Refined structure (8XYD) of Gi1 - PAF receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2025-03-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (92.3%), 25 from model (7.7%)
Residue sidechains - 298 from structure (92.3%), 25 from model (7.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 H - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 H - AF2 AF2
N-term 9 M - AF2 AF2
TM1 10 D 1.27x27 AF2 AF2
TM1 11 S 1.28x28 AF2 AF2
TM1 12 E 1.29x29 Structure Structure
TM1 13 F 1.30x30 Structure Structure
TM1 14 R 1.31x31 Structure Structure
TM1 15 Y 1.32x32 Structure Structure
TM1 16 T 1.33x33 Structure Structure
TM1 17 L 1.34x34 Structure Structure
TM1 18 F 1.35x35 Structure Structure
TM1 19 P 1.36x36 Structure Structure
TM1 20 I 1.37x37 Structure Structure
TM1 21 V 1.38x38 Structure Structure
TM1 22 Y 1.39x39 Structure Structure
TM1 23 S 1.40x40 Structure Structure
TM1 24 I 1.41x41 Structure Structure
TM1 25 I 1.42x42 Structure Structure
TM1 26 F 1.43x43 Structure Structure
TM1 27 V 1.44x44 Structure Structure
TM1 28 L 1.45x45 Structure Structure
TM1 29 G 1.46x46 Structure Structure
TM1 30 V 1.47x47 Structure Structure
TM1 31 I 1.48x48 Structure Structure
TM1 32 A 1.49x49 Structure Structure
TM1 33 N 1.50x50 Structure Structure
TM1 34 G 1.51x51 Structure Structure
TM1 35 Y 1.52x52 Structure Structure
TM1 36 V 1.53x53 Structure Structure
TM1 37 L 1.54x54 Structure Structure
TM1 38 W 1.55x55 Structure Structure
TM1 39 V 1.56x56 Structure Structure
TM1 40 F 1.57x57 Structure Structure
TM1 41 A 1.58x58 Structure Structure
TM1 42 R 1.59x59 Structure Structure
TM1 43 L 1.60x60 Structure Structure
TM1 44 Y 1.61x61 Structure Structure
ICL1 45 P - Structure Structure
ICL1 46 C - Structure Structure
ICL1 47 K - Structure Structure
ICL1 48 K - Structure Structure
TM2 49 F 2.36x36 Structure Structure
TM2 50 N 2.37x37 Structure Structure
TM2 51 E 2.38x38 Structure Structure
TM2 52 I 2.39x39 Structure Structure
TM2 53 K 2.40x40 Structure Structure
TM2 54 I 2.41x41 Structure Structure
TM2 55 F 2.42x42 Structure Structure
TM2 56 M 2.43x43 Structure Structure
TM2 57 V 2.44x44 Structure Structure
TM2 58 N 2.45x45 Structure Structure
TM2 59 L 2.46x46 Structure Structure
TM2 60 T 2.47x47 Structure Structure
TM2 61 M 2.48x48 Structure Structure
TM2 62 A 2.49x49 Structure Structure
TM2 63 D 2.50x50 Structure Structure
TM2 64 M 2.51x51 Structure Structure
TM2 65 L 2.52x52 Structure Structure
TM2 66 F 2.53x53 Structure Structure
TM2 67 L 2.54x54 Structure Structure
TM2 68 I 2.55x55 Structure Structure
TM2 69 T 2.56x56 Structure Structure
TM2 70 L 2.57x57 Structure Structure
TM2 71 P 2.58x58 Structure Structure
TM2 72 L 2.59x59 Structure Structure
TM2 73 W 2.60x60 Structure Structure
TM2 74 I 2.61x61 Structure Structure
TM2 75 V 2.62x62 Structure Structure
TM2 76 Y 2.63x63 Structure Structure
TM2 77 Y 2.64x64 Structure Structure
TM2 78 Q 2.65x65 Structure Structure
TM2 79 N 2.66x66 Structure Structure
TM2 80 Q 2.67x67 Structure Structure
ECL1 81 G - Structure Structure
ECL1 82 N 23.49x49 Structure Structure
ECL1 83 W 23.50x50 Structure Structure
ECL1 84 I 23.51x51 Structure Structure
ECL1 85 L 23.52x52 Structure Structure
TM3 86 P 3.21x21 Structure Structure
TM3 87 K 3.22x22 Structure Structure
TM3 88 F 3.23x23 Structure Structure
TM3 89 L 3.24x24 Structure Structure
TM3 90 C 3.25x25 Structure Structure
TM3 91 N 3.26x26 Structure Structure
TM3 92 V 3.27x27 Structure Structure
TM3 93 A 3.28x28 Structure Structure
TM3 94 G 3.29x29 Structure Structure
TM3 95 C 3.30x30 Structure Structure
TM3 96 L 3.31x31 Structure Structure
TM3 97 F 3.32x32 Structure Structure
TM3 98 F 3.33x33 Structure Structure
