Refined structure (7Y26) of Gq - SST2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 214 from structure (59.6%), 145 from model (40.4%)
Residue sidechains - 94 from structure (26.2%), 265 from model (73.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 Structure AF2
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 AF2 AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure AF2
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure AF2
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure AF2
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 270 from structure (79.9%), 68 from model (20.1%)
Residue sidechains - 203 from structure (60.1%), 135 from model (39.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 M - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 E - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 H - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 W - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 I - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 V - AF2 AF2
N-term 26 V - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 T - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 Q - AF2 AF2
N-term 34 T - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 Y - AF2 AF2
N-term 38 Y - AF2 AF2
N-term 39 D - AF2 AF2
TM1 40 L 1.29x29 AF2 AF2
TM1 41 T 1.30x30 Structure Structure
TM1 42 S 1.31x31 Structure Structure
TM1 43 N 1.32x32 Structure Structure
TM1 44 A 1.33x33 Structure Structure
TM1 45 V 1.34x34 Structure AF2
TM1 46 L 1.35x35 Structure AF2
TM1 47 T 1.36x36 Structure Structure
TM1 48 F 1.37x37 Structure AF2
TM1 49 I 1.38x38 Structure AF2
TM1 50 Y 1.39x39 Structure Structure
TM1 51 F 1.40x40 Structure AF2
TM1 52 V 1.41x41 Structure AF2
TM1 53 V 1.42x42 Structure Structure
TM1 54 C 1.43x43 Structure Structure
TM1 55 I 1.44x44 Structure AF2
TM1 56 I 1.45x45 Structure AF2
TM1 57 G 1.46x46 Structure Structure
TM1 58 L 1.47x47 Structure Structure
TM1 59 C 1.48x48 Structure Structure
TM1 60 G 1.49x49 Structure Structure
TM1 61 N 1.50x50 Structure Structure
TM1 62 T 1.51x51 Structure AF2
TM1 63 L 1.52x52 Structure AF2
TM1 64 V 1.53x53 Structure Structure
TM1 65 I 1.54x54 Structure Structure
TM1 66 Y 1.55x55 Structure Structure
TM1 67 V 1.56x56 Structure Structure
TM1 68 I 1.57x57 Structure AF2
TM1 69 L 1.58x58 Structure AF2
TM1 70 R 1.59x59 Structure AF2
TM1 71 Y 1.60x60 Structure Structure
ICL1 72 A 12.48x48 Structure Structure
ICL1 73 K 12.49x49 Structure AF2
ICL1 74 M 12.50x50 Structure AF2
ICL1 75 K 12.51x51 Structure AF2
TM2 76 T 2.37x37 Structure Structure
TM2 77 I 2.38x38 Structure Structure
TM2 78 T 2.39x39 Structure Structure
TM2 79 N 2.40x40 Structure Structure
TM2 80 I 2.41x41 Structure Structure
TM2 81 Y 2.42x42 Structure Structure
TM2 82 I 2.43x43 Structure Structure
TM2 83 L 2.44x44 Structure Structure
TM2 84 N 2.45x45 Structure Structure
TM2 85 L 2.46x46 Structure Structure
TM2 86 A 2.47x47 Structure Structure
TM2 87 I 2.48x48 Structure Structure
TM2 88 A 2.49x49 Structure Structure
TM2 89 D 2.50x50 Structure AF2
TM2 90 E 2.51x51 Structure AF2
TM2 91 L 2.52x52 Structure Structure
TM2 92 F 2.53x53 Structure Structure
TM2 93 M 2.54x54 Structure Structure
