329 8x48 G.H5 I 348 G.H5.15
Polar H8 T 330 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 T 330 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM6 R 255 6x31 G.H5 L 358 G.H5.25
Van-der-waals TM6 R 255 6x31 G.H5 L 358 G.H5.25
Hydrophobic ICL3 D 248 - G.H5 N 336 G.H5.03
Van-der-waals ICL3 D 248 - G.H5 N 336 G.H5.03
Hydrophobic TM6 L 261 6x37 G.H5 N 352 G.H5.19
Hydrophobic ICL3 L 249 - G.s6h5 D 333 G.s6h5.05
Hydrophobic TM6 L 254 6x30 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 254 6x30 G.H5 L 358 G.H5.25
Polar ICL2 G 161 34x55 G.HN Q 28 G.HN.46
Van-der-waals ICL2 G 161 34x55 G.HN Q 28 G.HN.46
Hydrophobic TM6 L 261 6x37 G.H5 Y 356 G.H5.23
Van-der-waals TM6 L 261 6x37 G.H5 Y 356 G.H5.23
Hydrophobic TM2 M 90 2x43 G.H5 L 351 G.H5.18
Van-der-waals TM2 M 90 2x43 G.H5 L 351 G.H5.18
Hydrophobic TM2 I 86 2x39 G.H5 Q 350 G.H5.17
Van-der-waals TM2 I 86 2x39 G.H5 Q 350 G.H5.17
Polar H8 D 329 8x48 G.H5 E 355 G.H5.22
Hydrophobic H8 D 329 8x48 G.H5 E 355 G.H5.22
Van-der-waals H8 D 329 8x48 G.H5 E 355 G.H5.22
Hydrophobic TM3 G 152 3x53 G.H5 D 346 G.H5.13
Van-der-waals TM3 G 152 3x53 G.H5 D 346 G.H5.13
Van-der-waals ICL2 L 160 34x54 G.HN D 32 G.HN.50
Hydrophobic H8 T 330 8x49 G.H5 L 351 G.H5.18
Van-der-waals H8 T 330 8x49 G.H5 L 351 G.H5.18
Hydrophobic TM3 V 154 3x55 G.H5 F 339 G.H5.06
Hydrophobic ICL3 S 252 - G.H5 V 340 G.H5.07
Van-der-waals ICL3 S 252 - G.H5 V 340 G.H5.07
Polar ICL3 N 251 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 N 251 - G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL2 L 157 34x51 G.H5 A 342 G.H5.09
Polar ICL2 G 161 34x55 G.HN D 32 G.HN.50
Hydrophobic ICL2 G 161 34x55 G.HN D 32 G.HN.50
Van-der-waals ICL2 G 161 34x55 G.HN D 32 G.HN.50
Hydrophobic ICL2 P 156 34x50 G.H5 A 342 G.H5.09
Polar H8 T 330 8x49 G.H5 I 348 G.H5.15
Van-der-waals H8 T 330 8x49 G.H5 I 348 G.H5.15
Hydrophobic TM2 I 86 2x39 G.H5 L 349 G.H5.16
Van-der-waals TM2 I 86 2x39 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 261 6x37 G.H5 E 355 G.H5.22
Van-der-waals TM6 L 261 6x37 G.H5 E 355 G.H5.22
Polar TM6 S 258 6x34 G.H5 Y 356 G.H5.23
Hydrophobic TM6 S 258 6x34 G.H5 Y 356 G.H5.23
Van-der-waals TM6 S 258 6x34 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 N 251 - G.h4s6 D 319 G.h4s6.10
Van-der-waals H8 D 329 8x48 G.H5 T 347 G.H5.14
Hydrophobic TM4 K 164 4x38 G.HN R 31 G.HN.49
Van-der-waals TM4 K 164 4x38 G.HN R 31 G.HN.49
Hydrophobic TM2 M 90 2x43 G.H5 Q 350 G.H5.17
Van-der-waals TM2 M 90 2x43 G.H5 Q 350 G.H5.17
Hydrophobic TM6 K 257 6x33 G.H5 N 357 G.H5.24
Hydrophobic TM4 K 164 4x38 G.HN Q 28 G.HN.46
Van-der-waals TM4 K 164 4x38 G.HN Q 28 G.HN.46
Van-der-waals ICL3 N 251 - G.h4s6 N 317 G.h4s6.08
Polar TM3 R 149 3x50 G.H5 N 352 G.H5.19
Hydrophobic TM3 R 149 3x50 G.H5 N 352 G.H5.19
Van-der-waals TM3 R 149 3x50 G.H5 N 352 G.H5.19
Polar H8 D 329 8x48 G.H5 L 351 G.H5.18
Hydrophobic H8 D 329 8x48 G.H5 L 351 G.H5.18
Van-der-waals H8 D 329 8x48 G.H5 L 351 G.H5.18
Hydrophobic TM6 K 257 6x33 G.H5 Y 356 G.H5.23
Van-der-waals TM6 K 257 6x33 G.H5 Y 356 G.H5.23
Polar TM7 A 327 7x56 G.H5 E 355 G.H5.22
Hydrophobic TM7 A 327 7x56 G.H5 E 355 G.H5.22
Van-der-waals TM7 A 327 7x56 G.H5 E 355 G.H5.22
Polar H8 D 329 8x48 G.H5 L 353 G.H5.20
Hydrophobic H8 D 329 8x48 G.H5 L 353 G.H5.20
Van-der-waals H8 D 329 8x48 G.H5 L 353 G.H5.20
Ionic TM6 K 257 6x33 G.H5 E 355 G.H5.22
Polar TM6 K 257 6x33 G.H5 E 355 G.H5.22
Hydrophobic TM6 K 257 6x33 G.H5 E 355 G.H5.22
Van-der-waals TM6 K 257 6x33 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 157 34x51 G.H5 F 339 G.H5.06
Van-der-waals ICL2 L 157 34x51 G.H5 F 339 G.H5.06
Polar TM3 H 148 3x49 G.H5 Q 350 G.H5.17
Hydrophobic TM3 H 148 3x49 G.H5 Q 350 G.H5.17
Van-der-waals TM3 H 148 3x49 G.H5 Q 350 G.H5.17
Polar ICL3 N 251 - G.h4s6 P 318 G.h4s6.09
Hydrophobic ICL3 N 251 - G.h4s6 P 318 G.h4s6.09
Hydrophobic ICL3 L 249 - G.H5 I 337 G.H5.04
Hydrophobic TM7 A 327 7x56 G.H5 K 354 G.H5.21