Refined structure (7Y67) of Gi1 - C5a1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 224 from structure (63.3%), 130 from model (36.7%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 AF2 AF2
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 276 from structure (87.9%), 38 from model (12.1%)
Residue sidechains - 275 from structure (87.6%), 39 from model (12.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 Y - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 Y - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 H - AF2 AF2
N-term 14 Y - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 D - AF2 AF2
N-term 17 K - AF2 AF2
N-term 18 D - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 D - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 N - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 V - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 K - AF2 AF2
N-term 29 T - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 N - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 L - AF2 AF2
TM1 34 R 1.29x29 Structure Structure
TM1 35 V 1.30x30 Structure Structure
TM1 36 P 1.31x31 Structure Structure
TM1 37 D 1.32x32 Structure Structure
TM1 38 I 1.33x33 Structure Structure
TM1 39 L 1.34x34 Structure Structure
TM1 40 A 1.35x35 Structure Structure
TM1 41 L 1.36x36 Structure Structure
TM1 42 V 1.37x37 Structure Structure
TM1 43 I 1.38x38 Structure Structure
TM1 44 F 1.39x39 Structure Structure
TM1 45 A 1.40x40 Structure Structure
TM1 46 V 1.41x41 Structure Structure
TM1 47 V 1.42x42 Structure Structure
TM1 48 F 1.43x43 Structure Structure
TM1 49 L 1.44x44 Structure Structure
TM1 50 V 1.45x45 Structure Structure
TM1 51 G 1.46x46 Structure Structure
TM1 52 V 1.47x47 Structure Structure
TM1 53 L 1.48x48 Structure Structure
TM1 54 G 1.49x49 Structure Structure
TM1 55 N 1.50x50 Structure Structure
TM1 56 A 1.51x51 Structure Structure
TM1 57 L 1.52x52 Structure Structure
TM1 58 V 1.53x53 Structure Structure
TM1 59 V 1.54x54 Structure Structure
TM1 60 W 1.55x55 Structure Structure
TM1 61 V 1.56x56 Structure Structure
TM1 62 T 1.57x57 Structure Structure
TM1 63 A 1.58x58 Structure Structure
TM1 64 F 1.59x59 Structure Structure
TM1 65 E 1.60x60 Structure Structure
ICL1 66 A - Structure Structure
ICL1 67 K - Structure Structure
ICL1 68 R - Structure Structure
TM2 69 T 2.37x37 Structure Structure
TM2 70 I 2.38x38 Structure Structure
TM2 71 N 2.39x39 Structure Structure
TM2 72 A 2.40x40 Structure Structure
TM2 73 I 2.41x41 Structure Structure
TM2 74 W 2.42x42 Structure Structure
TM2 75 F 2.43x43 Structure Structure
TM2 76 L 2.44x44 Structure Structure
TM2 77 N 2.45x45 Structure Structure
TM2 78 L 2.46x46 Structure Structure
TM2 79 A 2.47x47 Structure Structure
TM2 80 V 2.48x48 Structure Structure
TM2 81 A 2.49x49 Structure Structure
TM2 82 D 2.50x50 Structure Structure
TM2 83 F 2.51x51 Structure Structure
TM2 84 L 2.52x52 Structure Structure
TM2 85 S 2.53x53 Structure Structure
TM2 86 C 2.54x54 Structure Structure
TM2 87 L 2.55x55 Structure Structure
TM2 88 A 2.56x56 Structure Structure
TM2 89 L 2.57x57 Structure Structure
TM2 90 P 2.58x58 Structure Structure
TM2 91 I 2.59x59 Structure Structure
TM2 92 L 2.60x60 Structure Structure
TM2 93 F 2.61x61 Structure Structure
TM2 94 T 2.62x62 Structure Structure
TM2 95 S 2.63x63 Structure Structure
TM2 96 I 2.64x64 Structure Structure
TM2 97 V 2.65x65 Structure Structure