TM3 99 I 3.34x34 Structure Structure
TM3 100 N 3.35x35 Structure Structure
TM3 101 T 3.36x36 Structure Structure
TM3 102 Y 3.37x37 Structure Structure
TM3 103 C 3.38x38 Structure Structure
TM3 104 S 3.39x39 Structure Structure
TM3 105 V 3.40x40 Structure Structure
TM3 106 A 3.41x41 Structure Structure
TM3 107 F 3.42x42 Structure Structure
TM3 108 L 3.43x43 Structure Structure
TM3 109 G 3.44x44 Structure Structure
TM3 110 V 3.45x45 Structure Structure
TM3 111 I 3.46x46 Structure Structure
TM3 112 T 3.47x47 Structure Structure
TM3 113 Y 3.48x48 Structure Structure
TM3 114 N 3.49x49 Structure Structure
TM3 115 R 3.50x50 Structure Structure
TM3 116 F 3.51x51 Structure Structure
TM3 117 Q 3.52x52 Structure Structure
TM3 118 A 3.53x53 Structure Structure
TM3 119 V 3.54x54 Structure Structure
TM3 120 T 3.55x55 Structure Structure
TM3 121 R 3.56x56 Structure Structure
ICL2 122 P 34.50x50 Structure Structure
ICL2 123 I 34.51x51 Structure Structure
ICL2 124 K 34.52x52 Structure Structure
ICL2 125 T 34.53x53 Structure Structure
ICL2 126 A 34.54x54 Structure Structure
ICL2 127 Q 34.55x55 Structure Structure
ICL2 128 A 34.56x56 Structure Structure
ICL2 129 N 34.57x57 Structure Structure
TM4 130 T 4.38x38 Structure Structure
TM4 131 R 4.39x39 Structure Structure
TM4 132 K 4.40x40 Structure Structure
TM4 133 R 4.41x41 Structure Structure
TM4 134 G 4.42x42 Structure Structure
TM4 135 I 4.43x43 Structure Structure
TM4 136 S 4.44x44 Structure Structure
TM4 137 L 4.45x45 Structure Structure
TM4 138 S 4.46x46 Structure Structure
TM4 139 L 4.47x47 Structure Structure
TM4 140 V 4.48x48 Structure Structure
TM4 141 I 4.49x49 Structure Structure
TM4 142 W 4.50x50 Structure Structure
TM4 143 V 4.51x51 Structure Structure
TM4 144 A 4.52x52 Structure Structure
TM4 145 I 4.53x53 Structure Structure
TM4 146 V 4.54x54 Structure Structure
TM4 147 G 4.55x55 Structure Structure
TM4 148 A 4.56x56 Structure Structure
TM4 149 A 4.57x57 Structure Structure
TM4 150 S 4.58x58 Structure Structure
TM4 151 Y 4.59x59 Structure Structure
TM4 152 F 4.60x60 Structure Structure
TM4 153 L 4.61x61 Structure Structure
TM4 154 I 4.62x62 Structure Structure
TM4 155 L 4.63x63 Structure Structure
ECL2 156 D - Structure Structure
ECL2 157 S - Structure Structure
ECL2 158 T - Structure Structure
ECL2 159 N - Structure Structure
ECL2 160 T - Structure Structure
ECL2 161 V - Structure Structure
ECL2 162 P - Structure Structure
ECL2 163 D - Structure Structure
ECL2 164 S - Structure Structure
ECL2 165 A - Structure Structure
ECL2 166 G - Structure Structure
ECL2 167 S - Structure Structure
ECL2 168 G - Structure Structure
ECL2 169 N - Structure Structure
ECL2 170 V - Structure Structure
ECL2 171 T - Structure Structure
ECL2 172 R - Structure Structure
ECL2 173 C 45.50x50 Structure Structure
ECL2 174 F 45.51x51 Structure Structure
ECL2 175 E 45.52x52 Structure Structure
ECL2 176 H - Structure Structure
ECL2 177 Y - Structure Structure
ECL2 178 E - Structure Structure
ECL2 179 K - Structure Structure
ECL2 180 G - Structure Structure
TM5 181 S 5.33x33 Structure Structure
TM5 182 V 5.34x34 Structure Structure
TM5 183 P 5.35x35 Structure Structure
TM5 184 V 5.36x36 Structure Structure
TM5 185 L 5.37x37 Structure Structure
TM5 186 I 5.38x38 Structure Structure
TM5 187 I 5.39x39 Structure Structure
TM5 188 H 5.40x40 Structure Structure
TM5 189 I 5.41x41 Structure Structure
TM5 190 F 5.42x42 Structure Structure
TM5 191 I 5.43x43 Structure Structure
TM5 192 V 5.44x44 Structure Structure
TM5 193 F 5.45x45 Structure Structure
TM5 194 S 5.46x46 Structure Structure
TM5 195 F 5.47x47 Structure Structure
TM5 196 F 5.48x48 Structure Structure