TM2 94 L 2.55x55 Structure AF2
TM2 95 G 2.56x56 Structure Structure
TM2 96 L 2.57x57 Structure AF2
TM2 97 P 2.58x58 Structure Structure
TM2 98 F 2.59x59 Structure Structure
TM2 99 L 2.60x60 Structure AF2
TM2 100 A 2.61x61 Structure Structure
TM2 101 M 2.62x62 Structure AF2
TM2 102 Q 2.63x63 Structure AF2
TM2 103 V 2.64x64 Structure Structure
TM2 104 A 2.65x65 Structure Structure
TM2 105 L 2.66x66 Structure AF2
ECL1 106 V - Structure Structure
ECL1 107 H 23.49x49 Structure AF2
ECL1 108 W 23.50x50 Structure Structure
ECL1 109 P 23.51x51 Structure Structure
ECL1 110 F 23.52x52 Structure Structure
TM3 111 G 3.21x21 Structure Structure
TM3 112 K 3.22x22 Structure AF2
TM3 113 A 3.23x23 Structure Structure
TM3 114 I 3.24x24 Structure AF2
TM3 115 C 3.25x25 Structure Structure
TM3 116 R 3.26x26 Structure AF2
TM3 117 V 3.27x27 Structure Structure
TM3 118 V 3.28x28 Structure Structure
TM3 119 M 3.29x29 Structure Structure
TM3 120 T 3.30x30 Structure Structure
TM3 121 V 3.31x31 Structure Structure
TM3 122 D 3.32x32 Structure Structure
TM3 123 G 3.33x33 Structure Structure
TM3 124 I 3.34x34 Structure Structure
TM3 125 N 3.35x35 Structure Structure
TM3 126 Q 3.36x36 Structure Structure
TM3 127 F 3.37x37 Structure Structure
TM3 128 T 3.38x38 Structure Structure
TM3 129 S 3.39x39 Structure Structure
TM3 130 I 3.40x40 Structure Structure
TM3 131 F 3.41x41 Structure Structure
TM3 132 C 3.42x42 Structure Structure
TM3 133 L 3.43x43 Structure Structure
TM3 134 T 3.44x44 Structure Structure
TM3 135 V 3.45x45 Structure Structure
TM3 136 M 3.46x46 Structure Structure
TM3 137 S 3.47x47 Structure Structure
TM3 138 I 3.48x48 Structure Structure
TM3 139 D 3.49x49 Structure Structure
TM3 140 R 3.50x50 Structure Structure
TM3 141 Y 3.51x51 Structure Structure
TM3 142 L 3.52x52 Structure Structure
TM3 143 A 3.53x53 Structure Structure
TM3 144 V 3.54x54 Structure Structure
TM3 145 V 3.55x55 Structure Structure
TM3 146 H 3.56x56 Structure Structure
ICL2 147 P 34.50x50 Structure Structure
ICL2 148 I 34.51x51 Structure Structure
ICL2 149 K 34.52x52 Structure AF2
ICL2 150 S 34.53x53 Structure Structure
ICL2 151 A 34.54x54 Structure Structure
ICL2 152 K 34.55x55 Structure AF2
ICL2 153 W 34.56x56 Structure Structure
ICL2 154 R 34.57x57 Structure Structure
TM4 155 R 4.38x38 Structure AF2
TM4 156 P 4.39x39 Structure Structure
TM4 157 R 4.40x40 Structure AF2
TM4 158 T 4.41x41 Structure Structure
TM4 159 A 4.42x42 Structure Structure
TM4 160 K 4.43x43 Structure AF2
TM4 161 M 4.44x44 Structure Structure
TM4 162 I 4.45x45 Structure Structure
TM4 163 T 4.46x46 Structure Structure
TM4 164 M 4.47x47 Structure AF2
TM4 165 A 4.48x48 Structure Structure
TM4 166 V 4.49x49 Structure Structure
TM4 167 W 4.50x50 Structure Structure
TM4 168 G 4.51x51 Structure Structure
TM4 169 V 4.52x52 Structure Structure
TM4 170 S 4.53x53 Structure Structure
TM4 171 L 4.54x54 Structure Structure
TM4 172 L 4.55x55 Structure AF2
TM4 173 V 4.56x56 Structure Structure
TM4 174 I 4.57x57 Structure Structure
TM4 175 L 4.58x59 Structure AF2
TM4 176 P 4.59x60 Structure Structure
TM4 177 I 4.60x61 Structure Structure
TM4 178 M 4.61x62 Structure Structure
TM4 179 I 4.62x63 Structure Structure