TM2 98 Q 2.66x66 Structure Structure
TM2 99 H 2.67x67 Structure Structure
ECL1 100 H - Structure Structure
ECL1 101 H 23.49x49 Structure Structure
ECL1 102 W 23.50x50 Structure Structure
ECL1 103 P 23.51x51 Structure Structure
ECL1 104 F 23.52x52 Structure Structure
TM3 105 G 3.21x21 Structure Structure
TM3 106 G 3.22x22 Structure Structure
TM3 107 A 3.23x23 Structure Structure
TM3 108 A 3.24x24 Structure Structure
TM3 109 C 3.25x25 Structure Structure
TM3 110 S 3.26x26 Structure Structure
TM3 111 I 3.27x27 Structure Structure
TM3 112 L 3.28x28 Structure Structure
TM3 113 P 3.29x29 Structure Structure
TM3 114 S 3.30x30 Structure Structure
TM3 115 L 3.31x31 Structure Structure
TM3 116 I 3.32x32 Structure AF2
TM3 117 L 3.33x33 Structure Structure
TM3 118 L 3.34x34 Structure Structure
TM3 119 N 3.35x35 Structure Structure
TM3 120 M 3.36x36 Structure Structure
TM3 121 Y 3.37x37 Structure Structure
TM3 122 A 3.38x38 Structure Structure
TM3 123 S 3.39x39 Structure Structure
TM3 124 I 3.40x40 Structure Structure
TM3 125 L 3.41x41 Structure Structure
TM3 126 L 3.42x42 Structure Structure
TM3 127 L 3.43x43 Structure Structure
TM3 128 A 3.44x44 Structure Structure
TM3 129 T 3.45x45 Structure Structure
TM3 130 I 3.46x46 Structure Structure
TM3 131 S 3.47x47 Structure Structure
TM3 132 A 3.48x48 Structure Structure
TM3 133 D 3.49x49 Structure Structure
TM3 134 R 3.50x50 Structure Structure
TM3 135 F 3.51x51 Structure Structure
TM3 136 L 3.52x52 Structure Structure
TM3 137 L 3.53x53 Structure Structure
TM3 138 V 3.54x54 Structure Structure
TM3 139 F 3.55x55 Structure Structure
TM3 140 K 3.56x56 Structure Structure
ICL2 141 P 34.50x50 Structure Structure
ICL2 142 I 34.51x51 Structure Structure
ICL2 143 W 34.52x52 Structure Structure
ICL2 144 C 34.53x53 Structure Structure
ICL2 145 Q 34.54x54 Structure Structure
ICL2 146 N 34.55x55 Structure Structure
ICL2 147 F 34.56x56 Structure Structure
ICL2 148 R 34.57x57 Structure Structure
TM4 149 G 4.38x38 Structure Structure
TM4 150 A 4.39x39 Structure Structure
TM4 151 G 4.40x40 Structure Structure
TM4 152 L 4.41x41 Structure Structure
TM4 153 A 4.42x42 Structure Structure
TM4 154 W 4.43x43 Structure Structure
TM4 155 I 4.44x44 Structure Structure
TM4 156 A 4.45x45 Structure Structure
TM4 157 C 4.46x46 Structure Structure
TM4 158 A 4.47x47 Structure Structure
TM4 159 V 4.48x48 Structure Structure
TM4 160 A 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 G 4.51x51 Structure Structure
TM4 163 L 4.52x52 Structure Structure
TM4 164 A 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 L 4.55x55 Structure Structure
TM4 167 L 4.56x56 Structure Structure
TM4 168 T 4.57x57 Structure Structure
TM4 169 I 4.58x59 Structure Structure
TM4 170 P 4.59x60 Structure Structure
TM4 171 S 4.60x61 Structure Structure
TM4 172 F 4.61x62 Structure Structure
TM4 173 L 4.62x63 Structure Structure
TM4 174 Y 4.63x64 Structure Structure
TM4 175 R 4.64x65 Structure Structure
ECL2 176 V - Structure Structure
ECL2 177 V - Structure Structure
ECL2 178 R - Structure Structure
ECL2 179 E - Structure Structure
ECL2 180 E - Structure Structure
ECL2 181 Y - AF2 AF2
ECL2 182 F - AF2 AF2
ECL2 183 P - AF2 AF2
ECL2 184 P - AF2 AF2
ECL2 185 K - AF2 AF2
ECL2 186 V - Structure Structure
ECL2 187 L - Structure Structure
ECL2 188 C 45.50x50 Structure Structure
ECL2 189 G 45.51x51 Structure Structure