TM5 197 L 5.49x49 Structure Structure
TM5 198 V 5.50x50 Structure Structure
TM5 199 F 5.51x51 Structure Structure
TM5 200 L 5.52x52 Structure Structure
TM5 201 I 5.53x53 Structure Structure
TM5 202 I 5.54x54 Structure Structure
TM5 203 L 5.55x55 Structure Structure
TM5 204 F 5.56x56 Structure Structure
TM5 205 C 5.57x57 Structure Structure
TM5 206 N 5.58x58 Structure Structure
TM5 207 L 5.59x59 Structure Structure
TM5 208 V 5.60x60 Structure Structure
TM5 209 I 5.61x61 Structure Structure
TM5 210 I 5.62x62 Structure Structure
TM5 211 R 5.63x63 Structure Structure
TM5 212 T 5.64x64 Structure Structure
TM5 213 L 5.65x65 Structure Structure
TM5 214 L 5.66x66 Structure Structure
TM5 215 M 5.67x67 Structure Structure
TM5 216 Q 5.68x68 Structure Structure
ICL3 217 P - Structure Structure
ICL3 218 V - Structure Structure
ICL3 219 Q - Structure Structure
ICL3 220 Q - Structure Structure
TM6 221 Q 6.24x25 Structure Structure
TM6 222 R 6.25x26 Structure Structure
TM6 223 N 6.26x27 Structure Structure
TM6 224 A 6.27x28 Structure Structure
TM6 225 E 6.28x29 Structure Structure
TM6 226 V 6.29x30 Structure Structure
TM6 227 K 6.30x31 Structure Structure
TM6 228 R 6.31x32 Structure Structure
TM6 229 R 6.32x33 Structure Structure
TM6 230 A 6.33x34 Structure Structure
TM6 231 L 6.34x35 Structure Structure
TM6 232 W 6.35x36 Structure Structure
TM6 233 M 6.36x37 Structure Structure
TM6 234 V 6.37x38 Structure Structure
TM6 235 C 6.38x39 Structure Structure
TM6 236 T 6.39x40 Structure Structure
TM6 237 V 6.40x41 Structure Structure
TM6 238 L 6.41x42 Structure Structure
TM6 239 A 6.42x43 Structure Structure
TM6 240 V 6.43x44 Structure Structure
TM6 241 F 6.44x45 Structure Structure
TM6 242 I 6.45x46 Structure Structure
TM6 243 I 6.46x461 Structure Structure
TM6 244 C 6.47x47 Structure Structure
TM6 245 F 6.48x48 Structure Structure
TM6 246 V 6.49x49 Structure Structure
TM6 247 P 6.50x50 Structure Structure
TM6 248 H 6.51x51 Structure Structure
TM6 249 H 6.52x52 Structure Structure
TM6 250 V 6.53x53 Structure Structure
TM6 251 V 6.54x54 Structure Structure
TM6 252 Q 6.55x55 Structure Structure
TM6 253 L 6.56x56 Structure Structure
TM6 254 P 6.57x57 Structure Structure
TM6 255 W 6.58x58 Structure Structure
TM6 256 T 6.59x59 Structure Structure
TM6 257 L 6.60x60 Structure Structure
TM6 258 A 6.61x61 Structure Structure
TM6 259 E 6.62x62 Structure Structure
TM6 260 L 6.63x63 Structure Structure
TM6 261 G 6.64x64 Structure Structure
ECL3 262 F - Structure Structure
ECL3 263 Q - Structure Structure
TM7 264 D 7.24x23 Structure Structure
TM7 265 S 7.25x24 Structure Structure
TM7 266 K 7.26x25 Structure Structure
TM7 267 F 7.27x26 Structure Structure
TM7 268 H 7.28x27 Structure Structure
TM7 269 Q 7.29x28 Structure Structure
TM7 270 A 7.30x29 Structure Structure
TM7 271 I 7.31x30 Structure Structure
TM7 272 N 7.32x31 Structure Structure
TM7 273 D 7.33x32 Structure Structure
TM7 274 A 7.34x33 Structure Structure
TM7 275 H 7.35x34 Structure Structure
TM7 276 Q 7.36x35 Structure Structure
TM7 277 V 7.37x36 Structure Structure
TM7 278 T 7.38x37 Structure Structure
TM7 279 L 7.39x38 Structure Structure
TM7 280 C 7.40x39 Structure Structure
TM7 281 L 7.41x40 Structure Structure
TM7 282 L 7.42x41 Structure Structure
TM7 283 S 7.43x42 Structure Structure
TM7 284 T 7.44x43 Structure Structure
TM7 285 N 7.45x45 Structure Structure
TM7 286 C 7.46x46 Structure Structure
TM7 287 V 7.47x47 Structure Structure
TM7 288 L 7.48x48 Structure Structure
TM7 289 D 7.49x49 Structure Structure
TM7 290 P 7.50x50 Structure Structure
TM7 291 V 7.51x51 Structure Structure
TM7 292 I 7.52x52 Structure Structure