TM4 180 Y 4.63x64 Structure AF2
TM4 181 A 4.64x65 Structure Structure
ECL2 182 G - Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 R - Structure AF2
ECL2 185 S - Structure Structure
ECL2 186 N - Structure AF2
ECL2 187 Q - Structure AF2
ECL2 188 W - Structure AF2
ECL2 189 G - Structure Structure
ECL2 190 R - Structure AF2
ECL2 191 S - Structure Structure
ECL2 192 S - Structure Structure
ECL2 193 C 45.50x50 Structure Structure
ECL2 194 T 45.51x51 Structure Structure
ECL2 195 I 45.52x52 Structure AF2
ECL2 196 N - Structure AF2
ECL2 197 W - Structure Structure
ECL2 198 P - AF2 AF2
ECL2 199 G - AF2 AF2
ECL2 200 E - AF2 AF2
TM5 201 S 5.31x32 AF2 AF2
TM5 202 G 5.32x33 Structure Structure
TM5 203 A 5.33x34 Structure Structure
TM5 204 W 5.34x35 Structure Structure
TM5 205 Y 5.35x36 Structure AF2
TM5 206 T 5.36x37 Structure AF2
TM5 207 G 5.37x38 Structure Structure
TM5 208 F 5.38x39 Structure Structure
TM5 209 I 5.39x40 Structure Structure
TM5 210 I 5.40x41 Structure AF2
TM5 211 Y 5.41x42 Structure Structure
TM5 212 T 5.42x43 Structure Structure
TM5 213 F 5.43x44 Structure Structure
TM5 214 I 5.44x45 Structure AF2
TM5 215 L 5.45x46 Structure Structure
TM5 216 G 5.46x461 Structure Structure
TM5 217 F 5.47x47 Structure Structure
TM5 218 L 5.48x48 Structure AF2
TM5 219 V 5.49x49 Structure Structure
TM5 220 P 5.50x50 Structure Structure
TM5 221 L 5.51x51 Structure Structure
TM5 222 T 5.52x52 Structure Structure
TM5 223 I 5.53x53 Structure Structure
TM5 224 I 5.54x54 Structure Structure
TM5 225 C 5.55x55 Structure Structure
TM5 226 L 5.56x56 Structure Structure
TM5 227 C 5.57x57 Structure Structure
TM5 228 Y 5.58x58 Structure Structure
TM5 229 L 5.59x59 Structure AF2
TM5 230 F 5.60x60 Structure Structure
TM5 231 I 5.61x61 Structure Structure
TM5 232 I 5.62x62 Structure Structure
TM5 233 I 5.63x63 Structure Structure
TM5 234 K 5.64x64 Structure Structure
TM5 235 V 5.65x65 Structure Structure
TM5 236 K 5.66x66 Structure AF2
TM5 237 S 5.67x67 Structure Structure
TM5 238 S 5.68x68 Structure Structure
ICL3 239 G - AF2 AF2
ICL3 240 I - AF2 AF2
ICL3 241 R - AF2 AF2
ICL3 242 V - AF2 AF2
ICL3 243 G - AF2 AF2
TM6 244 S 6.23x23 AF2 AF2
TM6 245 S 6.24x24 AF2 AF2
TM6 246 K 6.25x25 AF2 AF2
TM6 247 R 6.26x26 AF2 AF2
TM6 248 K 6.27x27 Structure Structure
TM6 249 K 6.28x28 Structure AF2
TM6 250 S 6.29x29 Structure Structure
TM6 251 E 6.30x30 Structure Structure
TM6 252 K 6.31x31 Structure AF2
TM6 253 K 6.32x32 Structure AF2
TM6 254 V 6.33x33 Structure Structure
TM6 255 T 6.34x34 Structure Structure
TM6 256 R 6.35x35 Structure AF2
TM6 257 M 6.36x36 Structure Structure
TM6 258 V 6.37x37 Structure Structure
TM6 259 S 6.38x38 Structure Structure
TM6 260 I 6.39x39 Structure Structure
TM6 261 V 6.40x40 Structure Structure
TM6 262 V 6.41x41 Structure Structure
TM6 263 A 6.42x42 Structure Structure
TM6 264 V 6.43x43 Structure Structure
TM6 265 F 6.44x44 Structure Structure
TM6 266 I 6.45x45 Structure Structure
TM6 267 F 6.46x46 Structure AF2
TM6 268 C 6.47x47 Structure Structure
TM6 269 W 6.48x48 Structure Structure
TM6 270 L 6.49x49 Structure Structure
TM6 271 P 6.50x50 Structure Structure
TM6 272 F 6.51x51 Structure Structure
TM6 273 Y 6.52x52 Structure Structure