ECL2 190 V 45.52x52 Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 Y - Structure Structure
ECL2 193 S - Structure Structure
ECL2 194 H - Structure Structure
TM5 195 D 5.31x32 Structure Structure
TM5 196 K 5.32x33 Structure Structure
TM5 197 R 5.33x34 Structure Structure
TM5 198 R 5.34x35 Structure Structure
TM5 199 E 5.35x36 Structure Structure
TM5 200 R 5.36x37 Structure Structure
TM5 201 A 5.37x38 Structure Structure
TM5 202 V 5.38x39 Structure Structure
TM5 203 A 5.39x40 Structure Structure
TM5 204 I 5.40x41 Structure Structure
TM5 205 V 5.41x42 Structure Structure
TM5 206 R 5.42x43 Structure Structure
TM5 207 L 5.43x44 Structure Structure
TM5 208 V 5.44x45 Structure Structure
TM5 209 L 5.45x46 Structure Structure
TM5 210 G 5.46x461 Structure Structure
TM5 211 F 5.47x47 Structure Structure
TM5 212 L 5.48x48 Structure Structure
TM5 213 W 5.49x49 Structure Structure
TM5 214 P 5.50x50 Structure Structure
TM5 215 L 5.51x51 Structure Structure
TM5 216 L 5.52x52 Structure Structure
TM5 217 T 5.53x53 Structure Structure
TM5 218 L 5.54x54 Structure Structure
TM5 219 T 5.55x55 Structure Structure
TM5 220 I 5.56x56 Structure Structure
TM5 221 C 5.57x57 Structure Structure
TM5 222 Y 5.58x58 Structure Structure
TM5 223 T 5.59x59 Structure Structure
TM5 224 F 5.60x60 Structure Structure
TM5 225 I 5.61x61 Structure Structure
TM5 226 L 5.62x62 Structure Structure
TM5 227 L 5.63x63 Structure Structure
TM5 228 R 5.64x64 Structure Structure
TM5 229 T 5.65x65 Structure Structure
TM5 230 W 5.66x66 Structure Structure
TM5 231 S 5.67x67 Structure Structure
TM5 232 R 5.68x68 Structure Structure
ICL3 233 R - Structure Structure
ICL3 234 A - Structure Structure
ICL3 235 T - Structure Structure
ICL3 236 R - Structure Structure
ICL3 237 S - Structure Structure
TM6 238 T 6.31x31 Structure Structure
TM6 239 K 6.32x32 Structure Structure
TM6 240 T 6.33x33 Structure Structure
TM6 241 L 6.34x34 Structure Structure
TM6 242 K 6.35x35 Structure Structure
TM6 243 V 6.36x36 Structure Structure
TM6 244 V 6.37x37 Structure Structure
TM6 245 V 6.38x38 Structure Structure
TM6 246 A 6.39x39 Structure Structure
TM6 247 V 6.40x40 Structure Structure
TM6 248 V 6.41x41 Structure Structure
TM6 249 A 6.42x42 Structure Structure
TM6 250 S 6.43x43 Structure Structure
TM6 251 F 6.44x44 Structure Structure
TM6 252 F 6.45x45 Structure Structure
TM6 253 I 6.46x46 Structure Structure
TM6 254 F 6.47x47 Structure Structure
TM6 255 W 6.48x48 Structure Structure
TM6 256 L 6.49x49 Structure Structure
TM6 257 P 6.50x50 Structure Structure
TM6 258 Y 6.51x51 Structure Structure
TM6 259 Q 6.52x52 Structure Structure
TM6 260 V 6.53x53 Structure Structure
TM6 261 T 6.54x54 Structure Structure
TM6 262 G 6.55x55 Structure Structure
TM6 263 I 6.56x56 Structure Structure
TM6 264 M 6.57x57 Structure Structure
TM6 265 M 6.58x58 Structure Structure
TM6 266 S 6.59x59 Structure Structure
TM6 267 F 6.60x60 Structure Structure
TM6 268 L 6.61x61 Structure Structure
ECL3 269 E - Structure Structure
ECL3 270 P - Structure Structure
ECL3 271 S - Structure Structure
TM7 272 S 7.25x24 Structure Structure
TM7 273 P 7.26x25 Structure Structure
TM7 274 T 7.27x26 Structure Structure
TM7 275 F 7.28x27 Structure Structure
TM7 276 L 7.29x28 Structure Structure
TM7 277 L 7.30x29 Structure Structure
TM7 278 L 7.31x30 Structure Structure
TM7 279 K 7.32x31 Structure Structure
TM7 280 K 7.33x32 Structure Structure