TM7 293 Y 7.53x53 Structure Structure
TM7 294 C 7.54x54 Structure Structure
TM7 295 F 7.55x55 Structure Structure
TM7 296 L 7.56x56 Structure Structure
TM7 297 T 7.57x57 Structure Structure
TM7 298 K 7.58x58 Structure Structure
TM7 299 K 7.59x59 Structure Structure
H8 300 F 8.50x50 Structure Structure
H8 301 R 8.51x51 Structure Structure
H8 302 K 8.52x52 Structure Structure
H8 303 H 8.53x53 Structure Structure
H8 304 L 8.54x54 Structure Structure
H8 305 T 8.55x55 Structure Structure
H8 306 E 8.56x56 Structure Structure
H8 307 K 8.57x57 Structure Structure
H8 308 F 8.58x58 Structure Structure
H8 309 Y 8.59x59 Structure Structure
H8 310 S 8.60x60 AF2 AF2
H8 311 M 8.61x61 AF2 AF2
H8 312 R 8.62x62 AF2 AF2
H8 313 S 8.63x63 AF2 AF2
C-term 314 S - AF2 AF2
C-term 315 R - AF2 AF2
C-term 316 K - AF2 AF2
C-term 317 C - AF2 AF2
C-term 318 S - AF2 AF2
C-term 319 R - AF2 AF2
C-term 320 A - AF2 AF2
C-term 321 T - AF2 AF2
C-term 322 T - AF2 AF2
C-term 323 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 N 223 6x27 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 122 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 I 123 34x51 G.H5 T 340 G.H5.12
Ionic TM6 R 222 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 222 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 222 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 222 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 123 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 115 3x50 G.H5 L 353 G.H5.25
Polar ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 226 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 126 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 127 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 127 34x55 G.S3 L 194 G.S3.01
Polar TM6 R 222 6x26 G.S6 I 319 G.S6.01
Hydrophobic TM6 R 222 6x26 G.S6 I 319 G.S6.01
Van-der-waals TM6 R 222 6x26 G.S6 I 319 G.S6.01
Hydrophobic TM6 M 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM7 T 297 7x57 G.H5 F 354 G.H5.26
Van-der-waals TM7 T 297 7x57 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 226 6x30 G.H5 L 348 G.H5.20
Polar TM7 T 297 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 297 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 297 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 119 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 126 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM2 I 52 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 234 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 229 6x33 G.H5 F 354 G.H5.26
Polar ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 A 118 3x53 G.H5 N 347 G.H5.19
Polar TM6 N 223 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 230 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 230 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 118 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 118 3x53 G.H5 C 351 G.H5.23
Polar TM7 K 298 7x58 G.H5 K 349 G.H5.21
Hydrophobic TM7 K 298 7x58 G.H5 K 349 G.H5.21
Van-der-waals TM7 K 298 7x58 G.H5 K 349 G.H5.21
Hydrophobic ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Aromatic H8 R 301 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 301 8x51 G.H5 F 354 G.H5.26
Polar TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 226 6x30 G.H5 F 354 G.H5.26
Polar TM6 R 222 6x26 G.S6 Y 320 G.S6.02
Aromatic TM6 R 222 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 222 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 222 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 233 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 233 6x37 G.H5 F 354 G.H5.26
Polar ICL2 T 125 34x53 G.H5 N 347 G.H5.19