TM6 274 I 6.53x53 Structure Structure
TM6 275 F 6.54x54 Structure AF2
TM6 276 N 6.55x55 Structure Structure
TM6 277 V 6.56x56 Structure AF2
TM6 278 S 6.57x57 Structure Structure
TM6 279 S 6.58x58 Structure Structure
TM6 280 V 6.59x59 Structure Structure
TM6 281 S 6.60x60 Structure Structure
TM6 282 M 6.61x61 Structure Structure
ECL3 283 A - AF2 AF2
ECL3 284 I - AF2 AF2
ECL3 285 S - AF2 AF2
ECL3 286 P - Structure Structure
TM7 287 T 7.28x27 Structure Structure
TM7 288 P 7.29x28 Structure Structure
TM7 289 A 7.30x29 Structure Structure
TM7 290 L 7.31x30 Structure AF2
TM7 291 K 7.32x31 Structure AF2
TM7 292 G 7.33x32 Structure Structure
TM7 293 M 7.34x33 Structure AF2
TM7 294 F 7.35x34 Structure Structure
TM7 295 D 7.36x35 Structure AF2
TM7 296 F 7.37x36 Structure Structure
TM7 297 V 7.38x37 Structure Structure
TM7 298 V 7.39x38 Structure Structure
TM7 299 V 7.40x39 Structure Structure
TM7 300 L 7.41x40 Structure Structure
TM7 301 T 7.42x41 Structure Structure
TM7 302 Y 7.43x42 Structure Structure
TM7 303 A 7.44x43 Structure Structure
TM7 304 N 7.45x45 Structure Structure
TM7 305 S 7.46x46 Structure Structure
TM7 306 C 7.47x47 Structure Structure
TM7 307 A 7.48x48 Structure Structure
TM7 308 N 7.49x49 Structure Structure
TM7 309 P 7.50x50 Structure Structure
TM7 310 I 7.51x51 Structure Structure
TM7 311 L 7.52x52 Structure Structure
TM7 312 Y 7.53x53 Structure Structure
TM7 313 A 7.54x54 Structure Structure
TM7 314 F 7.55x55 Structure Structure
TM7 315 L 7.56x56 Structure Structure
H8 316 S 8.47x47 Structure Structure
H8 317 D 8.48x48 Structure AF2
H8 318 N 8.49x49 Structure Structure
H8 319 F 8.50x50 Structure Structure
H8 320 K 8.51x51 Structure Structure
H8 321 K 8.52x52 Structure AF2
H8 322 S 8.53x53 Structure Structure
H8 323 F 8.54x54 Structure AF2
H8 324 Q 8.55x55 Structure AF2
H8 325 N 8.56x56 Structure AF2
H8 326 V 8.57x57 Structure Structure
H8 327 L 8.58x58 AF2 AF2
H8 328 C 8.59x59 AF2 AF2
C-term 329 L - AF2 AF2
C-term 330 V - AF2 AF2
C-term 331 K - AF2 AF2
C-term 332 V - AF2 AF2
C-term 333 S - AF2 AF2
C-term 334 G - AF2 AF2
C-term 335 T - AF2 AF2
C-term 336 D - AF2 AF2
C-term 337 D - AF2 AF2
C-term 338 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 148 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 I 148 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 V 144 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 235 5x65 G.H5 L 353 G.H5.20
Polar ICL2 R 154 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM5 I 231 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 144 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 147 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 K 345 G.H5.12
Polar H8 N 318 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 N 318 8x49 G.H5 E 355 G.H5.22
Polar ICL2 K 152 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 K 152 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM3 A 143 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 143 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 I 148 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 I 148 34x51 G.H5 F 341 G.H5.08
Van-der-waals TM2 T 76 2x37 G.H5 E 355 G.H5.22