TM7 281 L 7.34x33 Structure Structure
TM7 282 D 7.35x34 Structure Structure
TM7 283 S 7.36x35 Structure Structure
TM7 284 L 7.37x36 Structure Structure
TM7 285 C 7.38x37 Structure Structure
TM7 286 V 7.39x38 Structure Structure
TM7 287 S 7.40x39 Structure Structure
TM7 288 F 7.41x40 Structure Structure
TM7 289 A 7.42x41 Structure Structure
TM7 290 Y 7.43x42 Structure Structure
TM7 291 I 7.44x43 Structure Structure
TM7 292 N 7.45x45 Structure Structure
TM7 293 C 7.46x46 Structure Structure
TM7 294 C 7.47x47 Structure Structure
TM7 295 I 7.48x48 Structure Structure
TM7 296 N 7.49x49 Structure Structure
TM7 297 P 7.50x50 Structure Structure
TM7 298 I 7.51x51 Structure Structure
TM7 299 I 7.52x52 Structure Structure
TM7 300 Y 7.53x53 Structure Structure
TM7 301 V 7.54x54 Structure Structure
TM7 302 V 7.55x55 Structure Structure
TM7 303 A 7.56x56 Structure Structure
TM7 304 G 7.57x57 Structure Structure
C-term 305 Q - Structure Structure
C-term 306 G - Structure Structure
C-term 307 F - Structure Structure
C-term 308 Q - Structure Structure
C-term 309 G - Structure Structure
C-term 310 R - Structure Structure
C-term 311 L - Structure Structure
C-term 312 R - Structure Structure
C-term 313 K - Structure Structure
C-term 314 S - Structure Structure



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 235 - G.H5 K 345 G.H5.17
Polar TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 137 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 232 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 232 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 232 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 232 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 141 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 239 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 138 3x54 G.H5 L 348 G.H5.20
Polar ICL3 S 237 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 S 237 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 S 237 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 T 235 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 T 235 - G.H5 I 344 G.H5.16
Hydrophobic TM3 V 138 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 138 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 T 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 T 235 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 145 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 225 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 236 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 142 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 243 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 229 5x65 G.H5 L 348 G.H5.20
Polar TM6 K 239 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 239 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM2 N 71 2x39 G.H5 C 351 G.H5.23
Polar TM2 N 71 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 244 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Polar ICL2 R 148 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 148 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 142 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 I 142 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 N 146 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 146 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 I 142 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03